Title: Portabale toothbrush dispenser

Applicant/Assignee:

Application No.: 12/150788   Filing Date: 19/Jun/2008

Abstract:I claim that my Portable Toothbrush Dispenser will contain both toothbrush and clear through dispenser. The toothbrush section will contain 3 small holes for use of disbursement of equal toothpaste or gel. The Dispenser will have a mechanism lever which will help with the dispensing of product. Portable Toothbrush Dispenser will have colorful caps and will be sized in a portable way. It will fit in shirt pockets or pants just like carrying a pen. The material to make this product can be recycled plastic being that its good for the environment.

Priority:

Inventor: VEGA-CORTES BEATRIZ [US]

Title: Container lid having multiple utilities

Applicant/Assignee:

Application No.: 12/456540   Filing Date: 19/Jun/2009

Abstract:The prevention from hardening upon storage of paste-like material by use of a lid having an inlet port, an outlet port, and a plastic bag attached to the inlet port. By expelling the air in contact with the paste-like material, the material can be prevented from hardening during storage. A similar lid is used in a pre-cleaning device situated between a dust-producing tool and a wet/dry vacuum. Dust-laden air enters the device through an inlet port and is discharged over a water filter. The pre-cleaned air is vacuumed to a wet/dry vacuum. The pre-cleaning process lengthens the useful life of the wet/dry vacuum. A hand-held sander is disclosed which provides for rapid change of sandpaper. The sander has a hollow upper handle component and a lower surface component which are held together with a latch. Depressing of a quick-release button allows separation of the two parts.

Priority: US20080999779P Applic. Date: 2008-07-01

Inventor: YARBROUGH GLEN A [US]

Title: DISMANTLEABLE VEHICLE SEAT

Applicant/Assignee: INNOVATION & SAFETY, S.L

Application No.: 12/305147   Filing Date: 09/Mar/2007

Abstract:Detachable vehicle seat, with a back structure and a seat structure

coupling means for coupling the seat structure to the back structure

securing means for securing the seat structure to a part of the vehicle floor

a rapid detachment mechanism that permits the seat to be decoupled from the back

at least one first strap is coupled to the structure of the back part of the seat in a zone corresponding to the abdominal zone of the person

a headrest in which at least one second strap is coupled in a zone corresponding to the zone of the head of the person.

Priority: EP20060380174 Applic. Date: 2006-06-16; WO2007ES00131 Applic. Date: 2007-03-09

Inventor: DE RICO HERRERO SERGIO [ES]

Title: Silicone composition

Applicant/Assignee: MOMENTIVE PERFORMANCE MATERIALS, INC

Application No.: 12/217548   Filing Date: 07/Jul/2008

Abstract:This invention relates to silicone-containing compositions, method of making said silicone-containing compositions, and to personal care and other products based on such compositions.

Priority:

Inventor: WAHL ROY UWE [US]

Title: Antimicrobial Composition

Applicant/Assignee:

Application No.: 12/304204   Filing Date: 13/Jun/2007

Abstract:Use of a composition comprising hyaluronic acid or a pharmaceutically acceptable salt thereof, in the manufacture of a topical medicament for antimicrobial treatment of the skin or mucosa.

Priority: IT2006MI01132 Applic. Date: 2006-06-13; WO2007GB02197 Applic. Date: 2007-06-13

Inventor: MASTRODONATO MARCO [IT]

Title: Dental File with Improved Tip Configuration

Applicant/Assignee:

Application No.: 12/167905   Filing Date: 03/Jul/2008

Abstract:A dental instrument for cleaning and shaping a root canal of a tooth includes a working portion having three helical flutes and a guide tip with a first, second, and third face surface. A portion of the guide tip is removed so that each of the first and second surfaces are contiguous to a lateral surface of a conical-shaped envelope defining the original tip but a portion of the third surface is not contiguous to a lateral surface of the conical-shaped envelope. The intersection of the first and second surfaces, however, remains at the center point of the guide tip. The removed portion of the guide tip may result in an arcuate-shaped face surface, an angular-shaped face surface, or some combination of the two.

Priority:

Inventor: JOHNSON WILLIAM B [US]

Title: Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same

Applicant/Assignee: RENOVIS, INC

Application No.: 12/224357   Filing Date: 22/Feb/2007

Abstract:Compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Priority: US20060776106P Applic. Date: 2006-02-23; US20060775949P Applic. Date: 2006-02-23; US20060776058P Applic. Date: 2006-02-23; US20060776057P Applic. Date: 2006-02-23; US20060775930P Applic. Date: 2006-02-23; US20060776033P Applic. Date: 2006-02-23; US20060775945P Applic. Date: 2006-02-23; US20060776056P Applic. Date: 2006-02-23; US20060776105P Applic. Date: 2006-02-23; US20060839903P Applic. Date: 2006-08-24; US20060839994P Applic. Date: 2006-08-24; US20060776064P Applic. Date: 2006-02-23; WO2007US04912 Applic. Date: 2007-02-22

Inventor: KELLY MICHAEL G [US]; KAUB CARL J [US]; KINCAID JOHN [US]; JANAGANI SATYANARAYANA [US]; WU GUOXIAN [US]; WEI ZHI-LIANG [US]; SAHASRABUDHE KIRAN [US]; DUNCTON MATTHEW [US]; UPASANI RAVINDRA B [US]; FANG YUNFENG [US]; COX MATTHEW [US]; HE JIANHUA [US]

Title: HETEROCYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS

Applicant/Assignee: VERTEX PHARMACEUTICALS INCORPORATED

Application No.: 12/495880   Filing Date: 01/Jul/2009

Abstract:The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Priority: US20080077220P Applic. Date: 2008-07-01

Inventor: ZIMMERMANN NICOLE [US]; GROOTENHUIS PETER D J [US]; NUMA MEHDI MICHEL DJAMEL [US]; STAMOS DEAN [US]; ANDERSON COREY DON [US]; WHITNEY TARA [US]

Title: Oral Care Implement

Applicant/Assignee: COLGATE-PALMOLIVE COMPANY

Application No.: 12/560894   Filing Date: 16/Sep/2009

Abstract:An oral care implement with a soft tissue cleanser is provided to effectively cleanse the soft tissue of the mouth with comfort and a reduced risk of injury to the user. In one construction, a projection is formed of a combination of a hard material and a soft material. The hard material provides good stability for cleaning debris from the tongue or other tissue while the soft material provides comfort and a reduced risk of injury.

Priority: US2005-261048 Applic. Date: 2005-10-28; US2004-011605 Applic. Date: 2004-12-15; US2004-019671 Applic. Date: 2004-12-23; US2004-869922 Applic. Date: 2004-06-18; US2003-601106 Applic. Date: 2003-06-20; WO2003US30633 Applic. Date: 2003-09-26; WO2003US29497 Applic. Date: 2003-09-17; US20030189729F Applic. Date: 2003-09-10; US2004-989267 Applic. Date: 2004-11-17; US20040209242F Applic. Date: 2004-07-14; US20020414117P Applic. Date: 2002-09-27; US20020418776P Applic. Date: 2002-10-16; US20020419425P Applic. Date: 2002-10-18; US20020412290P Applic. Date: 2002-09-20

Inventor: MOSKOVICH ROBERT [US]

Title: Plasma cleaning method

Applicant/Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURG

Application No.: 11/794796   Filing Date: 25/Jan/2006

Abstract:The present invention relates to an improved method for cleaning using plasma In particular, the present invention relates to the plasma cleaning and decontamination of instruments for use in medicine, dentistry and food preparation whereby the soiled item is exposed to a solvent and then to a plasma, whereby this enables excitation of water within the soil itself.

Priority: GB20050001460 Applic. Date: 2005-01-25; WO2006GB00247 Applic. Date: 2006-01-25

Inventor: BAXTER ROBERT [GB]; BAXTER HELEN [GB]

Title: APPARATUS FOR CRACKING THE MOLECULAR STRUCTURE OF LONG CHAIN ORGANIC SUBSTANCES

Applicant/Assignee: ENERCUT S.R.L

Application No.: 12/375442   Filing Date: 13/Aug/2007

Abstract:An apparatus for cracking organic substances, for making a mixture of solid and/or liquid and/or gaseous components. The device comprises a cracking chamber (5) with substantially tubular walls arranged between an inlet port (beta) of said organic substances and an outlet port (7) of the mixture. In the chamber (5) a rotor shaft is arranged (23) associated with rotary actuating means (24) of the rotor shaft (23) with respect to the walls of the chamber in such a way that the cracking occurs by friction of the substances during the relative rotation between the rotor shaft (23) and the walls of the cracking chamber (5). A feeding device pushes the substances in the cracking chamber (5), where they are subject to a high speed mixing action owing to the rotor shaft (23), and a variable gap (S) adjusts the friction, in particular, in a first tubular section (20) of the chamber (5), so that the transformation temperature reaches a desired value. Then the products pass through the gap (S), from the first tubular section (20) to a second tubular section (21), which may have diameter larger than the first and where the transformation is completed, and then are transferred to a degassing device through the outlet port (7).

Priority: IT2006BO00603 Applic. Date: 2006-08-11; WO2007IB02335 Applic. Date: 2007-08-13

Inventor: PECCI GIORGIO [IT]

Title: CIS-CYCLOHEXYL SUBSTITUTED PYRIMIDINONE DERIVATIVES

Applicant/Assignee: NEUROGEN CORPORATION

Application No.: 12/436587   Filing Date: 06/May/2009

Abstract:Cis-cyclohexyl substituted pyrimidinone derivatives are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

Priority: WO2007US23318 Applic. Date: 2007-11-05; US20060864460P Applic. Date: 2006-11-06

Inventor: BLUM CHARLES A [US]; GHOSH MANUKA [US]; MARTINEZ ISAMIR [US]; ZHANG XUECHUN [US]; ZHENG XIAOZHANG [US]

Title: Rapid-Melt Compositions and Methods of Making Same

Applicant/Assignee: CAPRICORN PHARMA, INC

Application No.: 12/501652   Filing Date: 13/Jul/2009

Abstract:The present invention provides a novel rapid-melt pharmaceutical composition comprising a binder, a super emulsifier, a diluent/bulking material

and an active ingredient. The present invention also provides a rapid-melt bead composition comprising a binder having a melting point from about 20 to about 90 DEG C., an emulsifier

a diluent/bulking material

and an active ingredient. Further, the present invention provides a chew tablet composition comprising a binder

an emulsifier having a melting point of greater than about 40 DEG C.

a diluent/bulking material

and an active ingredient. Methods of making the disclosed compositions are also described.

Priority: US2007-818212 Applic. Date: 2007-06-12; US2002-208877 Applic. Date: 2002-08-01; US2001-898471 Applic. Date: 2001-07-05; US2001-858885 Applic. Date: 2001-05-17; US2000-610489 Applic. Date: 2000-07-05

Inventor: CHERUKURI S RAO [US]

Title: Double dual shoe to pant hem protector clip clamp

Applicant/Assignee:

Application No.: 12/456919   Filing Date: 24/Jun/2009

Abstract:Double dual shoe to hem protective clip clamp prevents a baggy pant hem from dragging on the ground by attaching one clamp to the pant hem, with the other clamp attaching directly onto the shoe heel rim. The device is made of two components, an upper clamp and a lower clamp, which may be attached permanently, or may be interchanged for versatility.

Priority: US2008-148359 Applic. Date: 2008-04-13; US20070925891P Applic. Date: 2007-04-23; US20070925892P Applic. Date: 2007-04-23; US20070925889P Applic. Date: 2007-04-23; US20070925866P Applic. Date: 2007-04-23; US20070925887P Applic. Date: 2007-04-23; US20070925890P Applic. Date: 2007-04-23

Inventor: ALI CECELIA ELAINE [US]; BROMELL LORENZO ALEXIS [US]

Title: Water refilling assembly for hydro pack

Applicant/Assignee:

Application No.: 12/219184   Filing Date: 17/Jul/2008

Abstract:A hydro pack includes a water bag with a handle on a top end thereof and a outlet frame is located on a lower end of the water bag. A connection member is connected with the outlet frame and a hose with semi-circular cross section is connected to the connection member. The other end of the hose is connected with a female unit. A universal mouth piece assembly, a bottle water connector, a faucet connector, a filtering unit and a suction unit each have a male part which is optionally connected with the female unit so as to conveniently and quick refill clean water in the water bag.

Priority:

Inventor: LIEN CHIEN-PING [TW]

Title: Bottle Closure with Two Interlocking Parts One Fitting Over the Other

Applicant/Assignee: ZORK PTY LTD

Application No.: 12/377786   Filing Date: 17/Aug/2007

Abstract:The present invention describes a bottle closure for bottles containing liquids at high pressure, such as bottles of sparkling wine, the closure having a first part and a second part, the first part having a portion adapted to receive a portion of an upper section of a neck of the bottle, and a second part that fits substantially over the first part, which is relatively movable with respect to the first part and has at least two positions, a first of which is in a free position and a second of which is in an interlocking position whereby a portion of the second part urges against a portion of the first part receiving the upper section of the neck of the bottle so as to be engaging against an outer side of the said first part to hold it thereby to resist release from its interlocking position with respect to the said neck of an industry standard bottle.

Priority: AU20060904443 Applic. Date: 2006-08-17; WO2007AU01161 Applic. Date: 2007-08-17

Inventor: BROOKS JOHN [AU]

Title: INTERNAL CONTAINER BORE MOUNT FITMENT

Applicant/Assignee: PORTOLA PACKAGING, INC

Application No.: 12/520459   Filing Date: 21/Dec/2007

Abstract:In an embodiment of the invention there is provided a membrane fitment designed and sized to be inserted into the orifice defined by a container. Retention structure on the fitment cooperates with complimentary structure on the internal wall of the container orifice to secure the fitment within the orifice such that the combination forms an excellent primary seal. Tamper evidence is offered by the normal requirement for initial membrane removal. Novel designs for the membrane, its associated pull ring, and the frangible removal structure are taught in various embodiments. The novel designs may promote facile initial removal suitable for a child. In addition, the novel designs avoid the potential hazards presented by prior art membranes.

Priority: US20060871723P Applic. Date: 2006-12-22; WO2007US88538 Applic. Date: 2007-12-21

Inventor: LOHRMAN RICHARD [US]; HENNESSY THOMAS [US]; KIM SUNGSUK STEVE [US]

Title: Tooth Whitening Compositions and Methods

Applicant/Assignee: BASF CATALYSTS LLC

Application No.: 12/502907   Filing Date: 14/Jul/2009

Abstract:A non-cytotoxic chlorine dioxide composition and a mixed agent bleaching composition for tooth whitening are disclosed. Methods of use are also provided.

Priority: US20080135011P Applic. Date: 2008-07-15; US20080106026P Applic. Date: 2008-10-16; US20090150685P Applic. Date: 2009-02-06

Inventor: SPERONELLO BARRY KEVEN [US]; CASTELLANA FRANK S [US]; HRATKO LINDA [US]

Title: Board game system for teaching and promoting proper hygiene

Applicant/Assignee:

Application No.: 12/218336   Filing Date: 15/Jul/2008

Abstract:This invention relates to an educational device employing a board game system to teach basic hygiene concepts, routines and processes to both children and developmentally challenged individuals. The educational board game consists of a playing field with a plurality of spaces that define a path of travel and specific hygiene tasks which require simulation by the players. Movement about the game board is facilitated by a random selection from a numerical value and special instruction deck of playing cards. Each time a player can correctly identify the steps necessary to complete a hygiene task properly and in correct order they receive an "Artifact" card. The first player to collect all six "Artifact" cards by completing all six of the hygiene task simulations and is the first to reach the center of the playing board wins the game.

Priority:

Inventor: WULF PAUL ARTHUR [US]; WULF DEBRA ANN [US]

Title: HIGH EFFICIENCY GAS LIGHTING DEVICE FOR AN ELECTRIC HOUSEHOLD APPLIANCE, IN PARTICULAR A COOKING RANGE

Applicant/Assignee:

Application No.: 12/529326   Filing Date: 25/Mar/2008

Abstract:A gas lighting device including: a body formed by an electrically insulating material carrying a plurality of high-voltage outputs for the connection of spark generating means

a transformer accommodated in the body and including a primary winding wound around and carried by a ferromagnetic material core, a carrying element formed by an electrically insulating material and designed to contain the primary winding therein, and a secondary winding consisting of a plurality of coils externally carried by the carrying element, electrically insulated from the primary winding and essentially coaxial with the latter

the core is ring-shaped on a plane parallel to an axis (A) of the windings and consists of two half rings reciprocally coupled and arranged facing and closely adjacent to each other in the direction of the axis of the windings

a first circumferential portion of the ring-shaped core, formed by one or both of the half rings, is accommodated inside the carrying element so as to be surrounded by the windings, while a second circumferential portion of the core is formed parallel to the first and radially on the outside of the windings so as not to be surrounded by the same.

Priority: IT2007TO00217 Applic. Date: 2007-03-26; WO2008IB00696 Applic. Date: 2008-03-25

Inventor: PIANEZZE DANIELE [IT]; ALEARDI MASSIMO [IT]

Title: Methods and Compositions For Altering Biological Surfaces

Applicant/Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Application No.: 12/309049   Filing Date: 06/Jul/2007

Abstract:Compositions, methods and kits are provided for altering the properties of a biological surface using particles such as, for instance, calcium based particles in combination with an agent that binds to the biological surface. Properties such as color, sheen, texture, strength, and odor of biological surfaces such as teeth and bone are alterable.

Priority: US20060818509P Applic. Date: 2006-07-06; WO2007US15525 Applic. Date: 2007-07-06

Inventor: KARP JEFFREY M [US]; KHADEMHOSSEINI ALIREZA [US]; BERRY DAVID A [US]; LANGER ROBERT S [US]; GU FRANK X [US]

Title: Designer Ubiquitin Ligases For Regulation Of Intracellular Pathogenic Proteins

Applicant/Assignee:

Application No.: 12/482420   Filing Date: 10/Jun/2009

Abstract:The present invention relates to a designer or recombinant ubiquitin ligase molecule that includes a toxin binding domain that is specific for a toxin active fragment, wherein the toxin active fragment is an enzymatically active fragment of one or more toxins or toxin serotypes

and an E3-ligase domain that comprises an E3-ligase or polypeptide that facilitates E2-mediated ubiquitination of the toxin active fragment. In an embodiment, the composition further includes a delivery system that allow the designer ubiquitin ligase to enter the cell. The present invention further includes methods for treating an individual intoxicated with a toxin by administering the designer ubiquitin ligase of the present invention.

Priority: US20080060324P Applic. Date: 2008-06-10

Inventor: OYLER GEORGE A [US]; TSAI YIEN CHE [US]

Title: MACRO-SIZED LIPID CAPSULE EMULSION COMPOSITION AND COSMETIC COMPOSITION CONTAINING THE SAME

Applicant/Assignee: AMOREPACIFIC CORPORATION

Application No.: 12/300251   Filing Date: 30/Nov/2006

Abstract:An emulsion composition of the invention has macro-sized (0.01 to 5 mm) lipid capsule particles and it is for a skin cosmetic composition. An emulsion composition of the invention exhibits improved stability for its particle size by adjusting a size of the particle through a combination of liquid phase oil and integument lipid or lipoid material and encapsulating the liquid phase oil with the integument lipid. The emulsion composition of the invention has unique outward appearance and use feeling due to the macro-sized particles in it, also exhibits excellent skin safety and moisture persistence by containing no surfactant and maintains an activity of an oleophilic effective ingredient which is apt to be oxidized for a long time.

Priority: KR20060042420 Applic. Date: 2006-05-11; WO2006KR05111 Applic. Date: 2006-11-30

Inventor: KANG CHAN KOO [KR]; KANG HAK HEE [KR]; PARK CHANG HOON [KR]; HAN SANG HOON [KR]

Title: Methods for Treating Oral Cavity Infections with Chlorine Dioxide

Applicant/Assignee: BASF CATALYSTS LLC

Application No.: 12/502913   Filing Date: 14/Jul/2009

Abstract:Methods, devices, compositions, and systems for the alleviation of oral tissue infections by administration of chlorine dioxide are provided.

Priority: US20080135011P Applic. Date: 2008-07-15; US20080106026P Applic. Date: 2008-10-16; US20090150685P Applic. Date: 2009-02-06; US20090187198P Applic. Date: 2009-06-15

Inventor: SPERONELLO BARRY KEVEN [US]; CASTELLANA FRANK S [US]

Title: Combination of Copper Cations with Peroxides or Quaternary Ammonium Compounds for the Treatment of Biofilms

Applicant/Assignee:

Application No.: 12/428747   Filing Date: 23/Apr/2009

Abstract:The present invention relates to a method of inhibiting biofilms by combinations of antimicrobials, particularly with their synergistic activity against bioFilms. The antimicrobials include combination of copper ion and quaternary ammonium compound or combination of copper ion and peroxide. The invention also include methods for inhibiting biofilm-induced microbial corrosion or fouling.

Priority: US20080047634P Applic. Date: 2008-04-24

Inventor: HARRISON JOE [CA]; TURNER RAYMOND [CA]; CERI HOWARD [CA]

Title: Shower head attachment for mixing liquids used to clean teeth

Applicant/Assignee:

Application No.: 12/586441   Filing Date: 22/Sep/2009

Abstract:A valve for adjusting the flow of water through an oral irrigation device is connected to a shower head by a flexible conduit. The valve is located on a handle connected to a water-dispensing pick for cleaning teeth and gums. Mixing apparatus is provided for injecting a secondary fluid, such as a mouthwash, into the flexible conduit upstream from the pick in a direct stream from the shower head.

Priority: US2007-900763 Applic. Date: 2007-10-15

Inventor: SHAW DANIEL A [US]

Title: Aesthetic ceramic veneered restoration

Applicant/Assignee:

Application No.: 12/384290   Filing Date: 02/Apr/2009

Abstract:The present invention relates to an aesthetic dental restoration having a layered structure, which dental restoration has the appearance of a natural tooth. In addition, the present invention relates to a method for preparing such dental restorations. Particularly, the invention is based on the control of interaction between opalescence and fluorescence.

Priority: EP20020078949 Applic. Date: 2002-09-20; US2006-544681 Applic. Date: 2006-10-06; US2003-668552 Applic. Date: 2003-09-22

Inventor: VAN DER ZEL JOSEPH MARIA [NL]; APPLEMAN PETRUS GERARDUS [NL]; CORNELISSEN ERIC MARINUS HERMANUS [NL]; DE KLER MARCEL ANDRE [NL]; GEBHARDT JURGEN [DE]

Title: METHOD AND APPARATUS FOR DIAGNOSTIC AND TREATMENT USING HARD TISSUE OR MATERIAL MICROPERFORATION

Applicant/Assignee: REJUVEDENT LLC

Application No.: 12/503990   Filing Date: 16/Jul/2009

Abstract:A method of modifying or treating biological tissue by microperforating hard tissue is disclosed. The method comprises identifying a target area associated with the hard tissue, using a laser beam to perforate at least one incision in the hard tissue, wherein at least one incision has a diameter from a range of 0.001 mm to 0.5 mm and an aspect ratio from a range of 1 to 100 times, introducing a treatment substance into the incision, and causing the treatment substance to interact with the target area. Also a device for microperforating hard biological tissue is disclosed, comprising a laser pump system and a laser head coupled to the laser pump system for generating a pulsed laser having ranges of wavelengths, a pulse duration, pulse energy from a selected range, a beam divergence factor less than 5, a repetition rate higher than 50 Hz

and a beam delivery system comprised of a focusing system for creating a beam having a diameter from a range of 0.001 mm to 0.5 mm.

Priority: WO2008US51241 Applic. Date: 2008-01-16; US20070885009P Applic. Date: 2007-01-16

Inventor: ALTSHULER GREGORY B [US]; BELIKOV ANDREY V [RU]; FELDCHTEIN FELIX I [US]; TUCHIN VALERY V [RU]; VYBORNOV ALEXANDER G [US]

Title: METHODS OF USING A DENTAL COMPOSITION HAVING AN ACIDIC COMPONENT AND A PHOTOBLEACHABLE DYE

Applicant/Assignee:

Application No.: 12/517739   Filing Date: 12/Dec/2007

Abstract:Methods of using a dental composition having a photobleachable dye and an acidic component with a pKa of less than 4.5 are disclosed. The photobleachable dye is selected from the group consisting of aminoanthraquinone dyes, azo dyes, and combinations thereof. The aged color of the dental composition is substantially the same as the color of the dental composition immediately after hardening.

Priority: US20060869741P Applic. Date: 2006-12-13; WO2007US87192 Applic. Date: 2007-12-12

Inventor: FALSAFI AFSHIN [US]; OXMAN JOEL D [US]; TON TIFFANY T [US]; BRENNAN JOAN V [US]; CINADER JR DAVID K [US]; VELAMAKANNI BHASKAR V [US]; MITRA SUMITA B [US]

Title: Granulated crystal compilation composed of pure organic minerals used in all food applications resulting in energy supplementation, diet and weight regulation, and medicinal effects

Applicant/Assignee:

Application No.: 12/153790   Filing Date: 19/Jul/2008

Abstract:A composition made of pure natural minerals that can be used in all food applications resulting in energy supplementation, diet and weight regulation, and medicinal benefits.

Priority:

Inventor: HASSANI DANIEL [US]

Title: Long-Lasting Gustatory and/or Olfactory Aversion Veterinary Compositions for Behavior Modification

Applicant/Assignee:

Application No.: 12/499899   Filing Date: 09/Jul/2009

Abstract:Disclosed herein are gustatory and/or olfactory aversion compositions comprising one or more bitterants and appropriate adhesives or tackifiers, and the like, which provide a long-lasting effect. The compositions are useful for behavior modification, especially in animals, such as pets or livestock.

Priority: US20080081531P Applic. Date: 2008-07-17

Inventor: CLEMENT RICHARD J [US]; CLEMENT-FRAZIER KATI [US]

Title: DENTAL COMPOSITIONS WITH NATURAL TOOTH FLUORESCENCE

Applicant/Assignee: 3M INNOVATIVE PROPERTIES COMPANY

Application No.: 12/520402   Filing Date: 21/Dec/2007

Abstract:The invention features a dental composition containing a polycyclic aromatic compound, such as 2-ethyl 9,10-dimethoxy anthracene (EDMOA), in an amount that provides the composition with fluorescence mimicking that of natural teeth.

Priority: US20060877513P Applic. Date: 2006-12-28; WO2007US88528 Applic. Date: 2007-12-21

Inventor: CRAIG BRADLEY D [US]; KOBUSSEN GREGORY A [US]

Title: TUBULAR SHAFT INSTRUMENT

Applicant/Assignee:

Application No.: 12/444336   Filing Date: 26/Sep/2007

Abstract:The present application relates to a tubular shaft instrument for separating tissue. The invention relates to a tubular shaft instrument that results in more reliable, cleaner separation of tissue. To achieve this, in contrast to conventional cutting devices, the blade is not displaced through the fixed tissue, but glides over the latter until a complete separation is ascertained.

Priority: DE200610046919 Applic. Date: 2006-10-05; DE200610046920 Applic. Date: 2006-10-05; DE200610047204 Applic. Date: 2006-10-05; DE200610047215 Applic. Date: 2006-10-05; DE200610056405 Applic. Date: 2006-11-29; DE200610059175 Applic. Date: 2006-12-14; WO2007EP08389 Applic. Date: 2007-09-26

Inventor: HAFNER DIETER [DE]

Title: Methods for the Joint Wrapping of Bags with their Contents, Applying Machine and Packet of Bags Containing "Snack" thus Obtained

Applicant/Assignee:

Application No.: 12/439777   Filing Date: 04/Sep/2007

Abstract:Method for the joint wrapping of bags containing a product in pieces, granules or powder piled inside an elongated laminar wrapping made of termo-adherent plastic and joined at its longitudinal edges forming a sleeve closed at its bottom and at its laminar header wall with weldings, which comprises: a) making the bags laid on a conveyor go forward

b) delivering at least a first bag on a support while welding means close the laminar wrapping determining a bottom

c) partially forming a continuous laminar wrapping closed longitudinally with the shape of a sleeve with its bottom welded according to step b)

d) pushing horizontally at least the first bag of the support towards the opening of the tube that forms the sleeve

e) pushing vertically causing the joint descent of the first bag and wrapping while the sleeve is closed with seams in longitudinal sense at one of its sides

f) continuing feeding the support with bags pushing them first horizontally on the opening of the tube that forms the sleeve and then vertically for the descent of the group until the packet is complete

and y g) closing by means of transverse welding the header laminar wall of the packet formed and separate it through a cut forming at the same time the bottom of the wrapping of the next packet. Machine to carry out the method. Method for the joint wrapping of bags containing "snack" inside a laminar wrapping made of thermo-adherent plastic with the shape of a sleeve, machine for carrying out such method and packet of bags containing "snack" obtained by means of such method.

Priority: AR2006P103859 Applic. Date: 2006-09-04; AR2007P103892 Applic. Date: 2007-09-03; WO2007IB02548 Applic. Date: 2007-09-04

Inventor: CARMELO CALVANO FERRUCCHIO [AR]

Title: Novel Device

Applicant/Assignee:

Application No.: 11/778104   Filing Date: 16/Jul/2007

Abstract:A face mask comprising a filter material being a fibrous substrate, especially non-woven polypropylene or polyester, having an acidic polymer, especially of the Carbopol or Gantrez type, deposited on the fibres. The mask has an anti-viral activity against inhaled or exhaled air. A filter material suitable for such a mask, and a process for making it are also described.

Priority: GB20060014251 Applic. Date: 2006-07-18; GB20070006435 Applic. Date: 2007-04-02

Inventor: BIEDERMANN KIMBERLY [US]; DENG FRANK [US]; KING SIMON [GB]; MIDDLETON ANDREW [GB]

Title: SMOKELESS TOBACCO PRODUCTS AND PROCESSES

Applicant/Assignee:

Application No.: 12/180763   Filing Date: 28/Jul/2008

Abstract:A smokeless tobacco product is provided. A tobacco product configured for insertion into the mouth of a user of that product comprises a tobacco formulation including a granular tobacco composition enclosed within a water-permeable pouch that has been treated with a substance selected from the group consisting of: an analgesic, a buffer, a coloring, an effervescent, or an organic acid.

Priority:

Inventor: DOOLITTLE DAVID JAMES [US]; ARZONICO BARBARA WALKER [US]; CHAPMAN PAUL STUART [US]; STOKES CYNTHIA STEWART [US]

Title: SMOKELESS TOBACCO PRODUCTS AND PROCESSES

Applicant/Assignee:

Application No.: 12/180943   Filing Date: 28/Jul/2008

Abstract:A smokeless tobacco product is provided. A tobacco product configured for insertion into the mouth of a user of that product comprises a water-permeable pouch containing a tobacco formulation that includes a granular tobacco composition and miraculin.

Priority:

Inventor: GERARDI ANTHONY RICHARD [US]; COLEMAN III WILLIAM MONROE [US]; PHILLIPS PERCY DENOID [US]

Title: ORAL HYGIENE DEVICE

Applicant/Assignee: FLOSSPIK PTV LTD

Application No.: 12/527192   Filing Date: 14/Feb/2008

Abstract:An oral hygiene device (10) comprising first and second parts (46,47), the first part (46) comprising a hollow body portion which encloses dental floss (64) and the other part (47) defining a toothpick, the dental floss(64) being attached to the first and second parts (46,47), the first part (47) being separable from the second part (46) so that the parts (46, 47) can act as handles between which the dental floss (64) can be tensioned. The part (46) may have ribs (54) on at least one face for enhancing gripping and also to enable the device (10) to be used as a tongue cleaner or scraper. The first part (46) may also carry a capsule (60 which can contain a liquid such as a mouth wash or breath freshener or a solid substance such as a lozenge.

Priority: AU20070900708 Applic. Date: 2007-02-14; AU20070905473 Applic. Date: 2007-10-05; WO2008AU00180 Applic. Date: 2008-02-14

Inventor: ROEMUSS PETER ANTHONY [AU]

Title: NEURONAL EXOCYTOSIS INHIBITING PEPTIDES

Applicant/Assignee: LIPOTEC, S.A

Application No.: 12/447136   Filing Date: 24/Oct/2007

Abstract:The invention relates to peptides of general formula (I): R1-AA-R2 (I) which can regulate neuronal exocytosis, their stereoisomers and racemic or non-racemic mixtures thereof, and the cosmetically or pharmaceutically acceptable salts thereof, wherein AA is a sequence of 3 to 40 adjacent amino acids contained in the amino acid sequence of the SNAP-25 protein, R1 is selected from the group consisting of H or alkyl, aryl, aralkyl or acyl group

and R2 is selected from the group consisting of amino, hydroxyl or thiol, substituted or non-substituted with aliphatic or cyclic groups, with the condition that when R1 is H or acetyl, R2 is not non-substituted amino, hydroxyl or thiol. The invention also relates to a method of obtaining such peptides, cosmetic or pharmaceutical compositions containing them and their use to treat those conditions requiring neuronal exocytosis regulation, preferably for treating the skin.

Priority: ES20060002720 Applic. Date: 2006-10-25; WO2007ES00603 Applic. Date: 2007-10-24

Inventor: CARRENO SERRAIMA CRISTINA [ES]; PONSATI OBIOLS BERTA [ES]; VAN DEN NEST WIM [ES]; FERNANDEZ CARNEADO JIMENA [ES]; FERRER MONTIEL ANTONIO [ES]; CEBRIAN PUCHE JUAN [ES]; ALMINANA DOMENECH NURIA [ES]

Title: INJECTABLE IN SITU SELF-FORMING MINERAL-POLYMER HYBRID COMPOSITION AND USES THEREOF

Applicant/Assignee: BIOSYNTECH CANADA INC

Application No.: 12/575788   Filing Date: 08/Oct/2009

Abstract:Self-forming hybrid compositions consisting in admixed liquid and solid components enable the formation of bio-materials. The present invention proposes a) a thermo-sensitive self-forming liquid component, being water-based and containing at least a polycationic polymer such as chitosan, and an organic mono-phosphate source, which is a solution at a pH ranging from 6.5 to 7.4

b) a solid component being mineral and composed of at least one of calcium, fluoride, strontium, carbonate and phosphate salts. Solid mineral salts preferentially have a recognized bioactive potential such as the calcium phosphate salts for bones. Both solid and liquid components are admixed to form an injectable liquid slurry or pre-gelled paste that turn in situ into a hybrid uniform gel-like bio-material.

Priority: US2002-149053 Applic. Date: 2002-12-03; WO2000CA01492 Applic. Date: 2000-12-08; US19990169954P Applic. Date: 1999-12-09

Inventor: CHAPUT CYRIL [CA]; CHENITE ABDELLATIF [CA]

Title: NOVEL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF

Applicant/Assignee: RENOVIS, INC

Application No.: 11/991485   Filing Date: 01/Sep/2006

Abstract:Compounds are disclosed that have a formula represented by the following (1), the compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Priority: US20050713231P Applic. Date: 2005-09-01; US20050714676P Applic. Date: 2005-09-07; US20050717463P Applic. Date: 2005-09-15; US20050753957P Applic. Date: 2005-12-23; US20050754223P Applic. Date: 2005-12-28; WO2006US34236 Applic. Date: 2006-09-01

Inventor: KINCAID JOHN [US]; CAO YEYU [US]; KAUB CARL [US]; LONERGAN DAVID [US]; KELLY MICHAEL G [US]

Title: PHOTOCURABLE COMPOSITIONS COMPRISING A PHOTOINITIATOR OF THE PHENYLGLYOXYLATE TYPE

Applicant/Assignee:

Application No.: 12/442779   Filing Date: 24/Sep/2007

Abstract:The invention provides a uv-curable colored composition, comprising (a) at least one selected ethylenically unsaturated photopolymerizable compound

(b) at least one selected curing agent

and (c) at least one selected colorant.

