Title: Cosmetic compositions

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 10/883505   Filing Date: 01/Jul/2004

Abstract:Use of cosmetic compositions comprising an --hydroxyaldehyde self-tanning agent and a water-soluble vitamin B3 compound as a self-tanning composition are provided. The cosmetic compositions are useful for imparting a natural, even and durable tan to the skin when topically applied.

Priority:

Inventor: CROOK TERESA B [GB]; STEPHENS ALISON F [GB]

Title: Solubilization of triazine UV-screening agents with arylalkyl benzoate compounds/amide-based oils and photoprotective compositions comprised thereof

Applicant/Assignee: L'OREAL

Application No.: 11/172885   Filing Date: 05/Jul/2005

Abstract:Topcially applicable photoprotective compositions having improved sun protection factor, cosmetic properties and/or stability contain: (a) at least one 1,3,5-triazine UV-screening agent, (b) at least one mixture including: (i) at least one arylalkyl benzoate compound, and (ii) at least one oil containing in its structure at least one amide unit.

Priority: FR20040051421 Applic. Date: 2004-07-02; US20040589007P Applic. Date: 2004-07-20

Inventor: CANDAU DIDIER [FR]; FIANDINO CECILE [FR]

Title: Photostabilization of dibenzoylmethane UV-screening agents with arylalkyl benzoate compounds/amide-based oils and photoprotective compositions comprised thereof

Applicant/Assignee: L'OREAL

Application No.: 11/172902   Filing Date: 05/Jul/2005

Abstract:Topically applicable, photostable compositions with respect to UV radiation contain at least one dibenzoylmethane UV-screening agent and at least one arylalkyl benzoate compound and at least one amide-based oil.

Priority: FR20040051417 Applic. Date: 2004-07-02; US20040589010P Applic. Date: 2004-07-20

Inventor: CANDAU DIDIER [FR]

Title: Topical pharmaceutical composition to treat hyperpigmentation of the skin

Applicant/Assignee:

Application No.: 11/150821   Filing Date: 10/Jun/2005

Abstract:Provided is a topical pharmaceutical composition for skin lightening, which is particularly useful in treating skin hyperpigmentation, together with methods for its use. The composition and methods involve the topical use of an active agent effective in the treatment of skin hyperpigmentation plus a permeation-enhancing base that, in one embodiment, gives the composition a pH of about 8.0 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5.

Priority: US2000-607892 Applic. Date: 2000-06-30; US2002-178082 Applic. Date: 2002-06-21; US2001-972008 Applic. Date: 2001-10-04; US2000-738410 Applic. Date: 2000-12-14; US2000-569889 Applic. Date: 2000-05-11; US1999-465098 Applic. Date: 1999-12-16; US2000-738395 Applic. Date: 2000-12-14

Inventor: MAIBACH HOWARD I [US]; LUO ERIC C [US]; HSU TSUNG-MIN [US]

Title: Rinse-out cosmetic composition comprising elastomeric film-forming polymers, use thereof for conditioning keratin materials

Applicant/Assignee:

Application No.: 11/171315   Filing Date: 01/Jul/2005

Abstract:The present disclosure relates to a cosmetic composition comprising, in a cosmetically acceptable medium, at least one elastomeric film-forming polymer, wherein film obtained by drying the at least one elastomeric film-forming polymer at ambient temperature and at a relative humidity of 55%+-5%, has properties comprising: (a) an elongation at break (epsilonb) of greater than or equal to 800%, (b) an instantaneous recovery (Ri) at least equal to 75%, after an elongation of 150%, and (c) a recovery (R300) at 300 seconds of greater than 80%, the at least one elastomeric film-forming polymer being water-soluble. This composition makes it possible, for example, to condition keratin fibers such as the hair.

Priority: FR20040007305 Applic. Date: 2004-07-01; US20040587853P Applic. Date: 2004-07-15

Inventor: ROLLAT-CORVOL ISABELLE [FR]; GAWTREY JONATHAN [FR]

Title: Anti-ageing skin cosmetic

Applicant/Assignee:

Application No.: 10/520562   Filing Date: 07/Jan/2005

Abstract:The invention relates to a cosmetic based on various natural raw materials, which can be used to counter ageing processes of the human skin. The inventive cosmetic contains 0.1-5% by weight of an extract from a mixture of fig leaves and fruits, 0.1-3% by weight of an extract from pomegranate fruits, 0.001-0.5% by weight of a ground dry mixture of rosemary stems and leaves, 0.01-3% by weight of liposomes containing an extract from peeled musk melons, 0.1-5% by weight of liposomes containing a plankton extract containing the photolyase enzyme, 0.1-5% by weight of liposomes containing 0.1 to 0.5% by weight, in relation to the liposome weight, of a micrococcus lysate containing the UV-endonuclease enzyme

and up to 100% by weight, other active substances, carrier substances, adjuvants or mixtures thereof.

Priority: DE20021031468 Applic. Date: 2002-07-08; WO2003DE02157 Applic. Date: 2003-06-23

Inventor: GOLZ-BERNER KARIN [MC]; ZASTROW LEONHARD [MC]

Title: Agent for the anti-adhesion of skin pathogenic flora

Applicant/Assignee:

Application No.: 11/217930   Filing Date: 01/Sep/2005

Abstract:Bacterial agents for preparing compositions which are for cosmetic, pharmaceutical or veterinary use and which are intended to stabilize and/or regulate the cutaneous ecosystem of mammals. These bacterial agents are extracts of a bacterium, or a bacterium and are selected for their adhesion to skin cells and anti-adhesion to pathogens of the cutaneous system. The invention also relates to compositions containing such agents.

Priority: EP19990204489 Applic. Date: 1999-12-22; US2002-177589 Applic. Date: 2002-06-21; WO2000EP12719 Applic. Date: 2000-12-13

Inventor: BAUR MARKUS [DE]; ZINK RALF [CH]; AUZANNEAU ISABELLE [FR]; BUFFARD KARINE [FR]

Title: Treatment of complement-associated disorders

Applicant/Assignee:

Application No.: 11/159919   Filing Date: 22/Jun/2005

Abstract:The present invention concerns a recently discovered macrophage specific receptor, CRIg, and its use in the treatment of complement-associated disorders.

Priority: US2004-964263 Applic. Date: 2004-10-12; US1999-380138 Applic. Date: 1999-08-25; WO1999US05028 Applic. Date: 1999-03-08; WO1998US24855 Applic. Date: 1998-11-20; US19980078936P Applic. Date: 1998-03-20; US2004-767374 Applic. Date: 2004-01-29; US2004-767904 Applic. Date: 2004-01-29; US2001-953499 Applic. Date: 2001-09-14; WO2003US31207 Applic. Date: 2003-10-01; US2003-633008 Applic. Date: 2003-07-31; US2002-265542 Applic. Date: 2002-10-03; US1999-254465 Applic. Date: 1999-03-05

Inventor: ASHKENAZI AVI [US]; HELMY KARIM Y [US]; FONG SHERMAN [US]; GODDARD AUDREY [US]; GURNEY AUSTIN L [US]; KATSCHKE KENNETH J JR [US]; LOOKEREN MENNO V [US]; WOOD WILLIAM I [US]

Title: Dissolvable film composition

Applicant/Assignee:

Application No.: 11/158153   Filing Date: 21/Jun/2005

Abstract:A system, a kit and methods for delivering an effective amount of a labile active to the skin, comprising a composition comprising an effective amount of a labile active agent incorporated into a water-soluble polymeric film and an additive composition capable of dissolving the water-soluble polymeric film.

Priority: US20040581842P Applic. Date: 2004-06-22

Inventor: BEVACQUA ANDREW J [US]; LENTINI PETER J [US]; KEELER TRACY N [US]; ZECCHINO JULLES R [US]; VASSILIOU PAULINE [US]

Title: Antioxidants in clusters of structured water

Applicant/Assignee: COLOR ACCESS, INC

Application No.: 11/190567   Filing Date: 27/Jul/2005

Abstract:The invention relates to structured water and its antioxidant activity. In addition, the present invention relates to antioxidants incorporated within the cluster structure of either electropositive (S water) or electronegative (I water). The structured water, having the antioxidant within its cluster structure, has a stabilizing effect on the antioxidant. In addition, the antioxidant activity inherent to structured water is enhanced by the presence of the antioxidant within its cluster structure. The present invention also includes methods of removing or reducing free radicals on the skin and thereby preventing the signs of skin aging and the risks of cancer associated with the presence of free radicals in the skin.

Priority: US2002-183819 Applic. Date: 2002-06-27

Inventor: IONITA-MANZATU VASILE [US]; IONITA-MANZATU MIRELA [US]; CIOCA GHEORGHE [US]; BEVACQUA ANDREW J [US]

Title: Detergent composition with benefit agents

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 10/980478   Filing Date: 03/Nov/2004

Abstract:A water-in-oil emulsion system as a storage stable carrier of high pH sensitivity benefit agents or actives comprising i) an aqueous phase including at least one water soluble and/or dispersible benefit agent

ii) a hydrophobic protective carrier phase for the aqueous phase containing the benefit agent

and iii) an emulsifier or a dispersant. Also provided is a rinse off non-liquid cleansing composition comprising the water-in-oil emulsion system and a second phase which is a continuous alkaline phase.

Priority: IN2003MU01166 Applic. Date: 2003-11-06

Inventor: KRISHNAN VENKATESWARAN [IN]; SHAH PANKAJ C [IN]; SIVAKUMAR ANANTHASUBRAMANIAN [IN]

Title: Cosmetic/dermatological applications of LIF

Applicant/Assignee:

Application No.: 11/137344   Filing Date: 26/May/2005

Abstract:Leukemia inhibitory factor ("LIF"), an LIF analogue, an LIF mimetic, a product capable of stimulating the expression of endogenous LIF and mixtures thereof are useful for maintaining and/or stimulating the regenerative power of a population of human undifferentiated skin stem cells and/or epidermal progenitors, and are also useful for treating dry and/or chapped and/or aged skin and/or hair loss, as well as for treating skin burns and promoting skin regeneration and/or cicatrization.

Priority: FR20040051034 Applic. Date: 2004-05-26; US20050641434P Applic. Date: 2005-01-06

Inventor: FORTUNEL NICOLAS [FR]; BERNARD DOMINIQUE [FR]; FERRARIS CORINNE [FR]; REGNIER MARCELLE [FR]

Title: Compositions and methods for treating pathological infections

Applicant/Assignee:

Application No.: 11/172285   Filing Date: 30/Jun/2005

Abstract:The present invention relates to compositions and methods for treating pathological infections. An embodiment of the present invention is directed to a topical composition useful for the treatment of yeast, fungal or bacterial infections of a patient in need of such treatment which includes a pharmaceutically effective amount of an anti-yeast, anti-fungal or antibacterial pharmaceutically active agent

and a pharmaceutically acceptable carrier.

Priority: US20040589215P Applic. Date: 2004-07-02; US20040590813P Applic. Date: 2004-07-23

Inventor: MANANDHAR MADHUSUDAN P [US]

Title: Triple anti-irritant composition

Applicant/Assignee: MEDICIS PHARMACEUTICAL CORPORATION

Application No.: 10/884146   Filing Date: 02/Jul/2004

Abstract:The present invention relates to a composition comprising two or more anti-irritants, each having at least about 7.2% oxygen content. In a separate embodiment, the composition may be defined to include a skin conditioning agent, a skin protectant agent, and an anti-irritant agent, each having an oxygen content of at least about 7.2%. The invention further comprises methods of treating and preventing skin conditions by applying the composition to the skin, and then optionally washing the skin.

Priority:

Inventor: BHATIA KULJIT S [US]; PATEL BHIKU G [US]; GANS EUGENE H [US]

Title: Leave-in cosmetic composition comprising at least one elastomeric film-forming polymer and use thereof for conditioning keratin materials

Applicant/Assignee:

Application No.: 11/171211   Filing Date: 01/Jul/2005

Abstract:Disclosed is a leave-in cosmetic composition comprising, in a cosmetically acceptable medium, at least one elastomeric film-forming polymer chosen such that the film obtained by drying this polymer, in an aqueous or alcoholic medium, at ambient temperature and at a relative humidity of 55%, has a mechanical profile comprising: (a) an elongation at break (epsilonb) of greater than or equal to 800%, (b) an instantaneous recovery (Ri) at least equal to 75%, after an elongation of 150%, and (c) a recovery (R300) at 300 seconds of greater than 80%.

Priority: FR20040007304 Applic. Date: 2004-07-01; US20040587856P Applic. Date: 2004-07-15

Inventor: SAMAIN HENRI [FR]; ROLLAT-CORVOL ISABELLE [FR]; GAWTREY JONATHAN [FR]

Title: Cosmetic and dermatological photoprotective formulations

Applicant/Assignee: BEIERSDORF AG

Application No.: 11/087395   Filing Date: 23/Mar/2005

Abstract:Cosmetic or dermatological preparations which have a UVA balance of more than 15, and use thereof.

Priority: DE200410014614 Applic. Date: 2004-03-23; DE200410020627 Applic. Date: 2004-04-27

Inventor: DORING THOMAS [DE]; SUGAR MARTIN [DE]; WOLBER RAINER [DE]; WENDEL VOLKER [DE]; BLATT THOMAS [DE]; MUNDT CLAUDIA [DE]; SCHULZ JENS [DE]; BATZER JAN [DE]; DIPPE RIXA [DE]

Title: Method of promoting the penetration of a cosmetic active and composition therefore

Applicant/Assignee: L'OREAL

Application No.: 11/153380   Filing Date: 16/Jun/2005

Abstract:The invention relates to a method of promoting the penetration of a cosmetic active, wherein a composition in the form of a water-in-oil emulsion is applied topically, said emulsion comprising a fatty phase with a polarity ba greater than or equal to 0.1 and comprising a mixture of at least two oils, and in that the application of said emulsion is made simultaneously, with an interval or sequentially in time with the application of the cosmetic active.

Priority: FR20040006539 Applic. Date: 2004-06-16; US20040621804P Applic. Date: 2004-10-26

Inventor: SEYLER NATHALIE [FR]; GUIRAMAND CAROLE [FR]; RIBAUD CHRISTELE [FR]

Title: Photostabilization of dibenzoylmethane UV-screening agents with arylalkyl benzoate/bis-resorcinyl triazine compounds and photoprotective compositions comprised thereof

Applicant/Assignee: L'OREAL

Application No.: 11/172932   Filing Date: 05/Jul/2005

Abstract:Topically applicable, photostable compositions with respect to UV radiation contain at least one dibenzoylmethane UV-screening agent and at least one arylalkyl benzoate compound and at least one bis-resorcinyl triazine compound.

Priority: FR20040051419 Applic. Date: 2004-07-02; US20040589009P Applic. Date: 2004-07-20

Inventor: CANDAU DIDIER [FR]

Title: Photostabilization of dibenzoylmethane UV-screening agents with arylalkyl benzoate compounds and photoprotective cosmetic compositions comprised thereof

Applicant/Assignee: L'OREAL

Application No.: 11/172949   Filing Date: 05/Jul/2005

Abstract:Topically applicable cosmetic/dermatological photoprotective compositions contain at least one dibenzoylmethane UV-screening agent, and, as a photostabilizer therefor, at least one arylalkyl benzoate compound of formula (I) or (II) below: with the proviso that: (i) the subject compositions are characteristically devoid of any octyl methoxycinnamate

and (ii) same are other than a solution of butyl methoxydibenzoylmethane in 2-phenylethyl benzoate, 2-phenylethyl o-toluate, 2-phenylethyl p-toluate or in a 2-phenylethyl o-toluate/2-phenylethyl p-toluate (1/1) mixture.

Priority: FR20040051416 Applic. Date: 2004-07-02; US20040588984P Applic. Date: 2004-07-20

Inventor: CANDAU DIDIER [FR]

Title: Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss, composition comprising it and its uses

Applicant/Assignee: SOCIETE L'OREAL S.A L'OREAL

Application No.: 10/671508   Filing Date: 29/Sep/2003

Abstract:Heterocyclic compounds useful for stimulating/inducing the growth of keratinous fibers, notably human hair/eyelashes, and/or slowing the loss of same, have the following structural formula (I) or salt thereof: in which Hy is a heterocycle of 4 to 7 atoms, optionally comprising carbonyl/thiocarbonyl functional groups, and G is O, S or NH.

Priority: FR20020012018 Applic. Date: 2002-09-27; US20020415462P Applic. Date: 2002-10-03

Inventor: BOULLE CHRISTOPHE [FR]; ROZOT ROGER [FR]; DALKO MARIA [FR]

Title: Hair and skin care composition

Applicant/Assignee:

Application No.: 10/885166   Filing Date: 06/Jul/2004

Abstract:The present invention provides cosmetic compositions that form a durable film or coating on surfaces such as hair or skin. The compositions of the invention comprise one or more anionic silicones and one or more high molecular weight esters, the combination of which provides a durable film. Methods for treatment of hair and skin employing the compositions of the invention are also provided.

Priority:

Inventor: ROBINSON FREDA E [US]; BUCKRIDGE KENNETH [US]; FLEISSMAN LEONA G [US]

Title: Multi-phased personal care composition

Applicant/Assignee:

Application No.: 11/178047   Filing Date: 08/Jul/2005

Abstract:The present invention is a multi-phased personal care composition that contains at least two visually distinct phases. At least one of the visually distinct phases is a benefit phase that has a Flow Onset Temperature of at least about 97 DEG F.

and wherein said visually distinct phases form a pattern

and wherein said visually distinct phases are packaged in physical contact with one another and are stable.

Priority: US20040586740P Applic. Date: 2004-07-09

Inventor: VELARDE ANDRES E [US]; HEDGES STEVEN K [US]; SMITH EDWARD D III [US]; WEI KARL S [US]

Title: Method of skin care and/or treatment using thioredoxin

Applicant/Assignee:

Application No.: 11/179170   Filing Date: 12/Jul/2005

Abstract:Methods for the prevention and treatment of skin damage arising from the exposure to UV radiation and other stressors capable of leading to the formation of free radicals, using the small dithiol protein thioredoxin in a dermatologically acceptable carrier that can be applied topically are disclosed. Some embodiments may include other proteins such as superoxide dismutase and/or catalase, as well as other antioxidant molecules such as reduced glutathione, vitamin E, vitamin C, lycopene, astaxanthin and/or tocotrienols.

Priority: US20040587217P Applic. Date: 2004-07-12

Inventor: SIVAK HANNAH N [US]; IGLESIAS ALBERTO A [AR]; BALLICORA MIGUEL A [US]

Title: Compositions comprising gelatin-glycine and carotenoids

Applicant/Assignee: MAVI SUD S.R.L

Application No.: 11/177500   Filing Date: 11/Jul/2005

Abstract:The invention relates to cosmetic and pharmaceutical agents and compositions useful in the treatment of those phenomena and manifestations generally causing or accompanying the aging of skin, ocular tissues and other tissues. In particular the invention relates to the use of different mixture of carotenoids, preferably lutein, and gelatin-glycine for improving hydration, elasticity and lipid content of the skin and for protecting skin and ocular tissues from hazardous radiations.

Priority: EP20040103266 Applic. Date: 2004-07-09

Inventor: MORGANTI PIERFRANCESCO [IT]; ROBERTS RICHARD L [US]

Title: Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes

Applicant/Assignee:

Application No.: 11/168017   Filing Date: 27/Jun/2005

Abstract:Acne-affected skin has been found to be accompanied by the presence of matrix-degrading enzymes such as MMPs and neutrophil elastase, induction of neutrophils, and a reduction in procollagen biosynthesis. This invention treats scarring and inflammation accompanying acne by administering, topically or systemically, at least one of (i) an inhibitor of the matrix degrading enzymes and (ii) a cytokine inhibitor that alleviates inflammation and thus also alleviate neutrophil infiltration. Alleviating the matrix degradation and renormalizing procollagen biosynthesis allows for reduced inflammation and better natural repair of acne-affected skin. Inhibiting cytokines alleviates induction of MMPs in resident skin cells, and also alleviates inflammation with its concommitant induction of neutrophils from the blood stream bringing MMPs and elastase into the acne lesion. Dimishing the presence of matrix-degrading enzymes in the acne lesion reduces imperfect repair of the skin and thus decreases scarring in acne-affected skin.

Priority: US2001-852154 Applic. Date: 2001-05-09; US2000-576597 Applic. Date: 2000-05-22; US19990134984P Applic. Date: 1999-05-20

Inventor: VOORHEES JOHN J [US]; KANG SEWON [US]; FISHER GARY J [US]

Title: Method for providing customized products

Applicant/Assignee:

Application No.: 11/176138   Filing Date: 07/Jul/2005

Abstract:In a first aspect a method for producing a customized product is disclosed. The method includes providing a high internal phase emulsion, providing at least one other component of a customized product, generating a customized product formula based at least in part on consumer data and mixing the emulsion with the at least one other component in accordance with the customized product formula to produce the customized product. In a second aspect, a method of manufacturing a customized personal product using an oil-in-water high internal phase emulsion is disclosed.

Priority: US20040586603P Applic. Date: 2004-07-09

Inventor: DECKNER GEORGE E [US]

Title: Transdermal drug delivery formulations and method of determining optimal amounts of vasodilators therein

Applicant/Assignee:

Application No.: 10/893733   Filing Date: 16/Jul/2004

Abstract:A method for determining and demonstrating the role of vasodilator chemical agents in the development and practice of transdermal drug delivery systems. Vasodilator chemicals applied topically dilate the blood vessels in the skin tissue, which have been shown to facilitate or inhibit systemic or skin tissue deposition of drug substances. The level of stimulation and/or inhibition has been found to be dependent on the concentration and the identity of the specific vasodilator chemical(s) used as well as the drug molecule(s) to be delivered. This work teaches the need to consider specific formulation requirements when dealing with vasodilator chemicals for the creation of successful delivery vehicles in the transdermal drug delivery system. These requirements for very low concentrations of vasodilators were an unexpected and a surprise finding, in contrast to the concentrations of the vasodilators typically used to elicit an increase in skin blood flow.

Priority:

Inventor: CARTER STEPHEN [US]; ZHU ZHEN [US]; PATEL KANU [US]

Title: Use of active extracts to improve the appearance of skin, lips, hair and/or nails

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 11/155359   Filing Date: 17/Jun/2005

Abstract:There is provided a composition having at least one of the following active extracts Butea frondosa, Naringi crenulata, Stenoloma chusana, or any combinations thereof. There is also provided a composition having at least one of the following additional extracts Azadirachta indica, Glycyrrhiza glabra linn., Morinda citrifolia, tomato glycolipid or any combinations thereof in combination with one or more of the active extracts. The compositions and methods of the invention are effective to improve the aesthetic appearance of skin, lips, hair and/or nails, especially by lightening the skin, lips, hair and/or nails.

Priority: WO2003US39893 Applic. Date: 2003-12-16; US2002-321706 Applic. Date: 2002-12-17

Inventor: MAHALINGAM HARISH [US]; JONES BRIAN C [US]; MCCAIN NICOLE [US]; LIMTRAKUL PORNNGARM [TH]

Title: Cosmetic composition for caring for or making up keratin materials, comprising at least one polyester, and method of use thereof

Applicant/Assignee:

Application No.: 11/179463   Filing Date: 13/Jul/2005

Abstract:The present disclosure relates to a cosmetic composition, for caring for or making up keratin materials, comprising, in a cosmetically acceptable medium, i) at least one polyester derived from the esterification, with a polycarboxylic acid, of an aliphatic hydroxycarboxylic acid ester comprising at least two hydroxyl groups and ii) at least one volatile oil. The present disclosure also relates to a method of imparting to a cosmetic composition at least one cosmetic property chosen from gloss, staying-power and comfort properties.

Priority: FR20040051514 Applic. Date: 2004-07-13; US20040591625P Applic. Date: 2004-07-28

Inventor: FILIPPI VANINA [FR]

Title: Solid water-in-oil cosmetic emulsion

Applicant/Assignee:

Application No.: 11/182801   Filing Date: 18/Jul/2005

Abstract:Disclosed is a solid water-in-oil emulsion comprising an aqueous phase emulsified with at least one emulsifying surfactant in a fatty phase comprising at least one ester oil and at least one wax, wherein the at least one ester oil is present in an amount greater than the at least one wax and wherein the emulsion has, after at least one month at 37 DEG C., a hardness wherein the penetration force is greater than or equal to 45 g. Also disclosed is a non-therapeutic cosmetic process for making up or caring for the skin, comprising the application to the skin of a composition comprising said emulsion.

Priority: FR20040051549 Applic. Date: 2004-07-16; US20040601989P Applic. Date: 2004-08-17

Inventor: FONTAINE JACQUELINE [FR]; THEMENS AGNES [FR]

Title: Solid water-in-oil cosmetic emulsion

Applicant/Assignee:

Application No.: 11/182849   Filing Date: 18/Jul/2005

Abstract:Disclosed herein is a solid water-in-oil emulsion comprising an aqueous phase emulsified in a fatty phase comprising at least one ester oil and at least one wax, and at least one silicone surfactant comprising at least one polyhydroxylated chain or at least one alkyl dimethicone copolyol chosen from C8-C22 alkyl dimethicone copolyols, as well as a process for making up or caring for skin, comprising applying to the skin the emulsion.

Priority: FR20040051548 Applic. Date: 2004-07-16; FR20040051550 Applic. Date: 2004-07-16; US20040601990P Applic. Date: 2004-08-17; US20040602328P Applic. Date: 2004-08-18

Inventor: THEMENS AGNES [FR]

Title: Cosmetic or pharmaceutical composition comprising peptides with the sequences arggly-ser

Applicant/Assignee: ISP INVESTMENTS INC

Application No.: 10/534355   Filing Date: 09/May/2005

Abstract:The invention relates to the use of at least one peptide, with the sequence (AA)n-Arg-Gly-Ser-(AA)n, where (AA) is any amino acid or a derivative thereof and n=0 to 3, as an active ingredient in or for the preparation of a cosmetic and/or dermatological and/or pharmaceutical preparation. The invention also relates to the use thereof for the treatment, amongst others, of the effects of cutaneous aging and/or the use thereof against cellulite, to a composition comprising the same and to a cosmetic method for the treatment of the skin using said peptide or said composition.

Priority: FR20020014012 Applic. Date: 2002-11-08; FR20030009889 Applic. Date: 2003-08-13; WO2003FR03280 Applic. Date: 2003-11-04

Inventor: DAL FARRA CLAUDE [FR]; DOMLOGE NOUHA [FR]; BOTTO JEAN-MARIE [FR]

Title: Transdermal drug delivery formulations with optimal amounts of vasodilators therein

Applicant/Assignee:

Application No.: 10/893778   Filing Date: 16/Jul/2004

Abstract:Topical drug delivery formulations with optical amounts of vasodilator. Vasodilator chemicals applied topically dilate the blood vessels in the skin tissue, which have been shown to facilitate or inhibit systemic or skin tissue deposition of drug substances. The level of stimulation and/or inhibition has been found to be dependent on the concentration and the identity of the specific vasodilator chemical(s) used as well as the drug molecule(s) to be delivered. This work teaches the need to consider specific formulation requirements when dealing with vasodilator chemicals for the creation of successful delivery vehicles in the transdermal drug delivery system. These requirements for very low concentrations of vasodilators were an unexpected and a surprise finding, in contrast to the concentrations of the vasodilators typically used to elicit an increase in skin blood flow.

Priority:

Inventor: CARTER STEPHEN G [US]; ZHU ZHEN [US]; PATEL KANU [US]

Title: Use of a fibroblast growth factor-binding protein for the treatment and diagnosis of diabetic wound healing problems

Applicant/Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V

Application No.: 10/927322   Filing Date: 26/Aug/2004

Abstract:The present invention relates to the use of fibroblast growth factor-binding protein (FGF-BP) polypeptides, and functional variants of these polypeptides, respectively, or of nucleic acids encoding these polypeptides or variants, or of functional variants of these nucleic acids, and/or of a cell which is expressing an FGF-BP polypeptide or functional variants thereof, for treating, diagnosing and/or preventing wound healing disturbances which are characterized by a reduced quantity of FGF-BP, in particular diabetes-associated wounds, and also to the use of at least one FGF-BP polypeptide as depicted in SEQ ID No. 1 and SEQ ID No. 3 and/or of at least one FGF-BP-encoding nucleic acid as depicted in SEQ ID No. 2 and SEQ ID No. 4 and/or of antibodies or antibody fragments which are directed against an FGF-BP polypeptide which can be used in accordance with the invention, or functional variants thereof, and/or of a cell which is expressing an FGF-BP polypeptide or functional variants thereof, for identifying pharmacologically active substances which increase the activity of expression of FGF-BP.

Priority: EP20020004299 Applic. Date: 2002-02-28; WO2003EP02122 Applic. Date: 2003-02-28; US20020362497P Applic. Date: 2002-03-06

Inventor: GOPPELT ANDREAS [AT]; BITTNER MICHAELA [AT]

Title: Extraction and purification method of active constituents from stem of lonicera japonica thunb., its usage for anti-inflammatory and analgesic drug

Applicant/Assignee: SK CHEMICALS CO., LTD

Application No.: 10/527139   Filing Date: 08/Mar/2005

Abstract:Disclosed is a method for extracting and purifying active constituents from honeysuckle (Lonicera japonica Thunb.) and its use. More particularly, this invention relates to an extraction and purification method of active constituents including sweroside from for honeysuckle stem (stem of honeysuckle where leaves are removed) by removing tannins, hardly soluble flavonoids, saponins, and the like. Thus obtained active constituents have better anti-inflammatory and analgesic effect, are safer and more stable than the conventional active constituents obtained from honeysuckle flower or honeysuckle leaves, and include sweroside which is an effective active ingredient of anti-inflammatory and analgesic drug.

Priority: KR20020055106 Applic. Date: 2002-09-11; KR20020058494 Applic. Date: 2002-09-26; WO2003KR01851 Applic. Date: 2003-09-08

Inventor: KWAK WIE-JONG [KR]; CHO YONG-BAIK [KR]; HAN CHANG-KYUN [KR]; SHIN HEE J [KR]; RYU KEUN H [KR]; YOO HUNSEUNG [KR]; RHEE HAI I [KR]

Title: Cell and tissue engineering utilizing LIF

Applicant/Assignee: L'OREAL

Application No.: 11/137402   Filing Date: 26/May/2005

Abstract:Leukemia Inhibitory Factor ("LIF"), an LIF analogue, an LIF mimetic and a product capable of stimulating the expression of endogenous LIF, and mixtures thereof are useful, for (i) promoting the multiplication, in vitro, of a population of human skin stem cells and/or epidermal progenitors while maintaining them in an undifferentiated state, and/or for (ii) maintaining and/or increasing their capacity to generate a pluristratified epithelium, in particular a pluristratified epidermis and/or all or some of the skin appendages

also a library or a culture of human undifferentiated skin stem cells and/or epidermal progenitors is obtained in the presence of LIF, as are reconstructed epidermides and/or reconstructed skin, and kits for producing libraries of cells or reconstructed epidermides, and stem cells or reconstructed epidermides are prepared for the treatment of individuals exhibiting damaged skin (individuals suffering from third degree burns and individuals suffering from genetic diseases affecting the skin).

Priority: FR20040051037 Applic. Date: 2004-05-26; US20050641435P Applic. Date: 2005-01-06

Inventor: FORTUNEL NICOLAS [FR]; BERNARD DOMINIQUE [FR]; FERRARIS CORINNE [FR]; REGNIER MARCELLE [FR]

Title: Highly pure bases of 3,3-dipheyl propylamine monoesters

Applicant/Assignee: SCHWARZ PHARMA AG

Application No.: 10/532836   Filing Date: 26/Apr/2005

Abstract:The invention relates to a compound of general formula (I) wherein A represents deuterium or hydrogen, R represents a group selected from C1-6 alkyl, C3-10 cycloalkyl or phenyl, which can be substituted by C1-3 alkoxy, fluorine, chlorine, bromine, iodine, nitro, amino, hydroxyl, oxo, mercapto or deuterium. The C atom marked with a * (star) can be present in an (R) configuration, in an (S)-configuration or a mixture thereof. The invention is characterised in that the above-mentioned compounds are free bases with a degree of purity of more than 97 wt %. The invention also relates to a method for the production of highly pure compounds of general formula (I) and to the use thereof in the production of medicaments.

Priority: DE20031015917 Applic. Date: 2003-04-08; WO2004EP03567 Applic. Date: 2004-04-03

Inventor: BREITENBACH ARMIN [DE]; MEESE CLAUS [DE]; WOLFF HANS-MICHAEL [DE]; DREWS ROLAND [DE]

Title: Photoprotective compositions comprising methyltrialkylsilanes containing a cinnamate, cinnamamide, benzalmalonamide or benzalmalonate function

Applicant/Assignee: L'OREAL

Application No.: 11/189975   Filing Date: 27/Jul/2005

Abstract:Unique photoprotective compositions contain novel methyltrialkylsilanes bearing a cinnamate, cinnamamide, benzalmalonamide or benzalmalonate function, useful as sunscreens that are active in the field of UV radiation.

