A1 Published: 2009-01-01

Title: PERSONAL CARE PRODUCT HAVING A SOLID PERSONAL CARE COMPOSITION WITHIN A STRUCTURE MAINTAINING DISPENSER

Application No.: US2008-0037536 Applic. Date: 2008-02-26

Abstract: A personal care product is disclosed comprising a personal care composition and a dispensing container having the personal care composition disposed therein. The personal care composition may have a pre-dispense G' of at least about 5,000 Pa. The personal care product provides a G' preservation percentage of no less than 10%. The dispensing container may comprise a container body having a storage void containing the personal care composition, a movable partition at least partially disposed within the storage void, a drive mechanism connected to and able to advance the movable partition, and a dispensing plate joined to the container body. The dispensing plate has an orifice through which the personal care composition is dispensed. The orifice may have an inscribed circle diameter of about 1 mm to about 12 mm.

Priority: US2008-0037536 Applic. Date: 2008-02-26; US2007-0903634P Applic. Date: 2007-02-27

Inventor: ZUKOWSKI JOSEPH MICHAEL (US); LEPPLA NANCY LORINCZ (US); ZHU CHU (US); CILLEY ANN MARIE (US); BREYFOGLE LAURIE ELLEN (US)

A1 Published: 2009-01-01

Title: Dispersions of polymers in organic medium, and compositions comprising them

Applicant: OREAL (FR)

Application No.: US2008-0218391 Applic. Date: 2008-07-15

Abstract: The invention relates to self-stabilized dispersions of polymer particles in a non-aqueous non-silicone medium, and to a process for preparing the said polymers. The invention also relates to cosmetic or pharmaceutical compositions comprising the said polymer particle dispersions.

Priority: US2008-0218391 Applic. Date: 2008-07-15; FR2002-0015737 Applic. Date: 2002-12-12; FR2002-0015738 Applic. Date: 2002-12-12; US2003-0735156 Applic. Date: 2003-12-12

Inventor: LION BERTRAND (FR)

A1 Published: 2009-01-01

Title: Non-Irritant Rapid-Action Dipilatory Composition

Applicant: PRODUCCIONES INFOVISION (MX)

Application No.: US2005-0718306 Applic. Date: 2005-10-24

Abstract: The invention relates to a rapid-action depilatory composition, comprising at least one bisulphic and/or sulphite compound and an organic reducing agent in a cosmetically acceptable medium.

Priority: FR2004-0011594 Applic. Date: 2004-10-29; WO2005-FR02642 Applic. Date: 2005-10-24

Inventor: FLORK MICHEL (FR)

A1 Published: 2009-01-01

Title: Methods for treating pustular conditions of the skin

Application No.: US2008-0215092 Applic. Date: 2008-06-25

Abstract: The invention is directed to methods for treating pustular conditions of the skin, for example, acne. Such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as ECS cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells), conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), cell lysates derived therefrom, and cell products derived therefrom, each alone or in combination.

Priority: US2008-0215092 Applic. Date: 2008-06-25; US2007-0937231P Applic. Date: 2007-06-26

Inventor: PALLADINO LINDA O (US); MARSHALL VIVIENNE S (US); CLARKE DIANA L (US); SMITH CHARLOTTE A (US); ROBSON MARTIN C (US)

A1 Published: 2009-01-01

Title: Expansion of Stem/Progenitor Cells by Inhibition of Enzymatic Reactions Catalyzed by the Sir2 Family of Enzymes

Application No.: US2005-0631992 Applic. Date: 2005-07-14

Abstract: Provided are ex vivo and in vivo methods of expanding renewable stem cells using agents capable of down-regulating Sir2 protein activity and/or expression, expanded populations of renewable stem cells, and uses thereof.

Priority: US2005-0631992 Applic. Date: 2005-07-14; US2004-0587496P Applic. Date: 2004-07-14; WO2005-IL00753 Applic. Date: 2005-07-14

Inventor: PELED TONY (IL)

A1 Published: 2009-01-01

Title: ANTIBODIES THAT BIND BOTH IL-17A AND IL-17F AND METHODS OF USING THE SAME

Application No.: US2007-0741189 Applic. Date: 2007-04-27

Abstract: The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A and IL-17F. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. The present invention includes antibodies that bind both IL-17A and IL-17F, hybridomas that produce the antibodies, an methods of using the same in inflammation.

Priority: US2007-0741189 Applic. Date: 2007-04-27; US2007-0684907 Applic. Date: 2007-03-12; US2006-0781121P Applic. Date: 2006-03-10; US2006-0828271P Applic. Date: 2006-10-05; US2006-0862501P Applic. Date: 2006-10-23

Inventor: JASPERS STEPHEN R (US); PRESNELL SCOTT R (US); HUBER MONICA (US)

A1 Published: 2009-01-01

Title: 4'-O- substituted isoindoline derivatives and compositions comprising and methods of using the same

Application No.: US2008-0077715 Applic. Date: 2008-03-19

Abstract: Provided are 4'-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.

Priority: US2008-0077715 Applic. Date: 2008-03-19; US2007-0919323P Applic. Date: 2007-03-20

Inventor: RUCHELMAN ALEXANDER L (US); MULLER GEORGE W (US); MAN HON-WAH (US)

A1 Published: 2009-01-01

Title: PESTICIDAL EAR TAG

Application No.: US2008-0042711 Applic. Date: 2008-03-05

Abstract: Pesticidal compositions and articles providing topical application of a mixture of (1) a macrolide of the avermectin/milbemycin class, such as, but not limited to ivermectin, abamectin, or milbemectin, and (2) a synergist of the aryl aliphatic ether-class, such as, but not limited to piperonyl butoxide, present in (3) a weight ratio of synergist:macrolide that is great than 1:1. The compositions and articles demonstrate efficacy, even in point-of-contact applications, against various pests of domestic animals, such as, but not limited to arthropod ectoparasites including horn flies and buffalo flies.; Methods are provided in which compositions can be employed as pour-ons, spot-ons, dusts, or sprays for direct topical application to the domestic animal; or in which articles comprising a polymer resin base, such as an ear tag, from which the active ingredients of the composition can be released, are affixed to the animal to provide long-term delivery.

Priority: US2008-0042711 Applic. Date: 2008-03-05; WO2007-US21243 Applic. Date: 2007-10-03; US2007-0947265P Applic. Date: 2007-06-29

Inventor: KELLERBY JOE D (US)

A1 Published: 2009-01-01

Title: Enzymatically Crosslinked Protein Nanoparticles

Applicant: FUJIFILM CORP (JP)

Application No.: US2007-0160175 Applic. Date: 2007-01-30

Abstract: It is an object of the present invention to provide highly safe nanoparticles made from highly biocompatible materials without the use of a surfactant or synthetic polymer. The present invention provides a protein nanoparticle which is obtained by enzymatic crosslinking during and/or after the formation of protein nanoparticle.

Priority: JP2006-0020020 Applic. Date: 2006-01-30; JP2006-0326640 Applic. Date: 2006-12-04; WO2007-JP51856 Applic. Date: 2007-01-30

Inventor: AIMI MAKIKO (JP); NEMORI RYOICHI (JP); MIYASHITA YOUSUKE (JP); YOKOYAMA HIROSHI (JP)

A1 Published: 2009-01-01

Title: KIT FOR CARING FOR THE SKIN INTENDED TO SOFTEN CUTANEOUS SIGNS OF AGEING

Applicant: OREAL (FR)

Application No.: US2008-0208484 Applic. Date: 2008-09-11

Abstract: A kit for skin care intended to soften cutaneous signs of ageing, contains in separate packagings, a microdermabrasion composition, a peeling composition, a soothing composition and an anti-ageing composition.

Priority: US2008-0208484 Applic. Date: 2008-09-11; FR2004-0053043 Applic. Date: 2004-12-17; US2005-0287420 Applic. Date: 2005-11-28; US2005-0663202P Applic. Date: 2005-03-21

Inventor: MARION CATHERINE (FR)

A1 Published: 2009-01-01

Title: PERSONAL LUBRICANT FORMULATIONS COMPRISING COLLOIDAL METALS AND METHODS OF USE

Applicant: PHARMWEST INC (US)

Application No.: US2007-0936696 Applic. Date: 2007-11-07

Abstract: Lubricant compositions and methods are disclosed for aiding and enhancing massage or sexual activity, treating and preventing sexually transmitted diseases, and preventing pregnancy by administering a colloidal metal containing composition. Colloidal metal containing compositions that include metal flakes, sperm-function inhibitors, antimicrobial agents, analgesics, plant extracts, anti-oxidizing agents, and anti-inflammatory agents are also provided and may advantageously be used to in the methods of the invention.

Priority: US2007-0936696 Applic. Date: 2007-11-07; US2006-0857270P Applic. Date: 2006-11-07

Inventor: MARGULIES JOEL (US); JACOBS TERRY (US)

A1 Published: 2009-01-01

Title: Aloe Vera Extract, Method of Producing Aloe Vera Extract, and Hyperglycemia Improving Agent

Applicant: MORINAGA MILK INDUSTRY CO LTD (JP)

Application No.: US2006-0815428 Applic. Date: 2006-11-20

Abstract: The present invention provides: an Aloe vera extract that can be safely ingested, can be used as a material of food for preventing lifestyle diseases, contains an extremely low level of an anthraquinone (anthraquinone-based compound), and can be added to foods; and a method of producing the Aloe vera extract. A supercritical fluid extraction method can produce an Aloe vera extract containing a mixture that consists of a cyclolanostane compound and a lophenol compound in an amount of 1.0% by mass or more and having the following properties (1) and/or (2): (1) the mass mixing ratio of the cyclolanostane compound and lophenol compound is as follows: cyclolanostane compound: lophenol compound=6.3:2.7 to 5.1:4.9; and/or (2) the content of an anthraquinone-based compound is 0.001% by mass or less.

Priority: JP2005-0340245 Applic. Date: 2005-11-25; WO2006-JP323095 Applic. Date: 2006-11-20

Inventor: TANAKA MIYUKI (JP); YAMADA MUNEO (JP)

A1 Published: 2009-01-01

Title: AChE antisense oligonucleotide as an anti-inflammatory agent

Applicant: MOR RESEARCH APPLIC LTD

Application No.: US2007-0788321 Applic. Date: 2007-04-18

Abstract: Disclosed is a novel use for AChE antisense oligonucleotides as anti-inflammatory agents, wherein said oligonucleotides are preferably as denoted by SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:7. Methods of treatment of inflammatory conditions, as well as fever, and particularly inflammation-associated neuropathies such as Guillain-Barré Syndrome, are described.

Priority: US2007-0788321 Applic. Date: 2007-04-18; IL2003-0158600 Applic. Date: 2003-10-26; US2005-0187719 Applic. Date: 2005-07-21; WO2004-IL00978 Applic. Date: 2004-10-26

Inventor: SOREQ HERMONA (IL); DORI AMIR (IL); WIRGUIN ITZHAK (IL); IFERGANE GAL (IL); YIRMIYA RAZ (IL)

A1 Published: 2009-01-01

Title: Ethanol or 1,2-Ethanediol Cyclohexyl Antibiotic Derivatives

Applicant: ACTELION PHARMACEUTICALS LTD (CH)

Application No.: US2007-0279329 Applic. Date: 2007-02-14

Abstract: The invention relates to antibiotic ethanol or 1,2-ethanediol cyclohexyl derivatives of formula (I) wherein R1 represents (C1-C4)alkoxy; one or two of U, V, W and X represents) N and the remaining represent each independently CH or, in the case of V or X, may also represent CRa; Ra represents halogen; R2 represents H or OH; A represents CH2, CO, CH2CH-CH or COCH-CH; D represents a phenyl group optionally substituted one or two times by halogen atoms, or D represents a group of the formula (II) in which Q is oxygen or sulphur; and to salts of these derivatives of formula (I).

Priority: WO2006-IB50505 Applic. Date: 2006-02-15; WO2007-IB50482 Applic. Date: 2007-02-14

Inventor: HUBSCHWERLEN CHRISTIAN (FR); SURIVET JEAN-PHILIPPE (FR); ZUMBRUNN ACKLIN CORNELIA (CH)

A1 Published: 2009-01-01

Title: Use of Isothiocyanates Compounds in Treating Prostatic Diseases and Skin Cancer

Applicant: WUXI JC PHARMACEUTICAL TECHNOL

Application No.: US2006-0093829 Applic. Date: 2006-11-14

Abstract: A method for preventing and treating prostatic diseases and skin cancer using naturally or artificially synthesized isothiocyanates compounds or the derivatives or metabolites thereof.

Priority: CN2005-1095737 Applic. Date: 2005-11-15; CN2006-1038112 Applic. Date: 2006-01-27; WO2006-CN03062 Applic. Date: 2006-11-14

Inventor: CHENG JINGCAI (CN); CHIAO JENWEI (CN); JIN HAIYA (CN); ZHONG CHENGJUAN (CN)

A1 Published: 2009-01-01

Title: Diphenyl Urea Derivatives

Applicant: ARIPIDA AG (CH)

Application No.: US2006-0096831 Applic. Date: 2006-12-08

Abstract: The invention relates to novel specifically trifluoromethyl and halogen substituted 1,3-diphenyl ureas and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects like the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as anti-infectives.

Priority: WO2005-EP13345 Applic. Date: 2005-12-13; WO2006-EP11795 Applic. Date: 2006-12-08

Inventor: LOEWE RALF (CH); LOCIURO SERGIO (CH); HAWSER STEPHEN (FR); SCHMITT LAURENT (FR)

A1 Published: 2009-01-01

Title: Skin-contacting-adhesive free dressing

Application No.: US2008-0231104 Applic. Date: 2008-08-29

Abstract: A dressing having a flexible sleeve shaped to accommodate a substantially cylindrical body portion, the sleeve having a lining which is substantially non-adherent to the body part being bandaged and having a peripheral securement means which attaches two peripheral portions to each other without those portions being circumferentially adhered to the sleeve portion.

Priority: US2008-0231104 Applic. Date: 2008-08-29; US2006-0434689 Applic. Date: 2006-05-16

Inventor: JENNLNGS-SPRING BARBARA (US)

A1 Published: 2009-01-08

Title: FOAMING OIL COMPOSITIONS

Application No.: US2008-0147074 Applic. Date: 2008-06-26

Abstract: A personal care composition comprising an oil and a siloxane resin foam stabilizer, said composition being substantially free of surfactants and propellants, is provided. The composition is capable of foaming, and is advantageously clear and non-greasy.

Priority: EP2007-0012898 Applic. Date: 2007-07-02

Inventor: ARIF AMBAREEN (CH); MUTTI BRUNA (DE); ROUET SOPHIE (FR)

A1 Published: 2009-01-08

Title: Cosmetic Compositions

Applicant: BOOTS CO PLC (GB)

Application No.: US2005-0577451 Applic. Date: 2005-10-13

Abstract: There is disclosed a skincare composition suitable for topical application to the skin. The composition comprises two or more active ingredients selected from the group consisting of a) dipalmitoyl hydroxyproline, salts and esters thereof; b) carnitine; and c) an extract of Haematococcus pluvialis. Compositions prepared in accordance with the invention are useful for improving the appearance of the skin.

Priority: US2005-0577451 Applic. Date: 2005-10-13; GB2004-0023164 Applic. Date: 2004-10-19; US2005-0712396P Applic. Date: 2005-08-31; WO2005-GB03946 Applic. Date: 2005-10-13

Inventor: BARTON STEPHEN PETER (GB); LONG STEWART PAUL (GB); HAMILTON LLOYD GEORGE (GB)

A1 Published: 2009-01-08

Title: Low residue deodorant or antiperspirant stick based on an ethanol-containing oil-in-water dispersion/emulsion

Application No.: US2007-0960348 Applic. Date: 2007-12-19

Abstract: Deodorant or antiperspirant sticks based on an ethanol-containing oil-in-water dispersion/emulsion for application on the skin.

Priority: US2007-0960348 Applic. Date: 2007-12-19; DE2005-10029777 Applic. Date: 2005-06-24; DE2006-10021780 Applic. Date: 2006-05-09; WO2006-EP05787 Applic. Date: 2006-06-16; US2006-0788023P Applic. Date: 2006-03-30; US2006-0799160P Applic. Date: 2006-05-10

Inventor: BANOWSKI BERNHARD (DE); WADLE ARMIN (DE); CLAAS MARCUS (DE)

A1 Published: 2008-01-17
Patent No.: US2009010869A9 Issued: 2009-01-08

Title: Compositions for Topical Enzymatic Debridement

Applicant: COLLEGIUM PHARMACEUTICAL INC

Application No.: US2007-0843158 Applic. Date: 2007-08-22

Abstract: Formulations are described for the treatment by enzymatic debridement of wounds and ulcers. The formulations have a clear, transparent composition that allows for easy visualization of the wound, and are non-staining for easy clean up. These formulations can also exhibit increased enzymatic debridement activity, improved post-treatment lubricity and coating occlusivity, and stability. The formulations, optionally containing non-animal source biologics, may be in the form of lotions, aerosols to provide a spray, or a foam. A non-reactive substrate may be used as a composition carrier. A non-aqueous lotion formulation having improved enzymatic activity is provided. The non-aqueous lotion viscosity is adjusted to achieve high enzymatic activity while maintaining the application benefits of high viscosity non-aqueous lotions. The lotion formulation may be delivered in a patch.

Priority: US2007-0843158 Applic. Date: 2007-08-22; US2005-0147567 Applic. Date: 2005-06-08; US2005-0642835P Applic. Date: 2005-01-11; US2004-0608991P Applic. Date: 2004-09-10; US2004-0604900P Applic. Date: 2004-08-27; US2004-0580085P Applic. Date: 2004-06-16

Inventor: TRUMBORE MARK W (US); RARIY ROMAN V (US); HIRSH MARK (US); HIRSH JANE C (US); SAUNDERS JULIE A (US)

A1 Published: 2009-01-08

Title: Methods of Cell Therapy, Neurogenesis and Oligodendrogenesis

Applicant: YEDA RES & DEV (IL)

Application No.: US2005-0720417 Applic. Date: 2005-11-29

Abstract: A method is provided for inducing and enhancing neurogenesis and/or oligodendrogenesis from endogenous as well as from exogenously administered stem cells, which comprises administering to an individual in need a neuroprotective agent such as a nervous system (NS)-specific antigen, a peptide derived therefrom, T cells activated therewith, poly-YE, microglia activated by IFN-gamma and/or IL-4 and combinations thereof. The method includes stem cell therapy in combination with the neuroprotective agent.