Priority: EP20060121655 Applic. Date: 2006-10-03; WO2007EP60093 Applic. Date: 2007-09-24

Inventor: ROGERS JONATHAN [US]; BENKHOFF JOHANNES [CH]; POWELL KARIN [DE]; JUNG TUNJA [DE]; DIETLIKER KURT [CH]; HAYOZ PASCAL [CH]; BIRBAUM JEAN-LUC [CH]; VOGEL THOMAS [DE]; HUESLER RINALDO [CH]

Title: Dental compositions comprising cisacrylamides and use thereof

Applicant/Assignee:

Application No.: 12/586789   Filing Date: 28/Sep/2009

Abstract:The invention concerns a dental composition comprising bisacrylamides that are polymerizable by free-radical polymerization and by Michael-addition polymerization with amines. The application of polymerization and addition polymerization with amines opens the possibility to completely reacted materials that have no oxygen inhibited layers. The claimed bisacrylamides have an improved hydrolytic stability.

Priority: US2007-699597 Applic. Date: 2007-01-29; US2002-308564 Applic. Date: 2002-12-03; US2001-925173 Applic. Date: 2001-08-09; US20010310572P Applic. Date: 2001-08-07; US20000224670P Applic. Date: 2000-08-11

Inventor: WALZ UWE [DE]; KLEE JOACHIM E [DE]

Title: Dental adhesive composition

Applicant/Assignee:

Application No.: 12/386022   Filing Date: 13/Apr/2009

Abstract:Dental composition comprising an aqueous mixture containing (i) a polymerizable acidic phosphoric acid ester monomer of the following formula (A): wherein a is an integer of from 1 to 10

R1 represents a hydrogen atom or a moiety of the following formula (Y) wherein X independently represent an oxygen atom, a sulfur atom, or a group NR, wherein R may be a hydrogen atom, a C1-6 alkyl group or an acyl group

L represents an (a+b)-valent organic residue containing 1 to 20 carbon atoms and optionally including ether, thioether or amino groups or further acidic groups, whereby the carbon atoms comprise at least a+b carbon atoms selected from primary and secondary aliphatic carbon atoms, secondary alicyclic carbon atoms, and aromatic carbon atoms, each of said a+b carbon atoms linking a phosphate or 2-(oxaallyl) derivative group

b is an integer of from 1 to 10

R2 which may be the same or different, independently may be hydrogen, an allyl group or a moiety R1 wherein b is 1

provided that at least one of R1 and R2 is not hydrogen

(ii) one or more polymerizable N-substituted alkyl acrylic or acrylic acid amide monomers

(iii) an organic water-miscible solvent and/or water

(iv) a polymerization initiator

(v) an inhibitor and/or a stabilizer

(vi) optionally an organic or inorganic acid

and (vii) optionally a filler and/or a fluoride releasing compound.

Priority: WO2007EP08764 Applic. Date: 2007-10-09; EP20060021540 Applic. Date: 2006-10-13

Inventor: KLEE JOACHIM E [DE]; LEHMANN UWE [DE]

Title: METHOD AND APPARATUS FOR TREATING AN ACUTE MYOCARDIAL INFARCTION

Applicant/Assignee:

Application No.: 12/506620   Filing Date: 21/Jul/2009

Abstract:A method and apparatus for treating an acute myocardial infarction is provided. The apparatus comprises an ultrasound catheter that can be inserted into the esophagus to deliver ultrasound energy to the heart and coronary vasculature. The ultrasound energy can enhance the effect of an intravenously administered thrombolytic drug on a blood clot within the coronary vasculature. The ultrasound catheter can have a means for promoting acoustic coupling with the esophagus and a means for preventing or reducing aspiration of fluids into the lungs.

Priority: US20080082443P Applic. Date: 2008-07-21

Inventor: WILCOX ROBERT L [US]

Title: SELF-CONTAINED DISPOSABLE CHANGING MAT

Applicant/Assignee:

Application No.: 12/448122   Filing Date: 03/Dec/2007

Abstract:A self-contained disposable changing mat (2) that is one piece and liquid proof and comprises at least two layers (4, 6) each with an absorbent working area (8) from which a part of a person is able to be attended to, a waste disposal bag (10) that hangs down when the self-contained disposable changing mat (2) is used on a raised work surface (12), the waste disposal bag (10) having a mouth (18) that gapes open so that the waste disposal bag (10) is ready for receiving waste produced during use of the self-contained disposable changing mat (2), the layers (4, 6) being partially separable from each other and connected together in or adjacent to the mouth (18) of the waste disposal bag (10) whereby an upper used layer is able to be placed in the waste disposal bag (10) in order to expose a clean lower layer available for further use during treatment of the person, and sealing means (20)

for sealing the waste disposal bag (10) after use thereby containing the waste.

Priority: GB20060025105 Applic. Date: 2006-12-15; GB20070002554 Applic. Date: 2007-02-09; WO2007GB04619 Applic. Date: 2007-12-03

Inventor: GOODMAN MICHAEL STEPHEN [GB]; MOIR GRAEME CHRISTOPHER [GB]

Title: PHOSPHATE COMPOUND, METAL SALT THEREOF, DENTAL MATERIAL AND DENTAL COMPOSITION

Applicant/Assignee: MITSUI CHEMICALS, INC

Application No.: 12/441468   Filing Date: 26/Sep/2007

Abstract:The invention provides a phosphate compound having an unsaturated double bond and a metal salt thereof

a dental material containing a phosphate compound having an unsaturated double bond and/or a metal salt thereof

and a dental composition containing a phosphate compound having an unsaturated double bond and/or a metal salt thereof. The phosphate compound of the invention provides a dental material and a dental composition such as a bonding material, adhesive material and a dental luting agent that are highly stable during storage, convenient for handling, and that exhibit higher adhesiveness and bond durability.

Priority: JP20060261598 Applic. Date: 2006-09-27; WO2007JP68639 Applic. Date: 2007-09-26

Inventor: TAKAGI MASATOSHI [JP]; OTSUJI ATSUO [JP]; NAGATOMO AKINORI [JP]; SUESUGI KOUJI [JP]

Title: CHILD-RESISTANT CANISTER

Applicant/Assignee: BERRY PLASTICS CORPORATION

Application No.: 12/507557   Filing Date: 22/Jul/2009

Abstract:A child-resistant canister includes a container and a closure configured to mount on the container to close an opening into an interior region formed in the container. The closure includes a lid and a lid anchor coupled to the lid. The lid anchor is configured to mate with a closure retainer included in the container to retain the closure in a mounted position on the container.

Priority: US20080083419P Applic. Date: 2008-07-24

Inventor: BEECROFT W GORDON [US]

Title: Three Seal Sachet With A Dispensing Device

Applicant/Assignee:

Application No.: 12/533023   Filing Date: 31/Jul/2009

Abstract:A three seal sachet and method of manufacturing the sachet. The sachet includes a film having first and second longitudinal sheet edges and opposed first and second sheet faces. The film is folded to form opposed first and second sachet faces where the film is sealed to itself along marginal portions of the first and second longitudinal sheet edges on the first sheet face thereby forming a tube with a longitudinal seal on the second sachet face. First and second transverse seals bond the film along the marginal portions of the first and second transverse edges of the sheet, thereby closing the tube at each end. The sachet also includes a dispensing device disposed on the first or second face. The disposed device includes a flange which is inserted into the first sachet face and secures the device to the sachet and a dispensing orifice enabling product to be dispensed from the sachet.

Priority: EP20080161590 Applic. Date: 2008-07-31

Inventor: AGER COLIN DENNIS [GB]; BURFIEND JAMES RICHARD [GB]; CAUWOOD PETER DAVID [GB]; CUCKNELL ALAN JOHN EDWARD [GB]; THOMPSON KEITH PAUL [GB]

Title: DRUG TARGET FOR PREVENTING AND TREATING PERIODONTAL DISEASE, IMPROVING HEALING OF PERIODONTAL WOUNDS AND PROMOTING ORAL HEALTH

Applicant/Assignee: OMNIO HEALER AB

Application No.: 12/439516   Filing Date: 28/Aug/2007

Abstract:The present invention relates to the use of a component of the plasminogen-activating pathway and use of compounds which have the capacity to activate plasminogen directly or via the plasminogen-activating pathway, for prophylaxis, prevention and treatment of periodontal disease including peri-implantitis, healing of periodontal wounds and prompting oral health in human and non-human subjects.

Priority: US20060823665P Applic. Date: 2006-08-28; US20070944111P Applic. Date: 2007-06-15; WO2007SE50586 Applic. Date: 2007-08-28

Inventor: NY TOR [SE]; LI JINAN [SE]; GUO YONGZHI [SE]; LINDH TOMAS [SE]

Title: Preparation of recombinant rotavirus proteins in milk of transgenic non-human mammals

Applicant/Assignee: BIOPROTEIN TECHNOLOGIES

Application No.: 10/591538   Filing Date: 04/Mar/2005

Abstract:The present invention relates to a non-human transgenic mammal whose genome comprises: i) a first transgene comprising a mammary gland specific transcriptional control region operably linked to cDNA encoding a rotavirus protein selected from VP2, VP4, VP6 and VP7 and wherein said cDNA comprises a secretion signal sequence

ii) at least a second transgene comprising a mammary gland specific transcriptional control region operably linked to cDNA encoding another said rotavirus protein and wherein said cDNA comprises a secretion signal sequence

and wherein said rotavirus proteins are secreted separately and auto-assembled in milk in rotavirus like particles (VLP) or aggregates of said rotavirus proteins.

Priority: EP20040290589 Applic. Date: 2004-03-04; WO2005IB00896 Applic. Date: 2005-03-04

Inventor: COHEN JEAN [FR]; SOLER ERIC [FR]; HOUDEBINE LOUIS-MARC [FR]; SCHWARTZ-CORNIL ISABELLE [FR]; FOURGEUX CYNTHIA [FR]; PAREZ NATHALIE [FR]; GARBARG-CHENON ANTOINE [FR]; COHEN IVAN [FR]; COHEN SERGE [FR]

Title: POLYMER MATRIX, USES THEREOF AND A METHOD OF MANUFACTURING THE SAME

Applicant/Assignee: BACTIGUARD AB

Application No.: 12/303554   Filing Date: 05/Jun/2007

Abstract:The present invention relates to a polymer matrix, characterized in that it comprises a) an electron donating constituent and b) metal particles comprising at least one metal chosen from palladium, gold, ruthenium, rhodium, osmium, iridium, and platinum. The polymer matrix makes it possible to improve the biocompatibility and antimicrobial properties of substrates coated with said polymer matrix.

Priority: US20060811305P Applic. Date: 2006-06-05; WO2007SE00543 Applic. Date: 2007-06-05

Inventor: OHRLANDER MATTIAS [SE]; SOEDERVALL BILLY [SE]

Title: Low fat meat compositions capable of high temperature cooking

Applicant/Assignee:

Application No.: 12/587477   Filing Date: 08/Oct/2009

Abstract:Low fat meat compositions are provided that contain ingredients that act synergistically, allowing the compositions to successfully cook and surface char at temperatures of 700 degrees Fahrenheit and above, in one step, consisting of meat, water, textured protein concentrate, water binders, a fat binder/emulsifier/dispersion agent, and salt. These compositions reproduce the mouth-feel, taste, and texture of 100% meat char-broiled in the same manner. The invention makes possible high temperature cooking of meat compositions at lower fat content, far less than 19%, which was not possible prior to this invention. The preferred embodiment reduces the percentage of fat to a range of 9-11.25%, plus a negligible amount of fat from the non-meat ingredients, and this compares very favorably to 22% fat content stated as the optimum requirement, by the Nieco Company, manufacturer of high temperature broilers. The benefits of the invention are reduced fat content as a dietary consideration, food that is easier to digest and maximized for taste, capable of being cooked in one easy low cost step, a substantial reduction of greenhouse gases, particulate matter and volatile organic compounds caused by char-cooking of meats containing higher fat content, and less overall need for animal meat, which translates into reduced greenhouse gases cause by live animals. The invention contributes to worldwide efforts to reduce global warming.

Priority: US2008-008878 Applic. Date: 2008-01-15

Inventor: STRAM MICHAEL A [US]; STRAM JR THEODORE M [US]

Title: Process for Coating Dental Tape

Applicant/Assignee:

Application No.: 12/185337   Filing Date: 04/Aug/2008

Abstract:This present invention relates to a process for evenly and uniformly coating textured tape (e.g., dental tape).

Priority: US20080085345P Applic. Date: 2008-07-31

Inventor: OCHS HAROLD [US]; CHODZKO JOHN [US]

Title: Anti-microbial orthodontic compositions and appliances and methods of production and use thereof

Applicant/Assignee:

Application No.: 12/460046   Filing Date: 13/Jul/2009

Abstract:The presently disclosed and claimed invention is directed to anti-microbial orthodontic apparatus and anti-microbial orthodontic compositions comprising an effective amount of a selenium compound, kits containing same, and methods of producing and using said anti-microbial orthodontic apparatus and anti-microbial orthodontic compositions.

Priority: US2006-439751 Applic. Date: 2006-05-24; US20090147041P Applic. Date: 2009-01-23; US20090147032P Applic. Date: 2009-01-23; US20090144422P Applic. Date: 2009-01-13; US20090144147P Applic. Date: 2009-01-12; US20090144144P Applic. Date: 2009-01-12; US20050683847P Applic. Date: 2005-05-24; US20050730335P Applic. Date: 2005-10-26; US20060802670P Applic. Date: 2006-05-23

Inventor: REID TED [US]; SPALLHOLZ JULIAN [US]; DEVANATHAN THIRUMAL N [US]; MOSLEY THOMAS [US]

Title: CHEMICALLY ACTIVATED DENTAL BLEACHING TRAYS

Applicant/Assignee: ULTRADENT PRODUCTS, INC

Application No.: 12/183303   Filing Date: 31/Jul/2008

Abstract:Dental treatment trays and strips used to deliver a dental bleaching composition to a person's teeth are formed from a moisture resistant barrier material and include a bleaching agent destabilizer disposed on an inner treatment surface of the barrier layer that is positioned against the person's teeth during use. The bleaching agent destabilizer may be compounded with the moisture resistant material or otherwise disposed relative to the barrier layer so that at least some destabilizer is positioned on the inner treatment surface of the tray or strip so as to contact the dental bleaching composition during use.

Priority:

Inventor: LEWIS PAUL E [US]; ANDERSEN SCOT N [US]; ALLRED PETER M [US]; FISCHER DAN E [US]

Title: Dispensing syringe having multiple barrels for discharging a dental composition

Applicant/Assignee:

Application No.: 12/587417   Filing Date: 07/Oct/2009

Abstract:A dispensing syringe for dispensing a multi-component dental composition, preferably a two component composition, is provided. The syringe includes a syringe body with multiple elongated barrels for storing the components of the composition

a threaded plunger rod assembly

and a rotatable, threaded connector knob. Preferably, the syringe body has a double-barrel structure and the plunger rod assembly includes two plunger rods that slide within the barrels. The threaded knob has a through-bore with a continuous internal thread for engaging the outer threads of the first and second plunger rods. A dental practitioner manually rotates the knob to displace the first and second plunger rods and discharge the components. The dispensing syringe may further include a dispensing tip containing a static mixing element for mixing the components and dispensing the mixed composition.

Priority: US2005-238374 Applic. Date: 2005-09-29

Inventor: PIERSON PAUL R [US]

Title: Dental device for use in the obturation of a root canal

Applicant/Assignee:

Application No.: 12/587347   Filing Date: 06/Oct/2009

Abstract:Kit-of-parts containing (i) a dental device for use in the obturation of a root canal which comprises a tapered obturating point portion integrally connected at the distal end of a functional portion, whereby the functional portion comprises (a) a neck portion adjacent to the obturating point portion, and (b) a handle portion, and (ii) a dental sealant composition, wherein the dental device is made of a material obtainable by curing a composition containing one or more curable components contained in the dental sealant.

Priority: WO2006EP00963 Applic. Date: 2006-02-03; US2007-890411 Applic. Date: 2007-08-06; EP20050002423 Applic. Date: 2005-02-04; EP20060706627 Applic. Date: 2006-02-03

Inventor: GUTZNER ANDREAS E [DE]; KLEE JOACHIM E [DE]

Title: Mvl, an antiviral protein from a cyanobacterium

Applicant/Assignee: THE GOVERNMENT OF THE USA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

Application No.: 10/592422   Filing Date: 09/Mar/2005

Abstract:The present invention relates, e.g., to an isolated polypeptide from a cyanobacterium, Microcystis viridis, which binds specifically to an oligosaccharide comprising the tetrasaccharide Man-alpha-(1->6)Man-beta (1->4) GlcNAc-beta(1->4)GlcNAc. The polypeptide can be obtained, for example, from a cell that expresses a recombinant nucleic acid that encodes a MVL-like polypeptide. The invention also relates to an isolated polypeptide comprising one or more copies of the sequence GPLWSNXEAQXXGPX (SEQ ID NO: 1) and/or one or more copies of the sequence FTGQWXTXVEXXMSV (SEQ ID NO: 2), wherein the polypeptide binds specifically to the above-mentioned oligosaccharide. Conjugates comprising such polypeptides and an effector molecule are also disclosed, as are methods of using such polypeptides or conjugates, e.g., for inhibiting infection by a virus, such as HIV, or for removing a virus, such as HIV, from a sample, such as a bodily fluid or an inanimate object.

Priority: US20040551058P Applic. Date: 2004-03-09; WO2005US07703 Applic. Date: 2005-03-09

Inventor: BEWLEY CAROLE A [US]

Title: 1,4,5,6,7,8-HEXAHYDRO-1,2,5-TRIAZA-AZULENE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

Applicant/Assignee: ACTELION PHARMACEUTICALS LTD

Application No.: 12/439303   Filing Date: 27/Aug/2007

Abstract:The invention relates to 1,4,5,6,7,8-hexahydro-1,2,5-triaza-azulene derivatives and their use as orexin receptor antagonists.

Priority: WO2006IB52984 Applic. Date: 2006-08-28; WO2007IB53417 Applic. Date: 2007-08-27

Inventor: AISSAOUI HAMED [FR]; BOSS CHRISTOPH [CH]; GUDE MARKUS [CH]; KOBERSTEIN RALF [DE]; SIFFERLEN THIERRY [FR]

Title: Bridged, Bicyclic Heterocyclic or Spiro Bicyclic Heterocyclic Derivatives of Pyrazolo[1, 5-A]Pyrimidines, Methods for Preparation and Uses Thereof

Applicant/Assignee: WYETH

Application No.: 12/393565   Filing Date: 26/Feb/2009

Abstract:Compounds of formula A: and pharmaceutically acceptable salts thereof are described, which selectively inhibit Raf kinase activity and are useful for treating disorders mediated by Raf kinases.

Priority: US20080067843P Applic. Date: 2008-02-29; US20080116809P Applic. Date: 2008-11-21

Inventor: LEVIN JEREMY IAN [US]; HOPPER DARRIN WILLIAM [US]; TORRES NANCY [US]; DUTIA MINU DHANJISHA [US]; BERGER DAN MAARTEN [US]; WANG XIAOLUN [US]; DI GRANDI MARTIN JOSEPH [US]; ZHANG CHUNCHUN [US]; DUNNICK ALEJANDRO LEE [US]

Title: Anesthetic compositions and methods of use

Applicant/Assignee: ALPHA SYNERGY DEVELOPMENT, INC

Application No.: 12/460954   Filing Date: 27/Jul/2009

Abstract:The invention generally relates to anesthetic compositions comprising low doses of a selective a-2 adrenergic receptor agonists in combination with anesthetic agents. The invention also relates to methods of using these compositions

in particular, the use of these compositions in humans to enhance the efficacy of a local peripheral anesthetic injection. The compositions and the methods are particularly useful in regional block anesthetic injections, and more particularly, in dental anesthetic injections.

Priority: US20080137714P Applic. Date: 2008-08-01; US20080192777P Applic. Date: 2008-09-22; US20080203120P Applic. Date: 2008-12-18; US20090207481P Applic. Date: 2009-02-12

Inventor: HORN GERALD [US]

Title: NOVEL CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS

Applicant/Assignee: NEURO SEARCH A/S

Application No.: 12/520236   Filing Date: 18/Dec/2007

Abstract:This invention relates to novel chromen-2-one derivatives of Formula (I) useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

Priority: DK20060001678 Applic. Date: 2006-12-20; US20060875806P Applic. Date: 2006-12-20; WO2007EP64130 Applic. Date: 2007-12-18

Inventor: PETER DAN [CH]; REDROBE JOHN PAUL [DK]; OLSEN GUNNAR M [DK]; NIELSEN ELSEBET OESTERGAARD [DK]

Title: TUBULAR SHAFT INSTRUMENT

Applicant/Assignee:

Application No.: 12/444356   Filing Date: 26/Sep/2007

Abstract:The invention relates to tubular shaft instruments, which are provided with a handle, a tubular shaft and a tool head. The tool head usually has two mouth parts, which can be displaced in relation to one another for gripping and fixing tissue. The invention discloses a slotted guide system for forming the articulation, said system having a virtual fulcrum outside the tubular shaft instrument.

Priority: DE200610046919 Applic. Date: 2006-10-05; DE200610046920 Applic. Date: 2006-10-05; DE200610047204 Applic. Date: 2006-10-05; DE200610047215 Applic. Date: 2006-10-05; DE200610056405 Applic. Date: 2006-11-29; DE200610059175 Applic. Date: 2006-12-14; WO2007EP08386 Applic. Date: 2007-09-26

Inventor: HAFNER DIETER [DE]

Title: RESPIRATORY MASK INTERFACE

Applicant/Assignee:

Application No.: 12/535823   Filing Date: 05/Aug/2009

Abstract:An interface for a respiratory mask includes a first flexible member and a second flexible member. The first flexible member is configured to be accommodated on a user's face. The first flexible member circumscribes one or more portions of the user's face. The second flexible member is configured complimentary to the first flexible member to circumscribe the one or more portions of the user's face. Further, the second flexible member is attached with the first flexible member to configure at least one hollow enclosure therebetween. In an embodiment, a hollow enclosure of the at least one hollow enclosure is filled with a cooling gel for cooling the user's face. The second flexible member is configured to accommodate the respiratory mask thereon.

Priority: US20080137927P Applic. Date: 2008-08-05

Inventor: STEWART RUTH [CA]

Title: LIQUID DISPENSER OR WATER PURIFICATION UNIT WITH ANTIMICROBIAL MOUTHPIECE OR HOUSING

Applicant/Assignee:

Application No.: 12/448075   Filing Date: 06/Dec/2007

Abstract:Liquid dispenser or water purification unit with a housing and a mouthpiece configured for contact with the mouth of a person, wherein at least part of the housing or part of the mouthpiece or parts of both have an antimicrobial surface.

Priority: WO2007DK00532 Applic. Date: 2007-12-06; US20060873440P Applic. Date: 2006-12-07

Inventor: FRANDSEN MIKKEL VESTERGAARD [CH]

Title: MODULAR WATER PURIFICATION UNIT

Applicant/Assignee:

Application No.: 12/448078   Filing Date: 06/Dec/2007

Abstract:A portable water purification unit in the form of a stiff, tubular housing with a first opening at a first end for entrance of water into the tubular housing and a mouthpiece at an opposite end. The tubular housing comprises at least a first module and a connected second tubular module containing mutually different water purifying granular resins. The first module or the second module have at least one water permeable mesh with a mesh size smaller than the grain size of the resins for preventing mixing of the resins.

Priority: WO2007DK00531 Applic. Date: 2007-12-06; US20060873441P Applic. Date: 2006-12-07

Inventor: VESTERGAARD FRANDSEN MIKKEL [CH]

Title: PROCEDURE FOR MANUFACTURING BOTTLES CONTAINING FLUIDS, PARTICULARLY COSMETIC, MEDICAL, PHARMACEUTICAL PRODUCTS OR THE LIKE, AND RELATIVE SYSTEM AND BOTTLES

Applicant/Assignee:

Application No.: 12/450352   Filing Date: 18/Mar/2008

Abstract:The procedure for manufacturing bottles (2) containing fluids, particularly-cosmetic, medical, pharmaceutical products or the like, comprises a forming phase of a hollow body (4) having a dispensing mouth (5) that can be closed by means of removable closing means (8) comprising shutter means (10) that can be coupled with the mouth, the closing means being made in a single body with the hollow body. During the forming phase, the closing means are arranged with the shutter means substantially transversal to the direction of coupling with the dispensing mouth. After the forming phase a coupling" phase is contemplated of the shutter means with the dispensing mouth.

Priority: IT2007MO00104 Applic. Date: 2007-03-23; WO2008IB00647 Applic. Date: 2008-03-18

Inventor: FONTANA ANTONIO [IT]

Title: COMPACT GAS LIGHTING DEVICE FOR AN ELECTRIC HOUSEHOLD APPLIANCE, IN PARTICULAR A COOKING DEVICE

Applicant/Assignee: ITW INDUSTRIAL COMPONENTS S.R.L. CON UNICO SOCIO

Application No.: 12/529329   Filing Date: 25/Mar/2008

Abstract:A gas lighting device including: a body formed by an electrically insulating material and carrying a plurality of high-voltage outputs for the connection to spark generating means

a transformer accommodated in the body and including a primary winding wound about and carried by a ferromagnetic material core, a carrying element formed by an electrically insulating material and designed to contain within a tubular drum thereof the primary winding, and a secondary winding consisting of a plurality of coils externally carried by the drum of the carrying element, electrically insulated from the primary winding and essentially coaxial with the latter

the core is bar-shaped and accommodated inside the carrying element and the drum directly supports also the high-voltage outputs, which are integrally obtained on the drum so as to form therewith the carrying element and laterally overhangingly protrude from the drum.

Priority: IT2007TO00215 Applic. Date: 2007-03-26; WO2008IB00702 Applic. Date: 2008-03-25

Inventor: PIANEZZE DANIELE [IT]; ALEARDI MASSIMO [IT]

Title: Detection of HIV-1 Infection

Applicant/Assignee:

Application No.: 11/922404   Filing Date: 15/Jun/2006

Abstract:This invention provides methods for to the use of the difference in phosphodiester (PDE)/phosphomonoester (PME) ratio in biological fluids, as an analytical criterion to image both the presence and degree of viral infection in-vivo.

Priority: US20050690489P Applic. Date: 2005-06-15; US20050690491P Applic. Date: 2005-06-15; WO2006US23346 Applic. Date: 2006-06-15

Inventor: ROZMYSLOWICZ TOMASZ [US]; WROBLEWSKI KRZYSZTOF [US]; GAULTON GLEN N [US]

Title: COMPOSITION AND METHOD FOR DETECTION OF DEMINERALISATION

Applicant/Assignee:

Application No.: 12/520128   Filing Date: 21/Dec/2007

Abstract:The invention relates to a composition for the detection of tooth demineralisation. More specifically, the invention concerns a composition comprising a complex capable of producing an optical signal characteristic of the presence of free ions, the pharmaceutical uses of such a composition, and methods and a kit for the detection of active demineralisation at tooth surfaces using such a composition.

Priority: GB20060025678 Applic. Date: 2006-12-21; WO2007GB04944 Applic. Date: 2007-12-21

Inventor: PERFECT EMMA [GB]; LONGBOTTOM CHRIS [GB]

Title: EDIBLE FOAM PRODUCT FOR THE TREATMENT OR PREVENTION OF OBESITY

Applicant/Assignee:

Application No.: 12/445478   Filing Date: 01/Oct/2007

Abstract:The present invention relates to an edible foam product that can advantageously be used in the treatment or prevention of obesity. More particularly, the present invention provides an edible foam product of pourable or spoonable consistency having an overrun of at least 100%, said foam product containing at least 60 wt. % of water, from 1 to 7 wt. % of protein and from 1 to 20 wt. % of carbohydrates, and further being characterised by a high in-mouth stability as evidenced by a reduction in overrun of less than 35% under in-mouth shear conditions and a high gastric stability as evidenced by a t 1/2 >30 minutes, t 1/2 representing the time needed to achieve a reduction in overrun of 50% under gastric conditions. Another aspect of the invention relates to the use of an edible foam product in the treatment or prevention of overweight or obesity, said edible foam product having a pourable or spoonable consistency, an overrun of at least 100% and a high gastric stability as evidenced by t 1/2 >30 minutes. Yet another aspect of the invention concerns a pressurised container holding an edible liquid composition and a propellant, which liquid composition can be released from the container by activating a valve to produce an edible foam product having a pourable or spoonable consistency, an overrun of at least 100% and a high gastric stability as evidenced by t 1/2 >30 minutes.

Priority: EP20060122405 Applic. Date: 2006-10-17; WO2007EP60354 Applic. Date: 2007-10-01

Inventor: COX ANDREW RICHARD [GB]; DE GROOT PETRUS WILHELMUS N [NL]; MELNIKOV SERGEY MICHAILOVICH [NL]; STOYANOV SIMEON DOBREV [NL]

Title: GRINDING METHOD FOR THE MANIPULATION OR PRESERVATION OF CALCIUM PHOSPHATE HYBRID PROPERTIES

Applicant/Assignee:

Application No.: 12/186940   Filing Date: 06/Aug/2008

Abstract:A solid state method of encouraging the physical interfacing of an organic component to a substantially crystalline inorganic component, including adding predetermined amounts of a substantially crystalline inorganic precursor and a predetermined amount of an organic precursor to yield an admixture, maintaining the admixture in a substantially liquid-free environment, and impacting the precursors together with sufficient energy to fuse the precursors into hybrid compounds. The so-formed hybrid compounds substantially retain the long range crystalline order characteristics of the substantially crystalline inorganic precursor.

Priority:

Inventor: KARLINSEY ROBERT L [US]

Title: PERSONAL CARE AND COSMETICS COMPOSITIONS COMPRISING BIOLOGICALLY-BASED MONO AND DI ESTERS

Applicant/Assignee:

Application No.: 12/579538   Filing Date: 15/Oct/2009

Abstract:Personal care compositions comprising esters of 1,3-propanediol and acceptable carriers are provided. The esters can have at least 3% biobased carbon, and the compositions can further comprise 1,3-propanediol that is biologically-derived. Also provided are processes for producing personal care compositions comprising esters of 1,3-propanediol and acceptable carriers. The processes comprise providing biologically produced 1,3-propanediol, contacting the 1,3-propanediol with organic acids, which produces the esters, recovering the esters, and incorporating the esters into personal care formulations. Also provided are processes of making a personal care composition comprising providing an ester of 1,3 propanediol and mixing the ester with an acceptable carrier to form a personal care composition.

Priority: US2007-705227 Applic. Date: 2007-02-12; US20060772471P Applic. Date: 2006-02-10; US20060772194P Applic. Date: 2006-02-10; US20060772193P Applic. Date: 2006-02-10; US20060772111P Applic. Date: 2006-02-10; US20060772120P Applic. Date: 2006-02-10; US20060772110P Applic. Date: 2006-02-10; US20060772112P Applic. Date: 2006-02-10; US20060846948P Applic. Date: 2006-09-25; US20060853920P Applic. Date: 2006-10-24; US20060859264P Applic. Date: 2006-11-15; US20060872705P Applic. Date: 2006-12-04; US20070880824P Applic. Date: 2007-01-17

Inventor: FENYVESI GYORGYI [US]; WEHNER ANN [US]; JOERGER MELISSA [US]; POLADI RAJA HARI PRASAD R [US]

Title: COMPOSITIONS AND METHODS FOR PRODUCING PLURIPOTENT CELLS FROM ADULT TESTIS

Applicant/Assignee:

Application No.: 12/092547   Filing Date: 02/Nov/2006

Abstract:The present application describes a method of producing embryonic stem cell (ESC)-like cells derived from adult mammalian testis. Furthermore, the application describes to a method of producing embryoid bodies from ESC-like cells as well as a method of producing a tissue and/or a differentiated cell from the ESC-like cell or the embryoid body. In addition, an ESC-like cell, an embryoid body and/or differentiated cell and/or tissue obtainable by said methods and pharmaceutical preparations containing the same are provided. Finally, the application describes to the use of these products for medical treatments and the preparation of pharmaceutical compositions for medical treatments.

Priority: US20050732132P Applic. Date: 2005-11-02; WO2006EP10529 Applic. Date: 2006-11-02

Inventor: GUAN KAOMEI [DE]; HASENFUSS GERD [DE]; NAYERNIA KARIM [DE]; ENGEL WOLFGANG [DE]

Title: PYRIMIDINE DERIVATIVES FOR THE PREVENTION OF HIV INFECTION

Applicant/Assignee:

Application No.: 12/567051   Filing Date: 25/Sep/2009

Abstract:This invention concerns the use of a compound for the manufacture of a medicament for the prevention of HIV infection via sexual intercourse and related intimate contact between partners, wherein the compound is a compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein the ring containing -a1=a2-a3=a4- and -b1=b2-b3=b4- represents phenyl, pyridyl, pyrimidinyl, pirazinyl, pyridazinyl

n is 0 to 5

m is 1 to 4

R1 is hydrogen

aryl

formyl

C1-6alkylcarbonyl

C1-6alkyl

C1-6alkyloxycarbonyl

substituted C1-6alkyl, C1-6alkylcarbonyl, C1-6alkyloxycarbonyl, C1-6alkylcarbonyloxy

substituted C1-6alkyloxyC1-6alkylcarbonyl

R2 is hydroxy, halo, optionally substituted C1-6alkyl, C3-7cycloalkyl, optionally substituted C2-6alkenyl, optionally substituted C2-6alkynyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, -S(-O)pR6, -NH-S(-O)pR6, -C(-O)R6, -NHC(-O)H, -C(-O)NHNH2, -NHC(-O)R6, -C(-NH)R6 or a 5-membered heterocycle

X1 is -NR5-, -NH-NH-, -N-N-, -O-, -C(-O)-, C1-4alkanediyl, -CHOH-, -S-, -S(-O)p-, -X2-C1-4alkanediyl- or -C1-4alkanediyl-X2-

R3 is NHR13

NR13R14

-C(-O)-NHR13

-C(-O)-NR13R14

-C(-O)-R15

-CH-N-NH-C(-O)-R16

substituted C1-6alkyl

optionally substituted C1-6alkyloxyC1-6alkyl

substituted C2-6alkenyl

substituted C2-6alkynyl

C1-6alkyl substituted with hydroxy and a second substituent

-C(-N-O-R8)-C1-4alkyl

R7

or -X3-R7

R4 is halo, hydroxy, C1-6alkyl, C3-7cycloalkyl, C1-6alkyloxy, cyano, nitro, polyhaloC1-6alkyl, polyhaloC1-6alkyloxy, aminocarbonyl, C1-6alkyloxycarbonyl, C1-6alkylcarbonyl, formyl, amino, mono- or di(C1-4alkyl)amino

and pharmaceutical compositions comprising them.