Priority: FR20030000909 Applic. Date: 2003-01-28; WO2003EP15038 Applic. Date: 2003-12-19; US20030450708P Applic. Date: 2003-03-03

Inventor: RICHARD HERVE [FR]

Title: Cosmetic or dermatological preparations of the oil-in-water type

Applicant/Assignee: BEIERSDORF AG

Application No.: 11/191230   Filing Date: 27/Jul/2005

Abstract:The present invention includes cosmetic or dermatological preparations of the oil-in-water type comprising an oil phase having incorporated therein one or more citric esters of the general structural formula in which R<1>, R<2 >and R<3>, independently of one another, are chosen from the group consisting of ethyl, propyl and butyl, and R<4 >is a hydrogen atom or a CH3(CO) group

and a water phase, where the difference in density between the oil phase and the water phase (determinable using a computerized digital density meter of the type DMA 45 from chempro/PA at 25 DEG C.) is not greater than 0.01 g.cm<-3>. The present invention also includes a method for the stabilization of oil-in-water formulations.

Priority: DE20001000210 Applic. Date: 2000-01-05; US2002-190075 Applic. Date: 2002-07-03; WO2000EP12780 Applic. Date: 2000-12-15

Inventor: MULLER ANJA [DE]

Title: Use of a cotton honeydew extract as active ingredient in or for preparing a cosmetic and/or pharmaceutical composition

Applicant/Assignee: SOCIETE D'EXTRACTION DES PRINCIPES ACTIFS S.A

Application No.: 10/537359   Filing Date: 03/Jun/2005

Abstract:The invention concerns the use, as active principle, in or for preparing a composition, of an efficient amount of at least one extract of cotton honeydew, the extract or the composition being designed for care of keratinous substrates. The invention also concerns a cosmetic and/or pharmaceutical composition containing said extract, and a method for cosmetic treatment of the skin using said cotton honeydew extract or the composition containing same.

Priority: FR20020015189 Applic. Date: 2002-12-03; WO2003FR03557 Applic. Date: 2003-12-02

Inventor: DAL FARRA CLAUDE [FR]; DOMLOGE NOUHA [FR]; PEYRONEL DOMINIQUE [FR]

Title: Novel drug delivery system

Applicant/Assignee:

Application No.: 11/134631   Filing Date: 19/May/2005

Abstract:A novel modified release dosage form comprising of a high solubility active ingredient, which utilizes dual retard technique to effectively reduce the quantity of release controlling agents. Present invention can optionally comprise additionally another active ingredient as an immediate release form or modified release form. Present invention also relates to a process for preparing the said formulation.

Priority: IN2002MU00698 Applic. Date: 2002-08-05; IN2002MU00696 Applic. Date: 2002-08-05; IN2003MU00081 Applic. Date: 2003-01-22; US2003-630348 Applic. Date: 2003-07-29

Inventor: VAYA NAVIN [IN]; KARAN RAJESH S [IN]; NADKARNI SUNIL S [IN]; GUPTA VINOD K [IN]

Title: Novel drug delivery system

Applicant/Assignee:

Application No.: 11/134632   Filing Date: 19/May/2005

Abstract:A novel modified release dosage form comprising of a high solubility active ingredient, which utilizes dual retard technique to effectively reduce the quantity of release controlling agents. Present invention can optionally comprise additionally another active ingredient as an immediate release form or modified release form. Present invention also relates to a process for preparing the said formulation.

Priority: IN2002MU00698 Applic. Date: 2002-08-05; IN2002MU00696 Applic. Date: 2002-08-05; IN2003MU00081 Applic. Date: 2003-01-22; US2003-630348 Applic. Date: 2003-07-29

Inventor: VAYA NAVIN [IN]; KARAN RAJESH S [IN]; NADKARNI SUNIL S [IN]; GUPTA VINOD K [IN]

Title: Steroid kit and foamable composition and uses thereof

Applicant/Assignee: FOAMIX LTD

Application No.: 11/114410   Filing Date: 26/Apr/2005

Abstract:A composition and therapeutic kit including an aerosol packaging assembly including a container accommodating a pressurized product and an outlet capable of releasing a foamable composition, including a steroid as a foam. The pressurized product includes a foamable composition including: a container accommodating a pressurized product

and an outlet capable of releasing the pressurized product as a foam

wherein the pressurized product comprises a foamable composition including: i. a steroid

ii. at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, a polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight

iii. a surface-active agent

iv. about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent

v. water

and vi. liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition. The composition further may include a therapeutically active foam adjuvant, selected from the group consisting of a fatty alcohol, a fatty acid, a hydroxyl fatty acid

and mixtures thereof.

Priority: WO2003IB05527 Applic. Date: 2003-10-24; IL20020152486 Applic. Date: 2002-10-25; US2004-911367 Applic. Date: 2004-08-04; US20030492385P Applic. Date: 2003-08-04; US20020429546P Applic. Date: 2002-11-29

Inventor: FRIEDMAN DORON [IL]; BESONOV ALEX [IL]; TAMARKIN DOV [IL]; EINI MEIR [IL]

Title: Compositions containing policosanol and biotin and their pharmaceutical uses

Applicant/Assignee:

Application No.: 10/898889   Filing Date: 26/Jul/2004

Abstract:A composition is provided which contains policosanol and biotin and which may be used for treating, preventing and or reducing metabolic syndrome, hypercholesterolemia and hypoglycemia related diseases, total cholesterol, LDL-cholesterol, LDL/HDL ratio, triglycerides, coronary heart disease (heart attacks and strokes), inflammation, deep-vein thrombosis, immunoregulatory diseases, cardiovascular diseases, obesity, insulin resistance, dyslipidemia, raised blood pressure, fatigue, premenstrual syndrome, anxiety, depression and/or neurodegenerative disorders, and/or raising HDL cholesterol in humans and animals. The method comprises administering policosanol and biotin which together effectively lower blood glucose levels and lower the LDL/HDL cholesterol ratio. Typically, the administered composition includes about 0.1-10:1 parts by weight of policosanol to biotin.

Priority:

Inventor: BERLIN ROGER [US]

Title: Compositions containing policosanol and omega-3 fatty acids and their pharmaceutical uses

Applicant/Assignee:

Application No.: 10/898897   Filing Date: 26/Jul/2004

Abstract:A composition is provided which contains policosanol and omega-3 fatty acids and which may be used for treating and or reducing hypercholesterolemic diseases, total cholesterol, LDL-cholesterol, LDL/HDL ratio, triglycerides, coronary heart disease (heart attacks and strokes), sudden cardiac death, ventricular fibrillation, tachycardia, hypertension, inflammation, thrombosis, deep-vein thrombosis, stroke, macular degeneration, autoimmune and/or immunoregulatory diseases, cardiovascular diseases, anxiety, depression and/or neurodegenerative disorders, and/or raise HDL cholesterol in humans and animals. The method comprises administering policosanol and omega-3 fatty acids which together effectively lower the LDL/HDL cholesterol ratio. Typically, the administered composition includes about 0.1-10:1 parts by weight of policosanol to omega-3 fatty acids.

Priority:

Inventor: BERLIN ROGER [US]

Title: Compositions comprising lycopene for the treatment and prevention of angiogenesis associated pathologies

Applicant/Assignee: DMS IP ASSETS B.V

Application No.: 10/504829   Filing Date: 16/Aug/2004

Abstract:The invention is concerned with the use of lycopene, optionally in combination with vitamin E and/or C or other biologically active ingredients as disclosed in the specification, in the manufacture of a composition for the primary and secondary prevention of angiogenesis-associated pathologies and coadjuvant treatment thereof

as well as with particular novel formulations comprising lycopene.

Priority: EP20020003544 Applic. Date: 2002-02-15; WO2003EP01149 Applic. Date: 2003-02-06

Inventor: GORALCZYK REGINA [CH]; JUNG KLAUS [DE]; LEIN MICHAEL [DE]; BARELLA LUCA [CH]; SILER ULRICH [CH]; STOCKLIN ELISABETH [CH]; WERTZ KARIN [DE]

Title: Nanoparticulate organc uv absorber

Applicant/Assignee:

Application No.: 10/509636   Filing Date: 29/Sep/2004

Abstract:The present invention relates to a UV absorber which comprises a finely divided polymer with a volume-average particle size of from 5 to 1 000 nm, to a process for its preparation, and to its use for stabilizing molding compositions and coating films and as a light protection factor in cosmetic formulations.

Priority: DE20021015752 Applic. Date: 2002-04-10; WO2003EP03692 Applic. Date: 2003-04-09

Inventor: KOENEMANN MARTIN [US]

Title: Foamable compositions containing nitro-imidazoles, processes for preparing same and methods of treatment utilizing same

Applicant/Assignee: AGIS INDUSTRIES (1983) LTD

Application No.: 11/194518   Filing Date: 02/Aug/2005

Abstract:A pharmaceutical or cosmeceutical foamable composition for topical application of nitroimidazoles such as Metronidazole and a process of manufacturing the same is disclosed. A method of treatment of skin and scalp disorders, especially of rosacea, acne and foul smelling lesions, by dispensing nitroimidazoles such as Metronidazole in foamable composition is also disclosed.

Priority: US20040592524P Applic. Date: 2004-08-02

Inventor: ARKIN MOSHE [IL]; UZAN RINA [IL]; BRAGHINSKI BELA [IL]

Title: Water-in-oil emulsion foundation comprising a polyol

Applicant/Assignee:

Application No.: 10/784909   Filing Date: 24/Feb/2004

Abstract:The invention relates to a fluid foundation in the form of water-in-oil emulsion comprising an oil and an aqueous phase comprising a polyol, and optionally polymethyl methacrylate particles, the water+polyol/oil weight ratio being greater than or equal to 0.8. The foundation slides well on the skin and has a sensation of lightness when applied.

Priority: FR20030006150 Applic. Date: 2003-05-22; US20030506774P Applic. Date: 2003-09-30

Inventor: GARDEL NADIA [FR]; BARROIS VERONIQUE [FR]; CHAMPENOIS SANDRINE [FR]

Title: Novel dosage form

Applicant/Assignee:

Application No.: 11/134633   Filing Date: 19/May/2005

Abstract:A dosage form comprising of a high dose, high solubility active ingredient as modified release and a low dose active ingredient as immediate release where the weight ratio of immediate release active ingredient and modified release active ingredient is from 1:10 to 1:15000 and the weight of modified release active ingredient per unit is from 500 mg to 1500 mg

a process for preparing the dosage form.

Priority: IN2002MU00699 Applic. Date: 2002-08-05; IN2002MU00697 Applic. Date: 2002-08-05; IN2003MU00080 Applic. Date: 2003-01-22; IN2003MU00082 Applic. Date: 2003-01-22; US2003-630446 Applic. Date: 2003-07-29

Inventor: VAYA NAVIN [IN]; KARAN RAJESH S [IN]; SADANAND SUNIL [IN]; GUPTA VINOD K [IN]

Title: Compositions containing policosanol and chromium and/or chromium salts and their pharmaceutical uses

Applicant/Assignee:

Application No.: 10/900049   Filing Date: 27/Jul/2004

Abstract:A composition is provided which contains policosanol and chromium and/or chromium salts and which may be used for treating, preventing and or reducing metabolic syndrome, hypercholesterolemia and hypoglycemia related diseases, total cholesterol, LDL-cholesterol, LDL/HDL ratio, triglycerides, coronary heart disease (heart attacks and strokes), inflammation, deep-vein thrombosis, immunoregulatory diseases, cardiovascular diseases, obesity, insulin resistance, dyslipidemia, raised blood pressure, fatigue, premenstrual syndrome, anxiety, depression and/or neurodegenerative disorders, and/or raising HDL cholesterol and/or lean body mass in humans and animals. The method comprises administering policosanol and chromium and/or chromium salts which together effectively lower blood glucose levels and lower the LDL/HDL cholesterol ratio. Typically, the administered composition includes about 0.1-10:1 parts by weight of policosanol to chromium and/or chromium salts.

Priority:

Inventor: BERLIN ROGER [US]

Title: Isoindoline compounds and methods of their use

Applicant/Assignee: CELGENE CORPORATION

Application No.: 10/900332   Filing Date: 28/Jul/2004

Abstract:Novel isoindoline compounds are disclosed. Methods of treating, preventing and/or managing cancer, diseases and disorders associated with, or characterized by, undesired angiogenesis, and diseases and disorders mediated by PDE 4, using the compounds are also disclosed.

Priority:

Inventor: MULLER GEORGE W [US]; MAN HON-WAH [US]

Title: Compositions containing policosanol and B vitamins and their pharmaceutical uses

Applicant/Assignee:

Application No.: 10/900040   Filing Date: 27/Jul/2004

Abstract:A composition is provided which contains policosanol and B vitamins and which may be used for treating and or reducing hypercholesterolemia and hyperhomocysteinemia diseases, total cholesterol, LDL-cholesterol, LDL/HDL ratio, Lp(a), triglycerides, homocysteine, coronary heart disease (heart attacks and strokes), carotid artery disease, inflammation, deep-vein thrombosis, immunoregulatory diseases, cardiovascular diseases, anxiety, depression, neurodegenerative disorders (such as but not limited to Alzheimers), and/or raise HDL cholesterol in humans and animals. The method comprises administering policosanol and B vitamins which together effectively lower the risk of heart disease. Typically, the administered composition includes about 0.1-10:1 parts by weight of policosanol to B vitamins.

Priority:

Inventor: BERLIN ROGER [US]

Title: Vision thermalization for sightless & visually impaired

Applicant/Assignee:

Application No.: 10/914257   Filing Date: 09/Aug/2004

Abstract:A Vision Thermalization, "VT" light-to-heat transducer, versatile video transformation system, via Biophysics Resonance of forehead cells with thin film transistors infrared "display" (1kx0.0015Cx640x480 VGA) and alternative image processing methodology thereof to convert, for the sightless and visually impaired, light waves, or TV received signals or 2D/3D video camera signals into infrared patterns of sensible heat waves such as produced by the product of voltage and current in an active matrix of thin film transistors (AM-TFT), typically used with liquid crystal displays, in order to exploit the viper-like thermal vision sensibility of 10 parts/million (0.003C/305K) and biophysics resonance of thermo regulating amino acids.

Priority:

Inventor: STAPLETON JOHN J [US]

Title: Aqueous-alcoholic depigmenting gels

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT, S.N.C

Application No.: 11/150176   Filing Date: 13/Jun/2005

Abstract:Topically applicable, stable and non-irritating aqueous-alcoholic cosmetic/dermatological gels suited for cutaneous depigmentation contain water, at least one alcohol, at least one gelling agent, at least one phenolic compound, at least one retinoid, and, optionally, at least one sunscreen, formulated into a topically applicable, physiologically acceptable medium therefor.

Priority: FR20020015750 Applic. Date: 2002-12-12; WO2003EP15021 Applic. Date: 2003-12-03; US20020434433P Applic. Date: 2002-12-19

Inventor: LOUIS FABIENNE [FR]; ORSONI SANDRINE [FR]; FREDON LAURENT [FR]

Title: Cutanceous metabolic bio-activator

Applicant/Assignee: JEAN-NOEL THOREL

Application No.: 10/537816   Filing Date: 07/Jun/2005

Abstract:The invention relates to a cosmetic composition comprising a bio-active system which combines (i) a stable form in aqueous solution of ATP (adenosine-tri-phosphate) with optionally an ATP precursor, e.g. Gp4G (diguanosine tetraphosphate), or Ap4A (diadenosine tetraphosphate), and (ii) at least one biomimetic peptide comprising at most six amino acids, mimicking a cutaneous polypeptide or a cutaneous protein, or a biomolecule which is agonist or antagonist in relation to the aforementioned polypeptide or protein. According to the invention, the composition takes the form of a water-in-oil or oil-in-water emulsion, the bio-active system being included in the aqueous phase.

Priority: FR20020016871 Applic. Date: 2002-12-30; FR20020016872 Applic. Date: 2002-12-30; FR20020016873 Applic. Date: 2002-12-30; FR20020016874 Applic. Date: 2002-12-30; WO2003FR03883 Applic. Date: 2003-12-23

Inventor: THOREL JEAN-NOEL [FR]; REDZINIAK GERARD [FR]

Title: Invert emulsions comprising at least one active agent sensitive to water and cosmetic/dermatological applications thereof

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT, S.N.C

Application No.: 11/196301   Filing Date: 04/Aug/2005

Abstract:Cosmetic/dermatological compositions useful for the treatment of a variety of dermatological conditions, including keratinization disorders, acne, eczema, psoriasis, etc., comprise an invert emulsion containing at least one active agent sensitive to the presence of water, notably a derivative of vitamin D, and solubilized in a glycolic or hydroglycolic dispersed hydrophilic phase, a lipophilic continuous phase and an emulsifier having an HLB ranging from 2 to 7

these invert emulsions exhibit good stability and avoid crystallization of the active agent and/or chemical degradation thereof.

Priority: FR20030001349 Applic. Date: 2003-02-05; WO2004EP04526 Applic. Date: 2004-02-03; US20030452940P Applic. Date: 2003-03-10

Inventor: ASTRUC FANNY [FR]; ORSONI SANDRINE [FR]; BRZOKEWICZ ALAIN [FR]

Title: Low-residue deodorant or antiperspirant stick based on an oil-in-water dispersion

Applicant/Assignee:

Application No.: 11/192389   Filing Date: 28/Jul/2005

Abstract:Deodorant or antiperspirant sticks based on an oil-in-water dispersion for application to the skin.

Priority: DE200410036689 Applic. Date: 2004-07-28

Inventor: BANOWSKI BERNHARD [DE]; WADLE ARMIN [DE]; CLASS MARCUS [DE]

Title: Analgesic patch for sports injury rehabilitation medicine and method to alleviate pain

Applicant/Assignee:

Application No.: 11/196964   Filing Date: 04/Aug/2005

Abstract:The present invention relates to a method for topical treatment of pain resulting from a sports injury, including injuries to bones and soft tissue, such as ligaments, muscles or tendons. The method includes the steps of: applying to skin of a subject suffering from pain resulting from a sports injury a transdermal drug delivery system comprising a formulation comprising a pain-relieving amount of a local anesthetic and a pharmaceutically acceptable carrier, wherein the transdermal drug delivery system is applied to a skin site proximate to or in the region of a sports injury, and relieving the pain. The concentrated local anesthetic in the patch penetrates deeply below the skin to the injury site to inhibit pain receptors throughout the damaged body tissue.

Priority: US20040598694P Applic. Date: 2004-08-04

Inventor: CASSEL R D [US]

Title: Topical skin protectant compositions

Applicant/Assignee: STIEFEL LABORATORIES, INC

Application No.: 11/089030   Filing Date: 25/Mar/2005

Abstract:Skin protectant compositions that are free of cholesterol and suitable for topical application to skin of a mammal. In a preferred embodiment, these skin protectant compositions comprise a ceramide

a squalane

a phytosterol-containing liposome

a phospholipid-containing ingredient

at least one triglyceride

and at least one dermatologically acceptable excipient. These compositions are capable of restoring or repairing a skin lipid barrier of a mammal, and treating skin conditions associated therewith.

Priority: US20040556428P Applic. Date: 2004-03-26

Inventor: POPP KARL F [US]; WAGNER JOHN A [US]

Title: Transdermal administration of (r)-3,3-diphenylpropylamin-monoesters

Applicant/Assignee: SCHWARZ PHARMA AG

Application No.: 10/533683   Filing Date: 26/Apr/2005

Abstract:The invention relates to a device for transdermally administering a compound of formula (I), wherein A represents hydrogen or deuterium, R represents a group selected among C1-4alkyl, C3-10cycloalkyl, or phenyl, each of which can be substituted by C1-3 alkoxy, fluoride, chlorine, bromine, iodine, nitro, amino, hydroxy, oxo, mercapto, or deuterium, the C atom marked by * (asterisk) being provided in the R configuration. The invention is characterized in that the compound of general formula (I) is provided in a polymer matrix and is released at a dose of 0.5 to 20 mg per day through human skin. The invention further relates to the use of said compounds of formula (I) for producing transdermal medicaments.

Priority: DE20031015878 Applic. Date: 2003-04-08; WO2004EP03574 Applic. Date: 2004-04-03

Inventor: BREITENBACH ARMIN [DE]; MEESE CLAUS [DE]; WOLFF HANS-MICHAEL [DE]; DREWS ROLAND [DE]

Title: Appendix of 2.7% (approx.) 9% saline, 56% saline

Applicant/Assignee:

Application No.: 11/017708   Filing Date: 05/Sep/2005

Abstract:The name of invention is Saline and the Saline is NaCl sol. is distinguished by density. In this invention solution, Pus at wound can be removed without curettage and antibiotics by lysis of phosphatide of H+. In 2.7% (approx.) 9% Saline sol. of in potential power of semipermeable memb., Membrane formation and cell mutiplication become by electric passive transport of H+. In this sol. cell culture is possible. In 56%(9% (approx.) 56%) Saline sol. out of potential power of semipermeable memb. thick memb. be made, and the thick memb. can substituted for skin. Unnecessary cell can be removed without operation by memb. disfunction of Osmosis. And Transformation of tissue can be repaired by absorption press.

Priority: KR20040031376U Applic. Date: 2004-02-25

Inventor: KIM ARAN [KR]

Title: Skin protection composition

Applicant/Assignee: HOUOUDOU CO., LTD

Application No.: 11/246194   Filing Date: 11/Oct/2005

Abstract:The present invention provides: a skin protection composition that can effectively suppress intrusion of contagious bacteria such as Pseudomonas aeruginosa, Bacillus subtilis, Bacillus anthracis, Escherichia coli, Staphylococcus aureus, or MRSA, and viruses such as influenza virus from wounds, skin and mucosa such as those of the eyes, nose, throat, ears, anus and vagina into the body, and can also suppress growth of the bacteria and viruses

a skin protection composition that can effectively prevent hospital infections or the like caused by resistant bacteria

a composition to prevent and/or treat bacterial and viral infections including hospital infections

an antiseptic

and a filter apparatus that can effectively suppress intrusion into the body and growth therein of contagious bacteria and viruses. The skin protection composition

skin protection composition that can effectively prevent hospital infections or the like caused by resistant bacteria

composition to prevent and/or treat bacterial and viral infections including hospital infections

antiseptic

and filter apparatus that can effectively suppress intrusion into the body of contagious bacteria and viruses characterized by comprising Sasa extract, or Sasa extract and an organic acid as the active component.

Priority: WO2003JP04635 Applic. Date: 2003-04-11

Inventor: TSUCHIDA YUUZOU [JP]; TSUCHIDA KOTAROU [JP]; TSUCHIDA KENJIROU [JP]; WATANABE KUNITOMO [JP]; NAKAMURA YOSHIKO [JP]; IWASAWA ATSUO [JP]

Title: Detergent composition with benefit agents

Applicant/Assignee: CONOPCO, INC., D/B/A UNILEVER CONOPCO, INC

Application No.: 11/197186   Filing Date: 04/Aug/2005

Abstract:A rinse off liquid or gel cleansing composition comprising a continuous phase comprising one or more detergent actives and a dispersed phase comprising one or more hydrophobic materials, the dispersed phase comprising a water soluble or dispersible benefit agent which is sensitive to a detergent active and/or high pH, which benefit agent is dispersed in the hydrophobic material.

Priority: IN2004MU00830 Applic. Date: 2004-08-04

Inventor: DABHOLKAR NANDINI S [IN]; KRISHNAN VENKARESWARAN [IN]; SHAH PANKAJ C [IN]; SIVAKUMAR ANANTHASUBRAMANIAN [IN]

Title: Foamable compositions containing vitamin D3 analogues, processes for preparing same and methods of treatment utilizng same

Applicant/Assignee: AGIS INDUSTRIES (1983) LTD

Application No.: 11/194521   Filing Date: 02/Aug/2005

Abstract:A pharmaceutical or cosmeceutical foamable composition for topical application of vitamin D3 analogues such as calcipotriene and a process of manufacturing the same is disclosed. A method of treatment of skin and scalp disorders, especially of psoriasis or ear infections, by dispensing vitamin D3 analogues such as calcipotriene in a foamable composition is also disclosed.

Priority: US20040592380P Applic. Date: 2004-08-02

Inventor: ARKIN MOSHE [IL]; ZEEVI AMIRA [IL]

Title: Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages

Applicant/Assignee: L'OREAL

Application No.: 11/202192   Filing Date: 12/Aug/2005

Abstract:Inhibitors of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), for example tetrazole, styrylpyrazole, phenylfuran, phenylthiophene, phenylpyrrazole, pyrazolecarboxamide, 2-thioacetamide and azo compounds, are useful for promoting or stimulating pigmentation of the skin and/or skin appendages and/or for preventing and/or for limiting depigmentation and/or whitening of the skin and/or skin appendages, notably for preventing and/or limiting canities.

Priority: FR20030050023 Applic. Date: 2003-02-12; WO2004FR00325 Applic. Date: 2004-02-12; US20030456563P Applic. Date: 2003-03-24

Inventor: MICHELET JEAN-FRANCOIS [FR]; COMMO STEPHANE [FR]

Title: Microprojection apparatus and system with low infection potential

Applicant/Assignee:

Application No.: 11/201617   Filing Date: 10/Aug/2005

Abstract:A transdermal agent delivery apparatus and system having a low infection potential comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the microprojection member includes a biocompatible coating having at least one biologically active agent and at least one antimicrobial agent disposed therein. In another embodiment, the microprojection member includes a hydrogel formulation having at least one biologically active agent and at least one antimicrobial agent. In yet another embodiment, the microprojection member includes a hydrogel formulation having at least one antimicrobial agent and a solid film having at least one biologically active agent.

Priority: US20040600638P Applic. Date: 2004-08-10

Inventor: CORMIER MICHEL J [US]; DADDONA PETER [US]; ANDERSON ROLFE [US]

Title: Apparatus and method for transdermal delivery of natriuretic peptides

Applicant/Assignee:

Application No.: 11/201625   Filing Date: 10/Aug/2005

Abstract:An apparatus and method for transdermally delivering a natriuretic peptide comprising a delivery system having a microprojection member that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the natriuretic peptide is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a natriuretic peptide-containing hydrogel formulation. In an alternative embodiment, the natriuretic peptide is contained in both the coating and the hydrogel formulation. In yet another embodiment, the natriuretic peptide is contained in a solid state formulation.

Priority: US20040600560P Applic. Date: 2004-08-11

Inventor: MAA YUH-FUN [US]; SELLERS SCOTT [US]; DADDONA PETER [US]; KAMBERI MARIKA [US]; GOPALAKRISHNAN VIDHYA [US]; SILBER B M [US]; STONEBANKS FRANK [US]

Title: Transdermal delivery using emcapsulated agent activated by ultrasound and or heat

Applicant/Assignee: ULTRA-SONIC TECHNOLOGIES, L.L.C

Application No.: 10/541001   Filing Date: 28/Jun/2005

Abstract:A method for delivery of substance through at least one dermal layer, by providing a substance in microcapsules at a predetermined size, within a medium ( 150 ) for holding the microcapsules

placing the medium for holding the microcapsules on a surface of a patch ( 100 ) adjacent the skin ( 320 ) of a human or animal

and applying energy ( 200 ) to the patch, the energy having a characteristic of disturbing the integrity of the microcapsules, thereby resulting in release of the substance from the microcapsules. The energy may be selectively applied to release the substance at desired times. The substance may be a drug or other active agent.

Priority: US20020437541P Applic. Date: 2002-12-31; WO2003US41850 Applic. Date: 2003-12-31

Inventor: WEIMANN LUDWIG J [US]

Title: Adhesive composition

Applicant/Assignee:

Application No.: 11/198468   Filing Date: 04/Aug/2005

Abstract:An adhesive composition is described which has improved initial tack, long-term adhesion, water uptake and translucency characteristics and may be prepared by melt extrusion. Uses of these compositions are also described, for example, their use as blister pads and wound dressings.

Priority: US20040599593P Applic. Date: 2004-08-05

Inventor: SINGH PARMINDER [US]; CLEARY GARY W [US]; KULICHIKHIN VALERY G [RU]; ANTONOV SERGEY [RU]

Title: Agent for inhibiting the growth of mammalian hair

Applicant/Assignee:

Application No.: 10/988804   Filing Date: 15/Nov/2004

Abstract:The present invention comprises of a composition for post-hair-removal topical application for inhibiting mammalian hair growth & application thereof. The present invention also embraces a method of inhibiting mammalian hair growth by applying an effective amount of the composition to the skin. The composition comprises of a hair growth-inhibiting agent and a dermatologically acceptable vehicle.

Priority: IN2004MU00873 Applic. Date: 2004-08-13

Inventor: KONDHALKAR MRINMAYEE B [IN]

Title: Stem cell libraries

Applicant/Assignee:

Application No.: 11/003840   Filing Date: 06/Dec/2004

Abstract:A stem cell library is created by genetically modifying stem cells with nucleic acids encoding polypeptides which can promote stem cell differentiation into specific cell types. Alternatively, the stem cell library is exposed to an externally added factor that promotes stem cell differentiation into a desired cell line, e.g., neuronal or muscle. The library is used to determine the effect of the encoded protein on the differentiation process. The library is also used to produce nucleic acids for insertion into embryonic stem cells to produce transfected embryonic stem cells. The nucleic acids are inserted into a locus that permits widespread expression of the encoded polypeptide in animals produced from blastocysts that incorporate the transfected cells. Non-human chimeric animals produced by combining blastocysts derived from animal models of human disease and embryonic stem cells transfected with molecules from the library provide an in vivo system for therapeutic design.

Priority: WO2003US34811 Applic. Date: 2003-10-31; US20020423041P Applic. Date: 2002-11-01; US20030454576P Applic. Date: 2003-03-13

Inventor: ZHANG HONGBING [US]; WILLIAMS LEWIS T [US]; CHU KETING [US]; COHEN FRED [US]

Title: Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders

Applicant/Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Application No.: 11/189643   Filing Date: 26/Jul/2005

Abstract:The present invention relates to novel pharmaceutical compositions comprising at least one EGFR kinase inhibitor and at least one additional active compound selected from beta-2 mimetics, steroids, PDE-IV inhibitors, p38 MAP kinase inhibitors, NK1 antagonists and endothelin-antagonists, processes for preparing the compositions and the use thereof as medicament in the treatment of respiratory or gastrointestinal complaints, as well as inflammatory diseases of the joints, the skin or the eyes.

Priority: EP20040018808 Applic. Date: 2004-08-07

Inventor: JUNG BIRGIT [DE]; HIMMELSBACH FRANK [DE]

Title: Carbonylamino-benzimidazole derivatives as androgen receptor modulators

Applicant/Assignee: MERCK & CO., INC

Application No.: 10/533259   Filing Date: 29/Apr/2005

Abstract:Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and/or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, arthritic condition and joint repair,

HIV-wasting, prostate cancer, cancer cachexia, Alzheimer s disease, muscular dystrophies, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Priority: US20020422914P Applic. Date: 2002-11-01; WO2003US34345 Applic. Date: 2003-10-28

Inventor: KIM YUNTAE [US]; HANNEY BARBARA [US]; DUGGAN MARK E [US]; SPENCER KEITH L [US]

Title: Absorbent articles comprising a bodily exudate modifying agent and a skin care formulation

Applicant/Assignee: KIMBERLY-CLARK WORLDWIDE, INC

Application No.: 10/915642   Filing Date: 10/Aug/2004

Abstract:Absorbent articles having enhanced absorption of bodily exudates are disclosed. The absorbent articles comprise a bodily exudate modifying agent and a skin care formulation. The bodily exudate modifying agent is capable of reducing the viscosity of bodily exudates such as feces and menses. The skin care formulation comprises a bodily exudate modifying agent neutralizer to neutralize the possible negative effects on skin barrier function caused by the bodily exudate modifying agents coming into direct contact with the wearer's skin.

Priority:

Inventor: COHEN JASON C [US]; KOENIG DAVID W [US]; BROCK EARL D [US]; BARATIAN STEPHEN A [US]; CUNNINGHAM COREY [US]; BALDWIN STEPHEN [US]

Title: Absorbent articles comprising a bodily exudate modifying agent and a film-forming skin care formulation

Applicant/Assignee: KIMBERLY-CLARK WORLDWIDE, INC

Application No.: 10/915721   Filing Date: 10/Aug/2004

Abstract:Absorbent articles having enhanced absorption of bodily exudates are disclosed. The absorbent articles comprise a bodily exudate modifying agent and a skin care formulation. The bodily exudate modifying agent is capable of reducing the viscosity of bodily exudates such as feces and menses. The skin care formulation comprises a film forming agent that, upon transfer to the skin, can form a continuous film layer on the skin to retard harmful agents.

Priority:

Inventor: BALDWIN STEPHEN [US]; CUNNINGHAM COREY [US]; COHEN JASON C [US]; KOENIG DAVID W [US]; BROCK EARL D [US]; BARATIAN STEPHEN A [US]

Title: COMPOSITIONS COMPRISING AT LEAST ONE ORGANIC POLYMER AND A MIXTURE OF VOLATILE AND NONVOLATILE SOLVENTS

Applicant/Assignee: L'OREAL S.A

Application No.: 10/621534   Filing Date: 17/Jul/2003

Abstract:Abstract of the Disclosure Compositions, for example cosmetic compositions, comprising at least one organic polymer, such as a crosslinked organosoluble polymer, and a mixture of at least two solvents, one of which is volatile and incompatible with the polymer, and the other of which is nonvolatile and compatible with the polymer. These compositions make it possible to form on keratin materials a deposit whose volume increases over time, without the intervention of an external stimulus. These compositions can be, for example, mascaras, lipsticks or anti-wrinkIe formulas in the form of a cream or a foundation. The cosmetic treatment processes using these compositions.