Priority: US2005-0720417 Applic. Date: 2005-11-29; US2004-0631163P Applic. Date: 2004-11-29; WO2005-IL01270 Applic. Date: 2005-11-29

Inventor: EISENBACH-SCHWARTZ MICHAL (IL); BUTOVSKY OLEG (IL); ZIV YANIV (IL); KIFNIS JONATHAN (IL); RON NOGA (IL)

A1 Published: 2009-01-08

Title: COMPOSITIONS AND METHODS FOR DERMATOLOGICAL WOUND HEALING

Applicant: MEDIWOUND LTD (IL)

Application No.: US2005-0571880 Applic. Date: 2005-07-13

Abstract: The invention relates to compositions for debriding damaged skin comprising at least one enzymatic debriding agent and at least one antiseptic compound comprising heavy metal ions. The present invention further relates to kit and methods for topical debridement of damaged skin, particularly of burned skin.

Priority: US2005-0571880 Applic. Date: 2005-07-13; US2004-0587057P Applic. Date: 2004-07-13; WO2005-IL00744 Applic. Date: 2005-07-13

Inventor: TOREN AMIR (IL); ROSENBERG LIOR (IL); GORECKI MARIAN (IL)

A1 Published: 2009-01-08

Title: Novel Stromal Cell-Derived Factor-1 Polypeptides, Polynucleotides, Modulators Thereof and Methods of Use

Applicant: FIVE PRIME THERAPEUTICS INC (US)

Application No.: US2005-0587651 Applic. Date: 2005-04-29

Abstract: Disclosed herein is a newly identified SDF-1 splice variant molecule, its polypeptide sequence, and the polynucleotides encoding the polypeptide sequence, and active fragments thereof. Also provided is a procedure for producing such polypeptides by recombinant techniques employing, for example, vectors and host cells. Also disclosed are methods for utilizing such polypeptides and modulators thereof for the treatment of diseases, including cancer, immune diseases, infectious diseases, and ischemic diseases.

Priority: US2005-0587651 Applic. Date: 2005-04-29; US2004-0567311P Applic. Date: 2004-04-30; WO2005-US14963 Applic. Date: 2005-04-29

Inventor: CHU KETING (US); WILLIAMS LEWIS T (US); WONG JUSTIN G P (US); HESTIR KEVIN (US); COLLINS AMY L TSUI (US); LEE ERNESTINE (US)

A1 Published: 2009-01-08

Title: Spot-on formulation useful for cosmetology and dermatology

Application No.: US2005-0596334 Applic. Date: 2005-05-12

Abstract: The invention relates to a novel formulation of use in cosmetology and in dermatology which uses the storage capacity of the sebaceous glands. The formulation is of the spot-on type and comprises a lipophilic active principle chosen from vitamin A, vitamin E a lipophilic agent for combating free radicals, ceramides or sphingoid bases and steroid hormones, in combination with one or more unsaturated C4-C26 fatty acids and a liquid vehicle, having sebaceous tropism. Application to the localized topical administration of lipophilic active principles.

Priority: FR2004-0005136 Applic. Date: 2004-05-12; WO2005-FR01188 Applic. Date: 2005-05-12

Inventor: ALLART JEAN-CLAUDE (FR); LEFEVRE JEAN-MARIE (FR); PEYROT JACQUES (FR); MARTY JEAN-PAUL (FR)

A1 Published: 2009-01-08

Title: Cosmetic or dermopharmaceutical compositions containing kombucha

Applicant: SEDERMA (FR)

Application No.: US2008-0231114 Applic. Date: 2008-08-29

Abstract: Cosmetic or dermopharmaceutical compositions which contain kombucha are disclosed. The present invention further relates to the use of kombucha and cosmetic or dermopharmaceutical compositions containing the same, alone or in combination, for the care of the skin, mucosae and skin appendages, and in particular for preventing the signs of endogenous and/or exogenous ageing.

Priority: US2008-0231114 Applic. Date: 2008-08-29; FR2002-0009710 Applic. Date: 2002-07-30; US2005-0523333 Applic. Date: 2005-08-29; WO2003-FR02368 Applic. Date: 2003-07-25

Inventor: LINTNER KARL (FR)

A1 Published: 2009-01-08

Title: Green tea jewelry

Applicant: SOUTHERLEE INC (US)

Application No.: US2008-0231096 Applic. Date: 2008-08-28

Abstract: A method for making green tea jewelry is provided. The jewelry may be worn as a transdermal source of green tea components used as an alternative to or in addition to ingestion of green tea liquid or solids. Also provided is a kit for providing green tea jewelry in a substantially water resistant and air-tight package. The kit may comprise additional articles such as informational inserts and scents.

Priority: US2008-0231096 Applic. Date: 2008-08-28; US2006-0379556 Applic. Date: 2006-04-20

Inventor: JENSEN DAVID MATTHEW (US)

A1 Published: 2009-01-08

Title: Drug-delivery patch comprising a dissolvable layer and uses thereof

Application No.: US2008-0217393 Applic. Date: 2008-07-03

Abstract: The present invention provides a drug-delivery patch having at least one dissolvable layer comprising an active material and an adhesive backing or cover. The present invention also provides a method of transdermally vaccinating an animal by ablating an area of the stratum corneum of the animal and applying the patch described herein to the area.

Priority: US2008-0217393 Applic. Date: 2008-07-03; US2007-0947724P Applic. Date: 2007-07-03

Inventor: MARCHITTO KEVIN S (US); FLOCK STEPHEN T (US)

A1 Published: 2009-01-08

Title: Use of deuterium oxide for treatment of virus-based diseases of the skin

Application No.: US2008-0168583 Applic. Date: 2008-07-07

Abstract: The present invention relates to the use of deuterium dioxide (D2O) for prevention and/or treatment of virus-based diseases of the skin, in particular herpes virus-based and verrucal virus-based diseases of the skin.

Priority: DE2007-10031397 Applic. Date: 2007-07-05

Inventor: BAYERL THOMAS M (GB)

A1 Published: 2009-01-08

Title: TRANSCORNEAL SYSTEM FOR DELIVERY OF A PHARMACEUTICAL AGENT

Application No.: US2006-0063876 Applic. Date: 2006-08-23

Abstract: The invention relates to a transcorneal system for delivery of a pharmaceutical agent, made from a matrix material forming a baseplate (1), said baseplate (1) being connected to a number of projections (4) for penetration of the Stratum corneum of the skin, said projections (4) being made from the matrix material and comprising the agent.

Priority: DE2005-10040251 Applic. Date: 2005-08-24; WO2006-EP65585 Applic. Date: 2006-08-23

Inventor: EGEN MARC (DE); PICCINI MARIA (DE); GESER JOHANNES (DE); FEIERTAG CHRISTIAN (DE)

A1 Published: 2009-01-08

Title: Personal care composition

Application No.: US2007-0825103 Applic. Date: 2007-07-03

Abstract: Stable personal care composition comprising from about 0.1% to about 15% of a non-emulsifying crosslinked siloxane elastomer; from about 0.1% to about 15% of an emulsifying crosslinked siloxane elastomer; from about 1% to about 40% of an elastomer solvent; less than 0.1% of a solidifying agent; an aqueous phase comprising from about 0.0001% to about 10%, by weight of the composition, of a hydrophilic colorant; whereupon application of shear force to the composition a visibly enhanced aqueous phase is visibly separated from the non-aqueous phase.

Priority: US2007-0825103 Applic. Date: 2007-07-03

Inventor: ZUKOWSKI JOSEPH MICHAEL (US); GRIFFITHS-BROPHY SUSAN ADAIR (US); VATTER MICHAEL LEE (US); CONSTANTINIDES IOANNIS CONSTANTINE (US); ZHU CHU (US)

A1 Published: 2009-01-08

Title: COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING PEPTIDES, USES AND TREATMENT PROCESSES

Applicant: SOC EXTRACTION PRINCIPES ACTIF (FR)

Application No.: US2008-0134795 Applic. Date: 2008-06-06

Abstract: The present invention has as an aim a cosmetic and/or dermatological and/or pharmaceutical composition comprising, as an active ingredient, at least a peptide of sequence X1-Y-Phe-Thr-X2-Ala-Thr-Z-Ile-X3-Leu-X4-Phe-Leu-X5 (SEQ ID NO: 1); wherein: X1, X2, X3, X4, X5=Arg, Lys, His; Y=Asp, Glu; Z=Asn, Gln, or one of its fragment containing from 4 to 7 amino acids, and the motif Phe-Leu. The invention also relates to a method for preventing or treating skin against the manifestations of cutaneous aging.

Priority: US2008-0134795 Applic. Date: 2008-06-06; FR2002-0003306 Applic. Date: 2002-03-18; US2004-0508245 Applic. Date: 2004-09-20; WO2003-FR00817 Applic. Date: 2003-03-14

Inventor: DAL FARRA CLAUDE (FR); DOMLOGE NOUHA (FR)

A1 Published: 2009-01-08

Title: DIPEPTIDYL PEPTIDASE INHIBITORS

Application No.: US2007-0929593 Applic. Date: 2007-10-30

Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C-NR9; and each L, X, R1, R2, and R3 are as defined herein.

Priority: US2007-0929593 Applic. Date: 2007-10-30; US2005-0080992 Applic. Date: 2005-03-15; US2004-0553571P Applic. Date: 2004-03-15; US2004-0629524P Applic. Date: 2004-11-18

Inventor: FENG JUN (US); GWALTNEY STEPHEN L (US); STAFFORD JEFFREY A (US); ZHANG ZHIYUAN (US); ELDER BRUCE J (US); ISBESTER PAUL K (US); PALMER GRANT J (US); SALSBURY JONATHON S (US); ULYSSE LUCKNER G (US)

A1 Published: 2009-01-08

Title: 4-SUBSTITUTED-1H-ISOTHIAZOLO[5,4-B][1,4]OXAZINO[2,3,4-IJ]QUINOLINE-7,8(2H,9H)-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS

Applicant: ACHILLION PHARMACEUTICALS INC (US)

Application No.: US2008-0108106 Applic. Date: 2008-04-23

Abstract: The present invention provides compounds of the formula that possess antimicrobial activity. Certain compounds provided herein possess potent antibacterial, antiprotozoal, or antifungal activity. Particular compounds provided herein are also potent and/or selective inhibitors of microbial DNA synthesis and reproduction. The invention provides anti-microbial compositions, including pharmaceutical compositions, containing a compound of the invention and one or more or more carriers. The invention provides pharmaceutical compositions containing a 4-substituted-1H-isothiazolo[5,4-b][1,4]oxazino[2,3,4-ij]quinoline-7,8(2H,9H)-dione or related compound as the only active agent or in combination with one or more other active agents.; The invention provides methods for treating or preventing microbial infections, preferably animals, by administering an effective amount of a 4-substituted-1H-isothiazolo[5,4-b][1,4]oxazino[2,3,4-ij]quinoline-7,8(2H,9H)-dione or related compound to an organism suffering from or susceptible to microbial infection. The invention also provides methods of inhibiting microbial growth and survival by applying an effective amount of a 4-substituted-1H-isothiazolo[5,4-b][1,4]oxazino[2,3,4-ij]quinoline-7,8(2H,9H)-dione or related compound.

Priority: US2008-0108106 Applic. Date: 2008-04-23; US2007-0913404P Applic. Date: 2007-04-23

Inventor: BRADBURY BARTON JAMES (US); DESHPANDE MILIND (US); HASHIMOTO AKIHIRO (US); KIM HA YOUNG (US); LUCIEN EDLAINE (US); PAIS GODWIN (US); PUCCI MICHAEL JOHN (US); WANG QIUPING (US); WILES JASON ALLAN (US)

A1 Published: 2009-01-08

Title: Polycyclic 1,2,3,4-Tetrahydro-Isoquinoline Derivatives and Compositions Comprising Them As Ppar Modulators

Applicant: IRM LLC (BM)

Application No.: US2007-0160305 Applic. Date: 2007-01-25

Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.

Priority: US2007-0160305 Applic. Date: 2007-01-25; US2006-0763623P Applic. Date: 2006-01-30; WO2007-US02115 Applic. Date: 2007-01-25

Inventor: EPPLE ROBERT (US); COW CHRISTOPHER (US)

A1 Published: 2009-01-08

Title: Composition Of Skin External Application For Anti-Aging

Application No.: US2006-0064887 Applic. Date: 2006-09-08

Abstract: The present invention relates to an anti-aging composition for external use on skin, and more particularly, to an anti-aging composition for external use on skin comprising at least one of catechins and flavonols as an active ingredient to inhibit decomposition and promote generation or protection at the dermis-epidermis junction.

Priority: KR2005-0083665 Applic. Date: 2005-09-08; KR2005-0083667 Applic. Date: 2005-09-08; KR2006-0021797 Applic. Date: 2006-03-08; WO2006-KR03571 Applic. Date: 2006-09-08

Inventor: KIM JEONG KI (KR); SHIN HYUN JUNG (KR); KIM SU NAM (KR); LEE BYEONG GON (KR); CHANG IH SEOP (KR)

A1 Published: 2009-01-08

Title: HIGH PURITY BASES OF 3,3-DIPHENYLPROPYLAMINO MONOESTERS

Application No.: US2008-0141489 Applic. Date: 2008-06-18

Abstract: The invention relates to a compound of general formula (I) wherein A represents deuterium or hydrogen, R represents a group selected from C1-6 alkyl, C3-10 cycloalkyl or phenyl, which can be substituted by C1-3 alkoxy, fluorine, chlorine, bromine, iodine, nitro, amino, hydroxyl, oxo, mercapto or deuterium. The C atom marked with a * (star) can be present in an (R) configuration, in an (S)-configuration or a mixture thereof. The invention is characterised in that the above-mentioned compounds are free bases with a degree of purity of more than 97 wt %. The invention also relates to a method for the production of highly pure compounds of general formula (I) and to the use thereof in the production of medicaments.

Priority: US2008-0141489 Applic. Date: 2008-06-18; DE2003-1015917 Applic. Date: 2003-04-08; US2005-0532836 Applic. Date: 2005-04-26; WO2004-EP03567 Applic. Date: 2004-04-03

Inventor: BREITENBACH ARMIN (DE); MEESE CLAUS (DE); WOLFF HANS-MICHAEL (DE); DREWS ROLAND (DE)

A1 Published: 2009-01-08

Title: Compositions Having a High Antiviral and Antibacterial Efficacy

Applicant: DIAL CORP (US)

Application No.: US2008-0188714 Applic. Date: 2008-08-08

Abstract: Antimicrobial compositions having a rapid antiviral and antibacterial effectiveness, and a persistent antiviral effectiveness, are disclosed. The antimicrobial compositions contain (a) a disinfecting alcohol, (b) an organic acid, (c) a buffering agent, and (d) water, wherein the composition has a pH of about 5 or less.

Priority: US2008-0188714 Applic. Date: 2008-08-08; US2008-0791257 Applic. Date: 2008-03-04; WO2005-US43910 Applic. Date: 2005-12-05; US2004-0634464P Applic. Date: 2004-12-09

Inventor: SEITZ JR EARL P (US); THEILER RICHARD F (US); FOX PRISCILLA S (US)

A1 Published: 2009-01-08

Title: REVERSIBLY GELLING POLYURETHANE COMPOSITION FOR SURGICAL REPAIR AND AUGMENTATION

Applicant: PROMETHEAN SURGICAL DEVICES IN (US)

Application No.: US2007-0162039 Applic. Date: 2007-01-24

Abstract: A new reversibly gelling polyurethane (RGP) polymer composition is described, as well as novel processes for its preparation, and its medical uses for filling spaces in tissue, or bulking tissue, or for restoring organ function. The novel RGP polymer forms a gel on standing, liquefies during shear and reversibly reforms a macroscopic gel on standing after being sheared. Methods of use include delivering the improved gel to a site on the body to fill voids or to augment local tissue bulk.

Priority: US2007-0162039 Applic. Date: 2007-01-24; US2006-0762302P Applic. Date: 2006-01-26; WO2007-US01830 Applic. Date: 2007-01-24

Inventor: MILBOCKER MICHAEL T (US); WILSON JEFFREY A (US)

A1 Published: 2009-01-08

Title: INTRADERMAL DELIVERY OF BIOLOGICAL AGENTS

Applicant: NANOPASS TECHNOLOGIES LTD (IL)

Application No.: US2007-0946889 Applic. Date: 2007-11-29

Abstract: The present invention relates to methods for intradermally delivering one or more biologically active agents such as vaccines and therapeutic agents into the dermis layer of the skin of a subject to obtain systemic delivery or an immune response using a microneedle drug delivery device containing the agent to be delivered. The methods employ a microneedle device with a row of hollow microneedles. The microneedles penetrate the skin of the subject and assume an anchored state in which the microneedles are anchored in the skin and project laterally from the device. A pivotal motion is then performed with the device so that the skin in which the microneedles are engaged is lifted above the initial plane of the surface of the skin while the biologically active agent is delivered.; The methods of the invention elicit increased humoral and/or cellular response as compared to conventional vaccine delivery routes, facilitating dose sparing.

Priority: GB2006-0020617 Applic. Date: 2006-10-17; WO2007-IL01244 Applic. Date: 2007-10-17

Inventor: YESHURUN YEHOSHUA (IL); LEVIN YOTAM (IL); ALMAGOR YOTAM (IL); LAVI GILAD (IL); HEFETZ MEIR (IL); SEFI YOEL (IL); CATCHPOLE RICHARD IAN (GB)

A1 Published: 2009-01-08

Title: Transgenic Animals for Assessing Drug Metabolism and Toxicity in Man

Applicant: IMP CANCER RES TECH (GB)

Application No.: US2008-0597600 Applic. Date: 2008-03-24

Abstract: A method of introducing at least one human cytochrome P450 into a non-human animal c ell in which corresponding endogenous P450 enzyme activities have been disabled, thus the method provides a way of using a non-human animal cell to make predictions regarding P450-mediated metabolism in a human. The present invention also provides transgenic non-human animals produced by the method of the invention and uses therefor, especially in assessing xenobiotic/drug metabolism and toxicity.

Priority: GB2004-0002318 Applic. Date: 2004-02-03; WO2005-GB00382 Applic. Date: 2005-02-03

Inventor: WOLF CHARLES ROLAND (GB); HENDERSON COLIN J (GB)

A1 Published: 2009-01-15

Title: CONTINUOUS SPRAY SCALP THERAPY AND DISPENSING SYSTEMS FOR SAME

Application No.: US2008-0193153 Applic. Date: 2008-08-18

Abstract: A spray delivery system in combination with a scalp medication is provided which includes a portable container having a gas imperious container wall, a pressure source disposed within the container, and a selectively operable valve assembly affixed to the container. The scalp medication is in liquid form and is disposed within the container. The scalp medication comprises a hair growth stimulation or hair growth maintenance active ingredient in an amount sufficient to stimulate or maintain hair growth disposed within a pharmacologically acceptable carrier solution. The valve assembly of the system produces a 1 mL spray of said scalp medication within about 5 seconds following a single operation of said valve assembly. A method of treating alopecia using a continuous spray employing such a system is also provided. Both bag-on-valve (bag-in-can) and metered dose packages are disclosed.

