Patent No.: US6461590B2 Issued: 2002-10-08

Title: Stabilized gas-supersaturated suspensions and methods for their delivery

Applicant/Assignee: SPEARS J. RICHARD,

Application No.: 09/866314 Applic. Date: 2001-05-25

Abstract: The present invention provides a method of delivering an emulsion or suspension containing a supersaturated gas into a gas-depleted environment. The method generally comprises the steps of preparing an emulsion or suspension, exposing the emulsion or suspension to a gas at a pressure greater than 2 bar, and delivering the emulsion or suspension to a gas-depleted environment at ambient pressure.

Priority: US1999-258758 Applic. Date: 1999- 02-26; US1997-889634 Applic. Date: 1997-07-08; US1996-730517 Applic. Date: 1996-10-11

Inventor: SPEARS J RICHARD [US]

Patent No.: US6372200B2 Issued: 2002-04-16

Title: UV-photoprotecting sunscreen compositions comprising immixture of polyethylene/carboxylated polyethylene polymers

Applicant/Assignee: JOSSO MARTIN,

Application No.: 09/771661 Applic. Date: 2001-01-30

Abstract: Topically applying cosmetic/dermatological compositions well suited for both effective and SPF-enhanced UV-photoprotection of human skin and/or hair contain (a) an effective UV-photoprotecting amount of at least one UV-A and/or UV-B sunscreen and (b) an amount of immixture of ethylene polymers effective to enhance the SPF value of said at least one UV-A and/or UV-B sunscreen (a), said immixture of ethylene polymers (b) comprising (i) at least one carboxylated polyethylene and (ii) at least one polyethylene, formulated into a topically applicable, cosmetically/dermatologically acceptable vehicle, diluent or carrier therefor, advantageously formulated as an oil-in-water emulsion.

Priority: FR20000001535 Applic. Date: 2000-02-08

Inventor: JOSSO MARTIN [FR]; MEURISSE STEPHANIE [FR]

Title: Barrier laminate with a polymeric nanocomposite oxygen barrier layer for liquid packaging

Applicant/Assignee: CURTIS JAMES F

Application No.: 09/833521 Applic. Date: 2001-04-12

Abstract: The present invention relates to an improved laminate for containers of liquid, such as juice, the laminate comprising: a paperboard substrate

an outer layer of a member selected from the group consisting of heat-sealable low density polyethylene polymers and Plexar

and an inner barrier layer of a polymeric nanocomposite blend comprising at least one resin and a layered silicate dispersed in said resin. The layered silicate preferably has a layer thickness of about 7 to 12 A and an interlayer thickness of about 30 A or greater.

Priority: US1998-144212 Applic. Date: 1998-08-31

Inventor: CURTIS JAMES F [US]

Patent No.: US6933331B2 Issued: 2005- 08-23

Title: Nanostructured fillers and carriers

Applicant/Assignee: YADAV TAPESH,

Application No.: 09/790036 Applic. Date: 2001-02-20

Abstract: A nanocomposite structure comprising a nanostructured filler or carrier intimately mixed with a matrix, and methods of making such a structure. The nanostructured filler has a domain size sufficiently small to alter an electrical, magnetic, optical, electrochemical, chemical, thermal, biomedical, or tribological property of either filler or composite by at least 20%.

Priority: US1998- 083893 Applic. Date: 1998-05-22

Inventor: YADAV TAPESH [US]; KOSTELECKY CLAYTON [US]; FRANKE EVAN [US]; MIREMADI BIJAN [US]; AU MING [US]; VIGLIOTTI ANTHONY [US]

Title: ELECTROCHEMICAL SENSOR WITH DUAL PURPOSE ELECTRODE

Applicant/Assignee: TIERNEY MICHAEL J

Application No.: 09/351762 Applic. Date: 1999-07-12

Abstract: The present invention provides an electrode assembly for use in a transdermal analyte sensor operating in an alternating polarity mode in which a single electrode element provides both the counter electrode and iontophoretic electrode functions. By combining both the functions of the iontophoretic and counter electrode, the surface area of the electrode with respect to each function may be made larger. In turn this increases the ability of the electrode to deliver the required electrical field over a larger area when operating in the iontophoretic mode as well as increasing the ability of the counter electrode to compensate for the larger sensing electrode facilitated by this new design.

Priority: US1996-653161 Applic. Date: 1996-05-24

Inventor: TIERNEY MICHAEL J [US]

Patent No.: US6682244B2 Issued: 2004-01-27

Title: Devices and methods for dispensing

Applicant/Assignee: GUERET JEAN LOUIS H,

Application No.: 09/859444 Applic. Date: 2001-05-18

Abstract: A device for dispensing comprises a reservoir containing a composition comprising particles containing at least one fluid, an application member having at least a portion removably disposed within the reservoir and configured to be loaded with the composition and a compacting member configured to exert pressure on at least the portion of the application member during removal of the portion of the application member from the reservoir.

Priority: FR20000006449 Applic. Date: 2000-05-19

Inventor: GUERET JEAN LOUIS H [FR]

Patent No.: US6690959B2 Issued: 2004- 02-10

Title: Skin-mounted electrodes with nano spikes

Applicant/Assignee: MEDTRONIC INC [US]

Application No.: 09/944821 Applic. Date: 2001-08-31

Abstract: Epidermally mountable device includes terminus structures to enable positive connection with conductive tissue. The device includes nano spikes shaped to penetrate the epidermis of the skin to collect electrical biopotentials such as cardiac depolarization waveforms (ECGs) and various signals transmitted by implanted devices. Generally, the nano spikes are integrated on a substrate comprising, preferably, a flexible metalized conductive plate attachable to an adhesive backing. The device could be mounted on any external body of the patient to collect ECG, EEG or other signals. Further, the device is adaptable to include a programmable microprocessor, including memory and an antenna to store, receive and transmit data as needed.

In one embodiment, in addition to collecting physiologic data through direct contact, the device may also be used as a smart patch to download, store and transfer data from implanted medical devices or other data sources using wireless data transmission medium.

Priority: US20000229925P Applic. Date: 2000-09-01

Inventor: THOMPSON DAVID L [US]

Title: Thermal conductive sheet with conductive foil

Applicant/Assignee: YAMAGUCHI AKIO,

Application No.: 09/923509 Applic. Date: 2001-08-06

Abstract: A thermal conductive sheet with conductive foil is obtained by press bonding a magnetic foil to a thermal conductive layer via a primer layer. Since the primer layer contains a thermal conductive filler, it has high thermal conductivity and does not interrupt thermal conduction from the thermal conductive layer to the magnetic foil. It also spontaneously destroys a skin layer on the surface of the thermal conductive layer upon the press bonding. Accordingly, the thermal conductive sheet with conductive foil of the present invention improves thermal conduction from the thermal conductive layer to the conductive foil, eliminating the unfavorable effects of the skin layer and the primer layer, and thus improves heat radiation of the thermal conductive sheet with conductive foil.

Priority: JP20000242788 Applic. Date: 2000-08-10

Inventor: YAMAGUCHI AKIO [JP]; KAWAI HIDEHARU [JP]; KAWAGUCHI YASUHIRO [JP]

Patent No.: US6692773B2 Issued: 2004-02-17

Title: Treatment of hyperproliferative skin disorders and diseases

Applicant/Assignee: BURRELL ROBERT EDWARD,

Application No.: 09/916757 Applic. Date: 2001-07-27

Abstract: The invention relates to the use of one or more noble metals selected from silver, gold, platinum, and palladium but most preferably silver, in a nanocrystalline form, for the treatment of a hyperproliferative skin disorder or disease such as psoriasis. Among the noble metals, silver is preferred for such treatment. The nanocrystalline noble metal of choice may be used in the form of a nanocrystalline coating of one or more noble metals, a nanocrystalline powder of one or more noble metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more noble metals.

Priority: US2000-628735 Applic. Date: 2000-07-27

Inventor: BURRELL ROBERT EDWARD [CA]; WRIGHT JOHN BARRYMORE [CA]; LAM KAN [CA]

Patent No.: US7273458B2 Issued: 2007-09-25

Title: ASSESSMENT AND CONTROL OF ACOUSTIC TISSUE EFFECTS

Applicant/Assignee: LIU JIN,

Application No.: 09/229226 Applic. Date: 1999-01-12

Abstract: A method for reversibly, or irreversibly, altering the permeability of cells, tissues or other biological barriers, to molecules to be transported into or through these materials, through the application of acoustic energy, is enhanced by applying the ultrasound in combination with means for monitoring and/or implementing feedback controls. The acoustic energy is applied directly or indirectly to the cells or tissue whose permeability is to be altered, at a frequency and intensity appropriate to alter the permeability to achieve the desired effect, such as the transport of endogenous or exogenous molecules and/or fluid, for drug delivery, measurement of analyte, removal of fluid, alteration of cell or tissue viability or alteration of structure of materials such as kidney or gall bladder stones.

In the preferred embodiment, the method includes measuring the strength of the acoustic field applied to the cell or tissue at the applied frequency or other frequencies, and using the acoustic measurement to modify continued or subsequent application of acoustic energy to the cell or tissue. In another preferred embodiment, the method further includes simultaneously, previously, or subsequently exposing the cell or tissue to the chemical or biological agent to be transported into or across the cell or tissue. In another preferred application, the method includes removing biological fluid or molecules from the cells or tissue simultaneously, previously or subsequently to the application of acoustic energy and, optionally, assaying the biological fluid or molecules.

Priority: US19980071240P Applic. Date: 1998-01-12; US19980085304P Applic. Date: 1998-05-13

Inventor: LIU JIN [US]; LEWIS THOMAS N [US]; PRAUSNITZ MARK R [US]

Title: Method and apparatus for attaching a microdevice or a nanodevice to a biological member

Applicant/Assignee: ERLACH JULIAN VAN,

Application No.: 09/727716 Applic. Date: 2000-11-30

Abstract: A method and apparatus for attaching a microdevice or nanodevice to a biological member is disclosed. The biological member is one of a blood cell, lipid molecules, a liver cell, a nerve cell, a skin cell, a bone cell, a lymph cell, an endocrine cell, a circulatory cell, a muscle cell. The nanodevice or microdevice includes one of a diagnostic system, a transmitter, a receiver, a battery, a transistor, a capacitor, and a detector.

Inventor: ERLACH JULIAN VAN [US]; OLSEN ARLEN L [US]; SMITH JEFFREY M [US]; SMITH LAURA B [US]; BENDER GERALD E [US]; STINCHCOMB AUDRA L [US]; DONNELLY DENIS P [US]; SCOTT MARK D [US]; PETERSON JAMES E [US]; HIRSCH ROBERT S [US]

Title: Method for inserting a microdevice or a nanodevice into a body fluid stream

Applicant/Assignee: ERLACH JULIAN VAN,

Application No.: 09/727718 Applic. Date: 2000-11-30

Abstract: A method for inserting a microdevice or nanodevice into a body fluid stream is disclosed. The micro or nanodevice may be inserted into or external to a cell, e.g., a red blood cell. For insertion into the cell, techniques such as reversible osmotic lysis, electroporation, microfine needle injection, and particle gun injection may be used. For the external device, it may be chemically modified with an organo hydroxyl, such as poly (ethylene glycol), methoxypoly (ethylene glycol). Also, it may include a lipid anchor.

Inventor: ERLACH JULIAN VAN [US]; OLSEN ARLEN L [US]; SMITH JEFFREY M [US]; SMITH LAURA B [US]; BENDER GERALD E [US]; STINCHCOMB AUDRA L [US]; DONNELLY DENIS P [US]; SCOTT MARK D [US]; PETERSON JAMES E [US]; HIRSCH ROBERT S [US]

Patent No.: US6629990B2 Issued: 2003-10-07

Title: Heat-removal method and apparatus for treatment of movement disorder episodes

Applicant/Assignee: PUTZ DAVID A,

Application No.: 09/904802 Applic. Date: 2001-07-13

Abstract: Heat-removal method and apparatus for treatment of movement disorder episodes

more specifically, a device and method for intracranially suppressing movement disorder episodes upon the detection of physiological symptoms. The device includes a temperature-contact implanted at a targeted portion in the brain which is determined to be associated with such episodes and connection to an implanted heat-transfer operator, typically a Peltier cooler or a thermal-electric cooler. Heat transfer from the temperature-contact to the heat-transfer operator cools the targeted portion and suppresses the movement disorder episode. Such heat transfer is performed upon the sensing of symptoms which normally preface episodes. The symptoms can be sensed intracranially by sensing-contacts, on the skin by a sensor or by a person or animal.

Alternatively, heat removal (cooling) can be performed without sensing symptoms to prevent episodes when the patient is particularly sensitive to, or in danger from, episodes.

Inventor: PUTZ DAVID A [US]; ZIOBRO JOHN [US]

Title: Method of induction of apoptosis and inhibition of matrix metalloproteinases using antimicrobial metals

Applicant/Assignee: BURRELL ROBERT EDWARD,

Application No.: 10/131568 Applic. Date: 2002-04-23

Abstract: The invention relates to a method to induce apoptosis and to inhibit matrix metalloproteinases in a disease condition in a human or animal by contacting hyperplastic tissue, tumor tissue, or a cancerous lesion with one or more antimicrobial metals, preferably formed with atomic disorder, and preferably in a nanocrystalline form. The nanocrystalline antimicrobial metal of choice may be used in the form of a nanocrystalline coating of one or more antimicrobial metals, a nanocrystalline powder of one or more antimicrobial metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial metals.

Priority: US2001-840637 Applic. Date: 2001-04-23; US20010285884P Applic. Date: 2001-04-23

Inventor: BURRELL ROBERT EDWARD [CA]; WRIGHT JOHN BARRYMORE [US]; LAM KAN [US]

Title: Method for removing oil, petroleum products and/or chemical, pollutants from liquid and/or gas and/or surface

Applicant/Assignee: PETRIK VIKTOR IVANOVICH

Application No.: 09/848047 Applic. Date: 2001-05-03

Abstract: The invention relates to the field of ecology, in particular to the struggle against pollution of the environment with oil, petroleum products, cyclic and aromatic hydrocarbons, other chemical pollutants, i.e. to purification of a water area, waste waters, industrial machinery, polluted soil and grounds etc., and also to the field of objects used to satisfy the vital requirements of humans and to medicine. A method for removing chemical pollutants includes preparing a carbonaceous mixture of an expanded graphite and carbonaceous nanocrystals of a graphite- containing feedstock, dispersing it onto the surface and/or into a liquid and/or placing on a surface and/or passing a liquid or gas through a filter, and collecting the carbonaceous mixture saturated with the pollutants. The method is used for collecting oil and petroleum products from the surface of water, for filtering drinking water, is used for removing volatile fractions of petroleum products or gaseous condensate from free basins of storage reservoirs, for neutralizing exhaust gases of internal combustion engines as the base of a matrix of a neutralizer of exhaust gases, for filtering cigarette smoke, for purifying blood plasma, for external use in the case of skin integument diseases characterized by discharges. The invention makes it possible to enhance the effectiveness of the removal of oil and petroleum products and also to ensure the removal of other chemical pollutants.

Priority: RU20010108456 Applic. Date: 2001-04-02

Inventor: PETRIK VIKTOR IVANOVICH [RU]

Patent No.: US6939568B2 Issued: 2005-09-06

Title: Treatment of inflammatory skin conditions

Applicant/Assignee: BURRELL ROBERT EDWARD,

Application No.: 10/131511 Applic. Date: 2002-04-23

Abstract: The invention relates to the use of one or more antimicrobial metals, most preferably silver, preferably formed with atomic disorder, and preferably in a nanocrystalline form, for the treatment of inflammatory skin conditions. The nanocrystalline antimicrobial metal of choice may be used in the form of a nanocrystalline coating of one or more antimicrobial metals, a nanocrystalline powder of one or more antimicrobial metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial metals.

Priority: US2001- 840637 Applic. Date: 2001-04-23; US20010285884P Applic. Date: 2001-04-23

Inventor: BURRELL ROBERT EDWARD [CA]; YIN HUA QING [CA]

Patent No.: US7001617B2 Issued: 2006-02-21

Title: Method of induction of apoptosis and inhibition of matrix metalloproteinases using antimicrobial metals

Applicant/Assignee: BURRELL ROBERT EDWARD,

Application No.: 10/159587 Applic. Date: 2002-05-30

Abstract: The invention relates to a method to induce apoptosis and to inhibit matrix metalloproteinases in a disease condition in a human or animal by contacting hyperplastic tissue, tumor tissue, or a cancerous lesion with one or more antimicrobial metals, preferably formed with atomic disorder, and preferably in a nanocrystalline form. In another aspect of the invention, there is provided a method of preventing excessive release of matrix metalloproteinases from an inflammatory cell in a disease condition in a human or an animal by contacting the cell with a therapeutically effective amount of a noble metal in a crystalline form characterized by atomic disorder, or with a solution derived therefrom to provide a modulatory effect on one or more matrix metalloproteinases, wherein the one or more noble metals is formed with atomic disorder, and preferably in a nanocrystalline form.

The nanocrystalline antimicrobial or noble metal of choice may be used in the form of a nanocrystalline coating of one or more antimicrobial or noble metals, a nanocrystalline powder of one or more antimicrobial or noble metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial or noble metals.

Priority: US2002-131511 Applic. Date: 2002-04-23; US2002-131509 Applic. Date: 2002-04-23; US2002-128208 Applic. Date: 2002-04-23; US2002-131568 Applic. Date: 2002-04-23; US2001- 840637 Applic. Date: 2001-04-23; US20010285884P Applic. Date: 2001-04-23

Inventor: BURRELL ROBERT EDWARD [CA]; WRIGHT JOHN BARRYMORE [US]; LAM KAN [US]

Patent No.: US6780430B2 Issued: 2004-08-24

Title: Stabilization method of nano-sized emulsion using tocopheryl derivatives and external application for skin containing the same

Applicant/Assignee: YOO BYUNG HEE,

Application No.: 10/120389 Applic. Date: 2002-04-12

Abstract: Disclosed herein is a stabilization method of nano-sized emulsion by using lecithin and tocopheryl derivatives represented by the following formula (I) and (Wherein, R1, R2 and R3 are H or methyl group, and at least one position selected from the group consisting of the R1, R2 and R3 positions are methyl group

and, A is CH2-CH(CH3)- or CH=C(CH3)-) and an external application for skin containing the stabilized nano-sized emulsion.

Priority: KR20010031360 Applic. Date: 2001-06-05

Inventor: YOO BYUNG HEE [KR]; KIM JOONG SOO [KR]; KANG BYUNG YOUNG [KR]; KIM KIL JOONG [KR]; HAN SANG HOON [KR]

Patent No.: US6989156B2 Issued: 2006-01-24

Title: Therapeutic treatments using the direct application of antimicrobial metal compositions

Applicant/Assignee: GILLIS SCOTT H,

Application No.: 10/128208 Applic. Date: 2002-04-23

Abstract: Therapeutic treatments using the direct application of selected structures of antimicrobial metals in free-standing powder form, solution form and/or suspension form in therapeutically effective amounts. The selected structures of antimicrobial metals serve as an antimicrobial agent, an anti-inflammatory agent, an immuno modulator agent, an enzyme modulator agent, and/or an anti-tumor agent, for human and/or animal use.

Priority: US2001 -840637 Applic. Date: 2001-04-23; US20010285884P Applic. Date: 2001-04-23

Inventor: GILLIS SCOTT H [US]

Patent No.: US6638918B2 Issued: 2003- 10-28

Title: Chitosan compositions

Applicant/Assignee: DAVISON GORDON ROBERT,

Application No.: 10/280617 Applic. Date: 2002-10-25

Abstract: Compositions comprising chitosan in the form of a network of nano-sized fibres. There is also provided a process for making such compositions. The compositions have improved solubility and activity. The compositions are useful in hair care, skin care, odour control, wound care, blood management, sanitary compositions, oral care, film formation, hard surface treatment, fabric treatment, release of hydrophobic or hydrophilic materials, plant care, water purification and drug delivery.

Priority: GB20010026923 Applic. Date: 2001-11-09

Inventor: DAVISON GORDON ROBERT [GB]; KONIG AXEL [BE]; GIBBONS CLYDE [GB]; RIPLEY MARK BRIAN [GB]; MACGILP NEIL ARCHIBALD [GB]; MILICH GEORGINA LYNDSEY CLAIRE [GB]; PRETSWELL EMMA LOUISE [GB]

Patent No.: US6861078B2 Issued: 2005-03-01

Title: Plant extracts with anti-radical type action

Applicant/Assignee: COGNIS FRANCE SA [FR]

Application No.: 10/307977 Applic. Date: 2002-12-03

Abstract: The use of plant extracts, especially plant extracts with an anti-radical-type action, and a cosmetic or dermopharmaceutical composition containing extracts of this type. The use of at least one plant extract whose botanical genus belongs to the group formed by the following: Clidemia, Inga, Sabicea, Astrocaryum, Siparuna, Eperua, Byrsonima, Priva, Coutoubea and Goupia genera

as an active substance which has especially anti-radical-type activities, for preparing a cosmetic or dermopharmaceutical product for local, external use for the skin, the mucous membranes and/or the epithet or appendage structures.

Priority: FR19980015380 Applic. Date: 1998-12-03; US2001- 857445 Applic. Date: 2001-06-04

Inventor: PAULY GILLES [FR]; MORETTI CHRISTIAN [FR]

Patent No.: US6733614B2 Issued: 2004-05-11

Title: Process for forming thermal conductive sheet

Applicant/Assignee: YAMAGUCHI AKIO,

Application No.: 10/358425 Applic. Date: 2003-02-04

Abstract: A thermal conductive sheet with conductive foil is obtained by press bonding a magnetic foil to a thermal conductive layer via a primer layer. Since the primer layer contains a thermal conductive filler, it has high thermal conductivity and does not interrupt thermal conduction from the thermal conductive layer to the magnetic foil. It also spontaneously destroys a skin layer on the surface of the thermal conductive layer upon the press bonding. Accordingly, the thermal conductive sheet with conductive foil of the present invention improves thermal conduction from the thermal conductive layer to the conductive foil, eliminating the unfavorable effects of the skin layer and the primer layer, and thus improves heat radiation of the thermal conductive sheet with conductive foil.

Priority: JP20000242788 Applic. Date: 2000-08-10; US2001-923509 Applic. Date: 2001-08-06

Inventor: YAMAGUCHI AKIO [JP]; KAWAI HIDEHARU [JP]; KAWAGUCHI YASUHIRO [JP]

Patent No.: US7482332B2 Issued: 2009-01-27

Title: Telomere-encoding synthetic DNA nanocircles, and their use for the elongation of telomere repeats

Applicant/Assignee: KOOL ERIC T,

Application No.: 10/336265 Applic. Date: 2003-01-03

Abstract: Telomere-encoding nucleic acid nanocircles, methods for their preparation, and methods for their use are disclosed. The nanocircles can be constructed containing multiple repeats of the complement of telomere repeat sequences. The telomere- encoding nanocircles are useful for extending telomeres both in vitro and in vivo, for treating macular degeneration, the effects of skin aging, liver degeneration, and cancer. The nanocircles are further useful for treating cell cultures to produce long-lived non-cancerous cell populations. This use has wide applicability in scientific research, tissue engineering, and transplantation.

Priority: US20020345056P Applic. Date: 2002-01-04

Inventor: KOOL ERIC T [US]

Title: Substantially visibly transparent topical physical sunscreen formulation

Applicant/Assignee: TSUZUKI TAKUYA,

Application No.: 10/324112 Applic. Date: 2002-12-20

Abstract: A topically applied sunscreen composition is provided, which by use of nano-sized particles of a physical UV screening agent in a dermatologically acceptable carrier, provides a dermatologically acceptable level of SPF and broad spectrum protection from UVA and UVB radiation, without the need to include chemical UV screening agents in the composition.

Priority: AU2002PS00808 Applic. Date: 2002-02-27

Inventor: TSUZUKI TAKUYA [AU]; NEARN MALCOLM [AU]; TROTTER GEOFF JAMES [AU]

Title: Skin treatments containing nano-sized vitamin K

Applicant/Assignee: MARCHAL ALFRED

Application No.: 10/378570 Applic. Date: 2003-03-03

Abstract: This invention relates to skin treatments containing nano-sized vitamin K. Specifically, the invention relates to a skin treatment containing nano-sized vitamin K for the use in improving the aesthetic aspects of the skin.

Priority: US20020361234P Applic. Date: 2002- 03-01

Inventor: MARCHAL ALFRED [BE]

Title: Compositions of metal-containing compounds

Applicant/Assignee: BURRELL ROBERT E,

Application No.: 10/277356 Applic. Date: 2002-10-22

Abstract: Compositions of metal-containing compounds are disclosed. Methods of preparing and using the compositions, particularly in the treatment of a subject having a condition, are also disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.

Priority: US2000-628735 Applic. Date: 2000-07-27; US2001-916757 Applic. Date: 2001-07-27; US2001-840637 Applic. Date: 2001-04-23; US2002-131509 Applic. Date: 2002-04-23; US2002-131511 Applic. Date: 2002-04-23

Inventor: BURRELL ROBERT E [CA]; GILLIS SCOTT H [US]; SCHECHTER PAUL [US]; WRIGHT JOHN B [US]; LAM KAN [US]; YIN HUA QING [CA]; NAYLOR ANTONY G [CA]; MOXHAM PETER H [CA]

Title: Nanoemulsion comprising metabolites of ginseng saponin as an active component and a method for preparing the same, and a skin-care composition for anti-aging containing the same

Applicant/Assignee: YOO BYUNG HEE,

Application No.: 10/336024 Applic. Date: 2003-01-03

Abstract: Disclosed herein is nanoemulsion prepared by emulsifying main metabolites of ginseng saponin obtained by conversion of glucose, i.e. compound K (20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol), ginsenoside F1 (20-O-beta-D-glucopyranosyl-20(S)-protopanaxatriol) and compound Y (20-O-[alpha-L-arabinopyranosyl(1 ->6)-beta-D-glucopyranosyl]-20(S)-protopanaxadiol)

and admixture thereof, in fine emulsion or liposome with dermotropic emulsifier by nano-emulsification

and having enhanced skin penetration, so to be effective in promoting proliferation of fibroblast and biosynthesis of collagen.

Priority: KR20020000613 Applic. Date: 2002-01-05; KR20020000614 Applic. Date: 2002-01-05; KR20020019032 Applic. Date: 2002-04-08; KR20020029179 Applic. Date: 2002-05-27

Inventor: YOO BYUNG HEE [KR]; KANG BYUNG YOUNG [KR]; YEOM MYEONG HOON [KR]; SUNG DAE SEOK [KR]; HAN SANG HOON [KR]; KIM HAN KON [KR]; JU HEE KYUNG [KR]

Title: Method and apparatus for preparing biomimetic scaffold

Applicant/Assignee: CAMPBELL PHIL G,

Application No.: 10/391458 Applic. Date: 2003-03-18

Abstract: Methods, compositions, and apparatus for preparing biomimetic scaffolds are provided. The methods, compositions, and apparatus are compatible with both in situ and external scaffold preparation. Also provided are methods for preparing scaffolds having 3-D spatial and/or temporal gradients of therapeutic compounds, such as, growth factors, antibiotics, immunosuppressants, analgesics, etc.

Priority: US20020365451P Applic. Date: 2002-03-18

Inventor: CAMPBELL PHIL G [US]; WEISS LEE E [US]

Patent No.: US6989157B2 Issued: 2006-01-24

Title: Dry powders of metal- containing compounds

Applicant/Assignee: GILLIS SCOTT H,

Application No.: 10/277298 Applic. Date: 2002-10-22

Abstract: Dry powders of metal-containing compounds are disclosed. Methods of preparing and using the dry powders, particularly in the treatment of a subject having a condition, are also disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.

Priority: US2000-628735 Applic. Date: 2000-07-27; US2001-916757 Applic. Date: 2001-07-27; US2001-840637 Applic. Date: 2001-04-23; US2002-128208 Applic. Date: 2002-04- 23; US2002-131509 Applic. Date: 2002-04-23; US2002-131511 Applic. Date: 2002-04-23; US2002-131568 Applic. Date: 2002-04-23; US2002-159587 Applic. Date: 2002-05-30; US20010285884P Applic. Date: 2001-04- 23

Inventor: GILLIS SCOTT H [US]; SCHECHTER PAUL [US]; BURRELL ROBERT E [CA]

Title: Solutions and aerosols of metal-containing compounds

Applicant/Assignee: BURRELL ROBERT E,

Application No.: 10/277673 Applic. Date: 2002-10-22

Abstract: Solutions and aerosols of metal-containing compounds are disclosed. Methods of preparing and using the solutions and aerosols, particularly in the treatment of a subject having a condition, are also disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.

Priority: US2000-628735 Applic. Date: 2000-07-27; US2001-916757 Applic. Date: 2001-07-27; US2001-840637 Applic. Date: 2001-04-23; US2002-128208 Applic. Date: 2002-04- 23; US2002-131509 Applic. Date: 2002-04-23; US2002-131511 Applic. Date: 2002-04-23

Inventor: BURRELL ROBERT E [CA]; GILLIS SCOTT H [US]; SCHECHTER PAUL [US]; WRIGHT JOHN B [US]; LAM KAN [US]; YIN HUA QING [CA]; NAYLOR ANTONY G [CA]; MOXHAM PETER H [CA]

Patent No.: US6908516B2 Issued: 2005-06-21

Title: Selected processing for non-equilibrium light alloys and products

Applicant/Assignee: FRANZ HEHMANN [US]

Application No.: 10/265467 Applic. Date: 2002-10-07

Abstract: A new class of light or reactive elements and monophase alpha'-matrix magnesium- and aluminum-based alloys with superior engineering properties, for the latter being based on a homogeneous solute distribution or a corrosion-resistant and metallic shiny surface withstanding aqueous and saline environments and resulting from the control during synthesis of atomic structure over microstructure to net shape of the final product, said alpha'-matrix being retained upon conversion into a cast or wrought form. The manufacture of the materials relies on the control of deposition temperature and in-vacuum consolidation during vapor deposition, on maximized heat transfer or casting pressure during all-liquid processing and on controlled friction and shock power during solid state alloying using a mechanical milling technique.

The alloy synthesis is followed by extrusion, rolling, forging, drawing and superplastic forming for which the conditions of mechanical working, thermal exposure and time to transfer corresponding metastable alpha'-matrix phases and microstructure into product form depend on thermal stability and transformation behavior at higher temperatures of said light alloy as well as on the defects inherent to a specific alloy synthesis employed. Alloying additions to the resulting alpha'-monophase matrix include 0.1 to 40 wt. % metalloids or light rare earth or early transition or simple or heavy rare earth metals or a combination thereof.

The eventually more complex light alloys are designed to retain the low density and to improve damage tolerance of corresponding base metals and may include an artificial aging upon thermomechanical processing with or without solid solution heat and quench and annealing treatment for a controlled volume fraction and size of solid state precipitates to reinforce alloy film, layer or bulk and resulting surface qualities. Novel processes are employed to spur production and productivity for the new materials.