Priority: WO2003EP01291 Applic. Date: 2003-02-07; US2004-544735 Applic. Date: 2004-02-04; WO2004EP01011 Applic. Date: 2004-02-04

Inventor: HEERES JAN [BE]; LEWI PAULUS JOANNES [BE]; JANSSEN PAUL ADRIAAN JAN [BE]; ARTS FRANK XAVIER JOZEF HERWIG [BE]; DE JONGE MARC RENE [NL]; KOYMANS LUCIEN MARIA HENRICUS [BE]; DAEYAERT FREDERIK FRANS DESIRE [BE]; VINKERS HENDRIK MAARTEN [BE]; GULLEMONT JEROME EMILE GEORGES [FR]; PASQUIER ELISABETH THERESA JEANNE [FR]

Title: Human Anti-NGF Neutralizing Antibodies as Selective NGF Pathway Inhibitors

Applicant/Assignee: AMGEN, INC MEDAREX, INC

Application No.: 12/576522   Filing Date: 09/Oct/2009

Abstract:This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.

Priority: US2008-277919 Applic. Date: 2008-11-25; US2004-891658 Applic. Date: 2004-07-15; US2007-767326 Applic. Date: 2007-06-22; US20030487431P Applic. Date: 2003-07-15

Inventor: WILD JR KENNETH D [US]; TREANOR JAMES J S [US]; HUANG HAICHUN [US]; INOUE HEATHER [US]; ZHANG TIE J [US]; MARTIN FRANK [US]

Title: Center-Filled Chewing Gum Product For Dental Care

Applicant/Assignee:

Application No.: 12/573726   Filing Date: 05/Oct/2009

Abstract:A center-filled chewing gum product includes functional agents and a chewing gum substance enclosing a center-filling, wherein the center-filling includes toothpaste and the functional agents include at least one anti-plaque agent.

Priority: WO2007DK00175 Applic. Date: 2007-04-04

Inventor: MIKKELSEN RIKKE [DK]; PORSGAARD TANIA KJOELHEDE [DK]; BREINDAL BIRGITTE KRINGELUM [DK]

Title: Universal Template Enabling Drilling and Placing a Dental Implant Into A Patient's Jaw

Applicant/Assignee:

Application No.: 12/538206   Filing Date: 10/Aug/2009

Abstract:An apparatus for drilling into a patient's jaw, the apparatus comprising: a gel template

a cylinder embedded in the gel template

and a support arranged to fixate the gel template and the therein embedded cylinder in respect to the jaw, wherein the gel template comprises a gel selected to harden responsive of electromagnetic radiation, wherein the cylinder is arranged to allow drilling into the jaw, and wherein the cylinder is positioned within the gel template such as to enable drilling into the jaw through the cylinder.

Priority: US20080087707P Applic. Date: 2008-08-10

Inventor: BECK ISRAEL [IL]; BENYAMIN SHABTAY [IL]

Title: Non-90-Degree Ergonomically-Shaped Dental Prophylaxis Angle with a Straight Driving Shaft

Applicant/Assignee:

Application No.: 12/189152   Filing Date: 09/Aug/2008

Abstract:A disposable dental angle with a one-piece hollow housing, having the axis of its head section angled obtusely with respect to the axis of its tail section, is provided. The obtusely angled front aperture of the head section of the housing allows insertion of a driven rotor such that the driven rotor is positioned with an obtuse angle to the driving shaft in the end aperture of the tail section of the housing. The obtuse angle structure facilitates teeth cleaning operations by allowing the dental angle to easily reach all areas of the mouth and making practitioners feel more comfortable by allowing to maintain an ergonomically correct neutral wrist position and therefore reducing hand fatigue. A horseshoe-like snap retainer fits within the head section of the housing over the driven rotor to retain the rotor from coming out. A similar horseshoe-like snap retainer fits within the tail section of the housing over the driving shaft to retain the shaft firmly such that the gear of the driven rotor is always properly coupled to the matching gear of the driving shaft. The driving shaft transfers the rotation from a dental tool to the driven rotor for the purpose of tooth prophy using a cleaning cup.

Priority:

Inventor: WANG DANIEL [US]; SHEN JIANPING [US]; ZHU YONG [CN]

Title: Dental Kit and Method for Retracting Sulcus

Applicant/Assignee: COLTENE WHALEDENT AG

Application No.: 12/535979   Filing Date: 05/Aug/2009

Abstract:Sulcus is retracted from teeth prior to performing a dental procedure on the teeth by applying an expandable curable silicone compound to the surface of the teeth and preventing the silicone compound from expanding in a direction away from the surface of the teeth, thereby forcing the silicone to expand against the sulcus and forcing retraction of the sulcus from contact with the teeth.

Priority: EP20030006052 Applic. Date: 2003-03-19; US2006-546754 Applic. Date: 2006-10-10; WO2003CH00798 Applic. Date: 2003-12-02

Inventor: LUBBERS DIERK [CH]; LAMPL STEPHAN [CH]; KOLLEFRATH RALF [CH]

Title: Machinable Porcelain Compositions and Mill Blanks Thereof

Applicant/Assignee: PENTRON CERAMICS, INC

Application No.: 12/552365   Filing Date: 02/Sep/2009

Abstract:A porcelain blank comprising a porcelain composition for dental restorations comprising a leucite crystallite phase and a glass matrix phase, wherein the leucite crystallites possess diameters not exceeding about 10 micron. Preferably, the porcelain composition has a maturing temperature from about 750 DEG C. to about 1050 DEG C. and a coefficient of thermal expansion from about 9x10-6/ DEG C. to about 17.5x10-6/ DEG C., and comprises: SiO2 57-67 Al2O3 7-15 K2O 7-15 Na2O 6-15 Li2O 0.5-3.

Priority: US1999-460951 Applic. Date: 1999-12-14; US1997-870965 Applic. Date: 1997-06-06; US1996-614044 Applic. Date: 1996-03-12

Inventor: BRODKIN DMITRI G [US]; PANZERA CARLINO [US]; KAISER LISA M [US]

Title: TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS

Applicant/Assignee:

Application No.: 12/488406   Filing Date: 19/Jun/2009

Abstract:A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of JAK kinase activity in a patient are disclosed.

Priority: US20080074510P Applic. Date: 2008-06-20

Inventor: ZHU BING-YAN [US]; SIU MICHAEL [US]; MAGNUSON STEVEN R [US]; PASTOR RICHARD [US]; HAIYING HE [CN]; YISONG XIAO [CN]; JIFU ZHENG [CN]; XING XU [CN]; JUNPING ZHAO [CN]; LIU WENDY [US]

Title: SUBSTITUTED SULFONYLAMINOARYLMETHYL CYCLOPROPANECARBOXAMIDE AS VR1 RECEPTOR ANTAGONISTS

Applicant/Assignee: PFIZER INC

Application No.: 12/578061   Filing Date: 13/Oct/2009

Abstract:This invention provides a compound of the formula (I): wherein A and B are independently CR12 or N

D and E are each independently CR9 or N

R1 represents (C1-C6)alkyl

R2 represents hydrogen, halogen, hydroxy, (C1-C6) alkyl, halo(C1-C6) alkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy or (C1-C6)alkoxy-(C1-C6)alkyl

R3, R4, R5, R6, R10 and R11 each independently represent hydrogen, halogen, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, hydroxy(C1-C6)alkyl or (C1-C6)alkoxy-(C1-C6)alkyl

or R3 and R4 are taken together with the carbon atom to which they are attached to form a 3- to 7-membered carbocyclic ring or heterocyclic ring in which one or two non-adjacent carbon atoms are optionally replaced by an oxygen atom, a sulfur atom or NH

R7 and R9 each independently represent hydrogen, halogen, (C1-C6)alkyl, halo(C1-C6)alkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy, hydroxy(C1-C6)alkoxy, (C1-C6)alkoxy-(C1-C6)alkyl, (C1-C6)alkoxy-(C1-C6)alkoxy, (C1-C6)alkylthio, (C1-C6)alkylsulfinyl, (C1-C6)alkylsulfonyl, NH2, [(C1-C6)alkyl]NH-, [(C1-C6)alkyl]2N-, H2N-(C1-C6)alkoxy, (C1-C6)alkyl-NH-(C1-C6)alkoxy, [(C1-C6)alkyl]2N(C1-C6)alkoxy

H2N-(C1-C6)alkoxy-(C1-C6)alkyl, (C1-C6)alkyl-NH-(C1-C6)alkoxy-(C1-C6)alkyl, [(C1-C6)alkyl]2N(C1-C6)alkoxy-(C1-C6)alkyl or 5- or 6-membered heterocyclic ring containing at least one nitrogen atom

R8 represents halogen, (C1-C6)alkyl, halo(C1-C6)alkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy, hydroxy(C1-C6)alkoxy, (C1-C8)alkoxy-(C1-C6)alkyl, (C1-C6)alkoxy-(C1-C6)alkoxy, halo(C1-C6)alkylsulfonyl, halo(C1-C6)alkylsulfinyl, halo(C1-C6)alkoxy, halo(C1-C6)alkylthio, [(C1-C6)alkyl]NH- or [(C1-C6)alkyl]2N-

or R7 and R8, when E is CR9, are taken together with the carbon atoms to which they are attached form a 5-8 membered carbocyclic or heterocyclic ring, in which one or two non-adjacent carbon atoms are optionally replaced by oxygen, sulfur, N or NH groups, wherein the carbocyclic ring or the heterocyclic ring is unsubstituted or substituted with one or more substituents each independently selected from the group consisting of hydroxy, (C1-C6)alkyl, (C1-C6)alkoxy and hydroxy(C1-C6)alkyl

and R12 represents hydrogen, halogen, (C1-C6)alkyl or hydroxy(C1-C6)alkyl

or a pharmaceutically acceptable salt or solvate thereof. These compounds are useful for the treatment of disease conditions caused by overactivation of VR1 receptor such of pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.

Priority: US2006-384127 Applic. Date: 2006-03-17; US20050733651P Applic. Date: 2005-11-04; US20050699800P Applic. Date: 2005-07-15; US20050663374P Applic. Date: 2005-03-17

Inventor: HANAZAWA TAKESHI [JP]; HIRANO MISATO [JP]; INOUE TADASHI [JP]; NAGAYAMA SATOSHI [JP]; NAKAO KAZUNARI [JP]; SHISHIDO YUJI [JP]; TANAKA HIROTAKA [JP]

Title: COMPOSITIONS CURABLE BY RING OPENING METATHESIS POLYMERIZATION AT LOW TEMPERATURES AND THEIR APPLICATION IN THE DENTAL FIELD

Applicant/Assignee: 3M INNOVATIVE PROPERTIES COMPANY

Application No.: 12/517727   Filing Date: 18/Dec/2007

Abstract:The invention relates to a composition which is polymerizable by ring-opening metathesis polymerization (ROMP) comprising at least one monomer that is polymerizable by ROMP, at least one initiator of the Hoveyda-Grubbs type for initiating the ROMP and at least one retarder selected from the group consisting of heterocyclic a means having a ring with at least one N-atom and four or less other atoms constituting the ring bearing the at least one N-atom. The invention further relates to a process for the preparation of a composition which is polymerizable by ROMP, a dental material obtainable by polymerizing a composition according to the invention and the use of a substance selected from the group consisting of heterocyclic amines having a ring with at least one N-atom and five or less atoms constituting the ring bearing the at least one N-atom or of a mixture of two or more of such substances as a retarder in ROMP.

Priority: EP20060026426 Applic. Date: 2006-12-20; WO2007US87841 Applic. Date: 2007-12-18

Inventor: LUCHTERHANDT THOMAS [DE]; BISSINGER PETER [DE]; HANSEN MIRIAM [DE]

Title: POLYMERIZABLE MONOMER-CONTAINING COMPOSITION

Applicant/Assignee: KURARAY MEDICAL INC

Application No.: 12/523538   Filing Date: 16/Jan/2008

Abstract:The present invention provides a composition suitable for a dental composition. The present invention is a composition containing: a polymerizable monomer (A) having an unconjugated carbon chain with at least four carbon atoms bonded continuously, at least two polymerizable groups, and at least two hydroxyl groups

and a polymerizable monomer (B) having one polymerizable group and at least one hydroxyl group. When a suitable component is added to this composition, the resultant composition can be used suitably for dental materials such as a primer, bonding material, composite resin, and cement.

Priority: JP20070008420 Applic. Date: 2007-01-17; JP20070008421 Applic. Date: 2007-01-17; JP20070073603 Applic. Date: 2007-03-20; WO2008JP50437 Applic. Date: 2008-01-16

Inventor: ISHINO HIROSHIGE [JP]; SEKIGUCHI TAKAHIRO [JP]; OKADA KOICHI [JP]; NISHIGAKI NAOKI [JP]

Title: METHOD OF UTILISING MEASUREMENTS OF THRESHOLD OF PAIN

Applicant/Assignee: ULL METER A/S

Application No.: 12/440438   Filing Date: 10/Sep/2007

Abstract:A method of determining the sympathetic tone and/or level of stress and/or level or warning system sensitivity includes the steps of: measuring an applied stimulation at a threshold value of the stimulation in one or more sympathetic tone-neutral points and measuring an applied stimulation at the same threshold value in one or more sympathetic tone-dependent points. The invention further relates to a system for applying and measuring a stimulation, and the use of a system for applying and measuring a stimulation for determining the sympathetic tone including the steps of: measuring an applied stimulation at a threshold value of the stimulation at one or more sympathetic tone-neutral points and measuring an applied stimulation at the same threshold value of the stimulation at one or more sympathetic tone-dependent points.

Priority: DK20060001159 Applic. Date: 2006-09-08; DK20060001321 Applic. Date: 2006-10-11; DK20070000190 Applic. Date: 2007-02-02; EP20070109765 Applic. Date: 2007-06-06; US20060842984P Applic. Date: 2006-09-08; US20060829068P Applic. Date: 2006-10-11; US20070924986P Applic. Date: 2007-06-07; WO2007EP59471 Applic. Date: 2007-09-10

Inventor: BALLEGAARD SOREN [DK]; MAGNUSSON GISLI [DK]

Title: HOT-MELT COMPOSITION FOR METAL CAN AND METAL CAN UTILIZING THE SAME

Applicant/Assignee: TOYO SEIKAN KAISHA, LTD

Application No.: 12/438053   Filing Date: 20/Aug/2007

Abstract:A hot-melt composition comprising a thermoplastic elastomer, a tackifier, a wax and a polyolefin resin, the wax having a softening point (R & B system) of 140 to 160 DEG C. The hot-melt composition can be easily applied to the mouth-neck portion of a metal can and can be excellently produced. Even when placed under a high-temperature condition, the sealing material that is formed exhibits excellent heat resistance maintaining the sealing.

Priority: JP20060223843 Applic. Date: 2006-08-21; WO2007JP66499 Applic. Date: 2007-08-20

Inventor: ISHIDA KATSUHIKO [JP]; UMANO SETSUO [JP]; UCHIDA KENSAKU [JP]; ISHIGURO HIDEYUKI [JP]; TSURUMAKI SHINOBU [JP]

Title: DISPENSING DEVICE

Applicant/Assignee: SEAQUIST PERFECT DISPENSING GMBH

Application No.: 12/337399   Filing Date: 17/Dec/2008

Abstract:A dispensing device for a cosmetic product is proposed. The dispensing device has a valve with a female valve element. The valve element has at least one engagement section for the positive and/or locking fastening of a male valve adapter which can be inserted into the valve element after assembly of the valve. Moreover, at its sealing side, the valve element forms a wall section which is enlarged in its inner diameter in order to permit faster filling.

Priority: DE200810038673 Applic. Date: 2008-08-12

Inventor: JASPER BERNHARD [DE]

Title: Solid Free-Form Fabrication Methods For The Production Of Dental Restorations

Applicant/Assignee: PENTRON CERAMICS, INC

Application No.: 12/607718   Filing Date: 28/Oct/2009

Abstract:Solid free form fabrication techniques can be utilized indirectly to manufacture substrates, dies, models, near-net shapes, shells, and wax-ups that are then used in the manufacture of dental articles. Digital light processing is the most preferred indirect method for the production of substrates. After the substrates are produced, various coating or deposition techniques such as gel casting, slip casting, slurry casting, pressure infiltration, dipping, colloidal spray deposition or electrophoretic deposition are used to manufacture the dental article.

Priority: US2004-874077 Applic. Date: 2004-06-22; US2001-053430 Applic. Date: 2001-10-22; US2001-946413 Applic. Date: 2001-09-05; US1999-350604 Applic. Date: 1999-07-09; US2001-027017 Applic. Date: 2001-12-18; US1999-376921 Applic. Date: 1999-08-18; US2004-857482 Applic. Date: 2004-05-28; US19980092432P Applic. Date: 1998-07-10; US19980097216P Applic. Date: 1998-08-20; US20030474166P Applic. Date: 2003-05-29

Inventor: BRODKIN DMITRI [US]; PANZERA CARLINO [US]; PRASAD ARUN [US]; DAY GRANT P [US]; BORENSTEIN STEFAN [CA]

Title: Headset With Stowable Boom

Applicant/Assignee: PLANTRONICS, INC

Application No.: 12/190546   Filing Date: 12/Aug/2008

Abstract:A headset comprises a headband for supporting the headset on a user's head, an earpiece including an audio driver and a microphone boom including a microphone. The microphone boom is rotatable when the headset is located on a user's head from an operative position in which the microphone boom is directed towards the user's mouth to a stowed position in which the microphone boom is at least partially received in a recess defined in the headset.

Priority:

Inventor: THOMPSON DALE E [US]; MISTRY MANOJ [US]; LEDINGHAM JOHN B [US]; KRAMER MATTHEW E [US]

Title: EVACUABLE CONTAINER AND EVACUATION STRIP THEREFOR

Applicant/Assignee:

Application No.: 12/190445   Filing Date: 12/Aug/2008

Abstract:An evacuable container comprises a first sidewall that defines an interior of the container and an opening. A flow channel chamber comprises first and second chamber walls. Flow channels are disposed on at least one of the first and second chamber walls. One of the first and second chamber walls is sealingly attached along an entire periphery thereof to the first sidewall. At least one interior aperture is disposed through the first or second chamber wall and is in fluid communication with the interior of the container. At least one exterior aperture is disposed through the first or second chamber wall and is in fluid communication with an exterior of the container. A check valve is disposed in fluid communication with the at least one exterior aperture and the flow channel chamber to allow resealable evacuation of the container through the flow channel chamber and the at least one interior aperture.

Priority:

Inventor: TURVEY ROBERT R [US]

Title: HIGH PENETRATION PRODRUG COMPOSITIONS OF ANTIMICROBIALS AND ANTIMICROBIAL-RELATED COMPOUNDS

Applicant/Assignee:

Application No.: 12/482373   Filing Date: 10/Jun/2009

Abstract:The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of antimicrobials and antimicrobial-related compounds, which are capable of crossing biological barriers with high penetration efficiency. The HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.

Priority: WO2006IB54724 Applic. Date: 2006-12-10

Inventor: YU CHONGXI [US]

Title: NOVEL COMPOSITION

Applicant/Assignee:

Application No.: 12/517675   Filing Date: 06/Dec/2007

Abstract:A post-foaming dentifrice composition having a viscosity of at least 80,000 mPas comprising a combination of a first thickening agent which is xanthan gum, a second thickening agent which is carrageenan and/or a polyacrylic acid and a thickening silica, together with a post-foaming agent to expand the composition to a foam.

Priority: GB20060024578 Applic. Date: 2006-12-08; WO2007EP63480 Applic. Date: 2007-12-06

Inventor: FROST PETER [GB]; MALMSTROM HANNA MARIA [GB]; PENEGAR MARK [GB]; PLATTS ALEXANDER THOMAS [GB]

Title: ACTIVE DELIVERY SYSTEMS FORMULATIONS

Applicant/Assignee: CASTLE BEACH, LLC

Application No.: 12/540201   Filing Date: 12/Aug/2009

Abstract:The present invention relates to active delivery system formulations, and methods of making and using the same. Said formulations, when applied to a substrate surface, form a protective coating on the surface and permit constituent active agents to act on the surface and in the surrounding medium.

Priority: US20080104129P Applic. Date: 2008-10-09; US20080088155P Applic. Date: 2008-08-12

Inventor: HOMOLA ANDREW M [US]; PITTS R GARY [US]; DUNTON RONALD K [US]

Title: Biomimetic Hydroxyapatite Composite Materials and Methods for the Preparation Thereof

Applicant/Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

Application No.: 12/522800   Filing Date: 11/Jan/2008

Abstract:The present invention is related to methods for preparing composite materials, which include nanoscale hydroxyapatite, and the composite materials and articles prepared therewith.

Priority: US2007-622927 Applic. Date: 2007-01-12; US20060758207P Applic. Date: 2006-01-12; WO2008US50940 Applic. Date: 2008-01-11

Inventor: RIMAN RICHARD E [US]; SEVER CHRISTINA [US]

Title: USE OF NITRIC OXIDE

Applicant/Assignee:

Application No.: 12/540335   Filing Date: 12/Aug/2009

Abstract:The present invention relates to uses, compositions, devices, and methods involving the utilisation of nitric oxide to hinder, impede, inhibit, or prevent transmission of infectious viral particles to host cells.

Priority: US20080088656P Applic. Date: 2008-08-13

Inventor: MILLER CHRIS [CA]; MURRAY BRUCE [CA]; REGEV-SHOSHANI GILLY [CA]

Title: CONTROL OF PATHOGENS IN PLANTS, AND AN EFFICIENT MEANS TO ADD NUTRIENTS AND MICRONUTRIENTS TO PLANTS

Applicant/Assignee:

Application No.: 12/193123   Filing Date: 18/Aug/2008

Abstract:This invention consists of a new and novel chemical composition and application method for the control of a number of different types of plant pathogens. A homogeneous aqueous solution is prepared consisting of one or more metallic compounds, a natural product adjuvant for acidifying and forming the complex ions of these metals, and a surfactant. This resulting solution is applied to all plant surfaces down to the soil line until obvious runoff. This application is repeated periodically to totally and completely halt and interrupt the plant pathogen's life cycle in 1-8 weeks during the growing season with more restricted application during the dormant period for prophylactic purposes. This new composition of matter and method of application also serves as a very efficient method to add nutrients and micronutrients to the plant, and to control animal and plant pathogens that reside on a plant host.

Priority:

Inventor: MUSUMECI MICHAEL RICHARD [US]

Title: INHIBITORS OF Akt ACTIVITY

Applicant/Assignee: SMITHKLINE BEECHAM CORPORATION

Application No.: 12/571828   Filing Date: 01/Oct/2009

Abstract:Invented are novel heterocyclic carboxamide compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.

Priority: US2008-027454 Applic. Date: 2008-02-07; US20070888586P Applic. Date: 2007-02-07

Inventor: SEEFELD MARK A [US]; ROUSE MEAGAN B [US]; HEERDING DIRK A [US]

Title: SINGLE-PART, LIGHT-CURABLE, SELF-ADHERING DENTAL RESTORATIVE COMPOSITION AND METHOD OF USING THE SAME

Applicant/Assignee: KERR CORPORATION

Application No.: 12/190762   Filing Date: 13/Aug/2008

Abstract:A dental restorative composition comprising: (A) polymerizable monomer(s) having at least one phosphorus-containing acidic moiety and at least one ethylenically unsaturated group

(B) polymerizable monomer(s) having a molecular weight of 100-250, at least one hydroxyl group, and at least one ethylenically unsaturated group

(C) polymerizable monomer(s) having a molecular weight of 270-900, at least two ethylenically unsaturated groups and no acidic functional group

(D) photo-initiator(s)

and (E) filler(s) each having a mean particle size of more than 0.005 microns and less than 70 microns. The weight ratio of (A+B):(C) ranges from 30:70 to 90:10, the concentration of (A) is 10-50 wt. %, the concentration of (B) is 15-60 wt. %, and the composition has a shear bond strength of at least 10 MPa to both dentin and enamel. Also provided is a method for filling a dental cavity with the composition without first treating the dental cavity with an etchant, a primer and/or an adhesive.

Priority:

Inventor: QIAN XUEJUN [US]

Title: Disposable toothbrush

Applicant/Assignee:

Application No.: 12/484433   Filing Date: 15/Jun/2009

Abstract:A disposable toothbrush includes a handle member produced from a pre-selected biodegradable material. The handle member has a predetermined size and a predetermined shape. There are a predetermined number of rows of bristles attached to and extending above a top surface of the handle member closely adjacent one end thereof. Such bristles have a predetermined length. A pouch containing toothpaste is disposed beneath the rows of bristles such that the toothpaste will be in fluid communication with the bristles when the pouch is punctured and compressed.

Priority: US2008-228986 Applic. Date: 2008-08-19

Inventor: HOLOWECKY BOHDAN [US]

Title: DEVICES AND METHODS FOR MINIMIZING AND TREATING HIGH-ALTITUDE SICKNESS

Applicant/Assignee:

Application No.: 12/541144   Filing Date: 13/Aug/2009

Abstract:Various devices and methods for treating high-altitude sickness are disclosed herein. According to one embodiment, a handheld device delivers a therapeutic amount of nitric oxide to an individual's lungs in order to minimize or treat high-altitude sickness. The device is self-contained and portable, which allows an individual to carry and use the device in high-altitude or other low-oxygen environments.

Priority: US20080090617P Applic. Date: 2008-08-21

Inventor: FINE DAVID H [US]; VASQUEZ GREGORY [US]; JOHNSON BRYAN [US]

Title: Method and Apparatus for Cleaning a Mouthguard

Applicant/Assignee:

Application No.: 12/514920   Filing Date: 14/Nov/2007

Abstract:A device for cleaning and storing a mouthguard, including two main chambers shaped for receiving and holding a mouthguard. One of the main chambers has a sealable lid for retaining disinfecting liquid and the other main chamber has vents to allow water to drain away, and to allow air flow for drying the mouthguard.

Priority: CA20062567905 Applic. Date: 2006-11-14; WO2007CA02012 Applic. Date: 2007-11-14

Inventor: FOGET STEVE [CA]; COGAN DONALD S [CA]

Title: COMPOSTABLE CONTAINER FOR STORING FLUIDS

Applicant/Assignee:

Application No.: 12/544150   Filing Date: 19/Aug/2009

Abstract:A fully compostable container is provided having an enclosed body with an opening through an interior surface and an exterior surface. The enclosed body having a plant fiber structural layer configured to biodegrade in ambient conditions into nontoxic residue and a fluid barrier layer formed on a first side of the structural layer to form the interior surface of the enclosed body, the fluid barrier layer configured to biodegrade in ambient conditions into nontoxic residue. The container is gradually biodegradable when exposed to a set of factors in a natural environment and has a shelf life of six months when stored under standard commercial conditions.

Priority: US20080090871P Applic. Date: 2008-08-21

Inventor: TOLIBAS-SPURLOCK CYNTHIA [US]; ALLRED-FORSMAN BAMBI [US]; AGNEW-VON MOOS DARLA [US]

Title: Method of forming a dental product

Applicant/Assignee:

Application No.: 12/454065   Filing Date: 12/May/2009

Abstract:The invention provides a method of shaping a dental product, comprising: shaping a curable polymerizable composition to form a shape of a dental product. The polymerizable composition is adapted to cure to form polymeric material, which at 37 DEG C. has a flexural modulus of less than 250,000 psi and a flexural strength of less than 7,000 psi.

Priority: US2003-722830 Applic. Date: 2003-11-26

Inventor: SUN BENJAMIN J [US]; LICHKUS ANDREW M [US]

Title: Interaction techniques for flexible displays

Applicant/Assignee:

Application No.: 12/459973   Filing Date: 10/Jul/2009

Abstract:The invention relates to a set of interaction techniques for obtaining input to a computer system based on methods and apparatus for detecting properties of the shape, location and orientation of flexible display surfaces, as determined through manual or gestural interactions of a user with said display surfaces. Such input may be used to alter graphical content and functionality displayed on said surfaces or some other display or computing system. The invention also relates to interactive food or beverage container with associated computing apparatus inside its body, and a curved multitouch display on its surface, associated interaction techniques for curved multitouch displays, methods of use, and apparatus for refilling said electronic food or beverage container.

Priority: US2007-731447 Applic. Date: 2007-03-30; US20060788405P Applic. Date: 2006-03-30

Inventor: VERTEGAAL ROEL [CA]; LEE JUSTIN [CA]; BEHAR YVES [US]; PUTTORNGUL PICHAYA [US]

Title: USES AND METHODS FOR PREVENTING AND/OR TREATING CARIES CAUSED BY MUTANTS STREPTOCOCCI

Applicant/Assignee: BASF SE

Application No.: 12/519451   Filing Date: 18/Dec/2007

Abstract:The present invention relates to the use of a microorganism belonging to the group of lactic acid bacteria or a mutant or derivative thereof, characterized in that it is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci, wherein the specific binding is (i) resistant to heat treatment

and/or (ii) resistant to protease treatment

and/or (iii) calcium-dependent

and/or (iv) formed within a pH range between 4.5 and 8.5

and/or (v) formed in the presence of saliva, for the preparation of an anticariogenic composition for the treatment or prevention of caries caused by mutans Streptococci other than Streptococcus mutans. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase

(b) mixing said microorganism with a bacterium belonging to the group of mutans Streptococci which has been grown to stationary phase

(c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and a bacterium of the group of mutans Streptococci

and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is a method of prophylaxis or treatment of caries caused by mutans Streptococci other than Streptococcus mutans, comprising administering a microorganism belonging to the group of lactic acid bacteria characterized in that said microorganism is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci or a mutant, derivative, analog or fragment of said microorganism.

Priority: EP20060026301 Applic. Date: 2006-12-19; WO2007EP11127 Applic. Date: 2007-12-18

Inventor: REINDL ANDREAS [DE]; LANG CHRISTINE [DE]; BOETTNER MEWES [DE]; VEEN MARKUS [DE]

Title: NOVEL USE

Applicant/Assignee:

Application No.: 12/594502   Filing Date: 03/Apr/2008

Abstract:The use of an oral care composition comprising particulate zinc oxide (suitably in nanoparticulate form) optionally in the presence of a source of fluoride ions is described for combating dental erosion and/or tooth wear. Such compositions are also of use in combating dental caries.

Priority: GB20070006787 Applic. Date: 2007-04-05; WO2008EP54045 Applic. Date: 2008-04-03

Inventor: FOWLER CHRISTABEL [GB]

Title: BASE-MODIFIED RNA FOR INCREASING THE EXPRESSION OF A PROTEIN

Applicant/Assignee: CUREVAC GMBH

Application No.: 12/446912   Filing Date: 31/Oct/2007

Abstract:The present application describes a base-modified RNA and the use thereof for increasing the expression of a protein and for the preparation of a pharmaceutical composition, especially a vaccine, for the treatment of tumours and cancer diseases, heart and circulatory diseases, infectious diseases, autoimmune diseases or monogenetic diseases, for example in gene therapy. The present invention further describes an in vitro transcription method, in vitro methods for increasing the expression of a protein using the base-modified RNA, and an in vivo method.

Priority: DE200610051516 Applic. Date: 2006-10-31; WO2007EP09469 Applic. Date: 2007-10-31

Inventor: HOERR INGMAR [DE]; MULBE FLORIAN VON DER [DE]

Title: NANOCRYSTALS FOR USE IN TOPICAL COSMETIC FORMULATIONS AND METHOD OF PRODUCTION THEREOF

Applicant/Assignee: ABBOTT GMBH & CO. KG

Application No.: 12/514621   Filing Date: 19/Nov/2007

Abstract:Provided are cosmetic preparations for topical application containing nanocrystals of cosmetic actives leading to an increased bioactivity of the molecules in the skin and methods of making the cosmetic preparations. The nanocrystals can be added to any cosmetic topical formulation, e. g. creams, lotions and liposomal dispersions. The drug nanocrystals are produced by a combination process of low energy pearl milling followed by a high energy high-pressure homogenization leading to nanocrystal suspensions (nanosuspensions) of improved physical stability.

Priority: US20060866233P Applic. Date: 2006-11-17; WO2007EP09943 Applic. Date: 2007-11-19

Inventor: PETERSEN ROLF [DE]

Title: UNIFORMLY COLOURED CERAMIC FRAMEWORK AND COLOURING SOLUTION

Applicant/Assignee: 3M ESPE AG (A WHOLLY-OWNED SUBSIDIARY OF 3M COMPANY)

Application No.: 12/610745   Filing Date: 02/Nov/2009

Abstract:The present invention relates to a colouring solution for ceramic framework, the ceramic framework coloured with the solution as well as a process to obtain a uniformly coloured ceramic framework. The solution comprises a solvent, a metal salt and polyethylene glycol having a Mn in the range of 1.000 to 200.000.

Priority: EP20030013513 Applic. Date: 2003-06-13; US2005-560702 Applic. Date: 2005-12-13; WO2004EP06220 Applic. Date: 2004-06-09

Inventor: HAUPTMANN HOLGER [DE]; BISSINGER PETER [DE]

Title: DENTAL RESTORATIONS USING NANOCRYSTALLINE MATERIALS AND METHODS OF MANUFACTURE

Applicant/Assignee: PENTRON CERAMICS, INC

Application No.: 10/857482   Filing Date: 28/May/2004

Abstract:Dental articles are produced using relatively low sintering temperatures to achieve high density dental articles exhibiting strengths equal to and greater than about 700 MPa. Ceramic powders comprised of nanoparticulate crystallites are used to manufacture dental articles. The ceramic powders may include sintering agents, binders and other similar additives to aid in the processing of the ceramic powder into a dental article. The ceramic powders may be processed into dental articles using various methods including, but not limited to, injection molding, gel-casting, slip casting, or electroforming, hand, cad/camming and other various rapid prototyping methods. The ceramic powder may be formed into a suspension, pellet, feedstock material or a pre-sintered blank prior to forming into the dental article.

Priority: US20030474166P Applic. Date: 2003-05-29

Inventor: BRODKIN DMITRI [US]; GAMARNIK MOISEY Y [US]

Title: METHOD OF TREATING OR PREVENTING TISSUE DETERIORATION, INJURY OR DAMAGE DUE TO PERIODONTAL DISEASE OR DISEASE OF ORAL MUCOSA, AND/OR DOWNREGULATING NF-KAPPABETA OR SUPRESSING NF-KAPPABETA-MEDIATED ACTIONS

Applicant/Assignee: REGENERX BIOPHARMACEUTICAL, INC

Application No.: 12/444331   Filing Date: 05/Oct/2007

Abstract:A method of treatment for treating, at least partly preventing, inhibiting or reducing tissue deterioration, injury or damage due to a periodontal disease or disease of oral mucosa, or for restoring tissue adversely affected by the disease, in a subject, and/or for downregulating NF-kappaB or suppressing NF-kappaB mediated action in a body, organ, tissue or cell, includes administering to a subject, body, organ, tissue or cell an effective amount of a composition including a peptide agent including at least one of Thymosin beta 4 (T[beta]4), an isoform of T[beta]4, an N-terminal fragment of T[beta]4, a C-terminal fragment of T[beta]4, T[beta]4 sulfoxide, an LKKTET peptide or conservative variant thereof, an LKKTNT peptide or conservative variant thereof, a KLKKTET peptide or conservative variant thereof, an LKKTETQ peptide or conservative variant thereof, T[beta]4ala, T[beta]9, T[beta]10, T[beta]11, T[beta]12, T[beta]13, T[beta]14, T[beta]15, gelsolin, vitamin D binding protein (DBP), profilin, cofilin, depactin, DnaseI, vilin, fragmin, severin, capping protein, [beta]-actinin, acumentin, an actin-sequestering peptide, an actin binding peptide, an actin-mobilizing peptide, an actin polymerization-modulating peptide, or a stimulating agent that stimulates production of an effective amount of the peptide agent in the subject, body, organ, tissue or cell.