Priority: US2003-621534 Applic. Date: 2003-07-17; FR19990009265 Applic. Date: 1999-07-16; US2000-618031 Applic. Date: 2000-07-17

Inventor: FERRARI VERONIQUE [FR]; TOURNILHAC FLORENCE [FR]

Title: Method of skin care and/or treatment using rice (Oryza sativa) hemoglobin or other hexacoordinated, non-symbiotic plant hemoglobins

Applicant/Assignee:

Application No.: 11/190605   Filing Date: 27/Jul/2005

Abstract:Methods for the prevention and treatment of skin damage arising from exposure to nitric oxide and other pollutant oxidizing species, using rice (Oriza sativa) hemoglobin or other plant hexacoordinated, non-symbiotic hemoglobins, in a dermatologically acceptable carrier that can be topically applied to the skin areas, including lips. In some embodiments, other proteins such as superoxide dismutase and/or catalase or antioxidants are included.

Priority: US20040591340P Applic. Date: 2004-07-27

Inventor: SIVAK HANNAH N [US]; IGLESIAS ALBERTO A [AR]; BALLICORA MIGUEL A [US]

Title: Stable cream preparations of phenyl-pyridone compounds for topical application

Applicant/Assignee: MEPHA AG

Application No.: 10/527555   Filing Date: 11/Mar/2005

Abstract:The invention relates to a pharmaceutical cream preparation for topical application in the form of an oil-in-water (o/w) emulsion, containing the following constituents in the lipophilic phase: (i) an optionally substituted 1-phenyl-2-(1H)-pyridone compound or a pharmaceutically acceptable salt thereof, as an active ingredient, (ii) at least one surface-active solubilising agent having an HLB value between 15 and 20, (iii) at least one emulsifier having an HLB value between 8 and 15, and (iv) optionally other carrier materials and additives known per se selected from the group containing triglycerides, penetration amplifiers, preserving agents and anti-oxidants. The invention also relates to the use of the preparation as a topical cream preparation for the treatment or prophylaxis of skin diseases.

Priority: CH20020001556 Applic. Date: 2002-09-13; WO2003CH00615 Applic. Date: 2003-09-11

Inventor: SCHEIWE MAX W [DE]; CENTIKAYA YALCIN [CH]

Title: Emulsification system for use in cosmetics

Applicant/Assignee: L'OREAL

Application No.: 10/920615   Filing Date: 18/Aug/2004

Abstract:Disclosed are cosmetic compositions containing water, at least one non-polar and/or polar oil, and an emulsification system comprising a polyoxyethylene oxide C12-C24 fatty acid ester

a sucrose fatty acid ester of vegetable origin, and a glyceryl and/or sorbitan C12-C24 fatty acid ester, and methods of making and using the compositions.

Priority:

Inventor: FARES HANI [US]; GROSSO RITA M [US]; FOLTIS SIDNEY PETER [US]; HANSENNE ISABELLE [US]

Title: Cosmetic method of caring for greasy skin

Applicant/Assignee: L'OREAL

Application No.: 11/204158   Filing Date: 16/Aug/2005

Abstract:The present invention relates to a cosmetic method of caring for greasy skin by topical application to the skin of a composition containing, in a physiologically acceptable medium suitable for topical application to the skin and containing an aqueous phase: (a) porous particles having an average diameter by volume of less than or equal to 10 mum and containing at least one active intended for the treatment of greasy skin and (b) particles of at least one sebum-absorbing and/or sebum-adsorbing compound having a number-average particle size of more than 10 mum.

Priority: FR20040008937 Applic. Date: 2004-08-17; US20040606128P Applic. Date: 2004-09-01

Inventor: JOSSE DELPHINE [FR]

Title: Associative thickeners for aqueous systems

Applicant/Assignee: LUBRIZOL ADVANCED MATERIALS, INC

Application No.: 11/206393   Filing Date: 18/Aug/2005

Abstract:Thiocarbonate compounds which, in one embodiment, are utilized as a rheology modifier or associative thickener. The thiocarbonate compounds thicken or increase the viscosity of a composition, preferably an aqueous composition when used in an effective amount. In one preferred embodiment, the thiocarbonate compounds include at least one hydrophilic group containing repeat unit such as derived from acrylic acid, and at least one hydrophobic group to enhance association with other compounds and thus increase viscosity of a composition. Aqueous composition comprising a latex and thiocarbonate associative thickeners are described.

Priority: US20040603448P Applic. Date: 2004-08-20

Inventor: LAI JOHN T [US]; HSU SHUI-JEN R [US]; TAMARESELVY KRISHNAN [US]

Title: Percutaneous absorption accelerator

Applicant/Assignee:

Application No.: 11/137883   Filing Date: 26/May/2005

Abstract:The present invention has as an object to provide a composition for external use on skin whose percutaneous absorption of an active component is increased, whereby a large amount of the active component can be delivered into the skin. By employing diglycerol and a low molecular weight betaine together, a percutaneous absorption accelerator excellent in permeability of an active component is provided. According to the percutaneous absorption accelerator of the present invention, the accelerated percutaneous absorption amount of an active component is greatly increased, whereby an effect which the active component essentially possesses is sufficiently exhibited.

Priority: JP20040160158 Applic. Date: 2004-05-28; CA20052508096 Applic. Date: 2005-05-20

Inventor: INAOKA SATOSHI [JP]; TSUNETSUGU SHUICHI [JP]

Title: Effervescent composition including a grape-derived component

Applicant/Assignee:

Application No.: 10/922075   Filing Date: 19/Aug/2004

Abstract:The invention features an effervescent composition that includes at least one grape-derived component, at least one effervescent agent, and optionally at least one active agent, where the sum of the weight of the grape-derived component and the weight of the active agent constitute at least about 10% by weight of the composition, with the weight of the grape-derived component being greater than weight of the active agent.

Priority:

Inventor: ALDRITT MARY [US]; LEE ROBERT E [US]; WEHLING FRED [US]

Title: Self-forming phospholipidic gels

Applicant/Assignee:

Application No.: 10/534746   Filing Date: 12/May/2005

Abstract:A phospholipid gel is spontaneously formed when combining a first phospholipid, a second phospholipid, and water, wherein the first phospholipid is a neutral phospholipid and the second phospholipid is a negatively charged phospholipid. The first and second phospholipids are of natural origin, semi-synthetic origin, or synthetic origin. Preferably, they are di(C8-C22 acyl) phosphatidyl choline and di(C8-C22 acyl) phosphatidyl glycerol. The total phospholipid concentration is within a range of 6-40% by weight.

Priority: DE20021055285 Applic. Date: 2002-11-26; WO2003DE03883 Applic. Date: 2003-11-24

Inventor: DIEDERICHS JULIA E [DE]

Title: Stabilized body care products, household products, textiles and fabrics

Applicant/Assignee: CIBA SPECIALTY CHEMICALS CORPORATION

Application No.: 11/201377   Filing Date: 10/Aug/2005

Abstract:Disclosed are stabilized body care products, household products, textiles and fabrics which comprise certain sterically hindered amine salt compounds. Dyed products and articles are effectively stabilized against color degradation. The products are for example skin-care products, hair-care products, dentifrices, cosmetics, laundry detergents and fabric softeners, non-detergent based fabric care products, household cleaners and textile-care products.

Priority: US20040603590P Applic. Date: 2004-08-23

Inventor: LUPIA JOSEPH A [CH]; SUHADOLNIK JOSEPH [US]; WOOD MERVIN G [US]; MARTIN WANDA H [US]

Title: Medicaments containing bisphosphonic acids and derivatives thereof for preventing and treating diseases and allergies

Applicant/Assignee:

Application No.: 11/121044   Filing Date: 04/May/2005

Abstract:Provided are compounds and methods for the prevention and treatment of autoimmune disorders and of allergies using such compositions in which autoantigens or allergens previously used for treating autoimmune disorders and allergies are used in combination with bisphosphonates or the derivatives thereof. Bisphosphonic acids and derivatives thereof generally corresponding to Formula I illustrated below are useful in the production of pharmaceutical formulations that may be used for the prevention and treatment of various autoimmune diseases or allergies. The bisphosphonic acids and the derivatives thereof which are used are those represented by the Formula I: in which the variables A1, A2, A3, A4, R1, R2 and X are selected from a range of substituents as outlined in the specification.

Priority: US2000-719946 Applic. Date: 2000-12-15

Inventor: JOMAA HASSAN [DE]

Title: Meso-substituted porphyrins

Applicant/Assignee: L. MOLTENI & C. DEI FRATELLI ALITTI SOCIETA DI ESERCIZIO S.P.A

Application No.: 10/532278   Filing Date: 21/Apr/2005

Abstract:Meso-substituted porphyrins of general formula (I) suitable for the use as photosensitising agents, in particular in photodynamnic therapy, are herein described.

Priority: IT2002FI00200 Applic. Date: 2002-10-21; WO2003EP11642 Applic. Date: 2003-10-21

Inventor: RONCUCCI GABRIO [IT]; DEI DONATA [IT]; GIUNTINI FRANCESCA [IT]; CHITI GIACOMO [IT]; NISTRI DANIELE [IT]; FANTETTI LIA [IT]; PASCHETTA VALENTINA [IT]; COCCHI ANNALISA [IT]

Title: Fused ring NK1 antagonists

Applicant/Assignee: SCHERING CORPORATION

Application No.: 11/100226   Filing Date: 06/Apr/2005

Abstract:A compound having the general structure shown in Formula 1: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.

Priority: US20040560343P Applic. Date: 2004-04-07

Inventor: XIAO DONG [US]; PALANI ANANDAN [US]; WANG CHENG [US]; TSUI HON-CHUNG [US]; SHIH NENG-YANG [US]; REICHARD GREGORY A [US]

Title: Composition and method for the treatment of psoriasis

Applicant/Assignee:

Application No.: 11/204491   Filing Date: 16/Aug/2005

Abstract:The use of a prostaglandin A2 derivative, and prodrugs of the compound, for the manufacture of a medicament for the treatment and/or alleviation of psoriasis is presented, as well as a method of treatment, involving the topical application of such prostaglandins. Compositions containing a therapeutically active, and physiologically acceptable amount of the above compound or derivatives thereof, as such or in the form of a prodrug, in a suitable vehicle are also described. Importantly, the derivatives can be applied in therapeutically active amounts without or with only minimal side effects, such as hyperemia, irritation or pain.

Priority: SE20040002029 Applic. Date: 2004-08-17

Inventor: STJERNSCHANTZ JOHAN [FI]; RESUL BAHRAM [SE]

Title: Pharmaceutical compositions delivery system and methods

Applicant/Assignee:

Application No.: 10/923937   Filing Date: 23/Aug/2004

Abstract:A method, system and applicator for the solvent-less delivery of a bio-active material to a receiver. The applicator includes a discharge device, a reservoir which holds a bioactive material, and a solvent at a supercritical fluid state for delivering the bioactive material through the discharge device to the receiver. A spacer may be positioned between the discharge device and the receiver. The receiver may have a plurality of different bio-active material to be applied to a subject, each located at a different location on the receiver.

Priority:

Inventor: PATTON DAVID L [US]; SPOONHOWER JOHN P [US]; NELSON DAVID J [US]; POCHAN JOHN M [US]; KEEFE TIMOTHY [US]; REED KENNETH J [US]; MEHTA RAJESH V [US]; JAGANNATHAN RAMESH [US]

Title: Sunless tanning composition and methods for using

Applicant/Assignee:

Application No.: 10/933128   Filing Date: 02/Sep/2004

Abstract:A sunless tanning composition is provided according to the invention. The sunless tanning composition includes a polymer component, a tanning active component, water, and the composition is provided as an emulsion and has a viscosity of less than about 25 cSt. A method for using a sunless tanning composition is provided.

Priority:

Inventor: ROSZELL JAMES A [US]

Title: Composition and method for reducing harmful effects of ultraviolet radiation impinging on the skin

Applicant/Assignee:

Application No.: 11/211191   Filing Date: 25/Aug/2005

Abstract:A composition is provided that is suitable for topical administration for the treatment of skin to reduce the harmful effects of ultraviolet radiation impinging on the skin, the composition comprising acetylsalicylic acid and sodium bicarbonate. Also provided is a method for treating skin to reduce the harmful effects of ultraviolet radiation impinging on the skin comprising topically administering to the skin a therapeutically effective amount of a composition comprising acetylsalicylic acid and sodium bicarbonate. Also provided is an aqueous composition suitable as an additive to a composition of cosmetics comprising acetylsalicylic acid and sodium bicarbonate. Also provided is a method of manufacturing a cosmetic composition, comprising obtaining an aqueous composition that includes acetylsalicylic acid and sodium bicarbonate, and combining the aqueous composition with cosmetic ingredients to create the cosmetic composition.

Priority: US20040604888P Applic. Date: 2004-08-26

Inventor: FULLER PETER E [US]

Title: S-triazine sunscreens bearing hindered para-aminobenzalmalonate/para-aminobenzalmalonamide and aminobenzoate/aminobenzamide substituents

Applicant/Assignee:

Application No.: 11/214865   Filing Date: 31/Aug/2005

Abstract:Novel s-triazine sunscreens have the structural formula (I): and are formulated into cosmetic/dermatological photoprotective compositions useful for photoprotecting keratinous substances against the damaging effects of UV-radiation.

Priority: FR20040009292 Applic. Date: 2004-09-02; US20040614210P Applic. Date: 2004-09-30

Inventor: RICHARD HERVE [FR]; LEJUSTE CATHERINE [FR]

Title: Reduced odor in low molecular weight cationic polygalactomannan

Applicant/Assignee:

Application No.: 11/202469   Filing Date: 12/Aug/2005

Abstract:A reduced odor composition is composed of at least one cationic polygalactomannan or a derivative of cationic polygalactomannan having a weight average molecular weight (Mw) having a lower limit of 5,000 and an upper limit of 200,000, a light transmittance in a 10% aqueous solution of greater than 80% at a light wavelength of 600 nm, a protein content of less than 1.0% by weight of polysaccharide, and a trimethylamine content of less than 25 ppm in a 10% aqueous solution of the polymer. This composition is prepared by treating the polymer with reagents that reduce the molecular weight of the polymer, removing the water-insoluble solid material, and removing odorous components, including trimethylamine (TMA) and other amines and low molecular weight components from the aqueous phase to produce a polymer that when used in a functional system such as household care, personal care or pet care products has reduced or no odor at acidic, neutral, or alkaline pH values.

Priority: US20040605556P Applic. Date: 2004-08-31

Inventor: BEJGER THOMAS P [US]; ERAZO-MAJEWICZ PAQUITA [US]; HOPKINS DANIEL L [US]; KOSTAS JOHN N [US]; KUO PONG-KUEN P [US]; MODI JASHAWANT J [US]; XU ZU-FENG [US]

Title: Topical skin care compositions

Applicant/Assignee:

Application No.: 10/928823   Filing Date: 27/Aug/2004

Abstract:A novel combination of silicon resin, amorphous silica and low oil absorbing spherical powder is described which when added to topical skin care compositions containing high concentrations of active agents, improves their aesthetic feel and ease of application.

Priority:

Inventor: GONZALEZ ANTHONY D [US]; HUBBARD BARBARA J [US]; ANDERSON GLEN [US]; KALAFSKY ROBERT E [US]

Title: Cosmetic compositions

Applicant/Assignee: MOLECULAR RESEARCH CENTER, INC

Application No.: 10/925851   Filing Date: 25/Aug/2004

Abstract:A composition and method for improving skin appearance by reducing skin redness and symptoms associated with skin inflammation, irritation and skin aging by topically treating skin is disclosed. In this composition and method, an active material having the formula given below is applied to the patient at the site of said condition: wherein R<1 >is selected from -OH and C1-C3 alkyl OH

and R<2>, R<3>, R<4>, R<5 >and R<6 >are independently selected from -H, -OH, C1-C6 alkyl, and C3-C6 cycloalkyl. The active material should contain no more than five -OH groups. Preferred active materials include 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, 1,2,3-cyclohexanetriol, 1,3,5-cyclohexanetriol, and mixtures of those materials. A method of maintaining healthy hair and reducing hair loss using these actives is also disclosed.

Priority:

Inventor: CHOMCZYNSKI PIOTR [US]

Title: Compound for neck skin firming

Applicant/Assignee:

Application No.: 10/932690   Filing Date: 01/Sep/2004

Abstract:A topical compound for reducing sagging or wrinkles in the neck area of human skin. The compound includes safe and effective amounts of a mild topical astringent (such as Camphor) for skin tightening, a topical antispasmodic (such as benzyl cinnamate) for skin smoothing, and a topical skin irritant to increase localized skin circulation. The compound can also optionally include palmitoyl pentapeptide-3 to stimulate production of collagen and elastin in skin, a mushroom ferment extract to increase the cell turnover rate skin, and to increase hydration, skin firmness and elimination of fine facial lines, a cocao ferment extract to inhibit lipid peroxidation, inhibit excess ornithine decarboxylase activity, and stimulate cutaneous blood flow to reduce lines and wrinkles, and a Lactobacillus lysate extract to stimulate collagen production. These ingredients are mixed in a dermatologically acceptable carrier for topical application.

Priority:

Inventor: BROWN VERA [US]; FISHMAN YORUM [US]

Title: Novel use of aim 3 acting as a tumor suppressor

Applicant/Assignee:

Application No.: 10/536257   Filing Date: 25/May/2005

Abstract:The present invention relates to novel uses of AIM3 acting as a tumor suppressor, and more particularly to methods for using an AIM3 protein or a nucleic acid encoding the protein to activate ATM or ATR and to treat ATM- or ATR-mediated diseases. The AIM3 protein according to the present invention interacts directly with ATM/ATR so as to activate ATM/ATR and proteins regulated by ATM/ATR. Also, the AIM3 protein upregulates tumor suppressor gene p53 and its target genes so as to not only inhibit the proliferation of cells but also to induce apoptosis.

Priority: WO2004KR02202 Applic. Date: 2004-09-01

Inventor: KIM SUNGHOON [KR]

Title: Functional systems with reduced odor cationic polygalactomannan

Applicant/Assignee:

Application No.: 11/211001   Filing Date: 24/Aug/2005

Abstract:A reduced odor composition is composed of a functional system such as household care, personal care or pet care products and at least one cationic polygalactomannan or a derivative of cationic polygalactomannan having a cationic degree of substitution (DS) lower limit of about 0.01 and an upper limit of about 3.0 and weight average molecular weight (Mw) having a lower limit of 200,000 and an upper limit of 2,000,000 a concentration with a lower limit of 0.005 wt % and an upper limit of 10 wt %, and a trimethylamine content of less than 25 ppm, wherein the composition, at an alkaline pH, has no discernible amine odor.

Priority: US20040605556P Applic. Date: 2004-08-31

Inventor: ERAZO-MAJEWICZ PAQUITA [US]; MODI JASHAWANT M [US]

Title: Methods of producing lignin peroxidase and its use in skin and hair lightening

Applicant/Assignee: R.B.T. (RAKUTO BIO TECHNOLOGIES) LTD

Application No.: 10/538778   Filing Date: 10/Jun/2005

Abstract:Methods of producing lignin peroxidase are provided. Also provided are methods and cosmetic compositions suitable for skin and hair lightening as well as kits and an article-of manufacturing including active ingredients for skin and hair lightening.

Priority: US20020432678P Applic. Date: 2002-12-12; WO2003IL01055 Applic. Date: 2003-12-11

Inventor: BELINKY PAULA [IL]; LASSER HAIM [IL]; DOSORETZ CARLOS [IL]

Title: Composition for treatment of oily skin and acne prevention and methods of making and using same

Applicant/Assignee:

Application No.: 11/221431   Filing Date: 08/Sep/2005

Abstract:Compositions and methods for the prevention and treatment of oily skin and the prevention and treatment of open comedos and acne using the enzyme lipase and an acceptable carrier are disclosed.

Priority: US20040608015P Applic. Date: 2004-09-08

Inventor: SIVAK HANNAH N [US]

Title: Use of soluble CD26 as inhibitor of angiogenesis and inflammation

Applicant/Assignee:

Application No.: 11/208288   Filing Date: 18/Aug/2005

Abstract:The present invention relates to soluble CD26 or a biologically active variant of the soluble CD26 that effectively inhibits angiogenesis and inflammation in a mammalian subject, pharmaceutical compositions comprising the soluble CD26 and the use of soluble CD26 in methods of treatment.

Priority: US20040605013P Applic. Date: 2004-08-26

Inventor: CHANG CHIWEN [GB]

Title: Method of microencapsulation

Applicant/Assignee: TAGRA BIOTECHNOLOGIES LTD

Application No.: 11/208007   Filing Date: 22/Aug/2005

Abstract:The present invention provides methods for microencapsulation of active ingredients for topical application, whereby single-layer and multi-layer, preferably double-layer, microcapsules, are obtained. The microcapsules protect the active ingredients, maintain their original activity throught processing, formulation and storage, and enable controlled release of the active ingredient only upon application onto the skin.

Priority: GB19990027202 Applic. Date: 1999-11-17; US2002-130529 Applic. Date: 2002-09-30; WO2000IL00759 Applic. Date: 2000-11-16

Inventor: KVITNITSKY EMMA [IL]; SHAPIRO YURY [IL]; PRIVALOV OLGA [IL]; OLEINIK IRENA [IL]; POLISHER IGOR [IL]

Title: Antioxidant, skin preparation for external use, cosmetic and food

Applicant/Assignee: NICHIREI BIOSCIENCES INC

Application No.: 10/535382   Filing Date: 22/Jul/2005

Abstract:The invention relates to antioxidants that make effective use of acerola seeds, which have conventionally been discarded, that have high safety and excellent antioxidative effect in skin preparations for external use, cosmetics, and food, and that contain acerola seed extract as an active component. The invention also relates to skin preparations for external use, cosmetics, and food containing the antioxidant.

Priority: JP20020341191 Applic. Date: 2002-11-25; WO2003JP14885 Applic. Date: 2003-11-21

Inventor: NAGAMINE KENICHI [JP]; HAYASHI MIKI [JP]; YAMASAKI KAORI [JP]

Title: Perfume compositions

Applicant/Assignee:

Application No.: 10/521449   Filing Date: 14/Jan/2005

Abstract:A perfume composition comprising a perfume component capable of inhibiting the production of odoriferous steroids by micro-organisms on the skin. The perfume component is capable of inhibiting the biotransformation of androstadienols to androstenones.

Priority: GB20020016633 Applic. Date: 2002-07-18; GB20020027740 Applic. Date: 2002-11-28; WO2003GB03083 Applic. Date: 2003-07-16

Inventor: PERRING KEITH D [GB]; BRADSHAW DAVID J [GB]; BEHAN JOHN M [GB]; CAWKILL PAULA M [GB]

Title: Polyethylene glycol - peptide copper complexes and compositions and methods related thereto

Applicant/Assignee: PROCYTE CORPORATION

Application No.: 11/204772   Filing Date: 16/Aug/2005

Abstract:This invention relates to compositions comprising polyethylene glycol molecules coupled to peptide copper complexes, and, additionally, to such compositions formulated for use as pharmaceutical and cosmetic products, as well as to medical devices that comprise such compositions.

Priority: US20040602715P Applic. Date: 2004-08-18

Inventor: PATT LEONARD M [US]

Title: Method of cell growth inhibition with agnoprotein

Applicant/Assignee: TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OFHIGHER EDUCATION

Application No.: 10/517710   Filing Date: 27/Jul/2005

Abstract:The growth of normal and abnormally proliferating cells can be inhibited by the introduction of agnoprotein, or biologically active fragments or derivatives of agnoprotein, into the cell in the absence of any other polyoma virus protein or viral replication.

Priority: US20020388019P Applic. Date: 2002-06-12; WO2003US18519 Applic. Date: 2003-06-11

Inventor: KHALILI KAMEL [US]

Title: Tyrosinase activity cntrolling agent, process for producing the same and external preparations containing the same

Applicant/Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCEAND TECHNOLOGY TOYO BOSEKI KABUSHIKI KAISHA

Application No.: 10/530789   Filing Date: 08/Apr/2005

Abstract:Disclosed is a tyrosinase activity controlling agent comprising, as an active ingredient, a compound that has tyrosinase inhibiting or promoting activity, an external preparation comprising the controlling agent, and a process for producing the compound.

Priority: JP20020297040 Applic. Date: 2002-10-10; JP20020353403 Applic. Date: 2002-12-05; JP20030117973 Applic. Date: 2003-04-23; JP20030294543 Applic. Date: 2003-08-18; WO2003JP13018 Applic. Date: 2003-10-10

Inventor: TOKIWA YUTAKA [JP]; KITAGAWA MASARU [JP]; YOSHINO KENJI [JP]; YANAGIDANI SHUSAKU [JP]; RAKU TAKAO [JP]; TOTANI TETSUZO [JP]; SHIMAKAWA HIROMI [JP]

Title: Combination treatment of cancer with elicitor of gene product expression and gene-product targeting agent

Applicant/Assignee: INTROGEN THERAPEUTICS, INC

Application No.: 11/150521   Filing Date: 10/Jun/2005

Abstract:The present invention concerns cancer therapy employing an expression construct that affects regulation of one or more particular nucleic acid sequences that encodes a gene product to which an agent is then targeted. In specific embodiments, the present invention relates to the use of p53 gene therapy to treat cancers in combination with Erbitux(TM)(cetuximab). Viral and non-viral gene delivery systems are disclosed.

Priority: US20040579036P Applic. Date: 2004-06-11

Inventor: ROTH JACK A [US]; SCHUMACHER GUIDO [DE]; CHADA SUNIL [US]

Title: Bis-alkylbenzylamines

Applicant/Assignee:

Application No.: 10/531232   Filing Date: 13/Apr/2005

Abstract:Compounds of Formula (1), wherein R1 is hydrogen

C1-C18alkyl

trifluoromethyl

C3-C8cycloalkyl

phenylC1-C5alkyl

phenyl-C1-C5alkoxy

mono- or di-N-C1-C5alkamino-C1-C5alkyl

amino-di-N-C1-C5alkylamino-C1-C5alkyl

C1-C5alkoxy-C1-C5alkyl

R2 is C2-C20alkyl

hydroxy-C1-C20alkyl

phenyl

phenyl-C1-C5alkyl

phenyl-C1-C5alkoxy

mono- or di-N-C1-C5alkylamino-C1-C5alkyl

amino-di-N-C1-C5alkylamino-C1-C5alkyl

or heteroaryl-C1-C5alkyl

or R1 and R2 together with the nitrogen atom bonding them form a 5- to 7-membered monocyclic heterocyclic ring

are described. They are suitable for the antimicrobial treatment of surfaces, especially as antimicrobial active ingredients against gram-positive and gram-negative bacteri

Priority: EP20020405898 Applic. Date: 2002-10-21; CH20030000091 Applic. Date: 2003-01-22; WO2003EP11384 Applic. Date: 2003-10-14

Inventor: MARQUAIS-BIENEWALD SOPHIE [FR]; HOLZL WERNER [FR]; PREUSS ANDREA [CH]; MEHLIN ANDREAS [DE]; BRUNNER FREDERIC [CH]

Title: Hair loss prevention

Applicant/Assignee:

Application No.: 11/208864   Filing Date: 22/Aug/2005

Abstract:Compositions to prevent or reduce hair loss, allowing the body to maintain normal, healthy hair growth, comprising a penetration enhancer together with a testosterone blocker or a vascular enhancer, or both.

Priority: US2000-619142 Applic. Date: 2000-07-19

Inventor: KNOWLES W R [US]

Title: Methods and compositions for treatment of central and peripheral nervous system disorders and novel compounds useful therefor

Applicant/Assignee: ISREAL INSTITUTE FOR BIOLOGICAL RESEARCH ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH

Application No.: 10/512673   Filing Date: 08/Jul/2005

Abstract:There are provided methods for the treatment of diseases involving dysfunction of the peripheral and central nervous system comprising administering one or more spiro compounds. Also provided are pharmaceutical compositions useful in such methods, compounds for use in the preparation of such pharmaceutical compositions, processes for preparing compounds useful in the practice of such methods, and some novel such compounds per se.

Priority: US20020377433P Applic. Date: 2002-05-03; WO2003IL00357 Applic. Date: 2003-05-01

Inventor: FISHER ABRAHAM [IL]; BAR-NER NIRA [IL]; KARTON YISHAI [IL]

Title: 6H-[1]benzopyrano[4,3-b]quinolines and their use as estrogenic agents

Applicant/Assignee: WYETH

Application No.: 11/219940   Filing Date: 06/Sep/2005

Abstract:This invention provides 6H-[1]benzopyrano[4,3-b]quinoline compounds having the formula I:

Priority: US20040607766P Applic. Date: 2004-09-07

Inventor: VU AN T [US]

Title: Pharmaceutical and cosmeceutical wash-off mousse shampoo compositions, processes for preparing the same and uses thereof

Applicant/Assignee:

Application No.: 11/194582   Filing Date: 02/Aug/2005

Abstract:A pharmaceutical or cosmeceutical mousse shampoo composition formulated for application to hirsute areas, such as the human scalp, and containing an active pharmaceutical ingredient as well as a cleansing agent is disclosed. Methods of treatment using the same and processes of preparing the same are also disclosed.

Priority: US20040592405P Applic. Date: 2004-08-02

Inventor: ARKIN MOSHE [IL]; ZEEVI AMIRA [IL]; AVRAM NIR [IL]; UZAN RINA [IL]; SHILO-VOLIN HAGIT [IL]; HOLLANDER EREZ [IL]; BURIAKOVSKY OLGA [IL]

Title: Cosmetic use of a composition including an ascorbic acid compound and polyamide particles

Applicant/Assignee: L'OREAL

Application No.: 11/224959   Filing Date: 14/Sep/2005

Abstract:The present invention relates to the cosmetic use, for the care of greasy skin, of a composition including, in a physiologically acceptable medium, (a) at least one water-soluble ascorbic acid compound and (b) porous polyamide particles having a mean diameter, by volume, of less than or equal to 10 mum, provided that the composition is not a water-in-oil emulsion.

Priority: FR20040052074 Applic. Date: 2004-09-16; US20040612875P Applic. Date: 2004-09-27

Inventor: MARION CATHERINE [FR]

Title: Antigen-presenting cells for neuroprotection and nerve regeneration

Applicant/Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD

Application No.: 10/517666   Filing Date: 13/Dec/2004

Abstract:Pharmaceutical compositions and methods for preventing or inhibiting neuronal degeneration, or for promoting nerve regeneration, in the central nervous system (CNS) or peripheral nervous system (PNS), in the treatment of an injury, disorder or disease of the CNS or PNS, comprise antigen-presenting cells, preferably dendritic cells, that have been pulsed with an agent selected from the group consisting of: (a) a nervous system (NS)-specific antigen or an analog thereof

(b) a peptide derived from an NS-specific antigen or from an analog thereof, or an analog or derivative of said peptide

(c) a copolymer selected from the group consisting of Copolymer 1, a Copolymer 1-related peptide or polypeptide, and poly-Glu<50> Tyr<50>

and (d) a non-self antigen.

Priority: US20020388296P Applic. Date: 2002-06-14; WO2003IL00500 Applic. Date: 2003-06-12

Inventor: EISENBACH-SCHWARTZ MICHAL [IL]; COHEN AVRAHAM [IL]

Title: Novel adenoviruses, nucleic acids coding therefor, and use thereof

Applicant/Assignee:

Application No.: 10/531366   Filing Date: 14/Apr/2005

Abstract:The present invention is related to an adenovirus expressing a first protein which is selected from the group comprising an E1B protein and an E4 protein, priorto a second protein which is selected from the group comprising an E1A protein.

Priority: DE20021048039 Applic. Date: 2002-10-15; DE20031022530 Applic. Date: 2003-05-19; DE20031024085 Applic. Date: 2003-05-27; WO2003EP05583 Applic. Date: 2003-05-27; WO2003EP11427 Applic. Date: 2003-10-15

Inventor: HOLM PER S [DE]

Title: Microemulsion process and composition

Applicant/Assignee: CONNETICS AUSTRALIA PTY LTD

Application No.: 11/216668   Filing Date: 31/Aug/2005

Abstract:There is provided a process for the preparation of an oil in water (O/W) microemulsion or sub-micron emulsion composition for dermal delivery of at least one pharmaceutically active ingredient, the method including the steps of a) Admixing a first part including at least one of the group consisting of animal, mineral or vegetable oils, silanes, siloxanes, esters, fatty acids, fats, halogen compounds or alkoxylated alcohols

and one or more lipophilic surfactants, and a second part including water and at least one hydrophilic surfactant to achieve homogeneity, b) heating the mix of step a) to a phase assembly temperature in the range of 40-99 DEG C., preferably 45-95 DEG C., more preferably 65-85 DEG C. with continuous mixing to obtain a microemulsion or sub-micron emulsion, c) allowing said microemulsion or sub-micron emulsion to cool, and d) adding a third part to said microemulsion or sub-micron emulsion at a temperature between 2 DEG C. and said phase assembly temperature, said third part if necessary being premixed and heated until the components are dissolved and including at least one component selected from the group consisting of non-surfactant amphiphilic type compound, surfactant and water with the proviso that when the third part includes water it also includes a non-surfactant amphiphilic type compound and/or surfactant. The phase assembly temperature can be determined visually by the achievement of translucence in the composition or by measures such as conductivity which peaks and then is maintained at a plateau whilst phase assembly occurs. It has been found that whilst if a non-surfactant amphiphilic type compound such as the polyol is added together with the second part as would conventionally be the case, a microemulsion or sub-micron emulsion is not formed, by adding the so called third part, phase assembly occurs at a lower temperature than would be expected and moreover, this phase appears to assist in maintaining the microemulsion or sub-micron emulsion characteristics of the formulation during storage at normal temperatures.