Priority: US2008-0193153 Applic. Date: 2008-08-18; WO2008-US54754 Applic. Date: 2008-02-22; US2007-0677777 Applic. Date: 2007-02-22

Inventor: CRONK PETER J (US)

A1 Published: 2009-01-15

Title: Aqueous fluid photoprotective compositions comprising tertiary-amide-terminated polyamide polymers

Applicant: OREAL (FR)

Application No.: US2008-0216890 Applic. Date: 2008-07-11

Abstract: Topically applicable, fluid anti-sun/sunscreen compositions useful for protecting the skin and/or the hair against the damaging effects of ultraviolet radiation, contain: (a) at least one photoprotective system for screening out UV radiation; and (b) at least one tertiary-amide-terminated polyamide (ATPA) polymer, formulated into a topically applicable, cosmetically acceptable aqueous support therefor; the subject anti-sun/sunscreen compositions are especially provided as sprays, notably for the purpose of increasing the sun protection factor (SPF) and/or of reducing or even eliminating the fluffing effect thereof.

Priority: US2008-0216890 Applic. Date: 2008-07-11; FR2007-0056456 Applic. Date: 2007-07-12; US2007-0959923P Applic. Date: 2007-07-18

Inventor: GAUDRY ANNE-LAURE (FR); JOSSO MARTIN (FR)

A1 Published: 2009-01-15

Title: Oral cavity care curative and prophylactic composition

Application No.: US2008-0094605 Applic. Date: 2008-09-19

Abstract: The invention relates to stomatology and perfume industry in particular to therapeutic formulation for oral cavity care. The invention refers to oral hygiene means and can be applied for preparation of medical and prophylactic tooth-pastes, gels, liquids for oral care as well as other compositions like chewing gums, jellies, etc. Formulation containing orally applicable active and inert components involves bromelain in amount of 0.01/1 wt %, xylitol 1.5/20 wt %. At best bromelain content is 0.1-0.8 wt %, xylitol content-2.2-18 wt %. For attaining remineralizing effect formulation contains anti-carious mineral additive 0.05-3.0 wt % of the list of active components. At best anti-carious mineral additive content is 0.2-2.5 wt %. There are used calcium glycerophosphate and inorganic or organic magnesium salt as anti-carious mineral additive.; It is acceptable to use sodium monofluorphosphate, potassium monofluorphosphate, calcium monofluorphosphate or magnesium monofluorphosphate in amount of 0.5-1.5 wt % as anti-carious mineral additive Optimum concentration is 0.8-1.1 wt %.

Priority: WO2005-RU00601 Applic. Date: 2005-11-25

Inventor: MANASHEROV TAMAZI OMAROVICH (RU); MATELO SVETLANA KONSTANTINOVNA (RU); GROSSER ALEXANDR VLADIMIROVICH (RU)

A1 Published: 2009-01-15

Title: Application of dehydroascorbic acid or derivatives/isomers thereof for artificially coloring the skin

Applicant: OREAL (FR)

Application No.: US2008-0216693 Applic. Date: 2008-07-09

Abstract: Dehydroascorbic acid and polymeric/monomeric derivatives and isomers thereof are useful for artificially coloring the skin and more particularly as a skin self-tanning agent; the dehydroascorbic acid may be formed "in situ" from ascorbic acid or a derivative or salt thereof via chemical oxidation and/or via enzymatic oxidation, and a two-component agent thereof includes a) a first component (B) containing, in a physiologically acceptable medium, at least ascorbic acid or a derivative or salt thereof; b) a second component (C) containing, in a physiologically acceptable medium, at least one chemical oxidizing agent and/or one enzymatic oxidizing agent; components (B) and (C) being stored separately.

Priority: US2008-0216693 Applic. Date: 2008-07-09; FR2007-0056353 Applic. Date: 2007-07-09; US2007-0929965P Applic. Date: 2007-07-19

Inventor: PRUCHE FRANCIS (FR); CHOISY PATRICK (FR)

A1 Published: 2009-01-15

Title: PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISORDERS

Application No.: US2008-0202784 Applic. Date: 2008-09-02

Abstract: The present invention relates to novel pharmaceutical compositions comprising at least one EGFR kinase inhibitor and at least one additional active compound selected from beta-2 mimetics, steroids, PDE-IV inhibitors, p38 MAP kinase inhibitors, NK1 antagonists and endothelin-antagonists, processes for preparing the compositions and the use thereof as medicament in the treatment of respiratory or gastrointestinal complaints, as well as inflammatory diseases of the joints, the skin or the eyes.

Priority: US2008-0202784 Applic. Date: 2008-09-02; EP2004-0018808 Applic. Date: 2004-08-07; US2005-0189643 Applic. Date: 2005-07-26

Inventor: JUNG BIRGIT (DE); HIMMELSBACH FRANK (DE)

A1 Published: 2009-01-15

Title: PERSONAL CARE KIT HAVING SKIN CARE COMPOSITIONS WITH A READILY PERCEPTIBLE DIFFERENCE

Application No.: US2008-0047391 Applic. Date: 2008-03-13

Abstract: A personal care kit comprises a first series of unit-dose packages containing a first skin care composition and a second series of unit-doses packages containing a second skin care composition, wherein the first skin care composition and the second skin care composition exhibit a readily perceptible difference. The readily perceptible difference may be a visible difference, a tactile difference, or an olfactory difference. The first and/or second skin care composition may comprise a skin care active. A method for using the personal care kit is also disclosed.

Priority: US2008-0047391 Applic. Date: 2008-03-13; US2007-0918216P Applic. Date: 2007-03-15

Inventor: TANNER PAUL ROBERT (US); ROBINSON LARRY RICHARD (US); HA ROBERT BAO (US); ZIMMERMAN DEAN ARTHUR (US)

A1 Published: 2009-01-15

Title: ADJUVANTS ON THE BASIS OF BISACYLOXYPROPYLCYSTENE CONJUGATES AND DERIVATIVES AND THEIR USES IN PHARMACEUTICAL COMPOSITIONS

Application No.: US2006-0093865 Applic. Date: 2006-11-22

Abstract: The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new conjugates of the bisacyloxycysteine type useful as adjuvants and/or immunomodulators for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumours, allergies as well as for the control of fertility in human or animal populations. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants. In addition, the invention relates to its uses as active ingredients in pharmaceutical compositions.

Priority: EP2005-0025431 Applic. Date: 2005-11-22; WO2006-EP11182 Applic. Date: 2006-11-22

Inventor: EBENSEN THOMAS (DE); MORR MICHAEL (DE); GUZMAN CARLOS (DE)

A1 Published: 2009-01-15

Title: Dead Sea minerals enriched anti-inflammatory pharmaceutical composition for treatment of cutaneous dryness, itching, peeling and tightness, especially in hemodialysis patients and preparation and treatment methods thereof

Application No.: US2008-0171076 Applic. Date: 2008-07-10

Abstract: This invention relates to Dead Sea anti-inflammatory medicaments or cosmetics for treatment of anti-inflammatory conditions; for example, cutaneous dryness, itching, peeling, and tightness, especially in hemodialysis patients. Methods for the preparation of and methods of treatment using these medicaments or cosmetics are also provided.

Priority: US2008-0171076 Applic. Date: 2008-07-10; US2007-0929840P Applic. Date: 2007-07-13

Inventor: MA OR ZE EV (IL); ROYZ MICHAEL (IL); MAKOV SHARON (IL); TZIONI TAMAR (IL); MINGELGRIN MIRIAM ORON (IL)

A1 Published: 2009-01-15

Title: Cosmetic or Dermopharmaceutical Composition Comprising an Euglena Extract

Applicant: SEDERMA (FR)

Application No.: US2006-0795330 Applic. Date: 2006-01-13

Abstract: The invention provides a cosmetic or dermopharmaceutic composition containing an Euglena extract, its use to activate the cellular metabolism and in particular to protect and/or improve the state of the skin and to reduce the signs of ageing in particular and/or cutaneous fatigue

Priority: FR2005-0000431 Applic. Date: 2005-01-14; WO2006-IB50135 Applic. Date: 2006-01-13

Inventor: LINTNER KARL (FR); MAS CHAMBERLIN CLAIRE (FR); LAMY LOUIS FRANCOIS (FR); MONDON PHILIPPE (FR)

A1 Published: 2009-01-15

Title: Novel Benzoimidazole Derivatives and Pharmaceutical Composition Comprising the Same

Application No.: US2006-0815009 Applic. Date: 2006-01-26

Abstract: Disclosed herein are novel benzoimidazole derivatives functioning as antagonists to vanilloid receptor-1, and a pharmaceutical composition comprising the same. They are useful in preventing or treating pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraines, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, strokes, bladder hypersensitivity, irritable bowel syndrome, respiratory disorders such as asthma, chronic obstructive pulmonary disease, etc., burns, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases.

Priority: KR2005-0008183 Applic. Date: 2005-01-28; KR2005-0098349 Applic. Date: 2005-10-18; WO2006-KR00324 Applic. Date: 2006-01-27

Inventor: KIM JI DUCK (KR); YOON HONG CHUL (KR); KIM IN WOO (KR); HYUN HYAE JUNG (KR)

A1 Published: 2009-01-15

Title: COMPOSITIONS AND PRODUCTS CONTAINING S-EQUOL, AND METHODS FOR THEIR MAKING

Applicant: AUSTRALIAN HEALTH & NUTRITION (AU); CHILDRENS HOSP MEDICAL CENTER (US)

Application No.: US2008-0167813 Applic. Date: 2008-07-03

Abstract: A composition for use in making commercial food and skin products comprising S-equol or mixtures, including both a non-racemic mixture and a racemic mixture, of S-equol and R-equol. The composition can be used to make articles of commerce such as food supplements, pharmaceuticals, and medicaments. The compositions are useful in a method of delivering S-equol to a mammal to prevent or treat a disease or associated condition, including hormone-dependent diseases or conditions such as cardiovascular disease, lipid disorder, osteopenia, osteoporosis, liver disease, and acute ovarian estrogen deficiency. The S-equol enantiomer can be produced in a biological synthesis from the metabolism of an isoflavone by an organism.

Priority: US2008-0167813 Applic. Date: 2008-07-03; US2003-0625934 Applic. Date: 2003-07-24; US2002-0398270P Applic. Date: 2002-07-24

Inventor: SETCHELL KENNETH DAVID REGINALD (US); COLE SIDNEY JOHN (AU)

A1 Published: 2009-01-15

Title: COMPOSITION CONTAINING A PHENANTHRENOL

Applicant: OREAL (FR)

Application No.: US2008-0172354 Applic. Date: 2008-07-14

Abstract: Novel uses of phenanthrenol compounds for improving the appearance and/or texture of the skin.

Priority: US2008-0172354 Applic. Date: 2008-07-14; US2007-0949295P Applic. Date: 2007-07-12

Inventor: WILLEMIN CLAUDIE (FR); REMAUT GEOFFROY (FR); FONOLLA MORENO ANGELES (FR); LEMOINE CYRIL (FR)

A1 Published: 2009-01-15

Title: Composition for Promoting Vascular Smooth Muscle Relaxation

Application No.: US2007-0223583 Applic. Date: 2007-01-23

Abstract: A composition for topical application to a part of the body comprises a local anaesthetic and optionally a vasodilator as active ingredient dissolved in a blend of volatile and non-volatile solvents of different solvating capacities for the active ingredient. The vasodilator may comprise glyceryl trinitrate and the local anaesthetic may comprises an anaesthetic of the aminoamide or aminoester type. The volatile solvent may comprise a mixture of water with a C1-C5 alcohol and the non-volatile solvent may comprise a polyhydric alcohol and optionally a glycol. A low-concentration vasodilator-containing composition is also described. The compositions allow a "virtual injection" of the active ingredient to be delivered transdermally without general systemic uptake.

Priority: GB2006-0002224 Applic. Date: 2006-02-03; WO2007-GB00212 Applic. Date: 2007-01-23

Inventor: DAVIS ADRIAN FRANCIS (GB)

A1 Published: 2009-01-15

Title: PLASTER WHICH RELEASES ACTIVE COMPOUND

Application No.: US2008-0168938 Applic. Date: 2008-07-08

Abstract: The invention relates to a medical plaster which is able to supply damaged skin and open wounds with an active compound which helps to accelerate wound healing and allows it to proceed better. The plaster has novel design features which enable, in particular, protein- or peptide-containing medicaments, such as, for example, erythro-poietin (EPO), to exert their wound-healing or wound-healing-promoting action by release of the active compound from the plaster without being significantly deactivated or metabolized in the process by substances occurring in the wound secretion.

Priority: EP2007-0013361 Applic. Date: 2007-07-09

Inventor: BADER AUGUSTINUS (DE)

A1 Published: 2009-01-22

Title: COSMETIC OR DERMATOLOGICAL PREPARATIONS COMPRISING OLIGOPEPTIDES FOR LIGHTENING THE SKIN OF AGE MARKS AND/OR FOR PREVENTING TANNING OF THE SKIN, IN PARTICULAR TANNING OF THE SKIN CAUSED BY UV RADIATION

Applicant: BEIERSDORF AG (DE)

Application No.: US2008-0175994 Applic. Date: 2008-07-18

Abstract: Cosmetic or pharmaceutical preparations which are distinguished by an effective content of one or more monomeric or homo- or heterodimeric or homo- or heterotrimeric or homo- or heterotetrameric oligopeptides, where these oligopeptides are based on a Structure Val-Val-Arg-Pro SEQ ID NO: 1 as homo- or heteromonomer.

Priority: US2008-0175994 Applic. Date: 2008-07-18; US1998-0132799 Applic. Date: 1998-08-13

Inventor: SCHONROCK UWE (DE); MAX HEINER (DE); HEARING VINCENT J (US)

A1 Published: 2009-01-22

Title: Cosmetic water-soluble film

Applicant: OREAL (FR)

Application No.: US2008-0081909 Applic. Date: 2008-04-23

Abstract: The present invention relates to a composition which is in the form of a water-soluble anhydrous film comprising at least one water-soluble or water-dispersible film-forming polymer, and at least one live, in particular probiotic, microorganism. It also relates to a kit containing such a composition, as a combination with a secondary composition.

Priority: US2008-0081909 Applic. Date: 2008-04-23; FR2007-0054766 Applic. Date: 2007-04-27; US2007-0941735P Applic. Date: 2007-06-04

Inventor: CASSIN GUILLAUME (FR); SIMONNET JEAN-THIERRY (FR)

A1 Published: 2009-01-22

Title: Compositions and Methods for Inhibiting Leukocyte Function

Applicant: UNIV VIRGINIA (US)

Application No.: US2007-0161915 Applic. Date: 2007-01-24

Abstract: The present invention provides compositions and methods for regulating leukocyte migration and function. The present invention also provides compositions and methods for preventing and inhibiting lung injury and damage associated with neutrophil infiltration of the lung.

Priority: US2007-0161915 Applic. Date: 2007-01-24; US2006-0761471P Applic. Date: 2006-01-24; WO2007-US02077 Applic. Date: 2007-01-24

Inventor: REUTERSHAN JOERG (DE); SCHWARTZ MARTIN A (US); LEY KLAUS F (US); STOCKTON REBECCA A (US)

A1 Published: 2009-01-22

Title: Compositions and Methods for Promoting the Healing of Tissue of Multicellular Organisms

Application No.: US2007-0162990 Applic. Date: 2007-01-31

Abstract: Methods are provided for promoting the healing of tissue of a multicellular organism. The methods can include administering a therapeutically effective amount of a polysulfonated material in a liquid mixture to reduce one or both of inflammation and cancerous cell growth. The methods may alternatively or additionally include internally administering a therapeutically effective amount of a polysulfonated material associated with a solid material to reduce one or both of inflammation and cancerous cell growth. Compositions for healing the tissue of a multicellular organism are provided that can include a sulfonated material in a liquid mixture, as well as solid particles.

Priority: US2007-0162990 Applic. Date: 2007-01-31; US2006-0764033P Applic. Date: 2006-01-31; WO2007-US02780 Applic. Date: 2007-01-31

Inventor: VACHON DAVID (US)

A1 Published: 2009-01-22

Title: BACTERIAL EXTRACTS CULTURED IN THERMAL WATERS FOR THE TREATMENT OF DRY SKIN

Applicant: OREAL (FR)

Application No.: US2008-0175072 Applic. Date: 2008-07-17

Abstract: Dryness of keratin materials, in particular dryness of the skin, and especially disorders associated with dry and/or hyposeborrheic skin are treated by administering to individuals afflicted therewith, thus effective amounts of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which includes at least one non-sulfurous mineral and/or thermal water, e.g., an extract derived from the bacterium Vitreoscilla filiformis, in particular the strain ATCC 15551, cultured in a medium enriched with water from La Roche Posay.

Priority: US2008-0175072 Applic. Date: 2008-07-17; FR2007-0056531 Applic. Date: 2007-07-17; US2007-0929966P Applic. Date: 2007-07-19

Inventor: GUENICHE AUDREY (FR); BRETON LIONEL (FR)

A1 Published: 2009-01-22

Title: Cosmetic Composition and a Process for Preparing This Cosmetic Composition and a Cosmetic Product

Application No.: US2005-0794428 Applic. Date: 2005-12-28

Abstract: The present invention relates to a cosmetic composition comprising: a wetting system that comprises at least glycerin in an amount ranging from 8.0% to 10% by weight, based on the total weight of the composition; an emollient system that comprises at least cetyl lactate and Shea butter; an emulsifying system that comprises at least steareth-2 and steareth-21; an oiliness adsorbing system that comprises at least nylon 12; and a silicone system that comprises at least cyclomethicone and cyclomethicone and dimethicone crosspolymer. This multifunctional cosmetic composition exhibits rapid absorption, properties of differentiated softness, smoothness and intensive and prolonged hydration when applied to the skin. Further, the present invention relates to a process of preparing the referred-to cosmetic composition and to a cosmetic product that comprises said composition.

Priority: BR2004-PI05956 Applic. Date: 2004-12-29; WO2005-BR00262 Applic. Date: 2005-12-28

Inventor: SILVA LUCIANA VILLA NOVA (BR); SILVA ALEXANDRE ROBERTO (BR); BRAZ THIAGO (BR)

A1 Published: 2009-01-29

Title: BACTERIAL EXTRACTS CULTURED IN THERMAL WATERS COMPRISING ANTI-REDNESS AGENTS

Applicant: OREAL (FR)

Application No.: US2008-0175108 Applic. Date: 2008-07-17

Abstract: Red blotches on the skin such as those associated with environmental stresses, or red blotches associated with a skin disorder, for example those occurring during rosacea, are treated/reduced by administering to individuals afflicted therewith, thus effective amounts of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which includes at least one non-sulfurous mineral and/or thermal water, e.g., an extract derived from the bacterium Vitreoscilla filiformis, in particular the strain ATCC 15551, cultured in a medium enriched with water from La Roche Posay.