Priority: US20060849841P Applic. Date: 2006-10-06; US20060851992P Applic. Date: 2006-10-17; US20060859521P Applic. Date: 2006-11-17; US20070878701P Applic. Date: 2007-01-05; WO2007US21435 Applic. Date: 2007-10-05

Inventor: SOSNE GABRIEL [US]; WHEATER MICHELLE [US]; GOLDSTEIN ALLAN L [US]

Title: Triazolopyridine JAK Inhibitor Compounds and Methods

Applicant/Assignee:

Application No.: 12/488312   Filing Date: 19/Jun/2009

Abstract:A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of JAK kinase activity in a patient are disclosed.

Priority: US20080074506P Applic. Date: 2008-06-20

Inventor: ZHU BING-YAN [US]; SIU MICHAEL [US]; MAGNUSON STEVEN R [US]; PASTOR RICHARD [US]; HAIYING HE [CN]; YISONG XIAO [CN]; JIFU ZHENG [CN]; XING XU [CN]; JUNPING ZHAO [CN]

Title: Cold Menthol Receptor Antagonists

Applicant/Assignee:

Application No.: 12/539267   Filing Date: 11/Aug/2009

Abstract:Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, L, Q, R1, R2, and R3 are defined herein.

Priority: US20080089928P Applic. Date: 2008-08-19

Inventor: COLBURN RAYMOND W [US]; DAX SCOTT L [US]; FLORES CHRISTOPHER M [US]; LUDOVICI DONALD W [US]; MATTHEWS JAY M [US]; XIA MINGDE [US]; XU XIAOQING [US]; YOUNGMAN MARK A [US]; ZHU BIN [US]

Title: Cold Menthol Receptor Antagonists

Applicant/Assignee:

Application No.: 12/539277   Filing Date: 11/Aug/2009

Abstract:Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein A, L, R1, R2, R4 and R5 are defined herein.

Priority: US20080089933P Applic. Date: 2008-08-19

Inventor: COLBURN RAYMOND W [US]; DAX SCOTT L [US]; FLORES CHRISTOPHER M [US]; LUDOVICI DONALD W [US]; XIA MINGDE [US]; XU XIAOQING [US]; YOUNGMAN MARK A [US]; ZHU BIN [US]

Title: POLYMERIZABLE MONOMER-CONTAINING COMPOSITION

Applicant/Assignee: KURARAY MEDICAL INC

Application No.: 12/523546   Filing Date: 16/Jan/2008

Abstract:The present invention provides a composition suitable for a dental composition. The present invention is a composition containing: a polymerizable monomer (A) having an unconjugated carbon chain with at least four carbon atoms bonded continuously, at least two polymerizable groups, and at least two hydroxyl groups

and a water (B). The composition contains 6 to 2000 parts by weight of the water (B) with respect to 100 parts by weight of the whole amount of polymerizable monomer components. When suitable components are added to this composition, the resultant composition can be used suitably for dental materials such as a primer, bonding material, composite resin, and cement.

Priority: JP20070008420 Applic. Date: 2007-01-17; JP20070008421 Applic. Date: 2007-01-17; JP20070073603 Applic. Date: 2007-03-20; WO2008JP50436 Applic. Date: 2008-01-16

Inventor: ISHINO HIROSHIGE [JP]; SEKIGUCHI TAKAHIRO [JP]; OKADA KOICHI [JP]

Title: COMPOSITION AND DENTAL MATERIAL

Applicant/Assignee: KURARAY MEDICAL INC

Application No.: 12/523591   Filing Date: 16/Jan/2008

Abstract:The present invention provides a composition that exhibits excellent adhesive properties to tooth structure (particularly dentin) when applied as a dental material. The present invention is a composition containing a polymerizable monomer (A) having an unconjugated carbon chain with at least four carbon atoms bonded continuously, at least two polymerizable groups, and at least two hydroxyl groups, and a bisacylphosphine oxide (B) represented by the following formula (1): where the respective symbols are as defined in the specification.

Priority: JP20070008420 Applic. Date: 2007-01-17; JP20070008421 Applic. Date: 2007-01-17; JP20070073603 Applic. Date: 2007-03-20; WO2008JP50439 Applic. Date: 2008-01-16

Inventor: ISHINO HIROSHIGE [JP]; SEKIGUCHI TAKAHIRO [JP]; OKADA KOICHI [JP]; NISHIGAKI NAOKI [JP]; HINAMOTO AI [JP]; SUGIURA MARIKO [JP]

Title: TRACEABILITY PROCESS AND SECURITY ELEMENTS USED IN SAID PROCESS

Applicant/Assignee:

Application No.: 12/312210   Filing Date: 30/Aug/2007

Abstract:Bi-directional cattle traceability process comprising five basic stages: a first document traceability and sanitary certification chain stage, wherein the animals are identified by birth certificates, animal identification attached to the animal's ear and registered in a data centre. A second stage for transfer of animals to another establishment, wherein genetic material is extracted from the offspring not yet weaned, filed and registered and registered in the data centre. A third stage for slaughtering of animals, wherein the slaughtered animal's ear is cut off where the animal identification is attached and the animal identification is read on line, the half carcases have sealed strips applied to them, DNA samples are extracted from the animal, then deposited in the official genetic bank and on each cut a locket sampler is attached encrypting a genetic and biochemical sample. A fourth stage for transfer or exporting of cuts, wherein the barcode that originated the cut is identified and applied to each portion of this cut or piece into which it is divided and then the locket sampler is removed from each sliced or minced cut, to deposit it in the cold storage chamber. A fifth and last stage of traceability auditing, wherein three samples of the identified portion of a cut to de audited are taken and adulteration of the cut or non-adulteration is determined by comparing the genetic sample taken in the third stage with the encrypted genetic sample in the locket sampler that held the original cutting extracted in the fourth stage. Alternative traceability processes addressed to fishing and canning and a set of elements used in the different stages of the three processes are also disclosed.

Priority: AR2006P104750 Applic. Date: 2006-10-30; WO2007BR00297 Applic. Date: 2007-08-30

Inventor: LIMA ALBERTO JULIO MINORINI [AR]

Title: Suction nozzle for a vacuum cleaner

Applicant/Assignee:

Application No.: 12/231643   Filing Date: 04/Sep/2008

Abstract:A suction nozzle for a vacuum cleaner has a housing, a vacuum mouth disposed on the floor side in the housing, a cleaning roller mounted to rotate in the housing and driven by an electric motor, and a rechargeable battery unit for the energy supply of the electric motor. Via a rear connecting piece, the suction nozzle can be connected to a suction tube or a suction hose of a vacuum cleaner. The electric motor has a rated power of between 50 and watts, and the rechargeable battery unit has an energy density, relative to its total volume, of more than 200 watt-hours per liter (Wh/L).

Priority:

Inventor: KAFFENBERGER DIETER [DE]; DILGER HORST [DE]; RIEHL KLAUS-DIETER [DE]

Title: AIR CONDITIONER

Applicant/Assignee:

Application No.: 12/529278   Filing Date: 20/Feb/2008

Abstract:A centrifugal fan mounted in an air conditioner has the following relationship: outer diameter of a side plate of the centrifugal fan>outer diameter of the blade rear-edge part on side-plate side>diameter of the blade rear-edge part on main plate side>outer diameter of the main plate. In the centrifugal fan, the blade rear-edge part is positioned inside from a straight line connecting the connection point between the blade rear-edge part and the main plate, to the connection point between the blade rear-edge part and the side plate, as viewed from the rotation axis. The blade rear-edge part has a shape such that the distance from the rotation axis becomes larger from the main plate toward the side plate.

Priority: JP20070065337 Applic. Date: 2007-03-14; WO2008JP52797 Applic. Date: 2008-02-20

Inventor: IKEDA TAKASHI [JP]; TAKAHARA NAHO [JP]; TSUTSUMI HIROSHI [JP]; YAMATANI TAKAHIRO [JP]; NISHIMIYA KAZUNOBU [JP]; KAWANORI YUKIHIKO [JP]

Title: Toothbrush combined with rinsing cup

Applicant/Assignee:

Application No.: 12/202202   Filing Date: 29/Aug/2008

Abstract:The technology described herein provides a combined toothbrush and rinsing cup. A combined toothbrush and rinsing cup includes a head, a plurality of bristles disposed upon the head, a body integrally connected to the head, a connectivity base integrally connected to the body, and a male connector integrally connected to the connectivity base. Additionally, a combined toothbrush and rinsing cup includes a toothbrush handle connected to the toothbrush, the toothbrush handle that includes a connector end, a female connector disposed within the connector end of the toothbrush handle and configured for sealable attachment to the male connector of the toothbrush, and a hollow cavity disposed within the toothbrush handle and configured for use as a rinsing cup. The toothbrush is removably connected to the toothbrush handle and wherein the toothbrush is configured for inversion and subsequent storage within the toothbrush handle.

Priority:

Inventor: DJANG SAM S [US]

Title: MALODOUR COUNTERACTING COMPOSITION

Applicant/Assignee:

Application No.: 12/517188   Filing Date: 07/Dec/2007

Abstract:A composition for counteracting malodour due to thiols, with the composition including a polyphenol, a source of polyphenol, a composition comprising polyphenol or mixtures thereof, a base, and optionally, an enzyme, wherein the polyphenol is encapsulated. The polyhenol is preferably a green tea extract and the enzyme is polyphenol (per)oxidase acetone powder.

Priority: US20060871259P Applic. Date: 2006-12-21; WO2007IB54963 Applic. Date: 2007-12-07

Inventor: DOUGHERTY KENNETH PAUL [US]; PIKA JANA [US]; ZENG QIAOLING CHARLENE [US]

Title: COMBINATIONS FOR ORAL COMPOSITIONS, THEIR PREPARATION AND USE

Applicant/Assignee: ORALDENT LIMITIED

Application No.: 12/374443   Filing Date: 20/Jul/2007

Abstract:A composition having a pH in the range of from 3 to 8.5, comprising: (a) in the range of from 0.1% to <10% w/w (based on the total weight of the composition) of a stock solution comprising a mixture of bioflavonoids and fruit acids or salts thereof

(b) sodium hyaluronate

and (c) water

and, optionally, (d) a pharmaceutically acceptable carrier therefor

wherein the sodium hyaluronate has an average molecular weight of between 800,000 and 4,000,000.

Priority: GB20060014353 Applic. Date: 2006-07-20; WO2007GB02756 Applic. Date: 2007-07-20

Inventor: RIPLEY IAN [GB]; THOMAS HOWARD [GB]

Title: HYDROGEL FACE MASK FOR DELIVERING SKIN CARE AGENTS

Applicant/Assignee:

Application No.: 12/199751   Filing Date: 27/Aug/2008

Abstract:Skin care can be provided by the skin care devices and compositions described herein. Such a skin care device can be configured to include a biocompatible hydrogel layer including one or more treatment agents, and an associated backing layer associated with the hydrogel layer.

Priority:

Inventor: AHN DONG JUNE [KR]

Title: DENTAL TREATMENT TRAYS COMPRISING SILICONE OR OTHER ELASTOMERIC MATERIAL

Applicant/Assignee: ULTRADENT PRODUCTS, INC

Application No.: 12/201902   Filing Date: 29/Aug/2008

Abstract:Non-customized dental treatment trays used to provide a desired treatment are formed from elastomeric silicone or silicone-like material. They may be injection molded from a two-part liquid silicone composition or a silicone-like TPE material (e.g., preferably SEBS and/or VERSAflex thermoplastic elastomer). The dental treatment trays possess high adaptability, flexibility, softness, and elastic elongation while also exhibiting resiliency in order to readily conform to the ridges, depressions and contours of a person's teeth during use. The trays possess a greater ability to adhere to a person's teeth compared to non-elastomeric thermoplastic materials. Due to their high adaptability and conformability, the non-customized dental trays behave like a semi-custom dental tray when placed over conformed to a person's teeth, particularly when used in combination with a sticky, viscous treatment composition.

Priority:

Inventor: LEWIS PAUL [US]; ANDERSEN SCOT N [US]; ALLRED PETER M [US]; FISCHER DAN E [US]

Title: CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS

Applicant/Assignee: NEUROSEARCH A/S

Application No.: 12/615925   Filing Date: 10/Nov/2009

Abstract:This invention relates to novel chromen-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

Priority: DK20040001491 Applic. Date: 2004-09-30; US2007-661966 Applic. Date: 2007-03-06; WO2005EP54861 Applic. Date: 2005-09-28; US20040614052P Applic. Date: 2004-09-30

Inventor: PETERS DAN [SE]; OLSEN GUNNAR M [DK]; SCHEEL-KRUGER JORGEN [DK]; NIELSEN ELSEBET OSTERGAARD [DK]

Title: Preservative compositions

Applicant/Assignee:

Application No.: 12/589155   Filing Date: 19/Oct/2009

Abstract:Green and naturally derived biocides such as N[alpha]-(C1-C22) alkanoyl di basic amino acid alkyl (C1 to C22) ester salt cationic molecules can be combined with an anionic molecule not generally considered as having significant biocidal activity to provide antimicrobial, antibacterial, and/or antifungal properties with multifunctional benefits including preservative or self-preserving activity.

Priority: US2006-517147 Applic. Date: 2006-09-07; US2006-633231 Applic. Date: 2006-12-04; US2009-585695 Applic. Date: 2009-09-22; US2009-583919 Applic. Date: 2009-08-27; US20080196455P Applic. Date: 2008-10-17

Inventor: STOCKEL RICHARD F [US]; SAWYER ANTHONY JOSEPH [US]

Title: N-Substituted-P-Menthane-3-Carboxamide and Uses Thereof

Applicant/Assignee:

Application No.: 12/519801   Filing Date: 30/Nov/2007

Abstract:The present invention relates to substances and compositions having a physiological cooling effect on the skin and the mucosa of the body, especially of the oral cavity, throat and nose. More in particular, the present invention relates to N-substituted-p-menthane-3-carboxamides represented by the following formula (I): and esters thereof. These substances are capable of imparting and/or enhancing a physiological cooling effect in a product in which they are incorporated, much more effectively than the heretofore known N-substituted-p-menthane-3-carboxamides.

Priority: EP20060126622 Applic. Date: 2006-12-20; US20070982464P Applic. Date: 2007-10-25; WO2007NL50609 Applic. Date: 2007-11-30

Inventor: FURRER STEFAN MICHAEL [US]; TONDEUR SANDER [NL]; WINKEL CHRIS [NL]; RENES HARRY [NL]; DE KLERK ADRI [NL]

Title: POLYMERIZABLE MONOMER, POLYMERIZABLE COMPOSITION AND DENTAL MATERIAL

Applicant/Assignee: KURARAY MEDICAL INC

Application No.: 12/532289   Filing Date: 06/Mar/2008

Abstract:The present invention provides a polymerizable composition that imparts excellent adhesive properties with respect to tooth structure (particularly dentin) when applied as a dental material, and provides a polymerizable monomer that is used as a component of the polymerizable composition. The present invention is a compound (A) that is a compound represented by the following formula (1): where G indicates a polymerizable group, m indicates an integer of 2 or more, n indicates an integer of 1 or more, and the sequence order of m units having a polymerizable group and n units having a hydroxyl group is arbitrary. The present invention also is a polymerizable composition containing the compound (A).

Priority: JP20070073603 Applic. Date: 2007-03-20; WO2008JP54087 Applic. Date: 2008-03-06

Inventor: SEKIGUCHI TAKAHIRO [JP]

Title: DEVICE SURFACE DESIGN FOR BETTER CELL ADHESION

Applicant/Assignee:

Application No.: 12/201855   Filing Date: 29/Aug/2008

Abstract:Embodiments herein relate to devices promoting cell adhesion and methods of making thereof In some embodiments, one or more insoluble or non-degradable second surface components are positioned over one or more soluble or degradable first surface components over a surface. The first surface components can be degraded or dissolved to produce bumps or raised portions formed from the second surface components on the surface.

Priority:

Inventor: LEE KWANGYEOL [KR]

Title: PORTABLE URINAL

Applicant/Assignee:

Application No.: 12/207547   Filing Date: 10/Sep/2008

Abstract:Embodiments provide portable apparatus adapted to accommodate a plurality of persons standing to engage in acts of urination, the portable apparatus including a movable base having a base outer edge, a movable base upper portion having a raised base central portion spaced in an inward direction from the base outer edge, a movable base upper portion including a plurality of spaced floor subsections intermediate a vertical riser and the base outer edge, the movable base upper portion including intermediate the plurality of spaced floor subsections a plurality of raised lower interior privacy partitions, each of said lower interior privacy partitions defining a secondary vertical riser, each of the raised lower interior privacy partitions adjoining a raised base central portion such that each secondary vertical riser cooperates with the vertical riser to define raised upper portions of a tank compartment, the tank compartment being defined by an interior space of the movable base.

Priority:

Inventor: BOURGEOIS BRYAN J [US]; BEARD GUY MICHAEL [US]

Title: Compositions and Methods for Modulating Store-Operated Calcium Entry

Applicant/Assignee:

Application No.: 12/279871   Filing Date: 20/Mar/2007

Abstract:Compositions and methods for modulating activity of store-operated calcium entry in cells or tissues are provided. The compositions comprise the P311 protein, fused to a cell-penetrating peptide and formulated for delivery to tissues and cells. This protein has been shown to increase the levels of store-operated calcium entry (SOCE) in gingival cells, skeletal muscle cells, and prostate epithelial cells. Also provided are methods for preventing and treating diseases that involve administration of the P311 fusion protein, as well as methods for increasing levels of SOCE in cells.

Priority: US20060783999P Applic. Date: 2006-03-20; WO2007US64365 Applic. Date: 2007-03-20

Inventor: MA JIANGIE [US]; WEISLEDER NOAH [US]; PAN ZUI [US]

Title: ORAL HEALTH COMPOSITION COMPRISING ALCHEMILLA VULGARIS

Applicant/Assignee: MARS INCORPORATED

Application No.: 12/517342   Filing Date: 27/Nov/2007

Abstract:The present invention relates to Alchemilla vulgaris for use in oral health applications, an oral composition comprising Alchemilla vulgaris, and the use of Alchemilla vulgaris or the composition, in the improvement or maintenance of oral health in an animal, preferably through the reduction or control of dental plaque and/or alteration of the bacterial content of dental plaque, in the oral cavity of the animal. The invention also includes Alchemilla vulgaris for use in the prevention or treatment of gingivitis in an animal. The invention also provides a method for improving or maintaining oral health in an animal

Priority: GB20060025429 Applic. Date: 2006-12-20; WO2007GB04522 Applic. Date: 2007-11-27

Inventor: MARSHALL-JONES ZOE [GB]; BAILLON MARIE-LOUISE [GB]; BUCKLEY CATHERINE [GB]

Title: ORAL HYGIENE COMPOSITION COMPRISING MYRTLE

Applicant/Assignee: MARS INCORPORATED

Application No.: 12/516280   Filing Date: 27/Nov/2007

Abstract:The present invention relates to myrtle for use in oral health applications, an oral composition comprising myrtle, and the use of myrtle or the composition, in the improvement or maintenance of oral health in an animal, preferably through the reduction or control of dental plaque and/or alteration of the bacterial content of dental plaque, in the oral cavity of the animal. The invention also includes myrtle for use in the prevention or treatment of gingivitis in an animal. The invention also provides a method for improving or maintaining oral health in an animal.

Priority: GB20060023619 Applic. Date: 2006-11-27; WO2007GB04532 Applic. Date: 2007-11-27

Inventor: MARSHALL-JONES ZOE [GB]; BAILLON MARIE-LOUISE [GB]; BUCKLEY CATHERINE [GB]

Title: Method for Treating Human Diseases Associated With an Increased Deoxyribonucleic Acid Content in Extracellular Spaces of Tissues and a Medicinal Preparation for Carrying Out Said Method

Applicant/Assignee:

Application No.: 12/516440   Filing Date: 28/Nov/2006

Abstract:The invention relates to medicine. The inventive method for treating human diseases associated with an increased deoxyribonucleic acid content in extracellular spaces of tissues and organs, consists in orally injecting a DNA ferment in a quantity of 20 000-500 000 Kunz units in a day per 1 kg of the body mass. The single dose of the inventive medicinal preparation for treating human diseases associated with an increased deoxyribonucleic acid content in extracellular spaces of tissues and organs comprises 20 000-500 000 Kunz units of the DNAse ferment. The oral administration of the above-mentioned important doses of the preparation only allows the catalytically significant amount of DNAse to be absorbed into the systemic circulation in such a way that the dose-dependent treating effect thereof is exhibited.

Priority: WO2006RU00642 Applic. Date: 2006-11-28

Inventor: GENKIN DMITRY DMITRIEVICH [RU]; TETS VIKTOR VENIAMINOVICH [RU]; TETS GEORGY VIKTOROVICH [RU]

Title: USE OF DIACETYL DIMER AS AN AROMATIC AND/OR FLAVOURING SUBSTANCE

Applicant/Assignee: SYMRISE GMBH & CO., KG

Application No.: 12/300820   Filing Date: 07/May/2007

Abstract:The invention relates to the use of 5-acetyl-2,5-dimethyl-2-hydroxy-tetrahydrofuran-3-one (diacetyl dimer of formula (I)) in the form of one of its stereoisomers or in the form of a mixture consisting of or containing two, three or four of its stereoisomers (i) for imparting, intensifying and/or modifying a creamy and/or fatty sensation in the mouth, (ii) for imparting, intensifying and/or modifying a sweet, buttery, cream-like and/or creamy flavour

and/or (iii) as an aromatic and/or flavouring substance. The invention furthermore relates to a process (i) for imparting, intensifying and/or modifying a creamy and/or fatty sensation in the mouth, (ii) for imparting, intensifying and/or modifying a sweet, buttery, cream-like and/or creamy flavour, to corresponding aromatic compositions, to formulations selected from a nutrition formulation (foodstuff), an oral hygiene formulation, a luxury product formulation, a formulation for oral pharmaceutical use or a semi-finished good formulation for the preparation of nutrition formulations or luxury product formulations, as well as preparations comprising one or more of said compositions and/or formulations.

Priority: US20060803715P Applic. Date: 2006-06-02; WO2007EP54401 Applic. Date: 2007-05-07

Inventor: LEY JAKOB [DE]; WEBER BERTHOLD [DE]; KRAMMER GERHARD [DE]; REISS INGO [DE]; BERTRAM HEINZ-JUERGEN [DE]; GALFIELD IAN [DE]; HOFFMANN-LUECKE PETRA [DE]

Title: PEPTIDE-BASED COMPOUNDS AS NEW INHIBITORS OF METALLOECTOPEPTIDASES, COMPOSITIONS COMPRISING SAID COMPOUNDS AND THEIR PHARMACEUTICAL AND COSMETIC USES

Applicant/Assignee: GREENPHARMA

Application No.: 12/524955   Filing Date: 04/Feb/2008

Abstract:The invention relates to a compound that inhibits a metallo-ectopeptidase, selected in the group consisting of x-aa2-aa1-z, x-aa3-aa2-aa1-z, x-aa4-aa3-aa2-aa1-z and x-aa5-aa4-aa3-aa2-aa1-z, wherein: aa1 and aa4, independently from each other, represent an arginine amino acid, an histidine amino acid, an asparagine amino acid or a lysine amino acid, aa2 represents a serine amino acid, a glycine amino acid, a threonine amino acid or an alanine amino acid, aa3 represents a phenylalanine amino acid, a leucine amino acid, an isoleucine amino acid, a tyrosine amino acid or a tryptophan amino acid, aa5 represents a glutamine amino acid, a glutamic acid amino acid, an asparagines amino-acid or a lysine amino acid, x and z, independently from each other, represent: -H

-OH1 SH

-a halogen atom, -an amino group, -an alkyl, haloalkyl or heteroalkyl group containing from 1 to 30 carbon atoms, linear or branched, -an alkenyl or alkynyl group containing from 2 to 30 carbon atoms, linear or branched, -a cycloalkyl, cycloakenyl, cycloalkynyl or an heterocyclic group containing from 3 to 30 carbon atoms, linear or branched, -one or more aryl or heteroaryl groups containing from 3 to 10 carbon atoms per cycle, -a alkoxy, thioalkyl, sulfonylalkyl, aminoalkyl containing from 1 to 30 carbon atoms, linear or branched, -one or more heterocyclic group, containing from 5 to 10 carbon atoms per cycle, said groups being optionally substituted by one or more halogen atoms, alkyl groups, hydroxy groups, alkoxy groups, aryloxy groups, acyloxy groups, carbamoyloxy groups, carboxy groups, mercapto groups, alkylthio groups, acylthio groups, arylthio groups, aryl groups, heterocyclic groups, heteroaryl groups or amino groups.

Priority: US20070899033P Applic. Date: 2007-02-02; WO2008IB01328 Applic. Date: 2008-02-04

Inventor: BERNARD PHILIPPE [FR]

Title: Compositions and Methods of Their Use for Improving the Condition and Appearance of Skin

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 12/621027   Filing Date: 18/Nov/2009

Abstract:The present invention relates to compositions and methods for treating, preventing and improving the condition and aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, where the compositions include natural plant constituents, or synthetic equivalents thereof, which inhibit or decrease expression of C-reactive protein expression, production or secretion, thereby reducing, inhibiting, or ameliorating dermatological signs of aging. The compositions of the invention may be topically applied to the skin, or are delivered by directed means to a site in need thereof, in an amount effective in improving the condition and aesthetic appearance of skin.

Priority: US2006-647648 Applic. Date: 2006-12-29

Inventor: DRYER LAURENCE [US]; TAFURI SHERRIE R [US]; PTCHELINTSEV DMITRI S [US]

Title: PREFORMED MALLEABLE MULTILAYER DENTAL ARTICLES

Applicant/Assignee:

Application No.: 12/440615   Filing Date: 12/Sep/2007

Abstract:A dental article includes an external layer formed of a self-supporting hardenable preformed material having a dental article shape defined by an external layer surface. The external layer defines an interior volume. An interior material is disposed within the interior volume. The interior material is different than the external hardenable preformed material and the interior material has a yield stress value of 100 dyn/cm2 or greater.

Priority: US20060825496P Applic. Date: 2006-09-13; WO2007US78235 Applic. Date: 2007-09-12

Inventor: JONES TODD D [US]; KARIM NAIMUL [US]; JACOBS DWIGHT W [US]

Title: DENTAL CLEANING DEVICE

Applicant/Assignee: RYCA INTERNATIONAL, INC

Application No.: 12/555662   Filing Date: 08/Sep/2009

Abstract:Powered toothbrush systems that provide improved bristle positioning and bristle contact with tooth surfaces that reduce the time and effort required for effective brushing. Some embodiments use alternating or oscillating pneumatic pressure and suction to move a tooth brush head. Various configuration of the brush head provide different areas of coverage ranging from individual tooth to quarter mouth (U-cross section), to half (U-cross section or H-cross section) or whole mouth (U-cross section or H-cross section) coverage. Some embodiments include flexible fingers and/or bladders to keep the bristle tips properly engaged with the teeth and gums, providing bristle contact over a wide variety of malocclusion. The shape of the brush heads adapts to conform closely to the shape of the user's dental arch and to any malocclusion that may be present. The power toothbrush automatically generates motion of the brush head that simulates the "Modified Bass Method" of brushing.

Priority: US20080095219P Applic. Date: 2008-09-08

Inventor: BREWER GERALD K [US]

Title: DISPENSER TIP FILTER ASSEMBLY

Applicant/Assignee:

Application No.: 12/594606   Filing Date: 21/Apr/2008

Abstract:The invention features a dispenser tip filter assembly for dispensing fluid compositions, especially dental compositions, containing solid particles. The assembly includes a dispenser tip comprising a filter housing chamber and an exit orifice, and a filter unit positioned within the filter housing chamber in front of the exit orifice. The filter unit has one or more slots with a width less than the diameter of the exit orifice.

Priority: US20070913387P Applic. Date: 2007-04-23; WO2008US60990 Applic. Date: 2008-04-21

Inventor: CERNOHOUS ADAM J [US]

Title: C-MET MUTATIONS AND USES THEREOF

Applicant/Assignee:

Application No.: 12/530172   Filing Date: 14/Mar/2008

Abstract:The present invention relates generally to the fields of molecular biology and growth factor regulation. More specifically, the invention concerns methods and compositions useful for diagnosing and treating human lung cancer associated with mutated c-Met.

Priority: US20070918254P Applic. Date: 2007-03-15; WO2008US57075 Applic. Date: 2008-03-14

Inventor: SALGIA RAVI [IL]

Title: Modulators of muscarinic receptors

Applicant/Assignee: VERTEX PHARMACEUTICALS INCORPORATED

Application No.: 11/894092   Filing Date: 20/Aug/2007

Abstract:The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

Priority: US20060838701P Applic. Date: 2006-08-18

Inventor: DAVIES ROBERT J [US]; XU JINGWANG [US]

Title: FOOD COMPOSITION FOR BINDING ACETALDEHYDE IN MOUTH AND IN DIGESTIVE TRACK, AND METHOD FOR THE PREPARATION OF THE COMPOSITION

Applicant/Assignee: BIOHIT OYJ

Application No.: 12/622145   Filing Date: 19/Nov/2009

Abstract:The object of the invention comprises food compositions, to which one or more acetaldehyde-binding compounds are added. The purpose of the compositions is to reduce the amount of detrimental acetaldehyde in the area of the mouth, the pharynx, the oesophagus, the stomach, and the small and large intestines, and through this, to reduce the risk of developing cancers in these areas.

Priority: FI20050000341 Applic. Date: 2005-04-01; US2007-910458 Applic. Date: 2007-10-01; WO2006FI00104 Applic. Date: 2006-04-03

Inventor: SUOVANIEMI OSMO [FI]; SALASPURO MIKKO [FI]; SALASPURO VILLE [FI]; MARVOLA MARTTI [FI]

Title: COMPOSITIONS CONTAINING PHOSPHONATE-FUNCTIONAL PARTICLES

Applicant/Assignee: WACKER CHEMIE AG

Application No.: 12/513607   Filing Date: 22/Oct/2007

Abstract:Phosphonatoalkylsilyl-functional particles have high stability and resistance to agglomeration. When used in curable binder compositions, the particles contribute to a high level of scratch resistance.

Priority: DE200610053156 Applic. Date: 2006-11-10; WO2007EP61257 Applic. Date: 2007-10-22

Inventor: BRIEHN CHRISTOPH [DE]; BAUMANN MARTINA [DE]; JUNG-ROSSETTI SILVIA [DE]; STANJEK VOLKER [DE]

Title: DEVICE FOR THE ORAL APPLICATION OF A SUBSTANCE

Applicant/Assignee: SANDOZ AG

Application No.: 12/595739   Filing Date: 10/Apr/2008

Abstract:A device for oral application of a substance, comprising an inner tube surrounding a first volume an outer tube surrounding a second volume, the second volume comprising a cavity section adjoining an inlet opening of the outer tube being adapted for containing the substance, a separation area arranged in the second volume, the separation area adjoining the cavity section and the first volume, and a selective connecting passage between the cavity section and a pressure compensation space to selectively enable a flow of the substance from the cavity section though the first volume. A kit-of-parts, comprises the inventive device a predefined amount of a substance being contained in a receptacle or the cavity section, and instructions for the use of the substance. Methods for filling the inventive device as well as to a method for oral application using the inventive device are provided.

Priority: EP20070105845 Applic. Date: 2007-04-10; DE200710031368 Applic. Date: 2007-07-05; WO2008EP02820 Applic. Date: 2008-04-10

Inventor: SCHWARZ FRANZ XAVER [AT]; JAKOB THOMAS [DE]; REICHENBERGER ROBERT [DE]

Title: NOSE CLEANER, AND NOSE AND TOOTH CLEANER

Applicant/Assignee:

Application No.: 12/211222   Filing Date: 16/Sep/2008

Abstract:The invention relates to a nose cleaner in removing booger to make nasal vestibule clean, no matter a nose cleaner alone or a nose and tooth cleaner. A nose cleaner alone has a handle and a nose cleaning body. The nose cleaning body can be put into a nostril in removing booger to make nasal vestibule clean. On the other hand, a nose and tooth cleaner has a handle, a tooth cleaning body, and a nose cleaning body. It is convenient that besides of cleaning teeth with the tooth cleaning body, the nose cleaning body is availed to a user in putting into a nostril and removing booger to make nasal vestibule clean.

Priority:

Inventor: LEE CHUN YI [TW]

Title: Method for Preparing Fuel Element For Smoking Article

Applicant/Assignee: R.J. REYNOLDDS TOBACCO COMPANY

Application No.: 12/233192   Filing Date: 18/Sep/2008

Abstract:The invention provides a method for making a fuel element for a smoking article comprising forming a combustible carbonaceous material into a fuel element adapted for use in a smoking article

incorporating a metal-containing catalyst precursor into the fuel element or onto the surface thereof to form a treated fuel element, the incorporating step occurring before, during, or after said forming step

and optionally heating or irradiating the treated fuel element at a temperature and for a time sufficient to convert the catalyst precursor to a catalytic metal compound. Examples of metal-containing catalyst precursors include iron nitrate, copper nitrate, cerium nitrate, cerium ammonium nitrate, manganese nitrate, magnesium nitrate, and zinc nitrate. Fuel elements treated according to the invention, and smoking articles including such fuel elements, are also provided.

Priority:

Inventor: BANERJEE CHANDRA KUMAR [US]; SEARS STEPHEN BENSON [US]

Title: Methods of Making Orthodontic Appliances

Applicant/Assignee:

Application No.: 12/620826   Filing Date: 18/Nov/2009

Abstract:Methods of making a removable dental positioning appliance include forming a sheet of transparent crystalline polymeric material into a shell having cavities shaped to receive and reposition teeth from a first orientation to a successive orientation. The polymeric material may then be annealed at a temperature above its glass transition temperature or cured if a curable material to enhance characteristics of the polymeric material. The polymeric material may be coated with a second transparent material.

Priority: US2004-963252 Applic. Date: 2004-10-12

Inventor: DESIMONE JOSEPH M [US]; TRICCA ROBERT E [US]

Title: ORAL COMPOSITIONS, THEIR PREPARATION AND USE

Applicant/Assignee: ORAIDENT LIMITED

Application No.: 12/374447   Filing Date: 20/Jul/2007

Abstract:An oral composition having a pH in the range of from 3 to 8.5, comprising: (a) in the range of from 0.1% to <10% w/w (based on the total weight of the oral composition) of a stock solution comprising a mixture of bioflavonoids and fruit acids or salts thereof

and (b) water

and, optionally, (c) a pharmaceutically acceptable carrier therefor.