Priority: US20050670722P Applic. Date: 2005-04-12; US20040606278P Applic. Date: 2004-08-31

Inventor: LARM MARIA G [AU]; HARDING RONALD [AU]

Title: Broad spectrum preservation blends

Applicant/Assignee: ARCH CHEMICALS, INC

Application No.: 11/224397   Filing Date: 12/Sep/2005

Abstract:A composition having effective broad spectrum preservation activity comprising a mixture of caprylyl glycol or one or more analogs thereof, or mixtures thereof with a preservative selected from the group consisting of: (1) chloroxylenol and 2-phenoxyethanol, (2) chloroxylenol and chlorphenesin, (3) chlorphenesin and 2-phenoxyethanol, and (4) chloroxylenol, chlorphenesin and 2-phenoxyethanol.

Priority: US20040610772P Applic. Date: 2004-09-16

Inventor: CICCOGNANI DIANA T [US]; DINICOLA KEVIN N [US]; HINDEN STEPHEN D [US]; ROBERTS KATHERINE P [US]

Title: External skin preparations for suppressing sebum secretion

Applicant/Assignee: SHISEIDO COMPANY, LTD

Application No.: 11/270438   Filing Date: 10/Nov/2005

Abstract:A drug for external application to the skin, for inhibiting sebum secretion, comprising a matrix metalloproteinase inhibitor.

Priority: JP20000197309 Applic. Date: 2000-05-26; JP20010151391 Applic. Date: 2001-05-21; US2002-277000 Applic. Date: 2002-11-20; WO2001JP04336 Applic. Date: 2001-05-23

Inventor: INOMATA SHINJI [JP]; KOBAYASHI KOJI [JP]

Title: Extract with anti-tumor and anti-poisonous activity

Applicant/Assignee:

Application No.: 10/530905   Filing Date: 08/Apr/2005

Abstract:Extracts of the plant Calotropis procera, having a pharmacological activity, in particular an anti-poisonous activity, and active compounds isolated thereof are described. Furthermore, methods for the extraction of the extracts are disclosed. Also, a pharmaceutical composition or product for the treatment of cancer which includes an effective amount of the described extracts or an active compound thereof, a therapeutic compound and optionally a pharmaceutical acceptable carrier are described.

Priority: WO2002EP11310 Applic. Date: 2002-10-09; WO2003EP11192 Applic. Date: 2003-10-09

Inventor: DARRO FRANCIS [BE]; BRAEKMAN JEAN-CLAUDE [BE]; GUISSOU PIERRE [BF]; NACOULMA ODILE G [BF]; EL YAZIDI MOHAMED [BE]; DEWELLE JANIQUE [BE]; VAN GINKEL ROB [BE]; VAN DAMME MARC [BE]; KISS ROBERT [BE]

Title: Sanitizing wipes with microbicidal properties cross-reference to related applications

Applicant/Assignee:

Application No.: 11/130455   Filing Date: 16/May/2005

Abstract:A biodegradable sanitizing and microbicidal wipe composition using food additive ingredients or ingredients regarded as safe by the FDA. The wipes hereof are safe for sanitizing and disinfecting food, food contact, and environmental surfaces and skin, hands and other body parts.

Priority: US20040611559P Applic. Date: 2004-09-20

Inventor: LOPES JOHN A [US]

Title: Dual activating TDD

Applicant/Assignee:

Application No.: 10/945658   Filing Date: 21/Sep/2004

Abstract:Preferred embodiment FIG. 1 , comprises a novel transdermal delivery device for ensuring longer shelf life of unstable drugs comprising a patch for disbursement of therapeutic drugs to the skin of a user

said patch comprising an inbuilt injection port in which the user injects the diluent and/or active ingredient(s) into the drug reservoir to activate said drug delivery device, wherein the device comprises various permeablity rate-controlling membranes to accommodate a specific drug being introduced to the device, wherein upon removing the protective outer layer, of the preferred embodiment FIG. 1 . the device is ready to be placed on the skin by the patient. Additional embodiment replaces the injection port with a separate sealed diluent pouch reservoir.

Priority:

Inventor: PUTMAN ROGER T SR [US]

Title: BIOSYNCHRONOUS TRANSDERMAL DRUG DELIVERY

Applicant/Assignee: CHRONO THERAPEUTICS, INC

Application No.: 11/162525   Filing Date: 13/Sep/2005

Abstract:Systems and methods for treating diseases, addictions and disorders in humans and animals involving synchronizing and tailoring the administration of drug compounds with the body's natural circadian rhythms, in order to counteract symptoms when they are likely to be at their worst. Automated and pre programmable transdermal drug administration system are used. This system can also utilize a pump or pressurized reservoir, and/or a system for removing depleted carrier solution, or other modulated dispensing actuator, in conjunction with micro-fabricated structures commonly referred to as Micro-needles, or heat, or iontophoresis, sonophoresis, or a wide range of chemical permeation enhancers.

Priority: US20040609418P Applic. Date: 2004-09-13; US2005-162517 Applic. Date: 2005-09-13

Inventor: DIPIERRO GUY [US]; GIANNOS STEVEN A [US]

Title: Composition and method to optimize and customize nutritional supplement formulations by measuring genetic and metabolomic contributing factors to disease diagnosis, stratification, prognosis, metabolism, and therapeutic outcomes

Applicant/Assignee:

Application No.: 11/197980   Filing Date: 05/Aug/2005

Abstract:The present invention relates to a composition and custom business model and methods to measure genetic and metabolomic contributing factors affecting disease diagnosis, stratification, and prognosis, as well as the metabolism, efficacy and/or toxicity associated with specific vitamins, minerals, herbal supplements, homeopathic ingredients, and other ingredients for the purposes of customizing a subject's nutritional supplements with custom formulations to optimize health outcomes.

Priority: US20040599829P Applic. Date: 2004-08-05

Inventor: BLUM KENNETH [US]; MESHKIN BRIAN [US]; DOWNS BERNARD W [US]

Title: DNA encoding the human serine protease C-E

Applicant/Assignee:

Application No.: 10/988164   Filing Date: 12/Nov/2004

Abstract:Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease C-E. The deduced amino acid sequence, and it alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease C-E mRNA is expressed in pancreas, placenta, prostate, small intestine, stomach, spleen, fibroblasts and epidermis, as well as in certain regions of the brain i.e., cerebellum, cerebral cortex, pituitary and hippocampus. Enzymatically active protease C-E, as produced using the methodologies described herein, is amenable to further biochemical analyses for the identification of physiological substrates and specific modulators.

Priority: US2002-040803 Applic. Date: 2002-01-07; US1999-386629 Applic. Date: 1999-08-31

Inventor: DARROW ANDREW [US]; QI JENSON [US]; ANDRADE-GRODON PATRICIA [US]

Title: Compositions and methods for gene therapy

Applicant/Assignee:

Application No.: 11/253435   Filing Date: 18/Oct/2005

Abstract:The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) physically linked to a transfection agent for use in embolization gene therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions., using the injectable compositions.

Priority: US2002-220983 Applic. Date: 2002-12-12; WO2001US09618 Applic. Date: 2001-03-23; US20000191902P Applic. Date: 2000-03-24

Inventor: VOGEL JEAN-MARIE [US]; BOSCHETTI EGISTO [FR]

Title: Composition based on triethyl citrate for the treatment of bacterial infections of the skin

Applicant/Assignee:

Application No.: 10/526152   Filing Date: 24/Feb/2005

Abstract:This invention concerns a composition for topical use containing as an active ingredient triethyl citrate either pure or in combination with synergists, and the pharmaceutical or cosmetic use of the composition, on its own or in association with an antibiotic, at least in the treatment of cutaneous pathologies directly or indirectly affected by bacterial infections.

Priority: IT2002BS00078 Applic. Date: 2002-09-02; WO2003IT00530 Applic. Date: 2003-09-02

Inventor: DE PAOLI AMBROSI GIANFRANCO [IT]

Title: Washable marker ink composition

Applicant/Assignee: MATTEL, INC

Application No.: 10/944980   Filing Date: 20/Sep/2004

Abstract:The present invention provides a fluorescent marker ink coloring composition incorporating an optical brightener, a film-forming agent, an aqueous carrier, and a colorant. The optical brightener is an amphoteric distyryl fluorescent whitener which generates a special effect in the dried marking ink composition. The coloring composition can optionally include one or more of a humectant, a surfactant, a preservative, a drying agent, a pH regulant, a bittering agent or a fragrance. The present invention further provides a writing instrument comprising the coloring composition.

Priority:

Inventor: CORDOVA ABIMAEL [US]

Title: Film-forming compositions for protecting skin from body fluids and articles made therefrom

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 11/273355   Filing Date: 14/Nov/2005

Abstract:The present invention relates to a film-forming barrier composition useful for protecting the skin from body fluids, such as urine, feces, menses. The composition comprises a skin conditioning agent, a viscosity enhancing agent and an oleophilic film-forming agent. Optionally, the lotion may comprise skin care ingredients for treating or maintaining skin health. The composition may be applied to the skin by suitable delivery vehicles, such as absorbent articles or components thereof, sheet materials, pads, bandages, sponges, foam pads, pumps, sprays, depending on the viscosity of the composition.

Priority: US2001-898880 Applic. Date: 2001-07-03

Inventor: KLOFTA THOMAS J [US]; STAUDIGEL JAMES A [US]; DECKNER GEORGE E [US]

Title: UV-absorbing lipid vesicles

Applicant/Assignee: GALAXY SURFACTANTS LIMITED

Application No.: 10/953832   Filing Date: 29/Sep/2004

Abstract:Highly effective vesicular compositions from UV-absorbing lipids are described in the present invention. Combination of UV-absorbing property and the vesicular delivery system results in higher levels of photoprotection to skin and hair. The vesicular compositions of the present invention are made from cationic UV-absorbing lipids of Formula I wherein,

Priority:

Inventor: KOSHTI NIRMAL M [IN]; NAIK SHUBHANGI D [IN]; JADHAV TANAJI S [IN]

Title: Film foaming hydroalcoholic foam

Applicant/Assignee: CONNETICS AUSTRALIA PTY LTD

Application No.: 11/187217   Filing Date: 22/Jul/2005

Abstract:The present invention provides a foam composition comprising an active agent. In particular, the foam composition produces a water resistant, preferably very water resistant, film upon application.

Priority: WO2004AU00170 Applic. Date: 2004-02-12; US20030447445P Applic. Date: 2003-02-12

Inventor: HUGGINS JOAN K [AU]; HOULDEN ROBERT J [AU]

Title: Antiperspirant compositions

Applicant/Assignee: ISP INVESTMENTS INC

Application No.: 10/952949   Filing Date: 29/Sep/2004

Abstract:What is described herein is an antiperspirant composition including an active antiperspirant ingredient, and a phenylethyl, benzyl or substituted benzyl ester as additive therein, which is an aryl carboxylic ester of 2-phenylethyl alcohol, 1-phenylethyl alcohol or benzyl alcohol, which leaves a reduced visible white chalky residue on the skin of the user.

Priority:

Inventor: BERTZ STEVEN H [US]; OROFINO STEVEN A [US]; GOMEZ BLANCA [US]

Title: Methods and compositions related to the modulation of intercellular junctions

Applicant/Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Application No.: 11/171490   Filing Date: 29/Jun/2005

Abstract:The invention relates to compositions and methods for the modulation of the permeability of the epithelial cell barrier complex. In particular, the invention provides compositions and methods for using polysaccharides, preferably glycosaminoglycans, and agents that modify cell surface glycosaminoglycans, preferably glycosaminoglycan-degrading enzymes to modulate intercellular junctions. The compositions and methods provided can be used to facilitate the delivery of biologically active molecules.

Priority: US20040584438P Applic. Date: 2004-06-29

Inventor: CHANDRASEKARAN AARTHI [US]; SENGUPTA SHILADITYA [US]; BERRY DAVID A [US]; HOLLEY KRISTINE [US]; ZHAO GANLIN [US]; SASISEKHARAN RAM [US]

Title: Stabilization of alum-adjuvanted immunologically active agents

Applicant/Assignee:

Application No.: 11/237200   Filing Date: 27/Sep/2005

Abstract:A composition and method for formulating and delivering an adjuvanted immunological active agent, especially a vaccine, wherein adjuvant coagulation and concomitant loss of vaccine efficacy enhancement is mitigated or avoided. The adjuvanted, immunologically-active agent can be subjected to freezing, drying, freeze-drying, or lyophilization, and when reconstituted, retains a high level of potency. The present invention further provides for a composition and method for formulating and delivering a stable, adjuvanted, immunologically-active agent capable of being deposited on a transdermal delivery device or microprojection or array thereof.

Priority: US20040614161P Applic. Date: 2004-09-28; US20050649275P Applic. Date: 2005-01-31

Inventor: MAA YUH-FUN [US]; SELLERS SCOTT [US]

Title: Self-heating cosmetic products

Applicant/Assignee:

Application No.: 10/542536   Filing Date: 18/Jul/2005

Abstract:The invention refers to cosmetic products having a self-warming effect. The composition is substantially water-free and contains 0.1 to 40% by weight of a hydrophilic aluminum-rich zeolite with a pore size in the range of 0.3 to 0.5 nm, 1 to 99% by weight of a disperse oil phase, 0.1 to 50% by weight of a non-ionic surface-active agent, 0.1 to 40% by weight of an emollient, 0.1 to 20% by weight of a thickener, and up to 100% by weight cosmetic carrier substances, auxiliary substances, active substances and mixtures thereof, with the provisio that no polyvalent alcohols and polar solvents are contained. The products have an enhanced water absorption, cleansing effect and a silk-like feeling.

Priority: DE20031002096 Applic. Date: 2003-01-16; WO2004EP00317 Applic. Date: 2004-01-16

Inventor: HWANG DONNA H [US]; CERNASOV DOMNICA [US]; MACCHIO RALPH [US]

Title: Compositions and methods for treating angiogenesis-related diseases, wounds and cosmetic use of components of Angelica sinensis, and methods of preparation thereof

Applicant/Assignee: SUNNY BIODISCOVERY, INC

Application No.: 10/948590   Filing Date: 24/Sep/2004

Abstract:Compositions and methods for treating angiogenesis-related diseases and for skin care in mammals is disclosed that includes, as an active pharmaceutical agent, an effective amount of purified extract from Angelica sinensis, or a fraction or a lyophilizate thereof, or one or more active component contained in said extract.

Priority:

Inventor: ZHAO HUI [US]; BOJANOWSKI KRZYSZTOF [US]; ARIA FARIBA [US]; MORTEZAEI REZA [US]

Title: AChE antisense oligonucleotide as an anti-inflammatory agent

Applicant/Assignee:

Application No.: 11/187719   Filing Date: 21/Jul/2005

Abstract:Disclosed is a novel use for AChE antisense oligonucleotides as anti-inflammatory agents, wherein said oligonucleotides are preferably as denoted by SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:7. Methods of treatment of inflammatory conditions, as well as fever, and particularly inflammation-associated neuropathies such as Guillain-Barré Syndrome, are described.

Priority: IL20030158600 Applic. Date: 2003-10-26; WO2004IL00978 Applic. Date: 2004-10-26

Inventor: SOREQ HERMONA [IL]; DORI AMIR [IL]; WIRGUIN ITZHAK [IL]; IFERGANE GAL [IL]; YIRMIYA RAZ [IL]

Title: Medicaments containing xenogeneic oligo- and/or polyribonucleotides

Applicant/Assignee:

Application No.: 11/250067   Filing Date: 13/Oct/2005

Abstract:The invention relates to medicaments that contain xenogenic oligo- or/and polyribonucleotides as the effective component. The invention further relates to the use of said xenogenic oligo- or/and polyribonucleotides for treating herpesviridae infections and skin tumors.

Priority: DE19991040748 Applic. Date: 1999-08-27; US2002-049216 Applic. Date: 2002-04-18; WO2000EP08279 Applic. Date: 2000-08-24

Inventor: SEINFELD HUGO [DE]

Title: Methods and compositions for the treatment of diseases characterized by pathological calcification

Applicant/Assignee: NANOBAC PHARMACEUTICALS, INC

Application No.: 11/102798   Filing Date: 11/Apr/2005

Abstract:Methods and compositions are provided which contains preparations of calcium chelators, bisphosphonates, antibiotics, antimicrobial agents, cytostatic agents, calcium ATPase and pyrophosphatase pump inhibitors, calcium phosphate-crystal dissolving agents, agents effective against calcium phosphate-crystal nucleation and crystal growth, and/or a combination of supportive agents and which may be used for treating and or reducing pathological calcifications, the growth of Nanobacterium and calcification-induced diseases including, but not limited to, Arteriosclerosis, Atherosclerosis, Coronary Heart Disease, Chronic Heart Failure, Valve Calcifications, Arterial Aneurysms, Calcific Aortic Stenosis, Transient Cerebral Ischemia, Stroke, Peripheral Vascular Disease, Vascular Thrombosis, Dental Plaque, Gum Disease (dental pulp stones), Salivary Gland Stones, Chronic Infection Syndromes such as Chronic Fatigue Syndrome, Kidney and Bladder Stones, Gall Stones, Pancreas and Bowel Diseases (such as Pancreatic Duct Stones, Crohn's Disease, Colitis Ulcerosa), Liver Diseases (such as Liver Cirrhosis, Liver Cysts), Testicular Microliths, Chronic Calculous Prostatitis, Prostate Calcification, Calcification in Hemodialysis Patients, Malacoplakia, Autoimmune Diseases. Erythematosus, Scleroderma, Dermatomyositis, Antiphospholipid Syndrome, Arteritis Nodosa, Thrombocytopenia, Hemolytic Anemia, Myelitis, Livedo Reticularis, Chorea, Migraine, Juvenile Dermatomyositis, Grave's Disease, Hypothyreoidism, Type 1 Diabetes Mellitus, Addison's Disease, Hypopituitarism, Placental and Fetal Disorders, Polycystic Kidney Disease, Glomerulopathies, Eye Diseases (such as Corneal Calcifications, Cataracts, Macular Degeneration and Retinal Vasculature-derived Processes and other Retinal Degenerations, Retinal Nerve Degeneration, Retinitis, and Iritis), Ear Diseases (such as Otosclerosis, Degeneration of Otoliths and Symptoms from the Vestibular Organ and Inner Ear (Vertigo and Tinnitus)), Thyroglossal Cysts, Thyroid Cysts, Ovarian Cysts, Cancer (such as Meningiomas, Breast Cancer, Prostate Cancer, Thyroid Cancer, Serous Ovarian Adenocarcinoma), Skin Diseases (such as Calcinosis Cutis, Calciphylaxis, Psoriasis, Eczema, Lichen Ruber Planus), Rheumatoid Arthritis, Calcific Tenditis, Osteoarthritis, Fibromyalgia, Bone Spurs, Diffuse Interstitial Skeletal Hyperostosis, Intracranial Calcifications (such as Degenerative Disease Processes and Dementia), Erythrocyte-Related Diseases involving Anemia, Intraerythrocytic Nanobacterial Infection and Splenic Calcifications, Chronic Obstructive Pulmonary Disease, Broncholiths, Bronchial Stones, Neuropathy, Calcification and Encrustations of Implants, Mixed Calcified Biofilms, and Myelodegenerative Disorders (such as Multiple Sclerosis, Lou Gehrig's and Alzheimer's Disease) in humans and animals. The method comprises administering the various classes of compositions of the present invention, which together effectively inhibit or treat the development of calcifications in vivo.

Priority: US2004-891483 Applic. Date: 2004-07-15

Inventor: KAJANDER E O [US]; AHO K M [FI]; CIFTCIOGLU N [US]; MILLICAN B [US]

Title: Methods and compositions for the administration of calcium chelators, bisphosponates and/or citrate compounds and their pharmaceutical uses

Applicant/Assignee: NANOBAC PHARMACEUTICALS, INC

Application No.: 11/180921   Filing Date: 14/Jul/2005

Abstract:A composition is provided which contains calcium chelators, bisphosphonates, and/or citrate compounds and which may be used for treating and or reducing pathological calcifications, heavy metal poisoning, the growth of Nanobacterium Calcifying Nano-Particles and calcification-induced diseases in humans and animals. The method includes administering a therapeutic composition of calcium chelators, bisphosphonates, and/or citrate compounds which effectively inhibit or treat the development of calcifications in vivo. Typically, the administered composition includes about 0.1-10:1 parts by weight of calcium chelators, bisphosphonates, and/or citrate compounds.

Priority: US20040587869P Applic. Date: 2004-07-15

Inventor: KAJANDER E O [FI]; AHO K M [FI]; CIFTCIOGLU NEVA [US]; MILLICAN B [US]

Title: Novel complexes of fatty acid esters of polyhydroxyalkanes and pyridine carboxy derivatives

Applicant/Assignee: ASTION DERMATOLOGY A/S

Application No.: 10/517592   Filing Date: 15/Aug/2005

Abstract:The present invention relates to novel combinations of fatty acid derivatives and pyridine carboxy derivatives, including fatty acid esters with glycerol and 3-carboxy pyridine derivatives such as niacinamide. Such combinations have surprisingly shown antiviral and anti-microbial activity and the use for the treatment of inflammatory conditions and infections is disclosed herein.

Priority: DK20020000951 Applic. Date: 2002-06-20; US20020389879P Applic. Date: 2002-06-20; WO2003DK00423 Applic. Date: 2003-06-20

Inventor: WEIDNER MORTEN S [DK]

Title: Textile treatment agent

Applicant/Assignee:

Application No.: 11/230199   Filing Date: 19/Sep/2005

Abstract:A textile aftertreatment composition comprising (a) a skin-protecting oil and (b) urea and/or urea derivative

lactic acid and/or a lactic salt

citric acid and/or a citric acid salt wherein the composition is in the form of an emulsion. The composition is conducive directly or indirectly to the health of the skin and can be used as a supplement to the classical textile treatment compositions such as laundry detergents or fabric softeners.

Priority: DE20031011852 Applic. Date: 2003-03-17; WO2004EP02232 Applic. Date: 2004-03-05

Inventor: RAEHSE WILFRIED [DE]; RUFFER ULRIKE [DE]

Title: High DS cationic polygalactomannan for skincare products

Applicant/Assignee:

Application No.: 11/223525   Filing Date: 09/Sep/2005

Abstract:A skin care composition is provided with a) from about 1 to about 90 wt % of a surfactant, b) at least about 0.05 wt % of a cationic polymer wherein the cationic polymer has a mean average molecular weight (Mw) from about 2,000 to about 10,000,000 Dalton, and the cationic polymer has a cationic degree of substitution (DS) greater than 0.25 to about 3.0, and c) at least one skin care active ingredient, wherein the skin care composition provides at least one of the functions of cleansing, protection, moisturizing, firming, conditioning, occlusive barrier, emolliency, depositing, and anti-wrinkling to the skin.

Priority: US20040613007P Applic. Date: 2004-09-24

Inventor: MODI JASHAWANT J [US]

Title: Conveniently implantable sustained release drug compositions

Applicant/Assignee:

Application No.: 11/236426   Filing Date: 27/Sep/2005

Abstract:This invention provides for biocompatible and biodegradable syringeable liquid, implantable solid, and injectable gel pharmaceutical formulations useful for the treatment of systemic and local disease states.

Priority: US20040614484P Applic. Date: 2004-10-01; US20050709665P Applic. Date: 2005-08-19

Inventor: WONG VERNON G [US]; WOOD LOUIS L [US]

Title: Penetrating carrier, anti-fungal composition using the same and method for treatment of dermatophytes

Applicant/Assignee:

Application No.: 10/956073   Filing Date: 04/Oct/2004

Abstract:A liquid carrier for topical administration is provided that contains a mineral oil, turpentine and, optionally, camphor, and optionally other terpenoid components containing pinene, and its use to provide an antifingal composition a mixture of antifungal essential oils and the carrier system, wherein the mixture of antifungal essential oils includes an effective amount of each of eucalyptus globulus, peppermint, cedarwood, and Manuka

along with the use of this composition in the topical treatment of fungal infection, particularly of the nail.

Priority:

Inventor: SELNER MARC [US]

Title: Therapeutic stem cell growth factor composition, anti-inflammatory composition, and uses thereof

Applicant/Assignee: IMMUNOPATH PROFILE, INC

Application No.: 11/212530   Filing Date: 26/Aug/2005

Abstract:The present invention relates to a composition and uses thereof for treatment of damaged tissue comprising at least one essential amino acid in L form and at least one essential lipid

wherein the composition is administered to a mammal suffering from severe tissue damage. The invention further relates to a composition and uses thereof comprising a mixture of one or more free L-amino acids in which the molar ratio of the free L-amino acids corresponds to the molar ratio of amino components in a mammalian tissue protein

and at least one essential lipid.

Priority: US2000-639859 Applic. Date: 2000-08-16; US19990149338P Applic. Date: 1999-08-17

Inventor: GIRSH LEONARD S [US]

Title: Regulation of mammalian keratinous tissue using hexamidine compositions

Applicant/Assignee:

Application No.: 11/246317   Filing Date: 07/Oct/2005

Abstract:A method of facilitating the cosmetic delivery of a hexamidine compound to keratinous tissue via a composition including the hexamidine compound, including the step of incorporating a thickening agent that is not negatively-charged into the composition.

Priority: US2004-780267 Applic. Date: 2004-02-17; US2003-379252 Applic. Date: 2003-03-04

Inventor: BISSETT DONALD L [US]; CLEAR ROSE M [US]; ROBINSON LARRY R [US]

Title: Cosmetic compositions containing fluorescent colorants for natural skin appearance

Applicant/Assignee:

Application No.: 11/205570   Filing Date: 17/Aug/2005

Abstract:Cosmetic or personal care compositions which comprise at least one fluorescent colorant other than white and at least one non-fluorescent colorant, are useful in preparing colored cosmetic or personal care preparations providing an enhanced skin appearance.

Priority: US20040603591P Applic. Date: 2004-08-23

Inventor: ELDER STEWART T [US]; MORTON COLIN J H [CH]; ANDRIANOV CHRISTINA L [US]

Title: Use of the residues from wine production

Applicant/Assignee:

Application No.: 11/229295   Filing Date: 16/Sep/2005

Abstract:A cosmetic or pharmaceutical preparation comprising a winemaking residue is comprised of from about 1 to about 10% by weight of polyphenols and from about 25 to about 50% by weight of proteins, based on the dry residue weight. The press residues obtained in the flocculation of the fermented grape juice contain synergistic mixtures of polyphenols and proteins from the yeasts and increase the efficacy of the cosmetic or pharmaceutical preparations into which they are added for countering the effects of skin aging and damage to fibroblasts and kerotinocytes caused by UV-A and UV-B radiation.

Priority: FR19990016868 Applic. Date: 1999-12-22; US2002-399593 Applic. Date: 2002-06-21; WO2000EP12650 Applic. Date: 2000-12-13

Inventor: PAULY GILLES [FR]; HENRY FLORENCE [FR]

Title: Organo-gel formulations for therapeutic applications

Applicant/Assignee: MEDIQUEST THERAPEUTICS, INC

Application No.: 10/960516   Filing Date: 08/Oct/2004

Abstract:A composition suitable for the local delivery of cosmetic and/or pharmaceutical agents into the skin containing at least two biocompatible organic solvents, a polar lipid, a surfactant, water, urea and a thickener wherein the organic solvents include an ester and a dihydric and/or polyhydric alcohol is provided. Also disclosed are compositions that further contain a cosmetic and/or pharmaceutical agent, along with the preparation and use thereof.

Priority:

Inventor: DECHOW FREDERICK J [US]

Title: Organo-gel formulations for therapeutic applications

Applicant/Assignee: MEDIQUEST THERAPEUTICS, INC

Application No.: 11/066485   Filing Date: 28/Feb/2005

Abstract:A composition suitable for the local delivery of cosmetic and/or pharmaceutical agents into the skin containing at least two biocompatible organic solvents, a polar lipid, a surfactant, water, urea and a thickener wherein the organic solvents include an ester and a dihydric and/or polyhydric alcohol is provided. Also disclosed are compositions that further contain a cosmetic and/or pharmaceutical agent, along with the preparation and use thereof.

Priority: US2004-960516 Applic. Date: 2004-10-08

Inventor: DECHOW FREDERICK J [US]

Title: Organo-gel formulations for therapeutic applications

Applicant/Assignee: MEDIQUEST THERAPEUTICS, INC

Application No.: 11/150254   Filing Date: 13/Jun/2005

Abstract:A composition suitable for the local delivery of cosmetic and/or pharmaceutical agents into the skin containing at least two biocompatible organic solvents, a polar lipid, a surfactant, water, urea and a thickener wherein the organic solvents include an ester and a dihydric and/or polyhydric alcohol is provided. Also disclosed are compositions that further contain a cosmetic and/or pharmaceutical agent, along with the preparation and use thereof.

Priority: US2005-066485 Applic. Date: 2005-02-28; US2004-960516 Applic. Date: 2004-10-08

Inventor: DECHOW FREDERICK J [US]

Title: Transdermal therapeutic system suitable for heat application for promoting the permeation of active substances, and the use thereof

Applicant/Assignee: LTS LOHMANN THERAPIE-SYSTEME AG

Application No.: 10/544565   Filing Date: 05/Aug/2005

Abstract:The invention relates to a transdermal therapeutic system (TTS) comprising at least one pharmacological active substance, which is suitable for heating up to a temperature above skin temperature, thereby promoting the permeation rate of the active substance. The transdermal therapeutic system comprises at least one layer containing the active substance and one peelable backing layer, and is characterize in that the layer containing the active substance mainly consists of a polysiloxane in which the active substance is partially dissolved.

Priority: DE20031004989 Applic. Date: 2003-02-07; DE200410003224 Applic. Date: 2004-01-22; WO2004EP00944 Applic. Date: 2004-02-03

Inventor: MULLER WALTER [DE]

Title: Method for obtaining anti-idiotype antibodies

Applicant/Assignee: OMRIX BIOPHARMACEUTICALS INC

Application No.: 10/515499   Filing Date: 06/Sep/2005

Abstract:A method for identifying molecules which mimic an idiotype of an autoimmune disease-associated auto-antibody (autoantibodies). The method comprises the following steps: (a) purifying autoantibodies from sera of one or more patients afflicted with the autoimmune disease

(b) binding the autoantibodies to a solid phase to form an affinity matrix

(c) contacting pooled plasma or B cells comprising immunoglobulins with the affinity matrix followed by removal of unbound plasma components

(d) eluting bound immunoglobulins, being anti-Idiotypic antibodies (anti-Id) to autoantibodies, from the matrix

(e) providing a molecular library comprising a plurality of molecule members

and (e) contacting the anti-Id with the molecular library and isolating those bound molecules which are bound by the anti-Id, the bound molecules being molecules which mimic an idiotype of autoantibodies. Also disclosed are such molecules.

Priority: US20020383136P Applic. Date: 2002-05-28; WO2003IL00424 Applic. Date: 2003-05-22

Inventor: NUR ISRAEL [IL]; SHOENFELD YEHUDA [IL]

Title: Depositable solids

Applicant/Assignee:

Application No.: 11/198364   Filing Date: 05/Aug/2005

Abstract:A stable, rinsable multi-phase personal care composition is described comprising at least two visually distinct phases. At least one visually distinct phase comprises from about 1% to about 99% of a depositable solid by weight of the composition

and wherein said stable multi-phase personal care composition provides at least about 0.2% Depositable Solids.

Priority: US20040617392P Applic. Date: 2004-10-08; US20040628036P Applic. Date: 2004-11-15; US20050680116P Applic. Date: 2005-05-12

Inventor: WAGNER JULIE ANN [US]; WEI KARL SHIQING [US]; SMITH EDWARD DEWEY III [US]; MIDHA SANJEEV [US]; HEINRICH JAMES MERLE [US]

Title: Personal care composition containing a cleansing phase and a benefit phase

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 11/227379   Filing Date: 15/Sep/2005

Abstract:Personal care compositions comprising a cleansing phase and a benefit phase. These products are intended to provide a multi-phase personal care composition that is packaged in physical contact while remaining stable and providing improved in-use and after-use hair and skin benefits.

Priority: US20040617392P Applic. Date: 2004-10-08

Inventor: MIDHA SANJEEV [US]; WELLS ROBERT L [US]; COMSTOCK BRYAN G [US]; HEINRICH JAMES M [US]; NIEBAUER MICHAEL F [US]

Title: Substituted compounds derived from N-(benzyl)phenylacetamide, preparation and uses

Applicant/Assignee: GENFIT

Application No.: 11/235707   Filing Date: 27/Sep/2005

Abstract:This invention relates to poly-substituted derivatives of the N-(benzyl)phenylacetamide type, pharmaceutical compositions comprising same, therapeutic uses thereof, more particularly in the fields of human and animal health. This invention also relates to a process for the preparation of such derivatives.