Priority: US2008-0175108 Applic. Date: 2008-07-17; FR2007-0056532 Applic. Date: 2007-07-17; US2007-0935007P Applic. Date: 2007-07-20

Inventor: GUENICHE AUDREY (FR); BRETON LIONEL (FR)

A1 Published: 2009-01-29

Title: Compositions and methods for soft tissue augmentation

Application No.: US2008-0220420 Applic. Date: 2008-07-24

Abstract: The present invention provides compositions comprising isolated human collagen, isolated human elastin and a pharmaceutically acceptable carrier wherein the human elastin is substantially insoluble in water with a molecular weight greater than 100 kDa. The present invention further provides methods and kits for soft tissue augmentation.

Priority: US2008-0220420 Applic. Date: 2008-07-24; US2007-0962289P Applic. Date: 2007-07-27

Inventor: NIKLASON LAURA (US); LI YULING (US); BLUM JULIANA (US); DAHL SHANNON (US); ERICKSON GEOFFREY (US); ZEIGLER FRANK (US)

A1 Published: 2009-01-29

Title: BACTERIAL EXTRACTS CULTURED IN THERMAL WATERS FOR REDUCING BAGS AND/OR DARK CIRCLES AROUND THE EYES

Applicant: OREAL (FR)

Application No.: US2008-0175119 Applic. Date: 2008-07-17

Abstract: Bags and/or dark circles around the eyes of individuals afflicted therewith are reduced by administering to such individuals thus effective amounts of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which includes at least one non-sulfurous mineral and/or thermal water, e.g., an extract derived from the bacterium Vitreoscilla filiformis, in particular the strain ATCC 15551, cultured in a medium enriched with water from La Roche Posay.

Priority: FR2007-0056535 Applic. Date: 2007-07-17; US2008-0175119 Applic. Date: 2008-07-17; US2007-0929970P Applic. Date: 2007-07-19

Inventor: BRETON LIONEL (FR); GUENICHE AUDREY (FR)

A1 Published: 2009-01-29

Title: INHIBITORS OF AKT/PKB WITH ANTI-TUMOR ACTIVITY

Applicant: UNIV SOUTH FLORIDA (US)

Application No.: US2008-0172831 Applic. Date: 2008-07-14

Abstract: The subject invention concerns materials and methods for inhibiting the Akt/PKB pathway. In one embodiment, a compound of the invention inhibits kinase activity and/or phosphorylation levels of Akt proteins. The subject invention also concerns methods for inhibiting or killing a cancer cell or other cell in which expression of an Akt protein is elevated or constitutively active, comprising contacting the cell with an effective amount of a compound of formula I. The subject invention also concerns methods for treating cancer or a tumor in a person or animal comprising administering all effective amount of a compound of formula I to the person or animal.

Priority: US2008-0172831 Applic. Date: 2008-07-14; US2007-0949365P Applic. Date: 2007-07-12

Inventor: CHENG JIN Q (US); SUN MEI (US); SEBTI SAID M (US)

A1 Published: 2009-01-29

Title: COSMETIC USE OF AN ACTIVE AGENT CAPABLE OF STIMULATING TENSIN 1 EXPRESSION

Applicant: CHANEL PARFUMS BEAUTE (FR)

Application No.: US2008-0128891 Applic. Date: 2008-05-29

Abstract: A cosmetic skincare process intended to prevent and/or treat at least one cutaneous sign of aging, includes the topical application to the skin of a composition containing at least one active agent capable of stimulating tensin 1 expression. The cosmetic use of an active agent capable of stimulating tensin 1 expression, for preventing and/or treating at least one cutaneous sign of aging, an extract of elemi or of Canarium indicum L. or of Canarium luzonicum or of Canarium commune and a cosmetic composition containing the extract are also disclosed.

Priority: US2008-0128891 Applic. Date: 2008-05-29; FR2007-0003790 Applic. Date: 2007-05-29; US2007-0941730P Applic. Date: 2007-06-04

Inventor: MAESTRO YANNICK (FR); SAINTIGNY GAELLE (FR); BERNARD FRANCOIS XAVIER (FR)

A1 Published: 2009-01-29

Title: Transdermal Patch

Applicant: BOUTY S P A

Application No.: US2006-0886705 Applic. Date: 2006-09-22

Abstract: A transdermal patch suitable for the administration of nitroglycerin.

Priority: IT2005-MI00477 Applic. Date: 2005-03-23; WO2006-EP60930 Applic. Date: 2006-03-22

Inventor: STEFANELLI PAOLA (IT); COMUZIO SERGIO (IT)

A1 Published: 2009-01-29

Title: Compostion for treating skin

Application No.: US2008-0229621 Applic. Date: 2008-08-26

Abstract: A combination comprising verbascoside and luteolin, and its use in a cosmetic or pharmaceutical composition for pigmentation modulation.

Priority: EP2006-0290343 Applic. Date: 2006-02-28; WO2007-EP01459 Applic. Date: 2007-02-21

Inventor: SENE GERARD (FR); LOISEAU ALAIN (FR); PETIT VIRGINIE (FR); THERON ERIC (FR); SEGOND CAROLINE (FR)

A1 Published: 2009-01-29

Title: PEPTIDES FOR BINDING CALCIUM CARBONATES AND METHODS OF USE

Application No.: US2007-0828539 Applic. Date: 2007-07-26

Abstract: Combinatorially generated peptides are provided that have binding affinity for calcium carbonates. The peptides may be used to deliver benefit agents to various calcium carbonate surfaces.

Priority: US2007-0828539 Applic. Date: 2007-07-26

Inventor: CUNNINGHAM SCOTT D (US); ITTEL STEVEN DALE (US); O'BRIEN JOHN P (US); ROUVIERE PIERRE E (US)

A1 Published: 2009-01-29

Title: SUBSTITUTED PYRAZOLE COMPOUNDS

Application No.: US2008-0137355 Applic. Date: 2008-06-11

Abstract: Disclosed are protein kinase inhibitors, compositions comprising such inhibitors, and methods of use thereof. More particularly, disclosed are inhibitors of Aurora A (Aurora-2) protein kinase. Also disclosed are methods of treating diseases associated with protein kinases, especially diseases associated with Aurora-2, such as cancer.

Priority: US2008-0137355 Applic. Date: 2008-06-11; US2007-0934062P Applic. Date: 2007-06-11; US2007-0990475P Applic. Date: 2007-11-27

Inventor: AGOSTON GREGORY E (US); TRESTON ANTHONY M (US); LADOUCEUR GAETAN (US); SUWANDI LITA (US)

A1 Published: 2009-02-05

Title: Cosmetic composition for combating the cutaneous consequences of pollution

Application No.: US2006-0918860 Applic. Date: 2006-04-21

Abstract: The invention relates to the use of the extracts of plants of the genus Lapsana and of the species Lapsana communis L (Asteraceae) in particular. Said extracts are preferably obtained by maceration in a hydroglycolic mixture, and are used in cosmetic or dermopharmaceutical preparations for their skin-protective and radical-resistant properties. The actions of such preparations produce anti-ageing and anti-wrinkle effects, and protect the basic constituents of the cutaneous structure from the harsh effects of oxygen free radicals while prolonging the skin's suppleness and protective function. Said compositions supply protective cellular action against the deleterious effects of free radicals and those of enzymes such as elastase and hyaluronidase.

Priority: FR2005-0051037 Applic. Date: 2005-04-22; WO2006-FR00896 Applic. Date: 2006-04-21

Inventor: COURTIN OLIVIER (FR)

A1 Published: 2009-02-05

Title: Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And An Oil Phase Structuring Agent

Application No.: US2008-0127382 Applic. Date: 2008-05-27

Abstract: An emulsion cosmetic composition comprising at least one resveratrol derivative, an aqueous phase, and an oil phase having at and at least one oil phase structuring agent, and a method for preparing emulsions capable of delivering active resveratrol to the skin.

Priority: US2008-0127382 Applic. Date: 2008-05-27; US2007-0952874P Applic. Date: 2007-07-31

Inventor: MAES DANIEL H (US); MOHAMMADI FATEMEH (US); QU LISA (US); CZARNOTA ANNA (US); WAMMONE THOMAS (US); DECLERCQ LIEVE (BE); ZECCHINO JULIUS R (US)

A1 Published: 2009-02-05

Title: Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And Silicone Surfactant

Application No.: US2008-0127414 Applic. Date: 2008-05-27

Abstract: An emulsion cosmetic composition comprising at least one resveratrol derivative, an aqueous phase, and an oil phase, having at least one silicone surfactant, and a method for preparing emulsions capable of delivering active resveratrol to the skin.

Priority: US2008-0127414 Applic. Date: 2008-05-27; US2007-0952878P Applic. Date: 2007-07-31

Inventor: MAES DANIEL H (US); MOHAMMADI FATEMEH (US); QU LISA (US); CZARNOTA ANNA (US); MAMMONE THOMAS (US); DECLERCQ LIEVE (BE); ZECCHINO JULIUS R (US)

A1 Published: 2009-02-05

Title: Aqueous Based Cosmetic Compositions Containing Resveratrol Derivatives And An Aqueous Phase Structuring Agent

Application No.: US2008-0127399 Applic. Date: 2008-05-27

Abstract: An aqueous based cosmetic composition comprising at least one resveratrol derivative and a water phase containing at least one aqueous phase structuring agent; or an emulsion composition comprising at least one water phase, at least one oil phase containing at least one nonvolatile silicone, and at least one resveratrol derivative.

Priority: US2008-0127399 Applic. Date: 2008-05-27; US2007-0952877P Applic. Date: 2007-07-31

Inventor: MAES DANIEL H (US); MOHAMMADI FATEMEH (US); QU LISA (US); CZARNOTA ANNA (US); MAMMONE THOMAS (US); DECLERCO LIEVE (BE); ZECCHINO JULIUS R (US)

A1 Published: 2009-02-05

Title: Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And Linear Or Branched Silicone

Application No.: US2008-0127439 Applic. Date: 2008-05-27

Abstract: An emulsion cosmetic composition comprising at least one resveratrol derivative, a water phase, and an oil phase containing at least one linear or branched volatile or near volatile silicone and a method for delivering active resveratrol to the skin.

Priority: US2008-0127439 Applic. Date: 2008-05-27; US2007-0952881P Applic. Date: 2007-07-31

Inventor: MAES DANIEL H (US); MOHAMMADI FATEMEH (US); QU LISA (US); CZARNOTA ANNA (US); MAMMONE THOMAS (US); DECLERCQ LIEVE (BE); ZECCHINO JULIUS R (US)

A1 Published: 2009-02-05

Title: METHOD OF STABILIZING A POLYSILOXANE EMULSION AND COMPOSITIONS CONTAINING STABILIZED EMULSIONS

Application No.: US2007-0831858 Applic. Date: 2007-07-31

Abstract: A method of stabilizing an emulsion containing a polysiloxane and one or more surfactants comprising adding an effective amount of dispersion containing a DADMAC/acrylamide copolymer and one or more sulfate salts into said emulsion is disclosed. An emulsion/cosmetically acceptable emulsion comprising a polysiloxane, at least one surfactant, and a dispersion containing DADMAC/acrylamide copolymer and one or more sulfate salts is also disclosed.

Priority: US2007-0831858 Applic. Date: 2007-07-31

Inventor: GABELNICK STEPHANIE E (US); HOSOKAWA MINORU (JP); YOKOMAKU ATSUSHI (JP); KASHIWAI TOSHIYUKI (JP)

A1 Published: 2009-02-05

Title: IL-17 homologous polypeptides and therapeutic uses thereof

Application No.: US2008-0214762 Applic. Date: 2008-06-19

Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and hosT-cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

Priority: US2008-0214762 Applic. Date: 2008-06-19; US2003-0458573 Applic. Date: 2003-06-10; US2001-0874503 Applic. Date: 2001-06-05; US2001-0816744 Applic. Date: 2001-03-22; WO2001-US06520 Applic. Date: 2001-02-28; US2000-0747259 Applic. Date: 2000-12-20; WO2000-US23328 Applic. Date: 2000-08-24; US2000-0191007P Applic. Date: 2000-03-21

Inventor: CHEN JIAN (US); FILVAROFF ELLEN (US); FONG SHERMAN (US); GODDARD AUDREY (US); GODOWSKI PAUL (US); GRIMALDI J CHRISTOPHER (US); GUMEY AUSTIN (US); LI HANZHONG (US); HILLAN KENNETH (US); HYMOWITZ SARAH G (US); TUMAS DANIEL (US); STAROVASNIK MELISSA A (US); VANLOOKEREN MENNO (US); VANDLEN RICHARD (US); WATANABE COLIN (US); WILLIAMS P MICKEY (US); WOOD WILLIAM I (US); YANSURA DANIEL (US)

A1 Published: 2009-02-05

Title: TREATMENT AND/OR PREVENTION OF CANCER AND/OR ARTHRITIS

Applicant: SERONO LAB (CH)

Application No.: US2006-0912432 Applic. Date: 2006-04-20

Abstract: The invention relates to the use of INSP163 for treatment and/or prevention of cancer and/or musculoskeletal/connective tissue disorder, in particular of lung cancer and/or osteoarthritis. Combinations of INSP163 with an interferon, a TNF antagonist or a further anti-cancer or anti-arthritis agent are also within the present invention.

Priority: US2006-0912432 Applic. Date: 2006-04-20; EP2005-0103402 Applic. Date: 2005-04-26; US2005-0681731P Applic. Date: 2005-05-17; WO2006-EP61710 Applic. Date: 2006-04-20

Inventor: POWER CHRISTINE (FR); YORKE-SMITH MELANIE (GB)

A1 Published: 2009-02-05

Title: LIPOPOLYSACCHARIDE FRACTIONS OF VITREOSCILLA FILIFORMIS USEFUL FOR STIMULATING THE SYNTHESIS OF ANTI-MICROBIAL PEPTIDES OF THE SKIN

Applicant: OREAL (FR)

Application No.: US2008-0055975 Applic. Date: 2008-03-26

Abstract: Specific fractions of Vitreoscilla filiformis comprising its Lipid A are useful for stimulating the synthesis of anti-microbial peptides of the skin.

Priority: US2008-0055975 Applic. Date: 2008-03-26; FR2007-0054039 Applic. Date: 2007-03-26; US2007-0907507P Applic. Date: 2007-04-05

Inventor: MAHE YANN (FR); MARTIN RICHARD (FR)

A1 Published: 2009-02-05

Title: Compounds

Applicant: PFIZER

Application No.: US2004-0564693 Applic. Date: 2004-07-13

Abstract: This invention relates to nicotinamide derivatives of general formula (I): in which R1, Z and R2 have the meanings defined herein, and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of such derivatives.

Priority: GB2003-0017498 Applic. Date: 2003-07-25; WO2004-IB02380 Applic. Date: 2004-07-13

Inventor: BARBER CHRISTOHPER GORDON (GB); BUNNAGE MARK EDWARD (GB); HARVEY JOHN WILSON (GB); MATHIAS JOHN PAUL (GB)

A1 Published: 2009-02-05

Title: User-adjustable treatment methods, systems and compositions for treating acne

Application No.: US2006-0450881 Applic. Date: 2006-06-09

Abstract: Methods, apparatus, systems and the like for treating acne vulgaris that improves treatment effectiveness and/or reduces bothersome side effects associated with the ingredients used. The present Methods, apparatus, systems, etc., also provide topical compositions of benzoyl peroxide and/or other anti-acne agents that are useful for treating acne vulgaris and may be used simultaneously or sequentially in a user-adjustable ratio of two or more such compositions, or other compositions as desired such as cleansers or lotions.

Priority: US2006-0450881 Applic. Date: 2006-06-09; US2005-0732785P Applic. Date: 2005-11-01

Inventor: WILKINSON RANDALL (US)

A1 Published: 2009-02-05

Title: THREE-DIMENSIONAL RECONSTITUTED EXTRACELLULAR MATRICES AS SCAFFOLDS FOR TISSUE ENGINEERING

Applicant: AGENCY SCIENCE TECH & RES (SG)

Application No.: US2006-0095486 Applic. Date: 2006-12-01

Abstract: A biomaterial scaffold comprising: a) reconstituted extracellular matrix; and b) polyelectrolyte complex fibers; wherein the matrix and the fibers are functionally associated.

Priority: US2006-0095486 Applic. Date: 2006-12-01; US2005-0741370P Applic. Date: 2005-12-01; WO2006-SG00376 Applic. Date: 2006-12-01

Inventor: YING JACKIE Y (SG); LECK KWONG JOO (SG); WAN ANDREW C A (SG)

A1 Published: 2009-02-12

Title: Wax Foamable Vehicle and Pharmaceutical Compositions Thereof

Applicant: FOAMIX LTD (IL)

Application No.: US2008-0187840 Applic. Date: 2008-08-07

Abstract: Unique foamable vehicles or carriers comprising at least one wax, waxy substance, counterpart or derivative, a stabilizer, water, and a propellant are provided. In some embodiments, the wax is a liquid wax. In some embodiments, the wax includes a solid wax and a liquid wax. The compositions are substantially free of crystals. The components are selected to provide a composition that is substantially resistant to aging and to phase separation, and/or can substantially solubilize and or stabilize active ingredients. Pharmaceutical and cosmetic compositions with potentially enhanced skin delivery and their uses are also provided.

Priority: US2008-0187840 Applic. Date: 2008-08-07; US2007-0954525P Applic. Date: 2007-08-07

Inventor: TAMARKIN DOV (IL); KEYNAN RITA (IL); SCHUZ DAVID (IL); BERMAN TAL (IL)

A1 Published: 2009-02-12

Title: Cosmetic Delivery System and Process for Manufacture Thereof

Application No.: US2006-0887353 Applic. Date: 2006-03-13

Abstract: A benefit agent delivery system for use in cosmetic or cleansing products is provided comprising a polysaccharide-zein complex, a benefit agent and a plasticiser. The delivery system enhances the stability of the benefit agent whilst providing for shear-triggered release of the benefit agent on application of a product to a substrate such as human skin. Also provided is a process for the preparation of the benefit agent delivery system.

Priority: IN2005-MU00368 Applic. Date: 2005-03-30; IN2005-MU00369 Applic. Date: 2005-03-30; EP2005-0256274 Applic. Date: 2005-10-07; WO2006-EP02301 Applic. Date: 2006-03-13

Inventor: BAVISKAR RAJESH JANARDAN (IN); KINI MRIDULA (IN); PRADHAN RAM RAMESH (IN); SURIANARAYANAN RAMESH (IN)

A1 Published: 2009-02-12

Title: Sunless tanning compositions comprising certain substituted polyamine compounds and methods of use

Application No.: US2008-0220158 Applic. Date: 2008-07-22

Abstract: The present invention is directed to cosmetic and/or dermatological compositions for enhancing the rate of tanning human skin with sunless tanning compositions and providing the added benefit of simultaneously providing protection from ultraviolet light radiation. More particularly, the present invention is directed to a sunless tanning composition comprising a sunless tanning agent, a substituted polyamine compound and a cosmetically acceptable adjuvant. Methods of use of the instant compositions are disclosed as well.