Priority: GB20060014353 Applic. Date: 2006-07-20; WO2007GB02758 Applic. Date: 2007-07-20

Inventor: RIPLEY IAN [GB]

Title: Cleansing Composition

Applicant/Assignee:

Application No.: 12/158918   Filing Date: 29/Dec/2006

Abstract:The present invention relates to a cleansing composition comprising an anti-microbial agent and a sulphur binding and/or oxidising agent, and wherein the pH of the composition is 7 or lower, to a method for preparing the cleansing composition and its use.

Priority: EP20050078067 Applic. Date: 2005-12-30; WO2006EP12656 Applic. Date: 2006-12-29

Inventor: LAUGEMAN FRITS JAN RUDOLF [NL]

Title: FUNCTIONALIZED CALCIUM PHOSPHATE HYBRID SYSTEMS FOR CONFECTIONERY AND FOODSTUFF APPLICATIONS

Applicant/Assignee:

Application No.: 12/210137   Filing Date: 12/Sep/2008

Abstract:A method of whitening teeth, including an application of functionalized calcium phosphate additives generated via a solid-state method. The additives were produced by placing predetermined amounts of inorganic and inorganic materials and milling media into a vessel rotatably connected to a turntable platform, an amount of an organic material into the vessel, rotating the vessel in a first direction while turning the turntable platform in a second direction counter to the first direction, with the resultant material defining the functionalized calcium phosphate. The inorganic material may include calcium phosphates of varying phases, structure, and composition. The organic material may include anionic surfactants, cationic surfactants, neutral surfactants, carboxylic acids, polymers, copolymers, block copolymers, and combinations thereof. Once produced, the additives were added to comestibles, such as in confectionery and foodstuff formats, for delivery to the teeth and dental structures.

Priority:

Inventor: KARLINSEY ROBERT L [US]

Title: NATURAL PRODUCT INHIBITORS OF 3DG

Applicant/Assignee:

Application No.: 12/474904   Filing Date: 29/May/2009

Abstract:Compositions are disclosed which have as a component thereof an inhibitor of the enzymatic production of 3-deoxyglucosone (3DG) from fructoselysine and/or an inactivator of 3DG, and which are useful for the treatment or prophylaxis of a condition or disease state that is alleviated by inhibiting such 3DG production. Methods of using such compositions, e.g., for improving the appearance, texture and/or elasticity of aging skin, are also disclosed.

Priority: US20080057398P Applic. Date: 2008-05-30

Inventor: TOBIA ANNETTE [US]; ALICE MARCY [US]; SU BANGYING [US]; NIWA TAKESHI [JP]

Title: Novel Phosphorus-calcium-strontium compound and uses thereof in endodontic cements

Applicant/Assignee:

Application No.: 12/373225   Filing Date: 09/Jul/2007

Abstract:Phosphorus-calcium-strontium compound of formula (I)

method for preparing same

composition for the extemporaneous preparation of a cement comprising a solid phase (SP) and a liquid phase (LP), wherein the solid phase comprises a mixture of inorganic compounds of formula (II)

use as an endodontic cement.

Priority: FR20060006372 Applic. Date: 2006-07-12; WO2007FR01176 Applic. Date: 2007-07-09

Inventor: BOUDEVILLE PHILIPPE [US]

Title: PHARMACEUTICAL COMPOSITIONS OF AN SRC KINASE INHIBITOR AND AN AROMATASE INHIBITOR

Applicant/Assignee: WYETH

Application No.: 12/557668   Filing Date: 11/Sep/2009

Abstract:This invention is directed to a pharmaceutical composition comprising an Src kinase inhibitor and an aromatase inhibitor, and to the use of a combination of an Src kinase inhibitor and an aromatase inhibitor in treating abnormal cell proliferation and abnormal angiogenesis associated with cancer, including breast cancer.

Priority: US20080096155P Applic. Date: 2008-09-11; US20090166387P Applic. Date: 2009-04-03

Inventor: ZACHARCHUK CHARLES MICHAEL [US]; BOSCHELLI FRANK CHARLES [US]; GOLAS JENNIFER MICHELE [US]; ARNDT KIM TIMOTHY [US]

Title: PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE

Applicant/Assignee: GENENTECH, INC

Application No.: 12/533935   Filing Date: 31/Jul/2009

Abstract:Disclosed are compounds of Formula I, including steroisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR).

Priority: US20080085309P Applic. Date: 2008-07-31

Inventor: BERGERON PHILIPPE [US]; COHEN FREDERICK [US]; ESTRADA ANTHONY [US]; KOEHLER MICHAEL F T [US]; LAU KEVIN HON LUEN [US]; LY CUONG [US]; LYSSIKATOS JOSEPH P [US]; ORTWINE DANIEL [US]; PEI ZHONGHUA [US]; ZHAO XIANRUI [US]

Title: HYDROPHILIC ORGANOPOLYSILOXANE COMPOSITION FOR USE AS DENTAL IMPRESSION MATERIAL

Applicant/Assignee: GC CORPORATION SHIN-ETSU CHEMICAL CO., LTD

Application No.: 12/251252   Filing Date: 14/Oct/2008

Abstract:A hydrophilic organopolysiloxane composition of the hydrosilylation reaction cure type for use as dental impression material is characterized by comprising as essential components (A) a diorganopolysiloxane having at least 0.1 silicon-bonded alkenyl group in a molecule, (B) a liquid or solid organopolysiloxane having average compositional formula (1), comprising SiO2 units and R3SiO1/2 units (R is a monovalent hydrocarbon, alkoxy or hydroxyl group) and having a viscosity of at least 10 mPas at 23 DEG C., (C) an organohydrogenpolysiloxane having at least two silicon-bonded hydrogen atoms in a molecule, (D) a hydrosilylation catalyst, and (E) a polyether having average compositional formula (2).

Priority: JP20080239551 Applic. Date: 2008-09-18

Inventor: KAMOHARA HIROSHI [JP]; OZAI TOSHIYUKI [JP]; SUGAHARA HIDEKI [JP]

Title: DENTAL SELF-ETCHING PRIMER COMPOSITION

Applicant/Assignee:

Application No.: 12/447874   Filing Date: 26/Oct/2007

Abstract:A dental self-etching primer composition and a dental self-etching primer kit comprising a mixture of (A) a polymerizable monomer, (B) a reducing inorganic compound containing sulfur, (C) a ketone-based solvent and (D) water and having a storage stability of 2 hours or longer at 65 DEG C.

Priority: JP20060294175 Applic. Date: 2006-10-30; WO2007JP71355 Applic. Date: 2007-10-26

Inventor: ARATA MASAMI [JP]; YAMAMOTO AKARI [JP]; KATSURA YOSHIAKI [JP]

Title: ANTIMICROBIAL DENTAL APPLIANCES INCLUDING MOUTHGUARDS AND MOUTHPIECES

Applicant/Assignee:

Application No.: 12/312632   Filing Date: 19/Nov/2007

Abstract:The present invention provides for a dental appliance, mouthguard and/or divers mouthpiece using an anti-microbial composition that combines the use of an elastomeric polymer composition with micronized or submicron sized particles of metal or organo/inorgano metal complexes. In addition, the use of an anti-microbial composition for use with a diver's air delivery hose to prevent breathing of contaminated air is also described.

Priority: US2006-601995 Applic. Date: 2006-11-20; WO2007US24188 Applic. Date: 2007-11-19

Inventor: MASON RICHARD [US]

Title: METHOD OF CLEANING BEVERAGE BOTTLES IN A BEVERAGE BOTTLING PLANT, A METHOD OF CLEANING CONTAINERS IN A CONTAINER FILLING PLANT, AND AN APPARATUS THEREFOR

Applicant/Assignee:

Application No.: 12/408266   Filing Date: 20/Mar/2009

Abstract:A method of cleaning beverage bottles in a beverage bottling plant, a method of cleaning containers in a container filling plant, and an apparatus therefor. The abstract of the disclosure is submitted herewith as required by 37 C.F.R. PRG 1.72(b). As stated in 37 C.F.R. PRG 1.72(b): A brief abstract of the technical disclosure in the specification must commence on a separate sheet, preferably following the claims, under the heading "Abstract of the Disclosure." The purpose of the abstract is to enable the Patent and Trademark Office and the public generally to determine quickly from a cursory inspection the nature and gist of the technical disclosure. The abstract shall not be used for interpreting the scope of the claims. Therefore, any statements made relating to the abstract are not intended to limit the claims in any manner and should not be interpreted as limiting the claims in any manner.

Priority: DE200610044904 Applic. Date: 2006-09-22; WO2007EP07475 Applic. Date: 2007-08-25

Inventor: BAUMGARTNER KLAUS [DE]; KAPPEL STEFFEN [DE]; FAHLDIECK ANDREAS [DE]

Title: INTRAORAL X-RAY SYSTEM

Applicant/Assignee:

Application No.: 12/442163   Filing Date: 25/Sep/2007

Abstract:An improved intraoral x-ray system that includes a dental tray with the shape of a dental arch and can be positioned within the oral cavity, for accommodating image detectors at the lingual (or, palatal) side of the tray

an image processing system, situated external to said oral cavity, for converting the image data detected by the image detector to a viewable image

a mechanism for transferring the image data to the image processing system

and a display unit for displaying the image.

Priority: IL20060178393 Applic. Date: 2006-09-28; WO2007IL01195 Applic. Date: 2007-09-25

Inventor: KAYZERMAN BORIS [IL]

Title: CALCIUM PHOSPHATE DELIVERY VEHICLES FOR OSTEOINDUCTIVE PROTEINS

Applicant/Assignee: WYETH ETEX CORPORATION

Application No.: 12/565159   Filing Date: 23/Sep/2009

Abstract:A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.

Priority: US2007-957691 Applic. Date: 2007-12-17; US2002-160607 Applic. Date: 2002-05-31; US20010296818P Applic. Date: 2001-06-08

Inventor: LI REBECCA [US]; SEEHERMAN HOWARD [US]; TOFIGHI ALIASSGHAR [US]

Title: LIPID GROWTH FACTOR FORMULATIONS

Applicant/Assignee: BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA MBH HEALTHPARTNERS RESEARCH FOUNDATION

Application No.: 12/446884   Filing Date: 23/Oct/2007

Abstract:The present invention is directed to novel formulations and methods for the improved delivery and administration of hydrophobic therapeutic compounds that are substantially insoluble and/or susceptible to precipitation in aqueous solution at physiological pH, including, e.g., growth and differentiation factor-5 and related proteins. Many therapeutic compounds are hydrophobic at physiological pH levels.

Priority: EP20060022159 Applic. Date: 2006-10-23; WO2007EP09198 Applic. Date: 2007-10-23

Inventor: HANSOM LEAH R [US]; FREY II WILLIAM H [US]; HOEKMAN JOHN D [US]; POHL JENS [DE]

Title: METAL-RICH SILICEOUS COMPOSITIONS AND METHODS OF PRODUCING SAME

Applicant/Assignee:

Application No.: 12/628472   Filing Date: 01/Dec/2009

Abstract:A modified sol-gel method to create metal-rich siliceous material, such as colloidal silica or aluminosilicate particles is disclosed. Initially, the metal salt of choice is added to a silicic acid solution or a silicic acid solution containing aluminum salt. The aluminum is added to vary the metal-support interaction as it forms Al-O-Si linkages within the silica matrix. Besides aluminum, other metals can be added that form M-O-Si (M=Ti, B, etc.) linkages, which do not become reduced when treated with a reducing agent. Once the metal, silicic acid and/or aluminum salt is generated, it is subjected to colloidal growth by addition to a basic heel. Upon colloidal synthesis, the metal salt containing colloidal particle is left as is to maximize colloidal stability or is reduced with hydrazine to produce the zero valence metal-containing colloidal particle. Keeping a particle colloidal before use may be an effective method of forming a catalyst material as it can be easily spray-dried or mixed with other materials for extruded catalyst particles.

Priority: US2006-557548 Applic. Date: 2006-11-08

Inventor: HOLLAND BRIAN T [US]

Title: ANALYTE DETECTION

Applicant/Assignee: N2ITIVE1 INNOVATIONS

Application No.: 09/976872   Filing Date: 12/Oct/2001

Abstract:The present invention relates to analyte detection test systems, including test systems for the oral detection of analytes in saliva. The present invention also provides compositions and methods for storing multiple assay tests and compositions and methods for measuring the concentration of analytes in a sample.

Priority: US1999-398552 Applic. Date: 1999-09-17; US2000-698306 Applic. Date: 2000-10-27; US20000243854P Applic. Date: 2000-10-27

Inventor: TORANTO ANTHONY [US]; SINGER EVAN [US]; MILLER BRETT [US]

Title: METHODS FOR TREATING HERPES VIRUS INFECTIONS

Applicant/Assignee: NANOBIO CORPORATION

Application No.: 12/425984   Filing Date: 17/Apr/2009

Abstract:The present invention relates to methods for treating, killing, and/or inhibiting the growth of Herpes viruses in human subjects comprising topically administering to a human subject in need thereof a nanoemulsion composition having antiviral properties.

Priority: US20080046262P Applic. Date: 2008-04-18

Inventor: FLACK MARY R [US]; CIOTTI SUSAN MARIE [US]; HAMOUDA TAREK [US]; SUTCLIFFE JOYCE A [US]; BAKER JR JAMES R [US]

Title: Aminoalcohol Derivatives and Their Therapeutic Use

Applicant/Assignee:

Application No.: 12/517272   Filing Date: 12/Dec/2007

Abstract:A compound of formula (1) Including pharmaceutically acceptable salts thereof, wherein: R1 is aryl or heteroaryl optionally substituted with R8

R2 is H or alkyl or CH2 (when forming part of a ring with R3, R4 or R5)

R3 is H, alkyl, CH2OH or CH2OR6 and can be part of a ring with R2

R4 is H, alkyl, CH2OH or CH2OR6 and can be part of a ring with R2

R5 is H, alkyl, CH2OH or CH2OR6 and can be part of a ring with R2

R6 is H, alkyl, COH, COOR9, CON(R9)2, COR9, COR10, COR11, P(O)nR9, P(O)nR10S(O)nR10 or S(O)nR9 and can be part of a ring with R2, R3, R4 or R5

R7 is H, alkyl, COOR9, COOR11, COR9 or CON(R9)2, and can be part of a ring with R2, R3, R4, R5 or R6

R8 is alkyl, CF3, OR9, OCOR9, CONH2, CN, F, Cl, Br, I, N(R9)2, NO2, NHCHO, NHCONH2, NHSO2R9, CON(R9)2, S(O)nR9, CH2OH Or OCON(R9)2

R9 is H, alkyl or cycloalkyl

R10 is aryl or heteroaryl (optionally substituted with R8) or a four to seven membered ring (which is optionally substituted with R8 and can contain one or more additional heteroatoms selected from the list O, S(O)n and NR9)

R11 is alkyl optionally substituted with R8 or R10

and n is O, 1 or 2

provided that when R3, R4 or R5 is CH2OH then R6 is not H, and that when R7 is H and R3, R4 and R5 are alkyl then R6 is not H. is of therapeutic use in the treatment of a condition associated with T-cell proliferation or that is mediated by pro- and/or anti-inflammatory cytokines.

Priority: GB20060024757 Applic. Date: 2006-12-12; WO2007GB04752 Applic. Date: 2007-12-12

Inventor: WALMSLEY ANDREA [GB]; LASTERRA ELENA [GB]

Title: Synthesis of Cyclohexane Derivatives Useful as Sensates in Consumer Products

Applicant/Assignee:

Application No.: 12/541428   Filing Date: 14/Aug/2009

Abstract:The present invention provides synthetic routes for preparing various isomers of cyclohexane-based coolants, such as menthyl esters and menthanecarboxamide derivatives, in particular those substituted at the amide nitrogen, for example with an aromatic ring or aryl moiety. Such structures have high cooling potency and long lasting sensory effect, which make them useful in a wide variety of consumer products. One synthetic route involves a copper catalyzed coupling of a primary menthanecarboxamide with an aryl halide, such reaction working best in the presence of potassium phosphate and water. Using this synthetic route, specific isomers can be prepared including the menthanecarboxamide isomer having the same configuration as l-menthol and new isomers such as a neoisomer having opposite stereochemistry at the carboxamide (C-1) position. The neoisomer unexpectedly has potent and long lasting cooling effect. Preparation schemes for neoisomers of other menthyl derivatives which are useful as coolants, including esters, ethers, carboxy esters and other N-substituted carboxamides are also provided.

Priority: US20080089094P Applic. Date: 2008-08-15

Inventor: YELM KENNETH EDWARD [US]; BUNKE GREGORY MARK [US]; HAUGHT JOHN CHRISTIAN [US]

Title: ANTIMICROBIAL GEL FORMULATIONS

Applicant/Assignee: NOVABAY PHARMACEUTICALS, INC

Application No.: 12/540251   Filing Date: 12/Aug/2009

Abstract:Disclosed herein are formulations comprising an N-halogenated or N,N-dihalogenated amine compound dispersed in a water-swellable polymer, wherein the compound is 90% stable for at least 30 days at about 25 DEG C. Also disclosed are methods of treating or preventing infections caused by a bacterial, a microbial, a sporal, a fungal or a viral activity using such formulations.

Priority: US20080088302P Applic. Date: 2008-08-12; US20090229624P Applic. Date: 2009-07-29

Inventor: WANG LU [US]; NAJAFI AZAR [US]; MEMARZADEH BAHRAM [US]; SHARMA KULDEEPAK [US]; HO KIM PHUONG [US]

Title: Compositions For Dental Composites With Tricyclo[5.2.1.02.6]decane Derivatives

Applicant/Assignee: HERAEUS KULZER GMBH

Application No.: 12/614560   Filing Date: 09/Nov/2009

Abstract:Dental composites comprising monomers, crosslinking agents, fillers, and initiators, in which the crosslinking agent comprises more than 50% by weight of the acrylate monomer TCD-DI-HEA, and the cyctotoxicity of the cured composite as determined according to the standard requirements of ISO 10993-5 and DIN EN ISO 7405 is assessed into the category "no cytotoxic potential".

Priority: DE200610060983 Applic. Date: 2006-12-20; US2007-953120 Applic. Date: 2007-12-10

Inventor: UTTERODT ANDREAS [DE]; RUPPERT KLAUS [DE]; SCHAUB MATTHIAS [DE]; DIEFENBACH CHRISTINE [DE]; REISCHL KURT [DE]; HOHMANN ALFRED [DE]; ECK MICHAEL [DE]; SCHOENHOF NELLI [DE]

Title: STABLE, CONCENTRATED AND DILUTE, OIL-IN-WATER EMULSIONS, THEIR PROCESSES OF PREPARATION, AND FORMULATION PROCESS EMPLOYING THESE EMULSIONS

Applicant/Assignee: J & C INTERNATIONAL

Application No.: 12/630870   Filing Date: 04/Dec/2009

Abstract:A stable oil-in-water emulsion, a process for the preparing such emulsion, and a formulation process employing the emulsion. The stable oil-in-water emulsion is obtained from an air-in-water preemulsion to which a simple or complex fatty substance is added by moderate mixing, preferably without exerting a shear force. The air-in-water preemulsion includes a surfactant, preferably a nonionic surfactant, a co surfactant chosen from hydrophilic compounds, preferably having at least one hydroxyl group, which are chosen in particular from the family of the polyols, and an aqueous phase. The ratios of these three components of the preemulsion are chosen within the region of ordered liquid crystal structure of the phase diagram of these three components and/or in ratios chosen so that the structure of the mixture of these three components, observed under a microscope in polarized light, exhibits birefringence characteristics.

Priority: FR20030009861 Applic. Date: 2003-08-12; US2004-487786 Applic. Date: 2004-08-23; WO2004FR00122 Applic. Date: 2004-01-20

Inventor: ROSSOW VERONIQUE [FR]; ROSSOW NICOLAS [FR]; ROSSOW JEAN [FR]

Title: METHOD AND MEANS FOR CULTURING OSTEOBLASTIC CELLS

Applicant/Assignee: ASCENDIA AB

Application No.: 12/598811   Filing Date: 02/May/2008

Abstract:A method of culturing human or mammalian mesenchymal stem cells (MSC) or osteoblastic cells to form corresponding cell aggregates evenly distributed in the culturing medium having a reduced content of cells with fibroblast morphology comprises contacting MSC or OC with a water-soluble cellulose derivative over a period of from 1 day to one or two weeks. Also disclosed are a corresponding aggregates, a culture medium and a pharmaceutical composition, and uses of the aggregate, the culturing medium and the composition.

Priority: SE20070001078 Applic. Date: 2007-05-04; WO2008SE00307 Applic. Date: 2008-05-02

Inventor: BUSCH CHRISTER [SE]

Title: DENTAL ROOT CANAL-FILLING COMPOSITION

Applicant/Assignee: GC CORPORATION

Application No.: 12/560917   Filing Date: 16/Sep/2009

Abstract:To provide a dental root canal-filling composition which is generally formed in a point shape, has high strength, is properly deformed so as to afford easy operativity for filling in a root canal, has improved wetting and adhering properties with a root canal-filling sealer and is less deteriored by sterilization or chemical disinfection, the dental root canal-filling composition comprises one or more kinds of polyolefin resins selected from the group of polyethylene, polypropylene, and a copolymer of polyethylene and polypropylene, a styrene block copolymer, one or more kinds of thermoplastic resins selected from the group of ester gum, rosin, an alicyclic saturated hydrocarbon resin, a terpene resin, and an aliphatic petroleum resin, and one or more kinds of inorganic fillers selected from the group of zinc oxide, barium sulfate, zirconium oxide, titanium oxide, ytterbium fluoride, a barium glass, and an aluminosilicate glass.

Priority: JP20080251990 Applic. Date: 2008-09-30

Inventor: SHINOZAKI YUTAKA [JP]; KAMOHARA HIROSHI [JP]

Title: Mixable and color tone freely reproducible dental coloring material composition, and set and method thereof

Applicant/Assignee: KABUSHIKI KAISHA SHOFU

Application No.: 12/458141   Filing Date: 01/Jul/2009

Abstract:A dental coloring material composition comprising containing: (a) a polymerizable monomer and/or an oligomer, (b) a polymerization catalyst, and (c) a pigment and/or a dye, wherein a color tone thereof is a cyan color based on three subtractive primary colors, or a color tone thereof is a magenta color based on three subtractive primary colors, or a color tone thereof is a yellow color based on three subtractive primary colors, and a dental color material set using the dental coloring material compositions in combination.

Priority: JP20080256427 Applic. Date: 2008-10-01

Inventor: UCHIDA JUN [JP]; OKIMOTO YUSHIN [JP]; TERAMAE MITSUJI [JP]; MIZUNO MITSUHARU [JP]

Title: Lithium silicate glass ceramic for fabrication of dental appliances

Applicant/Assignee: JAMES R., GLIDEWELL DENTAL CERAMICS, INC

Application No.: 12/592825   Filing Date: 03/Dec/2009

Abstract:The present invention relates to preparing an improved lithium silicate glass ceramic for the manufacture of blocks for dental appliance fabrication using a CAD/CAM process and hot pressing system. The lithium silicate material has a chemical composition that is different from those reported in the prior art with 1 to 10% of germanium dioxide in final composition. The softening points are close to the crystallization final temperature of 830 DEG C. indicating that the samples will support the temperature process without shape deformation.

Priority: US2008-283472 Applic. Date: 2008-09-12; US2008-082576 Applic. Date: 2008-04-11

Inventor: CASTILLO RODOLFO [US]

Title: SCREW PRESS FOR COMPACTING SOLID WASTE

Applicant/Assignee:

Application No.: 12/522007   Filing Date: 17/Jan/2008

Abstract:Screw press, with small dimensions, particularly suitable for the compaction of solid waste for disposal also by means of sorted-waste collection, of the type which comprises an initial large-diameter screw section with a wide-pitch helix, communicating laterally with the bottom opening of the loading hopper (1) in order to remove the material from it and feed it to a following small-diameter screw section with a small-pitch helix, surrounded by an internally scored stator body so as to produce the feeding and compaction of the material which also occurs in conjunction with the action of constriction means which act on the discharge mouth of this latter screw section, a press of this type being characterized in that the two said aforementioned screw sections (3, 4) are separated and arranged parallel to each other and one above or around each other, so as to form overall a press which no longer has as its length the sum of the lengths of the said two screw sections, but which has a length corresponding to the length of the longer of the two screw sections, means being envisaged for operating said two screw sections at different speeds, with the second compacting screw section (4) which rotates at a speed greater than that of the first feeder screw section (3).

Priority: IT2007BO00021 Applic. Date: 2007-01-18; WO2008EP50498 Applic. Date: 2008-01-17

Inventor: SALDA LUCIANO [IT]

Title: Container Closure Comprising a Cable Tie

Applicant/Assignee: JUNKK.COM LIMITED

Application No.: 12/445577   Filing Date: 17/Oct/2007

Abstract:A tamper evident lid assembly (10) for a mouth of a container (12) comprises a lid (15) to close the mouth of the container, and a strip (14) preventing removal of the lid. Removal or disconnection of the strip (14) enables the lid (15) to be removed. The strip (14) defines at one end a block (20) with an aperture (24), and also defines serrated teeth (22) along at least part of its length, such that after removing the strip from the lid assembly it may be used as a cable tie.

Priority: GB20060020483 Applic. Date: 2006-10-17; WO2007GB50641 Applic. Date: 2007-10-17

Inventor: MARTIN PETER JOHN [GB]

Title: Method for Girth Welding Metallic Pipes

Applicant/Assignee:

Application No.: 12/593561   Filing Date: 17/Mar/2008

Abstract:A method for girth welding of metallic pipes consists in beveling one pipe end in order that, when it is aligned with an identically beveled pipe end on another pipe, results in a bevel of a "cruet" design with a rounded bottom part larger than an upper part with parallel walls. The diameter of the welding wire used for the welding method is within 1.2 and 1.4 mm and the wire contains low levels of impurity including sulfur and phosphorus. The welding technique used is a "strip" technique which does not provide employ weaving or oscillation of the welding torch.

Priority: IT2007PD00117 Applic. Date: 2007-03-29; WO2008US03510 Applic. Date: 2008-03-17

Inventor: BELLONI ANTONIO [IT]; BELLONI MARCO [IT]

Title: TOOTH WHITENING COMPOSITION

Applicant/Assignee:

Application No.: 12/300351   Filing Date: 11/May/2007

Abstract:The present invention provides an effective tooth whitening composition comprising a chlorine dioxide precursor, an organic acid anhydride and an orally acceptable carrier.

Priority: GB20060009485 Applic. Date: 2006-05-12; WO2007EP54601 Applic. Date: 2007-05-11

Inventor: BURNETT GARY ROBERT [GB]; GORDON JENNIFER JANE [GB]; VELADA JOSE LUIS [GB]

Title: NOVEL BACTERIA ISOLATED FROM FRESH HONEY OR THE HONEY PRODUCING TRACT OF HONEY BEES

Applicant/Assignee:

Application No.: 12/598509   Filing Date: 30/Apr/2008

Abstract:The invention relates to new isolated Lactobacillus and Bifidobacterium strains which have been isolated from fresh honey having a water content above 18% by weight or from the honey producing tract of at least one bee. The bacterial strains have unique properties rendering them useful in many products such as in food and beverage products, feed products and medica products.

Priority: SE20070001050 Applic. Date: 2007-05-03; US20070916809P Applic. Date: 2007-05-09; WO2008SE00303 Applic. Date: 2008-04-30

Inventor: OLOFSSON TOBIAS [SE]; VASQUEZ ALEJANDRA [SE]

Title: Methods and Systems for Mineralization of Demineralized Tissue

Applicant/Assignee: MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC

Application No.: 12/576058   Filing Date: 08/Oct/2009

Abstract:Disclosed are systems, methods, compositions and kits for mineralizing tissue, particularly dental tissue. The methods, compositions and kits may be used to strengthen and prevent weakening of the tissue. For example, the methods, compositions and kits may be used for treating and filling cavities in teeth caused by tooth decay.

Priority: US20080195561P Applic. Date: 2008-10-08

Inventor: PASHLEY DAVID HENRY [US]; TAY FRANKLIN CHI-MENG [US]

Title: TOOTH WHITENING APPARATUS

Applicant/Assignee:

Application No.: 12/519214   Filing Date: 14/Dec/2006

Abstract:Provided is a tooth whitening apparatus. The tooth whitening apparatus includes a whitening unit having a light emitting part emitting light to all of teeth of a patient

and a wearable set to which the whitening unit is mounted, the wearable set being worn on head of the patient.

Priority: WO2006KR05453 Applic. Date: 2006-12-14

Inventor: JUN JONG-CHAN [KR]

Title: ELASTIC TEMPORARY SUPRACONSTRUCTION FOR A DENTAL IMPLANT

Applicant/Assignee: VOCO GMBH

Application No.: 12/442963   Filing Date: 26/Sep/2007

Abstract:A temporary supraconstruction for a dental implant or a core for a temporary supraconstruction for a dental implant, characterized in that it includes a material having a modulus of elasticity of less than 300 MPa, preferably in the range of from 15 to 20 MPa.

Priority: DE200610045466 Applic. Date: 2006-09-26; WO2007EP60236 Applic. Date: 2007-09-26

Inventor: SCHULZ-WALZ JAN ERIK [DE]

Title: ELECTRICAL TERMINATION

Applicant/Assignee: TYCO ELECTRONICS CORPORATION

Application No.: 12/244507   Filing Date: 02/Oct/2008

Abstract:A crimped wire termination is disclosed for electrically terminating thereto a stainless steel wire. The termination includes a barrel having a concave spine and opposing fingers on either end of the spine extending outwardly from the spine at symmetrical angles. The fingers are adapted to encircle an end of a wire. An indentation formed in the spine when crimped. The indentation forms a segment of the barrel having a cross-sectional diameter less than a cross-sectional diameter of an adjacent end of the barrel, and forms a bend in the wire at opposite ends of the segment, to prevent axial movement through the barrel.

Priority:

Inventor: DECKER DONALD F [US]; DESANTIS PETE [US]; PORTA GARY D [US]; HOWARD EDWARD J [US]; SCHWARTZ THOMAS G [US]

Title: INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF

Applicant/Assignee: ABBOTT LABORATORIES

Application No.: 12/568085   Filing Date: 28/Sep/2009

Abstract:The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

Priority: US20080101054P Applic. Date: 2008-09-29; US20090225452P Applic. Date: 2009-07-14

Inventor: SCHRIMPF MICHAEL R [US]; LEE CHIH-HUNG [US]; LI TAO [US]; GFESSER GREGORY A [US]; MORTELL KATHLEEN H [US]; FAGHIH RAMIN [US]; NERSESIAN DIANA L [US]; SIPPY KEVIN B [US]; BUNNELLE WILLIAM H [US]; SCANIO MARC [US]; SHI LEI [US]; GOPALAKRISHNAN MURALI [US]; DONNELLY-ROBERTS DIANA L [US]; HU MIN [US]

Title: SUBSTITUTED PHENYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS

Applicant/Assignee: PFIZER INC

Application No.: 12/445500   Filing Date: 11/Oct/2007

Abstract:This invention provides a compound of the formula (I). These compounds are useful for the treatment of disease conditions caused by overactivation of the VR1 receptor such as pain, or the like in mammal. This invention also provides a pharmaceutical composition comprising the above compound.

Priority: US20060862485P Applic. Date: 2006-10-23; WO2007IB03106 Applic. Date: 2007-10-11

Inventor: ANDO KOJI [JP]; TANAKA HIROTAKA [JP]

Title: SULPHONIUM SALT PHOTOINITIATORS

Applicant/Assignee:

Application No.: 12/442823   Filing Date: 24/Sep/2007

Abstract:Compounds of the formula (I), wherein L1, L2, L3 and L4 independently of one another are hydrogen or an organic substituent

R is for example C1-C20alkyl, C5-C12cycloalkyl, C2-C20alkenyl, substituted C1-C20alkyl

X is O, S, NRa or NCORa

Ra is for example hydrogen or C1-C20alkyl

and Y is an inorganic or organic anion

are suitable as photolatent acid generators.

Priority: EP20060121699 Applic. Date: 2006-10-04; WO2007EP60074 Applic. Date: 2007-09-24

Inventor: HAYOZ PASCAL [CH]; BIRBAUM JEAN-LUC [CH]; ILG STEPHAN [CH]

Title: Dental Composites with a Low Shrinkage Tension and High Flexural Strength

Applicant/Assignee: HERAEUS KULZER GMBH

Application No.: 12/635114   Filing Date: 10/Dec/2009

Abstract:Dental composite materials based on (meth)acrylate, exhibiting a proportion of TCD monomers in the total composition of 1-15% by weight and the quotient of flexural strength/shrinkage tension is at least 35.

Priority: DE200710034457 Applic. Date: 2007-07-20; US2008-168512 Applic. Date: 2008-07-07

Inventor: UTTERODT ANDREAS [DE]; RUPPERT KLAUS [DE]; SCHAUB MATTHIAS [DE]; DIEFENBACH CHRISTINE [DE]; REISCHL KURT [DE]; HOHMANN ALFRED [DE]; ECK MICHAEL [DE]; SCHONHOF NELLI [DE]; SCHNEIDER JUTTA [DE]

Title: DIVIDED REDOX-CURING TYPE COMPOSITION

Applicant/Assignee: KURARAY MEDICAL INC

Application No.: 12/524043   Filing Date: 16/Jan/2008

Abstract:The present invention provides a divided redox-curing type composition including a first part in which at least an oxidizing agent (b) is dissolved in a first radical monomer including a radical monomer (a) having an acidic group and/or a hydrophilic group

and a second part in which at least an aromatic sulfinate (d) is dispersed in a second radical monomer including a radical monomer (c) having neither an acidic group nor a hydrophilic group. According to the present invention, a redox-curing type composition capable of securing a time necessary for an adhesion operation and exhibiting high bond strength not only at the initial stage of adhesion but also over a long period of time thereafter in application to a wetting material such as a tooth or a bone as well as a tooth crown repairing material such as a metal or porcelain.

Priority: JP20070012740 Applic. Date: 2007-01-23; WO2008JP50399 Applic. Date: 2008-01-16

Inventor: TAKEI MITSURU [JP]; NAKAYAMA HIDEMI [JP]; SHINODA HIROKI [JP]

Title: Integrated Locking Device With Fluid Control

Applicant/Assignee: BOSTON SCIENTIFIC SCIMED, INC

Application No.: 12/467968   Filing Date: 18/May/2009

Abstract:Endoscope assemblies, biopsy caps, and methods for making and using the same. An example endoscope assembly may include an endoscope having a channel formed therein and a port that provides access to the channel. A cap may be coupled to the port. The cap may include a base having a securing member for securing the cap to the port. The cap may also include an outer shell, a locking member coupled to the outer shell, an inner seal member disposed within the outer shell, and one or more openings extending through the cap and into the channel. A fluid control region may be defined within the outer shell.