Priority: FR20040010192 Applic. Date: 2004-09-27

Inventor: MASSON CHRISTOPHE [FR]; CAUMONT-BERTRAND KARINE [FR]

Title: Photostable photoprotective compositions comprising dibenzoylmethane and amide oil compounds and a compound that accepts the excited triplet level energy of said dibenzoylmethane(s)

Applicant/Assignee: L'OREAL

Application No.: 11/249398   Filing Date: 14/Oct/2005

Abstract:Topically applicable, improvedly photostabilized, photoprotective cosmetic/dermatological compositions contain (i) an effective UV-screening amount of at least one dibenzoylmethane sunscreen and an effective photostabilizing amount of (ii) at least one oil containing at least one amide structural unit and (iii) at least one compound accepting the excited triplet level energy of said at least one dibenzoylmethane sunscreen, formulated into (iv) a topically applicable, cosmetically/dermatologically acceptable support therefor.

Priority: FR20040052367 Applic. Date: 2004-10-19; US20040623034P Applic. Date: 2004-10-29

Inventor: CANDAU DIDIER [FR]

Title: Photostable photoprotective compositions comprising dibenzoylmethane and bis-resorcinyl triazine compounds and a compound that accepts the excited triplet level energy of said dibenzoylmethane(s)

Applicant/Assignee: L'OREAL

Application No.: 11/249521   Filing Date: 14/Oct/2005

Abstract:Topically applicable, improvedly photostabilized, photoprotective cosmetic/dermatological compositions contain (i) an effective UV-screening amount of at least one dibenzoylmethane sunscreen and an effective photostabilizing amount of (ii) at least one bis-resorcinyl triazine compound and (iii) at least one compound accepting the excited triplet level energy of said at least one dibenzoylmethane sunscreen, notably at least one 4-hydroxybenzylidenemalonate compound, 4-hydroxycinnamate compound, fluorene compound, piperidinol salt, or mixture thereof, formulated into (iv) a topically applicable, cosmetically/dermatologically acceptable support therefor.

Priority: FR20040052368 Applic. Date: 2004-10-19; US20040623580P Applic. Date: 2004-10-29

Inventor: CANDAU DIDIER [FR]

Title: Treatment of cancer by the use of anti fas antibody

Applicant/Assignee: FUSION ANTIBODIES LIMITED

Application No.: 10/514604   Filing Date: 02/Dec/2005

Abstract:The present invention provides a method of killing cancer cells and method of treatment of cancer comprising administration of a therapeutically effective amount of a) a specific binding member which binds to a cell death receptor or a nucleic acid encoding said binding member and (b) a chemotherapeutic agent. The binding member pereferably binds to a Fas receptor. Also described are medicaments for use in treating cancer.

Priority: GB20020011377 Applic. Date: 2002-05-17; GB20020014885 Applic. Date: 2002-06-27; WO2003GB02109 Applic. Date: 2003-05-16

Inventor: JOHNSTON PATRICK G [GB]; LONGLEY DANIEL [GB]

Title: Preparations for topical application and methods of delivering an active agent to a substrate

Applicant/Assignee:

Application No.: 11/248017   Filing Date: 11/Oct/2005

Abstract:A multi-layer dressing and controlled-release composition for topical application to a substrate include an emulsion and an active agent incorporated into the emulsion. The active agent includes a protein. A method of delivering the active agent to the substrate provides the emulsion and incorporates the active agent into the emulsion for delivery of the active agent to the substrate. Multi-layer dressings and methods particularly suited for management of wound exudate and effective debridement of wound eschar.

Priority: WO2004US35686 Applic. Date: 2004-10-27; US20030514709P Applic. Date: 2003-10-27

Inventor: BOTT RICHARD R [US]; BRANDSTADT KURT F [US]; KOLLAR CSILLA [US]; LANE THOMAS H [US]; LILES DONALD T [US]; SALDJENO MAE [US]; THOMAS XAVIER J [FR]; MURPHY KEVIN P [US]; SCHALAU GERALD K II [US]

Title: Surrogate markers of neuropathic pain

Applicant/Assignee:

Application No.: 10/784004   Filing Date: 20/Feb/2004

Abstract:The disclosure provides methods and compositions for the evaluation of neuropathic pain and neurotrophic or other activity of a drug or drug candidate. In the disclosed methods, expression of certain gene(s) in tissue extracts from skin biopsies serves as a proxy of a relevant endpoint.

Priority:

Inventor: SAH DINAH W Y [US]; CATE RICHARD [US]; EHRENFELS CHRISTIAN W [US]; SZAK SUZANNE [US]; BANDARU RAJASEKHAR [US]

Title: MN and hypoxia

Applicant/Assignee:

Application No.: 11/166997   Filing Date: 24/Jun/2005

Abstract:The MN/CA IX protein is identified herein as a hypoxia marker. The MN/CA9 gene promoter is characterized, and the location of the HIF-1 binding site within the MN/CA9 promoter is identified. Further, the hypoxia inducibility of the MN/CA9 gene and the uses of such inducibility are disclosed. In one aspect, the invention provides diagnostic/prognostic tools for determining the presence of hypoxia in a tissue in a vertebrate, preferably a human, and for measuring the relative degree of hypoxia in said vertebrate. In another aspect, the invention provides methods using tumor biopsies to predict the radioresistance of a preneoplastic/neoplastic tissue in a vertebrate subject, preferably a human patient, for diseases in which MN/CA IX levels can be used to indicate radiobiologically relevant tumor hypoxia. Such predictive methods can be used as an aid in patient therapy selection.

Priority: US20050649661P Applic. Date: 2005-02-03; US20040598941P Applic. Date: 2004-08-05; US20010341036P Applic. Date: 2001-12-13; US2002-319003 Applic. Date: 2002-12-13

Inventor: HARRIS ADRIAN L [GB]; RATCLIFFE PETER J [GB]; VORDERMARK DIRK [DE]

Title: Solubilizing systems for flavors and fragrances

Applicant/Assignee:

Application No.: 11/255032   Filing Date: 19/Oct/2005

Abstract:The present invention provides compositions and clear oil-in-water microemulsion containing up to 80% w/w of an oil, a surfactant system, a w/w oil/surfactant system ratio between 1 and 3, and a solubilizing-aid ingredient which is not a surfactant neither a VOC compound, the latter being present in an amount sufficient to ensure that the ratio oil/(surfactant +solubilizing aid) is comprised between 0.1 and 5. The present invention concerns also the articles and products associated the compositions and microemulsions, and the methods to manufacture them.

Priority: US20040620557P Applic. Date: 2004-10-20

Inventor: VLAD FLORIN J [US]; MOUNIER REMY [FR]; WONG KENNETH [CH]; DAUGERON AUDE [FR]; HERD THOMAS [US]

Title: Platelet-derived growth factor compositions and methods of use thereof

Applicant/Assignee: BIOMIMETIC THERAPEUTICS, INC

Application No.: 11/159533   Filing Date: 23/Jun/2005

Abstract:A method for promoting growth of bone, periodontium, ligament, or cartilage in a mammal by applying to the bone, periodontium, ligament, or cartilage a composition comprising platelet-derived growth factor at a concentration in the range of about 0.1 mg/mL to about 1.0 mg/mL in a pharmaceutically acceptable liquid carrier and a pharmaceutically-acceptable solid carrier.

Priority: US2004-965319 Applic. Date: 2004-10-14

Inventor: LYNCH SAMUEL E [US]

Title: Transepithelial delivery of peptides with incretin hormone activities

Applicant/Assignee: NITTO DENKO CORPORATION

Application No.: 11/219145   Filing Date: 02/Sep/2005

Abstract:Compositions and methods are disclosed for the treatment of diabetes and related diseases using peptides with incretin hormone activity. Preferably, the peptide with incretin hormone activity is GLP-1, exendin or an analog of GLP-1 or exendin. The peptides with incretin hormone activity are administered transepithelially using a transepithelial carrier peptide. The transepithelial peptide contains sufficient amino, guanidine or amidino groups to stimulate transepithelial delivery. In some embodiments, the transepithelial carrier and the peptide with incretin hormone activity are embedded in a pressure sensitive adhesive layer of a plaster or patch.

Priority: US20040620001P Applic. Date: 2004-10-19

Inventor: KITAURA CHIEKO [JP]; MINOMI KENJIRO [JP]; OKUBO KATSUYUKI [JP]; OKADA KEISAKU [JP]; KAGEHISA NATSUKO [JP]; KAMIYAMA MASASHI [JP]; HOU ZHENG [US]; LIU JIAN [US]; SONG YUCHENG [US]; YU LEI [US]

Title: Topically applicable pharmaceutical preparation

Applicant/Assignee: ALTANA PHARMA AG

Application No.: 10/515698   Filing Date: 11/Aug/2005

Abstract:A topical pharmaceutical preparation for administering a slightly soluble PDE 4 inhibitor that has a surprisingly good systemic bioavailability is described.

Priority: EP20020011830 Applic. Date: 2002-05-28; DE20021023828 Applic. Date: 2002-05-28; DE20031011613 Applic. Date: 2003-03-14; WO2003EP05524 Applic. Date: 2003-05-27

Inventor: BOLLE CHRISTINA [DE]; LINDER RUDOLF [DE]

Title: Human cDNA clones comprising polynucleotides encoding polypeptides and methods of their use

Applicant/Assignee:

Application No.: 10/948571   Filing Date: 24/Sep/2004

Abstract:The invention provides novel human full-length cDNA clones, novel polynucleotides, related polypeptides, related nucleic acid and polypeptide compositions, and related modulators, such as antibodies and small molecule modulators. The invention also provides methods to make and use these cDNA clones, polynucleotides, polypeptides, related compositions, and modulators. These methods include diagnostic, prophylactic and therapeutic applications. The compositions and methods of the invention are useful in treating proliferative disorders, e.g., cancers, and inflammatory, immune, bacterial, and viral disorders.

Priority: US20030505144P Applic. Date: 2003-09-24; US20040548191P Applic. Date: 2004-03-01; US20040589826P Applic. Date: 2004-07-22; US20040589788P Applic. Date: 2004-07-22

Inventor: WILLIAMS LEWIS T [US]; CHU KETING [US]; LEE ERNESTINE [US]; HESTIR KEVIN [US]; WONG JUSTIN [US]; DOBERSTEIN STEPHEN K [US]

Title: Compounds for enzyme inhibition

Applicant/Assignee: PROTEOLIX, INC

Application No.: 11/254541   Filing Date: 19/Oct/2005

Abstract:Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like and PGPH activities of the 20S proteasome can be selectively inhibited with the inventive compounds. The peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus, such as a detectable label. Along with therapeutic utilities, these peptide based compounds can be used in assays useful for screening, monitoring, diagnostic and/or dosing purposes.

Priority: US20040620573P Applic. Date: 2004-10-20; US20050674834P Applic. Date: 2005-04-26

Inventor: BENNETT MARK K [US]; BUCHHOLZ TONIA J [US]; DEMO SUSAN D [US]; LAIDIG GUY J [US]; LEWIS EVAN R [US]; SMYTH MARK S [US]

Title: Sustained release of active molecules from polymers topically applied to skin or hair

Applicant/Assignee:

Application No.: 11/259458   Filing Date: 26/Oct/2005

Abstract:The invention relates to a polymer for topical delivery of biologically active ingredients, the polymer comprising at least one moiety: U-B-A in which U represents a physiologically acceptable unit of an oligomer or polymer, A represents a biologically active component, and B represents one or more bond(s) linking A to U, which bond is capable of being disrupted by a biological, physical or chemical process occurring in or on skin.

Priority: US20040622583P Applic. Date: 2004-10-27

Inventor: GIACOMONI PAOLO [US]; GROSS RICHARD [US]; LACZYNSKI STEPHEN [US]

Title: Methods and devices for sustained in-vivo release of an active agent

Applicant/Assignee:

Application No.: 11/238144   Filing Date: 27/Sep/2005

Abstract:The present invention includes methods and devices for providing sustained in-vivo release of an active agent to a subject. In some aspects, such release may be achieved by reacting an active agent in-vivo with a depot forming agent in order to form a sustained release active agent depot inside the subject. The depot can then release the active agent over a sustained period of time.

Priority: US20040623150P Applic. Date: 2004-10-27; US2005-238104 Applic. Date: 2005-09-27

Inventor: HIGUCHI JOHN [US]; LI S K [US]; HIGUCHI WILLIAM I [US]; HASTINGS MATTHEW S [US]

Title: Pharmaceutical composition for topical application

Applicant/Assignee: FOAMIX LTD

Application No.: 11/294318   Filing Date: 05/Dec/2005

Abstract:A pharmaceutical or cosmetic carrier or composition for topical application characterized by rheological properties which render the carrier or composition semi-solid at rest and a liquid upon application of shear forces thereto. The composition or carrier are prepared by mixing 1-25 percent of a solidifying agent and 75-99 percent of a hydrophobic solvent, by weight, wherein at least one of them has therapeutic or cosmetic benefits, in the presence or absence of a biologically active substance.

Priority: US2003-392071 Applic. Date: 2003-03-19; US2000-653267 Applic. Date: 2000-08-31; US20000216162P Applic. Date: 2000-07-03; WO2001IL00025 Applic. Date: 2001-01-10; IL20000133968 Applic. Date: 2000-01-10; IL20000133969 Applic. Date: 2000-01-10; IL20000137051 Applic. Date: 2000-06-27; IL20000137052 Applic. Date: 2000-06-27; IL20020150644 Applic. Date: 2002-07-17; US2000-526509 Applic. Date: 2000-03-16

Inventor: EINI MEIR [IL]; TAMARKIN DOV [IL]

Title: Hormone-containing transdermal therapeutic system with an active substance reservoir based on vinylacetate-vinylpyrrolidone copolymer with improved cohesion

Applicant/Assignee:

Application No.: 10/507628   Filing Date: 07/Oct/2005

Abstract:A transdermal therapeutic system in patch form for the controlled delivery of active substances to the human or animal skin comprises a backing layer, an active substance-containing reservoir attached thereto and a detachable protective layer, is characterized in that the active substance-containing reservoir contains as main components thereof at least one film former as well as at least one polymer which prevents or suppresses the crystallisation of the active substance or active substances.

Priority: DE20021011832 Applic. Date: 2002-03-16; WO2003EP02521 Applic. Date: 2003-03-12

Inventor: MECONI REINHOLD [DE]; KLEIN ROBERT-PETER [DE]; KLEIN URSULA H [DE]; SEIBERTZ FRANK [DE]; BECKER FRANZ-JOSEF [DE]; COTTE URSULA [DE]

Title: Composition for treatment of topical infection and methods of making and using same

Applicant/Assignee:

Application No.: 11/218872   Filing Date: 02/Sep/2005

Abstract:Compositions and methods for the prevention and treatment of topical infections using essential oil or extract from Minthostachys mollis (Peperina) or other herbs of the family Lamiaceae, or any combination of its individual chemical components and an acceptable carrier are disclosed.

Priority: US20040606679P Applic. Date: 2004-09-02

Inventor: SIVAK HANNAH N [US]; IGLESIAS ALBERTO A [AR]; BALLICORA MIGUEL A [US]

Title: Method for determining the homeostasis of hairy skin

Applicant/Assignee:

Application No.: 11/158209   Filing Date: 20/Jun/2005

Abstract:The invention relates to a method for determining the homeostasis of hairy skin in vitro, to test kits and biochips for determining markers of hairy skin, in addition to the use of proteins, mRNA molecules or fragments thereof as markers of hairy skin. The invention also relates to a test method for detecting the effectiveness of cosmetic or pharmaceutical active substances for treating hairy skin in addition to a screening method for identifying cosmetic or pharmaceutical active substances for treating hairy skin and to a method for producing a cosmetic or pharmaceutical preparation for treating hairy skin.

Priority: DE20021060931 Applic. Date: 2002-12-20; WO2003EP14070 Applic. Date: 2003-12-11

Inventor: PETERSOHN DIRK [DE]; SCHLOTMANN KORDULA [DE]; GASSENMEIER THOMAS [DE]; HOLTKOETTER OLAF [DE]; CONRADT MARCUS [DE]; HOFMANN KAY [DE]

Title: Topical anti-microbial compositions

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY ARCH CHEMICALS, INC

Application No.: 11/299195   Filing Date: 08/Dec/2005

Abstract:Disclosed are topical compositions for the treatment of microbial infections on the skin or scalp which include a polyvalent metal salt of pyrithione and include a metal ion source. Also disclosed are methods for treating microbial infections of the skin or scalp using such compositions.

Priority: US2000-599624 Applic. Date: 2000-06-22

Inventor: GAVIN DAVID F [US]; MARCHETTA ANTHONY R [US]; NELSON JOHN D JR [US]; POLSON GEORGE [US]; SCHWARTZ JAMES R [US]; TURLEY PATRICIA A [US]

Title: Combination

Applicant/Assignee:

Application No.: 11/295928   Filing Date: 07/Dec/2005

Abstract:The present invention relates to a combination, especially a pharmaceutical composition, comprising as active ingredients (i) an AT1-receptor antagonist or a pharmaceutically acceptable salt thereof

(ii) (a) an insulin secretion enhancer or a pharmaceutically acceptable salt thereof or (b) an insulin sensitizer or a pharmaceutically acceptable salt thereof

and, in case of a pharmaceutical composition, a pharmaceutically acceptable carrier.

Priority: US2003-362340 Applic. Date: 2003-06-16; WO2001EP09587 Applic. Date: 2001-08-20; US20000327553P Applic. Date: 2000-08-22

Inventor: ALLISON MALCOLM [CH]; GATLIN MARJORIE R [US]

Title: Inhibitors of the fatty acid oxidation for the prophylaxis and/or the treatment of chronic and/or atopic skin diseases

Applicant/Assignee:

Application No.: 10/528308   Filing Date: 12/Sep/2005

Abstract:The invention relates to a method of preventing and/or treating a chronic and/or an atopic skin disease by administering an inhibitor of fatty acid oxidation to a patient in a pharmacologically effective amount. Furthermore, the invention relates to the use of at least one inhibitor of fatty acid oxidation for the preparation of a pharmaceutical composition for the prophylaxis and/or treatment of a chronic and/or an atopic skin disease.

Priority: US20020411962P Applic. Date: 2002-09-19; WO2003EP10397 Applic. Date: 2003-09-18

Inventor: NIELAND JOHN [DE]; GANDER-MEISTERNST IRENE [DE]; ROHRBACH MARTIN [DE]; NAVE BARBARA [DE]

Title: Processes for modifying textiles using ionic liquids

Applicant/Assignee:

Application No.: 11/263391   Filing Date: 31/Oct/2005

Abstract:Processes for modifying a textile to improve its performance which comprise the steps of a) contacting a textile comprising fibers with a treating composition comprising an ionic liquid under conditions sufficient to modify at least surfaces of the fibers, thereby provide a performance improvement to treated textile

b) optionally, contacting a textile comprising fibers with a composition comprising a benefit agent

and c) at least partially removing the treating composition from the textile. In specific embodiments, the surface modification comprises a partial dissolution of at least one outer layer of the fibers and/or crystal structure change in at least surfaces of the fibers. The surface modification can impart improvements to the textile or allow embedding or attachment of a benefit agent in the fibers.

Priority: US20040624053P Applic. Date: 2004-11-01

Inventor: PRICE KENNETH N [US]; WANG JIPING [US]; WASHINGTON NODIE M [US]; HECHT STACIE E [US]; MIRACLE GREGORY S [US]; SCHEIBEL JEFFREY J [US]

Title: Multiphase cleaning compositions having ionic liquid phase

Applicant/Assignee:

Application No.: 11/263392   Filing Date: 31/Oct/2005

Abstract:A multiphase cleaning composition comprises a first phase and a second ionic liquid phase, wherein the second phase is substantially immiscible with the first phase. The first phase may comprise, for example, an aqueous phase or a silicone solvent system. Methods of cleaning a soiled surface comprise contacting a soiled surface with a multiphase wash liquor including a first phase and a second ionic liquid phase, wherein the second phase is substantially immiscible with the first phase, and removing soils from the surface.

Priority: US20040624127P Applic. Date: 2004-11-01

Inventor: HECHT STACIE E [US]; PRICE KENNETH N [US]; BERGER PATRICIA S [US]; FOLEY PETER R [US]; HUTTON HOWARD D III [US]; SHOWELL MICHAEL S [US]; GARDNER ROBB R [US]; NIEHOFF RAYMOND L [US]; SEDDON KENNETH R [GB]; GUNARATNE HARAMBAGE QUINTAS N [GB]; EARLE MARTYN [GB]

Title: Cd26-based therapies for cancers and immune disease

Applicant/Assignee:

Application No.: 10/514738   Filing Date: 19/Oct/2005

Abstract:Therapeutic methods comprising administering a composition comprising CD26 thereof in conjunction with chemotherapeutic agents or radiotherapeutic agents for the prevention and treatment of cancers are provided. Also provided are methods for potentiating immune responses comprising administering a composition comprising CD26.

Priority: US20020381606P Applic. Date: 2002-05-17; WO2003US15499 Applic. Date: 2003-05-15

Inventor: DANG NAM H [US]; MORIMOTO CHIKAO [JP]

Title: Device for bio-affinity material

Applicant/Assignee: GLYCOREX TRANSPLANTATION AB

Application No.: 11/304364   Filing Date: 15/Dec/2005

Abstract:Bio-affinity material containing at least one biologically active saccharide which is covalently bound via at least one spacer to a cross-linked matrix and that the material is autoclaved. Apparatus for contacting body fluids with the bio-affinity material is disclosed.

Priority: US2002-114314 Applic. Date: 2002-04-03; US1996-091486 Applic. Date: 1996-12-23; US2000-722241 Applic. Date: 2000-11-27; WO2001SE00241 Applic. Date: 2001-02-07

Inventor: NILSSON KURT G L [SE]

Title: Cosmetic and/or dermatological preparation comprising 2,3-dibenzylbutyrolactones

Applicant/Assignee:

Application No.: 10/515000   Filing Date: 26/Sep/2005

Abstract:Cosmetic and/or dermatological preparation containing one or more 2,3-dibenzylbutyrolactone derivatives and/or their glycosides besides optionally additional cosmetic and/or dermatological active ingredients, auxiliary agents, and additives.

Priority: DE20021023486 Applic. Date: 2002-05-27; WO2003EP05347 Applic. Date: 2003-05-22

Inventor: STAB FRANZ [DE]; WOLBER RAINER [DE]; BLATT THOMAS [DE]; KOLBE LUDGER [DE]; MUNDT CLAUDIA [DE]; GALLIANT STEFAN [DE]; VENZKE KIRSTEN [DE]; DIECK KAREN T [DE]; BREITENBACH UTE [DE]

Title: Personal care compositions and concentrates for making the same

Applicant/Assignee: LONZA INC

Application No.: 11/112479   Filing Date: 22/Apr/2005

Abstract:The present invention relates to color stable personal care compositions that provide anti-oxidiation, moisturization, and/or prevent biodegradation in personal care formulations. These compositions contain erythorbic acid or a salt thereof, caffeic acid or a salt thereof, delta-gluconolactone, or a mixture thereof. The present invention further relates to methods of moisturizing skin with erythorbic acid or a salt thereof, or delta-gluconolactone. The present invention also relates to concentrates of active ingredients preloaded with a sufficient amount of an anti-oxidation, moisturizing and/or biodegradation prevention agent so that when it is diluted for use, the final formulation includes an anti-oxidation, moisturizing and/or biodegradation prevention effective amount of the anti-oxidation, moisturizing, and/or biodegradation prevention agent.

Priority: US20040565003P Applic. Date: 2004-04-23

Inventor: LUTZ PATRICK J [US]; WINTERS KRISTY A [US]; DUNN KELLY A [US]; GUTH JACOB [US]

Title: Hydroxide-releasing agents as skin permeation enhancers

Applicant/Assignee:

Application No.: 11/303614   Filing Date: 16/Dec/2005

Abstract:A method is provided for increasing the permeability of skin or mucosal tissue to topically or transdermally administered pharmacologically or cosmeceutically active agents. The method involves use of a specified amount of a hydroxide-releasing agent, the amount optimized to increase the flux of the active agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. Topically applied formulations and drug delivery devices employing hydroxide-releasing agents as permeation enhancers are provided as well.

Priority: US2003-371352 Applic. Date: 2003-02-19; US2000-738410 Applic. Date: 2000-12-14; US2000-569889 Applic. Date: 2000-05-11; US1999-465098 Applic. Date: 1999-12-16

Inventor: LUO ERIC C [US]; JACOBSON ERIC C [US]; HSU TSUNG-MIN [US]

Title: Sustained-release composition process for producing the same and preparation thereof

Applicant/Assignee:

Application No.: 10/516122   Filing Date: 22/Dec/2005

Abstract:The present invention provides a sustained-release composition by which a sustained-release effect can be obtained for a long time when injecting microparticles of the composition in an amount that can be subcutaneously or intramuscularly injected to a human with ease and without pain. The composition comprises porous hydroxyapatite microparticles having pores embolized by filling the pores in the microparticles with a biologically active drug, a human serum protein, and a mucopolysaccharide, and adding a divalent metal ion. Alternatively, the composition comprises porous hydroxyapatite microparticles having pores embolized in the outer layer by filling the pores in the microparticles with a biologically active drug, a human serum protein, and a water-soluble calcium salt one after another or at one time, and then adding sodium carbonate, sodium hydrogen carbonate, or an aqueous carbonate ion solution.

Priority: JP20020179788 Applic. Date: 2002-06-20; JP20020374173 Applic. Date: 2002-12-25; WO2003JP07251 Applic. Date: 2003-06-09

Inventor: MIZUSHIMA YUTAKA [JP]; TAKAGI YUKIE [JP]; HAGI TOMOMI [JP]; IKOMA TOSHIYUKI [JP]

Title: Skin cosmetics

Applicant/Assignee: TAKASAGO INTERNATIONAL CORPORATION

Application No.: 11/302363   Filing Date: 14/Dec/2005

Abstract:Skin cosmetics which are excellent in moistness and persistency of moisture-keeping effect, show light sense of touch when used and have excellent periodical stability. In addition, there are provided skin cosmetics which do not cause stickiness after their use, are excellent in rough skin improving and preventing effects, wrinkle preventing and improving effects, dinginess improving effect and the like, and also have an effect in providing the skin with smoothness and liveliness. Also, in the case of skin cleansing compositions, they exert such effects that they can provide the skin with liveliness and moistness after washing and can effectively remove fishy and ammonia smells or the like filthy smell adhered to the hand, the skin and the like. A skin cosmetic characterized in that it contains (A) at least one substance selected from seed extracts and seed hull extracts of a plant belonging to the genus Carya of the family Juglandaceae in an amount of from 0.00005 to 2% by weight as solid matter, and (B) an additive agent.

Priority: JP20020348360 Applic. Date: 2002-11-29; JP20020370231 Applic. Date: 2002-12-20; JP20020370238 Applic. Date: 2002-12-20; US2003-724354 Applic. Date: 2003-12-01

Inventor: KAWADA IZUMI [JP]; ISHIDA MISAKI [JP]

Title: Benefit agent delivery system comprising ionic liquid

Applicant/Assignee:

Application No.: 11/263389   Filing Date: 31/Oct/2005

Abstract:A benefit agent delivery system comprises a benefit agent, wherein the benefit agent is protected or stabilized by an ionic liquid and wherein the benefit agent is releasable from the system to provide the benefit. For example, the ionic liquid may be physically associated with the benefit agent, such as by coating, encapsulation, or co-crystallization, or may be chemically associated with the benefit agent, such as by chemical reaction. The benefit agent delivery system may be in the form of a concentrate, in a product formulation, or on or associated with a substrate or package. Detergent compositions may include the benefit agent delivery system. Methods for cleaning a soiled substrate comprise contacting a soiled substrate with such a composition, and removing soil from the substrate.

Priority: US20040624051P Applic. Date: 2004-11-01

Inventor: PRICE KENNETH N [US]; HECHT STACIE E [US]; JORDAN GLENN T IV [US]; KENNEALLY COREY J [US]; AOUAD YOUSEF G [US]; SHOWELL MICHAEL S [US]; MIRACLE GREGORY S [US]

Title: Multi-phase personal cleansing compositions comprising a lathering cleansing phase and a non-lathering structured aqueous phase

Applicant/Assignee:

Application No.: 11/263749   Filing Date: 01/Nov/2005

Abstract:The present invention relates to multi-phase personal cleansing compositions containing a lathering cleansing phase and a separate non-lathering structured aqueous phase wherein the two phases are packaged in physical contact while remaining stable over time.

Priority: US2004-001796 Applic. Date: 2004-12-02; US20030532798P Applic. Date: 2003-12-24; US20040576199P Applic. Date: 2004-06-02

Inventor: WEI KARL S [US]; SMITH EDWARD D III [US]

Title: Aqueous cleansing composition with gel flakes

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 10/978511   Filing Date: 01/Nov/2004

Abstract:An aqueous liquid cleansing and optional moisturizing composition is provided having a surfactant

a thickening or structuring agent, and gel flakes containing in a preferred embodiment plate-like particles. The gel flakes provide unique aesthetics to the cleansing composition. In another preferred embodiment the inventive cleansing composition includes a free skin conditioning agent having a weight average particle size in the range about 1 to about 500 microns or a clear suspending surfactant system.

Priority:

Inventor: PEREIRA DANIEL [US]

Title: Combination therapy using an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist to minimize the side effects associated with glucocorticoid receptor agonist therapy

Applicant/Assignee:

Application No.: 11/246814   Filing Date: 07/Oct/2005

Abstract:Combination therapy comprising the administration of an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist for treating some forms of cancer, diseases and disorders having inflammation as a component, and to minimize the side effects associated with glucorticoid receptor agonist therapy.

Priority: DK20030000570 Applic. Date: 2003-04-11; DK20030000566 Applic. Date: 2003-04-11; DK20030000565 Applic. Date: 2003-04-11; DK20030000569 Applic. Date: 2003-04-11; DK20030000567 Applic. Date: 2003-04-11; DK20030000571 Applic. Date: 2003-04-11; DK20030000776 Applic. Date: 2003-05-22; DK20030000777 Applic. Date: 2003-05-22; DK20030000972 Applic. Date: 2003-06-27; DK20030000990 Applic. Date: 2003-06-30; DK20030000778 Applic. Date: 2003-05-22; DK20030000989 Applic. Date: 2003-06-30; DK20030000988 Applic. Date: 2003-06-30; DK20030000998 Applic. Date: 2003-07-02; DK20030001910 Applic. Date: 2003-12-22; DK20040000009 Applic. Date: 2004-01-06; DK20030000568 Applic. Date: 2003-04-11; WO2004DK00248 Applic. Date: 2004-04-06; US20030467284P Applic. Date: 2003-05-02; US20030467453P Applic. Date: 2003-05-02; US20030467363P Applic. Date: 2003-05-02; US20030467362P Applic. Date: 2003-05-02; US20030467443P Applic. Date: 2003-05-02; US20030475157P Applic. Date: 2003-06-02; US20030475195P Applic. Date: 2003-06-02; US20030486078P Applic. Date: 2003-07-10; US20030486098P Applic. Date: 2003-07-10; US20030486094P Applic. Date: 2003-07-10; US20030486095P Applic. Date: 2003-07-10; US20030486097P Applic. Date: 2003-07-10; US20040537099P Applic. Date: 2004-01-16

Inventor: KAMPEN GITA CAMILLA T [DK]; ANDERSEN HENRIK S [DK]

Title: NK1 antagonists

Applicant/Assignee:

Application No.: 11/300848   Filing Date: 15/Dec/2005

Abstract:Disclosed are NK1 antagonists having the formula: Also disclosed are methods for treating a number of physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough, using the compounds of formula (I).

Priority: US2003-612176 Applic. Date: 2003-07-02; US20020393708P Applic. Date: 2002-07-03

Inventor: SHIH NENG-YANG [US]; WANG STEVEN [US]; REICHARD GREGORY [US]; XIAO DONG [US]; WANG CHENG [US]

Title: Method of treating extracellular matrix

Applicant/Assignee: SYNERON MEDICAL LTD

Application No.: 10/980822   Filing Date: 04/Nov/2004

Abstract:A method for treating skin tissue or extracellular matrix in a body region. A precursor of a photosensitive compound is introduced into the body region. One or more enzymes converting the precursor to the photosensitive compound are then introduced into the body region so as to convert the precursor to the photosensitive compound in the extracellular matrix of the body region.

Priority:

Inventor: ECKHOUSE SIMON [IL]; KREINDEL MICHAEL [IL]; SHILOH JOSEPH [IL]

Title: Ultrasonic apparatus and method for treating obesity or fat-deposits or for delivering cosmetic or other bodily therapy

Applicant/Assignee:

Application No.: 11/262452   Filing Date: 27/Oct/2005

Abstract:Obesity or fat deposits are treated with ultrasound. In one embodiment, a waveguide-based apparatus and method are disclosed for applying ultrasound to a treatment-subject for the purpose of providing treatment or therapy for obesity, fat-deposits, cosmetic benefit or other bodily therapy tasks. In another embodiment, a novel apparatus and method are disclosed for providing at least one such treatment or therapy using a liquid-based waveguide. In yet another embodiment, a wearable apparatus is disclosed that incorporates a waveguide of the invention. Any of the embodiments has application to hospital use, clinical use or home use, for example, and the place of use will likely be determined by which treatment mechanism is employed and at what power-level.