Priority: US2008-0220158 Applic. Date: 2008-07-22; US2007-0962359P Applic. Date: 2007-07-27

Inventor: DUEVA-KOGANOV OLGA (US); ZHOU XIAN-ZHI (US); BARKER SHAUN (US); JENNINGS JOHN (IE)

A1 Published: 2009-02-12

Title: Sun protection compositions comprising semi-crystalline polymers and hollow latex particles

Applicant: OREAL (FR)

Application No.: US2008-0216527 Applic. Date: 2008-07-07

Abstract: Topically applicable cosmetic/dermatological UV protection compositions having enhanced SPF contain at least one organic UV screening agent and/or at least one inorganic screening agent, such compositions also containing at least the following constituents (A) and (B): A) a semi-crystalline polymer which is solid at ambient temperature and has a melting point of greater than or equal to 30 DEG C., containing a) a polymeric backbone and b) at least one crystallizable organic side chain and/or one crystallizable organic block forming part of the backbone of this said polymer, said polymer having a number-average molecular mass Mn of greater than or equal to 1,000, and B) hollow latex particles having a particle size ranging from 150 to 380 nm, formulated into a topically applicable, physiologically acceptable medium therefor.

Priority: US2008-0216527 Applic. Date: 2008-07-07; FR2007-0056322 Applic. Date: 2007-07-06; US2007-0929964P Applic. Date: 2007-07-19

Inventor: CANDAU DIDIER (FR); BOUTELET KARL (FR)

A1 Published: 2009-02-12

Title: CANCER TREATMENT BY METABOLIC MODULATIONS

Applicant: ENGENE INC (CA)

Application No.: US2008-0017902 Applic. Date: 2008-01-22

Abstract: The invention provides compositions and methods for inhibiting the growth or proliferation of hyperproliferative cells or inducing regression of hyperproliferative cells. More specifically, the invention provides compositions and methods for stimulating glycogen accumulation in target cells (e.g., hyperproliferative cells) in order to increase glycogen to a level that is toxic to the target cell.

Priority: US2008-0017902 Applic. Date: 2008-01-22; US2007-0983021 Applic. Date: 2007-11-05; US2003-0697700 Applic. Date: 2003-10-29; US2002-0422365P Applic. Date: 2002-10-29

Inventor: POWNALL SCOTT (CA); CHEUNG ANTHONY T (CA); HSU ERIC C (CA); DOIRON BRUNO (CA)

A1 Published: 2009-02-12

Title: Aldosterone induced elastin production

Application No.: US2008-0157141 Applic. Date: 2008-06-06

Abstract: Compositions and methods for inducing the deposition of elastin in skin by administering compositions including a mineralocorticoid, such as, for example, aldosterone and, optionally, a secondary active agent for enhancing or modulating the effect of the mineralocorticoid are described herein.

Priority: US2008-0157141 Applic. Date: 2008-06-06; US2007-0942305P Applic. Date: 2007-06-06

Inventor: MITTS THOMAS F (US); HINEK ALEKSANDER (CA)

A1 Published: 2009-02-12

Title: SKIN ANTI-AGING AGENT FOR EXTERNAL USE

Applicant: FUJIFILM CORP (JP)

Application No.: US2008-0060392 Applic. Date: 2008-04-01

Abstract: It is an object of the present invention to provide a skin anti-aging agent for external use which comprises highly safe protein nanoparticles having high transparency due to the small particle size and high permeability into skin. The present invention provides a skin anti-aging agent for external use, which comprises protein nanoparticles containing an active ingredient.

Priority: JP2007-0096192 Applic. Date: 2007-04-02

Inventor: AIMI MAKIKO (JP); OGIWARA KAZUTAKA (JP); AMANO TAKUO (JP)

A1 Published: 2009-02-12

Title: ABNORMAL PROTEIN REMOVING COMPOSITION

Application No.: US2006-0088919 Applic. Date: 2006-07-20

Abstract: It is an object of the present invention to efficiently remove abnormal protein produced in living tissues, especially skin, due to exposure to UV light, etc. A composition for removing abnormal protein containing one or two or more substances selected from silybin, Bletilla striata extract and Iris sanguinea extract.

Priority: JP2005-0289491 Applic. Date: 2005-10-03; WO2006-JP314403 Applic. Date: 2006-07-20

Inventor: MIYATA SATOSHI (JP); UMINO YUKARI (JP)

A1 Published: 2009-02-12

Title: Anti-wrinkle composition

Applicant: SHISEIDO CO LTD (JP)

Application No.: US2006-0918424 Applic. Date: 2006-04-12

Abstract: There is provided a novel anti-wrinkle composition comprising one or more from among watercress, juniper, baizhu and coltsfoot extracts as active ingredients.

Priority: JP2005-0116061 Applic. Date: 2005-04-13; WO2006-JP308163 Applic. Date: 2006-04-12

Inventor: TAKADA KEIKO (JP); INOMATA SHINJI (JP); OGURA YUKI (JP); UMISHIO KENICHI (JP)

A1 Published: 2009-02-12

Title: Solid Textile Care Composition Comprising A Water-Soluble Polymer

Applicant: HENKEL AG & CO KGAA (DE)

Application No.: US2008-0246129 Applic. Date: 2008-10-06

Abstract: A solid textile care composition having a water-soluble carrier, a water-soluble polymer, a textile care compound and a perfume. A solid textile care composition in which the water-soluble carrier is present in particulate form and has an envelope composed of the water-soluble polymer, the textile care compound and the perfume. Also textile care washing or cleaning compositions comprising the textile care composition.

Priority: DE2006-10016578 Applic. Date: 2006-04-06; WO2007-EP52129 Applic. Date: 2007-03-07

Inventor: MAYER KONSTANZE (DE); SCHEFFLER KARL-HEINZ (DE); ARTIGA-GONZALEZ RENE-ANDRES (DE); HARTH HUBERT (DE); STURM MARIO (DE); SEGLER TOBIAS (DE); TIGGES DANIEL (DE)

A1 Published: 2009-02-12

Title: Peptides Useful As Dual Caspase-2/-6 Inhibitors And Their Biological Applications

Application No.: US2005-0791469 Applic. Date: 2005-11-24

Abstract: The invention relates to peptides having a core sequence selected in the group comprising: SEQ ID No.1: VDEAD, SEQ ID No.2: LDEGD, SEQ ID No.3: VDEGD, SEQ ID No.4: VDESD, SEQ ID No.5: LDEKD, SEQ ID No.6: FDESD, SEQ ID No.7: LDEAD, application as inhibitors of caspase-2 and/or -6 activity.

Priority: US2005-0791469 Applic. Date: 2005-11-24; US2004-0630249P Applic. Date: 2004-11-24; WO2005-EP13976 Applic. Date: 2005-11-24

Inventor: CHAUVIER DAVID (FR); CASIMIR RICHARD (FR); HOEBEKE JOHAN (BE)

A1 Published: 2009-02-12

Title: 17ALPHA-SUBSTITUTED STEROIDS AS SYSTEMIC ANTIANDROGENS AND SELECTIVE ANDROGEN RECEPTOR MODULATORS

Applicant: ENDORECH INC

Application No.: US2008-0100372 Applic. Date: 2008-04-09

Abstract: Compounds having the structure, their salts or N-oxide derivatives: are used to treat or reduce le likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and male baldness. They can be formulated together with pharmaceutically acceptable diluent or carrier or otherwise made into any pharmaceutical dosage form. Combinations with other active pharmaceutical agents are also disclosed.

Priority: US2008-0100372 Applic. Date: 2008-04-09; US2007-0911434P Applic. Date: 2007-04-12; US2007-0911452P Applic. Date: 2007-04-12

Inventor: LABRIE FERNAND (CA); GAUTHIER SYLVAIN (CA); CLOUTIER JULIE (CA); MAILHOT JOSEE (CA); POTVIN STEEVES (CA); DION SYLVAIN (CA); SANCEAU JEAN-YVES (CA)

A1 Published: 2009-02-12
Patent No.: US7615546B2 Issued: 2009-11-10

Title: Topical Delivery System for Phytosterols

Applicant: BIODERM RES (US)

Application No.: US2008-0210266 Applic. Date: 2008-09-15

Abstract: This invention relates to certain sugar esters of phytosterols of formula (I). These esters are useful for topical application, and for the treatment of skin condition, including age spots, acne, loss of cellular antioxidants, collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from radiation, malfunction of matrix metalloproteases, malfunction of tyrosinases, damage from free radicals, damage from UV, dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, liver spots, pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, topical inflammation, disturbed keratinization, skin changes associated with aging, nail or skin requiring cleansers, conditioning or treatment, and hair or scalp requiring shampooing or conditioning, and combinations thereof; Wherein, n=0, 1, 2, or 3; and R=H, -CH2OH, -CH(OH)-CH2OH, -CH(OH)-CH(OH)-CH2OH; and R1=Substituent selected from a sapogenin, steroid, or terpenoid.

Priority: US2008-0210266 Applic. Date: 2008-09-15; US2005-0161856 Applic. Date: 2005-08-19; US2008-0139659 Applic. Date: 2008-06-16

Inventor: GUPTA SHYAM K (US)

A1 Published: 2009-02-12

Title: Method of Treating Tumors with Azaxanthones

Application No.: US2008-0255141 Applic. Date: 2008-10-21

Abstract: The use of azaxanthones for treating diseases associated with tumor cells which express one or more protein of S100 family, and in treating patients that have malignancies consisting of tumors of an epithelial or mesenchymal nature, where these compounds are effective in retarding the progression and/or metastasis of these tumors.

Priority: US2008-0255141 Applic. Date: 2008-10-21; US2005-0301930 Applic. Date: 2005-12-13

Inventor: SEMOV ALEXANDRE (CA); PIETRZYNSKI GRZEGORZ (CA); ALAKHOV VALERY (CA)

A1 Published: 2009-02-12

Title: TRANSDERMAL TOPICAL COMPOSITION AND ITS USES

Applicant: TRANSPHASE LTD (GB)

Application No.: US2006-0909061 Applic. Date: 2006-03-22

Abstract: At least one silicone is used to modify the release profile of the active compound(s) in a therapeutic composition for topical application the skin that also comprises at least one penetration enhancer and a fugitive solvent base.

Priority: GB2005-0006139 Applic. Date: 2005-03-24; WO2006-GB01063 Applic. Date: 2006-03-22

Inventor: PANDYA ANANT K (GB)

A1 Published: 2009-02-12

Title: MICRONEEDLE ARRAYS FORMED FROM POLYMER FILMS

Application No.: US2008-0187268 Applic. Date: 2008-08-06

Abstract: The present invention provides for transdermal delivery devices having microneedle arrays, as well as methods for their manufacture and use. In one embodiment, a transdermal delivery device is provided. The transdermal delivery device includes a polymer layer which has microneedles projecting from one of its surfaces. The microneedles are compositionally homogenous with the polymer base layer.

Priority: US2008-0187268 Applic. Date: 2008-08-06; US2007-0963725P Applic. Date: 2007-08-06; US2007-0994568P Applic. Date: 2007-09-19

Inventor: KASPAR ROGER L (US); SPEAKER TYCHO (US)

A1 Published: 2009-02-19

Title: Cosmetic Process for Preventing or Treating the Signs of Skin Ageing or the Orange-Peel Appearance

Applicant: OREAL (FR)

Application No.: US2004-0580230 Applic. Date: 2004-11-08

Abstract: The present invention relates to the use of at least one compound capable of cleaving the diketone crosslinking bonds between two proteins, in a composition applied topically to the skin, as an agent for preventing or treating the signs of ageing of the skin or the orange-peel appearance. The above compound is preferably a N-hydroxy imide of formula (I). These N-hydroxy imides have inhibitory properties on the glycation of proteins and also antioxidant properties. The invention also relates to novel N-hydroxy imides included in formula (I) above.

Priority: US2004-0580230 Applic. Date: 2004-11-08; FR2003-0050870 Applic. Date: 2003-11-20; FR2004-0008987 Applic. Date: 2004-08-19; US2004-0544320P Applic. Date: 2004-02-17; WO2004-EP12699 Applic. Date: 2004-11-08

Inventor: DALKO MARIA (FR); PAGEON HERVE (FR)

A1 Published: 2009-02-19

Title: Cationic Cassia Derivatives and Applications Therefor

Application No.: US2008-0254437 Applic. Date: 2008-10-20

Abstract: This invention relates to cationically derivatized polycalactomannans obtained from cassia tora and cassia obtusifolia and to their use in personal care, household care, and institutional care compositions.

Priority: US2008-0254437 Applic. Date: 2008-10-20; US2007-0843920 Applic. Date: 2007-08-23; US2004-0874296 Applic. Date: 2004-06-18; US2003-0479793P Applic. Date: 2003-06-19

Inventor: LEPILLEUR CAROLE A (US)

A1 Published: 2009-02-19

Title: COSMETIC METHODS AND COMPOSITIONS FOR REPAIRING HUMAN SKIN

Application No.: US2007-0837658 Applic. Date: 2007-08-13

Abstract: The present invention relates to methods and compositions for repairing adverse effects of the environment, daily stress, sun exposure, or pre-mature aging on human skin, comprising applying to the skin, prior to a period of bodily rest, a topical composition that contains resveratrol or a derivative thereof and at least one DNA repair enzyme.

Priority: US2007-0837658 Applic. Date: 2007-08-13

Inventor: MAES DANIEL H (US); MAMMONE THOMAS (US); GOLDGRABEN KERRI (US)

A1 Published: 2009-02-19

Title: Use of a griffonia extract, in particular griffonia simplicifolia, in a cosmetic or dermatological composition for mitigating pigmentation of skin and skin appendages

Application No.: US2006-0921943 Applic. Date: 2006-05-24

Abstract: Use of an extract of Griffonia, in particular of Griffonia simplicifolia, in a cosmetic or dermatological preparation for attenuating the pigmentation of the skin and of superficial body growths. This cosmetic or dermatological preparation may also contain any of the following products: at least one other active depigmenting product, at least one substance for filtering or blocking B and/or A ultraviolet radiation, at least one anti-inflammatory product, at least one agent encouraging flaking. It contains from 0.05 to 20% by weight of an extract of Griffonia simplicifolia.

Priority: FR2005-0005958 Applic. Date: 2005-06-13; WO2006-FR01181 Applic. Date: 2006-05-24

Inventor: MEYBECK ALAIN (FR)

A1 Published: 2009-02-19

Title: Porous particles loaded with cosmetically or pharmaceutically active compounds

Applicant: OREAL (FR)

Application No.: US2008-0285297 Applic. Date: 2008-10-01

Abstract: Individualized porous particles have a volume-average diameter of less than or equal to 10 mum and a specific surface area of greater than or equal to 1 m2/g, and include at least one cosmetically or pharmaceutically active compound present at least inside the particles.

Priority: US2008-0285297 Applic. Date: 2008-10-01; FR2003-0007747 Applic. Date: 2003-06-26; US2004-0876527 Applic. Date: 2004-06-28; US2003-0487245P Applic. Date: 2003-07-16

Inventor: SIMONNET JEAN-THIERRY (FR); BIATRY BRUNO (FR); SAINT-LEGER DIDIER (FR)

A1 Published: 2009-02-19

Title: Oral fast dissolving films for erectile dysfunction bioactive agents

Application No.: US2008-0228702 Applic. Date: 2008-10-09

Abstract: A novel edible polymer based film dosage form manufactured using natural, synthetic, semisynthetic, pharmaceutically acceptable polymers addressing the issues of swallowing difficulties (Dysphagia and Dynaphagia), of tablet or capsule dosage forms and handling and storage difficulties associated with liquid dosage forms, that also includes materials such as emulsifying agents, suspending agents, buffering agents, effervescence agents, colorants, flavorants, sweeteners and specified amounts of bioactive agents, for erectile dysfunction. A flexible film dosage form containing sildenafil citrate, tadalafil or Vardenafil is presented. The film system is enabled to be used in various applications such as oral, mucosal and external environments.

Priority: US2008-0228702 Applic. Date: 2008-10-09; US2007-0965047P Applic. Date: 2007-08-17; US2007-0964950P Applic. Date: 2007-08-17; US2007-0965022P Applic. Date: 2007-08-17

Inventor: BANGALORE RAMESH (US)

A1 Published: 2009-02-19

Title: Perforated water soluble polymer based edible films

Application No.: US2008-0228703 Applic. Date: 2008-08-14

Abstract: A novel edible polymer based film dosage form manufactured using natural, synthetic, semisynthetic, pharmaceutically acceptable polymers addressing the issues of swallowing difficulties (Dysphagia and Dynaphagia), of tablet or capsule dosage forms and handling and storage difficulties associated with liquid dosage forms, that also includes materials such as emulsifying agents, suspending agents, buffering agents, effervescence agents, colorants, flavorants, sweetners and specified amounts of bioactive agents preferably having perforations in the body of the dosage form enabling it to disperse/dissolve rapidly upon application by the subject. A flexible film dosage form to accommodate higher drug loads without compromising the fast dispersing/dissolving characteristics is presented.; The perforated film system is enabled to be used in various applications such as oral, mucosal and external environments. The perforated film dosage form therefore, additionally allows the usage of polymers that would otherwise have not been used due to insolubility or limited solubility in water.

Priority: US2008-0228703 Applic. Date: 2008-08-14; US2007-0965043P Applic. Date: 2007-08-17; US2007-0965023P Applic. Date: 2007-08-17

Inventor: BANGALORE RAMESH (US)

A1 Published: 2009-02-19

Title: PHARMACEUTICAL COMPOSITION COMPRISING CURCUMIN AND RESVERATROL AND USES THEREOF IN MEDICAL FIELD

Applicant: SAFI INVEST HOLDING AG

Application No.: US2006-0067291 Applic. Date: 2006-02-21

Abstract: The present invention concerns a pharmaceutical composition containing curcumin and resveratrol and its application in the medical field. In particular, the composition according to the invention can be advantageously employed for preventing ageing and vascular diseases, for the treatment and the prophylaxis of cancers as prostate carcinoma, of skin diseases as psoriasis, and of the piliferous system as hair loss.

Priority: IT2005-FI00031 Applic. Date: 2005-02-21; WO2006-IT00093 Applic. Date: 2006-02-21

Inventor: TURINI DAMIANO (IT); COCCOLONI STEFAN (IT)

A1 Published: 2009-02-19

Title: METHOD AND APPARATUS FOR MANUFACTURING POROUS ARTICLES

Application No.: US2008-0189658 Applic. Date: 2008-08-11

Abstract: A method for producing porous materials which comprises directing a plasma stream containing particles of a base material in liquid or solid/liquid form onto a substrate under controlled conditions in which the particles spot weld to the substrate or to one another without full fusion, and establishing relative movement between the plasma stream and the substrate whereby the material is deposited as a porous structure of desired porosity and shape.