Priority: US20080054413P Applic. Date: 2008-05-19

Inventor: WELDON JAMES M [US]; BYERS RANSOM H [US]; DILLON ALEXANDER E [US]; KOCHEM THOMAS C [US]; RICE DANIEL W [US]; SCHMIDT ALLISON L [US]; NIX LILLY [US]; CLARK LARA [US]; DONOHOO PEARL E [US]; HOLLETT ANDREW K [US]; LITTLE CHANDRA [US]

Title: Collection Device for Sampling Exhaled Airstreams

Applicant/Assignee:

Application No.: 12/524781   Filing Date: 31/Jan/2008

Abstract:A collection device (10), such as a mask, for collecting constituents of interest present in an airstream exhaled by a subject The collection device comprises a support member (12) mountable external to the nose and/or mouth of the subject, and at least one collection region (13) mounted to the support member (12) for collecting at least some of said constituents. The constituents are collected in a manner that allows subsequent analysis of the constituents. When the support member (12) is mounted over the nose and/or mouth of the subject, at least some of the exhaled airstream passes through the at least one collection region (13).

Priority: AU20070900458 Applic. Date: 2007-01-31; AU20070903984 Applic. Date: 2007-07-25; WO2008AU00100 Applic. Date: 2008-01-31

Inventor: TOVEY EUAN ROGER [AU]

Title: BIOCIDIC MEDICAL DEVICES, IMPLANTS AND WOUND DRESSINGS

Applicant/Assignee: OPLON B.V

Application No.: 12/598429   Filing Date: 03/Apr/2008

Abstract:The present invention discloses a medical device selected from a group consisting of medical devices, implants wound dressings, comprises at least one insoluble proton sink or source (PSS). The medical device is provided useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact. The PSS comprises, inter alia, (i) proton source or sink providing a buffering capacity

and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of the LTCs' environment.

Priority: US20070924154P Applic. Date: 2007-05-01; WO2008IL00467 Applic. Date: 2008-04-03

Inventor: BUKSHPAN SHMUEL [IL]; ZILBERSTEIN GLEB [IL]

Title: ROTARY UNITS, ROTARY MECHANISMS, AND RELATED APPLICATIONS

Applicant/Assignee:

Application No.: 12/577326   Filing Date: 12/Oct/2009

Abstract:The invention relates to rotary units and rotary mechanisms that are suitable for use in numerous applications. Rotary units typically include rotational components that are configured to rotate. In some embodiments, for example, multiple rotary units are assembled in rotary mechanisms such that neighboring pairs of rotational components counter-rotate or contra-rotate relative to one another during operation of the rotary mechanisms. Rotational components generally include one or more implements that are structured to perform or effect one or more types of work as the rotational components rotate relative to one another in a given rotary mechanism. In certain embodiments, implements are configured to rotate and/or to effect the movement of other components as rotational components rotate.

Priority: US20080104748P Applic. Date: 2008-10-12

Inventor: SAPPENFIELD CHRISTOPHER C [US]

Title: PLASTIC BOTTLE WITH A MOUTH

Applicant/Assignee: THE COCA-COLA COMPANY

Application No.: 12/251663   Filing Date: 15/Oct/2008

Abstract:To provide a plastic bottle whose weight can be reduced without sacrificing strength of a bottle mouth, the plastic bottle is provided with a bottle mouth having a circumferential wall, including a threaded section formed on an outer circumferential surface of the circumferential wall, a support ring protruding from the outer circumferential surface below the threaded section, and punched sections formed on the circumferential wall.

Priority:

Inventor: MATSUOKA KENSHI [JP]

Title: ADHESIVE COMPOSITION FOR HARD TISSUE

Applicant/Assignee:

Application No.: 12/520703   Filing Date: 17/Dec/2007

Abstract:An adhesive composition including an etchant for a hard tissue surface, at least one multifunctional crosslinkable (meth)acrylate monomer with a functionality greater than 4, and water. The adhesive composition is a water-in-oil emulsion.

Priority: US20060877514P Applic. Date: 2006-12-28; WO2007US87711 Applic. Date: 2007-12-17

Inventor: RAO PRABHAKARA S [US]; AASEN STEVEN M [US]; ABUELYAMAN AHMED S [US]; MITRA SUMITA B [US]; CRAIG BRADLEY D [US]; SHUKLA BRIAN A [US]; PLAUT DAVID J [US]; RUSSELL VICTORIA A [US]

Title: Systems, Methods, and Compositions for Treatment and Use of a Palatal Patch

Applicant/Assignee:

Application No.: 12/440024   Filing Date: 15/Aug/2007

Abstract:Devices and methods for a palatal patch include a tablet or strip having a bioadhesive component and an active component. The bioadhesive component allows for the palatal patch to be attached to an upper palate, and for the active component to be released into the oral cavity and/or GI tract. Compositions for the active component include compositions for treatment of halitosis, anti-acids, vitamins, anti-smoking agents, and others. A composition for treatment of halitosis includes at least one of Echinacea, Lavender, Mastic Gum and Sage. A device for delivery of the palatal patch to the upper palate includes a housing and a piston, the piston having a holder for the palatal patch, and wherein the piston may be configured to move distally so as to delivery the palatal patch to the upper palate.

Priority: US20060824476P Applic. Date: 2006-09-05; WO2007IL01024 Applic. Date: 2007-08-15

Inventor: PEREZ-DAVIDI MICHAEL MOSHE [IL]; STERER NIR [IL]; WEISS ERVIN ITZCHAK [IL]; DOMB AVRAHAM JACOB [IL]

Title: PEPTIDES, DERIVATIVES AND ANALOGS THEREOF, AND METHODS OF USING SAME

Applicant/Assignee: CUREDM, INC

Application No.: 12/635053   Filing Date: 10/Dec/2009

Abstract:Human proIslet Peptides (HIP) and HIP analogs and derivatives thereof, derived from or homologous in sequence to the human REG3A protein, chromosome 2p12, are able to induce islet neogenesis from endogenous pancreatic progenitor cells. Human proIslet Peptides are used either alone or in combination with other pharmaceuticals in the treatment of type 1 and type 2 diabetes and other pathologies related to aberrant glucose, carbohydrate, and/or lipid metabolism, insulin resistance, overweight, obesity, polycystic ovarian syndrome, eating disorders and the metabolic syndrome.

Priority: US2008-121123 Applic. Date: 2008-05-15; US2006-441491 Applic. Date: 2006-05-25; US20050684819P Applic. Date: 2005-05-25

Inventor: LEVETAN CLARESA S [US]; UPHAM LORAINE V [US]

Title: NITROSATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE

Applicant/Assignee:

Application No.: 12/636329   Filing Date: 11/Dec/2009

Abstract:The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever

for treating gastrointestinal disorders

for facilitating wound healing

for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds

for treating inflammatory disease states and/or disorders

and for treating and/or preventing ophthalmic diseases and/or disorders.

Priority: US2005-134358 Applic. Date: 2005-05-23; US2003-612014 Applic. Date: 2003-07-03; US20020393111P Applic. Date: 2002-07-03; US20020397979P Applic. Date: 2002-07-24; US20020418353P Applic. Date: 2002-10-16; US20030449798P Applic. Date: 2003-02-26; US20030456182P Applic. Date: 2003-03-21

Inventor: EARL RICHARD A [US]; EZAWA MAIKO [US]; FANG XINQIN [US]; GARVEY DAVID S [US]; GASTON RICKY D [US]; KHANAPURE SUBHASH P [US]; LETTS L GORDON [US]; LIN CHIA-EN [US]; RANATUNGE RAMANI R [US]; RICHARDSON STEWART K [US]; SCHROEDER JOSEPH D [US]; STEVENSON CHERI A [US]; WEY SHIOW-JYI [US]

Title: AMINOTRIAZOLOPYRIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH

Applicant/Assignee:

Application No.: 12/555018   Filing Date: 08/Sep/2009

Abstract:Provided herein are Heteroaryl Compounds of formula (I): wherein R1 and R2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.

Priority: US20080095217P Applic. Date: 2008-09-08; US20090230479P Applic. Date: 2009-07-31

Inventor: BAHMANYAR SOGOLE [US]; BATES R J [US]; BLEASE KATE [US]; CALABRESE ANDREW ANTONY [US]; DANIEL THOMAS ORAN [US]; DELGADO MERCEDES [US]; ELSNER JAN [US]; ERDMAN PAUL [US]; FAHR BRUCE [US]; FERGUSON GREGORY [US]; LEE BRANDEN [US]; NADOLNY LISA [US]; PACKARD GARRICK [US]; PAPA PATRICK [US]; PLANTEVIN-KRENITSKY VERONIQUE [US]; RIGGS JENNIFER [US]; ROHANE PATRICIA [US]; SANKAR SABITA [US]; SAPIENZA JOHN [US]; SATOH YOSHITAKA [US]; SLOAN VICTOR [US]; STEVENS RANDALL [US]; TEHRANI LIDA [US]; TIKHE JAYASHREE [US]; TORRES EDUARDO [US]; WALLACE ANDREW [US]; WHITEFIELD BRANDON WADE [US]; ZHAO JINGJING [US]

Title: NITROSATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE

Applicant/Assignee:

Application No.: 12/636306   Filing Date: 11/Dec/2009

Abstract:The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever

for treating gastrointestinal disorders

for facilitating wound healing

for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds

for treating inflammatory disease states and/or disorders

and for treating and/or preventing ophthalmic diseases and/or disorders.

Priority: US2005-134358 Applic. Date: 2005-05-23; US2003-612014 Applic. Date: 2003-07-03; US20020393111P Applic. Date: 2002-07-03; US20020397979P Applic. Date: 2002-07-24; US20020418353P Applic. Date: 2002-10-16; US20030449798P Applic. Date: 2003-02-26; US20030456182P Applic. Date: 2003-03-21

Inventor: EARL RICHARD A [US]; EZAWA MAIKO [US]; FANG XINQIN [US]; GARVEY DAVID S [US]; GASTON RICKY D [US]; KHANAPURE SUBHASH P [US]; LETTS L GORDON [US]; LIN CHIA-EN [US]; RANATUNGE RAMANI R [US]; RICHARDSON STEWART K [US]; SCHROEDER JOSEPH D [US]; STEVENSON CHERI A [US]; WEY SHIOW-JYI [US]

Title: 5,6,7,8-TETRAHYDRO-IMIDAZO[1,5-A]PYRAZINE DERIVATIVES

Applicant/Assignee:

Application No.: 12/520693   Filing Date: 20/Dec/2007

Abstract:The invention relates to 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives of formula (I), wherein X represents CH2 or O

R1 represents a phenyl group, which group is independently mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C1-4)alkyl, (C1-4)alkoxy, halogen, cyano, trifluoromethoxy and trifluoromethyl

R2 represents (C1-4)alkyl, (C1-4)alkoxy, (C2-4)alkenyl, halogen, cyano, hydroxymethyl, trifluoromethyl, C(O)NR5R6 or cyclopropyl

R3 represents (C1-4)alkyl, (C1-4)alkoxy-methyl or halogen

R4 represents (C1-4)alkyl

R5 represents hydrogen or (C1-4)alkyl

and R6 represents hydrogen or (C1-4)alkyl. The invention also relates to pharmaceutically acceptable salts of such compounds

and to the use of such compounds as medicaments

especially as orexin receptor antagonists.

Priority: WO2006IB55019 Applic. Date: 2006-12-22; WO2007IB55245 Applic. Date: 2007-12-20

Inventor: AISSAOUI HAMED [FR]; BOSS CHRISTOPH [CH]; GUDE MARKUS [CH]; KOBERSTEIN RALF [DE]; SIFFERLEN THIERRY [FR]

Title: HETEROCYCLIC BENZIMIDAZOLES AS TRPM8 MODULATORS

Applicant/Assignee:

Application No.: 12/576283   Filing Date: 09/Oct/2009

Abstract:Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein W1, W2, W3, R1, R1a, R2, R2a, R3, V, Q, and X are defined herein.

Priority: US20080105449P Applic. Date: 2008-10-15

Inventor: PLAYER MARK R [US]; PARKS DANIEL J [US]; PARSONS WILLIAM [US]; MEEGALLA SENATH K [US]; ILLIG CARL R [US]; BALLENTINE SHELLEY K [US]

Title: SELF-CLEANING WIRELESS VIDEO STYLET WITH DISPLAY MOUNTED TO LARYNGOSCOPE BLADE AND METHOD FOR USING THE SAME

Applicant/Assignee:

Application No.: 12/623552   Filing Date: 23/Nov/2009

Abstract:A scope adapted for insertion and manipulation in a difficult pathway is disclosed. The scope comprises at least one module for manipulating the scope. The scope may further comprise an illumination source, an image sensor, a power source, and a viewing member for viewing images of a cavity or other anatomical member of a patient. In one embodiment the scope is intended to facilitate insertion of an intubating device, which comprises an elongated semi-rigid stylet including first and second ends and at least one inner lumen connected to a module. Additionally, a flexible tip is provided for manipulating one end of the scope and allowing greater flexibility when maneuvering a difficult pathway. In another embodiment, fluids are provided through an interior portion of the scope, allowed to at least partially contact the lens located at the distal end of the scope, and subsequently cleanse or defog the lens for improving vision via the scope. A method for navigating a difficult pathway and for using the apparatus described herein is also disclosed.

Priority: US2008-253729 Applic. Date: 2008-10-17; US2008-020862 Applic. Date: 2008-01-28

Inventor: MEJIA MAURICIO [US]

Title: BUCKET THAT IS APPLICABLE INTERCHANGEABLY TO OPERATING MACHINES PROVIDED WITH HYDRAULIC OR ELECTRIC PLANT

Applicant/Assignee:

Application No.: 12/311925   Filing Date: 30/Aug/2007

Abstract:A bucket (B) that is applicable interchangeably to operating machines provided with hydraulic or electric plant, equipped with one or more rotors (R) actuated by one or more hydraulic or electric (M) engines or gear motors fed by the hydraulic or electric circuit resting inside operating machines or outside the bucket.

Priority: IT2006BO00722 Applic. Date: 2006-10-20; WO2007IB02500 Applic. Date: 2007-08-30

Inventor: RISI MIRCO [IT]

Title: Symbiotic Containment Enclosure

Applicant/Assignee:

Application No.: 12/426510   Filing Date: 20/Apr/2009

Abstract:A package for, interacting symbiotically, integrally and exclusively with and for patent application number 11758760 electromagnetic circuit. Such package is comprised of one or more layers of materials moderating the circuits electromagnetic field within. Such a package has proximal inductors that are electromagnetic conduits for input and output of electromagnetic energy terminating proximally in relation to the circuit within.

Priority: US2007-758760 Applic. Date: 2007-06-06

Inventor: MECCA JOHN [US]

Title: ORAL HEALTH COMPOSITION

Applicant/Assignee: MARS INCORPORATED

Application No.: 12/516294   Filing Date: 27/Nov/2007

Abstract:The present invention relates to Orthosiphon spicatus for use in oral health applications, an oral composition comprising Orthosiphon spicatus, and the use of Orthosiphon spicatus or the composition, in the improvement or maintenance of oral health in an animal, preferably through the reduction or control of dental plaque and/or alteration of the bacterial content of dental plaque, in the oral cavity of the animal. The invention also includes Orthosiphon spicatus for use in the prevention or treatment of gingivitis in an animal. The invention also provides a method for improving or maintaining oral health in an animal.

Priority: GB20060023618 Applic. Date: 2006-11-27; WO2007GB04526 Applic. Date: 2007-11-27

Inventor: MARSHALL-JONES ZOE [GB]; BAILLON MARIE-LOUISE [GB]; BUCKLEY CATHERINE [GB]

Title: METHODS, PROCESSES AND COMPOSITIONS COMPRISING THE PROTEIN CALMODULIN (CAM) FOR TREATMENT OF DAMAGED OR AGING SKIN, AND/OR HAIR LOSS

Applicant/Assignee:

Application No.: 12/449916   Filing Date: 21/Mar/2007

Abstract:The invention relates to compositions comprising the calcium binding protein, calmodulin (CaM), and the use of this protein additive in compositions suitable for topical application for the maintenance and development of healthy skin

for improving the aesthetic appearance of skin

for treating fine lines, and/or wrinkles, and/or age spots, and/or minor wounds and burns, and/or calloused skin-through its facilitation of natural healing processes initiated by disease, injury or aging

for enhancing hair growth

and as a cosmetic treatment process comprising application to the skin the compositions, preferably on a daily basis. The compositions may comprise, but not be limited to, UV blocking agents and/or penetration enhancers and/or one or more bio-active agents. CaM can be formulated into therapeutic compositions as lotions, creams, ointments, sprays, gels, skin coverings and wound dressings.

Priority: WO2007IB02725 Applic. Date: 2007-03-21

Inventor: TIPPENS DORR FELT [US]

Title: Nitric oxide releasing particles for oral care applications

Applicant/Assignee: NOVAN, INC

Application No.: 12/580418   Filing Date: 16/Oct/2009

Abstract:The present invention provides an oral care composition Comprising a nitric oxide releasing particle and an orally-acceptable carrier. The nitric oxide releasing particle comprises at least one nitric oxide donor. Another aspect of the present invention provides a device for oral care comprising a nitric oxide releasing particle, wherein the device is configured to expose a targeted site in an oral cavity of a subject to nitric oxide. The present invention also provides methods and uses of providing oral health benefits by using the oral care compositions or devices as described above.

Priority: US20080105951P Applic. Date: 2008-10-16

Inventor: STASKO NATHAN [US]

Title: Methods for delivery of medication using dissolvable devices

Applicant/Assignee:

Application No.: 12/587985   Filing Date: 16/Oct/2009

Abstract:A method utilizing a dissolvable device for the internal delivery of medication and more particularly to the use of films, fibers or non-woven fabrics made of a safe polymer material incorporating a medication that is released by dissolution of the films, fibers or non-woven fabrics over time, and more particularly a treatment method for controlling or regulating the pH in the vagina by stabilizing and adjusting the pH in the vagina by minimizing the impact of the vaginal flora.

Priority: US2008-287253 Applic. Date: 2008-10-08; US20070998383P Applic. Date: 2007-10-11

Inventor: STAAB ROBERT J [US]

Title: COMPOSITION COMPRISING CRUSTACEAN GASTROLITH COMPONENTS AND ITS USE

Applicant/Assignee: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY

Application No.: 12/443987   Filing Date: 07/Oct/2007

Abstract:Provided is a formulation containing amorphous or microcrystalline calcium carbonate finely interspersed with organic matter in a ratio of 10 parts of the carbonate per 1 to 3 parts of the organic matter, wherein the organic matter consists of chitin and polypeptide. The formulation is efficient in treating various pathological conditions, including proliferative diseases, neurological disorders, and musculoskeletal disorders.

Priority: IL20060178495 Applic. Date: 2006-10-05; WO2007IL01211 Applic. Date: 2007-10-07

Inventor: BEN YOSSI [IL]; SAGI AMIR [IL]

Title: COMPOSITION FOR TREATING XEROSTOMIA OR DRY MOUTH

Applicant/Assignee:

Application No.: 12/527753   Filing Date: 22/Feb/2008

Abstract:The present invention provides a composition comprising olive oil, trimethylglycine and xylitol for treating xerostomia and disorders associated thereto, with very good results in increasing the unstimulated salivary flow, in alleviating the symptoms of xerostomia, including the pain associated to xerostomia, as well as improving the quality of life of affected persons. The composition of the invention has also been proved to protect dentin against demineralization in acid conditions.

Priority: ES20070000464 Applic. Date: 2007-02-22; WO2008ES00100 Applic. Date: 2008-02-22

Inventor: RODRIGUEZ-VILABOA DEBORA [ES]

Title: SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS

Applicant/Assignee: XENON PHARMACEUTICALS INC

Application No.: 12/577799   Filing Date: 13/Oct/2009

Abstract:This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof

or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Priority: US20080106410P Applic. Date: 2008-10-17

Inventor: CHAFEEV MIKHAIL [CA]; CHOWDHURY SULTAN [CA]; FRASER LAUREN [CA]; FU JIANMIN [CA]; LANGILLE JONATHAN [US]; LIU SHIFENG [CA]; SUN JIANYU [US]; SUN SHAOYI [CA]; SVIRIDOV SERGUEI [CA]; WOOD MARK [CA]; ZENOVA ALLA [CA]

Title: Regenerative wound healing using copper-silver citrate composition

Applicant/Assignee: MI HOPE INC

Application No.: 12/288749   Filing Date: 22/Oct/2008

Abstract:A composition containing copper and silver ions electrolytically generated in a solution of citric acid that also contains potassium carbonate is shown to expedite the healing of wounds with regeneration of normal tissue architecture and without excessive scarring. A wide range of wounds and other forms of tissue damage affecting the skin and other areas of the body respond favorably to the direct application of the composition, with expedited healing, re-growth of normal appearing (non-scar) tissue and symptomatic relief from pain and swelling. The composition acts in both humans and animals through a novel mechanism provisionally termed the tissue regeneration induced pathway (TRIP).

Priority:

Inventor: MARTIN WILLIAM JOHN [US]; PALMER STEPHEN BENET [US]

Title: RECOMBINANT PROTEIN COMPRISING STARCH BINDING DOMAIN AND USE THEREOF

Applicant/Assignee: SIMPSON BIOTECH CO., LTD

Application No.: 12/643304   Filing Date: 21/Dec/2009

Abstract:A recombinant protein is prepared comprising a polypeptide of interest and a starch binding domain (SBD). The said SBD is obtainable from glucoamylase of fungi genus Rhizopus. The said recombinant protein comprising the said SBD can be purified by contacting with an affinity matrix such as starch, the SBD binds to the affinity matrix to isolate the recombinant protein. The recombinant protein can be purified by separating the association between the SBD and the affinity matrix by acid, alkaline, salt, or sugar. The polypeptide of interest may be an antibody, an antigen, a therapeutic compound, an enzyme, or a protein and may apply in pathogen destruction, vaccine producing, and oral care product manufacturing. The SBD further provides as a tool to screen or identify polysacchrides.

Priority: US2005-070271 Applic. Date: 2005-03-03

Inventor: CHANG MARGARET DAH-TSYR [TW]; SHEU CHIA-CHIN [TW]

Title: One-pack type dental adhesive composition

Applicant/Assignee: KABUSHIKI KAISHA SHOFU

Application No.: 12/585974   Filing Date: 30/Sep/2009

Abstract:Disclosed is a one-pack type dental adhesive composition comprising: (a) 1.0 to 40.0 parts by weight of a silane coupling agent, (b) 0.01 to 0.4 part by weight of a weak acidic compound which is at least one of organic acid, boric acid and silicic acid, and has an acid dissociation exponent pKa of 3 or more in the form of an aqueous solution, (c) 0.01 to 0.4 part by weight of a strong acidic compound which is at least one of HF, HCl, HBr, HI, HNO3, HClO3, HClO4, HBrO4, HMnO4, H2SO4 and H3PO4 and has an acid dissociation exponent pKa of less than 3, (d) 0.1 to 5.0 part by weight of water, and (e) 20.0 to 99.0 parts by weight of a volatile organic solvent.

Priority: JP20080272887 Applic. Date: 2008-10-23

Inventor: TANAKA HISAKI [JP]; FUJII TOSHIHIDE [JP]; YAMAGUCHI YUTAKA [JP]; DEGUCHI MIKITO [JP]

Title: USE OF ALPHA-HYDROXY CARBONYL COMPOUNDS AS REDUCING AGENTS

Applicant/Assignee:

Application No.: 12/159363   Filing Date: 29/Dec/2006

Abstract:There is provided the use as reducing agents of alpha-hydroxycarbonyl compounds capable of forming cyclic dimers. There is also provided corresponding methods of reducing reducible compounds, particularly reduction-activated prodrugs. Examples of the alpha-hydroxycarbonyl compounds used are dihydroxyacetone, glycolaldehyde, glyceraldehyde, erythrose, xylulose, erythrulose or 3-hydroxy-2-butanone.

Priority: GB20050026552 Applic. Date: 2005-12-29; WO2006GB04947 Applic. Date: 2006-12-29

Inventor: KNOX RICHARD J [GB]

Title: PLACENTAL TISSUE GRAFTS AND IMPROVED METHODS OF PREPARING AND USING THE SAME

Applicant/Assignee:

Application No.: 12/428908   Filing Date: 23/Apr/2009

Abstract:Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

Priority: US2008-206508 Applic. Date: 2008-09-08; US20070989299P Applic. Date: 2007-11-20; US20070986665P Applic. Date: 2007-11-09; US20070970780P Applic. Date: 2007-09-07

Inventor: DANIEL JOHN [US]; TOFE ROBERT [US]; SPENCER RANDALL [US]; RUSSO JOHN [US]

Title: Use of advanced nanomaterials for increasing sepecific cell functions

Applicant/Assignee: UNIVERSITY OF ARKANSAS

Application No.: 12/588679   Filing Date: 23/Oct/2009

Abstract:Disclosed herein are methodologies and compositions for enhancing cellular functions, which can be used in a variety of biological applications.

Priority: US20080197424P Applic. Date: 2008-10-27

Inventor: BIRIS ALEXANDRU S [US]; MAHMOOD MEENA [US]; JENSEN PEDER [US]

Title: ALPHA-HYDROXYKETONES

Applicant/Assignee:

Application No.: 12/593025   Filing Date: 25/Mar/2008

Abstract:Compounds of the Formula (I) wherein x is an integer from 1-4

p is an integer from 1-3

q is an integer from 0-3

Ar is phenyl, naphthyl, anthryl or phenanthryl each of which optionally is substituted by one or more Cl, CN, OR5, C3-C5alkenyl or C1-C6alkyl which optionally is substituted by one or more OR6, COOR or halogen

R1 if x is 1, is ORS, O-X+, NR8R9, C1-C20alkyl optionally substituted by one or more COOR10, or is C2-C20alkyl interrupted by one ore more O, or is C2-C5alkenyl or phenyl-C1-C4alkyl

R1 if x is 2, is for example C1-C20alkylene

R1 if x is 3, is for example a tri-valent radical

R1if x is 4, is for example a tetravalent radical

R2and R3are hydrogen or C1-C8alkyl, or R2and R3 together are O, C1-C3alkylene or CH-CH

R4 is C1-C4alkyl

R5, R6, R7, R8, R9 and R10 are for example hydrogen or C1-C4alkyl

and X is a x-valent cationic counter ion

are in particular suitable as photoinitiators for the curing with UV-A light (320-450 nm).

Priority: EP20070105642 Applic. Date: 2007-04-04; WO2008EP53458 Applic. Date: 2008-03-25

Inventor: DIETLIKER KURT [CH]; MURER PETER [CH]; HUESLER RINALDO [CH]; JUNG TUNJA [DE]

Title: Plate element for the manufacture of a dental prosthesis

Applicant/Assignee:

Application No.: 12/603997   Filing Date: 22/Oct/2009

Abstract:The curved plate is used to position and model a malleable material capable of temporarily supporting the incisor and pinless teeth according to positions and orientations that will then be fixed permanently in the prosthesis. The plate has a general U shape, delimited by two parabola-shaped contours: an outer edge and an inner edge, respectively corresponding to the contour of the vestibular walls of the incisor and pinless teeth of the prosthesis to be built. The plate features a flat surface on its lower face, and an appendix defining a visible reference point that must correspond to the position of the interincisive papilla. The distance between the reference point and an average central point of the outer edge indicating a position situated between the more vestibular walls of the upper central incisor teeth, is between 8 and 10 mm.

Priority: IT2008TO00780 Applic. Date: 2008-10-23

Inventor: PRETI GIULIO [IT]; BASSI FRANCESCO [IT]; GASSINO GIANFRANCO [IT]; NOTARO VINCENZO [IT]; GENTILE FRANCESCO [IT]

Title: Non-Natural Recombinant Gelatins with Enhanced Functionality

Applicant/Assignee:

Application No.: 12/528044   Filing Date: 21/Feb/2008

Abstract:The invention concerns recombinant gelatin monomers and recombinant gelatins comprising or consisting of multimers of the monomers. The recombinant gelatins can be produced with enhanced stability.

Priority: EP20070102839 Applic. Date: 2007-02-21; EP20070102838 Applic. Date: 2007-02-21; EP20070116189 Applic. Date: 2007-09-12; EP20070116193 Applic. Date: 2007-09-12; EP20080100556 Applic. Date: 2008-01-16; WO2008NL50104 Applic. Date: 2008-02-21

Inventor: DE BOER ARJO LYSANDER [NL]; VAN URK HENDRIK [NL]; BOUWSTRA JAN BASTIAAN [NL]; VAN ASTEN PETER FRANCISCUS THE [NL]

Title: O-SUBSTITUTED-DIBENZYL UREA-DERIVATIVES AS TRPV1 RECEPTOR ANTAGONISTS

Applicant/Assignee: PHARMESTE S.R.L

Application No.: 12/519753   Filing Date: 06/Dec/2007

Abstract:The invention relates to compounds of formula (I) in which R is selected from halogen, alkyl, alkoxy, aryl and heteroaryl

R1 is selected from 2-hydroxyethyl, 2,3-dihydroxypropyl, 3-hydroxypropyl, 2,2-dihydroxyethyl, 3,3-dihydroxypropyl, 1,3-dioxolane-ethyl, 1,3-dioxane-methyl, 1,3-dioxolane-methyl, 1,3-dioxane-ethyl, 3-fluoro-2-hydroxypropyl, 3-car-boxy-2-hydroxy-propyl, 3-chloro-2-hydroxypropyl, 2-hydroxypropyl, 2-hydroxy-propen-2-yl, morpholinoethyl, piperazinoethyl, hydroxymethyl, benzyl, 4-(hydroxymethyl)benzyl, 4-chlorobenzyl, 4-fluorobenzyl, and 4-hydroxybenzyl. R2 is te/t-butyl or trifluoromethyl

R3 is independently selected from hydrogen, carboxy, cyano, alkyl or hydroxyalkyl, The compounds of formula (I) can be used for the preparation of pharmaceutical compositions for the therapy of inflammatory states, such as chronic neuropathic pain, over-active bladder syndrome, tumor pain, haemorrhoids, inflammatory hyperalgesia, post-intervention pain, dental extraction, airway and gastro-intestinal diseases.

Priority: EP20060026533 Applic. Date: 2006-12-21; WO2007IB03784 Applic. Date: 2007-12-06

Inventor: BARALDI PIER GIOVANNI [IT]; BOREA PIER ANDREA [IT]; GEPPETTI PIERANGELO [IT]; FRUTTAROLO FRANCESCA [IT]; PAVANI MARIA GIOVANNA [IT]; TREVISANI MARCELLO [IT]

Title: CURABLE COMPOSITION FOR DENTAL PURPOSES

Applicant/Assignee: KURARAY MEDICAL INC

Application No.: 12/525323   Filing Date: 24/Jan/2008

Abstract:A curable composition for dental use, containing a polymerizable monomer, inorganic particles (A) having irregular shapes and an average particle size of from 1.0 to 5.0 [mu]m, wherein the inorganic particles (A) are surface-treated with a silane coupling agent (a) represented by the formula (I): wherein R1 is a hydrogen atom or a methyl group, R2 is a hydrolyzable group, R3 is a hydrocarbon group having 1 to 6 carbon atoms, X is an oxygen or sulfur atom, p is 2 or 3, and q is an integer of from 8 to 13, and inorganic particles (B) having irregular shapes and/or spherical or nearly spherical shapes, and an average particle size of from 0.01 to 0.10 [mu]m, wherein the inorganic particles (B) are surface-treated with a silane coupling agent (b) represented in the same manner as in the silane coupling agent (a) except that q in the formula (I) is an integer of from 1 to 6, wherein the inorganic particles (A) and the inorganic particles (B) are contained in amounts of from 85 to 98% by weight and from 2 to 15% by weight, respectively, of the entire amount of the inorganic particles. The curable composition for dental use of the present invention can be suitably used as a material capable of substituting a part or all of a natural tooth in the field of dental therapy.

Priority: JP20070023538 Applic. Date: 2007-02-01; WO2008JP51003 Applic. Date: 2008-01-24

Inventor: KUBOE YOSHIKO [JP]; SEKIGUCHI TAKAHIRO [JP]

Title: Eating utensil incorporating dental flosser

Applicant/Assignee:

Application No.: 12/231274   Filing Date: 02/Sep/2008

Abstract:An eating utensil such as a disposable plastic fork, spoon or knife, or combination thereof, is combined with a dental cleaning device such as a toothpick and/or a dental flosser for personal use after eating in a location where dental hygiene items may not be otherwise available. In some embodiments the dental cleaning device may be permanently attached to the eating utensil, which can serve as a handle for using the dental cleaning device

in other embodiments the dental cleaning device may be removed in a snap-off manner for convenient deployment independent of the eating utensil, optionally configured with a thumb-finger tab.

Priority: US20080133106P Applic. Date: 2008-06-25

Inventor: CRISP JACKSON L [US]

Title: Eating utensil incorporating oral cleaning facility

Applicant/Assignee:

Application No.: 12/592653   Filing Date: 01/Dec/2009

Abstract:An eating utensil such as a disposable plastic fork, spoon, knife, or combination thereof, is combined with at least one oral cleaning device such as a toothpick, interdental pick, brush, tongue cleaner and/or a dental flosser for personal use after eating in a location where oral cleaning facilities may not be otherwise available. In some embodiments the oral cleaning device may be permanently attached to the eating utensil, which can serve as a handle for using the oral cleaning device. In other embodiments the oral cleaning device may be displaced in a snap-off or bend-away manner at score lines to expose the oral cleaning device for use, either still attached to the utensil or removed for separate use, optionally configured with a thumb-finger grip tab.

Priority: US2008-231274 Applic. Date: 2008-09-02; US20080133106P Applic. Date: 2008-06-25

Inventor: CRISP JACKSON L [US]

Title: Orally Therapeutic Plastics and Devices Formed Therefrom

Applicant/Assignee: CAO GROUP, INC

Application No.: 12/684956   Filing Date: 10/Jan/2010

Abstract:The present invention provides methods whereby a thermally formable plastic is compounded with releasable active ingredients. The compounded plastic is then formed into a desired dental delivery device such as an anatomical membrane, tray or strip. The dental device is then placed in the oral environment where it will release or leach active ingredients. The dental device is intended to treat, alter, improve, or aid in various conditions that are often present in the oral environment.

Priority: US2006-381320 Applic. Date: 2006-05-02; US20050686336P Applic. Date: 2005-06-01

Inventor: JENSEN STEVEN D [US]

Title: SACCHARIDE FOAMABLE COMPOSITIONS

Applicant/Assignee: FOAMIX LTD

Application No.: 12/646322   Filing Date: 23/Dec/2009

Abstract:A foamable composition, containing a saccharide for use in the treatment of various disorders including: water, a saccharide, about 0.2% to about 5% by weight of a surface-active agent, about 0.01% to about 5% by weight of at least one polymeric agent selected from a bio-adhesive agent, a gelling agent, a film forming agent and a phase change agent, and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.