Priority: US20040623535P Applic. Date: 2004-10-28

Inventor: TOSAYA CAROL A [US]; BLUMENFELD LEE [US]; SLIWA JOHN W JR [US]

Title: Aesthetic thermal sculpting of skin

Applicant/Assignee: APSARA MEDICAL CORPORATION

Application No.: 11/298420   Filing Date: 09/Dec/2005

Abstract:Method, system and apparatus for carrying out a controlled heating of dermis to achieve a percentage of linear collagen shrinkage. Implants are employed which preferably are configured as a thermal barrier defining support an outwardly disposed support surface of which carries one or more heater segments. Located along heating channels at the interface between dermis and next adjacent subcutaneous tissue, the structure protects the latter from thermally induced damage while directing heat energy into the former.

Priority: US2003-733970 Applic. Date: 2003-12-11; US20050677955P Applic. Date: 2005-05-05

Inventor: EGGERS PHILIP E [US]; CAMPBELL-WHITE ANNETTE [US]; TOTH BRYANT A [US]

Title: Novel amine, amide, sulphonamide and carbamate derivatives of benzalmalonic salts and photoprotective cosmetic compositions comprised thereof

Applicant/Assignee: L'OREAL

Application No.: 11/315249   Filing Date: 23/Dec/2005

Abstract:Stable, topically applicable cosmetic/dermatological sunscreen compositions, well suited for the UV-photoprotection of human skin/keratinous materials, contain a thus effective amount of at least one novel amine, amide, sulphonamide or carbamate substituted benzalmalonic salt compound.

Priority: FR20030002561 Applic. Date: 2003-03-03; US2004-787759 Applic. Date: 2004-02-27; US20030483652P Applic. Date: 2003-07-01

Inventor: RICHARD HERVE [FR]; LUPPI BERNADETTE [FR]

Title: Composition intended to be applied to the skin and the integuments

Applicant/Assignee:

Application No.: 10/529872   Filing Date: 12/Oct/2005

Abstract:The present invention relates to a composition intended to be applied to the skin, the lips and/or the integuments, comprising, in a physiologically acceptable medium, at least one composite pigment comprising:-a mineral core,-at least one organic pigment at least partially covering the mineral core,and-at least one binder for fixing the organic pigment onto the mineral core.

Priority: FR20020012215 Applic. Date: 2002-10-02; US20020428723P Applic. Date: 2002-11-25; WO2003IB04306 Applic. Date: 2003-10-01

Inventor: DUMOUSSEAUX CHRISTOPHE [JP]

Title: Personal care composition containing a non-guar galactomannan polymer derivative

Applicant/Assignee:

Application No.: 11/264645   Filing Date: 01/Nov/2005

Abstract:Personal care compositions comprise (a) from about from about 5 wt. % to about 35 wt. % of a detersive surfactant

(b) at least about 0.05 wt. % of a galactomannan polymer derivative having a mannose to galactose ratio of greater than 2:1 on a monomer to monomer basis, the galactomannan polymer derivative selected from a cationic galactomannan polymer derivative and an amphoteric galactomannan polymer derivative having a net positive charge, the galactomannan polymer derivative having a molecular weight from about 1,000 to about 10,000,000 and a cationic charge density from about 0.9 meq/g to about 7 meq/g

and (c) at least about 20 wt. % of an aqueous carrier. Methods of treating hair or skin comprise applying the personal care composition as described above to the hair or skin and rinsing the hair or skin.

Priority: US20040625511P Applic. Date: 2004-11-05

Inventor: STAUDIGEL JAMES A [US]; PEFFLY MARJORIE M [US]; PLIEGO SALVADOR [US]; DECKNER GEORGE E [US]

Title: Photoprotective orally administrable composition for skin

Applicant/Assignee:

Application No.: 11/314043   Filing Date: 20/Dec/2005

Abstract:An orally administrable composition for the photoprotection of the skin which comprises a photoprotecting effective amount of i) at least one probiotic lactic acid bacterium or a culture supernatant thereof, and ii) at least one yeast, included into an orally acceptable carrier.

Priority: EP20020075701 Applic. Date: 2002-02-21; US2003-695833 Applic. Date: 2003-10-30; US2004-504906 Applic. Date: 2004-08-18; WO2003EP01686 Applic. Date: 2003-02-18

Inventor: BRETON LIONEL [FR]; BUREAU-FRANZ ISABELLE [CH]; GUENICHE AUDREY [FR]

Title: Enzymetic hydrolysate of algae and method for preparing the same

Applicant/Assignee: TAIYEN BIOTECH CO. LTD

Application No.: 11/041692   Filing Date: 24/Jan/2005

Abstract:An enzymatic hydrolysate of algae and a method for preparing the same are disclosed. After rehydrating dry algae, an insoluble pellet is digested by using a specific enzymatic reaction condition, so as to produce the soluble and bioactive enzymatic hydrolysate of algae. The enzymatic hydrolysate of algae, which comprises a mixture of polysaccharides and polypeptides, can promote a growth of skin cells cultured in vitro and be formulated in cosmetic, food or skin external agent compositions.

Priority: TW20040134535 Applic. Date: 2004-11-11

Inventor: CHEN PO-HAN [TW]; HUANG MING-HUNG [TW]

Title: Liquid, gas and/or vapor phase delivery systems

Applicant/Assignee: BYRD-WALSH, LLC

Application No.: 10/986101   Filing Date: 10/Nov/2004

Abstract:This invention relates generally to liquid, gas and/or vapor phase delivery systems and, more particularly, to delivery systems that incorporate at least one layer, film and/or capsule that produces a liquid, gas and/or vapor phase compound or compounds for use therein.

Priority:

Inventor: CANTWELL EVELYNA D [US]; CANTWELL JOHN W [US]; LYUBLINSKI EFIM Y [US]; VAKS YEFIM [US]

Title: Sterile preparations and compositions including stinging capsules and methods of producing and using same

Applicant/Assignee: NANOCYTE INC

Application No.: 10/981522   Filing Date: 05/Nov/2004

Abstract:A sterile stinging capsule preparation and methods of producing and using same are provided.

Priority: US2004-868802 Applic. Date: 2004-06-17; US2003-406202 Applic. Date: 2003-04-04; US2001-963672 Applic. Date: 2001-09-27; US20000235910P Applic. Date: 2000-09-28

Inventor: LOTAN TAMAR [IL]

Title: Device and method for delivering an oral care agent

Applicant/Assignee: RANIR/DCP CORPORATION

Application No.: 10/985709   Filing Date: 10/Nov/2004

Abstract:An oral care agent delivery device is provided which comprises a permanently deformable backing layer, an oral care layer, and a non-woven binding material with a first part that is substantially invested in the oral care layer and a second part that is substantially invested in the backing layer. The device is sized to fit over a plurality of teeth in an upper or lower dental arch of a subject. The oral care layer comprises at least one oral care agent and at least one hydrophilic polymer. When hydrated, the oral care layer has an adhesiveness relative to the surface of a user's teeth that is sufficient to retain the device on the user's teeth when placed thereon. The device can also have an oral care agent which is activated on hydration of the oral care layer, or an oral care layer which releases the oral care agent over time.

Priority:

Inventor: FAASSE ADRIAN L [US]; KLEMM STEVEN R [US]; GROENEWEG GLEN E [US]; THELEN ALAN G [US]

Title: Anti-allergic complex molecules

Applicant/Assignee: RAMOT AT TEL AVIV UNIVERSITY LTD

Application No.: 11/214588   Filing Date: 29/Aug/2005

Abstract:The present invention discloses novel anti-allergic complex molecules, and in particular, peptidic or peptidomimetic molecules, that includes a first part which is competent for cell penetration and a second part which is able to reduce or abolish mast cell degranulation, in particular to reduce or abolish allergy mediators, including histamine secretion from mast cells and protein kinase activation, wherein the first part is connected to the second part via a linker or a direct bond that creates a conformational constraint by forming a bend or turn.

Priority: IL20000140473 Applic. Date: 2000-12-21; US2003-465826 Applic. Date: 2003-06-20; WO2001IL01186 Applic. Date: 2001-12-20

Inventor: EISENBERG RONIT [IL]; RAZ TAMAR [IL]

Title: Topical application of ivermectin for the treatment of dermatological conditions/afflictions

Applicant/Assignee: GALDERMA S.A

Application No.: 11/255910   Filing Date: 24/Oct/2005

Abstract:Dermatological conditions/afflictions such as rosacea, common acne, seborrheic dermatitis, perioral dermatitis, acneform rashes, transient acantholytic dermatosis, and acne necrotica miliaris, most notably rosacea, are treated by topically applying onto the affected skin area of an individual in need of such treatment, a topical pharmaceutical composition which comprises a thus effective amount of ivermectin.

Priority: FR20030005048 Applic. Date: 2003-04-24; WO2004EP04950 Applic. Date: 2004-04-22; US20030468994P Applic. Date: 2003-05-09

Inventor: MANETTA VINCENT [US]; WATKINS GARY R [US]

Title: Synergistic combinations of macrolide t-cell modulator or immunosuppressant and a retinoid

Applicant/Assignee:

Application No.: 10/550358   Filing Date: 23/Sep/2005

Abstract:Additive or synergistic combinations of a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro-33-desoxyascomycin and a retinoid, such as etretinate, isotretinoin or tazarotene, optionally with a further pharmaceutically active agent, especially an antibacterial, are provided, which are useful in particular in the treatment of dermatological diseases such as eczema, atopic dermatitis, acne, psoriasis, skin aging, sun damage, post-peel erythema and stretch marks.

Priority: GB20030007864 Applic. Date: 2003-04-04; WO2004EP03511 Applic. Date: 2004-04-02

Inventor: GRASSBERGER MAXIMILIAN [AT]; HIRSCH STEFAN [DE]; MAYER FRIEDRICH K [CH]; MEINGASSNER JOSEF G [AT]; PAUL CARLE [FR]; SEKKAT NABILA [CH]; STUTZ ANTON [AT]

Title: Mousse composition

Applicant/Assignee: CONNETICS AUSTRALIA PTY LTD

Application No.: 11/303298   Filing Date: 16/Dec/2005

Abstract:A pharmaceutical aerosol foam composition including an effective amount of a pharmaceutically active ingredient

an occlusive agent

an aqueous solvent

and an organic cosolvent, the pharmaceutically active ingredient being insoluble in both water and the occlusive agent

the occlusive agent being present in an amount sufficient to form an occlusive layer on the skin, in use.

Priority: AU1998PP05831 Applic. Date: 1998-09-11; US2004-766202 Applic. Date: 2004-01-27; US2001-719662 Applic. Date: 2001-01-30; WO1999AU00735 Applic. Date: 1999-09-08

Inventor: ABRAM ALBERT Z [AU]

Title: Photostable photoprotective compositions comprising dibenzoylmethane and arylalkyl benzoate compounds and a compound that accepts the excited triplet level energy of said dibenzoylmethane(s)

Applicant/Assignee: L'OREAL

Application No.: 11/249304   Filing Date: 14/Oct/2005

Abstract:Topically applicable, improvedly photostabilized, photoprotective cosmetic/dermatological compositions contain (i) an effective UV-screening amount of at least one dibenzoylmethane sunscreen and an effective photostabilizing amount of (ii) at least one arylalkyl benzoate compound and (iii) at least one compound accepting the excited triplet level energy of said at least one dibenzoylmethane sunscreen, formulated into (iv) a topically applicable, cosmetically/dermatologically acceptable support therefor.

Priority: FR20040052370 Applic. Date: 2004-10-19; US20040623038P Applic. Date: 2004-10-29

Inventor: CANDAU DIDIER [FR]

Title: Whitening agent, skin preparation for external use and cosmetic

Applicant/Assignee: NICHIREI BIOSCIENCE INC NICHIREI BIOSCIENCES INC

Application No.: 10/537958   Filing Date: 22/Jul/2005

Abstract:The invention relates to a whitening agent that makes effective use of camu camu seeds, which have conventionally been discarded, and that has high safety and whitening effect useful in cosmetics and the like, as well as skin preparations for external use and cosmetics containing the whitening agent. The whitening agent of the present invention contains camu camu seed extract as an active component, and the skin preparations for external use and cosmetics of the present invention contain the whitening agent.

Priority: JP20020362507 Applic. Date: 2002-12-13; WO2003JP15656 Applic. Date: 2003-12-08

Inventor: NAGAMINE KENICHI [JP]; HAYASHI MIKI [JP]; YAMASAKI KAORI [JP]

Title: Compound, process for producing the same and use thereof

Applicant/Assignee: NICHIREI BIOSCIENCES INC

Application No.: 10/543801   Filing Date: 29/Jul/2005

Abstract:The compound of the present invention is a component originated from a natural material, camu camu (Myrciaria dubia), has strong antioxidative activity and stable whitening effect, and is represented by the formula (1). The antioxidant, whitening agent, skin preparation for external use, cosmetics, and food of the present invention are characterized by the inclusion of the compound represented by the formula (1).

Priority: JP20030042486 Applic. Date: 2003-02-20; WO2003JP16544 Applic. Date: 2003-12-24

Inventor: NAGAMINE KENICHI [JP]; HAYASHI MIKI [JP]; YAMASAKI KAORI [JP]

Title: Compositions for treating infected skin and mucous membrane comprising an anti-microbial agent and an essential oil

Applicant/Assignee: J.P.M.E.D. LTD

Application No.: 10/535961   Filing Date: 20/May/2005

Abstract:The invention provides a composition of matter for treating infected skin and mucousal membranes, said composition comprising at least one anti-microbial drug

and at least one essential oil, in combination with a substantially, alcohol-free carrier system, said carrier being selected from a liquid carrier or a semi-solid carrier, said carrier system being selected from isotonic system and a moderately hypertonic system.

Priority: IL20020152993 Applic. Date: 2002-11-21; IL20030158901 Applic. Date: 2003-11-17; WO2003IL00980 Applic. Date: 2003-11-19

Inventor: FRIEDMAN DORON I [IL]

Title: Skin care formulation containing whole egg powder

Applicant/Assignee:

Application No.: 11/328399   Filing Date: 10/Jan/2006

Abstract:A skin care formulation is provided, the formulation comprises dehydrated whole egg, at least one emollient substance and at least one humectant substance and the dehydrated whole egg is hydrated during the manufacturing process.

Priority: US2005-294838 Applic. Date: 2005-12-07; US2002-260344 Applic. Date: 2002-10-01; US2002-039793 Applic. Date: 2002-01-08

Inventor: MARENICK MICHAEL [US]; ALBRIGHT ROBERT L [US]

Title: Systems and methods for treating warts

Applicant/Assignee:

Application No.: 11/271020   Filing Date: 10/Nov/2005

Abstract:The present invention is drawn to systems and methods for treating warts. The system can comprise a wart treatment formulation comprising a substance for treating warts and a cavity patch comprising an open cavity being configured to become a closed cavity upon application and adherence to a skin surface. The closed cavity can be configured to contain the wart treatment formulation.

Priority: US20040627555P Applic. Date: 2004-11-12

Inventor: ZHANG JIE [US]; WARNER KEVIN S [US]

Title: Transdermal therapeutic system

Applicant/Assignee:

Application No.: 11/087754   Filing Date: 24/Mar/2005

Abstract:The invention concerns a transdermal therapeutic system containing ergoline derivatives, preferably lisuride, with a stabilized ergoline compound. Stabilization of the oxidation sensitive ergoline combination is done through a combination of at least one fat-soluble, radical-trapping antioxidant, preferably Di-tert.-butylmethylphenols, Di-tert.-butylmetoxyphenols, tocopherols or ubichinones and a basic polymer. Use of a transdermal therapeutic system (TTS) comprising a pharmaceutical layer containing at least one matrix having an active ingredient and/or an active ingredient reservoir

a diffusion barrier that is permeable to said active ingredient and arranged on the skin side of the active ingredient reservoir

and an ergoline derivative or salt thereof as an active ingredient for producing an agent for obtaining and maintaining the circadian rhythm under dopamine therapy.

The invention relates to the use of a transdermal therapeutic system (TTS) comprising a medicinal layer, which contains at least one matrix comprising an active ingredient and/or an active ingredient reservoir and a diffusion barrier situated on the skin side of the active ingredient reservoir and permeable to active ingredients, in addition to, an ergoline-derivative or physiologically compatible salt with an acid thereof, as an active ingredient, for producing a means for treating the Restless Leg Syndrome and Periodic Limb Movement Disorder.

The invention relates to the use of a dopamine agonist in the form of an agent consisting of at least two spatially discrete compositions, of which one is a transdermal therapeutic system (TTS) containing the dopaminergic agent and another one or more are preparations for oral and/or parenteral application containing that same dopaminergic agent for the treatment of dopaminergically treatable diseases with the following elements: a) the TTS is continuously applied, b) within the duration of application in a) the composition for oral or parenteral dosage is administered.

Priority: DE20001043321 Applic. Date: 2000-08-24; DE20031041317 Applic. Date: 2003-09-03; DE20001053397 Applic. Date: 2000-10-20; WO2004DE01133 Applic. Date: 2004-05-30; US2003-362248 Applic. Date: 2003-07-07; WO2001EP09824 Applic. Date: 2001-08-24; US2003-362183 Applic. Date: 2003-07-21; WO2001EP09823 Applic. Date: 2001-08-24; US2003-362182 Applic. Date: 2003-07-03; WO2001EP09826 Applic. Date: 2001-08-24

Inventor: WINDT-HANKE FRED [DE]; GUNTHER CLEMENS [DE]; HOROWSKI REINHARD [DE]; TACK JOHANNES [DE]; ENGFER ADALBERT [DE]; BOSTEDT KATALIN T [DE]; SCHENK DIRK [DE]

Title: Use of inositol-tripyrophosphate in treating tumors and diseases

Applicant/Assignee:

Application No.: 11/175979   Filing Date: 06/Jul/2005

Abstract:Inositol-tripyrophosphate is an allosteric effector of hemoglobin due to its ability to cross the plasma membrane of red blood cells and deliver oxygen to solid tumors, by lowering the oxygen affinity of the hemoglobin of red blood cells. The present invention is directed to the use of inositol-tripyrophosphate to reduce hemoglobin's affinity for oxygen in circulating red blood cells. The present invention is further directed to the use of inositol-tripyrophosphate to inhibit angiogenesis and enhance radiation sensitivity of hypoxic tumors. The present invention is further directed to the use of inositol-tripyrophosphate to enhance PO2 in hypoxic tumors.

Priority: US20040585804P Applic. Date: 2004-07-06

Inventor: NICOLAU CLAUDE [US]; GREFERATH RUTH [DE]; FYLAKTAKIDOU KONSTANTINA C [GR]; LEHN JEAN-MARIE [FR]

Title: Cosmetic compositions containing Sophora alopecuroides L. extracts

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 10/997204   Filing Date: 24/Nov/2004

Abstract:Disclosed are extracts of Sophora alopecuroides L. as cosmetic skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle. Also disclosed are active ingredients in the extracts, including Alopecurone A, Alopecurone B, Sophoraflavone-G, Sophoraflavone-I, Sophoraflavone-K, and mixtures thereof. The inventive extracts, compositions and methods have effective skin lightening properties, may be easier to deliver to the skin and are available in nature.

Priority:

Inventor: HARICHIAN BIJAN [US]; ZOU MINLIANG [CN]; WANG HONGQIANG [CN]

Title: Organo-gel formulations for therapeutic applications

Applicant/Assignee: MEDIQUEST THERAPEUTICS, INC

Application No.: 11/246296   Filing Date: 11/Oct/2005

Abstract:A composition suitable for the local delivery of cosmetic and/or pharmaceutical agents into the skin containing at least two biocompatible organic solvents, a polar lipid, a surfactant, water, urea and a thickener wherein the organic solvents include an ester and a dihydric and/or polyhydric alcohol is provided. Also disclosed are compositions that further contain a cosmetic and/or pharmaceutical agent, along with the preparation and use thereof.

Priority: US2005-150254 Applic. Date: 2005-06-13; US2005-066485 Applic. Date: 2005-02-28; US2004-960516 Applic. Date: 2004-10-08

Inventor: DECHOW FREDERICK J [US]

Title: Cosmetic or dermopharmaceutical compositions comprising tyramine derivatives, method for preparing same, and use thereof

Applicant/Assignee: SEDERMA SAS

Application No.: 10/519118   Filing Date: 29/Sep/2005

Abstract:The invention concerns cosmetic or dermopharmaceutical compositions comprising tyramine derivatives and their salts. The invention also concerns the method for preparing same and use thereof for reducing pigmaentation.

Priority: FR20020007965 Applic. Date: 2002-06-26; WO2003FR01950 Applic. Date: 2003-06-25

Inventor: LINTNER KARL [FR]

Title: Linkage of agents using microparticles

Applicant/Assignee: PERICOR SCIENCE, INC

Application No.: 11/125830   Filing Date: 10/May/2005

Abstract:Methods, products and kits are provided for attaching agents to a skin surface via microparticles using endogenous or exogenous transglutaminase.

Priority: US2000-620783 Applic. Date: 2000-07-21; US1999-359920 Applic. Date: 1999-07-22; US1999-234358 Applic. Date: 1999-01-20; US19980071908P Applic. Date: 1998-01-20

Inventor: GREEN HOWARD [US]; COMPTON BRUCE J [US]; COREY GEORGE D [US]; DJIAN PHILIPPE [FR]

Title: Novel Molecules dervied from noraporphine

Applicant/Assignee: SEDERMA SAS

Application No.: 10/525985   Filing Date: 15/Sep/2005

Abstract:The invention concerns novel molecules derived from noraporphine, as well as cosmetic and dermopharmaceutical compositions containing one or several of said derivatives, alone or combined with a plant extract, in particular glaucium flavum, and particularly preparations for reducing pigmentation, with anti-ageing effect or for slimming.

Priority: FR20020010810 Applic. Date: 2002-08-30; WO2003FR02400 Applic. Date: 2003-07-29

Inventor: LINTNER KARL [FR]

Title: Pharmaceutical composition

Applicant/Assignee:

Application No.: 11/257348   Filing Date: 24/Oct/2005

Abstract:The present invention relates to formulations useful for treating respiratory disorders associated with the production of mucus glycoprotein, skin disorders, and allergic conjunctivitis while substantially reducing adverse effects associated with the administration of non-selective anti-cholinergic agents and methods of use thereof.

Priority: US20040622507P Applic. Date: 2004-10-27; US20040621783P Applic. Date: 2004-10-25

Inventor: LORBER RICHARD R [US]; STAUDINGER HERIBERT W [US]; WARD ROBERT E [US]

Title: Derivatized polysaccharide polymer

Applicant/Assignee: RHODIA INC

Application No.: 11/282501   Filing Date: 18/Nov/2005

Abstract:Derivatized polysaccharide polymers that contain a fructan polymer substrate bearing one or more cationic substituent groups are useful in home and fabric care applications, in oilfield applications, and in emulsion polymerization applications.

Priority: US20040629402P Applic. Date: 2004-11-19

Inventor: GUNN EUEN [US]; GABBIANELLI ALVINO [US]; CROOKS REGAN [US]; SHANMUGANANDAMURTHY KRISHNAMUR [US]

Title: 2,4-Diamino quinazoline and pyridopyrimidine ester derivatives as dihydrofolate reductase inhibitors

Applicant/Assignee:

Application No.: 10/525906   Filing Date: 14/Nov/2005

Abstract:The invention provides novel compounds or the formula II: wherein R1, R2, R3 and R4 are independently hydrogen of a group that liberates the free amine in vivo, for example -CO-alkyl, preferably -CO-C1-C3 alkyl or pivalate

or -COhaloalkyl, preferably -CO-C1-C3 haloalkyl, most preferably -CO-C1-C3 chloroalkyl

wherein W is: and @ denotes the points of attachment and wherein the ester can be located in either direction

wherein n and m are independently 0-5

wherein one but not both or X and Y can be nitrogen, or X is C-A and/or Y is C-B

wherein A and B are independently selected from hydrogen, alkyl optionally substituted with a halogen, an electron donor group such as amino, alkylamino, dialkylamino or hydroxy, or an electron acceptor group such as nitro, cyano. trihaloalkyl or amido, alkoxy or halogen

and pharmacologically acceptable salts thereof. Provided that when R1 to R4 are hydrogen, both X and Y are C-H, n is 1 and -(CH2)n- is attached to the bridging oxygen of the ester group W, then m cannot be 0 or 1.

Priority: GB20020019897 Applic. Date: 2002-08-27; WO2003GB03714 Applic. Date: 2003-08-27

Inventor: HALLBERG ANDERS [SE]; GRAFFNER-NORDBERG MALIN [SE]; BOMAN ARNE [SE]; SEIFERT ELISABETH [SE]

Title: Octahydropyrrolo[3,4-C]pyrrole derivatives

Applicant/Assignee:

Application No.: 11/285653   Filing Date: 21/Nov/2005

Abstract:The present invention relates to octahydropyrrolo[3,4-c]pyrrole derivatives of formula (I): and to processes for the preparation thereof, compositions containing the same and the uses thereof.

Priority: EP20040106044 Applic. Date: 2004-11-24; EP20050100474 Applic. Date: 2005-01-26; US20050664619P Applic. Date: 2005-03-22

Inventor: LANE CHARLOTTE A L [GB]; PRICE DAVID A [GB]

Title: Use of diindolylmethane-related indoles and growth factor receptor inhibitors for the treatment of human cytomegalovirus-associated disease

Applicant/Assignee:

Application No.: 11/260543   Filing Date: 26/Oct/2005

Abstract:The present invention includes compositions and methods for the treatment and prevention of conditions associated with Human Cytomegalovirus (HCMV) infection. HCMV-associated conditions include infections (active and latent), benign cell-proliferative conditions, pre-cancerous cell-proliferative conditions, and cancerous conditions. In particular, the present invention describes new therapeutic and preventative uses for 3,3'-diindolylmethane (DIM), or a DIM-related indole, in combination with an inhibitor of a membrane bound Growth Factor Receptor (GFR), to treat conditions associated with exposure to HCMV. In certain embodiments, the compositions of the invention can be used in combination with radiation therapy.

Priority: US20040622333P Applic. Date: 2004-10-26

Inventor: ZELIGS MICHAEL A [US]

Title: Instantaneous ultrasonic measurement of bladder volume

Applicant/Assignee:

Application No.: 10/523681   Filing Date: 23/Sep/2005

Abstract:An apparatus and methods to quantify the volume of urine in a human bladder with a limited number of acoustic beams is disclosed. In a first version the apparatus is composed of a transducers assembly that transmits a plurality of narrow ultrasound beams in different directions towards the bladder and receives the returning ultrasound signals

a receiver detector for processing the returned signals

an analog-to-digital converter

a memory to store the digitized data and a volume display allowing to define the optimal position of the transducer assembly. The apparatus also includes a signal processing software that automatically determines the bladder Depth D and Height H and computes the volume of urine using an empirical formula corrected by specific, empirically measured, filling dependant correction factors. In a second version a single wide angle ultrasound beam transducer transmitting ultrasound signals at fundamental frequency is used to quantify the urine volume. Return signals originating from a depth beyond the usual position of the posterior wall depth of a filled bladder are analyzed for presence of higher harmonic signals which in turn are related to presence or absence of urine. Both methods or a combination thereof can be used us a simple warning device for presence of residual urine after voiding or indicate the presence of a critical bladder urine filling level.

Priority: GB20020018547 Applic. Date: 2002-08-09; WO2003EP07807 Applic. Date: 2003-07-01

Inventor: MCMORROW GERALD [US]; BAARTMANS HENRI [NL]; BOM NICOLAAS [NL]; LANCEE CHARLES T [NL]

Title: Solid personal care composition

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 11/289058   Filing Date: 29/Nov/2005

Abstract:Disclosed is a personal care composition comprising: (a) at least a solid hydrophobic component

and (b) no more than 25% by weight of the composition of a soap component, and the composition having: (i) a needle penetration, as measured according to the ASTM Test Method D5, of from about 1 to about 40 at 25 DEG C.

(ii) a yield stress of at least about 1500 Pa at 25 DEG C.

and (iii) a viscosity of between about 1 mPas and about 10,000,000 mPas at 100 DEG C.

Priority: US20040631385P Applic. Date: 2004-11-29

Inventor: HATANO SATORU [JP]; LAM VIRGINIA A [US]

Title: Heat exchanger of ventilating sytem

Applicant/Assignee: LG ELECTRONICS INC

Application No.: 10/538070   Filing Date: 04/Feb/2003

Abstract:A heat exchanger of a ventilating system includes: heat exchange plates having first air passage through which indoor air being discharged to outside of a building passes and a second air passage through which outdoor air of the building passes which are sequentially formed: first corrugation plates attached to the first air passage

and second corrugation plates attached to the second air passage, wherein the heat exchange plates are made of a paper material with numerous fine holes that are able to generate a capillary phenomenon and loess which radiates far infrared ray. Heat exchange and moisture exchange between the indoor air and the outdoor air are performed simultaneously, and a cleaning function of removing a harmful material contained in outdoor air can be carried out.

Priority: WO2003KR00245 Applic. Date: 2003-02-04

Inventor: LEE SEONG-HWAN [KR]; SHIN SOO-YEON [KR]

Title: Underarm cosmetic method and compositions

Applicant/Assignee: CONOPCO INC, D/B/A UNILEVER

Application No.: 11/284298   Filing Date: 21/Nov/2005

Abstract:A method of inhibiting skin darkening whilst inhibiting perspiration in the underarm which comprises incorporating into a antiperspirant composition comprising an astringent salt comprising an aluminium and/or zirconium salt, a triglyceride oil and optionally an active acid comprising an aliphatic dicarboxylic acid, especially C6-C12 such as azelaic acid, an unsaturated C18 aliphatic carboxylic acid such as a linoleic acid or an hydroxybenzoic acid such as salicylic acid, at a ratio to said astringent salts, x:y, of 1:<4 in which x represents the weight concentration of said triglyceride oil plus 4 times the weight concentration of active carboxylic acid and y represents the weight concentration of said astringent salts. The composition can additionally comprise glycerol and/or a chelating agent for a transition metal.

Priority: GB20040025945 Applic. Date: 2004-11-26

Inventor: JAMES ALEXANDER G [GB]; MARTI VERNON P J [GB]; PATERSON SARAH E [GB]; POPLE JENNIFER E [GB]; TURNER GRAHAM A [GB]

Title: Disease treatment via antimicrobial peptide inhibitors

Applicant/Assignee:

Application No.: 10/539558   Filing Date: 17/Jun/2005

Abstract:A method of treating a disease in a subject in need thereof is disclosed. The method comprises providing to the subject a therapeutically effective amount of a compound being capable of decreasing an activity and/or level of an antimicrobial peptide (AMP) and/or AMP-like molecule, thereby treating the disease in the subject in need thereof.

Priority: IL20020153557 Applic. Date: 2002-12-19; IL20030156980 Applic. Date: 2003-07-17; WO2003IL01094 Applic. Date: 2003-12-21

Inventor: HILLMAN YITZCHAK [IL]

Title: Cosmetic compositions comprising a fine and porous powder

Applicant/Assignee: ARKEMA FRANCE

Application No.: 11/268967   Filing Date: 08/Nov/2005

Abstract:Our invention is a water/oil emulsion comprising a porous powder, the particles of the powder having the following characteristics: an apparent specific surface of 1 to 299 m<2>/g, measured by nitrogen absorption according to the ISO 9277 BET method

a linseed oil absorption of between 45 g/100 g of powder and 160 g/100 g of powder, measured according to ISO 787-5. The mean diameter of the particles of the powder is between 2 mum and 100 mum, preferably from 2 to 50 mum, more advantageously still from 2 to 20 mum. The powder is chosen from a powder formed of polyamides, of polyesteramides, of polyurethanes, of poly(methyl methacrylate)s, of acrylic polymers, of polyesters, of silicones, of polyethylenes and of silicas.

Another subject-matter of our invention is the use of the emulsion for obtaining a make-up and/or care product for the skin which is nonshiny, nonoily, nonsticky and/or nontacky, as well as the use of the fine powder for improving the feel and/or the appearance of a cosmetic emulsion.

Priority: FR20040012690 Applic. Date: 2004-11-30

Inventor: LOYEN KARINE [FR]; KOHLER SOPHIE [FR]

Title: Cytochrome p450ra1-2 and related proteins

Applicant/Assignee: CYTOCHROMA INC

Application No.: 10/148883   Filing Date: 13/Feb/2003

Abstract:The present invention provides a novel all-trans-RA inducible all-trans-RA metabolizing cytochrome P450, P450RAI-2, that is predominantly expressed in the brain, cerebellum in particular. Human P450RAI-2 show 42% amino acid identity to human P450RAI-1 and when transfected into COS-1 cells causes the rapid conversion of all-trans-RA into more polar metabolites including the inactive products 4-oxo-RA, 4-OH-RA and 18-OH-RA. P450RAI-2, as with P450RAI-1, is also inducible in certain cultured cell lines exposed to all-trans-RA. Methods for and uses of the new polynucleotide, polypeptide, fragments thereof and inhibitors thereof, include the treatment of dermatological disorders and cancer.

Priority: US20000178314P Applic. Date: 2000-01-27; US19990171110P Applic. Date: 1999-12-16; WO2000CA01493 Applic. Date: 2000-12-15

Inventor: WHITE JAY [CA]; PETKOVICH MARTIN P [CA]; JONES GLENVILLE [CA]; RAMSHAW HEATHER [CA]

Title: Method for identifying and treating photodamaged skin

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 10/998685   Filing Date: 29/Nov/2004

Abstract:The present invention relates to modulation of MAP2K2 and DUSP-1 genes and proteins encoded thereby. More specifically, the present invention relates to modulation of MAP2K2 and DUSP-1 genes to detect and condition photo-damaged skin, preferably, chronically photo-damaged skin, as well as to identify active compounds and compositions for skin conditioning.