Priority: US2008-0189658 Applic. Date: 2008-08-11; US2007-0956374P Applic. Date: 2007-08-16

Inventor: WITHERS JAMES C (US); SHAPOVALOV VLADIMIR (US)

A1 Published: 2009-02-19

Title: COMPOSITION FOR TREATING SULFUR MUSTARD TOXICITY AND METHODS OF USING SAME

Applicant: UNIV MARYLAND (US); US GOVERNMENT (US)

Application No.: US2005-0720283 Applic. Date: 2005-12-02

Abstract: One embodiment of the present invention provides a composition, comprising, in amounts effective to treat sulfur mustard or half sulfur mustard induced toxicity or skin damage: an agent that inhibits alkylation of -SH and] NH protein groups; an agent that reduces -SS- to SH; a scavenger of reactive oxygen species; a substrate that maintains tissue reduction-oxidation status; an agent that protects against invading inflammatory cells and associated oxidative stress; an antagonist of prostaglandin synthesis; and an agent that induces tissue regeneration. Methods of using the composition are also provided.

Priority: US2005-0720283 Applic. Date: 2005-12-02; US2004-0632834P Applic. Date: 2004-12-03; WO2005-US43341 Applic. Date: 2005-12-02

Inventor: VARMA SHAMBHU D (US); PETRALI JOHN (US)

A1 Published: 2009-02-19

Title: EXTERNAL PREPARATION COMPOSITION

Applicant: LION CORP (JP)

Application No.: US2008-0257853 Applic. Date: 2008-10-24

Abstract: An external preparation composition used for preventing or treating symptoms or diseases related to dermatopathy caused by dryness, UV rays and aging such as wrinkles and sags of the skin, pigmentation of the skin, skin roughness and coarse texture and skin diseases such as psoriasis, lichen, ichthyosis, keratosis, Darier's disease, pustulosis, acne, eczema and atopic dermatitis. The external preparation composition comprises at least one of acyl glucosamine derivatives represented by the following Formula (I): wherein R1, R2, R3, R4 and R5 are defined; and X is any one of groups represented by the following Formulas (A) to (C): wherein Y, n and R6 are also defined.

Priority: US2008-0257853 Applic. Date: 2008-10-24; US2005-0522032 Applic. Date: 2005-01-21; WO2002-JP07549 Applic. Date: 2002-07-25

Inventor: KAMBAYASHI HIROAKI (JP); KONTA HIROSHI (JP)

A1 Published: 2009-02-19

Title: MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES

Applicant: BOEHRINGER INGELHEIM INT (DE)

Application No.: US2008-0118992 Applic. Date: 2008-05-12

Abstract: The present invention relates to the use of indolinones of general formula substituted in the 6 position, wherein R1, to R5 and X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, as a medicament for the prevention or treatment of specific fibrotic diseases.

Priority: US2008-0118992 Applic. Date: 2008-05-12; EP2004-0030768 Applic. Date: 2004-12-24; US2005-0275225 Applic. Date: 2005-12-20

Inventor: PARK JOHN EDWARD (DE); CHAUDHARY NVEED (GB); LEHMANN-LINTZ THORSTEN (DE); HECKEL ARMIN (DE); ROTH GERALD JUERGEN (DE); KLEY JOERG (DE); BRANDL TRIXI (CH); DAHMANN GEORG (DE); GRAUERT MATTHIAS (DE)

A1 Published: 2009-02-19

Title: BIOLOGICALLY ACTIVE OILS

Application No.: US2008-0125024 Applic. Date: 2008-05-21

Abstract: A process for the production of fats or oils and their extracts containing biologically active chemical compounds from a lipid substrate, the process comprising: a) inoculation of a lipid substrate with fungally derived lipolytic enzymes; b) incubating the inoculated substrate for a period of between about 7-120 days at a temperature of between about 435 DEG C., at a humidity of between about 75-100%, and c) processing said substrate mixture to obtain a biologically active fat or oil.

Priority: US2008-0125024 Applic. Date: 2008-05-21; AU2003-0902823 Applic. Date: 2003-06-04; US2005-0559599 Applic. Date: 2005-12-02; WO2004-AU00745 Applic. Date: 2004-06-04

Inventor: TURNER ATHOL GILLIES (AU)

A1 Published: 2009-02-19

Title: Health and Entertainment Device for Collecting, Converting, Displaying and Communicating Data

Application No.: US2007-0840357 Applic. Date: 2007-08-17

Abstract: A method for integrating and managing data is provided that includes interacting with an end user via a health and entertainment device, the device including: an accelerometer that is operable to track activity data by the user and a music module operable to play music for the user. The device further includes a memory and a processor operable to convert data from the accelerometer into one or more metrics based on data received from the memory.

Priority: US2007-0840357 Applic. Date: 2007-08-17

Inventor: JAMES TERRY L (US); JAMES GRANT K (US)

A1 Published: 2009-02-19

Title: PATCH

Application No.: US2006-0093913 Applic. Date: 2006-11-20

Abstract: The invention provides a patch device adapted for use in the transdermal administration to a patient of a composition including one or more pharmaceutically, cosmetically, pesticidally, prophylactically, and nutritionally active substance, the patch consisting of a layered construct adapted to be adhered to the skin of a patient and defining a cavity for receiving one or more disruptable containers of the composition or components of the composition to be administered between a proximal layer and a distal layer thereof, which proximal layer is adapted in use to be located in intimate contact with the skin of the patient and which distal layer is in use disposed on the outer side thereof, wherein the proximal layer is partially permeable to that composition,; so that in use the integrity of the one or more containers may be disrupted thereby causing the composition to be disposed in the cavity and permeate from there through the proximal layer to be absorbed through the skin into the body of the patient. The invention further provides a method of applying an irritant to the skin of a user.

Priority: GB2005-0024121 Applic. Date: 2005-11-26; WO2006-ZA00131 Applic. Date: 2006-11-20

Inventor: VAN ROOYEN QUINTON (NA); VAN ROOYEN CHRISTINA (NA); JONES JOHANNES (NA); LE ROUX ABRAHAM JOSUA (ZA); POWELL CORNELIUS JOHANNES (NA)

A1 Published: 2009-02-26

Title: APPARATUS AND METHOD FOR PHOTOGRAPHING IMAGE USING DIGITAL CAMERA CAPABLE OF PROVIDING PREVIEW IMAGES

Application No.: US2008-0197566 Applic. Date: 2008-08-25

Abstract: Disclosed is an apparatus for photographing an image using a digital camera capable of providing a preview image, including: an image sensor for capturing an image of a subject; a first image signal processor for processing at least one captured image as a sequent image in order to display the captured image as a preview image on a display window and detecting a face area from the captured image; a buffer for storing the image including at least one detected face area; a capture button for capturing a still image during outputting the sequent image as the preview image on the display window; a second image signal processor for processing the captured still image using the capture button; a controller for controlling to store the captured still image and information related on the face area detected from the first image signal processor prior to the input of the capture button; and a memory for storing the processed still image together with the information related on the detected face area.

Priority: KR2007-0085125 Applic. Date: 2007-08-23

Inventor: YOON JE-HAN (KR); KIM HYUN-SOO (KR); LEE JI-HYO (KR)

A1 Published: 2009-02-26

Title: TRANSDERMAL DRUG DELIVERY COMPOSITIONS AND TOPICAL COMPOSITIONS FOR APPLICATION ON THE SKIN

Application No.: US2007-0281768 Applic. Date: 2007-03-08

Abstract: Transdermal delivery compositions and topical compositions for application to the skin are provided. The transdermal delivery composition includes at least two penetrants working synergistically but by disparate biochemical pathways. In one embodiment, the transdermal delivery system includes benzyl alcohol and lecithin organogel. The transdermal delivery compositions are used in a variety of topical compositions as a means of transdermally delivering and topically administering different drugs and agents, including compositions promoting collagen biosynthesis, retinoids and skin lighteners, chemical denervation agents such as BOTOX(R), anti-fungal agents, anesthetics and non-steroidal anti-inflammatory drugs (NSAIDs).; In addition, these topical compositions may be used in combination with non-ablative treatment modalities, such as microdermabrasion, laser-based skin remodeling and radio-frequency-based skin remodeling.

Priority: US2007-0281768 Applic. Date: 2007-03-08; US2007-0878886P Applic. Date: 2007-01-03; US2006-0796007P Applic. Date: 2006-04-28; US2006-0781951P Applic. Date: 2006-03-08; US2006-0781950P Applic. Date: 2006-03-08; US2006-0781925P Applic. Date: 2006-03-08; US2006-0801349P Applic. Date: 2006-05-18; US2006-0781952P Applic. Date: 2006-03-08; WO2007-US06037 Applic. Date: 2007-03-08

Inventor: SAND BRUCE J (US); BABICH MICHAEL (US); HAGHIGHI ALI ZENDEDEL (US)

A1 Published: 2009-02-26

Title: SILICONE VESICLES CONTAINING ACTIVES

Application No.: US2007-0279352 Applic. Date: 2007-01-12

Abstract: A process is disclosed for preparing a hydrophobic active loaded vesicle composition by admixing a hydrophobic active to a pre-formed silicone vesicle dispersion. The silicone vesicle compositions are useful in a variety of personal and healthcare compositions.

Priority: US2007-0279352 Applic. Date: 2007-01-12; US2006-0777665P Applic. Date: 2006-02-28; WO2007-US00833 Applic. Date: 2007-01-12

Inventor: LIN SHAOW (US); THOMPSON JAMES (US)

A1 Published: 2009-02-26

Title: Peptides for Promoting Hair Growth and Improving Wrinkle and Cosmetic Compositions Comprising the same

Application No.: US2006-0083969 Applic. Date: 2006-10-24

Abstract: The present invention relates to a peptide comprising a specific amino acid sequence possessing human thymosin beta-4 (Tbeta4) activities and its uses. The peptide of this invention has identical or similar functions or actions to human Tbeta4 and its biological activity is almost identical to natural-occurring Tbeta4. In addition, the peptide of this invention exhibits much higher stability and skin permeation than natural-occurring Tbeta4. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on improvement in thymosin beta-4-effective disorders or conditions. In addition, the peptide of this invention can be advantageously applied to drugs, cosmetics, toothpaste and compositions for mouth cleaning and caring, most preferably, cosmetics.; Specifically, the peptide of this invention is advantageously applied to cosmetics for promoting hair growth.

Priority: KR2005-0100390 Applic. Date: 2005-10-24; WO2006-KR04352 Applic. Date: 2006-10-24

Inventor: CHUNG YONG JI (KR); KIM YOUNG DEUG (KR); KIM CHUNG RYUL (KR)

A1 Published: 2009-02-26

Title: Substituted gemini surfactant compounds

Applicant: UNIV SASKATCHEWAN (CA)

Application No.: US2008-0215963 Applic. Date: 2008-07-01

Abstract: The compositions, systems, and methods relate to substituted and asymmetric gemini surfactants for use in delivering biologically active agents, such as nucleic acids, to a subject. The described compositions, systems, and methods are useful for gene therapy.

Priority: US2008-0215963 Applic. Date: 2008-07-01; US2007-0958563P Applic. Date: 2007-07-06

Inventor: WETTIG SHAWN (CA); VERRALL RONALD ERNEST (CA); FOLDVARI MARIANNA (CA)

A1 Published: 2009-02-26

Title: BENZOFURAN DERIVATIVES WITH THERAPEUTIC ACTIVITIES

Applicant: PHARMOS CORP

Application No.: US2006-0915825 Applic. Date: 2006-05-31

Abstract: The present invention relates to novel benzofuran compounds, to pharmaceutical compositions that include such compounds, and to methods of use thereof. Certain compounds of the invention share some pharmacological properties with cannabinoids and have a common wide range of beneficial therapeutic indications. In particular, compounds of the invention are useful as analgesic, neuroprotective, immunomodulatory and anti-inflammatory agents.

Priority: US2006-0915825 Applic. Date: 2006-05-31; US2005-0685374P Applic. Date: 2005-05-31; WO2006-IL00641 Applic. Date: 2006-05-31

Inventor: YACOVAN AVIHAI (IL); GRYNSZPAN FLAVIO (IL); AIZIKOVICH ALEXANDER (IL); BRODY MARCUS STEPHEN (US); BAR-JOSEPH AVI (IL); MEILIN SIGAL (IL)

A1 Published: 2009-02-26

Title: COMPOSITIONS OF PHOSPHODIESTERASE TYPE IV INHIBITORS

Application No.: US2006-0090798 Applic. Date: 2006-10-19

Abstract: Provided herein are pharmaceutical compositions comprising one or more phosphodiesterase inhibitors of type IV ("PDE-IV"), and at least one other active ingredients selected from muscarinic receptor antagonists (MRA), beta2-agonists, p38 MAP Kinase inhibitors, and corticosteroids and optionally one or more pharmaceutically acceptable excipients and/or other therapeutic agents. In addition, methods of treating autoimmune, inflammatory or allergic diseases or disorders are provided.

Priority: IN2005-DE02793 Applic. Date: 2005-10-19; WO2006-IB02931 Applic. Date: 2006-10-19

Inventor: RAY ABHIJIT (IN); DASTIDAR SUNANDA G (IN); SHIRUMALLA RAJKUMAR (IN); GUPTA SUMAN (IN)

A1 Published: 2009-02-26

Title: MULTIPLE WAVELENGTH LASER WORKSTATION

Applicant: CYNOSURE INC

Application No.: US2008-0191163 Applic. Date: 2008-08-13

Abstract: Lasers capable of lasing at least two wavelengths are provided having a lasing medium which is capable of lasing at a first wavelength and at a second wavelength. An output coupler is positioned along a longitudinal axis at a first end of the lasing medium and a first mirror, movable beam block shutter and second mirror are positioned sequentially along the longitudinal axis of the lasing medium at a second end of the lasing medium. The first mirror is highly reflective at a first wavelength, and the second mirror is highly reflective at a second wavelength while being transparent at the first wavelength. The beam block shutter is movable between a first position along the longitudinal axis of the lasing medium and between the first and second mirrors and a second position away from the longitudinal axis of the lasing medium.; Also provided are laser workstations having two lasers driven by a single electronics drive system in which a single energy storage network is connected to a first laser pump chamber operative to excite a first laser medium and connected to a second laser pump chamber operative to excite a second laser medium. In certain embodiments, a switch connects the single energy storage network to a secondary winding of a high voltage trigger transformer, which is itself connected to the laser pump chambers. These high voltage trigger transformer serve to selectively ionize the excitation source in one of the laser pump chambers such that when the switch is closed, energy from the energy storage network will flow through the pump chamber whose excitation source(s) has been previously ionized.; In other embodiments, the single energy storage network is connected to the excitation sources via active semiconductor switches that permit the release of portions of energy stored in the single energy storage network to one of the lasers, leaving additional energy to be immediately or rapidly released to the excitation source of the first or another laser. Also provided are methods of treating skin having a skin problem using multiple wavelengths of laser energy.

Priority: US2008-0191163 Applic. Date: 2008-08-13; US2005-0035680 Applic. Date: 2005-01-14

Inventor: SIERRA RAFAEL ARMANDO (US); KOSCHMANN ERIC CALVIN (US); DAY JOSEPH M (US); SHERR EVAN ANDREW (US); BOLL JAMES HENRY (US)

A1 Published: 2009-03-05

Title: Personal care compositions comprising certain dye-polymer complexes

Application No.: US2008-0231579 Applic. Date: 2008-09-04

Abstract: The present invention relates to personal care compositions comprising certain dye-polymer complexes. Additionally, methods for coloration of personal care compositions using said dye-polymer complexes are disclosed.

Priority: US2008-0231579 Applic. Date: 2008-09-04; US2007-0967534P Applic. Date: 2007-09-05

Inventor: SONG ZHIQIANG (US); JAYNES BINGHAM SCOTT (US); LUPIA JOSEPH ANTHONY (US); ZHOU XIAN-ZHI (US)

A1 Published: 2009-03-05

Title: Compounds, Formulations and Methods for Reducing Skin Wrinkles, Creasing and Sagging

Application No.: US2008-0180790 Applic. Date: 2008-07-28

Abstract: Methods, compounds, and topical formulations for reduction of skin sagging, creasing and/or wrinkling are disclosed. The methods comprise topically applying a composition comprising an alpha2 adrenergic receptor agonist. Amelioration of skin sagging, creasing and/or wrinkling begins within minutes after topical application of a disclosed composition. A single application can significantly reduce skin sagging, creasing and/or wrinkling for at least about 8 hours.

Priority: US2008-0180790 Applic. Date: 2008-07-28; US2007-0952298P Applic. Date: 2007-07-27

Inventor: DEJOVIN JACK (US); DEJOVIN ISABELLE JEAN (US)

A1 Published: 2009-03-05

Title: Novel synthetic triterpenoids and methods of use in the treatment and prevention of multiple scleroris

Applicant: REATA PHARMACEUTICALS INC (US)

Application No.: US2008-0151425 Applic. Date: 2008-05-05

Abstract: The present invention overcomes limitations of the prior art by providing new compounds and methods for the treatment of conditions, such as neurodegenerative diseases (e.g., multiple sclerosis), psychiatric disorders (e.g., psychosis, bipolar disorder, depression, neuropathic pain), conditions involving CNS-mediated chronic pain, spinal cord injuries, and other diseases or injuries.

Priority: US2008-0151425 Applic. Date: 2008-05-05; US2007-0916273P Applic. Date: 2007-05-04

Inventor: SPORN MICHAEL B (US); LIBY KAREN T (US); GRIBBLE GORDON W (US); HONDA TADASHI (US); LETTERIO JOHN (US)

A1 Published: 2009-03-05

Title: Anti-IL-13 antibody formulations and uses thereof

Applicant: WYETH CORP (US)

Application No.: US2008-0008129 Applic. Date: 2008-01-09

Abstract: Formulations suitable for treatment of disorders associated with undesirable expression or activity of IL-13 are provided.

Priority: US2008-0008129 Applic. Date: 2008-01-09; US2007-0879500P Applic. Date: 2007-01-09

Inventor: BARRY ANTHONY B (US); CROWLEY THOMAS J (US); DIXON DANIEL A (US); SOLEY ERIN CHRISTINE (US)

A1 Published: 2009-03-05

Title: PROTEASES PRODUCING AN ALTERED IMMUNOGENIC RESPONSE AND METHODS OF MAKING AND USING THE SAME

Application No.: US2007-0933027 Applic. Date: 2007-10-31

Abstract: The present invention provides novel protein variants that exhibit reduced immunogenic responses, as compared to the parental proteins. The present invention further provides DNA molecules that encode novel variants, host cells comprising DNA encoding novel variants, as well as methods for making proteins less allergenic. In addition, the present invention provides various compositions that comprise these proteins that are less immunogenic than the wild-type proteins.