Priority: US2006-430437 Applic. Date: 2006-05-09; US20050679020P Applic. Date: 2005-05-09; US20060784793P Applic. Date: 2006-03-21

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; BESONOV ALEX [IL]

Title: NOVEL 1,3-OXATHIANE COMPOUNDS AND THEIR USE IN FLAVOR AND FRAGRANCE COMPOSITIONS

Applicant/Assignee:

Application No.: 12/261538   Filing Date: 30/Oct/2008

Abstract:The present invention relates to novel 1,3-oxathiane compounds represented by Formula I: wherein R is selected from the group consisting of ethyl, butyl, propyl, and (methylthio)ethyl, and their uses to enhance a flavor or fragrance composition.

Priority:

Inventor: CHEN ZHEN [US]; DEWIS MARK L [US]; MERRITT DEBRA [US]

Title: VOLUME MAINTAINING OSTEOINDUCTIVE/OSTEOCONDUCTIVE COMPOSITIONS

Applicant/Assignee:

Application No.: 12/548029   Filing Date: 26/Aug/2009

Abstract:An osteoinductive/osteoconductive composition prepared from a quantity, of demineralized fibrous bone elements possessing an average surface area to volume ratio of about 100:1 to about 20:1, a quantity of mostly shaped regular non-fibrous bone elements possessing an average surface area to volume ratio of about 10:1 or less and a sufficient quantity of biocompatible fluid carrier sufficient to provide the composition as a deformable mass is provided herein. Also provided is a method of using the composition to repair a bone defect site.

Priority: US2005-284539 Applic. Date: 2005-11-22; US2003-413324 Applic. Date: 2003-04-14; WO2000US28462 Applic. Date: 2000-10-13; US19990159774P Applic. Date: 1999-10-15

Inventor: SCARBOROUGH NELSON L [US]; GADALETA SERGIO J [US]; KAES DAVID [US]; MANRIQUE ALBERT [US]

Title: Orally administered agent and an orally administered agent/supporting substrate complex

Applicant/Assignee: LINTEC CORPORATION

Application No.: 12/591700   Filing Date: 30/Nov/2009

Abstract:With an object of providing an orally administered agent (in particular a film-shaped orally administered agent) with which the ease and safety of taking the agent are improved, to attain this object, in an orally administered agent 1b having one drug-containing layer 11 and two water-swellable gel-forming layers 12, the water-swellable gel-forming layers 12 are provided, either directly or via intermediate layers, on the both faces of the drug-containing layer 11.

Priority: JP20010125804 Applic. Date: 2001-04-24; JP20040106854 Applic. Date: 2004-03-31; US2003-690811 Applic. Date: 2003-10-23; WO2002JP03920 Applic. Date: 2002-04-19; US2006-540952 Applic. Date: 2006-10-02; WO2005JP04569 Applic. Date: 2005-03-15

Inventor: NOGAMI EIJI [JP]

Title: Dosage Form For Insertion Into The Mouth

Applicant/Assignee:

Application No.: 12/608445   Filing Date: 29/Oct/2009

Abstract:Oral dosage forms as a biodegradable, water soluble film for delivering pharmaceutically active agents, particularly anti-migraine agents to patients through insertion into the mouth of patient and methods for administering pharmaceutically active agents to patients by insertion into the mouth to provide selective uptake of said agents through the mucosa and thus avoiding the gastrointestinal tract.

Priority: US20080110775P Applic. Date: 2008-11-03

Inventor: RYOO JE PHIL [US]; CHU CHUN KWONG [HK]; WANG ZHENG [US]

Title: INFILTRATION GLASS CONTAINING NIOBIUM

Applicant/Assignee:

Application No.: 12/532279   Filing Date: 18/Mar/2008

Abstract:The present invention relates to an all-ceramic dental prosthesis in which a porous ceramic matrix material is infiltrated with a glass, having a solubility of <1100 [mu]g/cm2 according to DIN EN ISO 6872. The invention also relates to the use of niobium-containing glass having an Nb2O5 content of more than 0.1% by weight as an infiltration glass for all-ceramic dental compositions.

Priority: EP20070104702 Applic. Date: 2007-03-22; WO2008EP53247 Applic. Date: 2008-03-18

Inventor: STEPHAN MARC [DE]; DURSCHANG BERNHARD [DE]

Title: METHOD AND APPARATUS FOR BLEACHING TEETH

Applicant/Assignee:

Application No.: 12/685931   Filing Date: 12/Jan/2010

Abstract:A method and apparatus for whitening teeth which allow the user to undergo dental bleaching with the mouth closed and without protruding instruments, trays or electrical wires and the like. The apparatus includes a support structure and a dental whitening composition in contact with the support structure. A light source is included in the apparatus, disposed on or in the support structure so that light emitted from the source contacts on the dental whitening composition. The apparatus has a volume ranging between 0.5-450 cm3 permitting the apparatus to fit entirely within the mouth of a user during treatment.

Priority: US2002-309831 Applic. Date: 2002-12-04

Inventor: WASYLUCHA BRYAN [US]

Title: ARTICLE AND METHOD FOR CONTROLLING ORAL-ORIGINATED SYSTEMIC DISEASE

Applicant/Assignee:

Application No.: 12/264765   Filing Date: 04/Nov/2008

Abstract:Systems and methods for treating gingival tissue or oral biofilm includes applying to the gingival tissue (sulcus or periodontal pocket) a biofilm penetrating antimicrobial agent

removing the imbedded anaerobic bacteria from the gingival tissue following at least one applying of the antimicrobial agent to the gingival tissue

administering colloidal hydrogen peroxide gel to the gingival tissue following the removing of imbedded anaerobic bacteria

and cleaning the gingival tissue with a cleaning agent directly following the administering of the colloidal hydrogen peroxide gel for modifying the environment from anaerobic (diseased) to aerobic (healthy).

Priority:

Inventor: KELLER DUANE C [US]

Title: THIAZOLIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

Applicant/Assignee:

Application No.: 12/593095   Filing Date: 25/Mar/2008

Abstract:The invention relates to novel thiazolidine derivatives of the formula (I) wherein A and R1 are as described in the description and their use as medicaments, especially as orexin receptor antagonists.

Priority: WO2007IB51048 Applic. Date: 2007-03-26; WO2008IB50620 Applic. Date: 2008-02-21; WO2008IB51110 Applic. Date: 2008-03-25

Inventor: AISSAOUI HAMED [FR]; BOSS CHRISTOPH [CH]; GUDE MARKUS [CH]; KOBERSTEIN RALF [DE]; SIFFERLEN THIERRY [FR]

Title: Device and Method for Processing or Treating Surfaces By Means of A Dry Ice Granulate

Applicant/Assignee:

Application No.: 12/594598   Filing Date: 07/Apr/2008

Abstract:The invention relates to an apparatus for surface processing or surface treatment by means of dry ice granulate, with a reservoir for receiving a dry ice medium, in particular dry ice pellets, an inlet for the feed of a propellant medium, an outlet for the supply of a mixture of propellant medium and dry ice granulate to a blast gun, and an outflow chamber lying therebetween, there being arranged in the path between the reservoir and the outflow chamber a grinding mechanism, which is formed so as to comminute the dry ice medium to dry ice granulate with a particle size in a prescribed range, and a transport roll (4) being arranged between the grinding mechanism (3) and the outflow chamber (59), the transport roll (4) being operable with a variable speed so as to vary the quantity of the particles of the dry ice granulate per unit time. Furthermore, the invention relates to a corresponding method and the use of the method.

Priority: EP20070105772 Applic. Date: 2007-04-05; WO2008EP54151 Applic. Date: 2008-04-07

Inventor: RAEDER NIELS [DE]; ROTSTEIN ROSA [DE]

Title: CURATIVES FOR EPOXY ADHESIVE COMPOSITIONS

Applicant/Assignee: DESIGNER MOLECULES, INC

Application No.: 12/595505   Filing Date: 09/Apr/2008

Abstract:The invention provides epoxy and oxetane compositions including the novel acyloxy and N-acyl curing agents described herein. Use of invention curing agents result in cured adhesive compositions with remarkably increased adhesion and reduced hydrophilicity when compared to resins cured with other types of curing agents. Furthermore, the curatives of this invention do not interfere with free-radical cure and are thus suited for use in hybrid cure thermoset compositions.

Priority: US20070922412P Applic. Date: 2007-04-09; US20070930166P Applic. Date: 2007-05-15; WO2008US59804 Applic. Date: 2008-04-09

Inventor: DERSHEM STEPHEN M [US]

Title: TOBACCO PRODUCTS AND PROCESSES

Applicant/Assignee:

Application No.: 12/267061   Filing Date: 07/Nov/2008

Abstract:A tobacco product incorporates at least one anthocyanin compound or derivative thereof. Anthocyanin compounds can be incorporated into the filter element or other components of a mouth end piece of a cigarette. The tobacco product also can have a smokeless form, and can be a smokeless tobacco product characterized as "snus

" and within that smokeless tobacco composition or formulation is incorporated anthocyanin compounds. Tobacco in green or yellow form can be cured by first placing that tobacco in intimate contact with at least one sugar and/or salt, and subjecting that tobacco to curing conditions.

Priority:

Inventor: MARSHALL JERRY WAYNE [US]; ADAMS SUSAN MARLENE [US]; LAWSON DARLENE MADELINE [US]; DUBE MICHAEL FRANCIS [US]

Title: System and apparatus for dental hygiene

Applicant/Assignee:

Application No.: 12/291444   Filing Date: 10/Nov/2008

Abstract:A method to clean the interproximal mesial and distal surfaces of a pair of adjacent teeth, as well as to clean the outer surfaces of the teeth.

Priority:

Inventor: COHEN YANEAV [US]

Title: HIGH NOBLE DENTAL ALLOY

Applicant/Assignee:

Application No.: 12/617381   Filing Date: 12/Nov/2009

Abstract:A silver free high noble dental alloy comprising at least 60 wt. % noble materials, where 40 wt. % of the material is gold

at least 2.5 wt. % gallium, at least about from 2 to 4 wt. % cobalt

and at least from about 0.01 to 0.25 wt. % lithium and/or boron

and a principal balance of palladium is provided. Dental products and methods of manufacturing dental products using such a high noble dental alloys are also provided.

Priority: US20080113917P Applic. Date: 2008-11-12

Inventor: PRASAD ARUN [US]; CASCONE PAUL J [US]

Title: Method and device for activating stem cells

Applicant/Assignee: SYNTHES USA, LLC

Application No.: 12/589956   Filing Date: 30/Oct/2009

Abstract:Invention embodiments described herein include methods and devices for stimulating mesenchymal stem cells in a stem cell source to differentiate into osteoblasts capable of forming bone. Devices and methods described include exposing a stem cell source, such as bone marrow aspirate, adipose tissue and/or purified allogenic stem cells, to an active agent, in a manner effective to form activated stem cells.

Priority: US20090152335P Applic. Date: 2009-02-13; US20080110096P Applic. Date: 2008-10-31

Inventor: HANS MEREDITH [US]; BUECHTER DOUG [US]; GRUSKIN ELLIOTT [US]; HORNSBY STEPHEN [US]; BROWN MELISSA [US]

Title: Recombinant Gelatins

Applicant/Assignee:

Application No.: 12/527900   Filing Date: 21/Feb/2008

Abstract:The invention concerns a recombinant CBE gelatin and recombinant gelatins having multimers of the CBE monomer sequence that are of particular use in several applications involving cell attachment such as in cell culture work and applications involving cell cultures of anchor dependent cells and also in a variety of medical applications.

Priority: EP20070102838 Applic. Date: 2007-02-21; EP20070102839 Applic. Date: 2007-02-21; EP20070116189 Applic. Date: 2007-09-12; EP20070116193 Applic. Date: 2007-09-12; EP20080100556 Applic. Date: 2008-01-16; WO2008NL50098 Applic. Date: 2008-02-21

Inventor: DE BOER ARJO LYSANDER [NL]; VAN URK HENDRIK [NL]; BOUWSTRA JAN BASTIAAN [NL]; VAN ASTEN PETER FRANCISCUS THE [NL]

Title: Method of Treating Residual Caries

Applicant/Assignee: CAO GROUP, INC

Application No.: 12/563223   Filing Date: 21/Sep/2009

Abstract:The present invention is a method of treating residual caries utilizing a matched laser and dye combination. After initial preparation and excavation of a caries site, a dye is flooded into the site which stains areas of residual caries. A laser with a complimentary wavelength is then used to ablate stained areas. Since healthy dental tissue will not receive the dye and allow staining, diseased tissue will be the only tissue that is stained, not only providing a visual indicator, but also providing a more efficient surface to receive laser energy and allow for more efficient ablation of the compromised tissue. According to the method, the dye may contain and enhancing, oxidizing compound or an anesthetic, and surrounding tissues may be protected by the use of substances opaque to the radiant energy. Indocyanine green has shown particular effectiveness as a dye in this and related methods.

Priority: US2007-759784 Applic. Date: 2007-06-07; US2006-423424 Applic. Date: 2006-06-09; US2009-555692 Applic. Date: 2009-09-08

Inventor: JENSEN STEVEN D [US]

Title: LAMP HOLDER

Applicant/Assignee:

Application No.: 12/689668   Filing Date: 19/Jan/2010

Abstract:A bipin fluorescent-lamp holder has a housing formed with an outwardly open housing mouth and a rotor rotatable in the housing adjacent the mouth about an axis and having a diametrally throughgoing rotor slot. The rotor is rotatable between an installation position with the rotor slot aligned with the slot and an angularly offset contact position with the slot not aligned with the mouth. The rotor and housing are so dimensioned as to receive the pins extending parallel to the axis and to move the pins in a circular orbit centered on the axis on rotation of the rotor in the housing, and contacts in the housing diametrally flanking the axis each having a main part lying outside the orbit and a contact part engageable into the orbit. The contacts pins are aligned with the slot and project into ends of the slot and into engagement with the pins only in the contact position of the rotor.

Priority: DE200710051431 Applic. Date: 2007-10-25; DE200710054930 Applic. Date: 2007-11-17; US2008-191806 Applic. Date: 2008-08-14

Inventor: VOGT KARL-WILHELM [DE]; GRESCHNER HARTMUT [DE]; NASSE MARKUS [DE]

Title: STANDARIZED BIOACTIVE HERBAL EXTRACTS

Applicant/Assignee: RANBAXY LABORATORIES LIMITED

Application No.: 12/532815   Filing Date: 24/Mar/2008

Abstract:The present invention relates to standardized extracts of Boerhaavia diffusa, wherein the extracts have anti inflammatory and analgesic activities. The present invention also includes bioassay guided fractionation of Boerhaavia diffusa leading to the identification of bioactive markers

processes for the isolation of the bioactive markers

processes for the preparation of the extracts enriched with bioactive markers from Boerhaavia diffusa

pharmaceutical compositions comprising bioactive markers, or standardized extracts of Boerhaavia diffusa and methods of standardization of the extracts.

Priority: IN2007DE00635 Applic. Date: 2007-03-23; IN2007DE01928 Applic. Date: 2007-09-11; WO2008IB51089 Applic. Date: 2008-03-24

Inventor: KATIYAR CHANDRA KANT [IN]; KANAUJIA ANIL [IN]; DUGGAR RAJEEV [IN]; YADAV SATYAPAL SINGH [IN]; SHARMA NAVIN [IN]; RAY ABHIJIT [IN]; SHIRUMALLA RAJKUMAR [IN]; BAJPAI MALINI [IN]; SHUKLA GYANESH [IN]; LAKSHMI BADDIREDDI SUBHADRA [IN]; VINAYKUMAR KONTHAM SANATHKUMAR [IN]

Title: CONFIGURABLE MULTIPURPOSE ACCESSORY KIT

Applicant/Assignee:

Application No.: 12/275140   Filing Date: 20/Nov/2008

Abstract:A configurable multipurpose accessory kit is provided. Such an accessory kit may include a central coupler, and a plurality of accessories which may be configured to meet the needs of a user. The central coupler may be a solid ring, hinged ring, split ring or linear. The accessories may then couple to the central coupler. The accessories may include an accessory coupler, and extender and a functional component. The accessory coupler may reversibly decouple from the central coupler. The extender is one of a chain, cable, string or rope. When the central coupler is a solid ring, the accessory couplers may include a clip enabled to couple and decouple from the central coupler. Where the central coupler includes a hinged ring or a split ring the accessory couplers may be solid. These accessory couplers may include a quick release for rapid removal of the accessory.

Priority:

Inventor: JANATPOUR NEDDA [US]; KUGIZAKI JENNY [US]

Title: MULTI PORTION INTRA-ORAL DOSAGE FORM AND USE THEREOF

Applicant/Assignee: MCNEIL AB

Application No.: 12/271094   Filing Date: 14/Nov/2008

Abstract:The present invention relates to a multi portion intra-oral dosage form where at least one portion is rapidly disintegrating and at least one portion is slowly disintegrating, whereby the disintegration time for the slowest disintegrating portion is at least two times longer than for the most rapidly disintegrating portion. Of certain interest is use of sensory markers/signals as conceptual aids for the subject. Also contemplated are a method and a system for delivering active agents, such as nicotine and/or metabolites thereof, such as cotinine, nicotine N'-oxide, nornicotine, (S)-nicotine-N-[beta]-glucuronide and mixtures, isomers, salts and complexes thereof as well as use and production of said formulations.

Priority:

Inventor: HUGERTH ANDREAS [SE]; LINDELL KATARINA [SE]; NICKLASSON FREDRIK [SE]; THYRESSON KRISTINA [SE]; BUNICK FRANK [US]; LUBER JOSEPH [US]

Title: SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS

Applicant/Assignee: XENON PHARMACEUTICALS INC

Application No.: 12/650196   Filing Date: 30/Dec/2009

Abstract:This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof

or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.

Priority: US2006-402310 Applic. Date: 2006-04-11; US20050670896P Applic. Date: 2005-04-11

Inventor: CHAFEEV MIKHAIL [CA]; CHAKKA NAGASREE [US]; CHOWDHURY SULTAN [CA]; FRASER ROBERT [CA]; FU JIANMIN [CA]; HOU DUANJIE [CA]; HSIEH TOM [CA]; KAMBOJ RAJENDER [CA]; LIU SHIFENG [CA]; RAINA VANDNA [IN]; BAGHERZADEH MEHRAN SEID [CA]; SUN JIANYU [US]; SUN SHAOYI [CA]; SVIRIDOV SERGUEI [CA]

Title: DEVICE FOR DENTAL AND/OR ORAL CARE AND METHOD FOR PRODUCING THE SAME

Applicant/Assignee:

Application No.: 12/597608   Filing Date: 28/Apr/2008

Abstract:The invention relates to a device for dental and/or oral care, especially a tooth brush, comprising a preferably rod-shaped tool support to which a cleaning tool, especially a bristle field, can be fastened. The tool support is configured as a composite body that comprises an enveloping body from a first material, preferably plastic material, and a functional body from a second material, preferably metal, which is embedded in the enveloping body. The dental and/or oral care device is characterized in that the functional body is configured in at least some sections thereof as a trelliswork girder frame that has longitudinal girders substantially extending in the longitudinal direction of the tool support and a plurality of cross-girders. The enveloping body is especially transparent so that the functional body is visible through the enveloping body.

Priority: DE200710019908 Applic. Date: 2007-04-27; WO2008EP03444 Applic. Date: 2008-04-28

Inventor: SCHAMBERG STEFAN [DE]; STOERKEL JENS [DE]; WINKLER TILMANN [DE]; VITT MARTIN [DE]; PFEIFER ULRICH [DE]

Title: Antimicrobial dental appliances

Applicant/Assignee: NEW MILLENNIUM ENTERPRISES, LLC

Application No.: 12/655542   Filing Date: 04/Jan/2010

Abstract:The present invention provides for a dental appliance, mouthguard and/or divers mouthpiece using an anti-microbial composition that combines the use of an elastomeric polymer composition with micronized or submicron sized particles of metal or organo/inorgano metal complexes. In addition, the use of an anti-microbial composition for use with a diver's air delivery hose to prevent breathing of contaminated air is also described.

Priority: US2006-601995 Applic. Date: 2006-11-20; US20060801653P Applic. Date: 2006-05-19

Inventor: MASON RICHARD [US]

Title: Confinement of Foam Delivered by a Proximity Head

Applicant/Assignee:

Application No.: 12/324316   Filing Date: 26/Nov/2008

Abstract:In an example embodiment, a linear wet system includes a carrier and a proximity head in a chamber. The proximity head includes three sections in a linear arrangement. The first section suctions liquid from the upper surface of a semiconductor wafer as the wafer is transported by the carrier under the proximity head. The second section is configured to cause a film (or meniscus) of cleaning foam which is a non-Newtonian fluid to flow onto the upper surface of the wafer. The third section is configured to cause a film of rinsing fluid to flow onto the upper surface of the wafer as the wafer is carried under the proximity head. The third section is defined partially around the second section and up to the first section, so that the third section and the first section create a confinement of the cleaning foam with respect to the chamber.

Priority:

Inventor: KHOLODENKO ARNOLD [US]; LIN CHENG-YU SEAN [US]; GINZBURG LEON [US]; MANDELBOYM MARK [US]; TOMASCH GREGOGRY A [US]; HUSAIN ANWAR [US]

Title: UPGRADED SINGLE-DOSE CONTAINER PARTICULARLY FOR FLUID PRODUCTS

Applicant/Assignee:

Application No.: 12/452501   Filing Date: 22/Oct/2007

Abstract:The upgraded single-dose container (1) particularly for fluid products comprises a hollow containment body (2) for a fluid product, a neck (3) that extends from the body having a dispensing mouth (4) for the product and closing means (8) that comprise a grip (9) supporting integral at least one shutter element of the dispensing mouth, a first threaded portion suitable for being associated with a second threaded portion (24) of the neck and a ring-shaped collar (11) arranged on the neck by interposing coupling means associable removable to the grip along pre-established breaking areas.

Priority: IT2007MO00239 Applic. Date: 2007-07-17; WO2007IB03163 Applic. Date: 2007-10-22

Inventor: FONTANA ANTONIO [IT]

Title: Compositions for preventing and/or treating gingivitis

Applicant/Assignee:

Application No.: 12/313678   Filing Date: 22/Nov/2008

Abstract:Compositions and methods for preventing and/or treating gingivitis which include the use of one or a plurality of TNF-[alpha] modulators.

Priority:

Inventor: SHAW JIAJIU [US]; WANG JEN CHUAN [US]; GZYBOWSKI MICHAEL S [US]

Title: EXTRACT OF TRIGONELLA FOENUM-GRAECUM

Applicant/Assignee: V-BIOTEK HOLDING APS

Application No.: 12/595715   Filing Date: 14/Apr/2008

Abstract:Disclosed herein is an extract obtainable from Trigonella foenum-graecum. In particular, the extract is obtainable by a process comprising the steps of preparing a mixture of a plant material obtained from Trigonella foenum-graecum and liquid, incubating said mixture for at least 3 hours, heating of said mixture, and recovering a liquid extract from mixture. The extract is useful in the manufacture of various types of compositions, such as pharmaceutical compositions, disinfectant or preservation agents. The pharmaceutical may be used for the treatment or prevention of an inflammatory disease or an infectious condition.

Priority: US20070911653P Applic. Date: 2007-04-13; WO2008DK50086 Applic. Date: 2008-04-14

Inventor: OLSEN JENS STEEN [DK]

Title: USE OF AN AQUEOUS GRAPE SEED EXTRACT COMBINED WITH AT LEAST ONE FLUORINE SALT TO COMBAT THE FORMATION OR ACCUMULATION OF DENTAL BIOFILM AND COMPOSITIONS COMPRISING SAID COMBINATION

Applicant/Assignee:

Application No.: 12/597114   Filing Date: 24/Apr/2008

Abstract:The invention relates to the use of an aqueous grape seed extract combined with at least one fluorine salt for the preparation of an oral hygiene composition intended to prevent and/or reduce the formation and accumulation of dental biofilm on dental surfaces or on gingival epithelial tissue.

Priority: FR20070054670 Applic. Date: 2007-04-24; WO2008EP55032 Applic. Date: 2008-04-24

Inventor: VEZIN JEAN-CLAUDE [FR]

Title: Recalcification Promoter And Composition For Oral Cavity

Applicant/Assignee: KABUSHIKI KAISHA SANGI

Application No.: 12/594230   Filing Date: 08/Apr/2008

Abstract:It is intended to provide a remineralization promoter for tooth enamel and a composition for an oral cavity, which can highly effectively promote the remineralization of tooth enamel and strongly inhibit dental caries. The remineralization promoter for tooth enamel and the composition for an oral cavity are characterized by containing amorphous hydroxyapatite and/or amorphized hydroxyapatite showing two peaks at 2[theta]=31 to 35 DEG in X-ray diffraction. The amorphized hydroxyapatite is obtained by reacting calcium salt with phosphate in an aqueous solution and drying the reaction solution at a temperature of 10 to 70 DEG C.

Priority: JP20070103135 Applic. Date: 2007-04-10; WO2008JP00909 Applic. Date: 2008-04-08

Inventor: SAKUMA SHUJI [JP]; ISHIZAKI TSUTOMU [JP]; ARAKAWA TADAYOSHI [JP]

Title: Human Growth and Differentiation Factor GDF-5

Applicant/Assignee:

Application No.: 12/374080   Filing Date: 17/Jul/2007

Abstract:This invention relates to the production and use of pharmaceutical growth factor compositions with novel characteristics, e.g. improved solubility and controlled release characteristics under physiological conditions. Said compositions of one or more precursor proteins of growth factors of the GDF family provoke morphogenic effects such as for example growth, differentiation, protection and regeneration of a variety of tissues and organs, e.g. bone, cartilage, tendons, ligaments, nerves and skin. The invention can be advantageously used for the healing of tissue-destructive injuries and for the prevention or therapy of degenerative disorders.

Priority: EP20060014928 Applic. Date: 2006-07-18; WO2007EP06331 Applic. Date: 2007-07-17

Inventor: POHL JENS [DE]; PLOEGER FRANK [DE]

Title: ANTIBODIES TO IL-6 AND USE THEREOF

Applicant/Assignee:

Application No.: 12/502581   Filing Date: 14/Jul/2009

Abstract:The present invention is directed to therapeutic methods using IL-6 antagonists such as an Ab1 antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level, reduced serum albumin level, elevated D-dimer or other cogulation cascade related protein(s), cachexia, fever, weakness and/or fatigue prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, and others.

Priority: US20080117861P Applic. Date: 2008-11-25; US20080117839P Applic. Date: 2008-11-25; US20080117811P Applic. Date: 2008-11-25

Inventor: GARCIA-MARTINEZ LEON [US]; JENSEN ANN ELISABETH CARVALHO [US]; OLSON KATIE [US]; DUTZAR BEN [US]; OJALA ETHAN [US]; KOVACEVICH BRIAN [US]; LATHAM JOHN [US]; SMITH JEFFREY T L [US]

Title: DOUBLE-EFFECTIVE VACCINE VECTOR AGAINST FOOT-AND-MOUTH DISEASE VIRUS (FMDV), METHODS OF PREPARING AND USING THE SAME

Applicant/Assignee:

Application No.: 12/577900   Filing Date: 13/Oct/2009

Abstract:A double-effective vaccine vector against foot-and-mouth disease virus having a bicistronic expression vector sequence, the bicistronic expression vector sequence is an antisense gene sequence capable of conjugating with 5' UTR of RNA of the foot-and-mouth disease virus genome and an intact sequence of VP1 structural protein gene of the foot-and-mouth disease virus. Animal experiments show that the vaccine vector provides double effects in terms of gene therapy and gene immunization for the prevention and treatment of foot-and-mouth disease in animals. Also provided are construction methods and methods of use of the vaccine vector.

Priority: CN20071103083 Applic. Date: 2007-05-28; WO2008CN00563 Applic. Date: 2008-03-21

Inventor: LIU JIXING [CN]; YANG BIN [CN]; LAN XI [CN]; YIN XIANGPING [CN]; BAI YINMEI [CN]; HAN XIAORONG [CN]; LI XUERUI [CN]; LI BAOYU [CN]; FANG YUPING [CN]; LI ZHIYONG [CN]

Title: USE OF VITAMIN B12 FOR TREATMENT OF MUCOSAL LESIONS

Applicant/Assignee:

Application No.: 12/618379   Filing Date: 13/Nov/2009

Abstract:The present invention relates to the use of the nutrition supplement known as vitamin B12 (cobalamin) to treat or prevent mucosal lesions. It relates particularly to treatment of mucosal lesions and prevention of development of recurrent mucosal lesions by the repeated administration over a period of time of vitamin B12 where a subject has normal, or above normal, serum vitamin B12 levels. Compositions (medicaments), including friendly carriers (e.g. chewing gum), and kits, for vitamin B12 delivery to mucosal lesions or other injuries are also provided.

Priority: IL20070183171 Applic. Date: 2007-05-14; WO2008IB03376 Applic. Date: 2008-05-14

Inventor: RUDOY INNA [IL]; VOLKOV ILIA [IL]; PRESS YAN [IL]

Title: FILM FORMING DENTAL COMPOSITIONS AND RELATED METHODS

Applicant/Assignee:

Application No.: 12/594988   Filing Date: 10/Jul/2008

Abstract:Film forming dental compositions are provided comprising a compound of the formula or a pharmaceutically acceptable salt thereof, and a binder.

Priority: US20070951758P Applic. Date: 2007-07-25; WO2008US69628 Applic. Date: 2008-07-10

Inventor: YANG JIE [US]; VELAMAKANNI BHASKAR V [US]; MITRA SIMITA B [US]; POCIUS ALPHONSUS V [US]; STOFKO JR JOHN J [US]; YARWOOD JEREMY M [US]

Title: SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS

Applicant/Assignee: XENON PHARMACEUTICALS INC

Application No.: 12/650218   Filing Date: 30/Dec/2009

Abstract:This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof

or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.

Priority: US2006-402310 Applic. Date: 2006-04-11; US20050670896P Applic. Date: 2005-04-11

Inventor: CHAFEEV MIKHAIL [US]; CHAKKA NAGASREE [US]; CHOWDHURY SULTAN [US]; FRASER ROBERT [US]; FU JIANMIN [CA]; HOU DUANJIE [US]; HSIEH TOM [US]; KAMBOJ RAJENDER [US]; LIU SHIFENG [CA]; RAINA VANDNA [US]; BAGHERZADEH MEHRAN SEID [US]; SUN JIANYU [US]; SUN SHAOYI [US]; SVIRIDOV SERGUEI [US]

Title: PHARMACEUTICAL PREPARATION FOR PREVENTING AND/OR TREATING PERIODONTAL DISEASE, AGENT FOR ORAL HYGIENE COMPRISING THEREOF, AND FOOD COMPRISING THEREOF

Applicant/Assignee:

Application No.: 12/275643   Filing Date: 21/Nov/2008

Abstract:The present invention provides a pharmaceutical composition for preventing and/or treating periodontal disease comprising at least one having dental root-periodontal tissue formation promotion effect selected from the group consisting of a compound shown in a following formula (I). (In the formula, R1 and R2 are independently functional groups selected from a group consisting of a substituted or non-substituted group of a linear alkyl group, a branched alkyl group, a linear alkenyl group and a branched alkenyl group with having the carbon number of 3 to 5. R'1 and R'2 are independently a hydrogen atom, hydroxyl group, or alkoxy group having the carbon number of 1 to 3.)

Priority:

Inventor: WOO JE-TAE [JP]; OHTA MASATO [JP]; YONEZAWA TAKAYUKI [JP]; TERUYA TOSHIAKI [JP]; CHA BYUNG-YOON [JP]; NAGAI KAZUO [JP]

Title: Dental adhesive composition

Applicant/Assignee:

Application No.: 12/460944   Filing Date: 27/Jul/2009

Abstract:Dental adhesive composition comprising (a) a polymerisable monomer or prepolymer, and (b) a solvent comprising t-butanol.

Priority: US2005-572613 Applic. Date: 2005-05-13; WO2005EP05263 Applic. Date: 2005-05-13; EP20040017749 Applic. Date: 2004-07-27

Inventor: BLACKWELL GORDON B [DE]

Title: Self-dental adhesive composition

Applicant/Assignee:

Application No.: 12/462609   Filing Date: 06/Aug/2009

Abstract:Self-adhesive dental restorative composition comprising (i) 10 to 40 percent by weight based on the total weight of the composition of a mixture of hydrolysis-stable polymerizable monomers of the following formula (I): wherein R is a m+n valent organic group having 1 to 20 carbon atoms and optionally 1 to 5 atoms selected from the group of nitrogen, oxygen and sulfur atoms

A independently represents a moiety of the following formula (II): wherein L is a hydrogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-14 aryl group or a group of the following formula (III) wherein R' is a hydrogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group, or a C6-14 aryl group

X is O, S, NH or NR'' wherein R'' is a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-14 aryl group

a is 0 or 1

M is a group of the following formula (IV) wherein Y is O, S, NH or NR''' wherein R''' is a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-14 aryl group

b is an integer of from O to 3

c is O or 1

d is an integer of from O to 3

provided that when b is O, then Y cannot be O

x is 0 or 1

y is 0 or 1

provided that x and y cannot be both 1, and provided that x cannot be 1 when L or a group of formula (III) is a hydrogen atom, and provided that when x is 0 then a is also 0, and provided that when y is 0 then b is greater than 0 or c is 0

B independently represents an acidic group

m is an integer of from 1 to 5

n is an integer of 0 to 3

and m+n is at least 2

(ii) 60 to 90 percent by weight based on the total weight of the composition of a filler

and (iii) an initiator system

wherein the portion of monomers of formula (I) wherein n is greater than 0 is at least 1 percent by weight based on the total weight of the mixture.

Priority: WO2008EP00916 Applic. Date: 2008-02-06; EP20070002662 Applic. Date: 2007-02-07

Inventor: KLEE JOACHIM [DE]; LEHMANN UWE [DE]; GLANER ANJA [DE]

Title: POLYMERIZABLE MONOMER, POLYMERIZABLE COMPOSITION, AND DENTAL MATERIAL

Applicant/Assignee: KURARAY MEDICAL INC

Application No.: 12/523554   Filing Date: 16/Jan/2008

Abstract:The present invention provides a polymerizable composition that exhibits excellent adhesive properties to a tooth structure (particularly dentin) when applied as a dental material, and a polymerizable monomer that is used as a component of the polymerizable composition. The present invention is a polymerizable monomer (A) that is a compound having at least two polymerizable groups. The polymerizable monomer (A) has a retention time of 7 minutes to 30 minutes in a high-performance liquid chromatography (HPLC) measurement conducted under a condition in which a column with an inner diameter of 3.9 mm and a length of 300 mm, packed with a C18 packing material having been crushed to have an average particle size of 10 [mu]m and a pore size of 125 angstroms, is used, an eluent is a mixed solvent of methanol and water contained at a ratio of 3:7, a flow rate is 1.0 mL/minute, a measurement temperature is 50 DEG C., a sample injection volume is 10 [mu]L, and a dead volume from a sample inlet to a detection point excluding the column is 87 [mu]L. The present invention also is a composition containing the polymerizable monomer (A).