Priority: EP19940111991 Applic. Date: 1994-08-01; WO1995EP02882 Applic. Date: 1995-07-19; US1997-776382 Applic. Date: 1997-01-31

Inventor: HEHMANN FRANZ [DE]; WEIDEMANN MICHAEL [DE]

Title: Colloidal nanosilver solution and method for making the same

Applicant/Assignee: YAN JIXIONG,

Application No.: 10/106053 Applic. Date: 2002-03-27

Abstract: The present invention provides a colloidal nanosilver solution which contains nanosilver particles having diameters between 1 nm and 100 nm. The silver content in the colloidal solution is between 0.001% to 0.4% by weight. The colloidal nanosilver solution also contains a gelling agent which includes, but is not limited to, starch or its derivative, cellulose or its derivative, polymer or copolymer of acrylate or acrylate derivative, polyvinyl pyrrolidone, alginic acid, and xanthogenated gel. The present invention also provides a method for making the colloidal nanosilver solution. The colloidal nanosilver solution prepared by this method does not contain any toxic or impure substances.

Inventor: YAN JIXIONG [CN]; CHENG JIACHONG [CN]

Title: Method for production of enhanced traceable immunizing drinking water and other liquid and gas products, devices for production and use thereof, and use of the enhanced products for immunizing living beings

Applicant/Assignee: TRIBELSKY ZAMIR,

Application No.: 10/258349 Applic. Date: 2003-05-27

Abstract: A method for the production of enhanced traceable optp-physiological polished liquids, and gases or solids or combination for immunizing living beings, devices using the method, use, and preferred mode for utilization are disclosed. A multi processing platform is proposed according to the invention harnessing time domain optronics of light & sound, wherein the transient sound produced by light is measured, referenced or calibrated against the light produced by sound for the formation adequate energy levels or densities or fluence rates for the purpose of dissociation of noxious or innocuous species or combination constituents components while keeping their geometrical integrity above their predetermined resonance levels, thus intact for later traceable recognition and triggering of positive decisive action by immune systems.

Priority: IL20000135843 Applic. Date: 2000-04-28; WO2001IL00383 Applic. Date: 2001-04-27

Inventor: TRIBELSKY ZAMIR [IL]; ENDE MICHAEL [IL]

Title: Methods of treating skin and integument conditions

Applicant/Assignee: BURRELL ROBERT E,

Application No.: 10/277362 Applic. Date: 2002-10-22

Abstract: Methods of treating skin and integument conditions, particularly with metal-containing compounds, are disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti- fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.

Priority: US2000-628735 Applic. Date: 2000-07-27; US2001-916757 Applic. Date: 2001-07-27; US2001-840637 Applic. Date: 2001-04-23; US2002-128208 Applic. Date: 2002-04-23; US2002-131511 Applic. Date: 2002-04-23; US2002-131568 Applic. Date: 2002-04-23; US2002-159587 Applic. Date: 2002-05-30; US2002-131509 Applic. Date: 2002-04-23; US20010285884P Applic. Date: 2001-04-23

Inventor: BURRELL ROBERT E [CA]; GILLIS SCOTT H [US]; SCHECHTER PAUL [US]; WRIGHT JOHN B [US]; LAM KAN [US]; YIN HUA QING [CA]

Patent No.: US7053034B2 Issued: 2006-05-30

Title: Targeted controlled delivery compositions activated by changes in pH or salt concentration

Applicant/Assignee: SHEFER ADI,

Application No.: 10/119567 Applic. Date: 2002-04-10

Abstract: The present invention relates to a novel controlled release carrier system for pH or salt triggered release and targeted delivery of fragrances and other active ingredients onto fabric, hair, skin, and other biological surfaces and which provides prolonged release of fragrances and other active ingredients over an extended period of time, or yields a high impact fragrance "burst" upon treating the target surface with heat (blow drying the hair, ironing the fabric). The controlled delivery system of the present invention is substantially a free-flowing powder formed of solid hydrophobic nano-spheres comprising the fragrance and other active ingredients that are encapsulated in a pH or salt sensitive micro-spheres. Also described are processes for preparing such compositions and processes for using same.

Furthermore, certain components of the aforementioned compositions in combination with one another are novel, and other components have novel uses in increasing fragrance substantivity, particularly in fabric, hair, and skin care preparations. The invention further pertains to consumer and diversified products comprising the controlled release system of the present invention.

Inventor: SHEFER ADI [US]; SHEFER SHMUEL DAVID [US]

Patent No.: US7115282B2 Issued: 2006-10-03

Title: Multi component controlled release system for anhydrous cosmetic compositons

Applicant/Assignee: SHEFER ADI,

Application No.: 10/124207 Applic. Date: 2002-04-17

Abstract: The present invention relates to an improved controlled release system that can be incorporated into anhydrous cosmetic formulations and can encapsulate different types of fragrances, flavors, active ingredients, or combinations of fragrances, flavors, and various active ingredients. The controlled delivery system of the present invention is substantially free-flowing powder formed of solid hydrophobic nano-spheres that are encapsulated in a moisture sensitive micro-spheres. The fragrances, flavors, and active ingredients encapsulated in the nano-spheres can be the same or different from those encapsulated in the micro-sphere.

The encapsulation of one or more fragrances, flavors or active agents in the various components of the system, such as nano-spheres and micro-spheres, provides odor or flavor transition (change in odor character or change in flavor character) during the use of the product, in response to moisture, such as wetting the lips, perspiration, and the like. The incorporation of the controlled release system of the present invention into anhydrous cosmetic formulations was found to provide moisture triggered release, as well as prolonged release of the fragrances, flavors, and active ingredients that are encapsulated in the solid hydrophobic nano-spheres over an extended period of time.

Inventor: SHEFER ADI [US]; DAVID SHEFER SHMUEL [US]

Patent No.: US7067152B2 Issued: 2006-06-27

Title: Multi component moisture triggered controlled release system that imparts long lasting cooling sensation on the target site and/or provides high impact fragrance or flavor burst

Applicant/Assignee: SHEFER ADI,

Application No.: 10/211727 Applic. Date: 2002-08-02

Abstract: The present invention relates to cosmetic formulations comprising a multi component controlled release system that imparts long lasting cooling sensation and/or provides high odor or flavor intensity (i.e., high impact fragrance or flavor burst) in response to moisture. The controlled delivery system of the present invention is substantially free-flowing powder formed of solid hydrophobic nano-spheres that are encapsulated in a moisture sensitive micro- spheres.

Priority: US2002-124207 Applic. Date: 2002-04-17

Inventor: SHEFER ADI [US]; SHEFER SAMUEL DAVID [US]

Patent No.: US7078060B2 Issued: 2006-07-18

Title: Solutions and aerosols of metal-containing compounds

Applicant/Assignee: BURRELL ROBERT E,

Application No.: 10/364983 Applic. Date: 2003-02-12

Abstract: Solutions and aerosols of metal-containing compounds are disclosed. Methods of preparing and using the solutions and aerosols, particularly in the treatment of a subject having a condition, are also disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.

Priority: US2002-277673 Applic. Date: 2002-10-22; US2001-916757 Applic. Date: 2001-07-27; US2001-840637 Applic. Date: 2001-04-23; US2000-628735 Applic. Date: 2000-07- 27; US2002-159587 Applic. Date: 2002-05-30; US2002-128208 Applic. Date: 2002-04-23; US2002-131568 Applic. Date: 2002-04-23; US2002-131511 Applic. Date: 2002-04-23; US2002-131509 Applic. Date: 2002-04- 23; US20010285884P Applic. Date: 2001-04-23

Inventor: BURRELL ROBERT E [CA]; GILLIS SCOTT H [US]; SCHECHTER PAUL [US]; WRIGHT JOHN B [US]; LAM KAN [US]; YIN HUA QING [CA]; NAYLOR ANTONY G [CA]; MOXHAM PETER H [CA]

Patent No.: US6916872B2 Issued: 2005-07-12

Title: Non-spherical nanopowder derived nanocomposites

Applicant/Assignee: YADAV TAPESH,

Application No.: 10/449282 Applic. Date: 2003-05-30

Abstract: Nanocomposites from nanofillers with preferred form of whiskers, rods, plates and fibers are disclosed. The matrix composition described includes polymers, ceramics and metals. The fillers composition disclosed include inorganic, organic and metallic. These nanocomposites are useful in wide range of applications given their unusual properties such as refractive index, transparency to light, reflection characteristics, resistivity, permittivity, permeability, coercivity, B-H product, magnetic hysteresis, breakdown voltage, skin depth, curie temperature, dissipation factor, work function, band gap, electromagnetic shielding effectiveness, radiation hardness, chemical reactivity, thermal conductivity, temperature coefficient of an electrical property, voltage coefficient of an electrical property, thermal shock resistance, biocompatibility, and wear rate.

Priority: US2001-790036 Applic. Date: 2001-02-20; US1998-083893 Applic. Date: 1998-05-22; US1996-739257 Applic. Date: 1996-10-30; US1996-730661 Applic. Date: 1996-10-11; US1996- 706819 Applic. Date: 1996-09-03; US1996-707341 Applic. Date: 1996-09-03; US19970049077P Applic. Date: 1997-06-09; US19970069936P Applic. Date: 1997-12-17; US19980079225P Applic. Date: 1998-03-24

Inventor: YADAV TAPESH [US]; KOSTELECKY CLAYTON [US]

Patent No.: US7060192B2 Issued: 2006-06-13

Title: Methods of fabricating physiological sample collection devices

Applicant/Assignee: YUZHAKOV VADIM V,

Application No.: 10/143127 Applic. Date: 2002-05-09

Abstract: Methods of fabricating devices for collecting a sample of physiological and for measuring a characteristic, e.g., an analyte concentration, of the sampled physiological sample. The devices are in the form of a test strip which include a biosensor and at least one skin-piercing element which is a planar extension of a portion of the biosensor. The fabrication methods provide various or forming the test strip and the skin-piercing element.

Inventor: YUZHAKOV VADIM V [US]; MCALLISTER DEVIN V [US]; OLSON LORIN [US]; LEONG KOON-WAH [US]; TEODORCZYK MARIA [US]; KISER ERNEST [US]

Title: Process for manufacture of hair or skin cosmetic products using apparatuses with microstructured units

Applicant/Assignee: SENDELBACH GERHARD,

Application No.: 10/426095 Applic. Date: 2003-04-29

Abstract: A process for manufacturing hair cosmetic or skin cosmetic products is described, in which the products contain a preparation with hair cosmetic or skin cosmetic ingredients and one process step includes conducting at least a part of the preparation through an apparatus with microstructured units. The apparatus with microstructured units can be one or more static micromixers and/or one or more microheat exchangers.

Priority: DE20021019523 Applic. Date: 2002-05-02

Inventor: SENDELBACH GERHARD [DE]; KELLER WALTER [DE]; SPIKA HANS JOACHIM [DE]; GOCKELN GERLINDE [DE]; SPRINGOB CHRISTIAN [DE]; ALLWOHN JUERGEN [DE]

Title: Compositions for inhibiting tumor growth and methods thereof

Applicant/Assignee: CHANG THOMAS,

Application No.: 10/391340 Applic. Date: 2003-03-18

Abstract: The present invention relates to a composition for inhibiting tumor growth, which comprises a tumor growth inhibiting enzymatic moiety in association with at least one protective carrier. The present invention further relates to the methods of inhibiting tumor growth using this composition.

Priority: US20020364584P Applic. Date: 2002-03-18

Inventor: CHANG THOMAS [CA]; YU BINGLAN [CA]

Title: Polyester polyol nanocapsules, compositions thereof, and methods of use

Applicant/Assignee: OREAL [FR]

Application No.: 10/364364 Applic. Date: 2003-02-12

Abstract: The present invention relates generally to nanocapsules having a core -envelope structure where the core contains a lipophilic active agent and the envelope contains at least one polyester polyol obtained by polycondensation of an aliphatic dicarboxylic acid with at least two alkanediols or with at least one alkanediol and at least one hydroxyalkyl alkanediol. These nanocapsules make it possible to stabilize lipophilic active agents that are difficult to stabilize, especially retinol esters such as retinyl propionate.

Priority: FR20020002290 Applic. Date: 2002-02- 22; US20020361707P Applic. Date: 2002-03-06

Inventor: SIMONNET JEAN-THIERRY [FR]; GUERIN GILLES [FR]

Title: Stabilized retinol for cosmetic dermatological, and pharmaceutical compositions, and use thereof

Applicant/Assignee: SHEFER ADI,

Application No.: 10/172292 Applic. Date: 2002-06-17

Abstract: The present invention relates to a controlled release system useful to stabilize retinol, retinol derivatives, and extracts containing retinol in cosmetic, dermatological, and pharmaceutical compositions. More specifically, the present invention pertains to stabilized retinol in a solid hydrophobic particle that sustains the release of retinol during the product shelf life and enables a gradual and prolonged release of effective levels of retinol and other cosmetic, dermatological, and pharmaceutical active ingredients into biological surfaces. The present invention also refers to a process of stabilizing retinol, retinol derivatives, and extracts containing retinol in cosmetic, dermatological, and pharmaceutical compositions. The invention further relates to cosmetic, dermatological, and pharmaceutical products comprising stable retinol in a hydrophobic particle that can deliver effective levels of retinol and other cosmetic, dermatological, and pharmaceutical active ingredients to biological surfaces over an extended period of time.

Inventor: SHEFER ADI [US]; SHEFER SAMUEL DAVID [US]

Patent No.: US7087743B2 Issued: 2006-08-08

Title: Novel oligonucleotides and use of oligonucleotides modulating the expression of enzymes involved in the synthesis of melanic pigments, as depigmentation agents

Applicant/Assignee: KURFURST ROBIN,

Application No.: 10/203398 Applic. Date: 2003-01-06

Abstract: The present invention relates to novel oligonucleotide sequences and also to derivatives thereof. These novel oligonucleotide sequences are capable of hybridizing specifically with the gene or with a product of the gene encoding tyrosinase, or with the gene or a product of the gene encoding tyrosinase-related-protein 1 (TRP-1). The present invention also relates to the use of these novel oligonucleotide sequences as a depigmenting or bleaching agent in a cosmetic composition or in a dermatological composition.

Priority: FR20000001730 Applic. Date: 2000-02-11; WO2001FR00398 Applic. Date: 2001-02-09

Inventor: KURFURST ROBIN [FR]; JOLY REGINE [FR]

Title: Use of at least one extract of a plant of the genus lannea in a cosmetic or dermopharmaceutical composition

Applicant/Assignee: PAULY GILLES,

Application No.: 10/404337 Applic. Date: 2003-04-01

Abstract: A cosmetic composition containing: (a) at least one plant extract from a plant belonging to a genus selected from the group consisting of Lannea, Odina, and mixtures thereof

and (b) at least one active ingredient selected from the group consisting of an anti-radical agent, a tyrosinase-inhibiting agent, a melanogenesis- inhibiting agent, an anticollagenase agent, an antielastase agent, a cytoprotective agent, and mixtures thereof, for application onto a human substrate selected from the group consisting of skin, mucous membranes and epithelial appendages.

Priority: FR19990009428 Applic. Date: 1999-07-19; US2002-031720 Applic. Date: 2002-04-17

Inventor: PAULY GILLES [FR]; MOSER PHILIPPE [FR]; DANOUX LOUIS [FR]

Patent No.: US7531120B2 Issued: 2009-05-12

Title: Method of making a product with a micro or nano sized structure and product

Applicant/Assignee: VAN RIJN CORNELIS JOHANNES MARIA,

Application No.: 10/433275 Applic. Date: 2003-09-29

Abstract: Using phase separation technique perforated as well as non-perforated polymeric structures can be made with high aspect ratios (>5). By varying the phase separation process the properties (e.g. porous, non-porous, dense, open skin) of the moulded product can be tuned. Applications are described in the field of micro fluidics (e.g. micro arrays, electrophoretic boards), optics, polymeric solar cells, ball grid arrays, and tissue engineering.

Priority: NL20001016779 Applic. Date: 2000-12-02; WO2001NL00874 Applic. Date: 2001-12-03

Inventor: VAN RIJN CORNELIS JOHANNES MAR [NL]; VOGELAAR LAURA [NL]; NIJDAM WIETZE [NL]; BARSEMA JONATHAN NATHANIEL [NL]; WESSLING MATTHIAS [NL]

Title: Pharmaceutical composition for treatment and /or prevention of a light- dermatosis

Applicant/Assignee: HANS DIETER PRENTNER [AT]

Application No.: 10/431624 Applic. Date: 2003-05-07

Abstract: A pharmaceutical composition for treatment and prevention of light dermatosis includes (i) a medical drug form nopal cactus, and (ii) at least one active substance with light-dermatosis therapeutic properties and wherein the pharmaceutical composition is provided in a suitable form for topical application.

Priority: DE20022014753U Applic. Date: 2002-09-24

Inventor: WOLF PETER [AT]; DOLINSCHEK KARL-HEINZ [AT]

Title: Container closure with a multi-layer oxygen barrier liner

Applicant/Assignee: GOLDMAN ANATOLIY

Application No.: 10/282583 Applic. Date: 2002-10-29

Abstract: A container closure with a multiple layer liner. The liner comprises a nylon gas transmission barrier and a non-nylon layer bonded by an adhesive layer. The nylon gas transmission barrier may contain an additional passive gas transmission component comprising an in-situ polymerized inorganic clay. An additional active gas transmission component comprising a chemically reactive scavenger may be incorporated into at least one layer of the multiple layer liner. Materials of the liner are selected for their process conditions and resulting resistance to degradation.

Inventor: GOLDMAN ANATOLIY [US]

Title: Prophylactic treatment methods

Applicant/Assignee: GILLIS SCOTT H,

Application No.: 10/690710 Applic. Date: 2003-10-22

Abstract: Prophylactic treatment methods are disclosed. The methods can include contacting an object and/or an area of a subject with a metal-containing material to reduce the occurrence of a condition at the same area or a different area of the subject. The metal-containing material can be, for example, an antimicrobial material, an anti-biofilm metal-containing material, an antibacterial material, an anti- inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro- apoptosis material, an anti-proliferative material, an MMP modulating material, an atomically disordered, crystalline material, and/or a nanocrystalline material. In certain embodiments, the metal- containing material is an atomically disordered, nanocrystalline silver-containing material.

Priority: US20020420167P Applic. Date: 2002-10-22

Inventor: GILLIS SCOTT H [US]; SCHECHTER PAUL [US]; DEMLING ROBERT H [US]

Title: Methods, compositions and apparatuses for detecting a target in a preservative solution

Applicant/Assignee: CYTYC CORP [US]

Application No.: 10/618443 Applic. Date: 2003-07-11

Abstract: This invention relates to methods, articles and compositions useful in detecting target substances in an alcoholic preservative solution, and for identifying sensors useful for binding to such targets. The methods allow for the simultaneous performance of sufficient fixation of a sample and binding of a detectable sensor to a target of interest in the sample. In one aspect, a method is provided that comprises contacting a sample suspected of containing a target with a detectable sensor molecule known to bind to such target in an alcoholic preservative solution. The method may be performed in multiplex form to permit simultaneous analysis of a plurality of targets. Methods for identifying a sensor capable of binding to a desired target in an alcoholic preservative solution are also provided. An alcoholic preservative solution comprising one or more such detectable sensors is also provided. Also provided is a sample comprising a bound sensor provided by such a process. Also provided are kits useful for such methods.

Priority: US20000225524P Applic. Date: 2000-08-15; US20000194304P Applic. Date: 2000-04-03; US2001-825482 Applic. Date: 2001-04-03

Inventor: LINDER JAMES [US]; COHENFORD MICHAEL [US]; COFFMAN ERIN [US]; LENTRICHIA BRIAN B [US]

Title: Method for producing proteins by fermentation of microorganisms from the thermus family the protein mixture thus obtained and cosmetic compositions containing same

Applicant/Assignee: LINTNER KARL

Application No.: 10/468081 Applic. Date: 2004-01-08

Abstract: The use of fermentation media for microorganisms from the Thermus family, in particular microorganisms collected in marine waters close to very deep hydrothermal sources, especially those obtained with the GY1211 strain. Cosmetic compositions containing one or more types of fermentation media for the microorganisms and which are used, in particular, for skin care, notably for the face, body and scalp, and hair care and in order to modulate the cutaneous concentration of ceramides, to stimulate the immune system, to provide protection by means of the chaperone effect and a detoxifying and anti-free radical effect, particularly in relation to the oxygen peroxide.

Priority: FR20010002442 Applic. Date: 2001-02-21; WO2002FR00488 Applic. Date: 2002-02-07

Inventor: LINTNER KARL [FR]

Title: Cosmetic or dermopharmaceutical compositions of ceramides and polypeptides

Applicant/Assignee: SEDERMA S A S [FR]

Application No.: 10/742344 Applic. Date: 2003-12-19

Abstract: Personal care products including cosmetics, grooming products and topical pharmaceutical products can be produced including a polypeptide of between 3 and 12 amino acids in length and a ceramide. These formulations are particularly useful in addressing wrinkles in human subjects and in particular facial skin and hands. Certain analogs and derivatives of these polypeptides may be used in these formulations and/or alone. Methods of using these formulations are also disclosed.

Priority: FR20030005707 Applic. Date: 2003-05-12

Inventor: LINTNER KARL [FR]; GABRIELE DENISE E [US]

Title: Particles comprising a biopolymer which is degradable under the effect of an electromagnetic wave as emitted by a solar radiation

Applicant/Assignee: COLETICA [FR]

Application No.: 10/346690 Applic. Date: 2003-01-15

Abstract: The invention relates mainly to a particle comprising at least one biopolymer which is degradable under the effect of an electromagnetic wavelength, notably the wavelength of which is in the spectrum of the wavelengths emitted by the sun, this biopolymer comprising nucleosides. The invention also relates to compositions containing such particles with the aim of delivering an active principle. These particles can be used mainly in cosmetics, in dermatology, in pharmacy, in agri-food or en agro-industrials.

Priority: FR20020016637 Applic. Date: 2002- 12-24

Inventor: PERRIER ERIC [FR]; BONNET ISABELLE [FR]; DE MATTEIS CHARLOTTE [FR]

Patent No.: US7427416B2 Issued: 2008-09-23

Title: Methods of treating conditions using metal-containing materials

Applicant/Assignee: GILLIS SCOTT H,

Application No.: 10/690724 Applic. Date: 2003-10-22

Abstract: Methods of treating conditions using metal-containing materials are disclosed. Exemplary conditions include bacterial conditions, biofilm conditions, microbial conditions, inflammatory conditions, fungal conditions, viral conditions, autoimmune conditions, idiopathic conditions, hyperproliferative conditions, noncancerous growths, cancerous conditions and combinations of such conditions. In certain embodiments, the metal-containing material is an atomically disordered, nanocrystalline silver-containing material.

Priority: US2001- 916757 Applic. Date: 2001-07-27; US2000-628735 Applic. Date: 2000-07-27; US2002-159587 Applic. Date: 2002-05-30; US2002-131568 Applic. Date: 2002-04-23; US2001-840637 Applic. Date: 2001-04-23; US2002- 131511 Applic. Date: 2002-04-23; US2002-131509 Applic. Date: 2002-04-23; US2002-128208 Applic. Date: 2002-04-23; US2002-277673 Applic. Date: 2002-10-22; US2002-277356 Applic. Date: 2002-10-22; US2002- 277298 Applic. Date: 2002-10-22; US2002-277362 Applic. Date: 2002-10-22; US2002-277358 Applic. Date: 2002-10-22; US2002-277320 Applic. Date: 2002-10-22; US20010285884P Applic. Date: 2001-04-23

Inventor: GILLIS SCOTT H [US]; SCHECHTER PAUL [US]; STILES JAMES ALEXANDER ROBERT [CA]

Patent No.: US7462388B2 Issued: 2008-12-09

Title: Conductive resin molded product having insulating skin and method for forming the same

Applicant/Assignee: KOIDE ATSUSHI,

Application No.: 10/722116 Applic. Date: 2003-11-25

Abstract: To make the surface of a conductive resin molded product nonconductive with the resin by adopting a carbon nano material as a conductive compounding material, and, accordingly, to make it possible to expand the use of the conductive resin molded product and use it as a base material of electronic equipment. The conductive resin molded product is produced out of composite material of nonconductive resin and the carbon nano material. The conductive resin molded product is comprised of an insulating skin 1 of the resin formed by blend control of the carbon nano material and the conductive core 2 coated with the insulating skin 1.

Priority: JP20020347673 Applic. Date: 2002-11-29

Inventor: KOIDE ATSUSHI [JP]; YAMAGIWA YOSHITOSHI [JP]; SUGANUMA MASASHI [JP]; TAKAHASHI YOSHIHIKO [JP]

Title: Nonaerosol/aerosol dispensing of sunscreen sprays comprising silica microparticles

Applicant/Assignee: OREAL [FR]

Application No.: 10/717523 Applic. Date: 2003-11-21

Abstract: Nonaerosol/atomizer pumps or aerosol dispensers comprise (A) a reservoir confining at least one vaporizable sunscreen composition suited for UV-photoprotecting the skin and/or hair against the damaging effects of UV radiation, the at least one vaporizable sunscreen composition comprising (1) a UV-photoprotecting amount of at least one UV-sunscreen and (2) an SPF- enhancing amount of generally spherical silica microparticles, formulated into (3) a topically applicable, cosmetically acceptable carrier therefor, and (B) at least one agent for pressurizing the at least one vaporizable sunscreen composition into a spray of fine sunscreen particles.

Priority: FR20020014599 Applic. Date: 2002-11-21; US20030449574P Applic. Date: 2003-02-26

Inventor: JOSSO MARTIN [FR]

Title: Liquid foam producing compositions and dispensing system therefor

Applicant/Assignee: PAUL LEONARD

Application No.: 10/777986 Applic. Date: 2004-02-11

Abstract: By providing a therapeutic agent in a mixture of surfactants and water, a unique, improved, liquid based foam producing formulation is realized which is useable for a wide variety of applications. In the preferred embodiment, the improved liquid based foaming producing formulations incorporate one or more therapeutic agents which comprise a silver-based composition. As a result, the formulation is useable for a wide variety of medical applications for preventing, treating, or reducing the spread or transmission of bacteria, virus, infections, and the like.

Priority: US2002-090064 Applic. Date: 2002-03-01; US2001-783060 Applic. Date: 2001-02-14; US20000183307P Applic. Date: 2000-02-17

Inventor: PAUL LEONARD [US]

Patent No.: US7132122B2 Issued: 2006-11-07

Title: Direct micro-patterning of lipid bilayers using UV light and selected uses thereof

Applicant/Assignee: UNIV CALIFORNIA [US]

Application No.: 10/698995 Applic. Date: 2003-10-30

Abstract: This invention provides novel methods for creation of patterned lipid bilayer membranes as well as methods for refunctionalization of such patterned membranes with selected components. Such components optionally comprise, e.g., lipid bilayer membranes (which optionally comprise specific proteins), proteins, non-biologic moieties, etc.

Priority: US20020422902P Applic. Date: 2002-10-30; US20020423327P Applic. Date: 2002-10-31; US20030469928P Applic. Date: 2003-05-12; US20030496256P Applic. Date: 2003-08-18

Inventor: PARIKH ATUL NAVINCHANDRA [US]; YEE CHANEL KITMON [US]; AMWEG MERI LYNN [US]

Title: Compositions and methods of metal-containing materials

Applicant/Assignee: BURRELL ROBERT E,

Application No.: 10/690715 Applic. Date: 2003-10-22

Abstract: Compositions and methods of metal-containing materials of metal-containing materials are disclosed. The metal-containing material can be, for example, an antimicrobial material, an anti-biofilm material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, anti-proliferative, MMP modulating material, an atomically disordered, crystalline material, and/or a nanocrystalline material. In certain embodiments, the metal-containing material is an atomically disordered, nanocrystalline silver-containing material.

Priority: US2000-628735 Applic. Date: 2000-07-27; US2001-916757 Applic. Date: 2001-07-27; US2001-840637 Applic. Date: 2001-04- 23; US2002-128208 Applic. Date: 2002-04-23; US2002-131509 Applic. Date: 2002-04-23; US2002-131511 Applic. Date: 2002-04-23; US2002-131568 Applic. Date: 2002-04-23; US2002-159587 Applic. Date: 2002-05- 30; US2002-277673 Applic. Date: 2002-10-22; US2002-277356 Applic. Date: 2002-10-22; US2002-277298 Applic. Date: 2002-10-22; US2002-277362 Applic. Date: 2002-10-22; US2002-277358 Applic. Date: 2002-10- 22; US2002-277320 Applic. Date: 2002-10-22; US20010285884P Applic. Date: 2001-04-23

Inventor: BURRELL ROBERT E [CA]; WRIGHT JOHN B [US]; LAM KAN [US]; YIN HUA QING [CA]; NAYLOR ANTONY G [CA]; MOXHAM PETER H [CA]; GILLIS SCOTT H [US]; SCHECHTER PAUL [US]; ROBERT STILES JAMES ALEXANDER [CA]

Title: Cosmetic composition with skin tightening effect

Applicant/Assignee: DELAGE-GROUILLER HERVE,

Application No.: 10/487693 Applic. Date: 2004-02-26

Abstract: The present invention relates to a mixture, having a skin-tightening effect, which is made up of: 10 to 80% by weight of a polysaccharide, preferably of an alginate, having a molecular weight of less than 600,000 Daltons, preferably less than 400,000 Daltons and more preferably less than 200,000 Daltons, 15 to 75% by weight of a polyhydroxylated agent selected from sugars and their derivatives, particularly sugar esters and sugar ethers, preferably sorbitol, 3 to 15% by weight of poly(vinyl alcohol) or polyvinylpyrrolidone, and 0 to 25% by weight of cellulose or of a derivative of cellulose, such as carboxymethylcellulose or hydroxymethylcellulose. The present invention also relates to cosmetic compositions which contain this mixture. These cosmetic compositions enable a mechanical smoothing of the surface of the skin to be obtained progressively with great comfort of use and enables a good fixing of make-up products.

Priority: FR20010011123 Applic. Date: 2001-08-27; WO2002FR02941 Applic. Date: 2002-08-27

Inventor: DELAGE-GROUILLER HERVE [FR]; NOE BRIGITTE [FR]; MAHE CHRISTIAN [FR]

Title: Skin abrasive agents

Applicant/Assignee: MCDANIEL DAVID H

Application No.: 10/665390 Applic. Date: 2003-09-22

Abstract: The present invention relates to compositions and methods for microderm abrasion. In particular, the invention employs micro-sized particles that may be impacted into mammalian skin. The particles may, themselves, include an active agent that is to be delivered through the stratum corneum, or an active agent may be delivered through the abraded stratum corneum. The stratum corneum may be abraded by active agents or topical compositions formed into particles, hyperbaric particles, or other means.

Priority: US20020411870P Applic. Date: 2002-09-20

Inventor: MCDANIEL DAVID H [US]

Title: Methods and ink compositions for invisibly printed security images having multiple authentication features

Applicant/Assignee: ANGSTROM TECHNOLOGIES INC [US]

Application No.: 10/818058 Applic. Date: 2004-04-05

Abstract: An article is marked with image indicia for authentication, information, or decoration by providing a plurality of inks having a plurality of fluorescence colors when exposed to excitation energy, separating colors of the image indicia into a plurality of image levels in accordance with the fluorescence colors of the inks, and printing each image level in mutual registration on the article using the corresponding ink. The image printed with each ink may be substantially invisible under illumination within the visible spectrum. The invisibly printed images have multiple authentication features, including the use of covert UV-fluorescent materials, IR-fluorophores, microparticles, and other chemical taggants. Ink compositions, methods for making the inks, and methods and apparatus for using the inks are also disclosed.