Priority: US2007-0933027 Applic. Date: 2007-10-31; US2004-0498714 Applic. Date: 2004-06-14

Inventor: ESTELL DAVID A (US); HARDING FIONA A (US)

A1 Published: 2009-03-05

Title: COSMETIC USE OF BIFIDOBACTERIUM SPECIES LYSATE FOR THE TREATMENT OF DRYNESS

Applicant: OREAL (FR)

Application No.: US2008-0200426 Applic. Date: 2008-08-28

Abstract: Cosmetic use of an effective amount of a lysate of at least one microorganism of the genus Bifidobacterium species and/or one of its fractions in treating and/or preventing dryness and/or associated disorders of a keratinous substance.

Priority: US2008-0200426 Applic. Date: 2008-08-28; FR2007-0057348 Applic. Date: 2007-09-04; US2007-0973541P Applic. Date: 2007-09-19

Inventor: CASTIEL ISABELLE (FR); BRETON LIONEL (FR); GUENICHE AUDREY (FR)

A1 Published: 2009-03-05

Title: CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS

Application No.: US2008-0202939 Applic. Date: 2008-09-02

Abstract: The present invention relates to biodegradable polymers (e.g., polyesters and polyester amides) derived from functionalized biologically active compounds that can provide site specific delivery of bioactive compounds upon biodegradation in a controlled manner.

Priority: US2008-0202939 Applic. Date: 2008-09-02; US2007-0968917P Applic. Date: 2007-08-30

Inventor: BEZWADA RAO S (US)

A1 Published: 2009-03-05

Title: COSMETIC MATERIAL CONTAINING SWEE PEA EXTRACT

Application No.: US2006-0910237 Applic. Date: 2006-03-14

Abstract: A cosmetic material, cell growth promoting agent, elastase activity inhibiting agent and anti-aging agent containing sweet pea extract, formulated with the aim of preventing or slowing aging.

Priority: JP2005-0106563 Applic. Date: 2005-04-01; WO2006-JP304966 Applic. Date: 2006-03-14

Inventor: HITOMI TAKAMASA (JP); MATSUKUMA SHOKO (JP)

A1 Published: 2009-03-05

Title: Therapeutic use of cpg oligodeoxynucleotide for skin disease

Application No.: US2005-0589102 Applic. Date: 2005-11-04

Abstract: Disclosed is the therapeutic use of CpG oligodeoxynucleotides for skin diseases. The CpG oligodeoxynucleotides (CpG ODNs) of the present invention show excellent immunoactive effects against skin diseases in both cases of CpG ODNs with a phosphorothioate backbone and CpG ODNs with a phosphodiester backbone.

Priority: WO2005-KR03717 Applic. Date: 2005-11-04; KR2004-0090000 Applic. Date: 2004-11-05

Inventor: KIM TAE-YOON (KR); KIM DOO-SIK (KR); KWON HYUNG-JOO (KR); KIM YANG-SOON (KR)

A1 Published: 2009-03-05

Title: PHARMACEUTICAL COMPOSITION

Application No.: US2007-0849652 Applic. Date: 2007-09-04

Abstract: Topical composition for enhanced local and systemic delivery of poorly soluble biologically active compounds, comprises of non-volatile solvent or mixture of solvents to dissolve active component, and moisture absorbent or mixture of sorbents to prevent precipitation or crystallization of insoluble material after application

Priority: US2007-0849652 Applic. Date: 2007-09-04

Inventor: SCHWARZ JOSEPH (US); WEISSPAPIR MICHAEL (US)

A1 Published: 2009-03-05

Title: ORAL PREPARATION FOR PROMOTING SYNTHESIS OF TISSUE COLLAGEN

Applicant: KYOWA HAKKO KOGYO KK (JP)

Application No.: US2007-0280846 Applic. Date: 2007-03-23

Abstract: An object of the present invention is to provide an oral preparation for promoting synthesis of tissue collagen, an oral preparation for promoting healing of skin wounds or an oral preparation for preventing or improving skin wrinkles or sagging, which is safe and has an excellent effect. The present invention can provide an oral preparation for promoting synthesis of tissue collagen, an oral preparation for promoting healing of skin wounds or an oral preparation for preventing or improving skin wrinkles or sagging, which comprises hydroxyproline or a salt thereof as an active ingredient.

Priority: JP2006-0079921 Applic. Date: 2006-03-23; WO2007-JP55977 Applic. Date: 2007-03-23

Inventor: KAMIYA TOSHIKAZU (JP); KAMIMURA AYAKO (JP); KAWADA YOKO (JP)

A1 Published: 2009-03-05

Title: DECALINE-DERIVED COMPOUNDS AS PHARMACEUTICALLY ACTIVE AGENTS

Applicant: UNI DORTMUND (DE); MAX PLANCK GES ZUR FODERUNG DE (DE); UNI BERN (DE)

Application No.: US2005-0813129 Applic. Date: 2005-12-28

Abstract: The present invention relates to compounds having a decaline scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said decaline-derived compounds can be used for prophylaxsis and/or treatment of diabetes mellitus type I, diabetes mellitus type II, tuberculosis and other infectious diseases, proliferative diseases, cancer, neurodegenerative diseases, obesity, cognitive dysfunctions and metabolic syndromes.

Priority: EP2004-0031076 Applic. Date: 2004-12-31; WO2005-EP14100 Applic. Date: 2005-12-28

Inventor: ODERMATT ALEX (CH); WALDMANN HERBERT (DE); SCHECK MICHAEL (DE); KOCH MARCUS A (DE)

A1 Published: 2009-03-05

Title: ACTIVE SUBSTANCE COMBINATION OF LICOCHALCONE A AND PHENOXYETHANOL

Applicant: BEIERSDORF AG (DE)

Application No.: US2008-0270009 Applic. Date: 2008-11-13

Abstract: A method for the prophylaxis or treatment of inflammatory skin conditions, which method comprises applying to the skin a cosmetic or pharmaceutical preparation comprising licochalcone A and phenoxyethanol. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.

Priority: US2008-0270009 Applic. Date: 2008-11-13; DE2003-1056164 Applic. Date: 2003-12-02; US2004-0001224 Applic. Date: 2004-12-02

Inventor: KRUSE INGE (DE); RASCHKE THOMAS (DE); VIETZKE JENS-PETER (DE); ECKERT JULIA (DE)

A1 Published: 2009-03-12

Title: WET WIPES DISPENSING SYSTEM

Applicant: KIMBERLY CLARK CO (US)

Application No.: US2008-0267007 Applic. Date: 2008-11-07

Abstract: The present disclosure relates to wet wipe dispensing systems for dispensing wet wipes capable of changing temperature upon use. In one embodiment, the dispensing system includes a wet wipe container and a lotion container that is held in assembly with the wet wipe container that contains a lotion that is kept separate from the wet wipes until the wet wipe is dispensed from the wet wipe container. The lotion includes a microencapsulated delivery vehicle that contains a temperature change agent that is capable of generating a temperature change upon contact with an aqueous solution. Once the wet wipe is dispensed from the system, an applicating device can apply the lotion to the wet wipe to facilitate contact between the temperature change agent in the microencapsulated delivery vehicle and the aqueous solution of the wet wipe.

Priority: US2008-0267007 Applic. Date: 2008-11-07; US2006-0420993 Applic. Date: 2006-05-30

Inventor: AMUNDSON JOHN DAVID (US); ABUTO FRANK P (US); CLARE TIMOTHY P (US); FOLEY EDWARD JOHN (US); WINDER ERIC MICHAEL (US); SCHMIDT PAUL R (US); JOSEPH WAEL R (US); MCDONALD DUANE LYLE (US)

A1 Published: 2009-03-12

Title: Sprayable Depilatory Composition and a Method of use

Application No.: US2006-0083329 Applic. Date: 2006-10-16

Abstract: A sprayable depilatory composition including a depilatory agent; a surfactant present in the range 0.1% to 5.0% by weight of the composition, wherein the composition has an initial viscosity substantially less than about 7.00 Pas.

Priority: GB2005-0020930 Applic. Date: 2005-10-14; WO2006-GB03821 Applic. Date: 2006-10-16

Inventor: CAWTHORNE LEE (GB)

A1 Published: 2009-03-12

Title: USE OF A LYSATE OF BIFIDOBACTERIUM SPECIES FOR TREATING SENSITIVE SKIN

Applicant: OREAL (FR)

Application No.: US2008-0200417 Applic. Date: 2008-08-28

Abstract: Cosmetic use of an effective amount of at least one lysate of at least one microorganism of the genus Bifidobacterium species and/or a fraction thereof, for preventing and/or treating a skin disorder in the case of sensitive skin.

Priority: US2008-0200417 Applic. Date: 2008-08-28; FR2007-0057352 Applic. Date: 2007-09-04; US2007-0973534P Applic. Date: 2007-09-19

Inventor: CASTIEL ISABELLE (FR); BRETON LIONEL (FR); GUENICHE AUDREY (FR)

A1 Published: 2009-03-12

Title: USE OF FREE RADICAL SCAVENGERS FOR PROTECTING AND TREATING SKIN AND HAIR DAMAGES CAUSED BY CHEMOTHERAPY

Application No.: US2006-0913501 Applic. Date: 2006-05-04

Abstract: The present invention relates to the use of one or more free radical scavengers as prophylactically or therapeutically effective substances and microparticles having an average particle size ranging from 5 to 200 mum for the preparation of a topical pharmaceutical composition for the protection or treatment of skin or hair damages caused by chemotherapeutic treatment. The invention also concerns a method for the protection or treatment of skin and hair damages of a mammal caused by chemotherapy. The invention further relates to a kit for the protection or treatment of hair damages caused by chemotherapeutic treatment consisting of a topical composition comprising microparticles together with free radical scavengers and a shampoo for an effective hair cleaning and supporting the hair treatment.; A kit for the protection or treatment of skin damages caused by chemotherapy consisting of a topical composition comprising microparticles together with free radical scavengers and a cleansing milk for an effective skin cleaning and supporting the skin treatment is a further object of the present invention.

Priority: DE2005-10021804 Applic. Date: 2005-05-04; DE2005-10023497 Applic. Date: 2005-05-18; WO2006-EP62076 Applic. Date: 2006-05-04

Inventor: GOLZ-BERNER KARIN (MC); ZASTROW LEONHARD (MC)

A1 Published: 2009-03-12

Title: INVERT EMULSIONS CONTAINING DHEA

Applicant: GALDERMA RES & DEV (FR)

Application No.: US2008-0168356 Applic. Date: 2008-07-07

Abstract: Stable, recrystallization-resistant invert emulsions, suited, e.g., for preventing/treating the signs of chronological or actinic skin aging and for preventing/treating atrophy of the skin or mucous membranes, comprise a cosmetically/therapeutically effective amount of DHEA and/or chemical and/or biological precursor or derivative thereof, such invert emulsions also comprising a glycolic or hydroglycolic dispersed hydrophilic phase, a lipophilic continuous phase and an emulsifier having an HLB ranging from 2 to 7.

Priority: US2008-0168356 Applic. Date: 2008-07-07; FR2001-0010398 Applic. Date: 2001-08-02; US2004-0767814 Applic. Date: 2004-01-30; WO2002-FR02569 Applic. Date: 2002-07-18

Inventor: ASTRUC FANNY (FR); ORSONI SANDRINE (FR); FREDON LAURENT (FR); SIMONNET JEAN-THIERRY (FR); RICHART PASCAL (FR)

A1 Published: 2009-03-12

Title: Novel therapeutic compounds

Application No.: US2008-0218364 Applic. Date: 2008-07-15

Abstract: Disclosed herein are novel compounds of Formula (I), wherein the variables are defined as herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases as well as proliferative disorders such as cancer.

Priority: US2008-0218364 Applic. Date: 2008-07-15; US2007-0959631P Applic. Date: 2007-07-16

Inventor: BREINLINGER ERIC C (US); CUSACK KEVIN P (US); HOBSON ADRIAN D (US); LI BIN (US); GORDON THOMAS D (US); STOFFEL ROBERT H (US); WALLACE GRIER A (US); GRONGSAARD PINTIPA (US); WANG LU (US)

A1 Published: 2009-03-12

Title: PHARMACEUTICAL COMPOSITIONS OF 5-ALPHA-REDUCTASE INHIBITORS AND METHODS OF USE THEREOF

Application No.: US2008-0268301 Applic. Date: 2008-11-10

Abstract: Non-occlusive compositions for transdermal delivery of 5-alpha-reductase inhibitors, and more particularly finasteride or dutasteride or pharmaceutically acceptable salts or derivatives thereof, and methods of making same. The composition may, for example, be a gel suitable for transdermal or transmucosal applications. The compositions of the present invention typically include a mixture of water and alcohol, and a solvent system having a mono alkyl ether of diethylene glycol and a glycol present in specified ratios and in specific amounts, wherein the pH of the gel is usually between about pH 4.5 and about pH 8. The compositions may include further components, for example, the hydroalcoholic vehicle may further include additional penetration enhancer(s), buffering agent(s), antioxidant(s), stabilizer(s) and/or gelling agent(s).; Also, a method for the sustained delivery of 5-alpha-reductase inhibitors to treat a variety of conditions and disorders.

Priority: US2008-0268301 Applic. Date: 2008-11-10; US2007-0755923 Applic. Date: 2007-05-31; US2006-0371042 Applic. Date: 2006-03-07; WO2004-EP11175 Applic. Date: 2004-10-06; US2003-0510613P Applic. Date: 2003-10-10

Inventor: CARRARA DARIO NORBERTO R (CH); GRENIER ARNAUD (FR)

A1 Published: 2009-03-12

Title: Use of pargyline for the treatment of hair folliclies

Applicant: CUTECH S R I

Application No.: US2008-0231385 Applic. Date: 2008-09-02

Abstract: Use of Pargyline for the production of a medicament for influencing the metabolism of hair follicles and the modulation of their vital cycle.

Priority: EP2007-0017594 Applic. Date: 2007-09-07

Inventor: PERTILE PAOLO (IT)

A1 Published: 2009-03-12

Title: HYDROPHOBICALLY MODIFIED POLYMERS

Application No.: US2007-0853084 Applic. Date: 2007-09-11

Abstract: This invention pertains to composition comprising one or more hydrophobically modified polyacrylamides, wherein the polyacrylamides contain acrylamide, one or more anionic monomers, and excludes a cationic monomer, and a method of using the composition for consumer and/or industrial applications.

Priority: US2007-0853084 Applic. Date: 2007-09-11

Inventor: HESSEFORT YIN Z (US); MAREK PATRICK J (US); CRAMM JEFFREY R (US); PATEL DAMYANTI J (US); CARLSON WAYNE M (US)

A1 Published: 2009-03-12

Title: Analyte Monitoring Device and Methods of Use

Applicant: ABBOTT DIABETES CARE INC (US)

Application No.: US2008-0210122 Applic. Date: 2008-09-12

Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor.; The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

Priority: US2008-0210122 Applic. Date: 2008-09-12; US2003-0420057 Applic. Date: 2003-04-18; US2000-0667199 Applic. Date: 2000-09-21; US1998-0070677 Applic. Date: 1998-04-30

Inventor: SAY JAMES (US); TOMASCO MICHAEL F (US); HELLER ADAM (US); GAL YORAM (IL); ARIA BEHRAD (US); HELLER EPHRAIM (US); PLANTE PHILLIP JOHN (US); VREEKE MARK S (US); FRIEDMAN KEITH A (US); COLMAN FREDRIC C (US)

A1 Published: 2009-03-19

Title: INDAZOLES AS GLUCOCORTICOID RECEPTOR LIGANDS

Applicant: GLAXO GROUP LTD (GB)

Application No.: US2006-0910935 Applic. Date: 2006-04-12

Abstract: A compound of formula (I): wherein A1 represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl; X represents -C(R3)- or nitrogen; when X represents -C(R3)-, R2 represents hydrogen and R1 represents fluorine, R3 represents hydrogen or fluorine, when X represents -C(R3)- and R2 and R1 each represent hydrogen, R3 represents hydrogen, hydroxy, methoxy or fluorine, when X represents -C(R3)- and R2 represents hydroxy, methoxy, -CO2CH3 or -CO2CH2CH3, R1 and R3 each represent hydrogen, when X represents nitrogen, R1 and R2 each represent hydrogen; and Y represents H or methyl; or a physiologically functional derivative thereof.

Priority: GB2005-0007597 Applic. Date: 2005-04-14; GB2005-0016375 Applic. Date: 2005-08-09; GB2005-0022882 Applic. Date: 2005-11-09; WO2006-EP03551 Applic. Date: 2006-04-12

Inventor: ELDRED COLIN DAVID (GB); HOUSE DAVID (GB); INGLIS GRAHAM GEORGE ADAM (GB); MACDONALD SIMON JOHN FAWCETT (GB); SKONE PHILIP ALAN (GB)

A1 Published: 2009-03-19

Title: Neuroactive steroid compositions and methods of use therefor

Applicant: UNIV DUKE (US)

Application No.: US2008-0008259 Applic. Date: 2008-01-08

Abstract: Provided are methods for ameliorating a symptom of a neuropsychiatric disorder in a subject. Also provided are methods for ameliorating at least one physical symptom or at least one psychological symptom resulting from tobacco cessation in a subject, methods for ameliorating a symptom of Alzheimer's disease or other cognitive disorder in a subject, methods for ameliorating a symptom of schizophrenia, schizoaffective disorder, or other psychotic disorder in a subject, methods for ameliorating a symptom of a depressive disorder in a subject, methods for ameliorating a symptom of bipolar disorder in a subject, methods for ameliorating a symptom of post-traumatic stress disorder or other anxiety disorder in a subject, methods for predicting a predisposition to suicide, suicidal ideation, suicidal behavior, or a combination thereof in a subject,; methods for ameliorating a symptom of a pain disorder in a subject, methods for ameliorating a neurodegenerative disorder in a subject, methods for ameliorating a symptom of traumatic brain injury in a subject, methods for ameliorating a sleep disorder in a subject, and methods for improving cognitive functioning in a subject. In some embodiments, the methods include administering to a subject in need thereof an effective amount of a neuroactive steroid composition comprising pregnenolone (PG), allopregnanolone (ALLO), dehydroepiandrosterone (DHEA), pharmaceutically acceptable salts thereof, derivatives thereof, or combinations thereof.

Priority: US2008-0008259 Applic. Date: 2008-01-08; US2007-0879165P Applic. Date: 2007-01-08

Inventor: MARX CHRISTINE E (US); ROSE JED E (US)

A1 Published: 2009-03-19
Patent No.: US7618644B2 Issued: 2009-11-17

Title: Stabilized body care products, household products, textiles and fabrics

Applicant: CIBA SC HOLDING AG (US)

Application No.: US2008-0291742 Applic. Date: 2008-11-13

Abstract: Disclosed are stabilized body care products, household products, textiles and fabrics which comprise certain dialkylhydroxyamine stabilizers, dialkylhydroxylamine stabilizer salts, nitrone stabilizers or amine oxide stabilizers. Dyed products and articles are effectively stabilized against color degradation. The products are for example skin-care products, hair-care products, dentifrices, cosmetics, laundry detergents and fabric softeners, non-detergent based fabric care products, household cleaners and textile-care products.