Priority: JP20070008420 Applic. Date: 2007-01-17; JP20070008421 Applic. Date: 2007-01-17; JP20070073603 Applic. Date: 2007-03-20; WO2008JP50435 Applic. Date: 2008-01-16

Inventor: HINAMOTO AI [JP]; ISHINO HIROSHIGE [JP]; SEKIGUCHI TAKAHIRO [JP]; OKADA KOICHI [JP]; TAKEI MITSURU [JP]; NISHIGAKI NAOKI [JP]

Title: SYSTEM AND METHOD FOR REDUCING ENVIRONMENTAL CREMATORIAL RELEASE OF MERCURY FROM MERCURY-CONTAINING DENTAL AMALGAM

Applicant/Assignee:

Application No.: 12/625176   Filing Date: 24/Nov/2009

Abstract:The invention described herein provides for a simple, economical system and method for reducing environmental release of dental amalgamous mercury from teeth caused by cremation of corpses. The invention controls and reduces the amount of mercury released using a pre-crematorial and non-disfiguring system and method. The system of the invention can include a dental containment and applicator delivery system to apply a curable thermal protectant composition onto the teeth. The composition coating significantly inhibits the extent of thermal destruction of the tooth per se including its amalgam filling content.

Priority: US20080117277P Applic. Date: 2008-11-24; US20090174593P Applic. Date: 2009-05-01

Inventor: ARCAND BENJAMIN [US]; ROLFES BRYAN N [US]; MURDESHWAR NIKHIL M [US]; HALE JOSEPH E [US]; JOHNSON STEVEN M [US]; MITLYNG LUKE A [US]; MULLENBACH JOSEPH [US]; KAPPHAHN KRISTOPHER I [US]

Title: Oral Cavity Manipulator

Applicant/Assignee:

Application No.: 12/664391   Filing Date: 16/Jun/2008

Abstract:An oral cavity manipulator for controlling the position of tongue and jaw, the manipulator including a foundation body, maxilla and mandibular teeth engaging elements mountable on the foundation body and having width equal to or greater than the width of the foundation body and including teeth receiving portions for in use receiving the teeth of the user, a tongue position means attached to one of the foundation body, or the teeth engaging elements wherein in an operating condition the mandibular teeth engaging element is selectively located on the foundation body forward of the maxilla teeth engaging element to receive and locate the mandible of a user forward of the maxilla and position the tongue between the teeth elements to substantially maintain unobstructed airways at the throat of the user.

Priority: AU20070202799 Applic. Date: 2007-06-15; WO2008AU00846 Applic. Date: 2008-06-16

Inventor: RAZMOVSKI JOHN [AU]

Title: METHODS FOR ELECTROCHEMICAL DETECTION/QUANTIFICATION OF A NUCLEIC ACID

Applicant/Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Application No.: 12/376782   Filing Date: 08/Aug/2006

Abstract:The invention provides methods and kits for the electrochemical detection and/or quantification of a target nucleic acid molecule by means of a detection electrode. In one method there is immobilized on the detection electrode a peptide nucleic acid (PNA) capture molecule, which has a nucleotide sequence that is at least partially complementary to at least a portion of the target nucleic acid molecule. The electrode is contacted with a solution expected to include the target nucleic acid molecule and the target nucleic acid molecule allowed to hybridize to the PNA, thereby allowing the formation of a complex between the PNA capture molecule and the target nucleic acid molecule. A polymerisable positively chargeable precursor is added, which associates to the complex formed between the PNA capture molecule and the target nucleic acid molecule. A suitable reactant molecule is added, initiating the polymerisation of the polymerisable positively chargeable precursor and the formation of an electroconductive polymer. An electrochemical measurement at the detection electrode is performed. In another method a nucleic acid capture molecule is immobilized on the electrode. In this method a polymerisable positively chargeable precursor, a suitable substrate molecule, and an enzyme attached to a detection probe nucleic acid molecule are used. The detection probe nucleic acid molecule is at least partially complementary to at least a portion of the target nucleic acid molecule. The detection probe hybridizes to a portion of the target nucleic acid that is different from the portion to which the capture nucleic acid molecule hybridises.

Priority: WO2006SG00226 Applic. Date: 2006-08-08

Inventor: GAO ZHIQIANG [SG]

Title: METHOD OF FORMING A DENTAL ARTICLE

Applicant/Assignee: IVOCLAR VIVADENT AG

Application No.: 12/694710   Filing Date: 12/Feb/2010

Abstract:A method of making a dental article including a pressable body possessing a flexural strength of at least 125 MPa and flowable at about 850 DEG C. to about 950 DEG C. The body is composed of at least a glass matrix phase having a composition comprising Li2O and MgO.

Priority: US2007-785042 Applic. Date: 2007-04-13

Inventor: BRODKIN DMITRI G [US]; VERANO ANNA B [US]

Title: PROTEOLYTIC ENZYME FORMULATIONS

Applicant/Assignee:

Application No.: 12/376964   Filing Date: 09/Aug/2007

Abstract:Preferred embodiments of the present invention relate to proteolytic enzyme formulations. More specifically, several embodiments relate a proteolytic formulation comprising fungal protease, papain, bromelain, fungal pancreatin, nattokinase, protease-S, amylase, lipase, rutin, ginger, and CMIK-pH, to facilitate digestion, metabolism, degradation of target compounds, and systemic enzymatic action.

Priority: US20060836824P Applic. Date: 2006-08-10; WO2007US75630 Applic. Date: 2007-08-09

Inventor: BARRON JON [US]

Title: METHOD TO TREAT PROPOLIS

Applicant/Assignee: BALLOT-FLURIN APICULTEURS

Application No.: 12/595149   Filing Date: 23/Apr/2008

Abstract:A method to treat propolis includes conducting at least one first extraction of propolis performed on a batch of raw propolis with a first pure solvent to obtain a first extract having first properties. A second extraction may be performed with a second different pure solvent on the filtration residues obtained after the first extraction, so as to collect and make usable the entirety of the components of propolis using organic solvents only

and finally the method may include a third extraction following after the second extraction, performed on the filtration residues obtained after this second extraction, using a third pure solvent different from the two others

the first solvent then being water, the second being alcohol and the third being oil. The method applies to the production of extracts of propolis for use in the manufacture of hygiene, care, cosmetic products, food products and food supplements.

Priority: FR20070054648 Applic. Date: 2007-04-24; WO2008FR50736 Applic. Date: 2008-04-23

Inventor: BALLOT-FLURIN CATHERINE [FR]

Title: Oral Care Compositions Comprising Fused Silica

Applicant/Assignee:

Application No.: 12/625164   Filing Date: 24/Nov/2009

Abstract:An oral care composition comprising a fused silica abrasive and an orally-acceptable carrier.

Priority: US20080117856P Applic. Date: 2008-11-25

Inventor: DECKNER GEORGE ENDEL [US]; BAIG ARIF ALI [US]; HUGHES IAIN ALLAN [US]; HAUGHT JOHN CHRISTIAN [US]

Title: Prophy Paste and Weekly Oral Care Compositions

Applicant/Assignee:

Application No.: 12/625223   Filing Date: 24/Nov/2009

Abstract:An oral care composition comprising a fused silica abrasive, wherein the fused silica has a median particle size of at least about 7 microns and wherein the composition has a PCR of at least about 100.

Priority: US20080117856P Applic. Date: 2008-11-25

Inventor: HAUGHT JOHN CHRISTIAN [US]; DECKNER GEORGE ENDEL [US]; BAIG ARIF ALI [US]; HUGHES IAIN ALLAN [US]

Title: ANTIMICROBIAL AND IMMUNOSTIMULATORY SYSTEM COMPRISING AN OXIDOREDUCTASE ENZYME

Applicant/Assignee:

Application No.: 12/444231   Filing Date: 05/Oct/2007

Abstract:The present invention relates to an antimicrobial and immunostimulatory system, applications thereof and a process for the production of the antimicrobial and immunostimulatory system. The present invention provides a storage-stable antimicrobial and immunostimulatory system comprising an oxidoreductase enzyme, a substrate for the oxidoreductase enzyme and hydrogen peroxide in an aqueous solution wherein the substrate for the oxidoreductase enzyme is present up to 90% by weight and water is present up to 20% by weight based on the weight of the total composition

the system has a pH from approximately 4 to 8

and the system provides a two-stage hydrogen peroxide release.

Priority: GB20060019786 Applic. Date: 2006-10-06; WO2007IE00094 Applic. Date: 2007-10-05

Inventor: BARRETT JOHN REGINALD [IE]; BRENNAN JAMES JOSEPH [IE]; PATTON THOMAS PATRICK [IE]

Title: Mild Oral Care Compositions

Applicant/Assignee:

Application No.: 12/624680   Filing Date: 24/Nov/2009

Abstract:Oral compositions comprising fused silica, wherein the composition is essentially free of sodium lauryl sulfate.

Priority: US20080117856P Applic. Date: 2008-11-25

Inventor: HUGHES IAIN ALLAN [US]; BAIG ARIF ALI [US]; DECKNER GEORGE ENDEL [US]

Title: Mouthpiece Devices and Methods to Allow UV Whitening of Teeth

Applicant/Assignee: TWILIGHT TEETH, INC

Application No.: 12/623939   Filing Date: 23/Nov/2009

Abstract:A plastic mouthpiece insert for allowing a wearer to whiten their teeth while getting a suntan, and have a generally oblong oval-rectangular opening with a curved rear end that abuts against the root surfaces of the frontal upper and lower teeth of the wearer. A raised front edge can protect the lips and separate in place about the opening to the mouthpiece. Whitening agents can be used to enhance the whitening effect so that ultraviolet light and heat source such as the sun or a sunlamp is all that it is needed. Reflective inner walls in the mouthpiece can magnify light to the teeth. The mouthpiece can include bite tables, and the side walls of the mouthpiece can be inwardly flared and funnel shaped for focusing and magnifying incoming light and heat. The mouthpiece can be colored to protect the inside of the wearer's mouth from receiving any light. An attachable *and detachable compact hands-free light source can also be used. The light source can clip on the front of the mouthguard so that the mouthguard can allow for teeth whitening without the need for a suntanning lamp or use of the sun or other exterior light sources. The attached light source allows the user to use the mouthguard and not be restricted to staying in one place. With the attached light source the user is free to use both their hands and do all other types of activities and be able to freely move around.

Priority: US2006-603301 Applic. Date: 2006-11-21; US2003-668726 Applic. Date: 2003-09-23; US20020413049P Applic. Date: 2002-09-24

Inventor: BAUGHMAN JERALD L [US]

Title: METHOD FOR STORING SILICA-BASED MATERIAL, PACKAGE PRODUCED WITH THE METHOD AND USE OF PACKAGE FOR PACKAGING OF SILICA-BASED PRODUCTS

Applicant/Assignee:

Application No.: 12/301195   Filing Date: 23/May/2007

Abstract:A method for storing a water-soluble undissolved silica-based material, optionally with an incorporated functional agent. The method includes immersing the material in an aqueous liquid phase which is initially saturated with a water-soluble silica-based material which is the same or different than the undissolved silica-based material, such that the undissolved silica-based material does not essentially dissolve into the liquid phase during storage, or the proportion of the amount of the initially undissolved silica-based material to the amount of the liquid phase is such that the liquid phase will be saturated or essentially saturated by a dissolved portion of the water-soluble undissolved silica-based material during storage, which dissolved portion of said water soluble undissolved silica-based material is less than 20%. Also disclosed is a storage package which may preferably be used to store functional agents, delivery devices or implants.

Priority: FI20060000698 Applic. Date: 2006-07-24; US20060802506P Applic. Date: 2006-05-23; WO2007FI00136 Applic. Date: 2007-05-23

Inventor: JOKINEN MIKA [FI]; KOSKINEN MIKA [FI]; JALONEN HARRY [FI]

Title: NITROSATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE

Applicant/Assignee:

Application No.: 12/636316   Filing Date: 11/Dec/2009

Abstract:The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever

for treating gastrointestinal disorders

for facilitating wound healing

for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds

for treating inflammatory disease states and/or disorders

and for treating and/or preventing ophthalmic diseases and/or disorders.

Priority: US2005-134358 Applic. Date: 2005-05-23; US2003-612014 Applic. Date: 2003-07-03; US20020393111P Applic. Date: 2002-07-03; US20020397979P Applic. Date: 2002-07-24; US20020418353P Applic. Date: 2002-10-16; US20030449798P Applic. Date: 2003-02-26; US20030456182P Applic. Date: 2003-03-21

Inventor: EARL RICHARD A [US]; EZAWA MAIKO [US]; FANG XINQIN [US]; GARVEY DAVID S [US]; GASTON RICKY D [US]; KHANAPURE SUBHASH P [US]; LETTS L GORDON [US]; LIN CHIA-EN [US]; RANATUNGA RAMANI R [US]; RICHARDSON STEWART K [US]; SCHROEDER JOSEPH D [US]; STEVENSON CHERI A [US]; WEY SHIOW-JYI [US]

Title: SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS

Applicant/Assignee: XENON PHARMACEUTICALS INC

Application No.: 12/578148   Filing Date: 13/Oct/2009

Abstract:This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof

or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Priority: US20080106464P Applic. Date: 2008-10-17

Inventor: CHAFEEV MIKHAIL [CA]; CHOWDHURY SULTAN [CA]; FRASER LAUREN [CA]; FU JIANMIN [CA]; LANGILLE JONATHAN [US]; LIU SHIFENG [CA]; SUN JIANYU [US]; SUN SHAOYI [CA]; SVIRIDOV SERGUEI [CA]; WOOD MARK [CA]; ZENOVA ALLA [CA]; JIA QI [CA]; CADIEUX JEAN-JACQUES [CA]; GAUTHIER SIMON J [CA]; DOUGLAS AMY FRANCES [CA]; HSIEH TOM [CA]; CHAKKA NAGASREE [US]; CIKOJEVIC ZORAN [CA]

Title: INHIBITORS OF Akt ACTIVITY

Applicant/Assignee: SMITHKLINE BEECHAM CORPORATION

Application No.: 12/593415   Filing Date: 28/Mar/2008

Abstract:Invented are novel pyrazole compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.

Priority: US20070908741P Applic. Date: 2007-03-29; WO2008US58603 Applic. Date: 2008-03-28

Inventor: SEEFELD MARK ANDREW [US]

Title: DENTAL COMPOSITION BASED ON SILICONE CROSSLINKABLE BY CATION PROCESS

Applicant/Assignee: BLUESTAR SILICONES FRANCE

Application No.: 12/644347   Filing Date: 22/Dec/2009

Abstract:The invention concerns dental compositions. Said composition comprises (1) a silicone crosslinkable and/or polymerizable by cation process

(2) an efficient amount of at least an initiator such as onium borate

(3) at least a photosensitizer

and (4) a dental filler present in the composition in a proportion of at least 10 wt. % relative to the composition total weight. Said dental compositions are useful for making dental prostheses or for dental restoration.

Priority: FR19980012375 Applic. Date: 1998-10-02; US2006-604510 Applic. Date: 2006-11-27; US2004-781064 Applic. Date: 2004-02-18; US2001-806629 Applic. Date: 2001-06-25; WO1999FR02345 Applic. Date: 1999-10-01

Inventor: FRANCES JEAN-MARC [FR]

Title: CELL HANDLING DEVICE, TISSUE REGENERATION COMPOSITION, AND TISSUE REGENERATION METHOD

Applicant/Assignee:

Application No.: 12/705252   Filing Date: 12/Feb/2010

Abstract:A syringe-type cell handling device for storing and subsequently transplanting, into a living body, cells harvested from a living body or cells obtained by culturing harvested cells. The syringe-type cell handling device includes a vessel having a closed mouth and being at least partially composed of a main body, and a plunger that is slidably insertable into the main body such that the handling medium can be transplanted into a living body by applying a pushing force to the plunger. At least a part of the device that contacts the fluid handling medium, when the vessel holds the handling medium, is a gas permeable region for passing a quantity of gas necessary for survival of the cells. It is preferable that at least a part of the storage vessel inner wall in contact with the cells is formed from a cell non-adhesive material.

Priority: JP20030359935 Applic. Date: 2003-10-20; JP20030359936 Applic. Date: 2003-10-20; US2006-574816 Applic. Date: 2006-04-06; WO2003JP16397 Applic. Date: 2003-12-19

Inventor: YUGE RUI [JP]; MATSUURA YOJI [JP]; SAJIKI TOSHINOBU [JP]

Title: Tooth rag

Applicant/Assignee:

Application No.: 12/460973   Filing Date: 08/Sep/2009

Abstract:The Tooth Rag is specially designed to be used with a standard, electronic or an all wooden tooth brush handle on a circular or rectangular platform or an all disposable wooden handle. Encompassing the underside of the unit would be a tab and a strip of self affixing Velcro material with a distal end of the device serving as a platform for the tooth rag. As such, the surface of this platform would be covered in corresponding fasteners which work in tandem with the Velcro found on the underside of the cleansing cloth.

Priority: US20080189986P Applic. Date: 2008-08-25

Inventor: HASSAN LOOKMAN I [US]

Title: Novel amorphous metal salt for facilitating the handling property of portland cements and dental applications thereof

Applicant/Assignee: TAIPEI MEDICAL UNIVERSITY

Application No.: 12/591764   Filing Date: 01/Dec/2009

Abstract:A novel amorphous divalent metal ion salt for enhancing the manageability of a Portland cement and its application in dental field are disclosed. Typical formula (I), (II), or (III) of this amorphous metal ion salt are shown as following: M 2 + &#xE89E

A x - &#xE89E

B 2 - x - ( I ) M 2 + &#xE89E

A y 2 - &#xE89E

C ( 4 - y ) 4 2 - ( II ) M 2 + &#xE89E

A z 3 - &#xE89E

D ( 6 - z ) 9 3 - ( III ) wherein, M2+, A-, B-, C-2, D-3, x, y, and z are defined the same as the specification. A novel tooth filling material comprises: a Portland cement, a bone substitute substance, and an amorphous divalent metal ion salt with formula of (I), (II), or (III). In addition, a novel root canal filling material comprises: a Portland cement, a radiopaque substance, and an amorphous divalent metal ion salt with formula of (I), (II), or (III). This amorphous divalent metal ion salt in the filling material of the present invention can improve the sticking together and reduce the setting time, thus offering more convenient in dental applications.

Priority: TW20080147977 Applic. Date: 2008-12-10

Inventor: YANG JENG-CHANG [TW]; LEE PEI-YING [TW]; JI DAIN-YU [TW]; TENG NAIN-CHIA [TW]; HSIEH SUNG-CHIH [TW]; LEE SHENG-YANG [TW]

Title: INTEROCCLUSAL APPLIANCE AND METHOD

Applicant/Assignee: HAYLOFT ENTERPRISES, INC

Application No.: 12/693568   Filing Date: 26/Jan/2010

Abstract:An interocclusal appliance is formed from a single polymer material composition as one unitary piece or from multiple polymer material compositions as a two-piece preform. The two-piece preform includes a base material and an impression material that has a softening point lower than the base material. Teeth are received into the heat-softened impression material, so as to contour the impression material. A portion of the impression material also may contour to a portion of the user's palate. In certain embodiments, substantially no polymeric material contacts the front surfaces of the front teeth, leading to greater comfort and better air flow between front teeth. In still another embodiment, the appliance fits over front teeth only and no polymeric material contacts the maxillary molars.

Priority: US2007-757490 Applic. Date: 2007-06-04

Inventor: LESNIAK FRANK M [US]

Title: Electrically powered dental flossing device with sanitary and disposable floss containing unit

Applicant/Assignee:

Application No.: 12/315889   Filing Date: 08/Dec/2008

Abstract:A device for flossing teeth includes a base unit defining a handle and a disposable head unit that removeably attaches to a top end of the base unit. An electric motor in the base unit, powered by a rechargeable battery, rotates a shaft upon operation of a switch. A pair of hollow tubular arm members extend from a top of the head unit and terminate at opposing open distal ends to define a gap therebetween. A predetermined length of dental floss is partially wound on a first wheel within a clean floss chamber of the head unit and extends through the arm members and across the gap without contacting the distal ends, thereby preventing the transfer of plaque, food particles and bacteria onto exposed surfaces of the arm members. Used floss is wound onto a second floss wheel in a segregated floss collection chamber. The shaft drivingly engages a gear assembly within the head unit for rotating the first and second floss wheels, thereby controlling advanced movement of the floss in order to provide clean floss across the gap, while isolating contaminated floss within the segregated floss collection chamber.

Priority:

Inventor: COUCH VICTOR [US]

Title: THERAPEUTIC COTININE COMPOSITIONS

Applicant/Assignee: UNIVERSITY OF LOUISVILLE RESEARCH FOUBDATION

Application No.: 12/528050   Filing Date: 21/Feb/2008

Abstract:The present invention provides methods and compositions for treating acute and/or chronic inflammation with cotinine or a pharmaceutically acceptable salt thereof.

Priority: US20070890954P Applic. Date: 2007-02-21; WO2008US54569 Applic. Date: 2008-02-21

Inventor: SCOTT DAVID ALBERT [US]; MARTIN MICHAEL [US]

Title: ANTAGONISTS OF IL-6 TO PREVENT OR TREAT THROMBOSIS

Applicant/Assignee:

Application No.: 12/624830   Filing Date: 24/Nov/2009

Abstract:The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat thrombosis in diseases associated with abnormal blood coagulation or fibrinolysis. In preferred embodiments these patients will comprise those exhibiting elevated D-dimer or other coagulation cascade related proteins and optionally will further exhibit elevated C reactive protein prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, et al.

Priority: WO2008US64414 Applic. Date: 2008-05-21; WO2008US64432 Applic. Date: 2008-05-21; US2009-502581 Applic. Date: 2009-07-14; US2009-399156 Applic. Date: 2009-03-06; US2009-391717 Applic. Date: 2009-02-24; US2009-366567 Applic. Date: 2009-02-05; US20080117861P Applic. Date: 2008-11-25; US20080117839P Applic. Date: 2008-11-25; US20080117811P Applic. Date: 2008-11-25

Inventor: SMITH JEFFREY T L [US]

Title: REIMMUNIZATION AND ANTIBODY DESIGN

Applicant/Assignee:

Application No.: 12/299670   Filing Date: 12/Jan/2007

Abstract:The present invention relates to methods for harvesting of antibodies from an antibody library. The antibodies are harvested by utilising a certain epitope that is analogous to the epitope of the antigen used for immunization but that may differ in global physical and biochemical properties allowing the production of antibodies against antigens that normally can not be utilised as immunizing agents. The present invention furthermore relate to fields of use for harvested antigens in industry, agriculture and healthcare.

Priority: DK20060000054 Applic. Date: 2006-01-12; WO2007DK00018 Applic. Date: 2007-01-12

Inventor: LARSEN JANUS BEIERHOLM [DK]

Title: NEBULIZABLE COMPOSITIONS OF QUATERNARY AMMONIUM MUSCARINIC RECEPTOR ANTAGONISTS

Applicant/Assignee: DEY, L.P

Application No.: 12/704767   Filing Date: 12/Feb/2010

Abstract:Compositions and methods for treatment, prevention, or amelioration of one or more symptoms of bronchoconstrictive disorders are provided. The compositions provided herein are nebulizable compositions comprising quaternary ammonium muscarinic receptor antagonists. The compositions are suitable for direct administration to a patient in need thereof via a nebulizer. Also provided are kits which comprise of the nebulizable composition of the invention in combination with a nebulizer. Also provided is a method of treating, preventing, or amelioration of one or more symptoms of bronchoconstrictive disorders by administering a therapeutically effective amount of the nebulizable composition of the invention via the use of a nebulizer to a patient in need thereof with minimal to no exposure of the nebulizable composition to the body surface of the patient.

Priority: US2007-753648 Applic. Date: 2007-05-25; US20060803309P Applic. Date: 2006-05-26

Inventor: CHAUDRY IMTIAZ A [US]

Title: ORAL CARE PRODUCT

Applicant/Assignee:

Application No.: 12/517365   Filing Date: 23/Nov/2007

Abstract:An oral care product comprising a first composition comprising an insoluble calcium salt that is not a calcium phosphate salt, a second independent composition comprising a source of phosphate ions, and a means for delivering each of the compositions to the surface of the teeth.

Priority: WO2006CN03278 Applic. Date: 2006-12-05; WO2007EP62744 Applic. Date: 2007-11-23

Inventor: BUTLER MICHAEL FRANCIS [GB]; DENG YAN [CN]; HEPPENSTALL-BUTLER MARY [GB]; JOINER ANDREW [GB]; LI HAIYAN [FR]; LI XIAOKE [CN]

Title: Hybrid Biomimetic Particles, Methods of Making Same and Uses Therefor

Applicant/Assignee: UNIVERSITY OF TOLEDO

Application No.: 12/596221   Filing Date: 14/Apr/2008

Abstract:Biomimetic microparticles for generation of tissue includes a biodegradable tissue replacement/repair matrix formed of a cross-linked scaffold material using a non-toxic multi-valent ionic cross-linking agent. One or more bioactive materials can be encapsulated and/or coated onto the biodegradable tissue replacement/repair matrix. The biomimetic microparticles are formed without exposure to high temperatures, high pressures, high voltages, and toxic chemicals.

Priority: US20070923715P Applic. Date: 2007-04-16; WO2008US04825 Applic. Date: 2008-04-14

Inventor: JAYASURIYA A CHAMPA [US]; EBRAHEIM NABIL A [US]

Title: B-CARBOLINE FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

Applicant/Assignee: ELLNEUROXX, LTD

Application No.: 12/528771   Filing Date: 26/Feb/2008

Abstract:The embodiments relate to derivatives of 9-alkyl-[beta]-carboline, their production and pharmaceutical compositions containing these 9-alkyl-[beta]-carboline derivatives. Further, the use of 9-alkyl-[beta]-carboline derivatives and pharmaceutical compositions for the treatment and prevention of movement disorders, neurodegenerative diseases, Alzheimer's disease and Parkinson's disease is described. Additionally, these effects can be utilized for the cultivation of cells such as dopaminergic cells or stem cells which shall be engrafted for the treatment of Parkinson's disease.

Priority: DE200710009264 Applic. Date: 2007-02-26; WO2008DE00332 Applic. Date: 2008-02-26

Inventor: ROMMELSPACHER HANS [DE]

Title: PHOTO-ACTIVATED DISINFECTION

Applicant/Assignee:

Application No.: 12/443905   Filing Date: 04/Oct/2007

Abstract:Photo-activated disinfection in the oral cavity is performed by a dental apparatus which includes a handpiece having proximal and distal portions, and a handpiece cover. The distal portion of the handpiece includes light emitting elements. The handpiece cover includes a sleeve adapted to provide a cover to the proximal portion of the handpiece and a sheath adapted to provide a cover to the distal portion of the handpiece. Suitably, the sleeve is a disposable component.

Priority: GB20060019588 Applic. Date: 2006-10-04; WO2007GB50612 Applic. Date: 2007-10-04

Inventor: COLLES MICHAEL JOHN [GB]

Title: Dental cleaning device

Applicant/Assignee:

Application No.: 12/316138   Filing Date: 10/Dec/2008

Abstract:A dental cleaning device includes a mouthpiece having an arcuately shaped casing pivotally coupled to a housing and having two opposed channels formed in the casing and arranged back-to-back, and sharing a common horizontal web for receiving teeth of a user and for receiving a water, and one or more vibrating devices, such as supersonic vibrating devices are engaged into the casing for vibrating the water to clean the teeth of the user without bristles or brushes, and for preventing the teeth of the user from being scraped or scrubbed by the bristles or brushes. A container is attached to the housing for receiving and supplying the water to the mouthpiece.

Priority:

Inventor: LIN SZU TENG [TW]

Title: Natural Polypeptides For Oral Health Care

Applicant/Assignee:

Application No.: 12/523502   Filing Date: 16/Jan/2008

Abstract:The present invention relates generally to dental diseases, caries and periodontal disease. More specifically, the invention relates to Lactoferrin and Statherin fusion proteins (STAT-LF) along with therapeutic, diagnostic and research uses for these polypeptides. The present invention also provides methods of treating dental diseases, caries and periodontal disease.

Priority: US20070880753P Applic. Date: 2007-01-16; WO2008US51165 Applic. Date: 2008-01-16

Inventor: FINE DANIEL [US]; RAMASUBBU NARAYANAN [US]

Title: AZAINDOLE P2X3 AND P2X2/3 MODULATORS

Applicant/Assignee:

Application No.: 12/634031   Filing Date: 09/Dec/2009

Abstract:The application discloses compounds of the Formula I: or a pharmaceutically acceptable salt thereof, wherein, X, R1, R2 R3, R4, R5, R6, R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.

Priority: US20080201422P Applic. Date: 2008-12-09

Inventor: DILLON MICHAEL PATRICK [US]; BOIS DAISY JOE DU [US]; LAI YINGJIE [US]; HAWLEY RONALD CHARLES [US]; WANG BEIHAN [CN]

Title: KINASE INHIBITOR COMPOUNDS

Applicant/Assignee:

Application No.: 12/451833   Filing Date: 05/Jun/2008

Abstract:Pyrimidinone derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as inflammatory diseases and certain types of cancer.

Priority: US20070933385P Applic. Date: 2007-06-06; WO2008US07123 Applic. Date: 2008-06-05

Inventor: LIANG CONGXIN [US]

Title: LAYERED NON-FOULING, ANTIMICROBIAL ANTITHROMBOGENIC COATINGS

Applicant/Assignee: SEMPRUS BIOSCIENCES CORP

Application No.: 12/632669   Filing Date: 07/Dec/2009

Abstract:Substrates, optionally coated with an undercoating, having grafted thereto one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted to a variety of functionalized substrate materials, particularly polymeric substrates and/or polymeric undercoatings immobilized on a substrate. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted to a functionalized substrate, or optionally from an undercoating on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material

Priority: US20080120285P Applic. Date: 2008-12-05; US20080120292P Applic. Date: 2008-12-05; US20080120302P Applic. Date: 2008-12-05; US20090255264P Applic. Date: 2009-10-27

Inventor: ZHANG ZHENG [US]; HUVAL CHAD [US]; O'SHAUGHNESSEY WILLIAM SHANNAN [US]; HENCKE MICHAEL [US]; SQUIER TREVOR [US]; LI JUN [US]; BOUCHARD MICHAEL [US]; LOOSE CHRISTOPHER R [US]

Title: COMPUTER-ASSISTED CREATION OF A CUSTOM TOOTH SET-UP USING FACIAL ANALYSIS

Applicant/Assignee:

Application No.: 12/596231   Filing Date: 10/Apr/2008

Abstract:A method for automatic, or semi-automatic, planning of dental treatment for a patient comprises: (a) obtaining data about an area which is to be treated and data about a face of a patient

(b) performing a computer-assisted analysis of the data to determine properties of at least the face of the patient

(c) creating a modified tooth set-up using a set of stored rules which make use of the determined facial properties. A three-dimensional representation simulates the appearance of the modified tooth set-up and the patient's face surrounding the treatment area. The method also determines properties of existing teeth and creates a modified tooth set-up which is also based on the existing teeth of the patient. The method can be implemented as software running on a workstation.

Priority: GB20070007454 Applic. Date: 2007-04-18; WO2008EP03072 Applic. Date: 2008-04-10

Inventor: MALFLIET KATJA [BE]; PATTIJN VEERLE [BE]; VAN LIERDE CARL [BE]; VANCRAEN WILFRIED [BE]

Title: MOUTH CLEANING DEVICE

Applicant/Assignee:

Application No.: 12/531754   Filing Date: 18/Mar/2008

Abstract:Certain embodiments provide toothbrushes and/or other cleaning devices for contacting and cleaning teeth, gums, tongue, cheeks, and orthodontic appliance in an oral cavity. Certain embodiments provide a mouth cleaning device. The device includes a handle portion for holding and maneuvering the mouth cleaning device in an oral cavity. The device also includes a cleaning head portion including a core and a plurality of cleaning elements extending radially around the core, the core attached to the handle portion.

Priority: US20070895683P Applic. Date: 2007-03-19; US20070895669P Applic. Date: 2007-03-19; US20070911899P Applic. Date: 2007-04-15; US20070911901P Applic. Date: 2007-04-15; US20070979405P Applic. Date: 2007-10-12; US20070987409P Applic. Date: 2007-11-13; US20070987410P Applic. Date: 2007-11-13; WO2008US57363 Applic. Date: 2008-03-18

Inventor: JO HEEKYOUNG [US]

Title: Piston, Cylinder and Piston Assembly and Piston Ring for a Piston

Applicant/Assignee: MAHLE KONIG KOMMANDITGESELLSCHAFT GMBH & CO

Application No.: 12/652846   Filing Date: 06/Jan/2010

Abstract:A piston includes a piston head, two skirt walls disposed opposite one another and at least one pin bearing disposed between the skirt walls and supported on the piston head. Each skirt wall extends over a partial region of the periphery of the piston or piston head. The two skirt walls are connected by at least one self-supporting support wall disposed at a distance from the piston head. A cylinder and piston assembly and a piston ring for a cylinder, are also provided.

Priority: AT20070001049 Applic. Date: 2007-07-06; AT20070001639 Applic. Date: 2007-10-12; WO2008AT00112 Applic. Date: 2008-03-27

Inventor: LANGNER KARLHEINZ [AT]; ULRICH REINER [DE]

Title: INFANT PACIFIER FLUID DELIVERY DEVICE AND PACIFIER ASSEMBLY

Applicant/Assignee: A PLUS MEDICAL

Application No.: 12/636458   Filing Date: 11/Dec/2009

Abstract:A fluid delivery device for being secured on an infant pacifier comprises a fluid delivery nozzle configured to direct fluid toward an infant's nares and a nozzle support member secured to the fluid delivery nozzle and configured for being secured on the mouth shield of the pacifier.

Priority: US20080122234P Applic. Date: 2008-12-12

Inventor: LOESCHER THOMAS C [US]; FITZWATER DENNIS L [US]

Title: Container with Flattened Cap

Applicant/Assignee:

Application No.: 12/435918   Filing Date: 05/May/2009

Abstract:A biodegradable tube comprises a mom-rigid paper tubular body defining a lumen for containing a semi-solid composition

a paper tubular cap that slidably mates with the body

and wherein interior surfaces of the each of the body and the cap have a coating that is substantially impermeable to the semi-solid composition. In preferred embodiments the tube body and cap have tapered sealed ends, the coating comprises an adhesive, and the walls of the tube/cap comprise a rolled paper material upon which the coating has been applied. Contemplated semi-solid product materials include for example lip balm, facial cream, lotion, deodorant, sunscreen, caulk, grease sticks, mosquito repellant, and shoe polish.

Priority: US20080193689P Applic. Date: 2008-12-16

Inventor: WEST ELLERY [US]; WEST GAIL [US]

Title: Protective flood barrier system

Applicant/Assignee:

Application No.: 12/316249   Filing Date: 11/Dec/2008

Abstract:Protective flood barrier system on the base of mobile protective flood barriers is offered. Each of these barriers comprises two or more filled elongate sleeves, a web, connecting theirs web and forming means. Envelops of said sleeves and said web are made from flexible impermeable material. These barriers are convenient for protection of separate houses, the extensive areas, as walls of a water basin. They allow reducing wind-induced waves and can be used for repair of earthen dams. The high-efficiency means accelerating installation of barriers are provided.

Priority:

Inventor: FELDMAN BORIS [CA]; FELDMAN ALEXANDER [CA]; FELDMAN MICHAEL [CA]