Priority: US20030460599P Applic. Date: 2003-04-04

Inventor: COYLE WILLIAM J [US]; SMITH JOHN C [US]

Patent No.: US7046439B2 Issued: 2006-05-16

Title: Optical element with nanoparticles

Applicant/Assignee: EASTMAN KODAK CO [US]

Application No.: 10/443387 Applic. Date: 2003-05-22

Abstract: Disclosed is an optical element comprising a substrate with surface features on a surface thereof having an Ra of from 3 to 200 micrometers containing a dispersion of minute particles having a particle size dimension less than 100 nanometers.

Inventor: KAMINSKY CHERYL J [US]; BOURDELAIS ROBERT P [US]; IRVIN GLEN C [US]

Patent No.: US7182963B2 Issued: 2007- 02-27

Title: Cosmetic and dermopharmaceutical compositions for skin prone to acne

Applicant/Assignee: SEDERMA [FR]

Application No.: 10/817670 Applic. Date: 2004-04-02

Abstract: The invention relates to the use of an extract of olive leaves (Olea europaea) which is titrated in oleanolic acid and which may or may not be associated with a Larrea divaricata extract which is titrated in nordihydroguaiaretic acid (NDGA). Said products are intended for all types of cosmetic and dermopharmaceutical compositions for all forms of skin care, for moisturizing and anti-inflammatory purposes and, in particular, for the prevention and treatment of skin prone to acne.

Priority: FR20010012802 Applic. Date: 2001-10-03; WO2002FR03344 Applic. Date: 2002-10-01

Inventor: LINTNER KARL [FR]

Patent No.: US7108485B2 Issued: 2006-09-19

Title: Reduction in the noise produced by a rotor blade of a wind turbine

Applicant/Assignee: WOBBEN ALOYS

Application No.: 10/802568 Applic. Date: 2004-03-17

Abstract: Rotor blades for wind power installations are known in many different forms. In a wind power installation the rotors or the rotor blades thereof represent the main source of sound. For reasons relating to acceptance and noise prevention laws, the aim should/must be that of minimizing the levels of sound emission as wind power installations are often also set up in the proximity of residential accommodation.

The levels of sound emission which hitherto occur with a wind power installation or a wind power converter also mean that wind power installations are faced with resistance from populated areas because of the sound they produce and for that reason such installations can be accepted sometimes with difficulty or not at all as authorities responsible for planning permission refuse permission for wind power installations because of the existing environmental requirements, noise also being an environmentally polluting factor. Therefore the object of the invention is further to improve the noise emission of wind power installations. Wind power installation rotor blade comprising means for reducing the sound produced by a rotor blade, wherein the means is formed by a fluid-repellent layer and/or surface which is provided at least on a surface portion of the rotor blade.

Priority: DE19982022003U Applic. Date: 1998-12-09; DE19991029386 Applic. Date: 1999-06-28; DE19991047211 Applic. Date: 1999-10-01; DE19991051346 Applic. Date: 1999-10-25; US2001-857925 Applic. Date: 2001-08-27; WO1999EP09691 Applic. Date: 1999-12-09

Inventor: WOBBEN ALOYS [DE]

Patent No.: US7232605B2 Issued: 2007-06-19

Title: Hybrid natural-fiber composites with cellular skeletal structures

Applicant/Assignee: UNIV MICHIGAN STATE [US]

Application No.: 10/892859 Applic. Date: 2004-07-16

Abstract: The present invention relates to composite structural members comprising polymers, natural and synthetic fibers, and nano-scale platelets arranged in two- or three-dimensional cellular skeletal structure

more particularly referring to a low- cost natural-fiber based structural member with material hybridization and material layout for improved behavior that leads to efficient structural beam and plate/panel components that can be used in a plurality of modular structures, resulting in lower cost and reduced environmental impact.

Priority: US20030487971P Applic. Date: 2003-07-17

Inventor: BURGUENO RIGOBERTO [US]; MOHANTY AMAR K [US]; QUAGLIATA MARIO JOHN [US]

Patent No.: US7181266B2 Issued: 2007-02-20

Title: Materials and methods for near-infrared and infrared lymph node mapping

Applicant/Assignee: FRANGIONI JOHN V,

Application No.: 10/772425 Applic. Date: 2004-02-06

Abstract: A lymphatic system can be imaged with emissive semiconductor nanocrystals, for example, in the near infrared.

Priority: US20030451246P Applic. Date: 2003-03-04

Inventor: FRANGIONI JOHN V [US]; BAWENDI MOUNGI G [US]; KIM SUNGJEE [US]; LIM YONG TAIK [KR]

Title: Multilayer containers and process for forming multilayer containers

Applicant/Assignee: AHERN BRIAN F,

Application No.: 10/480540 Applic. Date: 2004-07-02

Abstract: A co-injection process is provided for fabricating improved multi-layer containers, including but not limited to blood collection tubes, evacuated blood collection tubes, culture bottles, centrifuges tubes, and syringe barrels. The container includes a tube (10) having a bottom wall (12) and a side wall (14) with an open end (18). The container can be provided with a stopper having an upper portion (22) and a skirt with an outside portion (30), a well (34) and a cavity (36). The tube and stopper assembly can be used for medical purposes including containing a blood sample within an enclosed interior space (40).

Priority: US20010298957P Applic. Date: 2001-06-18; WO2002US18972 Applic. Date: 2002-06-14

Inventor: AHERN BRIAN F [US]; GRIPPI NICHOLAS A [US]; SOSKEY PAUL R [US]; CARANO DONALD J [US]; HUTTON NORMAN J [US]; DESALVO DANIELLE M [US]; LUSARDI GREGORY L [US]

Title: Method and composition for the treatment of cancer by the enzymatic conversion of soluble radioactive toxic precipitates in the cancer

Applicant/Assignee: MAYERS GEORGE L,

Application No.: 10/898585 Applic. Date: 2004-07-23

Abstract: The invention features compositions and methods for treating or alleviating a symptom of cancer. The compositions and methods of the invention direct supra-lethal doses of radiation, called Hot-Spots, to virtually all cancer cell types.

Priority: US2002-226288 Applic. Date: 2002-08-22; US1999- 314422 Applic. Date: 1999-05-18; US1997-782219 Applic. Date: 1997-01-13

Inventor: MAYERS GEORGE L [US]; ROSE SAMUEL [US]; ROSE LOTTIE [US]

Patent No.: US7671009B2 Issued: 2010-03-02

Title: Dermopharmaceutically and cosmetically active oligopeptides

Applicant/Assignee: LUDIN CHRISTIAN,

Application No.: 10/493856 Applic. Date: 2004-10-18

Abstract: Oligopeptides and derivatives thereof, peptide analogs and derivatives thereof as well as pharmaceutically acceptable salts of these compounds, which correspond to general formula (I) wherein R<1 >represents H, -C(O)-R<7>, -SO2-R<7>, -C(O)-OR<7 >or -C(O)-N(R<7>)2 R<2 >represents, independent of one another, H or -(C1-C4)-alkyl, R<3 >and R<6 >represent, independent of one another, -(CH2)q-N(R<1>) R<8 > R<4 >and R<5 >represent, independent of one another, -CH2-OR<2>, -CH(CH3)OR<8 >or -CH2-CH2-OR<8 > R<7 >represents hydrogen, optionally substituted (C1-C19)-alkyl

optionally substituted (C1-C19)- alkenyl

phenyl-(C1-C4)-alkyl whose phenyl radical is optionally substituted with amino in the para position R<8 >represents H, -(C1-C4)-alkyl, -C(O)-R<7>, -C(O)-OR<7>, -C(O)-N(R<7>)2 or -SO2-R<7 > X represents oxygen (-O-) or -NH-

or XR<7>, with X=O, also represents the esters of alpha- tocopherol, tocotrienol or retinol or the carboxylic acid (with R<7>=H) m, n, p represent, independent of one another, zero or 1 and q in R<3 >and R<6 >represent, independent of one another, an integer from 1 to 4, with the provision that the following conditions do not simultaneously occur: R<4>=-CH(CH3)-OH and R<5>=-CH(CH3)-OH and R<6>=-(CH2)4-NH2

dermopharmaceutically and/or cosmetically active compositions containing at least one compou

Priority: CH20010001986 Applic. Date: 2001-10- 30; WO2002CH00587 Applic. Date: 2002-10-30

Inventor: LUDIN CHRISTIAN [CH]; HEIDL MARC [DE]; ZIEGLER HUGO [CH]

Title: Analyte sample detection

Applicant/Assignee: CYTYC CORP [US]

Application No.: 10/672914 Applic. Date: 2003-09-25

Abstract: A method for assaying a sample for the presence of a target is provided. The method comprises drawing a liquid sample transversely through a filter using an automated device that can control the rate of flow through the filter. A sensor molecule is attached to the filter which can bind to a target molecule. Binding of the target to the attached sensor molecule can then be detected through any of various techniques. The methods may be performed in multiplex form to permit simultaneous analysis of a plurality of targets. Kits for performing the methods are also provided.

Inventor: LENTRICHIA BRIAN B [US]

Title: Zinc oxide containing surfactant solution

Applicant/Assignee: COLGATE PALMOLIVE CO [US]

Application No.: 10/777734 Applic. Date: 2004-02-12

Abstract: A cleaning composition for all purpose cleaners, light duty liquids, shampoos, foam baths, liquid hand soaps, fine fabric detergents, liquid skin cleansing products, dishware paste, dishware bars and shower gels which include at least one surfactant, zinc oxide having a particle size of 10 to 30 nm, and water.

Priority: US2003-681935 Applic. Date: 2003-10-09

Inventor: PAYE MARC [BE]

Patent No.: US7344530B2 Issued: 2008-03-18

Title: Thermal surgical procedures and compositions

Applicant/Assignee: BISCHOF JOHN C,

Application No.: 10/810956 Applic. Date: 2004-03-26

Abstract: Methods, compositions, and systems useful to enhance a thermal surgical procedure are described. Compositions include at least one compound effective to induce an inflammatory response in biological material identified to undergo a thermal surgical procedure. Methods and systems include providing compositions of the invention to biological materials and treating biological materials with an inflammation inducing composition for a time, amount, and type effective to induce inflammation in at least a portion of the biological material.

Priority: US20030457691P Applic. Date: 2003-03-26

Inventor: BISCHOF JOHN C [US]; BELCHER JOHN D [US]; VERCELLOTTI GREGORY M [US]

Title: Detection and quantification of prion isoforms in neurodegenerative diseases using mass spectrometry

Applicant/Assignee: EVERETT NICHOLAS P,

Application No.: 10/475234 Applic. Date: 2004-10-18

Abstract: Disclosed are methods, compositions and kits for diagnosing prion-mediated pathological conditions and presence of aberrant prion protein in animal derived products, utilizing mass spectrometry.

Priority: US20010284237P Applic. Date: 2001-04-17; US20010284705P Applic. Date: 2001-04-18; WO2002US12012 Applic. Date: 2002-04-17

Inventor: EVERETT NICHOLAS P [US]; PETELL JAMES K [US]

Title: Nanoporous diaphragm for electromagentic transducer

Applicant/Assignee: TURNMIRE PATRICK M,

Application No.: 10/693108 Applic. Date: 2003-10-24

Abstract: An electromagnetic transducer such as a tweeter audio speaker, having a very low density diaphragm constructed of a nanoporous material such as aerogel or the like. The solid aerogel diaphragm has improved rigidity and reduced susceptibility to breakup modes. The aerogel may be provided with a skin of e.g. metal, plastic, or oxide to protect it, and it may be built by filling a conventional cone. The skin may encapsulate part or all of the aerogel body's surface, and it may further encapsulate the bobbin, or even the entire voice coil assembly. The nanoporous material comprises a very large percentage of the diaphragm's overall volume, giving the diaphragm a very low overall mass density with respect to conventional diaphragms. This allows diaphragm configurations, such as solid filled spheres, which have excellent stiffness without suffering from the large mass that such shapes would mandate if constructed from conventional materials.

Inventor: TURNMIRE PATRICK M [US]; STILES ENRIQUE M [US]; CALDERWOOD RICHARD C [US]

Title: Method, apparatus and system for nanovibration coating and biofilm prevention associated with medical devices

Applicant/Assignee: ZUMERIS JONA,

Application No.: 10/986530 Applic. Date: 2004-11-10

Abstract: An acoustic indwelling medical device system, which may include a vibration apparatus and at least one transducer, may be integrated with standard medical devices. This acoustic system may use electric signals to enable the transducer to generate nanovibrations within the indwelling medical device system, to inhibit the entry of microorganisms from external sources. Such vibrations may enable dispersal of microbe colonies, thereby preventing or dispersing biofilm that may cause infections.

Priority: WO2003IL00452 Applic. Date: 2003-05-29; US20040556266P Applic. Date: 2004-03-24

Inventor: ZUMERIS JONA [IL]; HAZAN ZADICK [IL]; ZUMERIS YANINA [IL]

Patent No.: US7291497B2 Issued: 2007-11-06

Title: Medical device for analyte monitoring and drug delivery

Applicant/Assignee: HOLMES ELIZABETH A,

Application No.: 10/937872 Applic. Date: 2004-09-10

Abstract: The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte

a reservoir which comprises at least one therapeutic agent and is capable of releasing the therapeutic agent(s) from the medical device

and a plurality of microchips comprising a microarray scanning device capable of obtaining physical parameter data of an interaction between the disease marker biological analyte with the bioactive agent

a biometric recognition device capable of comparing the physical parameter data with an analyte interaction profile

optionally a therapeutic agent releasing device capable of controlling release of the therapeutic agent from the reservoirs

an interface device capable of facilitating communications between the microarray scanning device, biometric recognition device and the therapeutic agent releasing device

and an energy source to power the medical device. Specifically, the invention relates to a medical device capable of detecting an analyte in a bodily fluid comprising at least one microneedle capable of obtaining a sample of a bodily fluid, a first microchannel through which the sample flows and is in fluid communication with the at least one microneedle, a second microchannel in fluid communication with the first microchannel, through which a buffer flows, wherein the second channel comprises a microarray with a bioactive agent, a microarray scanning device to detect an interaction between the bioactive agent and the analyte in the bodily fluid

and an interface device.

Priority: US20030501847P Applic. Date: 2003- 09-11

Inventor: HOLMES ELIZABETH A [US]

Patent No.: US7235295B2 Issued: 2007-06-26

Title: Polymeric nanofibers for tissue engineering and drug delivery

Applicant/Assignee: LAURENCIN CATO T,

Application No.: 10/938493 Applic. Date: 2004-09-10

Abstract: Polymeric nanofibers have been developed which are useful in a variety of medical and other applications, such as filtration devices, medical prosthesis, scaffolds for tissue engineering, wound dressings, controlled drug delivery systems, cosmetic skin masks, and protective clothing. These can be formed of any of a variety of different polymers, either non-degradable or degradable. In a preferred embodiment demonstrated in the following examples, nanofibers are formed of biodegradable and non biodegradable polyphosphazenes, their blends with other polyphosphazenes or with organic, inorganic/organometallic polymers as well as composite nanofibers of polyphosphazenes with nanosized particles such as hydroxyapatites.

Priority: US20030501897P Applic. Date: 2003-09-10

Inventor: LAURENCIN CATO T [US]; NAIR LAKSHMI SREEDHARAN [US]; BHATTACHARYYA SUBHABRATA [US]; ALLCOCK HARRY R [US]; BENDER JARED D [US]; BROWN PAUL W [US]; GREISH YASER E [US]

Patent No.: US6942714B2 Issued: 2005-09-13

Title: NANO DIATOMITE AND ZEOLITE CERAMIC CRYSTAL POWDER

Applicant/Assignee: YU EUKKI Q,

Application No.: 10/351518 Applic. Date: 2003-01-27

Abstract: A nano diatomite and zeolite ceramic crystal powder which is a new environmental material made by combining high-quality natural diatomite and zeolite together and by using most advanced nano technology, wherein the ceramic crystal powder has the capability of producing great benefits for society through advances in health care, a cleaner environment, and agriculture.

Inventor: YU EUKKI Q [US]

Title: Medicament to treat a fibrotic disease

Applicant/Assignee: KREUTZER ROLAND,

Application No.: 10/493686 Applic. Date: 2004-05-24

Abstract: The invention concerns a medicament to treat a fibrotic disease, wherein the medicament contains a double-stranded ribonucleic acid (dsRNA) that is suitable for inhibiting by RNA interference the expression of a gene that is involved in the formation of extracellular matrix.

Priority: DE20011055280 Applic. Date: 2001-10-26; WO2002EP11972 Applic. Date: 2002-10-25; DE20011058411 Applic. Date: 2001-11-29; DE20011060151 Applic. Date: 2001-12- 07; DE20021035621 Applic. Date: 2002-08-02; WO2002EP00151 Applic. Date: 2002-01-09; WO2002EP00152 Applic. Date: 2002-01-09

Inventor: KREUTZER ROLAND [DE]; LIMMER STEFAN [DE]; SCHUPPAN DETLEF [DE]; JOHN MATTHIAS [DE]; BAUER MICHAEL [DE]

Title: Methods and compositions for tissue repair

Applicant/Assignee: BETZ OLIVER B,

Application No.: 10/917265 Applic. Date: 2004-08-11

Abstract: Methods and compositions for tissue repair are provided. The methods involve obtaining tissue from a patient, including for example, muscle or fat tissue, and contacting the tissue with one or more bioactive agents to induce at least a portion of the cells in the tissue to differentiate into cells of a desired type. The methods and compositions may be used to treat lesions in a variety of tissues, including bone fractures or other injuries.

Priority: US20030494484P Applic. Date: 2003-08-12

Inventor: BETZ OLIVER B [US]; BETZ VOLKER M [US]; EVANS CHRISTOPHER H [US]

Title: Dry powders of metal- containing compounds

Applicant/Assignee: NUCRYST PHARMACEUTICALS CORP A

Application No.: 10/998499 Applic. Date: 2004-11-29

Abstract: Dry powders of metal-containing compounds are disclosed. Methods of preparing and using the dry powders, particularly in the treatment of a subject having a condition, are also disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.

Priority: US2002-277298 Applic. Date: 2002-10-22; US2001-916757 Applic. Date: 2001-07-27; US2000-628735 Applic. Date: 2000-07-27; US2002- 159587 Applic. Date: 2002-05-30; US2002-131568 Applic. Date: 2002-04-23; US2001-840637 Applic. Date: 2001-04-23; US2002-131511 Applic. Date: 2002-04-23; US2002-131509 Applic. Date: 2002-04-23; US2002- 128208 Applic. Date: 2002-04-23; US20010285884P Applic. Date: 2001-04-23

Inventor: GILLIS SCOTT H [US]; SCHECHTER PAUL [US]; BURRELL ROBERT E [CA]

Title: Cosmetic or dermopharmaceutical compositions which are used to reduce bags and circles under the eyes

Applicant/Assignee: LINTNER KARL

Application No.: 10/504643 Applic. Date: 2005-02-25

Abstract: The invention relates to novel cosmetic or dermopharmaceutical compositions for topical use which are used to prevent the symptoms of cutaneous slackening and, more specifically, to treat the visible signs of ageing and fatigue, such as bags and circles under the eyes. The inventive compositions comprise, in a cosmetically-acceptable medium, a combination of at least two, and preferably three, components selected from: a) hesperidin or the derivatives thereof

b) A.C.E. enzyme inhibitor dipeptides

and c) oligopeptides R2-(AA)n- Pro-Arg-OH, wherin (AA)n is a peptide chain, (AA) is any amino acid or any derivative of any amino acid, n is included between 1 and 3, and R2-H or an alkyl chain having a carbon length of between C2 and C22.

Priority: FR20020001967 Applic. Date: 2002-02-15; WO2003FR00441 Applic. Date: 2003-02-10

Inventor: LINTNER KARL [FR]

Patent No.: US7338928B2 Issued: 2008-03-04

Title: System and process for releasing encapsulated active ingredients

Applicant/Assignee: LAU WILLIE,

Application No.: 11/003869 Applic. Date: 2004-12-03

Abstract: The present invention relates to a controlled release system that can be incorporated in cosmetic, personal care, and household products to effectively encapsulate wide range of active ingredients and sensory markers and release them in response to moisture or over an extended period of time. The controlled release system of the present invention consists of oil absorbing polymer nanospheres coated with water sensitive surface active polymers.

Priority: US20030528922P Applic. Date: 2003-12-11

Inventor: LAU WILLIE [US]; SCHWARTZ CURTIS [US]; SHEFER ADI [US]

Title: Enhancing properties by the use of nanoparticles

Applicant/Assignee: DISALVO ANTHONY L,

Application No.: 10/979365 Applic. Date: 2004-11-01

Abstract: Composite materials comprising nanoparticles functionalized with metals are disclosed. The composite materials may be used in a variety of applications, including in coating compositions, cosmetic and pharmaceutical compositions, absorbent articles, and the like.

Priority: US20030515758P Applic. Date: 2003-10-30

Inventor: DISALVO ANTHONY L [US]; MORDAS CAROLYN J [US]

Title: Shape- adaptable and spectral-selective distributed light sources using passive host medium

Applicant/Assignee: MEDX HEALTH CORP [CA]

Application No.: 11/007597 Applic. Date: 2004-12-09

Abstract: A method of making shape-adaptable and spectral- selective distributed optical radiation sources, in the wavelength range between UV and mid-infrared, for therapeutic treatment using passive host medium containing nanocrystals is disclosed. The spectral output of the distributed optical radiation source is controlled by the nanocrystal size distribution that determines the spectral output of fluorescence radiation originating from these nanocrystals from within the said host medium, which contains the said nanocrystals, under excitation by an external source. The size of nanocrystals, or the size distribution of nanocrystals, incorporated in the host medium is selected based on the radiation spectral output required for therapeutic requirements. The passive host medium, incorporating the said nanocrystals, is made of adaptable, geometrically configurable, material that conforms to any desired shape.

Priority: US20030527521P Applic. Date: 2003-12-09

Inventor: HUBERT MANFRED [CA]; MARTIN STEVEN [CA]; YACOBI BEN G [CA]; BURGMANN THOMAS A [CA]; PASSY PHILIP W [US]

Patent No.: US7202418B2 Issued: 2007-04-10

Title: Flame retardant and smoke suppressant composite high performance support-separators and conduit tubes

Applicant/Assignee: CABLE COMPONENTS GROUP LLC [US]

Application No.: 11/030436 Applic. Date: 2005-01-06

Abstract: The present invention includes a high performance communications cable exhibiting reduced cross-talk of any form between transmission media that includes one or more core support-separators having various shaped profiles which define a clearance to maintain a spacing between transmission media or transmission media pairs. The core may be formed of a conductive or insulative material to further reduce cross-talk and improve other electrical properties as well as reduce flame and smoke spread. The cable and separators are comprised of principally polymer blends that include olefin and/or fluoropolymer and/or chlorofluoropolymer based resins with and without inorganic additive such as nano-clay composites.

These unique blends offer both flame and smoke suppression while maintaining the characteristics necessary to improve electrical performance and allow for severe cost reduction over conventional separators. The specially shaped core support-separators can be either interior to the cable jacket or be employed singularly without the benefit of a jacket and extend along the longitudinal length of the communications cable. Alternatively, with no jacket for cable completion, a portion of the separator wherein a thin layer of material can act as a type of skin for future mechanical protection is provided. The specially shaped core support-separator has both a central region as well as a plurality of shaped sections that extend outward from the central region that are either solid or partially solid, foamed or foamed with a solid skin surface.

In addition, the invention includes the optional incorporation of hollow ducts that can be used to provide optical or metal conductor media either before, during, or after installation of the cable primarily by gas driven means.

Priority: US20040534646P Applic. Date: 2004-01-07

Inventor: GLEW CHARLES A [US]

Title: Delivery of genes encoding short hairpin RNA using receptor-specific nanocontainers

Applicant/Assignee: PARDRIDGE WILLIAM M,

Application No.: 10/800362 Applic. Date: 2004-03-12

Abstract: Receptor-specific nanocontainers are used to deliver a gene that encodes short hairpin RNA to cells having a given receptor. Once inside the cell, the gene expresses short hairpin RNA that includes a nucleotide sequence that is antisense to at least a portion of an oncogene, such as human epidermal growth factor receptor (EGFR) mRNA, or other disease causing nucleotide sequence. The short hairpin RNA is converted, in the cellular cytoplasm, into short RNA duplexes that are effective in deactivating (knocking down) the oncogenic or disease causing gene.

Inventor: PARDRIDGE WILLIAM M [US]; BOADO RUBEN J [US]

Patent No.: US7413800B2 Issued: 2008-08-19

Title: Co-extruded biaxially oriented sealable, peelable film and process for its production

Applicant/Assignee: TERPHANE INC

Application No.: 10/951333 Applic. Date: 2004-09-27

Abstract: A peelable sealable co-extruded film, comprising: i. a skin layer capable of heat sealing against a rim of a container, to itself, or to another film and adapted to be peeled there from and comprising a hot melt adhesive resin

and ii. a core layer underlying said skin layer and comprising crystalline homopolymer polyethylene terephthalate

and a method for the preparation thereof.

Priority: US20040555346P Applic. Date: 2004-03-22

Inventor: WOOD RONALD C JR [US]; VIEIRA MARCOS F [BR]

Patent No.: US7294340B2 Issued: 2007-11-13

Title: Healthcare and cosmetic compositions containing nanodiamond

Application No.: 10/814660 Applic. Date: 2004- 03-30

Abstract: Nanodiamonds can be included in various compositions to take advantage of the ability of nanodiamond to bond with biological materials and to improve mechanical strength. Nanodiamonds can be dispersed in a biologically acceptable carrier to form various nanodiamond compositions. The presence of nanodiamonds can increase binding with many biological materials, making the compositions of the present invention useful for a large variety of purposes such as cleansing, testing and identification of materials, and treatment of adverse conditions. Specific examples of nanodiamond compositions that can be formulated include deodorants, toothpastes, shampoos, antibiotics, dermal strips, DNA test strips, skin cleansers, and the like. Similarly, nanodiamond particles can be included in a cosmetic nanodiamond composition within a cosmetically acceptable carrier.

Cosmetic nanodiamond compositions can include, for example, nail polish, eyeliner, lip gloss, exfoliant, and the like.

Inventor: SUNG CHIEN-MIN [CN]; SUNG MICHAEL [US]; SUNG EMILY [US]

Patent No.: US7517728B2 Issued: 2009-04-14

Title: Semiconductor light emitting devices including a luminescent conversion element and methods for packaging the same

Applicant/Assignee: CREE, INC

Application No.: 11/055194 Applic. Date: 2005-02-10

Abstract: Methods of packaging a semiconductor light emitting device include dispensing a first quantity of encapsulant material into a cavity including the light emitting device. The first quantity of encapsulant material in the cavity is treated to form a hardened upper surface thereof having a selected shape. A luminescent conversion element is provided on the upper surface of the treated first quantity of encapsulant material. The luminescent conversion element includes a wavelength conversion material and has a thickness at a middle region of the cavity greater than proximate a sidewall of the cavity.

Priority: US20040558314P Applic. Date: 2004-03-31; US20040637700P Applic. Date: 2004-12-21

Inventor: LEUNG MICHAEL [US]; COLEMAN THOMAS G [US]; BECERRA MARYANNE [US]

Title: Topical administration of at least one double-stranded RNA oligonucleotide (dsRNA)

Applicant/Assignee: OREAL [FR]

Application No.: US 2004-001085 Applic. Date: 2004-12-02

Abstract: Expression of a messenger RNA which encodes a protein which is expressed by differentiated cells, notably the cells of the skin or appendages thereof, is inhibited by topically administering to said differentiated cells a thus effective amount of at least one double- stranded RNA oligonucleotide, formulated into a topically applicable, physiologically acceptable medium therefor

such regime or regimen is useful for treating a variety of afflictions or conditions, e.g., combating the signs of skin aging, stimulating hair growth or retarding loss thereof, inhibiting cellular proliferation and/or differentiation, etc.

Priority: FR20020006796 Applic. Date: 2002-06-03; WO2003FR01648 Applic. Date: 2003-06-02

Inventor: DURANTON ALBERT [FR]; COLLIN -DJANGONE CHRISTINE [FR]; PRUCHE FRANCIS [FR]; SIMONNET JEAN-THIERRY [FR]

Title: Nano-particles on fabric or textile

Applicant/Assignee: AVAILABLEIP COM

Application No.: 11/064262 Applic. Date: 2005-02-23

Abstract: Systems and methods for fabricating a wash durable material includes forming a substrate having strands with void spaces in the strands and between the strands

filling at least a part of the void spaces with nano-particles

and forming projections on the substrate.

Priority: US20040560053P Applic. Date: 2004-04-06

Inventor: TRAN BAO [US]

Title: Cosmetic compositions containing small magnetic particles

Applicant/Assignee: DEAD SEA LAB LTD

Application No.: 10/519387 Applic. Date: 2004-12-27

Abstract: The present invention present a novel and cost-effective family of cosmetic compositions comprising inter alia small magnetic particles characterized by magnetic field adapted to be topically administrated adjacent to skin surface, absorbed to epidermal upper skin layers and place in a direct contact to the body, usually above pain suffering regions. The present invention also provides the use of the compositions, especially of nano-powders of salts obtained from the Dead Sea, as an external layer of bandages, dressings, compresses or warps, so constantly approached to be in an intimate contact with the patient's skin.

Priority: US20020390370P Applic. Date: 2002-06-24; WO2003IL00529 Applic. Date: 2003-06-23

Inventor: MAOR ZEEV [IL]; ROYZ MICHAEL [IL]

Title: Permeation enhancer comprising genus Curcuma or germacrone for transdermal and topical administration of active agents

Application No.: 11/114537 Applic. Date: 2005-04-26

Abstract: A formulation, method and system for the topical, transdermal or transmucosal administration of a therapeutically effective active agent. Particularly, the invention provides a formulation, system and method for enhancing the permeation or penetration of active agents across the dermal or mucosal surfaces of a mammalian subject. The formulation includes a plant extract of the genus Curcuma of the family Zingiberaceae, a germacrone, or a natural or synthetic constituent thereof, which has been found to increase penetration of the active agent across the dermal or mucosal surface. If desired, a secondary permeation enhancer of a polyalcohol, a monoalkyl ether of diethylene glycol, a tetraglycol, or a mixture thereof can be used for certain active agents for optimal permeation enhancement.

Priority: US20040567037P Applic. Date: 2004-04-30

Inventor: CARRARA DARIO NORBERTO R [CH]; GRENIER ARNAUD [FR]; BESSE CELINE [FR]; ALBERTI INGO [FR]; HENRY LAETITIA [FR]

Title: Human body affinitive lubricating protective and repair gel

Application No.: 10/837585 Applic. Date: 2004-05-04

Abstract:

Inventor: SHIN- CHING SUN [TW]; CHAO-WANG CHIANG [TW]

Patent No.: US7182938B2 Issued: 2007-02-27

Title: Cosmetic formulations comprising ZnO nanoparticles

Applicant/Assignee: BASF AG [DE]

Application No.: 11/074760 Applic. Date: 2005-03-09

Abstract: The present invention relates to the formation of surface treated zinc oxide and titania particles, and in particular zinc oxide and titania nanoparticles, with a siloxane star-graft copolymer coating, comprising a looped and/or linear polymeric structure on a star-graft copolymer coating, on a particle surface to control the interfacial surface interactions between the particle and the oil phase of the cosmetic skin formulation.