Priority:

Inventor: IOBST SUSANNE T [US]; SCHILLING KURT M [US]; BOYD CHARLES D [US]; URSCHITZ JOHANN G E [US]; OKIMOTO GORDON S [US]

Title: Method of administering anti-angiogenic agents and a method of treating disease using same

Applicant/Assignee:

Application No.: 11/288989   Filing Date: 29/Nov/2005

Abstract:A method of administering an anti-angiogenic agent to a human or an animal comprising administering the anti-angiogenic agent such that a plasma concentration of the anti-angiogenic agent in the human or animal is substantially continuously maintained above 1 ng/mL.

Priority: US20040631502P Applic. Date: 2004-11-29; US20050715238P Applic. Date: 2005-09-08; US20050732065P Applic. Date: 2005-11-01

Inventor: FOGLER WILLIAM E [US]; SIDOR CAROLYN [US]; TRESTON ANTHONY M [US]; VOLKER KIRK M [US]

Title: Composition containing a silicone copolymer and an AMPS-like polymer and/or organic powder

Applicant/Assignee: L'OREAL

Application No.: 11/324431   Filing Date: 04/Jan/2006

Abstract:A composition containing, in a physiologically acceptable medium, (1) at least one aqueous phase containing particles of a substantially linear block silicone copolymer, and (2) at least one polymer containing at least one monomer having an ethylenic unsaturation and a sulphonic group, and/or at least on organic powder.

Priority: FR20020000097 Applic. Date: 2002-01-04; FR20020000099 Applic. Date: 2002-01-04; FR20020000095 Applic. Date: 2002-01-04; FR20020000096 Applic. Date: 2002-01-04; US2003-334979 Applic. Date: 2003-01-02

Inventor: LENNON PAULA [FR]

Title: Inextensible headgear and cpap or ventilator mask assembly with same

Applicant/Assignee:

Application No.: 10/523607   Filing Date: 10/Mar/2005

Abstract:A headgear ( 200 ) for a respiratory mask ( 202 ) of a ventilator or CPAP device is provided. The headgear includes a strap portion ( 204, 206 ) formed of a substantially inextensible material. The strap portion has formed on one end thereof a connecting structure configured to connect to a mask of the ventilator or CPAP device. One advantage is that the mask will not or at least will be less inclined to lift off the face as mask pressure is increased.

Priority: US20020400686P Applic. Date: 2002-08-05; WO2003AU00988 Applic. Date: 2003-08-05

Inventor: BERTHON-JONES MICHAEL [AU]; GUNARATNAM MICHAEL K [AU]; BATEMAN PETER E [AU]; JENKINSON PHILIP J [AU]; MALOUF GORDON J [AU]

Title: Novel dermatological composition using bio-activating organocatalysts

Applicant/Assignee:

Application No.: 11/292227   Filing Date: 01/Dec/2005

Abstract:The invention provides novel dermatological compositions and related methods useful in the activation of skin growth factors and growth receptors. Compositions of the invention act upon follicle cells and other skin targets to induce hair growth, facilitate dermal cell repair, and enhance skin health. Compositions comprise a bio-activating organocatalyst in a pharmaceutically acceptable carrier, adapted for use on an animal's skin or hair.

Priority: US20040632479P Applic. Date: 2004-12-02

Inventor: EBERL JAMES J [US]

Title: Mild cleaning preparation

Applicant/Assignee:

Application No.: 10/534970   Filing Date: 21/Dec/2005

Abstract:Cosmetic preparation containing a) at least two surfactants from the group of the compounds sodium lauryl sarcosinate, sodium monoalkylphosphate, disodium lauryl sulfosuccinate, disodium cocoyl glutamate, alpha-olefin sulfonate and lauryl glucoside, with a total surfactant concentration of 3 to 1% by weight, b) one or more hydrocolloids in a total concentration of 0.05 to 1% by weight, c) one or more water-soluble salts in a concentration of 1 to 4 % by weight, respectively based on the total weight of the preparation, in addition to optionally further cosmetic or dermatological active ingredients, auxiliary agents and additives and water.

Priority: DE20021036063 Applic. Date: 2002-08-07; WO2003EP07704 Applic. Date: 2003-07-16

Inventor: ALBRECHT HARALD [DE]; KOCH PETER [DE]; RUPPERT STEPHAN [DE]; KOHUT MICHAELA [DE]

Title: Method of preventive treatment of allergy by mucosal administration of an allergy vaccine

Applicant/Assignee: ALK-ABELLO A/S

Application No.: 11/269681   Filing Date: 09/Nov/2005

Abstract:The present invention relates to a method of preventive treatment of allergy to an allergen in a subject comprising administering an allergy vaccine containing the allergen as active substance to a mucosal surface of the subject, a) wherein the subject to be treated is sensitised so as to exhibit an IgE response specific to the allergen, b) wherein the subject to be treated is free of clinical symptoms of the allergy associated with the allergen, and c) wherein the preventive treatment is aimed at preventing or reducing subsequent clinical symptoms of the allergy associated with the allergen.

Priority: DK20040001730 Applic. Date: 2004-11-10; US20040626454P Applic. Date: 2004-11-10; US20050686914P Applic. Date: 2005-06-03

Inventor: BRIMNES JENS [DK]; KILDSGAARD JENS [DK]

Title: Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins

Applicant/Assignee: DUKE UNIVERSITY

Application No.: 11/334689   Filing Date: 18/Jan/2006

Abstract:A method for treating hair loss in mammals uses compositions containing prostaglandins analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.

Priority: US2001-774556 Applic. Date: 2001-01-31; US20000193844P Applic. Date: 2000-03-31

Inventor: DELONG MITCHELL A [US]; MCIVER JOHN M [US]; YOUNGQUIST ROBERT S [US]

Title: Treatment articles capable of conforming to an underlying shape

Applicant/Assignee:

Application No.: 11/270949   Filing Date: 12/Nov/2005

Abstract:Treatment articles capable of conforming to an underlying shape and methods for their use are provided. The articles comprise a water insoluble substrate having at least one elongation zone where at least a portion of the elongation zone has been incrementally stretched. The article also includes a treatment composition which preferably delivers a skin care active. Preferred articles of the present invention comprise facial treatment masks.

Priority: US20040627566P Applic. Date: 2004-11-12

Inventor: LODGE RICHARD W [US]; MIYAMOTO MIWA [JP]; MIYAMOTO KOUICHI [JP]; OHNISHI KAZUYUKI [JP]

Title: Process for making nonwoven articles

Applicant/Assignee: NATIONAL STARCH AND CHEMICAL INVESTMENT HOLDING CORPORATION

Application No.: 11/276191   Filing Date: 17/Feb/2006

Abstract:Method for preparing an active-containing nonwoven article involving fixing active ingredients on the surface of non-woven webs and cellulosic mats. The active ingredients can be released (deposited) onto a surface by normal triggering mechanisms, which include the action of a liquid or by friction or rubbing. The fixative systems described herein provide the ability to control high load levels while not interfering with wettability of the fabric or paper. Additionally, ingredients incompatible and reactive with each other can be treated onto the same web and kept as separate particles fixed to the surface until released.

Priority: US2003-639845 Applic. Date: 2003-08-13; US2002-219548 Applic. Date: 2002-08-15

Inventor: SOLAREK DANIEL B [US]

Title: Method for oxygen treatment of intact skin

Applicant/Assignee:

Application No.: 11/269433   Filing Date: 08/Nov/2005

Abstract:Oxygen therapy for healthy or inflamed but intact skin involves placing an oxygen-generating dressing onto the skin to be treated, the oxygen-generating bandage being a one-time use dressing capable of generating oxygen for only a short period of time, not to exceed about 4 hours.

Priority: US20040634322P Applic. Date: 2004-12-08

Inventor: LADIZINSKY DANIEL A [US]

Title: Transdermal systems for the delivery of estrogens and progestins

Applicant/Assignee:

Application No.: 11/237284   Filing Date: 27/Sep/2005

Abstract:Transdermal systems are provided for administering an estrogen and/or a progestin to a mammalian female. The systems are monolithic, having a drug reservoir that serves as the means for ensuring adhesion to the skin during drug administration. The drug reservoir includes the active agent(s), a low molecular weight organic acid as a permeation enhancer, and an additional vehicle, in an adhesive matrix. Methods for using the systems for transdermal delivery of active agents are also provided, including methods for providing hormone replacement therapy and for preventing ovulation.

Priority: US20040613663P Applic. Date: 2004-09-27

Inventor: CHIANG CHIA-MING [US]

Title: Antioxidant dietary supplement compositions and methods for maintaining healthy skin

Applicant/Assignee:

Application No.: 11/273514   Filing Date: 14/Nov/2005

Abstract:Compositions and methods for maintaining healthy skin and alleviating skin conditions such as redness, inflammation, irritation and skin aging, as well as for maintaining healthy scalp and hair are disclosed. The oral compositions disclosed comprise antioxidants including lycopene, gallic acid and ascorbic acid. Preferably lycopene has been water-extracted, more preferably under acid conditions. In the method of treatment aspect of the invention, an oral composition containing antioxidant(s) is administered to a person concurrently with a topical treatment for said skin conditions. Preferred topical compositions comprise cyclohexane polyols, such as cyclohexanediol or cyclohexanetriol.

Priority: US20040632481P Applic. Date: 2004-12-02; US20050708498P Applic. Date: 2005-08-16

Inventor: CHOMCZYNSKI PIOTR [US]

Title: High throughput screening of aptamer libraries for specific binding to proteins on viruses and other pathogens

Applicant/Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Application No.: 10/851947   Filing Date: 20/May/2004

Abstract:The present invention includes composition and methods for making and using a combinatorial library to identify thioaptamers that bind to targets on or about pathogens. Compositions, kits and methods are also provided for the identification of pathogens, e.g., viral, bacterial or other proteins related infectious disease, as well as, vaccines and vaccine adjuvants are provided that modify host immune responses.

Priority: US20030472897P Applic. Date: 2003-05-23

Inventor: GORENSTEIN DAVID G [US]; LUXON BRUCE A [US]; BARRETT ALLAN [US]; HOLBROOK MICHAEL [US]; BASSETT SUZANNE [US]; SOMASUNDERAM ANOMA [US]

Title: Combination preparation of hyaluronic acid and at least oe local anesthetic and the use thereof

Applicant/Assignee:

Application No.: 10/529924   Filing Date: 28/Nov/2005

Abstract:The invention relates to a combination preparation comprising an active agent A from the group hyaluronic acid, the salts and fragments thereof, at least one active agent B from the group of local anaesthetics and derivatives thereof and also if necessary further additives. These combination preparations are used for the medical treatment of degenerative and traumatic diseases of all joints, for the treatment of articular cartilage and cartilage bone defects and also meniscus and intervertebral disc lesions, such as e.g. arthrosis, articular rheumatism, osteochondritis dissecans, flake fractures, meniscus lesions and for the treatment of skin and mucous membrane changes, also from cosmetic aspects.

Priority: DE20021046340 Applic. Date: 2002-10-04; WO2003EP10822 Applic. Date: 2003-09-30

Inventor: WOHLRAB DAVID [DE]

Title: Cosmetic use of a composition containing at least one oxazoline, serving as an active substance, as a slimming product and/or for preventing and/or treating cellulite

Applicant/Assignee: LABORATOIRES EXPANSCIENCE

Application No.: 10/561173   Filing Date: 16/Dec/2005

Abstract:The invention relates to the cosmetic use of a composition containing at least one oxazoline, serving as an active substance, as a slimming product, and to an associated cosmetic treatment method. The invention also relates to the cosmetic use of a composition containing at least one oxazoline, serving as an active substance, for preventing and/or treating cellulite.

Priority: FR20030007333 Applic. Date: 2003-06-18; WO2004FR01504 Applic. Date: 2004-06-17

Inventor: MSIKA PHILIPPE [FR]; PICCIRLLI ANTOINE [FR]; PICCARDI NATHALIE [FR]

Title: Method for treating inflammatory disorders

Applicant/Assignee:

Application No.: 11/292007   Filing Date: 02/Dec/2005

Abstract:The invention features a method of treating an inflammatory disorder, such as sepsis, in a subject. The method involves administering to the subject an antagonist of cIAP2 expression and/or function, so that the disorder is treated.

Priority: US20040632952P Applic. Date: 2004-12-06

Inventor: KORNELUK ROBERT G [CA]; HOLCIK MARTIN [CA]; CONTE DAMIANO [CA]; LEFEBVRE CHARLES [CA]; LACASSE ERIC [CA]

Title: Use of water structurants to provide fabric care benefits in a non-aqueous fabric treatment system

Applicant/Assignee: THE PROCTER & GAMBLE & COMPANY

Application No.: 11/345414   Filing Date: 01/Feb/2006

Abstract:Water structurants are used in combination with a lipophilic fluid and water to deliver fabric care benefits to a fabric article in a non-aqueous fabric treatment system. Water structurants are effective in minimizing fabric damages (e.g., shrinkage, pilling, loss of shapes) from the fabric treatment process. Compositions comprising the water structurants for use in a non-aqueous fabric treating process are also disclosed. The compositions are capable of delivering the fabric care benefits to the fabric article and minimizing fabric damages.

Priority: US2002-238293 Applic. Date: 2002-09-10; US20050650395P Applic. Date: 2005-02-04; US20050687079P Applic. Date: 2005-06-03

Inventor: WANG JIPING [US]; FLEISCH KELLI A [US]; GARDNER ROBB R [US]; RADOMYSELSKI ARSENI V [US]

Title: Composition and method of a topical treatment of neurodermatitis

Applicant/Assignee: BIONICS PHARMA GMBH

Application No.: 11/272881   Filing Date: 15/Nov/2005

Abstract:A composition for the topical treatment of dermal irritation and pain symptoms of neurodermatitis comprising a topical pharmaceutical formulation which contains a therapeutically appropriate dose of a sodium channel blocker selected from the group of ester- or amide-type local anesthetics, wherein the sodium channel blocker is released directly on or in the skin underneath the applied pharmaceutical formulation.

Priority: DE200410059613 Applic. Date: 2004-12-10

Inventor: LIEDTKE RAINER K [DE]

Title: Administration of urea compounds for combating signs of cutaneous aging

Applicant/Assignee: L'OREAL

Application No.: 11/260139   Filing Date: 28/Oct/2005

Abstract:Signs of aging of the skin and/or mucous membranes are prevented and/or reduced, and the activity of the proteolytic enzymes of the stratum corneum are stimulated as well, by administering to an individual in need of such treatment, a cosmetic/pharmaceutical composition which comprises a thus effective amount of at least one hydroxylated urea compound having the following formula (I): in which: the radicals R1, R2, R3 and R4, which may be identical or different, are each a hydrogen atom, a C1-C4 alkyl radical or a C2-C6 hydroxyalkyl radical which can contain from 1 to 5 hydroxyl groups, wherein at least one of the R1 to R4 radicals represents a hydroxyalkyl radical, or salt, solvate or isomer thereof, formulated into a physiologically acceptable medium therefor.

Priority: FR20040011783 Applic. Date: 2004-11-04; US20040634540P Applic. Date: 2004-12-10

Inventor: BERNARD DOMINIQUE [FR]; SIMONETTI LUCIE [FR]

Title: ASB transcription repressor proteins and nucleic acids and their application in expansion of stem cells

Applicant/Assignee:

Application No.: 10/536491   Filing Date: 25/Nov/2003

Abstract:The present invention relates to methods for expansion of stem or progenitor cells. These methods rely on Asb-a polypeptides or nucleic acids to temporarily suppress differentiation of the cells, thus allowing proliferation and self-renewal of the stem or progenitor cells. Abs-a polypeptides and coding sequences define a class of polypeptides and nucleic acids that are both structurally and functionally highly conserved among vertebrates. Asb-a polypeptides contain 6 ankyrin repeats and a SOCS box that mediate the effect of the polypeptide on the regulation of specific subsets of genes involved in differentiation. The invention discloses various methods to increase the intracellular concentration of an Asb-a polypeptide for suppression of terminal differentiation of the stem or progenitor cells. The invention further relates to Asb-a polypeptides and nucleic acids, vectors and host cells for use in methods for their production and for use in the method for expansion of stem or progenitor cells, as well as to stem or progenitor cells containing exogenous Asb-a polypeptides and nucleic acids.

Priority: EP20020079903 Applic. Date: 2002-11-25; WO2003NL00831 Applic. Date: 2003-11-25

Inventor: PEPPELENBOSCH MAIKEL P [NL]; ZIVKOVIC DANICA [NL]; DIKS SANDER [NL]; BINK ROBERT J [NL]

Title: Antibodies to Dkk-1

Applicant/Assignee: AMGEN INC

Application No.: 11/197665   Filing Date: 04/Aug/2005

Abstract:The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.

Priority: US20040598791P Applic. Date: 2004-08-04

Inventor: LI JI [US]; SHEN WENYAN [US]; LU HSIENG S [US]; RICHARDS WILLIAM G [US]

Title: Cosmetic effervescent cleansing pillow with rupturable packet

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 11/010253   Filing Date: 13/Dec/2004

Abstract:A cleansing article is provided which includes an effervescent cleanser composition held within a rupturable packet and the packet is held within a porous receptacle. The effervescent cleanser composition is an intimate mixture of an acid material such as citric acid, an alkaline material such as sodium bicarbonate, and a surfactant.

Priority:

Inventor: ROSS MICHAEL E [US]; STEIGER DENNIS I [US]

Title: Controlled-Release of Cosmetic and Pharmaceutical Agents via Osmotic Nano-Diffusion from Zeolite Cage Complexes

Applicant/Assignee: BIODERM RESEARCH

Application No.: 11/307824   Filing Date: 24/Feb/2006

Abstract:The present invention discloses the application of cage complexes of zeolites for topical controlled delivery of organic cosmetic and pharmaceutical active agents. The treatment and protection of skin surface requires that certain organic cosmetic and pharmaceutical active agents be delivered slowly and allowed to remain on skin surface for extended periods. Zeolite cage complexes of the present invention do not absorb into skin and affect a controlled release of cosmetic and pharmaceutical agents by an osmotic nano-diffusion method upon contact with water. Topical treatments that includes skin aging, anti-wrinkle, antioxidants, skin whitening, acne, rosacea, sun screens, UV blocks, anesthetics, skin soothers, anti-irritants, anti-inflammatory agents, vitamins, hormones, and such that require a controlled release of active agents are now practical by the present invention.

Priority: US2003-418495 Applic. Date: 2003-04-18

Inventor: GUPTA SHYAM K [US]

Title: Regulation of mammalian hair growth

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 11/344771   Filing Date: 01/Feb/2006

Abstract:The present invention relates to a topical skin care composition containing a safe and effective amount of a skin care active comprising agmatine, and its salt

a safe and effective amount of a first additional skin care active selected from the group consisting of BHT or BHA, hexamidine, cetyl pyridinium chloride, green tea catechins, phytosterols, ursolic acid, compounds derived from plant extracts, their salts and derivatives

and a dermatologically acceptable carrier for the agmatine composition. The present invention also relates to methods of using such agmatine compositions to regulate hair growth and the condition of mammalian skin. Said methods generally comprise the step of topically applying the composition to the skin of a mammal needing such treatment, a safe and effective amount of such compositions.

Priority: US2004-783151 Applic. Date: 2004-02-19; US20030451910P Applic. Date: 2003-03-04

Inventor: OBLONG JOHN E [US]; MCPHAIL SARA J [US]; MCARTHUR SHANNON C [US]; BASCOM CHARLES C [US]; EICKHOFF DAVID J [US]; MCIVER JOHN M [US]

Title: Composition for cytocompatible, injectable, self-gelling chitosan solutions for encapsulating and delivering live cells or biologically active factors

Applicant/Assignee:

Application No.: 10/521524   Filing Date: 20/Sep/2005

Abstract:The present invention provides compositions and methods for tissue repair using a cytocompatible self-gelling cross-linked hydrogel. The composition comprises a biocompatible mixture of chitosan, bifunctional dialdehyde, and hydroxylated polymer, which can be used to immobilize or encapsulate viable cells, or bioactive substances. The method includes the process of mixing bioactive substances, live cells, and/or extracellular matrix components with a cross-linking solution comprising a bifunctional aldehyde-treated hydroxylated polymer such as hydroxyethyl cellulose. The cross-linking solution is then mixed homogenously with a neutral isotonic chitosan solution. The chitosan becomes cross-linked by the bifunctional aldehyde, while the cells are protected from potentially nocive effects of the aldehyde cross-linker by the hydroxylated polymer. The injectable solution retains cell viability and bioactivity, and immobilizes cells at the site of injection or delivery. Depending on the particular application, mixtures of chitosan and bifunctional dialdehyde may be employed. The injectable solution also liberates bioactive substances with controlled release kinetics from the site of injection.

Priority: US20020395991P Applic. Date: 2002-07-16; WO2003CA01069 Applic. Date: 2003-07-16

Inventor: HOEMANN CAROLINE [CA]; CHENITE ABDELLATIF [CA]; BUSCHMANN MICHAEL [CA]; SARREQI ALESSIO [CA]; SUN JUN [CA]

Title: Enzyme stabilization

Applicant/Assignee:

Application No.: 11/297697   Filing Date: 08/Dec/2005

Abstract:A method is disclosed for stabilizing liquid enzyme-containing liquid formulations by adding at least one boron compound and at least one alpha-hydroxy-mono-carboxylic acid or the salt of an alpha-hydroxy-mono-carboxylic acid capable of forming an enzyme-stabilizing compound. An enzyme-stabilized formulation is disclosed comprising an alpha-hydroxy-mono-carboxylic acid or the salt of an alpha-hydroxy-mono-carboxylic acid, a boron containing compound capable complexing with an alpha-hydroxy-mono-carboxylic acid, the complex formed by the boron compound and the an alpha-hydroxy-mono-carboxylic acid, and an enzyme. The invention applies to both enzyme concentrate raw materials, and to useful product formulations.

Priority: US20040634564P Applic. Date: 2004-12-09

Inventor: LENOIR PIERRE M [CH]

Title: Cosmetic effervescent cleansing pillow with water soluble or dispersible packet

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC

Application No.: 11/009659   Filing Date: 10/Dec/2004

Abstract:A cleansing article is provided which includes an effervescent cleanser composition held within a water-soluble packet and the packet is held within a receptacle formed from a first and second substrate sheet. At least a portion of one of the substrate sheets must be water permeable. The effervescent cleanser composition is an intimate mixture of an acid material such as citric acid, an alkaline material such as sodium bicarbonate, and a surfactant.

Priority:

Inventor: ROSS MICHAEL E [US]; TURBETT JAMES L [US]; LAGATOL SHAUNA M [US]

Title: Triazole substituted aminobenzophenone compounds

Applicant/Assignee: LEO PHARMA A/S

Application No.: 11/292064   Filing Date: 02/Dec/2005

Abstract:The invention relates to novel compounds according to formula Ia and Ib, said compounds being useful, e.g. in the treatment of inflammatory, ophthalmic diseases, or cancer.

Priority: US20040635000P Applic. Date: 2004-12-13

Inventor: ERIK RYTTER OTTOSEN [DK]

Title: Thiazole derivatives

Applicant/Assignee: FUJISAWA PHARMACEUTICAL CO. LTD

Application No.: 11/345492   Filing Date: 02/Feb/2006

Abstract:A compound of the formula (I): R<1>-NH-X-Y-Z (I) wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof useful as a vascular adhesion protein-1 (VAP-1) inhibitor, a pharmaceutical composition, a method for preventing or treating a VAP-1 associated disease, especially macular edema, which method includes administering an effective amount of the compound or a pharmaceutically acceptable salt thereof to a mammal, and the like.

Priority: US2004-764529 Applic. Date: 2004-01-27; US20030442509P Applic. Date: 2003-01-27; US20030458369P Applic. Date: 2003-03-31; US20030517377P Applic. Date: 2003-11-06

Inventor: INOUE TAKAYUKI [JP]; TOJO TAKASHI [JP]; MORITA MASATAKA [JP]; OHKUBO MITSURU [JP]; YOSHIHARA KOUSEI [JP]; NAGASHIMA AKIRA [JP]

Title: Systems for and methods of atrioventricular valve regurgitation and reversing ventricular remodeling

Applicant/Assignee:

Application No.: 10/519585   Filing Date: 27/Jun/2003

Abstract:Methods of and devices for restoring the normal geometry of a heart, including but not limited to the structures supporting the atrioventricular valves. The techniques and devices described herein operate on the principle of displacement, both active and passive, to reverse cardiac remodeling and limit ischemic atrioventricular valve regurgitation.

Priority: US20020392332P Applic. Date: 2002-06-27; WO2003US20450 Applic. Date: 2003-06-27

Inventor: LEVINE ROBERT A [US]; HUNG JUDY W [US]; GUERRERO J LUIS [US]; VLAHAKES GUS J [US]

Title: Active muscle display device

Applicant/Assignee: NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY

Application No.: 10/527087   Filing Date: 14/Nov/2005

Abstract:In order to provide an active muscle display unit that extracts a firing pattern of the individual motor unit without applying a load to living organisms and display the extracted motor unit, the active muscle display unit comprises multiple electrodes 1 that are arranged on a skin surface, a surface electromyogram measuring part 32 that measures a surface electromyogram on the skin surface at the multiple electrodes 1, a motor unit separating part 33 that estimates the individual motor unit constituting an active muscle based on the surface electromyogram measured by the surface electromyogram measuring part 32, a motor unit position estimating part 35 that estimates a three-dimensional position of the firing motor unit based on the motor unit estimated to be the firing motor unit by the motor unit separating part 33,

and a display part 38 that displays the motor unit estimated by the motor unit position estimating part 35 in an image.

Priority: WO2002JP09302 Applic. Date: 2002-09-11

Inventor: MAEKAWA SATOSHI [JP]; FUJIWARA YOSHIHISA [JP]; KOTANI MANABU [JP]; ARIMOTO TAKAHIKO [JP]; KOTANI HIROKO [JP]

Title: Cosmetic composition comprising a sequenced polymer and a plasticizer

Applicant/Assignee:

Application No.: 10/529318   Filing Date: 25/Mar/2005

Abstract:A subject matter of the invention is a cosmetic composition comprising a cosmetically acceptable organic liquid medium, a block polymer and a plasticizer, characterized in that: the block polymer is a film-forming linear ethylenic polymer, the plasticizer is a compound, the nature and the amount of which are such that the composition is capable of forming a film having a hardness of less than or equal to 35 seconds, the hardness of the film being measured using a Persoz pendulum according to Standard NF-T-30-016, and in particular a compound having a solubility parameter deltah ranging from 5.5 to 11 (J/cm<3>)<1/2>. Application to making-up and caring for keratinous substances, in particular the skin.

Priority: FR20020011949 Applic. Date: 2002-09-26; FR20020016437 Applic. Date: 2002-12-20; FR20030006121 Applic. Date: 2003-05-21; WO2003FR02844 Applic. Date: 2003-09-26

Inventor: BLIN XAVIER [FR]; FERRARI VERONIQUE [FR]

Title: Personal care and household compositions of hydrophobically-modified polysaccharides

Applicant/Assignee:

Application No.: 11/300628   Filing Date: 14/Dec/2005

Abstract:A conditioning composition is used in functional systems (personal care and household care compositions) that has a nonionic hydrophobically modified cellulose ether (HMCE) having a weight average molecular weight (Mw) with a lower limit of 400,000 and an upper limit of 2,000,000 and a hydrophobic substitution lower limit of 0.6 wt % and an upper limit amount which renders said cellulose ether insoluble in a 5 wt % solution of surfactant and less than 0.05% by weight soluble in water and wherein the cellulose ether provides conditioning benefit to the functional system substrate. This composition has at least one active functional system ingredient.

Priority: US20040636682P Applic. Date: 2004-12-16

Inventor: BAKEEV KIRILL N [US]; ERAZO-MAJEWICZ PAQUITA [US]; MODI JASHAWANT J [US]; NGUYEN TUYEN T [US]; RMAILE HASSAN H [US]

Title: Antioxidative composition and composition for external use

Applicant/Assignee:

Application No.: 10/543529   Filing Date: 13/Sep/2005

Abstract:As a technical means of enabling the application of a fullerene and an analogue thereof in various fields relating to biocompatibility to achieve a novel function, in particular as a means of applying the same to a cosmetic product, a formulated skin preparation for external use or the like, an antioxidative composition comprising as an active ingredient at least one kind of a fullerene, a fullerene-containing oxygen derivative and the fullerene and the fullerene-containing oxygen derivative modified with or clathrated in an organic compound is prepared.

Priority: JP20030017866 Applic. Date: 2003-01-27; JP20030086523 Applic. Date: 2003-02-20; WO2004JP00699 Applic. Date: 2004-01-27

Inventor: ITO SHINOBU [JP]; MATSUBAYASHI KENJI [JP]

Title: CD55-Interaction partners and the uses thereof

Applicant/Assignee: CANCER REASEARCH TECHNOLOGY LIMITED

Application No.: 10/536636   Filing Date: 22/Aug/2005

Abstract:The invention relates to the use of a binding member which binds to both SCR1 and SCR2 of CD55 in the treatment of tumours and leukaemia. The binding member may be an antibody which binds to SCR1 and SCR2 of CD55 and neutralising CD55 and making cancer cells susceptible to complement mediated attack.

Priority: GB20020027644 Applic. Date: 2002-11-27; WO2003GB05163 Applic. Date: 2003-11-26

Inventor: DURRANT GILLIAN L [GB]

Title: Compositions and methods for treating tumor spreading

Applicant/Assignee:

Application No.: 10/902878   Filing Date: 02/Aug/2004

Abstract:Pharmaceutical compositions, each consisting of a cell-permeable fusion protein conjugate of a polypeptidic cell-membrane transport moiety and a Clostridium botulinum C3 exotransferase unit, or a functional analog thereof, are provided. The compositions are useful to prevent or inhibit uncontrolled proliferation, spreading, and migration of a metastatic neoplastic cell of a cancer in a mammal. The compositions can each effect or arrest combination of two or more of tumor cell proliferation, migration, angiogenesis, and metalloproteinase secretion.

Priority: US20030506162P Applic. Date: 2003-09-29; US2002-118079 Applic. Date: 2002-04-09; CA20022367636 Applic. Date: 2002-01-15; CA20012362004 Applic. Date: 2001-11-13; CA20012342970 Applic. Date: 2001-04-12

Inventor: LASKO DANA [CA]; MCKERRACHER LISA [CA]

Title: Novel sulfamide derivatives and cosmetic use thereof

Applicant/Assignee: L'OREAL

Application No.: 11/289551   Filing Date: 30/Nov/2005

Abstract:The present invention relates to the cosmetic use of a compound of formula (I) and also the cosmetically acceptable salts thereof, solvates thereof and isomers thereof, for non-therapeutic skincare. The invention also relates to compounds of general formula (II)

Priority: FR20040052821 Applic. Date: 2004-11-30; US20040638371P Applic. Date: 2004-12-27

Inventor: MARAT XAVIER [FR]; MULLER BENOIT [FR]

Title: Compositions and methods of their use for improving the condition and appearance of skin

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 11/021242   Filing Date: 22/Dec/2004

Abstract:The present invention relates to compositions and methods for treating, preventing and improving the condition and/or aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, where the compositions include active agents which increase expression levels of genes associated with the dermatological signs of aging. The compositions of the invention are topically applied to the skin, or are delivered by directed means to a site in need thereof, once daily in an amount effective in improving the condition and/or aesthetic appearance of skin.

Priority:

Inventor: DRYER LAURENCE [US]; PTCHELINTSEV DMITRI [US]

Title: Method for caring for the skin and associated kit

Applicant/Assignee: L'OREAL

Application No.: 11/287420   Filing Date: 28/Nov/2005

Abstract:The present invention relates to a method for caring for the skin, intended to soften cutaneous signs of ageing, by the successive application to the skin, wetted beforehand, of four compositions, namely: a microdermabrasion composition, a peeling composition, a soothing composition and an anti-ageing composition having a given constitution. It also relates to a kit having four separate packagings, each of which includes one of the abovementioned compositions.

Priority: FR20040053043 Applic. Date: 2004-12-17; US20050663202P Applic. Date: 2005-03-21

Inventor: MARION CATHERINE [FR]

Title: Oxygenating agents for enhancing host responses to microbial infections

Applicant/Assignee:

Application No.: 10/509285   Filing Date: 27/Jun/2005

Abstract:Oxygenating agents are used in the present invention for the novel purpose of treating microbial infections. The invention takes advantage of the fact that the increase in tissue pO2 produced thereby can enhance the efficacy of the body's own antimicrobial defenses (including tissue repair), while also improving the efficacy of adjunctive agents that may be co-administered, such as antimicrobial agents, antioxidants, cytokine modulators, endotoxin antagonists and growth factors. The oxygenating agents of the present invention achieve the desired increased pO2 in the tissues without having to resort to the risks and expenses of hyper-baric oxygen therapy (HBO). The oxygenating agents can be administered systemically, regionally, or topically.