Priority: US20040592133P Applic. Date: 2004-07-30; US20040559857P Applic. Date: 2004-04-06

Inventor: ANDRE VALERIE [DE]; BROTZMAN RICHARD W JR [US]

Title: Methods for accurate component intensity extraction from separations-mass spectrometry data

Applicant/Assignee: BIOSPECT INC A CALIFORNIA CORP [US]

Application No.: 10/846996 Applic. Date: 2004-05-13

Abstract: The present invention discloses methods for deconvolving and converting 1D mass spectra to 2D mass spectrum in order to obtain migration time centers and total intensities of the neutral mass envelopes of 2D spectra. The present invention also discloses devices that include a preparation/separation unit coupled to a mass spectrometer unit, and a computer unit capable of deconvolving mass spectra and calculating neutral mass envelopes.

Inventor: AHMED ZULFIKAR [US]; BITTER HANS [US]; BROWN MICHAEL [US]; HELLER JONATHAN C [US]; DONOHO DAVID [US]; QUARATO JIM [US]; BALASINGHAM ARJUNA [US]; DE VALPINE DAVID P [US]

Title: Artificial immune system: methods for making and use

Application No.: 11/116234 Applic. Date: 2005-04-28

Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.

Priority: US20040565846P Applic. Date: 2004-04-28; US20050643175P Applic. Date: 2005-01-13

Inventor: WARREN WILLIAM L [US]; FAHLENKAMP HEATHER [US]; HIGBEE RUSSELL [US]; KACHURIN ANATOLY [US]; LI CONAN [US]; NGUYEN MIKE [US]; PARKHILL ROBERT [US]; SANCHEZ-SCHMITZ GUZMAN [US]; IRVINE DARRELL J [US]; RANDOLPH GWENDALYN J [US]; HACOHEN NIR [US]; TORBETT BRUCE [US]

Title: Metal cluster nano-compounds for treating tumor diseases

Application No.: 10/523081 Applic. Date: 2005-07-28

Abstract: The invention relates to metal cluster nano-compounds of transition metals, which includes a metal nucleus formed from atoms of at least one transition metal and at least one ligand, and including their physiologically compatible salts, derivatives, isomers, hydrates, metabolites and prodrugs, which are suited for the prophylactic and/or therapeutic (curative) treatment of diseases of the human or animal body, particularly of tumor or cancer diseases. To this end, the inventive compounds can, under physiological conditions, interact with the DNA, preferably B-DNA, of the relevant cells.

Priority: DE20021035602 Applic. Date: 2002-08-02; WO2003EP08475 Applic. Date: 2003-07-31

Inventor: SCHMID GUNTER [DE]; KUHN HUBERT [DE]; TSOLI MARIA [DE]

Title: Detection and quantification of prion isoforms in neurodegenerative diseases using mass spectrometry

Applicant/Assignee: ISTA SPA [IT]

Application No.: 10/966012 Applic. Date: 2004-10-15

Abstract: Disclosed are methods, compositions and kits for diagnosing prion-mediated pathological conditions and presence of aberrant prion protein in animal derived products, utilizing mass spectrometry.

Priority: WO2002US12012 Applic. Date: 2002-04-17; US20010284237P Applic. Date: 2001-04-17; US20010284705P Applic. Date: 2001-04-18

Inventor: EVERETT NICHOLAS P [US]; PETELL JAMES K [US]

Title: Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages

Applicant/Assignee: OREAL [FR]

Application No.: 11/202192 Applic. Date: 2005-08-12

Abstract: Inhibitors of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), for example tetrazole, styrylpyrazole, phenylfuran, phenylthiophene, phenylpyrrazole, pyrazolecarboxamide, 2-thioacetamide and azo compounds, are useful for promoting or stimulating pigmentation of the skin and/or skin appendages and/or for preventing and/or for limiting depigmentation and/or whitening of the skin and/or skin appendages, notably for preventing and/or limiting canities.

Priority: FR20030050023 Applic. Date: 2003-02-12; WO2004FR00325 Applic. Date: 2004-02-12

Inventor: MICHELET JEAN-FRANCOIS [FR]; COMMO STEPHANE [FR]

Title: Method of conveying matter into targeted cells in a human body

Application No.: 11/212294 Applic. Date: 2005-08-27

Abstract: A method of conveying matter to targeted cells in a human body, including the steps of providing a predetermined amount of substance desired to be conveyed to the human body, embracing the substance with a predetermined amount of carrier to form a nano-size dosage form and administrating the nano-size dosage form to the human body. The carrier is capable of traveling around the human body through the nervous system of the human body along with the substance desired to be conveyed. The substance to be conveyed includes a wide range of substances such as medication, food supplements, or vitamins. The method conveys matters that are especially useful in curing illnesses or diseases. Even when used alone, the carrier helps curing illnesses or diseases.

Priority: US20040605678P Applic. Date: 2004-08-28

Inventor: YU EUKKI Q [US]

Title: Methods and compositions for the treatment of diseases characterized by pathological calcification

Applicant/Assignee: NANOBAC PHARMACEUTICALS INC

Application No.: 11/102798 Applic. Date: 2005-04-11

Abstract: Methods and compositions are provided which contains preparations of calcium chelators, bisphosphonates, antibiotics, antimicrobial agents, cytostatic agents, calcium ATPase and pyrophosphatase pump inhibitors, calcium phosphate-crystal dissolving agents, agents effective against calcium phosphate- crystal nucleation and crystal growth, and/or a combination of supportive agents and which may be used for treating and or reducing pathological calcifications, the growth of Nanobacterium and calcification -induced diseases including, but not limited to, Arteriosclerosis, Atherosclerosis, Coronary Heart Disease, Chronic Heart Failure, Valve Calcifications, Arterial Aneurysms, Calcific Aortic Stenosis, Transient Cerebral Ischemia, Stroke, Peripheral Vascular Disease, Vascular Thrombosis, Dental Plaque, Gum Disease (dental pulp stones), Salivary Gland Stones, Chronic Infection Syndromes such as Chronic Fatigue Syndrome, Kidney and Bladder Stones, Gall Stones, Pancreas and Bowel Diseases (such as Pancreatic Duct Stones, Crohn's Disease, Colitis Ulcerosa), Liver Diseases (such as Liver Cirrhosis, Liver Cysts), Testicular Microliths, Chronic Calculous Prostatitis, Prostate Calcification, Calcification in Hemodialysis Patients, Malacoplakia, Autoimmune Diseases. Erythematosus, Scleroderma, Dermatomyositis, Antiphospholipid Syndrome, Arteritis Nodosa, Thrombocytopenia, Hemolytic Anemia, Myelitis, Livedo Reticularis, Chorea, Migraine, Juvenile Dermatomyositis, Grave's Disease, Hypothyreoidism, Type 1 Diabetes Mellitus, Addison's Disease, Hypopituitarism, Placental and Fetal Disorders, Polycystic Kidney Disease, Glomerulopathies, Eye Diseases (such as Corneal Calcifications, Cataracts, Macular Degeneration and Retinal Vasculature-derived Processes and other Retinal Degenerations, Retinal Nerve Degeneration, Retinitis, and Iritis), Ear Diseases (such as Otosclerosis, Degeneration of Otoliths and Symptoms from the Vestibular Organ and Inner Ear (Vertigo and Tinnitus)), Thyroglossal Cysts, Thyroid Cysts, Ovarian Cysts, Cancer (such as Meningiomas, Breast Cancer, Prostate Cancer, Thyroid Cancer, Serous Ovarian Adenocarcinoma), Skin Diseases (such as Calcinosis Cutis, Calciphylaxis, Psoriasis, Eczema, Lichen Ruber Planus), Rheumatoid Arthritis, Calcific Tenditis, Osteoarthritis, Fibromyalgia, Bone Spurs, Diffuse Interstitial Skeletal Hyperostosis, Intracranial Calcifications (such as Degenerative Disease Processes and Dementia), Erythrocyte-Related Diseases involving Anemia, Intraerythrocytic Nanobacterial Infection and Splenic Calcifications, Chronic Obstructive Pulmonary Disease, Broncholiths, Bronchial Stones, Neuropathy, Calcification and Encrustations of Implants, Mixed Calcified Biofilms, and Myelodegenerative Disorders (such as Multiple Sclerosis, Lou Gehrig's and Alzheimer's Disease) in humans and animals. The method comprises administering the various classes of compositions of the present invention, which together effectively inhibit or treat the development of calcifications in vivo.

Priority: US2004-891483 Applic. Date: 2004-07-15

Inventor: KAJANDER E O [US]; AHO K M [FI]; CIFTCIOGLU N [US]; MILLICAN B [US]

Title: Methods and compositions for the administration of calcium chelators, bisphosponates and/or citrate compounds and their pharmaceutical uses

Applicant/Assignee: NANOBAC PHARMACEUTICALS INC

Application No.: 11/180921 Applic. Date: 2005-07-14

Abstract: A composition is provided which contains calcium chelators, bisphosphonates, and/or citrate compounds and which may be used for treating and or reducing pathological calcifications, heavy metal poisoning, the growth of Nanobacterium Calcifying Nano-Particles and calcification-induced diseases in humans and animals. The method includes administering a therapeutic composition of calcium chelators, bisphosphonates, and/or citrate compounds which effectively inhibit or treat the development of calcifications in vivo. Typically, the administered composition includes about 0.1-10:1 parts by weight of calcium chelators, bisphosphonates, and/or citrate compounds.

Priority: US20040587869P Applic. Date: 2004-07-15

Inventor: KAJANDER E O [FI]; AHO K M [FI]; CIFTCIOGLU NEVA [US]; MILLICAN B [US]

Title: Short-distance wireless transmission device for driving functions of medical equipment

Application No.: 10/962507 Applic. Date: 2004-10-13

Abstract: A short-distance wireless transmission device for driving functions of medical equipment, the short-distance wireless transmission device includes a data converting module and a signal emitting module integrated in an electronic product. As such, a user can input a control command via the electronic product, by means of the data converting module, the control command is converted into a common format data, and within an effective distance, a control signal is subsequently transmitted by the signal emitting module via a wireless transmission approach to medical equipment having therein a signal receiving module, thereby allowing the user to control and adjust medical equipment provided on his/her body in real time via a portable electronic communication product in the short-distance wireless transmission approach.

Inventor: SHEN YUAN-YAO [TW]

Title: Methods and compositions for the treatment of diseases characterized by calcification and/or plaque formation

Applicant/Assignee: NANOBAC PHARMACEUTICALS INC

Application No.: 11/182076 Applic. Date: 2005-07-15

Abstract: The invention provides methods and compositions that include a nutraceutical supplement, antibiotic, and metal chelating agent that is administered to a patient to treat or prevent pathological calcification and or plaque formation as associated with Nanobacteria Calcifying Nano- Particles and/or diseases caused there-from, The method includes the administration of a therapeutically effective nutraceutical supplement, tetracycline HCL, and ethylenediaminetetraacetic acid calcium di- sodium salt to a patient in order to prevent and treat calcific disease.

Priority: US20040587871P Applic. Date: 2004-07-15

Inventor: KAJANDER E O [US]; AHO K [FI]; CIFTCIOGLU NEVA [US]; MILLICAN H B [US]; MANISCALCO B [US]

Patent No.: US7601331B2 Issued: 2009-10-13

Title: NIR-sensitive nanoparticle

Applicant/Assignee: MASSACHUSSETTS INST OF TECHNOL [SG]

Application No.: 10/985018 Applic. Date: 2004-11-10

Abstract: It is provided a Near Infrared Sensitive (NIR-sensitive) nanoparticle complex comprising a NIR-sensitive nanoparticle and surfactant(s) adsorbed on the nanoparticle, wherein the surfactant is at least one surfactant selected from: wherein X=1-9

Y=0-9

n=0-9

Z=1-9

W=0-9

m=0-9

each of R<1>, R<2>, R<3 >and R<4>, if present, is H, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1- C6 aryl, HS, COOH, NH2 or OH

R<5 >is COOH, NH2 or OH

with the proviso that n+m is <10

(b) an amino acid having the structure in (a), wherein X=1

Y=2

Z=1

W=1

R<1>, R<2 >and R<4 >are not present

R<3 >is NH2

and R<5 >is COOH

or (c) a peptide, wherein the peptide comprise at least one amino acid (b). Further, it is provided a NIR- sensitive nanoparticle complex(es) having biomolecule(s), for example drug(s), loaded on the surfactant (s).

Inventor: CHOW GAN M [SG]; TAN MEI C [SG]; REN LEI [CN]; YING JACKIE Y [SG]

Patent No.: US7473722B2 Issued: 2009-01-06

Title: Polymer-fiber composite building material with bulk and aesthetically functional fillers

Applicant/Assignee: CERAINTEED CORP

Application No.: 10/983389 Applic. Date: 2004-11-08

Abstract: Polymer composite building materials are provided which contain resin, and about 20-75 wt. % fillers and additives, in which the fillers contain at least one bulk filler for reducing the amount of resin needed to make the building material, and at least one aesthetically functional filler for providing the building material with an aesthetic appearance. The bulk filler and the aesthetically functional filler of this embodiment are non-toxic, resistant to microbial attack, and have a Mohs hardness of less than about 5.

Inventor: GUISELIN OLIVIER [US]; KALKANOGLU HUSNU [US]; LE GOFF CHRISTELLE P [FR]

Title: Cosmetic or dermopharmaceutical compositions comprising tyramine derivatives, method for preparing same, and use thereof

Applicant/Assignee: SEDERMA SAS [FR]

Application No.: 10/519118 Applic. Date: 2005-09-29

Abstract: The invention concerns cosmetic or dermopharmaceutical compositions comprising tyramine derivatives and their salts. The invention also concerns the method for preparing same and use thereof for reducing pigmaentation.

Priority: FR20020007965 Applic. Date: 2002-06-26; WO2003FR01950 Applic. Date: 2003-06-25

Inventor: LINTNER KARL [FR]

Patent No.: US7354926B2 Issued: 2008-04-08

Title: Novel Molecules dervied from noraporphine

Applicant/Assignee: SEDERMA SAS

Application No.: 10/525985 Applic. Date: 2005-09-15

Abstract: The invention concerns novel molecules derived from noraporphine, as well as cosmetic and dermopharmaceutical compositions containing one or several of said derivatives, alone or combined with a plant extract, in particular glaucium flavum, and particularly preparations for reducing pigmentation, with anti-ageing effect or for slimming.

Priority: FR20020010810 Applic. Date: 2002-08-30; WO2003FR02400 Applic. Date: 2003-07-29

Inventor: LINTNER KARL [FR]

Title: Cosmetic or dermopharmaceutical compositions containing kombucha

Application No.: 10/523333 Applic. Date: 2005-08-29

Abstract: Cosmetic or dermopharmaceutical compositions which contain kombucha are disclosed. The present invention further relates to the use of kombucha and cosmetic or dermopharmaceutical compositions containing the same, alone or in combination, for the care of the skin, mucosae and skin appendages, and in particular for preventing the signs of endogenous and/or exogenous ageing.

Priority: FR20020009710 Applic. Date: 2002-07-30; WO2003FR02368 Applic. Date: 2003-07-25

Inventor: LINTNER KARL [FR]

Title: Medical apparatus and system for preventing and treating diseases

Application No.: 11/041643 Applic. Date: 2005-01-24

Abstract: Medical apparatus and system are provided for preventing and treating diseases by the medical apparatus comprising body-thing, electronic pulse device, medical magnet slices, herbal medicine gauze pads and nano-micro-biochemical-textile. The medical apparatus is made in various types such as cap, eyeshade, waistband, knee-band, wristband based on different position of human body. The medical apparatus and system are effective and safe for preventing and treating diseases such as headache, migraine, eyestrain, nervosas, insomnia, forgetful, overweight, hypertension, diabetes, cerebral thrombosis, cervical spondylosis, lumbago and seraglio, rheumatoic arthritis, scapulohumeral periarthritis.

Inventor: WAN XUSHAN [US]; WAN LONG [CN]; LIU XIAOZHE [US]

Patent No.: US7300649B2 Issued: 2007-11-27

Title: COSMETIC AND COSMECEUTICAL COMPOSITIONS FOR RESTORATION OF SKIN BARRIER FUNCTION

Applicant/Assignee: GENEPHARM, INC

Application No.: 11/275994 Applic. Date: 2006-02-08

Abstract: Compositions, kits and methods are provided for restoring skin barrier function to skin exposed to environmental elements and/or in a pathological condition. In general, divalent cations such as calcium ions and/or magnesium ions are included in a physiologically acceptable medium. In some embodiments, divalent cations are balanced with monovalent cations such as sodium and potassium ions at appropriate ratios in order to maintain the homeostasis of skin barrier. The compositions, kits and methods can be used as cosmetics, cosmeceuticals or pharmaceuticals for improving skin condition, and preventing or treating dermatological diseases and skin disorders.

Priority: US20050652196P Applic. Date: 2005-02-11

Inventor: TANOJO HANAFI [US]; HUANG XINFAN [US]

Title: Composite materials and particles

Application No.: 11/336819 Applic. Date: 2006-01-23

Abstract: A method or concept for producing a composite material having at least an amphifilic (i.e., surface-active) and polymer component, and the composite material formed thereby, includes providing a mixture of at least one each of polymer and amphifilic compound in a volatile solvent or solvent mixture and providing a phase diagram of the chemical system describing how the components of the chemical system interact in thermodynamic stable phases as a function of temperature, concentration and pressure. The polymer should be a homopolymer, a random block copolymer or a mixture thereof, preferably biodegradable. The amphifilic compound can form a bilayer-containing phase. The solvent is removed from the mixture by a process selected from the phase diagram considering the desired final composite material, whereby a material is formed. The composite material is useful for applications such as encapsulation of therapeutically active components or for applications such as surface coating.

Priority: SE20030001722 Applic. Date: 2003-06-10; WO2004SE00917 Applic. Date: 2004-06-10

Inventor: IMBERG ANNA [SE]

Title: Biological chip

Application No.: 11/107693 Applic. Date: 2005- 04-14

Abstract: A biological chip provided for maintaining the health of a body cell through maintaining an original electrical signal expressed by the body cell, wherein the biological chip comprises a power source, a communication chip, and a biological carrier. The communication chip contains a correcting electrical signal, which is adapted for assisting the unhealthy body cell. The biological carrier forms a communication channel between the communication chip and the unhealthy body cell for transmitting the correcting electrical sign to the unhealthy body cell, so as to restore the unhealthy body cell back to the healthy condition. The correcting electrical signal corrects an unhealthy electrical signal transmitted by the cell without affecting healthy electrical signals transmitted by other healthy cells, such that the correcting electrical signal helps restoring the healthy condition of a cell, healing wounds, curing infections and converting harmful mutated cells to normal body cells, so as to cure diseases such as cancers and AIDS effectively. The biological chip is applied to a body in a transdermal manner such that no ingestion or injection of medication is required.

Inventor: YU EUKKI Q [US]

Patent No.: US7473849B2 Issued: 2009-01-06

Title: Variable diameter conduit tubes for high performance, multi-media communication cable

Applicant/Assignee: CABLE COMPONENTS GROUP LLC

Application No.: 11/408444 Applic. Date: 2006-04-21

Abstract: The present invention describes a conduit tube like structure for high performance, multi-media communications cables with or without support separators that are of varying internal and external dimensions and wall thicknesses that may vary consistantly or randomly and may be spirally or helically wound within or around a high performance, multi-media communications cable to vary the spacing between a high performance, multi-media communications cable and an adjacent communications cables to mitigate alien cross talk as well as the influence of EME/RFI. The conduit tube structures say be hollow, contain communications media, solid, comprised of various shapes, and wrapped with various windings and/or tensions. The final cable assembly may then be jacketed or taped as desired.

Priority: US20050674526P Applic. Date: 2005-04-25

Inventor: GLEW CHARLES A [US]

Patent No.: US7473850B2 Issued: 2009-01-06

Title: High performance, multi-media cable support-separator facilitating insertion and removal of conductive media

Applicant/Assignee: CABLE COMPONENTS GROUP LLC

Application No.: 11/408451 Applic. Date: 2006-04-21

Abstract: The present invention includes a high performance communications cable support-separator that exhibits reduced cross-talk of any form between transmission media that includes one or more core support- separators having various shaped profiles which define a clearance to maintain a spacing between transmission media or transmission media pairs. The cable channels have longitudinal gaps that allow for improved insertion and removal of conductive transmission media to aid in terminating and connecting the transmission media. The cable support-separator channel intermediary may be additionally separated from each other.

Priority: US20050674526P Applic. Date: 2005-04-25

Inventor: GLEW CHARLES A [US]

Patent No.: US7465879B2 Issued: 2008-12-16

Title: Concentric-eccentric high performance, multi-media communications cables and cable support-separators utilizing roll-up designs

Applicant/Assignee: CABLE COMPONENTS GROUP LLC

Application No.: 11/408452 Applic. Date: 2006-04-21

Abstract: The present invention includes a high performance communications cable or cable support-separator and/or jacket that provides reduced cross-talk of any form between transmission media and includes one or more core support-separators having various shaped profiles which define a clearance to maintain spacing between transmission media or transmission media pairs. The core may be formed of a conductive or insulative material to further reduce cross-talk and improve other electrical properties as well as reduce flame and smoke spread. The cable and separators may be comprised of polymer blends that include olefin and/or fluoropolymer and/or chlorofluoropolymer based resins with and without inorganic additives such as nano-clay composites, C60 based compounds, etc.

These unique blends offer both flame and smoke suppression while maintaining the characteristics necessary to improve electrical performance and allow for severe cost reduction compared with conventional separators. Alternatively, with no jacket for cable completion, a portion of the separator wherein a thin layer of material can act as a type of skin for future mechanical protection is provided. The specially shaped core support-separator has both a central region as well as a plurality of shaped sections that extend outward from the central region that are either solid or partially solid, foamed or foamed with a solid skin surface. In addition, the invention includes the optional incorporation of hollow ducts that can be used to provide for insertion of optical or metal conductor media either before, during, or after installation of the cable.

In the case where insertion occurs after installation, the installation primarily utilizes gas driven means.

Priority: US20050674526P Applic. Date: 2005-04-25

Inventor: GLEW CHARLES A [US]

Title: High performance, multi-media communication cable support-separators with sphere or loop like ends for eccentric or concentric cables

Applicant/Assignee: CABLE COMPONENTS GROUP LLC

Application No.: 11/409156 Applic. Date: 2006-04-21

Abstract: The present invention includes a communications cable support-separator that has both a central region as well as a plurality of shaped sections that extend outward from the central region having various shaped profiles on the ends that are either solid or partially solid, foamed or foamed with a solid skin surface and that exhibits reduced cross-talk of any form between transmission media. Included is one or more end profiles which define a clearance to maintain a spacing between transmission media or transmission media pairs. The core may be comprised of principally polymer blends including olefin, fluoropolymer, chlorofluoropolymer based resins or combinations with and without inorganic additive such as nano-clay composites or conductive or insulative material. The specially shaped core support-separators can be either interior to a cable jacket or be employed singularly without the benefit of a jacket and extend along the longitudinal length of the communications cable.

Priority: US20050674526P Applic. Date: 2005-04-25

Inventor: GLEW CHARLES A [US]

Title: Packaging articles, films and methods that promote or preserve the desirable color of meat

Application No.: 11/436159 Applic. Date: 2006-05-17

Abstract: Food packaging articles, food packaging films, and food packaging methods comprising a myoglobin blooming agent that promote or preserve the desirable appearance of food products are provided. The food contact layer of the packaging films comprises a myoglobin blooming agent.

Priority: WO2005US11387 Applic. Date: 2005-04-04; US20040559350P Applic. Date: 2004-04-02

Inventor: SIEGEL DAN G [US]; NELSON KEVIN P [US]

Title: Production and use of a sacrificial mold core for metal casting

Applicant/Assignee: DAIMLER CHRYSLER AG [DE]

Application No.: 11/371448 Applic. Date: 2006-03-09

Abstract: The manufacture and use of sacrificial molds for metal casting, in particular for sacrificial molds of green ceramic. For production of the ceramic cast mold one frequently resorts to slip-casting in which the shaping of the mold is brought about by casting of liquid slip into the original mold. Bubbles or blisters frequently occur in this casting, which in the later mold lead to not tolerable surface and joint faults of the mold. This can only partially be counteracted by employment of so-called boosting and careful pouring. It is thus the task of the invention to provide a process for production of mold cores of slip ceramic for metal casting, in which the problem of bubbles or blisters is at least reduced. The invention is solved by using a porous original mold. This provides the advantage, that enclosed or trapped air bubbles or blisters can escape through the pores of the original mold, while the slip on the basis of its surface tension cannot penetrate into the pores.

Priority: DE200510011019 Applic. Date: 2005-03-10

Inventor: BAUSINGER HOLGER [DE]; LEBBING RALF [DE]; PFEIFER ROLF [DE]

Title: Device and kit for delivery of encapsulated substances and methods of use thereof

Application No.: 11/397864 Applic. Date: 2006-04-05

Abstract: The present invention is of a kit and electricity generating device for delivery of an encapsulated composition or mixture of compositions, including an electricity generating device and at least one composition in an encapsulated carrier vehicle which is contacted or applied to the electricity generating device. In some embodiments the device includes a means for maintaining stability of the encapsulated composition prior to bio-membrane penetration. The present invention also provides methods of use thereof. Furthermore, the present invention provides a device and method for delivering a fixed ratio of compounds from a mixture to a bio-membrane comprising the step of electro-transporting an encapsulated mixture of compounds. Still further, the present invention is of a device and method for delivering each compound of a mixture of compounds to the same penetration depth.

Priority: US20050669001P Applic. Date: 2005-04-07

Inventor: KARMON YORAM [IL]; HAREL NURIT [IL]; MAVOR DANIELA [IL]; SHAHAR MICHAL [IL]

Patent No.: US7259109B2 Issued: 2007-08-21

Title: Electrospray and enhanced electrospray deposition of thin films on semiconductor substrates

Applicant/Assignee: INTEL CORPORATION

Application No.: 10/947016 Applic. Date: 2004-09-22

Abstract: A method of forming a thin film on a substrate to fabricate a microelectronic device, a microelectronic device comprising a thin film deposited according to the method, and a system comprising the microelectronic device. The thin film may include on of a low k thin film, a thin film comprising photoresist, and a sacrificial polymer. The method comprises dispersing a precursor preparation into a spray of charged droplets through subjecting the liquid precursor preparation to electrostatic forces

directing the charged droplets to move toward the substrate

and allowing the charged droplets to generate a beam of gas-phase ions as the charged droplets move toward the substrate. The method further includes directing the gas-phase ions to impinge upon the substrate to deposit the thin film thereon to yield a deposited thin film on the substrate.

Inventor: MEAGLEY ROBERT P [US]

Title: Biocompatible polymer

Application No.: 10/557996 Applic. Date: 2005-11-22

Abstract: The present disclosure relates to a biocompatible polymer composition for an article comprising a surface intended to contact blood, tissue, skin, epithelial layers, wounds, cells in culture fluids, body fluids, dialysis fluids, therapeutic fluids, or mixtures thereof for removal or infusion. The invention also relates to a method for the preparation of an article comprising the biocompatible polymer composition and a use thereof.

Priority: SE20030001546 Applic. Date: 2003-05-23; US20040552764P Applic. Date: 2004-03-12; WO2004SE00804 Applic. Date: 2004-05-24

Inventor: DEPPISCH REINHOLD [DE]; DIETRICH RUTH [DE]; BECK WERNER [DE]; SCHNELL ANDREA [DE]; WITTNER BERND [DE]

Title: Myoglobin blooming agent, films, packages and methods for packaging

Application No.: 11/451968 Applic. Date: 2006-06-12

Abstract: Non-shrink, forming and nonforming thermoplastic webs comprising a myoglobin blooming agent on a food contact surface are useful for packaging fresh meat and other products to fix a desirable color on the surface of the product.

Priority: US2006-413504 Applic. Date: 2006-04-28; WO2005US11387 Applic. Date: 2005-04-04; US20040559350P Applic. Date: 2004-04-02

Inventor: SIEGEL DAN G [US]; BERBERT OTACILIO T [US]; NELSON KEVIN P [US]; POCKAT GREGORY R [US]

Title: Vectorization of dsRNA by cationic particles and use of same on a skin model

Applicant/Assignee: OREAL [FR]

Application No.: 11/436775 Applic. Date: 2006-05-19

Abstract: The present invention relates to vectorization of double stranded RNA oligonucleotides by cationic particles chosen from among surfactant micelles, block or non-block polymer micelles, cationic liposomes and niosomes, cationic oleosomes and cationic nanoemulsions, as well as from among cationic organic or inorganic particles and nanocapsules, and to the use of compositions comprising the association of at least one dsRNA and at least one cationic particle on skin models.

Priority: FR20050051304 Applic. Date: 2005-05-19; US20050689528P Applic. Date: 2005-06-13

Inventor: COLLIN-DJANGONE CHRISTINE [FR]; SIMONNET JEAN-THIERRY [FR]

Title: Biomimetic biosynthetic nerve implant

Applicant/Assignee: TEXAS SCOTTISH RITE HOSPITAL FOR CHILDREN

Application No.: 11/418927 Applic. Date: 2006- 05-05

Abstract: A biomimetic biosynthetic nerve implant (BNI) that uses a hydrogel-based, transparent, multi-channel matrix as a 3-D substrate for nerve repair is disclosed. Novel scaffold- casting devices were designed for reproducible fabrication of grafts containing several micro-conduits, and further tested in vivo using a sciatic nerve animal model and repair of the adult hemitransected spinal cord. At 16 weeks post-injury of the sciatic nerve, empty tubes formed a single nerve cable. In sharp contrast, animals that received the multi-luminal BNI showed multiple nerve cables within the available microchannels, better resembling the multi-fascicular anatomy and ultra structure of the normal nerve.

In the injured spinal cord, the BNI loaded with genetically engineered Schwann cells were able to demonstrate survival of the grafted cells inside the BNI, and robust axonal regeneration through the implant up to 45 days after repair.

Priority: WO2004US38087 Applic. Date: 2004-11-05; US2002-209966 Applic. Date: 2002-08-01; US20030517572P Applic. Date: 2003-11- 05

Inventor: ROMERO-ORTEGA MARIO I [US]; GALVAN-GARCIA PEDRO [US]

Title: Webs with synergists that promote or preserve the desirable color of meat

Applicant/Assignee: CURWOOD INC [US]

Application No.: 11/506322 Applic. Date: 2006-08-18

Abstract: Food packaging articles, food packaging webs, and food packaging methods comprising a myoglobin blooming agent and synergist that promote or preserve the desirable appearance of food products are provided. The food contact layer of the packaging webs may comprise a myoglobin blooming agent and a synergist.

Priority: WO2005US11387 Applic. Date: 2005-04-04; US2006-413504 Applic. Date: 2006-04-28; US2006-436159 Applic. Date: 2006-05- 17; US2006-451968 Applic. Date: 2006-06-12; US20040559350P Applic. Date: 2004-04-02

Inventor: SIEGEL DAN G [US]; NELSON KEVIN P [US]; MICHAUD RYAN A [US]

Title: OPTICALLY CLEAR NANOCOMPOSITES AND PRODUCTS USING NANOSCALE FILLERS

Applicant/Assignee: NANOPRODUCTS CORPORATION

Application No.: 10/426414 Applic. Date: 2003-04-30

Abstract: Methods for preparing nanocomposites that enable films with optical clarity, wear resistance and superior functional performance. Nanofillers and a substance having a polymer are mixed. Both low-loaded and highly-loaded nanocomposites are included. Nanocomposite films may be coated on substrates.

Priority: US2001-790036 Applic. Date: 2001-02-20; US1998-083893 Applic. Date: 1998-05-22; US1996-739257 Applic. Date: 1996-10-30; US1996-730661 Applic. Date: 1996-10-11; US1996-706819 Applic. Date: 1996-09-03; US2001-753806 Applic. Date: 2001-01-03; US1998-074534 Applic. Date: 1998-05-07; US1996-707341 Applic. Date: 1996-09-03; US19970049077P Applic. Date: 1997-06-09; US19970069935P Applic. Date: 1997-12-17; US19980079225P Applic. Date: 1998-03-24

Inventor: YADAV TAPESH [US]; KOSTELECKY CLAYTON [US]

Title: Slimming cosmetic composition

Applicant/Assignee: SEDERMA SAS [FR]

Application No.: 10/557616 Applic. Date: 2004-05-19

Abstract: Cosmetic or dermopharmaceutical compositions containing, in a dermatologically acceptable carrier, at least one diterpene among: cafestol, kahweol and chemical derivatives are useful for slimming treatments including prevent and/or treat cellulite or orange peel and/or to refine contours of the face, skin firming, to reduce the steatomery of the thighs, to decrease the volume/fatty overload of the spare tire at the hips, to reduce "love handles", both on men and women.

Priority: FR20030006063 Applic. Date: 2003-05-20; JP20040052321 Applic. Date: 2004- 02-26; WO2004IB50755 Applic. Date: 2004-05-19

Inventor: LINTER KARL [FR]; MAS CHAMBERLIN CLAIRE [FR]

Title: Methods and compositions for the treatment of diseases characterized by calcification and/or plaque formation

Applicant/Assignee: NANOBAC PHARMACEUTICALS INC

Application No.: 11/544048 Applic. Date: 2006-10-06

Abstract: The invention provides methods and compositions that include a nutraceutical supplement, antibiotic, and metal chelating agent that is administered to a patient to treat or prevent pathological calcification and or plaque formation as associated with Nanobacteria Calcifying Nano-Particles and/or diseases caused there-from, The method includes the administration of a therapeutically effective nutraceutical supplement, tetracycline HCL, and ethylenediaminetetraacetic acid calcium di-sodium salt to a patient in order to prevent and treat calcific disease.

Priority: US2005-182076 Applic. Date: 2005-07-15; US20040587871P Applic. Date: 2004-07-15

Inventor: KAJANDER E O [US]; AHO K [FI]; CIFTCIOGLU NEVA [US]; MILLICAN H B [US]; MANISCALCO B [US]

Title: Multiribbon nanocellulose as a matrix for wound healing

Applicant/Assignee: UNIV TEXAS [US]

Application No.: 11/513564 Applic. Date: 2006-08-31

Abstract: The present invention includes compositions and methods for the integration of a non-allergenic nanocellulose into a wound bed. The composition may be formed into a wide variety of implants, e.g., a suture, a sheet, a compress, a bandage, a band, a prosthesis, a fiber, a woven fiber, a bead, a strip, a clasp, a prosthesis, a catheter, a screw, a bone plate, a pin, a bandage or combinations thereof.

Priority: US20050712951P Applic. Date: 2005-08-31

Inventor: BROWN R M JR [US]; CZAJA WOJCIECH [US]; JESCHKE MARC [US]; YOUNG DAVID J [US]

Title: Histone hyperacetylating agents for promoting wound healing and preventing scar formation

Application No.: 10/843025 Applic. Date: 2004-05-10

Abstract: A method for promoting wound healing and preventing scar formation in a variety of wounds in skin, mucosa, and cornea. The method comprises administering a therapeutically effective amount of a histone deacetylase inhibitor or a hyperacetylating agent. The histone deacetylase inhibitor or hyperacetylating agent is capable of stimulating multiple cytokines/growth factors in the early phase of wound healing, and suppressing fibrogenic cytokines/growth factors in the late phase of tissue remodeling in the wound site, and is useful in promoting epithelial cell re-growth and reducing excessive collagen accumulation, which results in rapid wound closure with reduced scaring.

Priority: US2002-205738 Applic. Date: 2002-07-25

Inventor: CHUNG YIH-LIN [TW]

Title: Assessment and control of acoustic tissue effects

Applicant/Assignee: GEORGIA TECH RES INST

Application No.: 11/556074 Applic. Date: 2006-11-02

Abstract: A method for reversibly, or irreveribly, altering the permeability of cells, tissues or other biological barriers, to molecules to be transported into or through these materials, through the application of acoustic energy, is enhanced by applying the ultrasound in combination with means for monitoring and/or implementing feedback controls. The acoustic energy is applied directly or indirectly to the cells or tissue whose permeability is to be altered, at a frequency and intensity appropriate to alter the permeability to achieve the desired effect, such as the transport of endogenous or exogenous molecules and/or fluid, for drug delivery, measurement of analyte, removal of fluid, alteration of cell or tissue viability or alteration of structure of materials such as kidney or gall bladder stones. In the preferred embodiment, the method includes measuring the strength of the acoustic field applied to the cell or tissue at the applied frequency or other frequencies, and using the acoustic measurement to modify continued or subsequent application of acoustic energy to the cell or tissue. In another preferred embodiment, the method further includes simultaneously, previously, or subsequently exposing the cell or tissue to the chemical or biological agent to be transported into or across the cell or tissue. In another preferred application, the method includes removing biological fluid or molecules from the cell or tissue simultaneously, previously or subsequently to the application of acoustic energy and, optionally, assaying the biological fluid or molecules.

Priority: US1999-229226 Applic. Date: 1999-01-12; US19980071240P Applic. Date: 1998-01-12; US19980085304P Applic. Date: 1998-05-13

Inventor: PRAUSNITZ MARK R [US]; LIU JIN [US]; LEWIS THOMAS N [US]

Title: Thiamin based insect repellant

Applicant/Assignee: VIOLET FIRE LLC

Application No.: 11/520253 Applic. Date: 2006-09-13

Abstract: The present invention provides a topical application of thiamin to human skin or mammalian coats to provide effective insect repellency. Any commercially available thiamin compounds such as thiamin hydrochloride or thiamin mononitrate can be combined with a pharmaceutically or cosmetically acceptable carrier for preparing a composition for topical application. This composition and method of application can further be combined with sun-block or sunscreen agents to provide protection against insects as well as the harmful effects of UV radiation. This composition may also contain botanical oils or extracts to mask the thiamin odor and provide repellant synergy.

Priority: US20050729690P Applic. Date: 2005-10-24

Inventor: SPIEGEL LAWRENCE S [US]; SPIEGEL MARY A [US]

Title: Compositions for administering RNAIII-inhibiting peptides

Application No.: 11/430091 Applic. Date: 2006-05-09

Abstract: Compositions comprising RIP are advantageously formulated in compositions allowing sustained release and protection from degradation, and improved therapeutic efficacy. To that end, RIP compositions may be delivered to the skin or mucosal membranes as a salve or the like. Alternatively or additionally, RIP compositions may be administered in polymeric nanoparticle carriers, which may be biodegradable. Such formulations are compatible with oral administration. The nanoparticle may accommodate a composition comprising a RIP and at least one other antimicrobial agent, e.g., an antibiotic or an antimicrobial peptide. The nanoparticle further may comprise a coating or moiety, such as an antibody or fragment thereof, to assist in cell targeting.

Priority: US20050679516P Applic. Date: 2005-05-10

Inventor: BALABAN NAOMI [US]; BRAUNSTEIN JOEL [US]

Title: ADHESIVE MATERIAL AND METHOD OF USING SAME

Applicant/Assignee: L & L PRODUCTS INC [US]

Application No.: 11/552331 Applic. Date: 2006-10-24

Abstract: An adhesive and/or activatable (e.g., heat expandable and/or curable) material and articles incorporating the same are disclosed. The material includes an epoxy resin, an epoxy/elastomer hybrid or reaction product or both

a blowing agent, a curing agent or both

and optionally, a filler.

Priority: US20050732291P Applic. Date: 2005-11-01

Inventor: HABLE CHRISTOPHER [US]; MADAUS BRANDON [US]

Title: Tripeptides and derivatives thereof for cosmetic application in order to improve skin structure

Application No.: 10/555994 Applic. Date: 2004-05-07

Abstract: The invention relates to compounds and to the cosmetically acceptable salts thereof, which correspond to general formula (I), wherein: R<1 >represents H, -C(O)- R<6>, -SO2-R<6 >or -C(O)-XR<6>

R<2 >and R<4>, independent of one another, represent (CH2)n-NH2 or (CH2)3-NHC(NH)NH2

n equals 1 4

R<3 >represents linear or branched C1-C4 alkyl that is optionally substituted by hydroxy

R<5 >and R<6>, independent of one another, represent hydrogen, optionally substituted (C1-C24) alkyl, optionally substituted C2-C24 alkenyl, optionally substituted phenyl, optionally substituted phenyl-C1-C4 alkyl or 9-fluorenyl-methyl

X represents oxygen (-O-) or -NH-

or XR<5 >with X=O also represents the esters of a-tocopherol, tocotrienol or retinol, with the provision that R<1 >and R<5 >do not represent hydrogen and X does not represent oxygen at the same time. The invention also relates to the production of the compounds of general formula (I) and to a cosmetically active composition that contains at least one compound of formula (I).

Priority: CH20030000807 Applic. Date: 2003-05-08; WO2004CH00278 Applic. Date: 2004-05-07

Inventor: ZIEGLER HUGO [CH]; HELDI MARC [DE]; IMFELD DOMINIK [CH]

Title: Biomimetic biosynthetic nerve implant

Applicant/Assignee: TEXAS SCOTTISH RITE HOSPITAL FOR CHILDREN

Application No.: 11/418927 Applic. Date: 2006-05-05

Abstract: A biomimetic biosynthetic nerve implant (BNI) that uses a hydrogel-based, transparent, multi-channel matrix as a 3-D substrate for nerve repair is disclosed. Novel scaffold-casting devices were designed for reproducible fabrication of grafts containing several micro-conduits, and further tested in vivo using a sciatic nerve animal model and repair of the adult hemitransected spinal cord. At 16 weeks post-injury of the sciatic nerve, empty tubes formed a single nerve cable. In sharp contrast, animals that received the multi-luminal BNI showed multiple nerve cables within the available microchannels, better resembling the multi-fascicular anatomy and ultra structure of the normal nerve.

In the injured spinal cord, the BNI loaded with genetically engineered Schwann cells were able to demonstrate survival of the grafted cells inside the BNI, and robust axonal regeneration through the implant up to 45 days after repair.

Priority: WO2004US38087 Applic. Date: 2004-11-05; US2002-209966 Applic. Date: 2002-08-01; US20030517572P Applic. Date: 2003-11-05

Inventor: ROMERO-ORTEGA MARIO I [US]; GALVAN- GARCIA PEDRO [US]

Title: Method for distributing a myoglobin-containing food product

Application No.: 11/584164 Applic. Date: 2006-10- 20

Abstract: A method of distributing or commercializing fresh meat having the general steps of butchering a slaughtered animal into a plurality of retail cuts

packaging the retail cuts into a plurality of articles wherein each article comprises a polymeric oxygen barrier film having a transparent portion in contact with at least a portion of the fresh meat product

transporting the packaged article to a retail outlet, wherein the packaged article is adapted for retail display and sale without removing the polymeric film and wherein the fresh meat product has a desirable appearance especially a desirable red color e.g. having an "a*" value of at least about 15 for the fresh beef product or of at least about 6 for a fresh pork or fresh poultry product and the color is maintained for at least five days and up to four weeks or more after display.

Priority: US20040559350P Applic. Date: 2004-04-02; US2006-523953 Applic. Date: 2006-09-20; US2006-506322 Applic. Date: 2006-08- 18; US2006-451968 Applic. Date: 2006-06-12; US2006-436159 Applic. Date: 2006-05-17; US2006-413504 Applic. Date: 2006-04-28; WO2005US11387 Applic. Date: 2005-04-04

Inventor: SIEGEL DAN G [US]; NELSON KEVIN P [US]; POCKAT GREGORY R [US]; SCHELL THOMAS A [US]; BERBERT OTACILIO T [US]; MICHAUD RYAN A [US]; MENGEL MATTHEW L [US]; LATREILLE DOUGLAS M [US]

Title: SYSTEMS AND METHODS FOR SELECTION AND MAINTENANCE OF HOMOGENEOUS AND PLURIPOTENT HUMAN EMBRYONIC CELLS

Applicant/Assignee: PENN STATE RES FOUND

Application No.: 11/557791 Applic. Date: 2006-11-08

Abstract: A number of human disorders are characterized by degeneration or loss of specific cells, resulting in pathology associated with reduction or absence of cell function. Such diseases include neurodegenerative diseases and diabetes. Methods are described for obtaining a substantially homogeneous population of undifferentiated human embryonic stem cells including incubating a population of human embryonic stem cells with an amount of a selection agent. The selection agent is effective to reduce or eliminate differentiated embryonic stem cells from the population of cells such that a substantially homogeneous population of undifferentiated human embryonic stem cells is obtained. The substantially homogeneous population of undifferentiated embryonic stem cells may be produced without use of feeder cells.

Priority: US20050734862P Applic. Date: 2005-11-09

Inventor: SALLI UGAR [US]; KESTER MARK [US]; VRANA KENT E [US]

Patent No.: US7400789B2 Issued: 2008-07-15

Title: METHOD, SYSTEM AND MODULE FOR MONITORING A POWER GENERATING SYSTEM

Applicant/Assignee: GENERAL ELECTRIC COMPANY

Application No.: 11/468162 Applic. Date: 2006-08-29

Abstract: A sensing module positioned about an optical fiber cable having a long axis. The optical fiber includes a core that transmits light through the optical fiber cable. The sensing module includes a first short- period fiber grating positioned about the core. A second short-period fiber grating is positioned about the core and at a distance along the long axis with respect to the first short-period fiber grating. At least one of a long-aperiod fiber grating and a long-period fiber grating is positioned between the first short-period fiber grating and the second short-period fiber grating. A fiber cladding is positioned around the long-period grating and/or the long-aperiod grating of the sensing module. A sensing skin is positioned about the fiber cladding and includes a chemical gas active material.

Priority: US2005-284595 Applic. Date: 2005-11-22

Inventor: XIA HUA [US]; DENG KUNG-LI J [US]; MCCARTHY KEVIN T [US]; TAWARE AVINASH V [US]

Title: Pulsimeter sensor using magnetic thin films

Applicant/Assignee: SANGJI UNIVERSITY INDUSTRY ACA [KR]

Application No.: 11/583580 Applic. Date: 2006-10-19

Abstract: The present invention relates to a noninvasive medical pulsimeter sensor using magnetic thin films. By forming a pulse-sensing part array with magnetic sensors such as GMR devices, MTJ devices and the likes, over the skin-contacting part which consists of a magnetic material, the present invention increases the integrity of sensors, minimizes the time for searching the pulse and it is applicable widely to portable pulsimeters and the likes.

Priority: KR20050098677 Applic. Date: 2005-10-19

Inventor: LEE SANG S [KR]; HWANG DO G [KR]; KIM KI W [KR]; KIM SUN W [KR]; KIM HYEON H [KR]

Title: Double- stranded RNA oligonucleotides which inhibit tyrosinase expression

Applicant/Assignee: OREAL [FR]

Application No.: 11/524315 Applic. Date: 2006-09-21

Abstract: Novel double-stranded RNA oligonucleotides are useful for decreasing tyrosinase expression, have cosmetic and/or pharmaceutical applications, for example are useful skin depigmenting or anti-browning agents, and can be associated with cationic particles less than or equal to 1 mum in size, having a zeta potential of from 10 to 80 mV.

Priority: FR20050009658 Applic. Date: 2005-09-21

Inventor: COLLIN-DJANGONE CHRISTINE [FR]; SIMONNET JEAN-THIERRY [FR]

Title: Methods and compositions for the detection of calcifying nano-particles, identification and quantification of associated proteins thereon, and correlation to disease

Application No.: 11/299328 Applic. Date: 2005-12-09

Abstract: Disclosed are methods and compositions for detecting, analyzing and assessing the significance of calcifying nano-particles. The disclosed methods and compositions generally involve detecting one or more proteins present on a calcifying nano-particle. It has been discovered that particular proteins become associated with calcifying nano-particles. This association provides a means for detecting, classifying, analyzing, categorizing, and assessing calcifying nano-particles. Detecting particular proteins while associated with a calcifying nano-particle can be used to indicate the presence and type of calcifying nano-particle, which can be used to indicate the presence of, or disposition to, diseases or conditions. Multiple proteins on a calcifying particle can be detected. The presence or absence of particular proteins and the pattern of the presence and absence of particular proteins can be used to indicate the presence and type of calcifying nano-particle.

Inventor: KAJANDER E O [US]; AHO KATJA M [FI]; CIFTCIOGLU NEVA [US]

Title: Therapeutic molecules

Applicant/Assignee: UNIV DEAKIN [AU]

Application No.: 10/545099 Applic. Date: 2004-02-10

Abstract: The present invention relates generally to a ligand for a protein associated with modulating obesity, diabetes and metabolic energy levels in animals including humans. More particularly, the present invention provides a ligand of the protein, Beacon, and its homologs. The identification of a Beacon ligand permits the identification of agents which agonize or antagonize the Beacon-ligand interaction and, hence, the development of therapeutic molecules useful in modulating obesity, diabetes and/or energy imbalance.

Priority: US20030446191P Applic. Date: 2003-02-10; WO2004AU00147 Applic. Date: 2004-02-10

Inventor: COLLIER GREG [AU]; WALDER KEN [AU]; KERR-BAYLES LYNDAL [AU]

Title: Nano-sized particles, processes of making, compositions and uses thereof

Applicant/Assignee: UNIV COLUMBIA [US]

Application No.: 11/451251 Applic. Date: 2006-06-12

Abstract: The present invention describes methods for preparing high quality nanoparticles, i.e., metal oxide based nanoparticles of uniform size and monodispersity. The nanoparticles advantageously comprise organic alkyl chain capping groups and are stable in air and in nonpolar solvents. The methods of the invention provide a simple and reproducible procedure for forming transition metal oxide nanocrystals, with yields over 80%. The highly crystalline and monodisperse nanocrystals are obtained directly without further size selection

particle size can be easily and fractionally increased by the methods. The resulting nanoparticles can exhibit magnetic and/or optical properties. These properties result from the methods used to prepare them. Also advantageously, the nanoparticles of this invention are well suited for use in a variety of industrial applications, including cosmetic and pharmaceutical formulations and compositions.

Priority: WO2004US41141 Applic. Date: 2004-12-09; US20030528667P Applic. Date: 2003-12-11

Inventor: O'BRIEN STEPHEN [US]; YIN MING [US]

Title: Methods and compositions for protein-hydroxy apatite complexes and their application in testing and modulating immunological system including a novel in vitro test for the detection of antibodies against calcium binding protein-hydroxy apatite complexes

Application No.: 11/491519 Applic. Date: 2006-07-24

Abstract: The invention relates to methods and compositions for the manufacture and use of novel hydroxy apatite (HA) -calcium binding protein (CaBP) complexes (CaBP-HA complex) that are useful as antigen preparations for immunological assays for the diagnosis, prognosis, and monitoring of mammalian diseases. The CaBP-HA complexes may be manufactured using synthetic HA that is subjected to serum proteins or by harvesting nanobacteria (NB), also called calcifying nano-particles (CNP), from a mammal. The hydroxy apatite is prepared by incubation with appropriate proteins resulting in conformational changes in said bound proteins. Secondary conformational changes occur when said CaBP-HA complex is subjected to enzymes such as transglutaminase thereby creating covalently bound neoepitopes. The CaBP-HA complex may also contain lipopolysaccharide binding protein (LPSBP) providing for anti-CaBP-LPSBP-HA antibodies detection indicative of disease. Detection of anti-CaBP-HA antibodies in a mammal is via enzyme linked immunosorbent assay.

Priority: US2005-268727 Applic. Date: 2005-11-08; US20040625572P Applic. Date: 2004-11-08

Inventor: KAJANDER E O [US]; CIFTCIOGLU NEVA [US]; AHO KATJA M [FI]

Title: Liposomal Nanowater-Containing Patch-Type Nanodermal Gel for Transdermal Delivery and Method for Preparing the Same

Applicant/Assignee: SPHERE TECH CO LTD [KR]

Application No.: 11/425260 Applic. Date: 2006-06-20

Abstract: Disclosed herein is a patch-type nanodermal gel including liposomal nanowater, which can deliver cosmetically active substances, such as those functioning to moisturize the skin, into and through the skin stably and effectively. The patch-type cosmetic composition for transdermal deliver, based on nanodermal gel, comprises nanowater in an amount from 0.01 to 80.0% by weight

a skin-compatible polymer in an amount from 0.01 to 10.0% by weight

and a polyhydric alcohol in an amount from 5.0 to 20.0% by weight, based on the total weight of the nanodermal gel.

Priority: KR20050131131 Applic. Date: 2005-12-28

Inventor: JEON JONG T [KR]; KIM YOUNG J [KR]; KIM JU Y [KR]

Title: Highly conductive composites for fuel cell flow field plates and bipolar plates

Application No.: 11/324370 Applic. Date: 2006-01-04

Abstract: This invention provides a fuel cell flow field plate or bipolar plate having flow channels on faces of the plate, comprising an electrically conductive polymer composite. The composite is composed of (A) at least 50% by weight of a conductive filler, comprising at least 5% by weight reinforcement fibers, expanded graphite platelets, graphitic nano-fibers, and/or carbon nano-tubes

(B) polymer matrix material at 1 to 49.9% by weight

and (C) a polymer binder at 0.1 to 10% by weight

wherein the sum of the conductive filler weight %, polymer matrix weight % and polymer binder weight % equals 100% and the bulk electrical conductivity of the flow field or bipolar plate is at least 100 S/cm. The invention also provides a continuous process for cost-effective mass production of the conductive composite-based flow field or bipolar plate.

Inventor: JANG BOR Z [US]; ZHAMU ARUNA [US]; SONG LULU [US]

Title: Stabilized derivatives of ascorbic aicd

Applicant/Assignee: TAGRA BIOTECHNOLOGIES LTD [IL]

Application No.: 10/553757 Applic. Date: 2004-04-21

Abstract: Ascorbic acid derivatives of the general formula 1: wherein R<1> is a C2-C22 acyl group, an amino acid group, or a C1-C17 alkyl group

R<2> is ammonium or a metal cation

and each of R<3> or R<4>, independently, is hydrogen, a C2-C22 acyl group, an amino acid residue, or a C1-C17 alkyl group, are more stable than ascorbic acid and can be used as a source of vitamin C in pharmaceutical, nutraceutical and cosmetic compositions.

Priority: US20030464097P Applic. Date: 2003-04-21; WO2004IL00343 Applic. Date: 2004-04-21

Inventor: KVITNITSKY EMMA [IL]; BELAKHOV VALERY [IL]; BABTSOV VLADIMIR [IL]; SHAPIRO VURY [IL]

Title: Integrated Circuit Device

Application No.: 11/381348 Applic. Date: 2006-05-02

Abstract: A commercially mass-produced, integrated circuit including: a solid substrate of one conductivity type

at least one solid material pocket of a different conductivity type having a side surface and positioned on a selected top surface of the substrate to thereby form a signal- translating, electronic rectifying barrier between the at least one solid material pocket and the selected top surface of the substrate

and a solid state material region adjoining the substrate, the electronic rectifying barrier, and the side surface of the at least one solid material pocket

wherein next to the electronic rectifying barrier the solid state material region has a lateral dimensional accuracy of better than a few hundred atomic layers.

Priority: US2004-759081 Applic. Date: 2004-01-20; US1995-483938 Applic. Date: 1995-06-07

Inventor: LI CHOU H [US]

Title: Healthcare and cosmetic compositions containing nanodiamond

Application No.: 11/640136 Applic. Date: 2006-12-14

Abstract: Nanodiamonds can be included in various compositions to take advantage of the ability of nanodiamond to reduce or prevent the formation of free radicals through administering the particles to a subject. Nanodiamonds can be administered through a variety of means to a tissue area of the subject, thus reducing or preventing the formation of free radicals and reducing the signs of ageing. The nanodiamonds may be incorporated into a composition that includes a variety of components including biologically or cosmetically acceptable carriers, dispersants, and additional active ingredients.

Priority: US2004-814660 Applic. Date: 2004-03-30

Inventor: SUNG CHIEN-MIN [TW]

Title: Stimulating galvanic or slow AC current for therapeutic physiological effects

Application No.: 11/651931 Applic. Date: 2007-01-10

Abstract: Basically, the present invention is directed to a new and improved system for the therapeutic use of currents which includes conducting direct electrical current through the skin of a body being treated, and periodically reversing the electrical current and conducting the current through the skin in the opposite direction, to effectively deliver very low frequency AC current, substantially in the critical range of approximately 0.0027 Hz to 20 Hz. It has been discovered that, within this substantially critical frequency window between approximately six minutes per full cycle and approximately ten cycles per second, a dramatic cancellation of skin damaging ions takes place. At frequencies higher than approximately 20 Hz, the effect is to diminish its DC-like blood stimulation. At frequencies lower than approximately 0.0027 Hz, the risk of skin injury increases substantially. It is well known that the positive electrode unfortunately produces skin damaging hydrochloric acid. Likewise, the negative electrode unfortunately also produces skin damaging sodium hydroxide. However, within the aforementioned frequency range of the present invention, either polarity stimulates blood circulation, but also cancels the undesired skin damaging ions with the reverse portion of the electrical cycle. The reason for neutralization of the harsh injury producing chemicals, i.e., hydrochloric acid and sodium hydroxide, is that both of these chemicals require a finite period of time on the skin to cause damage. Hence, these damaging chemicals are made to cancel each other before damage takes place, by critical frequency selection, in accordance with the invention, of the AC driving signal. Therefore, optimization of a long sought electrotherapeutic device with reduced side effects has been achieved. Another use of the safe AC currents cited above and/or a DC signal with charged membranes preventing injury is its application to wound healing. The conductive electrodes for these devices may take either of two forms, i.e., one may be non-metallic carbon-filled silicone or, preferably of powdered carbon particles. A second form may be a metallic electrode preferably of aluminum, copper, zinc and/or magnesium as examples of metallic electrodes but not necessarily limited to these metals. These metals are preferably in powdered form and contained within a porous membrane with a small opening to attach a conductive lead to a battery source. Still other applications of the innovative use in electrotherapy of charged membranes and/or powdered metal electrodes is its use for drug delivery and diagnostic purposes. For instance, a membrane enclosed stainless steel powdered negative electrode may be used in the pickup probe for glucose detection. Charged membranes would surround the probe as an intervenor between skin and the electrode.

Priority: US20060772762P Applic. Date: 2006-02- 13

Inventor: TAPPER ROBERT [US]

Title: Cosmetic Compositions Comprising Sub-micron Boron Nitride Particles

Applicant/Assignee: GEN ELECTRIC [US]

Application No.: 11/554004 Applic. Date: 2006-10-28

Abstract: A cosmetic composition for use on hair, skin or nails, containing a safe and effective amount of boron nitride powder has been found which improves the appearance of skin by blurring lines and wrinkles while at the same time providing coverage of age spots, blemishes and other discolorations.

Priority: US20060777917P Applic. Date: 2006-03- 01

Inventor: BUTTS MATTHEW [US]; SINHA MOITREYEE [US]; GENOVESE SARAH ELIZABETH [US]; YAMADA MASAKO [US]

Title: MULTIPHASIC BIOFUNCTIONAL NANO-COMPONENTS AND METHODS FOR USE THEREOF

Application No.: 11/763842 Applic. Date: 2007-06-15

Abstract: Multiphasic nano-components (MPNs) having at least two phases and at least one active ingredient are provided. The MPNs can be used in various methods for medical diagnostics or with pharmaceutical, personal care, oral care, and/or nutritional compositions, for example, in oral care, hair, or skin products. The MPNs can be designed to have targeted delivery within an organism, while providing controlled release systems or combining incompatible active ingredients. Further, the MPNs can be used as biomedical coatings (such as anti-microbial coatings), or anti- corrosive coatings, bioimaging probes with combined diagnostic and therapeutic use, and fragrance release systems, among others. The MPNs can be formed by electrified jetting of polymers.

Priority: US2005-272194 Applic. Date: 2005-11-10; US20060814706P Applic. Date: 2006-06-16; US20040626792P Applic. Date: 2004-11-10; US20050651288P Applic. Date: 2005-02-09

Inventor: LAHANN JOERG [US]

Title: Combined ultrasonic imaging and spectroscopic molecular analysis

Applicant/Assignee: KONINKL PHILIPS ELECTRONICS NV [NL]

Application No.: 11/570444 Applic. Date: 2005-06-13

Abstract: The invention provides an apparatus for combined imaging and analyzing of a biological structure by means of ultrasonic and spectroscopic techniques. The inventive diagnostic apparatus is adapted for simultaneous acquisition of ultrasonic echo signals and surface enhanced Raman spectroscopic signals. The invention makes particular use of a contrast agent that on the one hand provides enhanced reflection efficiency for ultrasonic echo signals and on the other hand enables surface enhanced Raman spectroscopy. The contrast agent comprises conventional microbubbles as well as solid metal nano-particles or combinations thereof. The invention therefore effectively provides non-invasive in vivo analysis of blood as well as detection and visualization of a blood flow.

Priority: EP20040102767 Applic. Date: 2004-06 -17; WO2005IB51943 Applic. Date: 2005-06-13

Inventor: LUCASSEN GERALD [NL]; WILLARD NICO [NL]; NEERKEN SIEGLINDE [NL]; VAN BOMMEL TIES [NL]

Patent No.: US7449200B2 Issued: 2008-11-11

Title: Nanoparticles for protein/peptide delivery and delivery means

Applicant/Assignee: GP MEDICAL, INC,

Application No.: 11/405066 Applic. Date: 2006-04-17

Abstract: The invention discloses the biodegradable nanoparticle for use in nanoparticle projectile bombardment as a carrier for administering proteins or peptides to an animal subject. The nanoparticles are composed of positively charged shell substrate, negatively charged core substrate with encapsulated bioactive agents of proteins or peptides.

Inventor: SUNG HSING-WEN [TW]; CHEN MEI-CHIN [TW]; LEE PO-WEI [TW]; TU HOSHENG [US]

Title: Secure nano- mask

Applicant/Assignee: NANO IND PTE LTD I [SG]

Application No.: 11/638124 Applic. Date: 2006-12-13

Abstract: A face mask made of woven or non-woven material that accommodates the anatomical features of the face. It has a nose recess or nose-locating space, extended chin space and close fitting cheek areas, for use in medical environments or for general public use. The mask has been developed with innovations that provide security to the wearer by its to the fitting the face particularly without moving upwards or downwards when moving the jaw. This is unlike all other masks tested which either move upwards to reveal the mouth or slide downward to reveal the nostrils due to the movement of the jaw and face when talking or coughing etc. The stability and secure fit to the face is achieved by following the anatomical configuration of the face and by the positioning of the slightly elastic holding straps-the upper one is positioned level with the upper nose to the top of the ear and the lower strap from the mid point of the mask to under the ear-the straps form a loop around the ear. The forces and vectors of the whole mask are directed around the balance point of the mask such that any the movement of the mask in one direction is countered by forces in the other. Furthermore the mask provides protection against cross-contamination and infection by incorporating a nanotechnology anti-microbial component that holds and kills membrane-bound organisms, as well as protecting the wearer against pollen and similar allergens.