Priority: US20020367732P Applic. Date: 2002-03-28; WO2003US09226 Applic. Date: 2003-03-26

Inventor: CARLTON RICHARD M [US]; GALPIN JEFFREY E [US]

Title: Methods for producing block copolymer/amphiphilic particles

Applicant/Assignee: VICAL INCORPORATED

Application No.: 11/292280   Filing Date: 02/Dec/2005

Abstract:The invention relates to a method for manufacturing cell delivery particles, pharmaceutical component-particle dispersions, compositions comprising cell delivery particles and pharmaceutical compositions comprising pharmaceutical component-particle dispersions. The method comprises homogenization of mixtures comprising amphiphilic components and a block copolymer to form stable particles. The invention is also directed to cell delivery particles and pharmaceutical component-particle dispersions produced by the claimed methods and compositions comprising same. In certain embodiments, the cell delivery particles may further comprise co-lipids. The invention further relates to methods of generating an immune response, treating or preventing a disease or condition, or delivering a biologically active molecule to cells in vitro comprising administration of the pharmaceutical compositions described herein.

Priority: US20040632612P Applic. Date: 2004-12-03

Inventor: GEALL ANDREW [US]

Title: Reduced odor toilet bar composition

Applicant/Assignee: UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO., INC

Application No.: 11/151112   Filing Date: 13/Jun/2005

Abstract:Toilet bar compositions are described that contain specific odor masking agent(s). The odor masking agent(s) reduce malodor without the need for elevated amounts of masking fragrances that individuals may not prefer and who use the composition for personal cleansing or who are exposed to the composition.

Priority: US2004-019794 Applic. Date: 2004-12-22

Inventor: MASSARO MICHAEL [US]; MERAVIGLIA SANDRA D [US]; ABBAS SYED H [US]; KHARA BIPINCHANDRA J [US]; SHEVADE MAKARAND S [US]; VAN VLIJMEN MICHAEL B [US]

Title: Cleansing composition in the form of an aerosol foam without anionic surfactant, and uses in cosmetics

Applicant/Assignee: L'OREAL S.A

Application No.: 11/287298   Filing Date: 28/Nov/2005

Abstract:The present disclosure relates to foaming cleansing compositions without anionic surfactant, comprising, in a cosmetically acceptable medium: a) greater than 2% by weight in terms of active material of a non-betaine amphoteric or zwitterionic surfactant, relative to the total weight of the composition, b) at least one non-ionic surfactant, c) at least one propellant. The present disclosure also relates to aerosol devices containing such a composition and also to the use of these compositions in cosmetics or dermatology, for instance for cleansing keratin materials such as the skin, the hair or the scalp.

Priority: FR20040052773 Applic. Date: 2004-11-26; US20040635960P Applic. Date: 2004-12-15

Inventor: RIBERY DELPHINE [FR]; PENVERNE ISABELLE [FR]

Title: Liquid cleansing composition comprising at least one anionic surfactant and its use for cleansing human keratin materials

Applicant/Assignee: L'OREAL S.A

Application No.: 11/287300   Filing Date: 28/Nov/2005

Abstract:The present disclosure relates to a liquid cleansing composition, comprising, in a cosmetically acceptable aqueous medium: (a) at least one anionic surfactant

(b) at least one electrolyte, (c) at least one copolymer of methacrylic acid and of a C1-C4 alkyl acrylate, present in an amount of less than 0.5% by weight of active material, relative to the total weight of the composition. The present disclosure also relates to the use of the compositions in cosmetics or dermatology, such as products for cleansing human keratin materials, for instance the skin, and to their use for improving the stability of the texture of the composition at low temperature.

Priority: FR20040052780 Applic. Date: 2004-11-26; US20040634542P Applic. Date: 2004-12-10

Inventor: BISSEY-BEUGRAS LAURE [FR]; RIBERY DELPHINE [FR]

Title: Methods of treating tumors

Applicant/Assignee:

Application No.: 11/350313   Filing Date: 07/Feb/2006

Abstract:The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.

Priority: US2002-301263 Applic. Date: 2002-11-21; US2000-730666 Applic. Date: 2000-12-06; US19990169122P Applic. Date: 1999-12-06; US19990169127P Applic. Date: 1999-12-06; US19990169128P Applic. Date: 1999-12-06

Inventor: CALABRESI PAUL [US]; DARNOWSKI JAMES [US]

Title: Method and compounds for promoting healing and reducing inflammation

Applicant/Assignee:

Application No.: 10/519645   Filing Date: 22/Sep/2005

Abstract:This invention relates to methods of promoting healing and reducing inflammation, and compositions therefore. In particular, the invention relates to the use of 1,3-dialkyl-4,5-bis(N-methylcarbamoyl)imidazolium salts to promote wound healing and to reduce inflammation. Novel compounds and compositions are also provided. In one preferred embodiment the invention provides a method of treatment of myocardial infarction.

Priority: RU20020120366 Applic. Date: 2002-08-01; WO2003AU00972 Applic. Date: 2003-07-31

Inventor: SAPRONOV NIKOLAY S [RU]; PIOTROVSKY LEVON B [RU]; GAVROVSKAYA LUIDMILA K [RU]

Title: Novel compounds for use in the treatment of autoimmune diseases, immuno-allergical diseases and organ or tissue transplantation rejection

Applicant/Assignee: NOVAREMED LIMITED

Application No.: 10/530116   Filing Date: 29/Nov/2005

Abstract:The present invention provides compounds, pharmaceutical compositions and methods for treating, immuno-allergical diseases, autoimmune diseases, and organ or tissue rejection following transplantation.

Priority: US20020415508P Applic. Date: 2002-10-03; WO2003IB04993 Applic. Date: 2003-10-01

Inventor: KAPLAN ELIAHU [IL]

Title: Low peak exotherm curable compositions

Applicant/Assignee:

Application No.: 11/214207   Filing Date: 29/Aug/2005

Abstract:Compositions having a curable unsaturated compound, an adhesion promoter and curing agent which have a peak exotherm of less than 50.degree. C. are disclosed. The compositions when cured are flexible bioadhesives which are also disclosed. Non-curable diluents can be included in the compositions. Flexible bioadhesives formed on biological structures and having low peak exotherms upon curing of curable compositions to form the flexible bioadhesives are disclosed. Compositions having a curable unsaturated compound and a curing agent and a peak exotherm of less than 50.degree. C. are included in the invention.

Priority: US2004-925583 Applic. Date: 2004-08-25; US2000-552994 Applic. Date: 2000-04-21

Inventor: MONTGOMERY ROBERT E [US]; CIPOLLA ANTHONY J [US]

Title: Iontophoretic device and method for administering immune response-enhancing agents and compositions

Applicant/Assignee:

Application No.: 11/280805   Filing Date: 16/Nov/2005

Abstract:An iontophoresis device and method delivers an immune response-enhancing agent, or composition thereof via iontophoresis. The device may include an active electrode assembly having a drug solution holding portion, comprising an immune response-enhancing agent, or composition thereof

and a non-active electrode assembly. An iontophoresis device delivers an immune response-enhancing agent via iontophoresis. The device includes an active electrode assembly and a non-active electrode assembly, wherein the active electrode assembly comprises: a first electrode element operable to provide an electrical potential of a first polarity and a drug solution holding portion arranged on a front surface of the first electrode member.

Priority: US20040627952P Applic. Date: 2004-11-16; US20050714538P Applic. Date: 2005-05-16; US2005-129321 Applic. Date: 2005-05-16

Inventor: MATSUMURA AKIHIKO [JP]; REED STEVEN G [US]

Title: Olefin wax, silicone-modified olefin waxes, silicone-base cold-setting compositions made by using the same, and cosmetics containing the same

Applicant/Assignee: SHIN-ETSU CHEMICAL CO. LTD

Application No.: 10/531377   Filing Date: 26/Sep/2005

Abstract:An olefin wax (A) is (i) a copolymer (A1) obtained by copolymerizing ethylene and at least one diene or a copolymer (A2) obtained by copolymerizing ethylene, at least one olefin selected from alpha-olefins of 3 to 12 carbon atoms and at least one diene

wherein (ii) the content of unsaturated groups per one molecule is in the range of 0.5 to 3.0 groups

(iii) the density is in the range of 870 to 980 kg/m<3>

(iv) the melting point is in the range of 70 to 130 DEG C.

(v) the number-average molecular weight is in the range of 400 to 5,000

and (vi) the ratio (Mw/Mn) of the weight-average molecular weight to the number-average molecular weight is not more than 4.0. A silicone-modified olefin wax can be obtained by reacting hydrogen silicone with the olefin wax (A). Cosmetics contain the silicone-modified olefin wax.

Priority: JP20020302202 Applic. Date: 2002-10-16; WO2003JP13265 Applic. Date: 2003-10-16

Inventor: TOYODA HIDEO [JP]; UOSAKI HIROTAKA [JP]; KAN KOUJIRO [JP]; ICHINOHE SHOJI [JP]; SHIMIZU TORU [JP]

Title: Cosmetic and pharmaceutical foam

Applicant/Assignee: FOAMIX LTD

Application No.: 10/532618   Filing Date: 22/Dec/2005

Abstract:The invention relates to an alcohol-free cosmetic or pharmaceutical foam carrier comprising water, a hydrophobic solvent, a foam adjuvant agent, a surface-active agent and a water gelling agent. The cosmetic or pharmaceutical foam carrier does not contain aliphatic alcohols, making it non-irritating and non-drying. The alcohol-free foam carrier is suitable for inclusion of both water-soluble and oil soluble pharmaceutical and cosmetic agents.

Priority: IL20020152486 Applic. Date: 2002-10-25; US20020429546P Applic. Date: 2002-11-29; WO2003IB05527 Applic. Date: 2003-10-24

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; EINI MEIR [IL]

Title: Methods for treating ectoparasite infections on the mammalian body

Applicant/Assignee:

Application No.: 10/519372   Filing Date: 23/Dec/2004

Abstract:Methods for treating ectoparasites, their nymphs, and their egg infestations on animal skin and hair, wherein the compositions used in the methods contain at least one monohydric aralkyl alcohol in a quantity sufficient to provide pesticidal activity

the compositions are applied to the infected areas in a quantity sufficient to completely saturate both the hair and the skin in the infected areas with the composition

and the compositions can be readily washed out of the infected areas by rinsing with water.

Priority:

Inventor: PRECOPIO MICHAEL J [US]

Title: Particles for the delivery of active agents

Applicant/Assignee: IVREA PHARMACEUTICALS, INC

Application No.: 11/283064   Filing Date: 17/Nov/2005

Abstract:Formulations of active agent particles of less than 100 microns in a droplet of dispersant, which is coated with a matrix of cationic and anionic polymers, are efficient vehicles for delivering active agents to tissues such as skin and mucosal membranes. Such formulations are able to deliver compounds to skin with little associated irritation. Prior art topical formulations typically have the disadvantage of causing significant skin irritation.

Priority: US2005-123958 Applic. Date: 2005-05-06; US2004-839907 Applic. Date: 2004-05-06; US20040634885P Applic. Date: 2004-12-09

Inventor: CATTANEO MAURIZIO V [US]

Title: Composition comprising a rice protein hydrolysate and an agent for increasing glycosaminoglycan synthesis

Applicant/Assignee: L'OREAL

Application No.: 11/266287   Filing Date: 04/Nov/2005

Abstract:The present invention relates to a process for preventing and/or reducing the signs of ageing of the skin, in particular for remodelling the face and/or limiting the age-related hollowing of the face, by applying to facial skin a composition containing, in a physiologically acceptable medium, at least one rice protein hydrolysate and at least one agent for increasing glycosaminoglycan synthesis.

Priority: FR20040052593 Applic. Date: 2004-11-10; US20050643172P Applic. Date: 2005-01-13

Inventor: GUILLOU VERONIQUE [FR]; THIRY ANNABELLE [FR]

Title: Promotion of peroxisomal catalase function in cells

Applicant/Assignee: WAYNE STATE UNIVERSITY

Application No.: 10/533124   Filing Date: 27/Dec/2005

Abstract:The molecular mechanisms of peroxisome biogenesis have begun to emerge: in contrast, relatively little is known about how the organelle functions as cells age. The present inventors characterized age-related changes in peroxisomes of human cells and showed that aging compromises peroxisomal targeting signal 1 (PTS1) protein import, with the critical antioxidant enzyme, catalase, especially affected. The number and appearance of peroxisomes are altered in these cells, and the organelles accumulate the PTS1-import receptor. Pex5p, on their membranes. Concomitantly, cells produce increasing amounts of the toxic metabolite, H2O2, and this increased load of reactive oxygen species (ROS) may further reduce peroxisomal protein import and exacerbate the effects of aging.

Disclosed are novel compositions and methods for restoring catalase in peroxisomes by use of targeted catalase modified at its C-terminus and/or N-terminus, optionally in combination with polypeptides which promote cellular uptake of proteins, to prevent or overcome the changes that follows aging or that are associated with a number of diseases or disorders.

Priority: US20020422100P Applic. Date: 2002-10-30; WO2003US34512 Applic. Date: 2003-10-30

Inventor: TERLECKY STANLEY R [US]; WALTON PAUL A [CA]

Title: Compositions and methods comprising protein activated receptor antagonists

Applicant/Assignee:

Application No.: 10/608886   Filing Date: 26/Jun/2003

Abstract:Compositions and methods comprising protein activated receptor antagonists are provided More particularly, the present invention relates to the use of proteins, peptides and biomolecules that bind to protein activated receptor 2, and inhibit the processes associated with the activation of that receptor. More specifically, the present invention provides novel compositions and methods for the treatment of disorders and diseases such as those associated with abnormal cellular proliferation, angiogenesis, inflammation and cancer.

Priority: US20020391655P Applic. Date: 2002-06-26; US20020398662P Applic. Date: 2002-07-26; US20030458095P Applic. Date: 2003-03-27; US20030466296P Applic. Date: 2003-04-29

Inventor: HEMBROUGH TODD [US]; PRIBLUDA VICTOR [US]

Title: Method for treating or preventing pruritic and neurogenic skin disorders

Applicant/Assignee:

Application No.: 11/315773   Filing Date: 22/Dec/2005

Abstract:This invention relates to methods of treatments, compositions, and kits for providing rapid relief to the user for pruritic and neurogenic skin disorders. The invention also provides methods of treatments, compositions, and kits for preventing such conditions.

Priority: US20040639382P Applic. Date: 2004-12-27

Inventor: SOUTHALL MICHAEL [US]; LIEBEL FRANK [US]

Title: Medicaments for the Treatment or Prevention of Fibrotic Diseases

Applicant/Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Application No.: 11/275223   Filing Date: 20/Dec/2005

Abstract:The present invention relates to the use of indolinones of general formula substituted in the 6 position, wherein R1 to R5 and X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, as a medicament for the prevention or treatment of specific fibrotic diseases.

Priority: EP20040030770 Applic. Date: 2004-12-24

Inventor: PARK JOHN E [DE]; ROTH GERALD J [DE]; HECKEL ARMIN [DE]; CHAUDHARY NVEED [DE]; BRANDL TRIXI [DE]; DAHMANN GEORG [DE]; GRAUERT MATTHIAS [DE]

Title: Animal model for the fast identification of pharmaceutical active compounds in vivo

Applicant/Assignee: JANSSEN PHARMACEUTICA N.V

Application No.: 10/547518   Filing Date: 03/Mar/2004

Abstract:In a first aspect the present invention provides a tumor cell line stably transfected with an expression vector containing a reporter gene, preferably a fluorescent protein, operably linked to a promotor that also controls expression of a protein that is associated with tumor regression, stabilisation of tumor growth or inhibition of metastatic growth, characterised in that said cell line is capable to form a tumor when implanted or injected into the non-human animal. Compared to the traditional in vivo models, the present invention differs in that the reporter gene is not constitutively expressed, but only after exposure to a test compound that results in the expression of a protein or enzyme associated with tumor regression, stabilisation of tumor growth or inhibition of metastatic growth.

Only when a compound to be tested got into circulation and infiltrated the tumor it may generate the reporter signal, provided it promotes the expression of a protein associated with tumor regression and the promoter of said protein is operably linked to the reporter gene.

Priority: WO2003EP02264 Applic. Date: 2003-03-05; WO2004EP02195 Applic. Date: 2004-03-03

Inventor: BELIEN ANN T J [BE]; ARTS JANINE [BE]; MARIEN ANN O A [BE]; VALCKX ANNEMIE F [BE]

Title: Sprayable compositions comprising pharmaceutical active agents, volatile silicones and a non-volatile oily phase

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT, S.N.C

Application No.: 11/315259   Filing Date: 23/Dec/2005

Abstract:Compositions in the form of a spray contain a pharmaceutical active agent, at least one volatile silicone and a non-volatile oily phase, formulated into a physiologically acceptable medium, are well suited for improved transdermal administration in cosmetics and dermatology.

Priority: FR20030007551 Applic. Date: 2003-06-23; WO2004EP07203 Applic. Date: 2004-06-18

Inventor: MALLARD CLAIRE [FR]; PITRE FRANCK [FR]; FREDON LAURENT [FR]

Title: Composition containing ascorbic acid

Applicant/Assignee: L'OREAL

Application No.: 11/322216   Filing Date: 03/Jan/2006

Abstract:The invention relates to a composition in oil-in-water emulsion form containing ascorbic acid or a derivative thereof, at least one polysaccharide hydrophilic gelling agent, at least one C16-C22 fatty acid sorbitan ester, at least one ethoxylated fatty acid ester and at least one polymer containing a sulpho-functional monomer.

Priority: FR20050050008 Applic. Date: 2005-01-03; US20050641741P Applic. Date: 2005-01-07

Inventor: MONELLO ALDO [FR]

Title: Non-transfer cosmetic composition comprising a sequenced polymer

Applicant/Assignee: L'OREAL C.A

Application No.: 10/529264   Filing Date: 19/Dec/2005

Abstract:The invention relates to a cosmetic composition comprising at least one cosmetically acceptable organic liquid medium and at least one film-forming linear block ethylenic polymer, the said polymer being such that, when it is present in sufficient amount in the composition, the said composition is capable of forming a deposit that has a transfer of less than or equal to 35%. Application to making up and caring for keratin materials, especially the skin and the lips.

Priority: FR20020011949 Applic. Date: 2002-09-26; FR20020016437 Applic. Date: 2002-12-20; FR20030006121 Applic. Date: 2003-05-21; WO2003FR02845 Applic. Date: 2003-09-26

Inventor: FERRARI VERONIQUE [FR]; BLIN XAVIER [FR]; LION BERTRAND [FR]

Title: Adipose-derived stem cells for tissue regeneration and wound healing

Applicant/Assignee: PRIMEGEN BIOTECH LLC

Application No.: 11/323276   Filing Date: 30/Dec/2005

Abstract:Compositions and methods for promoting tissue regeneration, particularly skin regeneration, with adipose-derived stem cells are provided. Additionally methods and compositions for promoting tissue regeneration with adipose-derived stem cell side population cells are provided. The adipose-derived cells are administered in a tissue regenerating effect amount optionally with a bioactive agent. Additionally the adipose derived cells can be autologous or syngeneic.

Priority: US20040641034P Applic. Date: 2004-12-30

Inventor: SAYRE CHAUNCEY B [US]; SILVA FRANCISCO J [US]

Title: Agent and compositions comprising the same for inhibiting lipases and phospholipases in body fluids, cells and tissues

Applicant/Assignee: RELIANCE LIFE SCIENCES PVT. LTD RELIANCE LIFE SCIENCE PVT. LTD

Application No.: 11/093637   Filing Date: 30/Mar/2005

Abstract:The present invention deals with a protein and compositions comprising the same for inhibition of lipases and phospholipases in the body fluids, cells, and tissues for the prevention and treatment of metabolic syndrome, cardiovascular disorders, and inflammatory diseases. The protein is either isolated from plant species or synthesized or produced by recombinant DNA technology.

Priority: US20040557624P Applic. Date: 2004-03-30

Inventor: UPADHYAY SHAKTI N [IN]; YADAV RAMAN P [IN]; ANSARI ARIF [IN]; RAO S HARINARAYANA [IN]

Title: Concurrent Enhancement of Skin Penetration of Organic Base Active Agents and Organic Hydroxy Acid Active Agents as Their Ion-Pair Complexes

Applicant/Assignee: BIODERM RESEARCH

Application No.: 11/307729   Filing Date: 18/Feb/2006

Abstract:This invention relates to concurrent enhancement of skin penetration of certain organic nitrogen heterocyclic base active agents and certain organic acid active agents, especially organic hydroxy acids. This concurrent enhancement of skin penetration also provides enhanced bioavailability of both organic nitrogen heterocyclic base active agent and organic hydroxy acid active agent. The organic nitrogen heterocyclic base active agents and organic hydroxy acid active agents are first combined to form an ion-pair complex, which includes an in-situ mixing process, and said ion-pair complex is applied topically, whereupon said ion-pair complex undergoes enhanced skin penetration and upon reaching uppermost living part of skin and having reached therein the physiological pH of 7.4, said ion-pair complex dissociates to release its constituent organic nitrogen heterocyclic base active agent and said organic acid active agent in a bioavailable form.

Priority: US2002-265000 Applic. Date: 2002-10-04; US2002-290933 Applic. Date: 2002-11-07; US2002-280519 Applic. Date: 2002-10-25; US2003-439349 Applic. Date: 2003-05-15; US2003-394851 Applic. Date: 2003-03-22

Inventor: GUPTA SHYAM K [US]

Title: Method for treating non-neuropathic pain

Applicant/Assignee: ENDO PHARMACEUTICALS, INC

Application No.: 11/336001   Filing Date: 20/Jan/2006

Abstract:A method including topically administering an effective amount of local anesthetic to a patient is disclosed. The method is effective for inducing analgesia for treating non-neuropathic pain. Non-neuropathic pain suitable for treatment according to the invention includes pain associated with sports injuries

sprains

strains

soft-tissue injury

repetitive motion injury

carpal tunnel syndrome

injury to tendons, ligament, and muscles

conditions such as fibromyalgia, bursitis, castrochondritis, myofascial pain, and pain associated with arthritis, inflammation, contusions, post-surgical pain, and nociceptive pain. Preferably, the lidocaine is applied via a transdermal patch applied near the locus of pain.

Priority: US2001-045341 Applic. Date: 2001-10-25

Inventor: GALER BRADLEY S [US]

Title: Peptidic sulfonamides

Applicant/Assignee: MERCK PATENT GMBH

Application No.: 10/544625   Filing Date: 05/Aug/2005

Abstract:The invention relates to novel peptides which are biologically active as ligands of blood platelet integrin GPIIbIIIa and the alphav integrins, preferably the alphavbetas and alphavbeta3 integrin, having the formula (I): R<1>-Arg-X-Asp-Leu-Asp-Ser-Leu-Arg-R<2 >(I), in which R<1 >denotes H, acetyl or acyl and R<2 >denotes -Oh, OR<3 >NH2,NHR<3>, N(R<3>)2 R<3 >denotes atkyl, aralkyl, aryl, Het and X denotes an amino acid of the formula (II), in which A denotes (CH2)n R<4 >denotes H, alkyl, aralkyl or aryl, and n denotes 1, 2, 3, 4, 5 or 6, and the amino acid of the formula (II) is bonded to the adjacent Arg via a peptide bond of the alpha-amino group and to the alpha-amino group of the adjacent Asp via a peptide bond of the alpha-carboxyl group.

Priority: EP20030002556 Applic. Date: 2003-02-06; WO2004EP00211 Applic. Date: 2004-01-14

Inventor: JONCZYK ALFRED [DE]; GROTH ULRICH [DE]; ZISCHINSKY GUNTHER [DE]

Title: Medicaments for the Treatment or Prevention of Fibrotic Diseases

Applicant/Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Application No.: 11/275226   Filing Date: 20/Dec/2005

Abstract:The present invention relates to the use of indolinones of general formula substituted in the 6 position, wherein R1 to R6 and X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, as a medicament for the prevention or treatment of specific fibrotic diseases.

Priority: EP20040030769 Applic. Date: 2004-12-24

Inventor: PARK JOHN E [DE]; CHAUDHARY NVEED [DE]; ROTH GERALD J [DE]; HECKEL ARMIN [DE]; LEHMANN-LINTZ THORSTEN [DE]; KLEY JOERG [DE]

Title: Capsaicinoid gel formulation and uses thereof

Applicant/Assignee: ALGORX PHARMACEUTICALS, INC

Application No.: 11/286059   Filing Date: 23/Nov/2005

Abstract:The present invention provides capsaicinoid gel formulations and methods for relieving pre- and post-surgical pain at a site in a human or animal by administering at a surgical site in a human or animal in need thereof a dose of capsaicinoid gel in an amount effective to attenuate post-surgical pain at the surgical site, the dose of capsaicin ranging from 100 mug to 10,000 mug.

Priority: US20040630577P Applic. Date: 2004-11-24

Inventor: BURCH RONALD M [US]; ANDERSON TIMOTHY A [US]; LAZAR JEFF [US]

Title: Enhanced efficacy antiperspirant active

Applicant/Assignee:

Application No.: 11/034477   Filing Date: 13/Jan/2005

Abstract:An enhanced efficacy aluminum only salt active. The method for making such active comprises the steps of (a) providing an aqueous solution of an aluminum salt having a Band III polymer concentration of at least about 20%

(b) adding to the aqueous solution of step (a) an aqueous solution of a monomeric aluminum salt to form a mixture

and (c) rapidly drying the mixture to form a product powder. The active comprises an aluminum only salt having a Band III polymer concentration of at least about 20%, an aluminum to anion ratio of from about 1.1:1 to about 1.8:1 and a level of monomeric aluminum of from about 2% to about 20% of the total aluminum.

Priority:

Inventor: SWAILE DAVID F [US]; BEIMESCH WAYNE E [US]; GOOD DAVID [US]; SMITH SCOTT E [US]

Title: Repeat sequence protein polymer active agent congjugates, methods and uses

Applicant/Assignee: GENENCOR INTERNATIONAL, INC

Application No.: 11/351712   Filing Date: 10/Feb/2006

Abstract:Biomolecular conjugates are provided which comprise the conjugation product of a repeat sequence protein polymer and at least one active agent. Additional aspects provide methods for their manufacture and various industrial and consumer applications.

Priority: US2004-845936 Applic. Date: 2004-05-14; US20030470464P Applic. Date: 2003-05-14

Inventor: COLLIER KATHERINE D [US]; CUEVAS WILLIAM A [US]; KUMAR MANOJ [US]

Title: Novel cosmetic formulations based on a gel-forming and/or thickening agent and applications of same

Applicant/Assignee:

Application No.: 10/530082   Filing Date: 08/Dec/2005

Abstract:The invention relates to the field of the necessities of life and more particularly to the field of cosmetics, hygiene and skin products. More specifically it relates to aqueous, fluid or gelled, cosmetic compositions intended to be applied to the skin, the mucous membranes or the teguments, characterized in that they contain, as active ingredient, a gelling and/or thickening agent formed from a combination of three constituents, namely a polyacrylamide and ammonium acrylate copolymer and/or an anionic acrylic copolymer, lecithins or phospholipids of plant origin, and a polyglyceryl acylate, in combination or in a mixture with excipients or appropriate vehicles for topical use. These compositions can incorporate other appropriate active ingredients in particular for use in cosmetics. Use in cosmetics or in skin products for the production of perfectly stable emulsions, gels, or creams.

Priority: FR20020012202 Applic. Date: 2002-10-02; WO2003FR02898 Applic. Date: 2003-10-02

Inventor: ARNAUD JEAN-PIERRE [FR]; LE FUR AGNES [FR]

Title: Aqueous polymer dispersion and use thereof in cosmetics

Applicant/Assignee: BASF AKTIENGESELLSCHAFT

Application No.: 10/564485   Filing Date: 13/Jul/2004

Abstract:The present invention relates to an aqueous polymer dispersion which is obtainable by free-radical polymerization of a monomer mixture which comprises at least one amide-group-containing compound, at least one crosslinker and at least one monomer with at least one cationogenic and/or cationic group. The invention further relates to the polymers obtainable by drying such a polymer dispersion, and to cosmetic or pharmaceutical compositions which comprise such a polymer dispersion or such a polymer.

Priority: DE20031031865 Applic. Date: 2003-07-14; WO2004EP07741 Applic. Date: 2004-07-13

Inventor: CHRISSTOFFELS LYSANDER [US]

Title: Cancer immunotherapy incorporating p53

Applicant/Assignee: INTROGEN THERAPEUTICS, INC

Application No.: 11/281922   Filing Date: 17/Nov/2005

Abstract:A method of stimulating an immune response to a tumor in an immunocompetent subject by administering a p53 expression construct to a tumor. The construct expresses p53 in tumor cells in an amount sufficient to stimulate an immune response against the tumor. Both viral and non-viral delivery systems are contemplated. The method can be combined with chemotherapy agents as well as with other cancer therapies.

Priority: US20040628990P Applic. Date: 2004-11-17

Inventor: CRISTOFANILLI MASSIMO [US]; KRISHNAMURTHY SAVITRI [US]; MENANDER KERSTIN [US]; HORTOBAGYI GABRIEL N [US]

Title: Ambiphilic porous matrix

Applicant/Assignee: PHARES PHARMACEUTICAL RESEARCH N.V

Application No.: 10/547193   Filing Date: 27/Feb/2004

Abstract:Compositions are described which are capable of forming external reservoirs comprising a polymeric matrix for adsorbing sebum in exchange for beneficial oils and transfer of hydrating components to the skin. The compositions may be lotions, creams, gels, pastes, lip sticks and water and oil systems. There is also described a method of preparing said lotions, creams, etc containing an ambiphilic powder mixture or complex comprising synthetic porous agglomerates, a lipophilic component, hydrophilioc attractant/polymer, optionally biologically active compound and excipients.

Priority: EP20030251212 Applic. Date: 2003-02-27; WO2004EP01985 Applic. Date: 2004-02-27

Inventor: LEIGH MATHEW L S [CH]; LEIGH STEVE [NL]; KUNG ELSA [CH]; VAN HOOGEVEST PETER [CH]

Title: Discontinuous surface coating for particles

Applicant/Assignee:

Application No.: 11/324943   Filing Date: 04/Jan/2006

Abstract:The present invention relates to particle compositions comprising a core particle that is partially coated with a first hydrophilic deposit and a hydrophobic polymeric finish, contains a small amount of water, and a compatible active present in the deposit, the finish or both. Additional alternating deposits, hydrophobic, hydrophilic or both, can be present between the first hydrophilic deposit and the hydrophobic polymeric finish. Similarly, additional compatible actives can be present in one or more of the additional alternating deposits. The invention also relates to methods of preparing the particle compositions.

Priority: US20050642721P Applic. Date: 2005-01-10

Inventor: FRIEL FRANCIS M [US]; LEE WILSON A [US]; SHIDARA AYA [US]; MERCADO CLARA G [US]; LEAVER ERIC J [US]

Title: Meta-stable insect repellent emulsion composition and method of use

Applicant/Assignee:

Application No.: 11/371582   Filing Date: 09/Mar/2006

Abstract:There is provided an improved insect repellent emulsion composition. The composition has an inner discontinuous phase and an outer continuous phase. The inner discontinuous phase and/or outer continuous phase has an insect repellent active therein. The inner discontinuous phase is generally dispersed in the outer continuous phase and is in the form of discrete droplets having a multimodal droplet size distribution. There is also provided a method of protecting skin from being bitten by insects in which the above composition is applied topically to the skin. There is also provided a method of enhancing the performance of a insect repellent emulsion by forming the inner discontinuous phase as a multiplicity of droplets having a multimodal droplet size distribution. There is also provided a method of preparing an emulsifier-free insect repellent composition.

Priority: US2002-334171 Applic. Date: 2002-12-30; US2001-032847 Applic. Date: 2001-12-26

Inventor: GONZALEZ ANTHONY D [US]; PECHKO ANDREW H [US]; POLYWODA VINCENT T [US]

Title: Compositions, products and methods for controlling weight in a mammal

Applicant/Assignee:

Application No.: 11/032341   Filing Date: 10/Jan/2005

Abstract:Compositions for controlling mammalian weight, said compositions comprising one or more lipolytic agents for stimulating mammalian lipolysis and/or thermogenic agents for modulating mammalian thermogenesis. Products, consumer and otherwise, comprising said compositions and methods of using both the present compositions and products to control mammalian weight.

Priority:

Inventor: BASCOM CHARLES C [US]; YOUNGQUIST ROBERT S [US]; WALANSKI AMY A [US]; HO BEGONIA Y [US]; FUENTES GARY R [US]

Title: Products comprising an applicator and lipid and aqueous phase

Applicant/Assignee:

Application No.: 10/521070   Filing Date: 08/Jul/2003

Abstract:This invention concerns products for cleansing and other applications, which products comprise an applicator such as a puff (pouf), pad, sponge, cotton ball, swab, brush glove, mitt or bar, to which a lipid and aqueous phase have been applied. The invention further concerns the manufacture and use of such products.

Priority: WO2003EP07397 Applic. Date: 2003-07-08

Inventor: HAUSER MATTHIAS [DE]; ANSMANN ACHIM [DE]; ISSBERNER ULRICH [DE]; JACKWERTH BETTINA [DE]; LEONARD MARK [GB]

Title: Beta sheet tapes ribbons in tissue engineering

Applicant/Assignee: UNIVERSITY OF LEEDS

Application No.: 10/521628   Filing Date: 08/Sep/2005

Abstract:There is described a material comprising ribbons, fibrils or fibres characterised in that each of the ribbons, fibrils or fibres have an antiparallel arrangement of peptides in a beta-sheet-tape-like substructure.

Priority: GB20020016286 Applic. Date: 2002-07-15; WO2003GB03016 Applic. Date: 2003-07-15