Priority: TW20060118019 Applic. Date: 2006-05-19

Inventor: CHIAM KIA CHEE [SG]

Patent No.: US7662929B2 Issued: 2010-02-16

Title: Modulation of Hyaluronan Synthesis and Degradation in the Treatment of Disease

Applicant/Assignee: ALCHEMIA ONCOLOGY LTD [AU]

Application No.: 10/574903 Applic. Date: 2004-10-11

Abstract: The present invention provides compositions and methods for modulating the expression of Hyaluronan (HA). In particular, this invention relates to compounds, which hybridize with nucleic acid molecules encoding hyaluronan synthase (HAS), particularly HAS isoforms HAS1, HAS2 and HAS3. These compounds may range in size from oligonucleotides to full length sequences. Such compounds are exemplified to modulate proliferation, such as cancer and inflammatory disorders, such as arthritis. It will be understood, however, that the compounds can be used for any other condition in which HA is involved.

Priority: AU20030905551 Applic. Date: 2003-10-10; AU20030906658 Applic. Date: 2003-12-01; WO2004AU01383 Applic. Date: 2004-10-11

Inventor: BROWN TRACEY J [AU]; BROWNLEE GARY R [AU]

Title: NANO IMPRINT MASTER AND METHOD OF MANUFACTURING THE SAME

Applicant/Assignee: SAMSUNG ELECTRONICS CO LTD [KR]

Application No.: 11/745609 Applic. Date: 2007-05-08

Abstract: A nano imprint master and a method of manufacturing the same are provided. The method includes: implanting conductive metal ions into a substrate including quartz to form a conductive layer inside the quartz substrate

coating a resist on the quartz substrate in which the conductive layer is formed, to form a resist coating layer

exposing the resist coating layer to an electron beam to form micropatterns

etching the quartz substrate by using the resist coating layer, in which the micropatterns are formed, as a mask

and removing the resist coating layer to obtain a master in which micropatterns are formed.

Priority: KR20060055538 Applic. Date: 2006-06-20; KR20060125657 Applic. Date: 2006-12-11

Inventor: KIM HAE-SUNG [KR]; KO HYOUNG-SOO [KR]; HONG SEUNG-BUM [KR]; SOHN JIN-SEUNG [KR]; CHOA SUNG-HOON [KR]; LIM CHEE-KHENG [KR]

Patent No.: US7462753B2 Issued: 2008-12-09

Title: Nano-silver wound dressing

Applicant/Assignee: CHUNG SHAN INSTITUTE OF SCIENCE AND TECHNOLOGY, ARMAMENTS BUREAU, M.N.D

Application No.: 11/455188 Applic. Date: 2006-06-19

Abstract: A nano-silver wound dressing consists of a skin contact layer made from hydrophilic cloth and directly contacting wound on surface of skin, a disinfecting (or bactericidal) antitoxic layer made from activated charcoal cloth impregnated with nanocrystalline silver, a blood absorbing and styptic layer made from non-woven cloth with superabsorbent polymer, an isolation layer made from composite fabric with pore size less than 5 mum, and an elastic bandage for fixing a main body on the site of wound. Edges of the isolation layer and the skin contact layer are integrated to form a main body while the disinfecting (or bactericidal) antitoxic layer as well as the blood absorbing and styptic layer are separated from each other and both enclosed inside the main body.

Inventor: MA RIN-HSIUNG [TW]; YU YI-HSIUAN [TW]

Title: DELIVERY OF AN AGENT USING IONTOPHORESIS

Applicant/Assignee: MINU L L C [US]

Application No.: 11/624400 Applic. Date: 2007-01-18

Abstract: A method and apparatus for delivering an agent to structures of the eye or other body sites using iontophoresis applied through the eyelid, skin, etc. of a patient. A drug is introduced into the eye or other body site. A first electrode is in electrical communication with the site and a second electrode is positioned in relation to the first electrode. The electrodes are energized to generate a current between the electrodes and through the site that facilitates the selective dissemination of the agent throughout the eye or site.

Priority: US2006-462499 Applic. Date: 2006-08-04; US20060805638P Applic. Date: 2006-06-23

Inventor: PEYMAN GHOLAM A [US]

Title: Multi-Component Dressing for Wound Treatment on the Human or Animal Body with Application of Reduced Pressure

Application No.: 11/666848 Applic. Date: 2005-11-02

Abstract: The invention relates to a multi-component dressing ( 100 ) for treating wounds of the human or animal body using a reduced pressure, having a wound-covering element ( 4 ) for mounting the dressing ( 100 ) at the surface of the skin and the mucous membrane and at least one connecting site ( 5 ), which is in contact with the wound space ( 10 ) and over which the materials in the wound space ( 10 ) can be evacuated. The multi-component dressing has super-absorbing polymers, the absorbed wound secretions remaining bound to polymers in the wound space until the latter are removed from the wound space and the polymers, due to their binding capacity, supporting reciprocal synergies with the sub-atmospheric pressures. Wound exudate, promoted by the reduced pressure, is also stored and controlled by polymerized granulates.

Priority: DE200420017052U Applic. Date: 2004-11-02; WO2005EP11701 Applic. Date: 2005-11-02

Inventor: RIESINGER BIRGIT [DE]

Title: Device for the Treatment of Wounds Using a Vacuum

Application No.: 11/666958 Applic. Date: 2005-11-02

Abstract: The invention relates to a device ( 100 ) for treating wounds of the human or animal body using a vacuum and having a gas-tight wound-covering element ( 4 ), which, when placed in contact with the body of the patient, forms a wound space ( 10 ) between the respective wound and the wound-covering element, at least one connecting site ( 5.1

5.2 ), which is in contact with the wound space ( 10 ), an absorption body ( 2 ), which is a layer, enclosed in an envelope, of a textile section, interspersed with super-absorbing particles, the envelope being permeable to liquids and having pores, the size of which does not exceed that of the super-absorbing particles. The absorption body ( 2 ), which is to be inserted in the wound space ( 10 ), has an initial volume, which enlarges in the course of the absorption process, and a final volume, so that, due to the size of the pores of the envelope, the absorbed wound secretions remain within the absorption body ( 2 ) and, with that, below the wound-covering element, until the absorption body is removed from the wound space.

Priority: DE200420017052U Applic. Date: 2004-11-02; WO2005EP11692 Applic. Date: 2005-11-02

Inventor: RIESINGER BIRGIT [DE]

Title: METAL-CONTAINING FORMULATIONS AND METHODS OF USE

Applicant/Assignee: NUCRYST PHARMACEUTICALS

Application No.: 11/766906 Applic. Date: 2007-06-22

Abstract: Metal-containing materials, as well as their preparation, formulations, and use are disclosed.

Priority: US20060818053P Applic. Date: 2006-06-30; US20060841940P Applic. Date: 2006-09-01

Inventor: LU CHENG Z [US]; CHEN WEN G [US]; BHOL KHAILASH [US]; LYCZAK JEFFREY B [US]; SCHECHTER PAUL [US]

Title: Nano-composite door facings, and related door assemblies and methods

Application No.: 11/878164 Applic. Date: 2007-07-20

Abstract: A door skin adapted for construction of a door assembly is provided. The door skin is embodied as a rectangular solid sheet having interior and exterior opposing surfaces. The solid sheet contains a polymeric material and a nanocomponent. Also provided are door assemblies, and related methods.

Priority: US20060832126P Applic. Date: 2006-07-21

Inventor: XU LIQUN [US]; PFAU JIM [US]

Title: Method of Producing Fibers by Electrospinning at High Pressures

Application No.: 10/596318 Applic. Date: 2004-12- 23

Abstract: A process of making fibers by electrostatic spinning includes the use of a mixing vessel ( 10 ), a piston ( 15 ) for pressurizing the polymer, carbon dioxide sources ( 20 ) for lowering the viscosity of the polymer or pressurizing the collection vessel ( 35 ), a pressure generator ( 25 ), view ports ( 30 ), a target ( 36 ), a spinning needle ( 40 ), a camera/TV recorder ( 45 ) and a voltage source ( 50 ).

Priority: US20030531675P Applic. Date: 2003-12-23; WO2004US43096 Applic. Date: 2004-12-23

Inventor: MCHUGH MARK [US]; SHEN ZHIHAO [US]; GEE DIANE [US]; KARLES GEORGIOS [US]; NEPOMUCENO JOSE [US]; HUVARD GARY [US]

Title: Novel Regimens for Treating Diseases and Disorders

Applicant/Assignee: BIOASSETS DEV CORP

Application No.: 11/775206 Applic. Date: 2007-07-09

Abstract: Methods and materials are provided for induction-maintenance regimens of targeted anti-inflammatory therapies (TATs) for treatment of a variety of diseases and disorders. Preferred embodiments include administration of one or more TATs using an induction regimen comprising a lower dose per administration administered by a more invasive and/or more localized route, followed by administration of one or more TATS using a maintenance regimen, comprising a higher dose per administration administered by a less invasive and/or less localized route.

Priority: US20060847493P Applic. Date: 2006-09-27; US20060819555P Applic. Date: 2006-07-07

Inventor: GORMAN JAMES R [US]

Title: Communication Unit for a Person's Skin

Application No.: 11/597730 Applic. Date: 2007-05-23

Abstract: Electric communication unit to be placed on a person's skin, comprising a support element ( 3 ), a series of body contacts ( 7 ), a pulse generator ( 6 ) provided for generating a series of pulses and for transmitting the series of pulses to said series of body contacts ( 7 ), said series of body contacts ( 7 ) being provided to transmit said series of pulses onto the skin of said person. The electric communication unit is in the form of a patch.

Priority: EP20040102382 Applic. Date: 2004-05-28; EP20040107002 Applic. Date: 2004-12-27; WO2005EP52411 Applic. Date: 2005-05-26

Inventor: DE GEEST JAN [BE]; DE GEEST WIM [BE]

Title: Stacked Layer Electrode For Organic Electronic Devices

Applicant/Assignee: UNIV CALIFORNIA [US]

Application No.: 11/664701 Applic. Date: 2005-10-24

Abstract: An electrode for an electro-optic device has a wetting layer of electrically conductive material formed on a substrate. A second layer of electrically conductive material is formed on the wetting layer of electrically conductive material. The wetting layer has a first wetting ability with respect to a surface of the substrate and the second layer has a second wetting ability with respect to the surface of said substrate. The first wetting ability is different from the second wetting ability and the wetting layer acts to alter an optical property of the electrode due to the wetting ability of the wetting layer on the surface of the substrate.

Priority: US20040621705P Applic. Date: 2004-10-25; WO2005US38137 Applic. Date: 2005-10-24

Inventor: YANG YANG [US]; WU HSING-EN E [US]

Title: METHOD OF MEDICAL TREATMENT USING CONTROLLED HEAT DELIVERY

Applicant/Assignee: MINU LLC [US]

Application No.: 11/562268 Applic. Date: 2006-11-21

Abstract: The present invention relates to a system for treating a patient. The system includes a device configured to be positioned adjacent a portion of the patient, a medicinal substance delivery device, adapted to delivery a medicinal substance to the portion of the patient, a heating means adapted to provide heat to the device and a control system configured to monitor the heating means and control the temperature of the device at the portion of the patient.

Priority: US2001-986141 Applic. Date: 2001-11-07; US2005-070659 Applic. Date: 2005-03-02; US2006-446065 Applic. Date: 2006-06-01; US2006-558788 Applic. Date: 2006-11-10

Inventor: PEYMAN GHOLAM A [US]

Title: Phototherapy Systems and Methods

Applicant/Assignee: LEDEEP LLC [US]

Application No.: 11/547865 Applic. Date: 2005-04-12

Abstract: A phototherapy method includes applying to skin a lotion which includes a carrier material and nanocrystals located in the carrier material, and exposing the lotion to photons of a first wavelength range such that the nanocrystals convert the photons of a first wavelength range into photons of a second wavelength range suitable for phototherapy and provide the photons of the second wavelength range to the skin.

Priority: US20040561797P Applic. Date: 2004-04-12; WO2005US12017 Applic. Date: 2005-04-12

Inventor: FISET PETER D [US]

Title: Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof

Applicant/Assignee: FOAMIX LTD [IL]

Application No.: 11/825406 Applic. Date: 2007-07-05

Abstract: The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester

a stabilizer selected from the group consisting of at least one surface-active agent

at least one polymeric agent and mixtures thereof

a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.

Priority: IL20020152486 Applic. Date: 2002-10-25; US2005-532618 Applic. Date: 2005-12-22; WO2003IB05527 Applic. Date: 2003-10-24; US2005-078902 Applic. Date: 2005-03- 11; US2007-717897 Applic. Date: 2007-03-13; US2007-653205 Applic. Date: 2007-01-12; US2004-835505 Applic. Date: 2004-04-28; US2004-911367 Applic. Date: 2004-08-04; US20060818634P Applic. Date: 2006-07- 05; US20020429546P Applic. Date: 2002-11-29; US20030492385P Applic. Date: 2003-08-04; US20030530015P Applic. Date: 2003-12-16

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; BERMAN TAL [IL]; ZIV ENBAL [IL]; SCHUZ DAVID [IL]

Title: METAL-CONTAINING FORMULATIONS AND METHODS OF USE

Applicant/Assignee: NUCRYST PHARMACEUTICALS

Application No.: 11/766902 Applic. Date: 2007-06-22

Abstract: Metal-containing materials, as well as their preparation, formulations, and use are disclosed.

Priority: US20060818053P Applic. Date: 2006-06-30; US20060841940P Applic. Date: 2006-09-01

Inventor: CHEN WEN G [US]; BHOL KHAILASH [US]; LYCZAK JEFFREY B [US]

Title: METHOD AND APPARATUS FOR MITIGATING TRAILING VORTEX WAKES OF LIFTING OR THRUST GENERATING BODIES

Application No.: 11/852753 Applic. Date: 2007-09-10

Abstract: This patent provides for a method and apparatus for mitigating the formation of concentrated wake vortex structures generated from lifting or thrust- generating bodies and maneuvering control surfaces wherein the use of contour surface geometries promotes vortex-mixing of high and low flow fluids. The method and apparatus can be combined with various drag reduction techniques, such as the use of riblets of various types and/or compliant surfaces (passive and active). Such combinations form unique structures for various fluid dynamic control applications to suppress transiently growing forms of boundary layer disturbances in a manner that significantly improves performance and has improved control dynamics.

Priority: US20060842987P Applic. Date: 2006-09-08

Inventor: SULLIVAN STEVEN [US]

Title: ENZYME INHIBITION USING NANOPARTICLES

Application No.: 11/554214 Applic. Date: 2006-10-30

Abstract: Methods and compositions useful for the inhibition of enzyme activity, including in the treatment of enzymatic dermatitis, are provided. Such compositions comprise a composite material comprising: (a) an exfoliated nanoparticle having a surface and (b) a metal selected from Groups 3 to 12, aluminum and magnesium, wherein the metal is loaded onto the surface of the nanoparticle.

Inventor: DI SALVO ANTHONY [US]; MORDAS CAROLYN J [US]; NIKOLOVSKI JANETA [US]; WIEGAND BENJAMIN C [US]

Title: COMPOSTION FOR SKIN EXTERNAL USE CONTAINING OMEGA-3 FATTY ACID

Applicant/Assignee: AMOREPACIFIC CORP [KR]

Application No.: 11/928669 Applic. Date: 2007-10-30

Abstract: Stable preparations containing omega-3 fatty acid as an effective ingredient are disclosed. Further, uses of omega-3 fatty acid in preventing or alleviating skin aging, moisturizing skin, improving skin roughness, restoring or strengthening skin barrier function, improving skin elasticity, recovering or preventing skin damage induced by UV are disclosed.

Priority: KR20060084425 Applic. Date: 2006-09-01; US2007-840512 Applic. Date: 2007-08-17

Inventor: CHO JUNCHEOL [KR]; KANG CHANKOO [KR]; HAN SANGHOON [KR]; SON EUI- DONG [KR]; KANG HAKHEE [KR]

Title: Aqueous fluid photoprotective compositions comprising ester-terminated poly(ester amide) polymers

Applicant/Assignee: OREAL [FR]

Application No.: 11/653868 Applic. Date: 2007-01-17

Abstract: Enhanced SPF and/or reduced fluffing fluid compositions for photoprotecting the skin and/or the hair against the damaging effects of ultraviolet radiation, contain: (a) at least one photoprotective system capable of screening out UV radiation

and (b) at least one ester-terminated poly(ester amide) (ETPEA) polymer, formulated into (c) a topically applicable, cosmetically acceptable aqueous support therefor

the subject aqueous compositions are advantageously vaporizable, especially in the form of sprays, confined within a pressurization device.

Priority: FR20060050192 Applic. Date: 2006-01-19; US20060762127P Applic. Date: 2006-01-26

Inventor: JOSSO MARTIN [FR]; CHEVALIER CYRIL [FR]; GAUDRY ANNE-LAURE [FR]

Title: Methods and systems for using molecular-film adhesives

Application No.: 11/519544 Applic. Date: 2006-09-11

Abstract: Various embodiments of the present invention are directed to molecular-film adhesives and methods and systems for using molecular-film adhesives. In one embodiment of the present invention, an amphipathic, biological-substrate-compatible adhesive is applied as a molecular-film. The amphipathic adhesive includes a first functional group, capable of bonding to a first substrate, and a second functional group, capable of bonding to a second, chemically dissimilar substrate.

Inventor: ZHANG SEAN X [US]; BECK PATRICIA A [US]

Title: Preparation of Chitin and Derivatives Thereof For Cosmetic and Therapeutic Use

Applicant/Assignee: MAVI SUD S R L [IT]

Application No.: 11/666427 Applic. Date: 2005-11-02

Abstract: The invention relates to novel chitin derivatives and their use in medical treatments of plastic surgery, dermocosmesis and therapy, in particular it relates to natural chitin derivatives, like chitin in nanofibrillar form, oxychitin and other chemical derivatives of chitin, chitosan-hyaluronate and associations for use as subcutaneous fillers or skin protectants.

Priority: IT2004RM00539 Applic. Date: 2004-11-02; WO2005IB53576 Applic. Date: 2005-11-02

Inventor: MUZZARELLI CORRADO [IT]; MORGANTI PIERFRANCESCO [IT]

Title: MOISTURE-MANAGEMENT IN HYDROPHILIC FIBERS

Application No.: 11/951736 Applic. Date: 2007-12-06

Abstract: Provided is a fabric having improved moisture-management performance and being resilient to repeated washing, as well as a process for manufacturing the fabric. The process, employing consecutive steps of hydrophilization and hydrophobization, includes defatting cotton or cellulose fibers and their coating with silicone nanoparticles.

Priority: IL20040165219 Applic. Date: 2004-11-15; US2005- 274052 Applic. Date: 2005-11-15

Inventor: BARAK YEHUDA [IL]; MOIS MONDER [IL]

Title: Extensible nonwoven webs containing multicomponent nanocomposite fibers

Applicant/Assignee: PROCTER & GAMBLE

Application No.: 11/606821 Applic. Date: 2006-11-30

Abstract: The present invention provides nonwoven webs comprising multicomponent nanocomposite fibers that enable the nonwoven webs to possess high extensibility. The multicomponent nanocomposite fibers comprise two or more components. Each component comprises a polymer composition and at least one component comprises a nanoparticles composition. The nonwoven webs comprising the multicomponent nanocomposite fibers have an average elongation at peak load which is greater than the average elongation at peak load of comparable nonwoven webs without nanocomposite fibers.

Inventor: COLLIAS DIMITRIS IOANNIS [US]; BROYLES NORMAN SCOTT [US]; BOND ERIC BRYAN [US]

Title: Extensible nonwoven webs containing monocomponent nanocomposite fibers

Applicant/Assignee: PROCTER & GAMBLE

Application No.: 11/606820 Applic. Date: 2006-11-30

Abstract: The present invention provides nonwoven webs comprising monocomponent nanocomposite fibers that enable the nonwoven webs to possess high extensibility. The monocomponent nanocomposite fibers comprise a polymer composition and a nanoparticles composition. The nonwoven webs comprising the monocomponent nanocomposite fibers have an average elongation at peak load which is greater than the average elongation at peak load of comparable nonwoven webs without nanocomposite fibers.

Inventor: COLLIAS DIMITRIS IOANNIS [US]; BROYLES NORMAN SCOTT [US]; BOND ERIC BRYAN [US]

Title: Virtual input device for computing

Application No.: 11/636228 Applic. Date: 2006-12-08

Abstract: A virtual input device or apparatus that replaces the typical mouse, keyboard or other finger manipulated inputs currently used as inputs for any type of computing system such as signals used to control computers, PDAs, Video Games, Multimedia Displays and other similar electronic systems whether of a desktop or mobile configuration.

Inventor: CONANT CARSON V [US]

Title: Foam prepared from nanoemulsions and uses

Applicant/Assignee: FOAMIX LTD [IL]

Application No.: 11/975621 Applic. Date: 2007-10-19

Abstract: The present invention provides a foamable composition for administration to the skin, body surface, body cavity or mucosal surface, e.g., the mucosa of the nose, mouth, eye, ear, respiratory system, vagina or rectum. The foamable oil in water nano emulsion composition includes: (a) a nano oil globule system, comprising substantially of sub-micron oil globules

(b) about 0.1% to about 5% by weight of at least one stabilizing agent, selected from the group consisting of (i) a non-ionic surfactant, (ii) an ionic surfactant, and (iii) a polymeric agent

and (c) a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition, water and optional ingredients are added to complete the total mass to 100%. Upon release from an aerosol container, the foamable composition forms and expanded foam suitable for topical administration. The present invention further provides methods of treating, alleviating or preventing a disorder of the skin, body cavity or mucosal surface using such foamable compositions

and to methods of producing such foams having an improved bubble size.

Priority: IL20020152486 Applic. Date: 2002-10-25; US2006-389742 Applic. Date: 2006-03-27; US2004-911367 Applic. Date: 2004-08-04; US2005-532618 Applic. Date: 2005-12- 22; WO2003IB05527 Applic. Date: 2003-10-24; US20030492385P Applic. Date: 2003-08-04; US20050717058P Applic. Date: 2005-09-14; US20020429546P Applic. Date: 2002-11-29

Inventor: TAMARKIN DOV [IL]; BESONOV ALEX [IL]; EINI MEIR [IL]; DANZIGER JORGE [IL]

Title: Methods, treatments, and compositions for modulating Hedgehog pathways

Application No.: 12/001869 Applic. Date: 2007-12-13

Abstract: The present invention relates to prevention of congenital deformations The invention further relates to cancer inhibition and prevention. The invention further relates to methods and compositions to modulate, antagonize, or agonize disparate signaling pathways that may converge to regulate patterning events gene expression during prenatal development, post-natal development and during development in the adult organism.

Priority: US2006-591398 Applic. Date: 2006-11-01

Inventor: JENNINGS -SPRING BARBARA L [US]

Title: USE OF NANOPARTICLES IN THE PHOTODYNAMIC TREATMENT OF TUMORS AND NON-DESTRUCTIVE TESTING

Applicant/Assignee: UNIV HOUSTON SYSTEM [US]

Application No.: 11/856505 Applic. Date: 2007-09-17

Abstract: A method for generating light intensity inside a tumor to aid in the treatment of diseases such as cancer is disclosed. The light is generated inside the body to perform a modified photodynamic therapy treatment (PDT) that allows treatment of body regions that are inaccessible by normal PDT procedures. In addition, the use of two spatially and temporally coincident treatment modalities, i.e. radiation and PDT, have the potential for significant biological synergy in the tumor.

Priority: US20060845400P Applic. Date: 2006-09-18

Inventor: BENSAOULA ABDELHAK [US]; BONEY JOHN CHRISTOPHER [US]; BEDDAR A SAM [US]; BRIERE TINA MARIE [US]; KRISHNAN SUNIL [US]; LEE ANDREW K [US]

Title: METHODS AND SYSTEMS FOR MONITORING STRUCTURES AND SYSTEMS

Application No.: 11/693878 Applic. Date: 2007-03-30

Abstract: Methods and systems for passenger monitoring and system control is provided. The system includes at least one sensor system configured to monitor an environment immediately surrounding the respective passenger and biometrics of the respective passenger and generate sensor data indicative of a state of the passenger. The system also includes a processing system configured to receive the sensor data. The processing system includes an ontology and reasoning module configured to model at least one of the plurality of passengers, reason about the received sensor data associated with the at least one of the plurality of passengers. The processing system also includes a contextual analyzer configured to transmit the received sensor data to said ontology and reasoning module and to store the information into a contextual information database.

Priority: US2007-620871 Applic. Date: 2007-01-08

Inventor: GEORGESON GARY E [US]

Title: Colored or colorable foamable composition and foam

Application No.: 11/900328 Applic. Date: 2007-09-10

Abstract: There is described a colored or colorable topical composition, comprising: a) a foamable base composition comprising, 1) a flowable carrier composition

2) a color agent

wherein the color agent is effective to impart, increase, decrease or otherwise affect color of a foam produced from the foamable composition and wherein the color agent is one or more agents selected from the group consisting of a colored active agent, a colored indicator, a colored excipient, a pigment, a dye, a colorant and a coloring agent

b) a propellant at a concentration of about 3% to about 25% by weight of the total composition

wherein the base composition has a first color

and wherein the foam comprising the colored or colorable topical composition has a second color upon dispensing from an aerosol container, and wherein the first color and the second color are visually different. There is also described a method of changing color, a method of administration, a use as a diagnostic and a kit.

Priority: US20060843144P Applic. Date: 2006-09-08

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; EINI MEIR [IL]

Title: AMPHIPHILIC BLOCK COPOLYMERS AND NANOPARTICLES COMPRISING THE SAME

Applicant/Assignee: IND TECH RES INST

Application No.: 12/053327 Applic. Date: 2008-03-21

Abstract: An amphiphilic block copolymer is disclosed. The amphiphilic block copolymer includes one or more hydrophilic polymers, one or more hydrophobic polymer, and one or more zwitterions. The invention also provides a nanoparticle and carrier including the amphiphilic block copolymer for delivery of water insoluble drugs, growth factors, genes, or water insoluble cosmetic substances.

Priority: US2005-268544 Applic. Date: 2005-11-08

Inventor: HSIEH MING-FA [TW]; CHANG HSUEN-TSENG [TW]; CHEN CHIN-FU [TW]

Title: SHIUNKO NANOMICELL FOR SKIN TREATMENT AND PREPARATION METHOD FOR THE SAME

Applicant/Assignee: KAOHSIUNG MEDICAL UNIVERSITY [TW]

Application No.: 11/845171 Applic. Date: 2007-08-27

Abstract: The present invention provides a nanomicell for a skin, and the nanomicell includes an oil substance, an extract of a Angelica Radix, an extract of a Lithospermum Radix, and a phospholipid layer. The extract of a Angelica Radix is formed by extracting the Angelica Radix with the oil substance, and the extract of a Lithospermum Radix is formed by extracting the Lithospermum Radix with the oil substance. The extract of the Angelica Radix and the extract of the Lithospermum Radix are packaged within the phospholipid layer to form a plurality of micells having a diameter of nano-level.

Priority: TW20070103618 Applic. Date: 2007-01-31

Inventor: CHANG CHIH-HAO [TW]; TSAI TONG-RONG [TW]; HU WEN-LUNG [TW]

Title: Compositions and methods for treating or preventing skin inflammation via restoration of skin barrier function

Application No.: 11/985806 Applic. Date: 2007- 11-16

Abstract: Compositions, kits and methods are provided for restoring skin barrier function to skin of a subject after a medical or a cosmetic procedure. In general, a composition containing divalent cations such as calcium ions and/or magnesium ions in a physiologically acceptable medium can be used to treat, inhibit or prevent inflammation of skin post medical, demertological, or cosmetic procedure such as chemical peeling, laser skin resurfacing, microdermabrasion, plasma energy treatment, radiofrequency treatment, hair or vein removal or lightening, skin treatment using light energy or photofacial, thereby treating, inhibiting or preventing post-inflammatory hyperpigmentation of the skin or other skin disorders.

Priority: US2006-275994 Applic. Date: 2006-02-08; US20050652196P Applic. Date: 2005-02-11

Inventor: TANOJO HANAFI [US]; HUANG XINFAN [US]

Title: Pyrimidine Derivatives

Application No.: 11/661041 Applic. Date: 2005-08-29

Abstract: The present invention relates to pyrimidine derivatives, methods for their synthesis, and the use of said pyrimidine derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of cell proliferation disorders, cancer, leukemia, erectile dysfunction, cardiovascular diseases and disorders, inflammatory diseases, transplant rejection, immunological diseases, neuroimmunological diseases, autoimmune diseases, infective diseases including opportunistic infections, prion diseases and/or neuro- degeneration. Furthermore, the present invention relates to pharmaceutical compositions containing at least one pyrimidine derivative and/or pharmaceutically acceptable salts thereof as an active ingredient together with at least one pharmaceutically acceptable carrier, excipient or diluents as well as to methods for prophylaxis and/or treatment of the above-mentioned diseases and disorders.

Priority: US20040604685P Applic. Date: 2004-08-27; WO2005EP09291 Applic. Date: 2005-08-29

Inventor: KLEBL BERT [DE]; BAUMANN MATTHIAS [DE]; HOPPE EDMUND [DE]; BREHMER DIRK [DE]; DAUB HENRIK [DE]; KERI GYORGY [HU]; VARGA ZOLTAN [HU]; MAROSFALVI JENO [HU]; ORFI LASZLO [HU]

Title: Use of high dose concentrations of gaseous nitric oxide

Application No.: 11/704602 Applic. Date: 2007-02-09

Abstract: The invention relates to a methods and devices of delivering gaseous nitric oxide to a mammal or surface at a concentration ranging from about 1000 ppm to about 50,000 ppm of gaseous nitric oxide. Different conditions which can be treated by high dosage administration of gNO include but are not limited to: topical treatments with gNO, cosmetic applications of gNO, vasodilation conditions with gNO, inhalation treatments with gNO, treatments of the blood with gNO, treatment of the skin or tissue with gNO, treatment of infections with gNO, treatment of inflammation on or within the body, and treatments of biofilms with gNO. Other conditions, aliments, or symptoms that may be treated with high dosage gNO include bronchoconstriction, reversible pulmonary vasoconstriction, asthma, pulmonary hypertension, adult respiratory distress syndrome (ARDS), and persistent pulmonary hypertension of the newborn (PPHN).

Inventor: MILLER CHRISTOPHER C [CA]; HOLE DOUGLAS R [CA]; LEE ROBERT E [CA]

Title: Absorbent Article With Barrier Sheet

Applicant/Assignee: PROCTER & GAMBLE [US]

Application No.: 12/030610 Applic. Date: 2008-02-13

Abstract: The present invention is directed to an absorbent article having a backsheet, an absorbent core and cuffs and/or a topsheet, the topsheet being provided with at least one opening adapted to receive fecal material, the cuffs or topsheet comprising a nonwoven sheet material, comprising typically at least two nonwoven layers, the layers being typically only partially attached to one another and each comprising typically two or more nonwoven webs that are laminated together, whereof the skin-contacting nonwoven layer or web has a specific low bending rigidity, whilst the nonwoven sheet as a whole has a very high barrier function.

Priority: EP20070102195 Applic. Date: 2007-02-13; EP20070102196 Applic. Date: 2007-02-13; EP20070123747 Applic. Date: 2007-12-20

Inventor: PONOMARENKO EKATERINA ANATOLYE [DE]; WISE BRANDON ELLIS [US]

Title: CONTINUOUS CONDUCTIVE MATERIALS FOR ELECTROMAGNETIC SHIELDING

Application No.: 11/674995 Applic. Date: 2007-02-14

Abstract: A medical electrical lead having a conductor assembly covered by an insulating layer, and a shield covering positioned adjacent or proximate to at least a portion of the insulating layer in order to shield the conductor assembly from one or more electromagnetic fields. The shield covering is formed of a material that is electrically conductive, where the material is in a wrapped or woven form. The material is selected so as to have an effective combination of small size and high conductive surface area, e.g., as opposed to metal wire or coatings thinner than metal wire. As such, the shield covering exhibits sufficient conductivity in the presence of one or more high frequency electromagnetic fields so that interference to the operation of the conductor assembly is minimized. The material can have a coating formed of one or more metals. The material can include carbon. In turn, the carbon can be formed of one or more of carbon fiber, carbon nanofiber, and single or multi-walled carbon nanotube.

Inventor: LI BERNARD [US]; CAI CHAD [US]; CHEN XINGFU [US]

Title: DISCONTINUOUS CONDUCTIVE FILLER POLYMER-MATRIX COMPOSITES FOR ELECTROMAGNETIC SHIELDING

Application No.: 11/674992 Applic. Date: 2007-02-14

Abstract: A medical electrical lead having a conductor assembly covered by an insulating layer, and a shield covering positioned adjacent or proximate to at least a portion of the insulating layer in order to shield the conductor assembly from one or more electromagnetic fields. The shield covering is formed of a polymer-matrix composite. The polymer-matrix composite includes a polymeric resin having discontinuous conductive fillers provided therein. The discontinuous conductive fillers include one or more of nano-sized metal structures and nano-sized non-metallic conductive structures. The nano-sized non-metallic conductive structures can have a coating formed of one or more metals. The nano-sized non-metallic conductive structures can be formed of carbon. In turn, the nano- sized non-metallic conductive structures can include one or more of carbon nanofibers, carbon filaments, carbon nanotubes, and carbon nanoflakes.

Inventor: LI BERNARD [US]; CAI CHAD [US]; CHEN XINGFU [US]

Title: Spray Dried Compositions

Application No.: 11/883215 Applic. Date: 2005-12-20

Abstract: The invention provides a method comprising the steps of: (i) providing an emulsion of: a) an aqueous solvent, such as water, b) a carrier material dispersible or soluble in (a), said carrier material being solid at ambient temperature, and preferably being a polymer and inorganic salt or a surfactant, c) a volatile second liquid phase (for example, chloroform) which is not miscible with (a), and d) a material which is dispersible or soluble in (c) but not in (a), and, (ii) Drying the emulsion at above ambient temperature (preferably by spray drying) to simultaneously remove (a) and (c) and thereby obtain the material (b) in solid form with (d) dispersed therein.

Priority: GB20050001835 Applic. Date: 2005-01-28; WO2005EP13933 Applic. Date: 2005-12-20

Inventor: BARNWELL STEPHEN GEORGE [GB]; COOPER ADREW IAN [GB]; DUNCALF DAVID JOHN [GB]; FOSTER ALISON JAYNE [GB]; RANNARD STEVEN PAUL [GB]

Title: DEVICE AND METHOD FOR INCREASING BLOOD FLOW AND INSULIN-LIKE GROWTH FACTOR

Application No.: 12/035457 Applic. Date: 2008-02-22

Abstract: In order to provide a device and a method for increasing blood flow and an insulin-like growth factor with use of a large amount of carbonic gas nano bubbles, the device of the present invention includes: a bathtub 1

and a nano bubble-producing section 41 for producing carbonic gas nano bubbles in bath water in the bathtub 1.

Priority: JP20070050639 Applic. Date: 2007-02-28

Inventor: YAMASAKI KAZUYUKI [JP]; MIYAMOTO TAKAHIDE [JP]; CHUHJOH KAZUMI [JP]; KATAOKA MASAKI [JP]

Title: ANIONIC LATEX AS A CARRIER FOR ACTIVE INGREDIENTS AND METHODS FOR MAKING AND USING THE SAME

Application No.: 12/116040 Applic. Date: 2008-05-06

Abstract: This invention relates to the field of polymeric materials that can be used in combination with a wide variety of substrates, such as personal care products, textiles, metal, cellulosic materials, plastics, and the like, and to the field of active agents including, for example, antimicrobial, antibacterial and antifungal materials. This invention further relates to latex polymer coatings that comprise at least one active component as well as methods for making and using such latex compositions.

Priority: US2007-895539 Applic. Date: 2007-08-24; US20060839892P Applic. Date: 2006-08-24

Inventor: KRISHNAN VENKATARAM [US]

Title: WAVEGUIDE STRUCTURE, MANUFACTURING METHOD THEREOF AND HAMR USING THE SAME

Applicant/Assignee: SAMSUNG ELECTRONICS CO LTD [KR]

Application No.: 11/972207 Applic. Date: 2008-01-10

Abstract: A manufacturing method of a waveguide structure includes forming a metal layer of a predetermined size on a substrate to form a structure, forming a lower clad layer on the structure in order to completely cover the metal layer, forming a core layer of a predetermined size on the lower clad layer at the location corresponding to the metal layer, and forming an upper clad layer thereon in order to completely cover the core layer.

Priority: KR20070003058 Applic. Date: 2007-01-10

Inventor: SUH SUNG-DONG [KR]; CHO EUN-HYOUNG [KR]; SOHN JIN SEUNG [KR]

Title: Differentially Expressed Nucleic Acids in the Blood- Brain Barrier Under Inflammatory Conditions

Application No.: 10/544991 Applic. Date: 2004-02-10

Abstract: The present invention relates to nucleic acids and polypeptides encoded thereby, whose expression is modulated in brain microvascular endothelial cells undergoing early dynamic inflammation-induced changes in blood-brain barrier functionality. Such polypeptides are referred to as lipopolysaccharide-sensitive (LPSS) polypeptides herein. These nucleic acids and polypeptides may be useful in methods for controlling blood-brain barrier properties in mammals in need of such biological effects. This includes the diagnosis and treatment of disturbances in the blood- brain/retina barrier, brain (including the eye) disorders, as well as peripheral vascular disorders. Additionally, the invention relates to the use of anti-LPSS polypeptide antibodies or ligands as diagnostic probes, as blood-brain barrier targeting agents or as therapeutic agents as well as the use of ligands or modulators of expression, activation or bioactivity of LPSS polypeptides as diagnostic probes, therapeutic agents or drug delivery enhancers.

Priority: EP20030075390 Applic. Date: 2003-02-10; US20030446270P Applic. Date: 2003-02-11; US20030491522P Applic. Date: 2003-08-01; WO2004NL00092 Applic. Date: 2004-02-10

Inventor: GAILLARD PIETER JAAP [NL]; DE BOER ALBERTUS GERRIT [NL]; BRINK ARJEN [NL]

Title: Cosmetic or Dermopharmaceutical Composition Comprising at Least one Udp Glucuronosyl Transferase (Ugt) Enzymes Inducer

Applicant/Assignee: SEDERMA SAS [FR]

Application No.: 11/587533 Applic. Date: 2005-04-25

Abstract: The invention relates to topical use of at least one UGT inducer for the preparation of a cosmetic or dermopharmaceutical composition comprising a dermatologically acceptable carrier to protect and/or enhance the state of the skin and prevent and/or treat imperfections of the skin.

Priority: FR20040004408 Applic. Date: 2004-04-26; WO2005IB51344 Applic. Date: 2005-04-25

Inventor: LINTNER KARL [FR]; MAS CHAMBERLIN CLAIRE [FR]

Title: Surface- Enhanced Spectroscopy with Implanted Biosensors

Applicant/Assignee: KONINKL PHILIPS ELECTRONICS NV [NL]

Application No.: 11/816534 Applic. Date: 2006-02-16

Abstract: The present invention provides a spectroscopic apparatus, a method and a computer program product for determining the concentration of an analyte of a fluid that flows through a capillary vessel of a biological sample. The spectroscopic apparatus makes use of an imaging system for determining the position of at least one biosensing substrate that has been implanted into the biological sample in the proximity of the capillary vessel but outside the capillary vessel. The biosensing substrate is capable of inducing surface-enhanced spectroscopic effects and is preferably adapted to reversibly and selectively bind a certain analyte or molecule of the fluid, to which the vessel wall of the capillary vessel is at least semi-permeable. By performing a spectroscopic analysis not directly inside the capillary vessel but in close proximity to the capillary vessel, the signal-to- noise ratio of the spectroscopic signals obtained can be appreciably enhanced while disadvantageous scattering and interference effects can be minimized.

Priority: EP20050101329 Applic. Date: 2005-02-22; WO2006IB50510 Applic. Date: 2006-02-16

Inventor: VAN GOGH ANTONIUS THEODORUS MARTINUS [NL]; T HOOFT GERT [NL]; LUCASSEN GERHARDUS WILHELMUS [NL]

Title: Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances

Applicant/Assignee: NANOMED DEVICES INC [US]

Application No.: 11/961816 Applic. Date: 2007-12-20

Abstract: A system and method of using a high- aspect ratio microdevice for treating, preventing or ameliorating a medical condition is provided.

Priority: US20060876948P Applic. Date: 2006-12-22

Inventor: XU BAI [US]

Title: Mesoporous material compositions and methods of their use for improving the appearance of biological surfaces

Application No.: 11/714516 Applic. Date: 2007-03-06

Abstract: The present invention relates to compositions and methods for treating and improving the aesthetic appearance of a biological surface by altering the optical properties of the biological surface, thereby resulting in a natural appearance. The compositions of the invention may be topically applied to the biological surface, including but not limited to skin, in an amount effective in improving the aesthetic and natural appearance of the biological surface.

Inventor: MAITRA PRITHWIRAJ [US]; BRAHMS JOHN C [US]

Title: METHOD AND PROCESS FOR THE PRODUCTION OF MULTI-COATED RECOGNITIVE AND RELEASING SYSTEMS

Applicant/Assignee: UNIV TEXAS [US]

Application No.: 12/047309 Applic. Date: 2008-03-12

Abstract: The present invention includes compositions, methods, systems and kits for the controlled delivery of an active agent within a polymeric network upon the binding of a molecule that decreases the structural integrity of the polymeric network at one or more micro- or nanovacuoles.

Priority: US20070894451P Applic. Date: 2007-03-12

Inventor: PEPPAS NICHOLAS A [US]

Title: BATHTUB APPARATUS, THERAPEUTIC BATHTUB APPARATUS, BATHING WATER AND THERAPEUTIC BATHING WATER

Application No.: 12/056435 Applic. Date: 2008-03-27

Abstract: A bathtub apparatus is provided, including a nanobubble and/or nanosized medical component generating section to combine at least either of nanobubbles or a nanosized medical component with bath water from a bathtub and to circulate the bath water to the bathtub.

Priority: JP20070093215 Applic. Date: 2007-03-30

Inventor: YAMASAKI KAZUYUKI [JP]; MIYAMOTO TAKAHIDE [JP]; CHUHJOH KAZUMI [JP]; KATAOKA MASAKI [JP]

Title: Isolation and Cultivation of Stem/Progenitor Cells From the Amniotic Membrane of Umbilical Cord and Uses of Cells Differentiated Therefrom

Applicant/Assignee: CELLRES CORP PTE LTD [SG]

Application No.: 12/091018 Applic. Date: 2006-10-11

Abstract: The present invention relates to a skin equivalent and a method for producing the same, wherein the skin equivalent comprises a scaffold and stem/progenitor cells isolated from the amniotic membrane of umbilical cord. These stem/progenitor cells may be mesenchymal (UCMC) and/or epithelial (UCEC) stem cells, which may then be further differentiated to fibroblast and keratinocytes. Further described is a method for isolating stem/progenitor cells from the amniotic membrane of umbilical cord, wherein the method comprises separating the amniotic membrane from the other components of the umbilical cord in vitro, culturing the amniotic membrane tissue under conditions allowing cell proliferation, and isolating the stem/progenitor cells from the tissue cultures. The invention also refers to therapeutic uses of these skin equivalents. Another aspect of the invention relates to the generation of a mucin-producing cell using stem/progenitor cells obtained from the amniotic membrane of umbilical cord and therapeutic uses of such mucin-producing cells. In yet another aspect, the invention relates to a method for generating an insulin-producing cell using stem/progenitor cells isolated from the amniotic membrane of umbilical cord and therapeutic uses thereof. The invention further refers to a method of treating a bone or cartilage disorder using UCMC. Furthermore, the invention refers to a method of generating a dopamin and tyrosin hydroxylase as well as a HLA-G and hepatocytes using UCMC and/or UCEC. The present invention also refers to a method of inducing proliferation of aged keratinocytes using UCMC.

Priority: US20050729172P Applic. Date: 2005-10-21; WO2006SG00301 Applic. Date: 2006-10-11

Inventor: PHAN TOAN-THANG [SG]

Title: BONE TREATMENT SYSTEMS AND METHODS

Application No.: 12/062345 Applic. Date: 2008-04-03

Abstract: Systems and methods for delivering bone cement into a bone can include a handle body defining a flow path, a thermal emitter in the handle body to apply energy to bone cement passing through the flow path, a source of bone cement and an injection cannula. The cannula can be in communication with the flow path such that inserting the cannula into a bone can allow a flow of bone cement therethrough to an opening at a distal end of the cannula. Other systems and methods for delivering bone cement into a bone can include an injector body with a handle portion, and a cannula, a bone cement container, a low pressure drive mechanism configured to effect a flow of bone cement from said container to the injector body and a high pressure drive mechanism configured to effect a flow of bone cement through the injector body into the bone.

Priority: US20070907467P Applic. Date: 2007-04-03; US20070907468P Applic. Date: 2007-04-03; US20070907469P Applic. Date: 2007-04-03; US20070929416P Applic. Date: 2007-06-26

Inventor: TRUCKAI CSABA [US]; LUZZI ROBERT [US]; SHADDUCK JOHN H [US]

Title: PERMEATION ENHANCING COMPOSITIONS FOR ANTICHOLINERGIC AGENTS

Application No.: 12/147816 Applic. Date: 2008-06-27

Abstract: A transdermal or topical skin -friendly composition including anticholinergic agents, such as oxybutynin, a urea-containing compound and a carrier system. A method is disclosed for treating a subject for urinary incontinence while reducing the incidences of peak concentrations of drug and undesirable side effects associated with oral anticholinergics.

Priority: US2005-120306 Applic. Date: 2005-05-02; US20040568983P Applic. Date: 2004-05-07

Inventor: GRENIER ARNAUD [FR]; CARRARA DARIO NORBERTO R [CH]; DECAUDIN CELINE [FR]

Title: Cationic Polymer Nanoparticles Encapsulating An Active Ingredients, And The Cosmetic Composition Containing The Same

Applicant/Assignee: AMOREPACIFIC CORP [KR]

Application No.: 12/090680 Applic. Date: 2006-10-18

Abstract: Disclosed herein are cationic polymer nanocapsules encapsulating an oil-soluble active ingredient, and a cosmetic composition containing the same. The cationic polymer nanocapsules have a molecular weight of 5,000-100,000, a surface potential of 5-100 mV and a particle size of 50-500 nm. Also, disclosed is a cosmetic composition containing said cationic polymer nanocapsules.

Priority: KR20050098057 Applic. Date: 2005-10-18; KR20060101316 Applic. Date: 2006-10-18; WO2006KR04238 Applic. Date: 2006-10-18

Inventor: KIM YONG JIN [KR]; KIM JIN WOONG [KR]; RYU JU HEE [KR]; SHIM JONG WON [KR]; KIM JUN OH [KR]; CHANG IH SEOP [KR]

Title: METHOD AND COMPOSITION FOR TREATING CANCER

Application No.: 12/044761 Applic. Date: 2008-03-07

Abstract: A method for treating cancer, preventing cancer or delaying the progression of a cancer in an animal or a human comprising the step of: administering to the animal or the human having a cancer a composition in an amount effective to treat cancer, prevent cancer or delay the progression of cancer in the animal or the human. The composition comprises a pharmaceutically acceptable excipient, and ascorbate which is joined to a carrier structure containing an anti-cancer active agent, said carrier structure being capable of releasing the anti-cancer agent in the presence of a reactive oxygen species.

Priority: US20070905902P Applic. Date: 2007-03-09

Inventor: MANGANARO ANTHONY [US]; ROCKWELL KAREN [US]

Title: Composition comprising encapsulated silicone compounds

Applicant/Assignee: OREAL [FR]

Application No.: 12/003026 Applic. Date: 2007-12-19

Abstract: The present invention relates to a cosmetic composition intended for the care and/or make-up of keratinous substance(s) comprising, in a physiologically acceptable medium, at least one compound X, one compound Y and at least one catalyst, with at least one of the compounds X or Y being a polyorganosiloxane, and said compounds X and Y being capable of reacting together by a hydrosilylation reaction in the presence of a catalyst, with at least one compound from the compounds X and Y being present in said composition in an encapsulated form, said catalyst being combined with at least one of said encapsulated compound X or Y.

Priority: FR20060055681 Applic. Date: 2006-12-20; US20070883175P Applic. Date: 2007- 01-03

Inventor: PRIGENT FANNY [FR]; SIMMONET JEAN-THIERRY [FR]

Title: Use of Dha, Epa or Dha-Derived Epa for Treating a Pathology Associated with Cellular Oxidative Damage

Applicant/Assignee: BRUDY TECHNOLOGY S L [ES]

Application No.: 12/158205 Applic. Date: 2006-12-20

Abstract: The present invention relates to the use of an acid enriched in docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA) or DHA-derived EPA for manufacturing a drug for the treatment of processes that involve associated oxidative damage. In particular, it is for the treatment of processes associated with neurodegenerative, ocular, ischaemic and inflammatory pathology, atherosclerosis, with oxidative damage to DNA and with physical exercise.

Priority: ES20050003202 Applic. Date: 2005-12-21; ES20060002417 Applic. Date: 2006-09-25; ES20060002418 Applic. Date: 2006-09-25; ES20060003231 Applic. Date: 2006-12-20; WO2006EP70016 Applic. Date: 2006-12-20

Inventor: DOMINGO PEDROL JOAN CARLES [ES]; VILLEGAS GARCIA JOSE ANTONIO [ES]

Title: Antitumoral Bioconjugates of Hyaluronic Acid or Its Derivatives Obtained by Indirect Chemical Conjugation, and Their Use in the Pharmaceutical Field

Application No.: 11/989716 Applic. Date: 2006-08-02

Abstract: The present invention describes a new group of bioconjugates which can be obtained by means of indirect synthesis, via a molecular spacer, between hyaluronic acid and/or its derivatives and drugs with an antitumoral activity belonging to different groups, their preparation process and use in the oncological field. The new derivatives, in relation to the type of bond and Substitution degree, have different physico-chemical properties which improve their tolerability and efficiency and allow a more accurate modulation of the dosage, exploiting an active targeting mechanism.

Priority: IT2005PD00242 Applic. Date: 2005-08-03; WO2006EP07717 Applic. Date: 2006-08-02

Inventor: RENIER DAVIDE [IT]; BETTELLA FABIO [IT]

Title: Methods of Inducing Melanogenesis in a Subject

Applicant/Assignee: CLINUVEL PHARMACEUTICALS LTD [AU]

Application No.: 11/659178 Applic. Date: 2005-02-11

Abstract: Described herein are methods and compositions for inducing melanogenesis in a human subject. The method comprises administering to a subject an alpha-MSH analogue, in an effective amount and time to induce melanogenesis by the melanocytes in epidermal tissue of subject without inducing homologous desensitization of the melanocortin-1 receptors.

Priority: US20040599143P Applic. Date: 2004-08-04; WO2005AU00181 Applic. Date: 2005-02-11

Inventor: KLEINIG MICHAEL JOHN [AU]; TICE THOMAS R [US]; STAAS JAY K [US]

Title: Cosmetic compositions

Application No.: 11/809947 Applic. Date: 2007-06-05

Abstract: A cosmetic composition suitable for topical application to human or animal skin comprising an effective amount of active ingredient dispersed in an acceptable cosmetic base or carrier, wherein the active ingredient comprises a mixture of an amino acid, a low glycemic glycoside and a Vitamin, wherein the amino acid is L-arginine, and wherein the low glycemic glycoside is derived from kiwi fruit.

Inventor: DUPREY JR JAMES R [US]

Title: Serum Albumin Conjugated to Fluorescent Substances for Imaging

Applicant/Assignee: BETH ISRAEL HOSPITAL [US]

Application No.: 10/579613 Applic. Date: 2004-11-17

Abstract: Compositions and methods are disclosed for imaging tissue or a lymphatic or circulatory system, for example, in the near infrared. Dyes that emit wavelengths in the infrared or near infrared regions of the spectrum may be employed on their own, as combinations or complexed with serum albumin, or as part of a covalent conjugate with serum albumin.

Priority: US20030523059P Applic. Date: 2003-11-18; US20040608267P Applic. Date: 2004-09-09; WO2004US38682 Applic. Date: 2004-11-17

Inventor: FRANGIONI JOHN V [US]; ONISHI SHUNSUKE [JP]

Title: Cosmetic Treatment With Nitric Oxide, Device For Performing Said Treatment And Manufacturing Method Therefor

Application No.: 11/909152 Applic. Date: 2006-02-13

Abstract: A cosmetic treatment method, and a device therefor, are provided that allow for cosmetic treatment of cosmetic disorders, caused by chronological age, environmental factors, changes in physiological functions of skin, such as psoriasis, dermatitis, acne, cellulites, and viral and/or bacteriological attacks. The device comprises a nitric oxide (NO) eluting polymer arranged to contact the area to be cosmetically treated, such that a cosmetic dose of nitric oxide is eluted from said nitric oxide eluting polymer to said area. The nitric oxide (NO) eluting polymer is integrated with a carrier material, such that said carrier material, in use, regulates and controls the elution of said cosmetic dosage of nitric oxide (NO). Furthermore, a manufacturing method for said device is provided.

Priority: EP20050006474 Applic. Date: 2005-03-24; EP20050018269 Applic. Date: 2005-08-23; US20050666504P Applic. Date: 2005-03-30; US20050711006P Applic. Date: 2005-08-24; WO2006EP50884 Applic. Date: 2006-02-13

Inventor: PETERS TOR [SE]

Title: FOAMABLE COMPOSITIONS AND KITS COMPRISING ONE OR MORE OF A CHANNEL AGENT, A CHOLINERGIC AGENT, A NITRIC OXIDE DONOR, AND RELATED AGENTS AND THEIR USES

Applicant/Assignee: FOAMIX LTD [IL]

Application No.: 11/767442 Applic. Date: 2007-06-22

Abstract: The present invention relates to a foamable therapeutic composition comprising: (a) a therapeutically effective concentration of at least one active agent selected from the group consisting of a channel agent, a cholinergic agent, and a nitric oxide donor

and (b) a foamable carrier comprising: i. about 50% to about 98% of a solvent selected from the group consisting of water

a hydrophilic solvent

a hydrophobic solvent

a potent solvent

a polar solvent, a silicone, an emollient, and mixtures thereof

ii. 0% to about 48% of a secondary solvent selected from the group consisting of water

a hydrophilic solvent

a hydrophobic solvent

a potent solvent

a polar solvent, a silicone, an emollient, a co-solvent, a penetration enhancer and mixtures thereof

iii. a surface-active agent

iv. about 0% to about 5% by weight of at least one polymeric agent

and v. a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition

wherein the composition is housed in a container and is substantially flowable, and which upon release expands to form a breakable foam

and wherein the foamable carrier is selected to generate a foam of good to excellent quality. The invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering such a composition to an afflicted target site.

Priority: IL20020152486 Applic. Date: 2002-10-25; US2004-911367 Applic. Date: 2004-08-04; US2005-532618 Applic. Date: 2005-12-22; WO2003IB05527 Applic. Date: 2003-10-24; US2004-835505 Applic. Date: 2004-04-28; US2006-430437 Applic. Date: 2006-05-09; US2006-430599 Applic. Date: 2006-05-09; US20030492385P Applic. Date: 2003-08-04; US20020429546P Applic. Date: 2002-11-29; US20050679020P Applic. Date: 2005-05-09; US20060784793P Applic. Date: 2006-03-21; US20030530015P Applic. Date: 2003-12-16; US20060815948P Applic. Date: 2006-06-23

Inventor: TAMARKIN DOV [IL]; EINI MEIR [IL]; FRIEDMAN DORON [IL]; BERMAN TAL [IL]; BESONOV ALEX [IL]

Title: Buccal Delivery System

Application No.: 11/910902 Applic. Date: 2006-04-07

Abstract: A buccal delivery system capable of being blended in a normal dry powder process and compressed using a standard tabletting machine, said buccal delivery system comprising a matrix of: (a) an effective amount of one or more active ingredients

(b) an amount of one or more polyethylene glycols or derivatives thereof having a molecular weight between 1000 to 8000 sufficient to provide the required hardness and time for dissolution of the matrix

(c) 0.05-2% by weight of the total matrix of one or more suspending agents

(d) 0.05-2% by weight of the total matrix of one or more flowing agents

and (e) 0.05-2% by weight of the total matrix of one or more sweeteners.

Priority: AU20050901758 Applic. Date: 2005-04-08; WO2006AU00472 Applic. Date: 2006-04-07

Inventor: HEWITT ERNEST ALAN [AU]; STENLAKE RICHARD JAMES [AU]

Title: Permanently-Affixed Lens Cap

Application No.: 11/772214 Applic. Date: 2007-06-30

Abstract: A permanently-affixed lens cap is presented here. This is a lens cap which one does not have to separate from the camera, to use the camera. Unlike the existing lens caps which clip on the front, and are then removed, these caps remain on the front of the lens practically at all the times. Thus, they do not get lost, and the camera/lens is much safer because of it. Some of the features are: Crystal Clear: a Lens cover which looks like a filter, in that it screws into the filter thread at the end of the lens. This protects the expensive lens from impact and scratches. As an option, the user never has to remove it. Nano-Technology coating: Two separate layers of fine silica particles prevent scratches, and fluorine-containing resins in each layer repel ink marks. This has been used for DVD protection in the industry. Bullet-Proof: Layers of glass and (clear) plastic sandwiched to give great optical clarity, but an incredibly impact resistant front. Non-clear lens, which is permanently attached. The lens cap has a mechanism to flip out of the way. Press a button and the lens cap expands to become a shade, and exposes the front of the lens. Many other variations and extensions are also discussed in the specification and figures.

Inventor: LAW DAVID [US]; ESAREY GRAEME [US]; BUSCK JOHANNES REFSKUND [DK]

Title: DISTRIBUTED COAX PHOTOVOLTAIC DEVICE

Applicant/Assignee: SOLASTA INC

Application No.: 12/166920 Applic. Date: 2008-07-02

Abstract: A photovoltaic device includes a plurality of photovoltaic cells. Each photovoltaic cell of the plurality of photovoltaic cells includes a first electrode, a second electrode which is shared with at least one adjacent photovoltaic cell, and a photovoltaic material located between and in electrical contact with the first and the second electrodes. A thickness of the second electrode in a direction from one photovoltaic cell to an adjacent photovoltaic cell is less than an optical skin depth of the second electrode material, and a separation between first electrodes of adjacent photovoltaic cells is less than a peak wavelength of incident radiation.

Priority: US20070929578P Applic. Date: 2007- 07-03

Inventor: KEMPA KRZYSZTOF [US]; NAUGHTON MICHAEL [US]

Title: Cosmetic or dermopharmaceutical compositions containing kombucha

Applicant/Assignee: SEDERMA [FR]

Application No.: 12/231114 Applic. Date: 2008-08-29

Abstract: Cosmetic or dermopharmaceutical compositions which contain kombucha are disclosed. The present invention further relates to the use of kombucha and cosmetic or dermopharmaceutical compositions containing the same, alone or in combination, for the care of the skin, mucosae and skin appendages, and in particular for preventing the signs of endogenous and/or exogenous ageing.

Priority: FR20020009710 Applic. Date: 2002-07-30; US2005-523333 Applic. Date: 2005 -08-29; WO2003FR02368 Applic. Date: 2003-07-25

Inventor: LINTNER KARL [FR]

Title: Cosmetic or Dermopharmaceutical Composition Comprising an Euglena Extract

Applicant/Assignee: SEDERMA [FR]

Application No.: 11/795330 Applic. Date: 2006-01-13

Abstract: The invention provides a cosmetic or dermopharmaceutic composition containing an Euglena extract, its use to activate the cellular metabolism and in particular to protect and/or improve the state of the skin and to reduce the signs of ageing in particular and/or cutaneous fatigue

Priority: FR20050000431 Applic. Date: 2005-01-14; WO2006IB50135 Applic. Date: 2006-01-13

Inventor: LINTNER KARL [FR]; MAS CHAMBERLIN CLAIRE [FR]; LAMY LOUIS FRANCOIS [FR]; MONDON PHILIPPE [FR]

Title: COSMETIC PIGMENT COMPOSITION CONTAINING GOLD OR SILVER NANO-PARTICLES

Applicant/Assignee: KOREA RES INST OF BIOSCIENCE [KR]

Application No.: 11/995847 Applic. Date: 2006-02-13

Abstract: The present invention relates to a cosmetic pigment composition exhibiting colors in the visible region, which comprises an effective amount of nanoparticles or a mixture of two or more nanoparticles selected from the group consisting of (a) gold nanoparticles exhibiting red color

(b) silver nanoparticles exhibiting yellow color

(c) gold-silver alloy nanoparticles exhibiting flame color

and (d) gold nanoparticles exhibiting blue color, and a color cosmetic composition and a color lotion comprising the pigment composition. According to the present invention, it is possible to prepare pigments exhibiting various colors in the visible region using gold or silver nanoparticles, and a cosmetic pigment composition which can exhibit various colors by mixing the pigments in various compositional ratios, in which precipitation or agglomeration of particles does not occur, and whose color can be maintained for a long time. Also, since the pigment of the present invention is not harmful to the human body unlike conventional metal pigments, and contains gold or silver that is beneficial to health, the pigment can be used in various applications as functional raw materials.

Priority: KR20050064778 Applic. Date: 2005-07-18; WO2006KR00493 Applic. Date: 2006-02-13

Inventor: CHUNG BONG HYUN [KR]; LIM YONG TAIK [KR]; KIM JIN KYEONG [KR]; JEONG JIN YOUNG [KR]; HA TAI HWAN [KR]

Title: PARA-SUBSTITUTED 2-ALKOXYPHENOL COMPOUNDS

Application No.: 12/282349 Applic. Date: 2007-03-13

Abstract: Para- substituted 2-alkoxyphenols having cooling properties of formula (I) wherein R1 is methyl or ethyl

Y is, NH, O or S

R2 and R3 are independently of each other hydrogen or C1-3 alkoxy

n is 0 or 1

and the dotted line between C-2 and C-2' represents at least one of no bond, a single bond, or a (CH2)m- group, wherein m is 1 or 2. A process for their production and consumer products that have or use them are also disclosed.

Priority: US20060782466P Applic. Date: 2006-03-15; WO2007CH00135 Applic. Date: 2007-03-13

Inventor: GALOPIN CHRISTOPHE C [US]; FURRER STEFAN MICHAEL [US]; SLACK JAY PATRICK [US]; KRAWEC PABLO VICTOR [US]; COLE LUCIENNE [US]

Title: DOUBLE-STRANDED RNA OLIGONUCLEOTIDES WHICH INHIBIT TYROSINASE EXPRESSION

Applicant/Assignee: OREAL [FR]

Application No.: 12/252125 Applic. Date: 2008-10-15

Abstract: Novel double-stranded RNA oligonucleotides are useful for decreasing tyrosinase expression, have cosmetic and/or pharmaceutical applications, for example are useful skin depigmenting or anti-browning agents, and can be associated with cationic particles less than or equal to 1 mum in size, having a zeta potential of from 10 to 80 mV.

Priority: FR20050009658 Applic. Date: 2005-09-21; US2006-524315 Applic. Date: 2006-09- 21

Inventor: COLLIN-DJANGONE CHRISTINE [FR]; SIMONNET JEAN-THIERRY [FR]

Title: Loadable Polymeric Particles for Marking or Masking Individuals and Methods of Preparing and Using the Same

Applicant/Assignee: CELONOVA BIOSCIENCES INC [US]

Application No.: 11/928772 Applic. Date: 2007-10-30

Abstract: The present invention relates to the use of certain microspheres, nanospheres, and other structures to provide a method of marking or masking identifying marks in individual biological hosts. Biological hosts for the present invention may include humans, other animals, or plants. Such methods may be used to sense, signal, track, mark, or identify individual biological hosts. Microspheres, nanospheres, and other structures of the present invention may be implanted, injected, ingested, or attached to individual biological hosts. Microspheres, nanospheres, and other structures of the present invention comprise poly[bis(trifluoroethoxy)phosphazene] and/or a derivative thereof which may be present throughout the particles or within an outer coating of the particles. The microspheres, nanospheres, and other structures may also comprise a core having a hydrogel which may further comprise one or more dyes or other chromophoric agents covalently bound permanently to the hydrogel core material. The microspheres, nanospheres, and other structures and/or the hydrogel core may further comprise radio frequency or other electronic chips or nanochips, capable of transmitting and/or receiving electronic signals from external transmitters and/or receivers.

Inventor: FRITZ ULF [DE]; FRITZ OLAF [DE]; GORDY THOMAS A [US]; WOJCIK RONALD [US]

Title: NOVEL TOPICAL APPLICATION AGENTS AGAINST MIMIC AND AGE-RELATED WRINKLES

Applicant/Assignee: PENTAPHARM AG [CH]

Application No.: 11/718496 Applic. Date: 2005-11-01

Abstract: The compounds of formula (I) wherein X represents a bond or NH-CH(C-O)-(CH2)3+n-NH-R5, n represents 0, 1 or 2, R1, R4 and R5-independently from each other-represent hydrogen, possibly substituted C1-C6-alkyl, amidino or tetra-C1-C6-alkylamidinium, R2 represents hydrogen or possibly substituted C1-C6-alkyl or R1 and R2 together with the residue to which they are bound represent a 5- to 7-membered, saturated ring, R3 represents C1-C12-alkoxy, C1-C12-alkylamino, possibly substituted aryl-C1-C6-alkylamino, possibly substituted heteroaryl-C1-C6-alkylamino, possibly substituted aryl-C1-C6-alkoxy or possibly substituted heteroaryl-C1-C6-alkoxy, and R6 represents hydrogen or, when n is 1, also amino or together with R1 and the residue to which R6 and R1 are bound a 5- to 7-membered, saturated ring, as well as their physiologically acceptable salts are new. They can be manufactured according to common methods and processed to topically applicable compositions that are appropriate for treating mimic and age-related wrinkles in human skin.

Priority: CH20040001809 Applic. Date: 2004-11-02; WO2005CH00638 Applic. Date: 2005-11-01

Inventor: IMFELD DOMINIC [CH]; ZIEGLER HUGO [CH]; WIKSTROEM PETER [CH]

Title: Topical administration of at least one double-stranded RNA oligonucleotide (dsRNA)

Application No.: 12/007387 Applic. Date: 2008-01-09

Abstract: Expression of a messenger RNA which encodes a protein which is expressed by differentiated cells, notably the cells of the skin or appendages thereof, is inhibited by topically administering to said differentiated cells a thus effective amount of at least one double-stranded RNA oligonucleotide, formulated into a topically applicable, physiologically acceptable medium therefor

such regime or regimen is useful for treating a variety of afflictions or conditions, e.g., combating the signs of skin aging, stimulating hair growth or retarding loss thereof, inhibiting cellular proliferation and/or differentiation, etc.

Priority: FR20020006796 Applic. Date: 2002-06-03; US2004-001085 Applic. Date: 2004-12-02; WO2003FR01648 Applic. Date: 2003-06-02

Inventor: DURANTON ALBERT [FR]; COLLIN-DJANGONE CHRISTINE [FR]; PRUCHE FRANCIS [FR]; SIMONNET JEAN-THIERRY [FR]

Title: COMPOSITION COMPRISING AT LEAST ONE NUCLEOSIDIC MOIETY AS A THERAPEUTIC AGENT, AND CKC

Applicant/Assignee: NOVAGALI PHARMA SA [FR]

Application No.: 11/939840 Applic. Date: 2007-11-14

Abstract: Composition comprising at least one nucleosidic moiety and cetalkonium chloride and pharmaceutical use thereof for prevention, treatment or relief of eye, lung, and/or respiratory tract conditions.

Inventor: LAMBERT GREGORY [FR]; LALLEMAND FREDERIC [FR]

Title: NANO-CELLULAR POLYMER FOAM AND METHODS FOR MAKING THEM

Application No.: 11/623910 Applic. Date: 2007-01-17

Abstract: A nano-cellular polymer foam is disclosed, which has an average pore size from about 10 nanometers to about 500 nanometers

and a foam density that is from about 1 percent to about 50 percent of the bulk density of the material of the nano-cellular foam.

Inventor: THIAGARAJAN CHINNIAH [IN]; SRIRAMAN RAVI [IN]; CHAUDHARI TANSEN DHANANJAY [IN]; KUMAR MUNIRATNAM [IN]; SINHA VLKASH KUMAR [IN]; PATTANAYAK ASIM [IN]

Title: Personal cleansing kit for promoting relaxation and sleep, reducing stress and decreasing muscle tightness

Application No.: 12/001411 Applic. Date: 2007-12-11

Abstract: The present invention relates to a personal cleansing kit, that when used according to the instructions, provides a reduction in stress levels and muscle tightness, and improved sleep and relaxation. In one embodiment the personal cleansing kit comprises an article of commerce, a musical recording

and a heated cream. In another embodiment, the personal cleansing kit comprises an article of commerce an aroma releasing composition and a heated cream. In another embodiment, the personal cleansing kit comprises an article of commerce an aroma releasing composition, a musical recording and a heated cream. The article of commerce comprises a personal cleansing composition contained within a container and a set of instructions in association with said container. The set of instructions includes a breathing step, a stretching step and a massaging step.

Inventor: ADKISON EMILY KATHLEEN [US]; BRENNOCK JUNE TURKANIS [US]; RODRIGUEZ VICTOR RUBEN [US]

Title: COSMETIC OR DEMOPHARMACEUTICAL COMPOSITION COMPRISING ENKEPHALIN-DERIVED PEPTIDES TO REDUCE AND/OR ELIMINATE FACIAL WRINKLES

Applicant/Assignee: LIPOTEC SA [ES]

Application No.: 11/910719 Applic. Date: 2006-03-29

Abstract: The invention relates to a cosmetic or dermopharmaceutical composition comprising enkephalin-derived peptides for reducing and/or eliminating facial wrinkles. Said cosmetic or dermopharmaceutical composition for application in the skin, preferably in the skin of the face, to reduce and/or eliminate facial wrinkles, preferably facial expression wrinkles and comprises a cosmetically or dermopharmaceutically effective amount of a peptide of general formula (I). The invention also relates to the use of the peptide of general formula (I) in the preparation of a cosmetic or dermopharmaceutical composition reducing and/or eliminating facial wrinkles.

Priority: ES20050000824 Applic. Date: 2005-04-08; WO2006ES00151 Applic. Date: 2006-03-29

Inventor: FERRER MONTIEL ANTONIO [ES]; CEBRIAN PUCHE JUAN [ES]; PUIG MONTIEL ARTURO [ES]

Title: Cosmetic Composition for Stimulating the Synthesis of Proteins of the Basement Membrane

Applicant/Assignee: DSM IP ASSETS BV [NL]

Application No.: 12/226191 Applic. Date: 2006-04-28

Abstract: Cosmetic composition which can be applied topically, comprising at least one compound of the general formula (I) in which R1 is H, C1-C20-alkyl, cycloalkyl or aryl-C1-C4-alkyl, n is 1-4, X is -O-, -NH- or -NR2- and R2H or C1-C20-alkyl

and at least one compound corresponding to the above formula (I) but in which XR1 with X having the possible meaning of -NH- is the residue of an alpha-amino acid

use of these compounds and of the composition for stimulating the synthesis of the proteins of the basement membrane

and also both those compounds of the formula (I) in which X is -NR2- and both R1 and R2 are different from H, and the compounds corresponding to formula (I) but in which XR1 with X having the possible meaning of -NH- is the residue of an alpha-amino acid, as such.

Priority: WO2006EP03998 Applic. Date: 2006-04-28

Inventor: ZIEGLER HUGO [CH]; IMFELD DOMINIK [CH]; STOCKLI MARTIN [CH]; HEIDL MARC [DE]

Title: Glucan Compositions

Application No.: 12/085271 Applic. Date: 2006-11-20

Abstract: A cosmetic or pharmaceutical composition is provided comprising: a) 0.001 to less than 0.2% by weight, based on the weight of the total composition, of a scleroglucan having a mean molecular weight of 1x106 to 12x106

b) a cosmetically or pharmaceutically acceptable carrier

and, optionally, c) lactic acid, a lactate and/or pentanediol. The composition shows advantageous effects, such as moisturization of skin or mucosa, and has an antiaging and revitalizing effect on the skin. When combined with a certain bactericide as explained in claim 1, compositions containing native polysaccharides of the glucan class in general, especially of the scleroglucan as of component a), are well suitable to reduce the number of bacteria in mucosal or oral environments and minimise adhesion, while retaining a pleasant feeling on the mucosa or gingiva. Plaque thus can be efficiently prevented or removed.

Priority: EP20050111504 Applic. Date: 2005- 11-30; EP20060116766 Applic. Date: 2006-07-07; WO2006EP68645 Applic. Date: 2006-11-20

Inventor: BASCHONG WERNER [CH]; MONGIAT SEBASTIEN [FR]; OCHS DIETMAR [DE]

Title: TOPICALLY APPLICABLE COMPOSITION FOR USE AS A SKIN BLEACHING AGENT

Applicant/Assignee: DSM IP ASSETS BV [NL]

Application No.: 12/089654 Applic. Date: 2006-10-09

Abstract: Topical composition for use especially as a skin lightener, characterized in that it contains an effective amount of at least one compound of general formula (I) or a mixture of such compounds and/or an acid addition salt thereof: in which X is NH or a direct bond and n is 2, 3 or 4, preferably 2 or 3, and its use for lightening skin colour, for depigmenting liver spots and for evening out non-uniformities in skin colouration. The invention further relates to dermatologically effective compositions containing at least one disulfide of general formula (I) and at least one additional skin care ingredient.

Priority: CH20050001656 Applic. Date: 2005-10-12; WO2006CH00555 Applic. Date: 2006-10-09

Inventor: ZIEGLER HUGO [CH]; WIKSTROEM PETER [CH]; STOCKLI MARTIN [CH]

Title: Compositions and Methods of Use for Antibodies of c-Met

Applicant/Assignee: NOVARTIS AG

Application No.: 12/295535 Applic. Date: 2007-03-29

Abstract: Antibodies and fragments that bind to the protein target c-Met, particularly to epitopes located in the c-Met extracellular domain, are provided, as are methods of use of the antibodies and kits, for treating an unwanted cell, in particular, a cell associated with a c-Met-related condition such as a cancer, a metastasis, or an inflammatory condition.

Priority: US20060787556P Applic. Date: 2006-03- 30; WO2007US07543 Applic. Date: 2007-03-29

Inventor: STOVER DAVID RAYMOND [US]; PRASSLER JOSEF [DE]; BERGER CATRIN [DE]; BROCKS BODO [DE]

Title: INTEGRATED INTRA-DERMAL DELIVERY, DIAGNOSTIC AND COMMUNICATION SYSTEM

Applicant/Assignee: NEW WORLD PHARMACEUTICALS LLC [US]

Application No.: 12/337417 Applic. Date: 2008-12-17

Abstract: In one embodiment, an IDDC system utilizes an intelligent therapeutic agent delivery system comprised of one, but more likely an array of "cells" containing therapeutic agent(s) and/or diagnostic agents(s)

an integrated bio-sensing system designed to sample and analyze biological materials using multiple sensors that include both hardware and software components. The software component involves biomedical signal processing to analyze complex liquid mixtures and a microcontrollers) acts as interface to the biosensors, to the therapeutic delivery elements, and to a communications system(s) for the purpose of controlling the amount of therapeutic agent to deliver and also to provide information in a useful form to interested parties on the progress of therapy and compliance thereto. The synergistic effect of combining the above describe elements is expected to dramatically improve patient compliance with prescribed therapy, quality and timeliness of care provided by physicians, and at the same time reduce the cost of providing effective healthcare to IDDC system users, thereby improving profitability for Managed Care organizations and pharmaceutical companies utilizing the system.

Priority: US20070014184P Applic. Date: 2007-12-17; US20080023972P Applic. Date: 2008-01-28

Inventor: SEXTON FREDERICK A [US]; SUNI IAN IVAR [US]; CETINKAYA CETIN [US]; SCHUCKERS STEPHANIE [US]; SAZONOV EDUARD [US]

Title: Implant for Tissue Engineering

Application No.: 12/342812 Applic. Date: 2008-12-23

Abstract: The present invention relates to uses of resorbable medical implants that are metallic or semi-metallic, to produce soft tissues, membranous tissues, organs or organ parts within the body by fibrosis. The present invention further relates to such uses when the implants are made of specified alloys or metals, e.g. magnesium and its alloys. The present invention further relates to such uses when the implant is surface modified. The present invention further relates to such uses when the implant is pre-implanted at another part of the body before implantation into the target site.

Priority: US20080021709P Applic. Date: 2008-01-17

Inventor: IP WING YUK [CN]; YUEN CHI KEUNG [CN]

Title: Pyridinylamines

Applicant/Assignee: GPC BOTECH AG [DE]

Application No.: 11/659013 Applic. Date: 2005-08-01

Abstract: Described are pyridinylamines and pharmaceutically acceptable salts thereof, the use of these pyridinylamines for the prophylaxis and/or treatment of various diseases such as infectious diseases, including opportunistic infections, prion diseases immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, as well as pharmaceutical compositions containing at least one pyridinylamine and/or pharmaceutically acceptable salts thereof. Furthermore, reaction procedures for the synthesis of the pyridinylamines are disclosed.

Priority: EP20040018131 Applic. Date: 2004-07-30; US20040599307P Applic. Date: 2004-08-06; WO2005EP08321 Applic. Date: 2005-08-01

Inventor: EICKHOFF JAN ELKE [DE]; HAFENBRADL DORIS [DE]; SCHWAB WILFRIED [DE]; COTTON MATTHEW [GM]; KIEBL BERT MATTHIAS [DE]; ZECH BIRGIT [DE]; MULLER STEFAN [DE]; HARRIS JOHN [GB]; SAVIC VLADIMIR [SA]; MACRITCHIE JACKIE [GB]

Title: NANO- STRUCTURED THIXOTROPIC INORGANIC PEELING GELS

Applicant/Assignee: MBS S R L [IT]

Application No.: 11/795853 Applic. Date: 2006-01-24

Abstract: A composition, a method, and a kit are provided for chemical skin peeling, based on nano-structured thixotropic inorganic gels, which have a higher potency and are less irritant of the conventional peeling formulations. The gels of the invention can easily be applied on the skin, where they form a stable, uniform layer, that doesn't strain. The kit comprises by a defatting gel, different types of peeling gels and a neutralizing gel. The defatting gel is characterized by a markedly enhanced defatting capacity in comparison to the conventional products, because the sebum solubilized by the solvent is strongly adsorbed on the huge surface of the nano-structured material of the gel. The peeling gels are based on conventional peeling compounds, such as glycolic acid, trichloroacetic acid, pyruvic acid, salicylic acid, Jessner solution, but the presence of nano-structured material strongly increases the peeling effect, allowing the use of lower concentrations of peeling compound, with only minimal skin irritation for the user. The neutralizing gel is characterized by a colour change that allows the operator to verify in real time the neutralization of the peeling agent on the treated skin surface. All the gels of the invention can be easily removed from the skin after the treatment. The thixotropic gels of the invention can be used in chemical skin peeling for the treatment of various cosmetic conditions and dermatological disorders, including dry skin, acne, dandruff, keratoses, age spots, wrinkles and disturbed keratinisation.

Priority: IT2005NA00003 Applic. Date: 2005-01-24; WO2006EP00568 Applic. Date: 2006-01-24

Inventor: DE ROSA MARIO [IT]

Title: Composite, Method of Producing the Composite and Uses of the Same

Applicant/Assignee: UNIV SINGAPORE [SG]

Application No.: 11/664164 Applic. Date: 2005-09-29

Abstract: The invention relates to a composite comprising a semi- permeable barrier layer that is permeable to oxygen and impermeable to moisture

and a scaffold fiber layer formed by electrospinning fibers on one side of the barrier layer.

Priority: US20040614431P Applic. Date: 2004-09-29; WO2005SG00323 Applic. Date: 2005-09-29

Inventor: CHONG EE JAY [SG]; LIM CHWEE TECK [SG]; RAMAKRISHNA SEERAM [SG]; PHAN TOAN THANG [SG]; LIM IVOR JIUN [SG]

Title: Compounds for Photochemotherapy

Applicant/Assignee: UNIV GENEVE [CH]

Application No.: 11/914446 Applic. Date: 2006-05-15

Abstract: Enzyme-activatable photosensitizing polymer conjugates are disclosed for photochemotherapeutic treatment of human diseases and disorders, bacteriologic or virologic indications, cosmetic applications and other pathologic situations. These polymer conjugates may comprise a polymer carrier, a photosensitizer, a quencher, a targeting molecule and/or a biocompatibilizing unit. These macromolecular conjugates may be designed to guide to the target tissue a photosensitizing agent in an inactive, non-phototoxic form. However, upon entering the target environment, in which certain enzymes are presently active, the conjugate may release its photosensitizers in its fully active form, resulting in a highly localized activation of the photoactive agent. Also described here are methods, compositions and kits for the preparation and testing of such photochemotherapcutic conjugates.

Priority: US20050681244P Applic. Date: 2005-05-16; WO2006IB03547 Applic. Date: 2006-05-15

Inventor: LANGE NORBERT [CH]; CAMPO MARINO A [CH]

Title: Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development

Application No.: 12/387239 Applic. Date: 2009-04-30

Abstract: The present invention relates to prevention of congenital deformations. The invention further relates to cancer inhibition and prevention. The invention further relates to methods and compositions to modulate, antagonize, or agonize disparate signaling pathways that may converge to regulate patterning events and gene expression during prenatal development, post-natal development, and during development in the adult organism.

Priority: US2006-591398 Applic. Date: 2006-11-01; US2007-001869 Applic. Date: 2007-12-13

Inventor: JENNINGS BARBARA BROOKE [US]

Title: Topical use of teprenone

Applicant/Assignee: SEDERMA [FR]

Application No.: 11/920322 Applic. Date: 2006-05-12

Abstract: Topical use of teprenone in a cosmetic or dermopharmaceutical composition as an active preventing and/or limiting the skin cells sénescence and/or protecting the general state of the skin.

Priority: FR20050004869 Applic. Date: 2005-05-13; WO2006IB51497 Applic. Date: 2006-05-12

Inventor: LINTNER KARL [FR]; MAS CHAMBERLIN CLAIRE [FR]

Title: SEMICONDUCTOR LIGHT EMITTING DEVICES INCLUDING A LUMINESCENT CONVERSION ELEMENT AND METHODS FOR PACKAGING THE SAME

Applicant/Assignee: CREE INC

Application No.: 12/398626 Applic. Date: 2009-03-05

Abstract: Methods of packaging a semiconductor light emitting device include dispensing a first quantity of encapsulant material into a cavity including the light emitting device. The first quantity of encapsulant material in the cavity is treated to form a hardened upper surface thereof having a selected shape. A luminescent conversion element is provided on the upper surface of the treated first quantity of encapsulant material. The luminescent conversion element includes a wavelength conversion material and has a thickness at a middle region of the cavity greater than proximate a sidewall of the cavity.

Priority: US2005-055194 Applic. Date: 2005-02-10; US20040558314P Applic. Date: 2004-03-31; US20040637700P Applic. Date: 2004-12-21

Inventor: LEUNG MICHAEL [US]; COLEMAN THOMAS G [US]; BECERRA MARYANNE [US]

Title: Active nanoparticles and method of using

Applicant/Assignee: STC UNM

Application No.: 12/313847 Applic. Date: 2008-11-25

Abstract: Active multifunctional nanoparticles provide significant enhancement of the efficacy of model therapeutic and gene agents due to increased diffusion and penetration through mucus and biological barriers under the influence of a magnetic field.

Priority: US20070004324P Applic. Date: 2007-11-26

Inventor: SMYTH HUGH D [US]; OSINSKI MAREK [US]; MCGILL SHAYNA L [US]

Title: METHOD AND PROCESS FOR THE PRODUCTION OF MULTI-COATED RECOGNITIVE AND RELEASING SYSTEMS

Applicant/Assignee: UNIV TEXAS [US]

Application No.: 12/328469 Applic. Date: 2008-12-04

Abstract: The present invention includes compositions, methods, systems for the controlled delivery of an active agent within a polymeric network upon the binding of a molecule that decreases the structural integrity of the polymeric network at one or more micro- or nanovacuoles.

Priority: US2008-047309 Applic. Date: 2008-03-12

Inventor: PEPPAS NICHOLAS A [US]

Title: Detection of a Target in a Preservative Solution

Application No.: 12/408179 Applic. Date: 2009-03-20

Abstract: This invention relates to methods, articles and compositions useful in detecting target substances in an alcoholic preservative solution, and for identifying sensors useful for binding to such targets. The methods allow for the simultaneous performance of sufficient fixation of a sample and binding of a detectable sensor to a target of interest in the sample. In one aspect, a method is provided that comprises contacting a sample suspected of containing a target with a detectable sensor molecule known to bind to such target in an alcoholic preservative solution. The method maybe performed in multiplex form to permit simultaneous analysis of a plurality of targets. Methods for identifying a sensor capable of binding to a desired target in an alcoholic preservative solution are also provided. An alcoholic preservative solution comprising one or more such detectable sensors is also provided. Also provided is a sample comprising a bound sensor provided by such a process. Also provided are kits useful for such methods.

Priority: US2003-618443 Applic. Date: 2003-07-11; US2001-825482 Applic. Date: 2001-04-03; US20000194304P Applic. Date: 2000-04-03; US20000225524P Applic. Date: 2000-08-15

Inventor: LINDER JAMES [US]; COHENFORD MENASHI [US]; COFFMAN ERIN [US]; LENTRICHIA BRIAN B [US]; STENDER HENRIK [DK]; OLIVEIRA KENNETH [US]

Title: TARGETING CONTRAST AGENTS OR TARGETING THERAPEUTIC AGENTS FOR MOLECULAR IMAGING AND THERAPY

Applicant/Assignee: KONINKL PHILIPS ELECTRONICS NV [NL]

Application No.: 11/721382 Applic. Date: 2005-12-12

Abstract: This invention discloses a method of synthesizing targeting contrast agents for molecular imaging and targeting diagnosis and therapy, targeting contrast agents and targeting therapeutic agents and their use.

Priority: EP20040106694 Applic. Date: 2004-12-17; WO2005IB54185 Applic. Date: 2005-12-12

Inventor: HUMMEL HELGA [DE]; WEILER VOLKER ULRICH [DE]; HOFFMANN RALF [DE]

Title: Method for Constructing Functional Living Materials, Resulting Materials and Uses Thereof

Application No.: 12/227216 Applic. Date: 2007-05-16

Abstract: The invention concerns a method for constructing a functional living biomaterial, characterized in that it consists in assembling layer by layer (3D) a matrix and 2D layers of functional living cells by controlling their interactions and 3D structuring based on the desired organization and final shape of the biomaterial, wherein each layer has its own pattern adapted to the neighbouring layers and on the functionality of whole synthetic biomaterials. The invention is useful in the field of biomedicine and nanobiotechnology.

Priority: FR20060004358 Applic. Date: 2006-05-16; WO2007FR00836 Applic. Date: 2007-05-16

Inventor: DECHER GERO [DE]; FELIX OLIVIER [FR]; SAULNIER BENJAMIN [FR]; IZQUIERDO ALBERT [FR]; VOEGEL JEAN-CLAUDE [FR]; SCHAAF PIERRE GILBERT [FR]; JESSEL NADIA [FR]; BALL VINCENT PAUL [FR]

Title: TARGETING AGENTS FOR MOLECULAR IMAGING

Applicant/Assignee: KONINKL PHILIPS ELECTRONICS NV [NL]

Application No.: 11/721379 Applic. Date: 2005-12-12

Abstract: This invention discloses a method of synthesizing targeting contrast agents for molecular imaging and targeting diagnosis and therapy, targeting contrast agents and targeting therapeutic agents and the use thereof.

Priority: EP20040106696 Applic. Date: 2004-12-17; WO2005IB54187 Applic. Date: 2005-12-12

Inventor: HUMMEL HELGA [DE]; WEILER VOLKER ULRICH [DE]

Title: NANOSEGREGATED SURFACES AS CATALYSTS FOR FUEL CELLS

Applicant/Assignee: UCHICAGO ARGONNE LLC

Application No.: 12/338736 Applic. Date: 2008-12-18

Abstract: A method of preparing a nanosegregated Pt alloy having enhanced catalytic properties. The method includes providing a sample of Pt and one or more of a transition metal in a substantially inert environment, and annealing the sample in such an environment for a period of time and at a temperature profile to form a nanosegregated Pt alloy having a Pt-skin on a surface. The resulting alloy is characterized by a plurality of compositionally oscillatory atomic layers resulting in an advantageous electronic structure with enhanced catalytic properties.

Priority: US20070008605P Applic. Date: 2007-12-20

Inventor: STAMENKOVIC VOJISLAV [US]; MARKOVIC NENAD M [US]

Title: NUTRITIONAL SUPPLEMENT FOR THE PREVENTION OF CARDIOVASCULAR DISEASE, ALZHEIMER'S DISEASE, DIABETES, AND REGULATION AND REDUCTION OF BLOOD SUGAR AND INSULIN RESISTANCE

Application No.: 12/390302 Applic. Date: 2009-02 -20

Abstract: A mixture (which may be utilized as a food or a drink or a supplement or a drug or a cosmetic or a hygienic product) that is formulated and is capable of improving a person's well being, lowering the risks of cardiovascular and/or Alzheimer's diseases and/or lowering blood sugar using natural and synthetic ingredients. Numerous ratios of ingredients may be formulated to balance synergy resonance of antioxidants, flow (viscosity), sediment/uniformity, color, taste, sugar content, flavor and aroma. Moreover, ingredients for natural preservatives and sugar substitutes and methods of nano-dispersion, nano-encapsulation, time-released delivery and apparatus for personalized nutrition are also described herein.

Priority: US20080043059P Applic. Date: 2008-04-07

Inventor: MAZED MOHAMMAD A [US]; MAZED SAYEEDA [IN]

Title: USE OF PROTOBERBERINES AS AN ACTIVE SUBSTANCE REGULATING THE PILOSEBACEOUS UNIT

Applicant/Assignee: SEDERMA [FR]

Application No.: 11/991587 Applic. Date: 2006-09-06

Abstract: The present invention relates to cosmetic use, by topic application on the skin of at least one protoberberine, with exception of berberine, or a vegetable extract containing it, as an active substance reducing activity of the pilosebaceous unit, preferably inhibiting activity of the pilosebaceous unit. In particular, the invention relates to cosmetic use of at least one protoberberine, with exception of berberine, or a vegetable extract containing it, as an agent reducing, preferably inhibiting the growth of hairs of the face and/or the body, and/or seborrheic activity of the sebaceous glands. The invention also relates to a cosmetic composition comprising in a dermatologically acceptable carrier, at least one protoberberine, with exception of berberine, or a vegetable extract containing protoberberines, as an active substance, which reduces, preferably inhibits the skin's pilosebaceous unit activity.

Priority: FR20050009100 Applic. Date: 2005-09-06; WO2006IB53136 Applic. Date: 2006-09-06

Inventor: LINTNER KARL [FR]; MAS CHAMBERLIN CLAIRE [FR]

Title: COSMETIC AND DERMATOLOGICAL FORMULATIONS OF MNTF PEPTIDES

Applicant/Assignee: DERMACARE NEUROSCIENCES INST [US]

Application No.: 12/391243 Applic. Date: 2009-02-23

Abstract: The disclosure is directed to methods and compositions that include MNTF peptides and their analogs for cosmetic and dermatological purposes.

Priority: US20080066670P Applic. Date: 2008-02-21

Inventor: KO PUI-YUK DOROTHY [US]

Title: Imaging Agents

Application No.: 11/992292 Applic. Date: 2006-09 -22

Abstract: The use of silicon as an imaging agent is described.

Priority: GB20050019391 Applic. Date: 2005-09-22; WO2006GB03522 Applic. Date: 2006-09-22

Inventor: CANHAM LEIGH TREVOR [GB]; KLUCZEWSKA ANNA AGNIESZKA [AU]; BARLEY JEROME PAUL [AU]; VARAJAO RAPHAELA FORTES DRUMMO [AU]

Title: Mixtures Comprising Anthranilic Acid Amides and Cooling Agents as Cosmetic and Pharmaceutical Compositions for Alleviating Itching

Applicant/Assignee: SYMRISE GMBH & CO KG [DE]

Application No.: 11/917370 Applic. Date: 2006-06-14

Abstract: The invention relates to a mixture comprising or consisting of: (a) one or more compounds of Formula 1: where the symbols in the compound or each compound of Formula 1 are defined as follows: m=0, 1, 2 or 3, p=0, 1 or 2, n=0, 1 or 2, where, when n=1 or 2, R1 and R2 in pairs are each H or together are another chemical bond, where, when m=1, 2 or 3, each X independently of the others is OH, Oalkyl or Oacyl, and where, when p=1 or 2, each Y independently of the others is OH, Oalkyl or Oacyl, and R3=H or alkyl, R3=H also representing the corresponding cosmetically or pharmaceutically acceptable salts and solvates

and (b) one or more cooling agents.

Priority: WO2006EP62520 Applic. Date: 2006-05-23; WO2006EP63175 Applic. Date: 2006-06-14; US20050690153P Applic. Date: 2005-06-14

Inventor: VIELHABER GABRIELE [DE]; SCHMAUS GERHARD [DE]; PILLAI RAVIKUMAR [US]