Priority: US2008-0291742 Applic. Date: 2008-11-13; US2007-0901423 Applic. Date: 2007-09-17; US2004-0970112 Applic. Date: 2004-10-21; US2003-0515889P Applic. Date: 2003-10-30

Inventor: LUPIA JOSEPH A (CH); SUHADOLNIK JOSEPH (US); WOOD MARVIN G (US); WOOD MERVIN G (US)

A1 Published: 2009-03-19

Title: SILANE ESTERS AND AMIDES OF 2-OXOTHIAZOLIDINE-4-CARBOXYLIC ACID, AND COSMETIC USES THEREOF

Applicant: OREAL (FR)

Application No.: US2005-0577600 Applic. Date: 2005-09-27

Abstract: The present invention relates to novel compounds of formula (1) and also to cosmetic compositions containing them and to the cosmetic uses thereof, in particular for protecting the skin against UV-induced oxidative stress.

Priority: US2005-0577600 Applic. Date: 2005-09-27; FR2004-0052399 Applic. Date: 2004-10-21; US2004-0632541P Applic. Date: 2004-12-03; WO2005-EP12032 Applic. Date: 2005-09-27

Inventor: LUCET-LEVANNIER KARINE (FR)

A1 Published: 2009-03-19

Title: PLATELET-DERIVED GROWTH FACTOR COMPOSITIONS AND METHODS OF USE THEREOF

Application No.: US2008-0323183 Applic. Date: 2008-11-25

Abstract: A method for promoting growth of bone, periodontium, ligament, or cartilage in a mammal by applying to the bone, periodontium, ligament, or cartilage a composition comprising platelet-derived growth factor at a concentration in the range of about 0.1 mg/mL to about 1.0 mg/mL in a pharmaceutically acceptable liquid carrier and a pharmaceutically-acceptable solid carrier.

Priority: US2008-0323183 Applic. Date: 2008-11-25; US2005-0159533 Applic. Date: 2005-06-23; US2004-0965319 Applic. Date: 2004-10-14

Inventor: LYNCH SAMUEL E (US)

A1 Published: 2009-03-19

Title: AMINOARYLVINYL-S-TRIAZINE COMPOUNDS AND USES THEREOF

Applicant: OREAL (FR)

Application No.: US2008-0277784 Applic. Date: 2008-11-25

Abstract: The invention relates to the use of at least one agent for screening out light radiation with a wavelength ranging from 370 to 500 nm as an agent for inhibiting the degradation of endogenous carotenoids present in the skin. The invention is useful for treating skin disorders caused by sunlight (e.g., solar urticaria, actinic dermatitis and pigmentation marks). The invention also relates to novel aminoaryl-vinyl-s-triazine compounds and to the use thereof as agents for screening out light radiation ranging from 370 to 500 nm.

Priority: US2008-0277784 Applic. Date: 2008-11-25; FR2003-0006800 Applic. Date: 2003-06-05; US2004-0859404 Applic. Date: 2004-06-03; US2003-0508312P Applic. Date: 2003-10-06

Inventor: CANDAU DIDIER (FR); DURANTON ALBERT (FR); PRUCHE FRANCIS (FR); RICHARD HERVE (FR)

A1 Published: 2009-03-19

Title: TRANSDERMAL ACTIVE PRINCIPLE DELIVERY MEANS

Applicant: HENDERSON MORLEY PLC (GB)

Application No.: US2006-0065591 Applic. Date: 2006-08-22

Abstract: A transdermal active principle delivery means comprises a skin adherent or otherwise skin-tolerant substrate applicable to a skin area affected by DNA virus, which substrate includes a composition for treating DNA comprising a transdermally effective carrier medium including at least one active principle selected from the group consisting of diuretic agents and/or cardiac glycoside agents.

Priority: GB2005-0017838 Applic. Date: 2005-09-02; WO2006-GB03143 Applic. Date: 2006-08-22

Inventor: PARDOE IAN STUART (GB); HARTLEY CHRISTOPHER (GB)

A1 Published: 2009-03-19

Title: Nanoparticulate compositions having lysozyme as a surface stabilizer

Applicant: ELAN PHARMA INT LTD

Application No.: US2008-0292091 Applic. Date: 2008-11-12

Abstract: The present invention is directed to nanoparticulate active agent compositions comprising lysozyme as a surface stabilizer. Also encompassed by the invention are pharmaceutical compositions comprising a nanoparticulate active agent composition of the invention and methods of making and using such nanoparticulate and pharmaceutical compositions.

Priority: US2008-0292091 Applic. Date: 2008-11-12; US2003-0357514 Applic. Date: 2003-02-04; US2002-0353230P Applic. Date: 2002-02-04

Inventor: WERTZ CHRISTIAN F (US); RYDE NIELS P (US)

A1 Published: 2009-03-19

Title: Encapsulated Bleaching Agent Particles

Applicant: HENKEL AG & CO KGAA (DE)

Application No.: US2008-0273722 Applic. Date: 2008-11-19

Abstract: A shelf-stable liquid agent or detergent containing a bleaching agent in the form of a finely particulate bleaching agent encapsulated in a crosslinkable polymer matrix.

Priority: DE2006-10023937 Applic. Date: 2006-05-19; WO2007-EP54528 Applic. Date: 2007-05-10

Inventor: SCHMIEDEL PETER (DE); VOELKEL HEINZ-JUERGEN (DE); KAISER HERIBERT (DE); VON RYBINSKI WOLFGANG (DE); HOELSKEN SOEREN (DE); BLANK VOLKER (DE); GUCKENBIEHL BERNHARD (DE)

A1 Published: 2009-03-19

Title: COMPOSITION COMPRISING AT LEAST ONE C-GLYCOSIDE DERIVATIVE AND AT LEAST ONE HYALURONIC ACID AND ITS COSMETIC USE

Applicant: OREAL (FR)

Application No.: US2008-0192698 Applic. Date: 2008-08-15

Abstract: The present invention relates to a topical cosmetic and/or dermatological composition comprising, in a physiologically acceptable medium, at least one hyaluronic acid or a derivative thereof and at least one C-glycoside derivative.

Priority: US2008-0192698 Applic. Date: 2008-08-15; WO2007-FR51579 Applic. Date: 2007-07-02; US2007-0968892P Applic. Date: 2007-08-30; US2006-0817683P Applic. Date: 2006-07-03; US2007-0894254P Applic. Date: 2007-03-12

Inventor: BISSEY LAURE (FR); LABOUREAU JULIEN (FR); SENEE JEROME (FR); SAUSSAY SOPHIE (FR)

A1 Published: 2009-03-19

Title: Thieno-and furo-pyrimidine modulators of the histamine H4 receptor

Application No.: US2008-0283700 Applic. Date: 2008-09-12

Abstract: Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.

Priority: US2008-0283700 Applic. Date: 2008-09-12; US2007-0972589P Applic. Date: 2007-09-14

Inventor: EDWARDS JAMES P (US); NEFF DANIELLE K (US); SMITH DEBORAH M (US); VENABLE JENNIFER D (US)

A1 Published: 2009-03-19

Title: CONTROL RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS FROM MULTI-ARMED OLIGOMERS

Applicant: BEZWADA BIOMEDICAL LLC (US)

Application No.: US2008-0203761 Applic. Date: 2008-09-03

Abstract: The present invention relates to the discovery of biodegradable multi-armed oligomers wherein the end groups of these oligomers have been functionalized with biologically active molecules. The resultant multi-armed oligomers end-functionalized with biologically active molecules have a controllable degradation profile. The hydrolytic degradation of oligomers of the present invention releases the biologically active compound as such with no change in native chemical structure.

Priority: US2008-0203761 Applic. Date: 2008-09-03; US2007-0969787P Applic. Date: 2007-09-04

Inventor: BEZWADA RAO S (US)

A1 Published: 2009-03-19

Title: DEVICE FOR TREATMENT OF BARRIER MEMBRANES

Application No.: US2008-0272198 Applic. Date: 2008-11-17

Abstract: The present invention features a device having a barrier membrane contacting surface, the device containing: a power source; a first conductive electrode; a second conductive electrode; and a carrier; wherein the power source is in electric communication with the first conductive electrode and the second conductive electrode, wherein the first conductive electrode and the second conductive electrode are in ionic communication with the carrier, and wherein the carrier is in communication with the barrier membrane contacting surface.

Priority: US2008-0272198 Applic. Date: 2008-11-17; US2003-0609727 Applic. Date: 2003-06-30

Inventor: SUN YING (US); LIU JUE-CHEN (US); WU JEFFREY M (US); HAUSCHILD JAMES E (US)

A1 Published: 2009-03-26

Title: Crosslinked Polytetrahydrofuran-Containing Polyurethanes

Applicant: BASF AG (DE)

Application No.: US2005-0658268 Applic. Date: 2005-07-22

Abstract: The invention relates to a cross-linked polyurethane, which contains, in an integrated manner, at least one polytetrahydrofuran and one polyisocyanate mixture, to cosmetic or pharmaceutical agents containing a polyurethane of the aforementioned type, and to the use of these polyurethanes.

Priority: DE2004-10036146 Applic. Date: 2004-07-26; WO2005-EP08040 Applic. Date: 2005-07-22

Inventor: NGUYEN KIM SON (DE); KAISER THOMAS (DE); HAUCK RALF (DE)

A1 Published: 2009-03-26

Title: Water-based delivery systems

Application No.: US2008-0082406 Applic. Date: 2008-04-09

Abstract: The invention relates to a water-based delivery system for an active substance, characterized by enhancing skin barrier restoration in the stratum corneum comprising water, a fatty acid, cholesterol, a ceramide and at least one skin lipid precursor.

Priority: US2008-0082406 Applic. Date: 2008-04-09; US2003-0388371 Applic. Date: 2003-03-13; US2002-0365059P Applic. Date: 2002-03-13

Inventor: SKOLD THOMAS (SE)

A1 Published: 2009-03-26

Title: TOPICAL USE OF THIAZOLIDINE DERIVATIVES AGAINST CONSEQUENCES OF OXIDATIVE STRESS OF SKIN

Applicant: EXSYMOL SA (MC)

Application No.: US2008-0233661 Applic. Date: 2008-09-19

Abstract: A cosmetic composition intended for protecting skin against stress generating free radicals or reactive oxygen species is disclosed. The cosmetic composition comprises a physiologically compatible excipient and a thiazolidine compound. Methods of protecting skin generally and against cutaneous consequences of oxidative stress are also disclosed.

Priority: FR2007-0006641 Applic. Date: 2007-09-21

Inventor: SEGUIN MARIE CHRISTINE (MC)

A1 Published: 2009-03-26

Title: Extracts From Black Yeast For Whitening Skin

Application No.: US2007-0860909 Applic. Date: 2007-09-25

Abstract: The present invention relates to topical skin whitening compositions comprising a whitening effective amount of a black yeast-derived melanin-degrading enzyme extract and a method of preparing the compositions. The compositions provide a whitening effect by degrading melanin on the surface of the skin, the hair and the nails. The enzyme extract can be derived from Exophiala mansonii. The compositions containing the enzyme extract are more effective than are similar compositions containing kojic acid in producing a whitening effect on the skin.

Priority: US2007-0860909 Applic. Date: 2007-09-25

Inventor: MAMMONE THOMAS (US); MUIZZUDDIN NEELAM (US); SCHNITTGER STEVEN F (US)

A1 Published: 2009-03-26

Title: Olefin wax, silicone-modified olefin wax, silicone-modified room temperature-solidifying composition using the wax, and cosmetics using them

Applicant: MITSUI CHEMICALS INC (JP); SHINETSU CHEMICAL CO (JP)

Application No.: US2008-0292724 Applic. Date: 2008-11-25

Abstract: An olefin wax (A) is (i) a copolymer (A1) obtained by copolymerizing ethylene and at least one diene or a copolymer (A2) obtained by copolymerizing ethylene, at least one olefin selected from alpha-olefins of 3 to 12 carbon atoms and at least one diene; wherein (ii) the content of unsaturated groups per one molecule is in the range of 0.5 to 3.0 groups; (iii) the density is in the range of 870 to 980 kg/m3; (iv) the melting point is in the range of 70 to 130 DEG C.; (v) the number-average molecular weight is in the range of 400 to 5,000; and (vi) the ratio (Mw/Mn) of the weight-average molecular weight to the number-average molecular weight is not more than 4.0. A silicone-modified olefin wax can be obtained by reacting hydrogen silicone with the olefin wax (A). Cosmetics contain the silicone-modified olefin wax.

Priority: US2008-0292724 Applic. Date: 2008-11-25; JP2002-0302202 Applic. Date: 2002-10-16; US2005-0531377 Applic. Date: 2005-09-26; WO2003-JP13265 Applic. Date: 2003-10-16

Inventor: TOYODA HIDEO (JP); UOSAKI HIROTAKA (JP); KAN KOUJIRO (JP); ICHINOHE SHOJI (JP); SHIMIZU TORU (JP)

A1 Published: 2009-03-26

Title: Use of Inhibitors of Indoleamine-2,3-Dioxygenase in Combination with Other Therapeutic Modalities

Applicant: MED COLLEGE GEORGIA RES INST (US)

Application No.: US2008-0175538 Applic. Date: 2008-07-18

Abstract: The present invention provides improved treatment methods by the administration of both an inhibitor of indoleamine-2,3-dioxygenase in addition to the administration of an additional therapeutic agent.

Priority: US2008-0175538 Applic. Date: 2008-07-18; US2004-0780797 Applic. Date: 2004-02-17; US2003-0459489P Applic. Date: 2003-04-01; US2004-0538647P Applic. Date: 2004-01-22

Inventor: MUNN DAVID (US); MELLOR ANDREW (US)

A1 Published: 2009-03-26

Title: METAL OXIDE COATING OF WATER INSOLUBLE INGREDIENTS

Applicant: SOL GEL TECHNOLOGIES LTD (IL)

Application No.: US2006-0997823 Applic. Date: 2006-08-02

Abstract: The invention relates to process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid water-insoluble particulate matter with a cationic additive in an aqueous medium to obtain a dispersion of said particulate matter having a positive zeta potential; (b) coating the solid water-insoluble particulate matter by precipitation of a metal oxide salt onto the surface of the particulate matter, forming a metal oxide layer thereon; and (c) aging said coating layer The invention further relates to coated particulate matter obtained by the process and to compositions comprising solid, water-insoluble particulate matter, coated by a metal oxide layer, the particulate matter being a dermatological active agent or a pesticide.; The invention additionally relates to methods of treating a surface condition in a subject using compositions comprising solid, water insoluble dermatologically active agent, coated by a metal oxide layer.

Priority: US2006-0997823 Applic. Date: 2006-08-02; US2005-0704455P Applic. Date: 2005-08-02; WO2006-IL00892 Applic. Date: 2006-08-02

Inventor: TOLEDANO OFER (IL); SERTCHOOK HANAN (IL); LOBODA NATALIA (IL); BAR-SIMANTOV HIAM (IL)

A1 Published: 2009-03-26

Title: MAST CELL-DERIVED RENIN

Applicant: CORNELL RES FOUNDATION INC (US)

Application No.: US2008-0237176 Applic. Date: 2008-09-24

Abstract: The invention relates to the discovery that renin is present in mast cells and can act in a localized manner to initiate and/or exacerbate a number of conditions. Thus, the invention provides methods for treating cardiac, vascular, lung, liver, cervical, intestinal, muscle, pancreatic, brain, kidney, skin and other conditions that involve inhibiting the synthesis and/or release of renin from mast cells and/or inhibiting the activity of renin after release from mast cells. The methods of the invention can also involve inhibiting elements of the local renin-angiotensin system (e.g. inhibiting ACE and angiotensin II receptors), thereby inhibiting angiotensin II produced locally from mast-cell-derived renin

Priority: US2008-0237176 Applic. Date: 2008-09-24; US2007-0657343 Applic. Date: 2007-01-24; US2004-0964567 Applic. Date: 2004-10-13; US2003-0512142P Applic. Date: 2003-10-17

Inventor: SILVER RANDI B (US); LEVI ROBERTO (US)

A1 Published: 2009-03-26

Title: USE OF RADICAL-CAPTURING SUBSTANCES IN A TOPICAL PREPARATION FOR ANTIPYRETIC TREATMENT

Application No.: US2006-0913488 Applic. Date: 2006-05-04

Abstract: The present invention relates to the use of one or more radical-capturing substances as therapeutically active substances in a topical preparation for antipyretic treatment. The invention is also directed to the use of radical-capturing substances as active agents in a combined preparation for the treatment of fever, said combined preparation comprising a topical preparation and an oral preparation in free combination, and the two preparations independently including one or more free-radical-capturing substances. According to the invention, the two preparations of the combined preparation are intended for simultaneous, separate or time-differentiated administration.

Priority: DE2005-10021806 Applic. Date: 2005-05-04; WO2006-EP62075 Applic. Date: 2006-05-04

Inventor: GOLZ-BERNER KARIN (MC); ZASTROW LEONHARD (MC)

A1 Published: 2009-03-26

Title: Compositions and Methods for Enhancing In-Vivo Uptake of Pharmaceutical Agents

Applicant: DO COOP TECHNOLOGIES LTD

Application No.: US2007-0087428 Applic. Date: 2007-01-04

Abstract: Pharmaceutical compositions comprising liquid, nanostructures and pharmaceutical agents are provided. Methods of use such compositions are also provided.

Priority: US2007-0087428 Applic. Date: 2007-01-04; IL2001-0147049 Applic. Date: 2001-12-12; US2006-0324586 Applic. Date: 2006-01-04; WO2005-IL00198 Applic. Date: 2005-02-17; US2004-0865955 Applic. Date: 2004-06-14; WO2002-IL01004 Applic. Date: 2002-12-12; US2006-0755852P Applic. Date: 2006-01-04; US2006-0755850P Applic. Date: 2006-01-04; US2006-0755851P Applic. Date: 2006-01-04; US2004-0545955P Applic. Date: 2004-02-20; WO2007-IL00014 Applic. Date: 2007-01-04

Inventor: GABBAI ERAN (IL)

A1 Published: 2009-03-26

Title: Boron nitride-containing silicone gel composition

Applicant: MOMENTIVE PERFORMANCE MAT INC

Application No.: US2007-0903109 Applic. Date: 2007-09-20

Abstract: A stable silicone oil composition is provided which comprises: a) at least one silicone gel; b) at least one boron nitride powder (a); c) a static charge-dissipating amount of at least one silicone oil; and, d) optionally, at least one component selected from the group consisting of other silicone, surfactant, emulsifier, solvent, emollient, moisturizer, humectant, pigment, colorant, fragrance, preservative, antioxidant, biocide, biostat, antiperspirant, exfoliant, hormone, enzyme, medicinal, vitamin substance, hydroxy acid, retinol, retinol derivative, niacinamide, skin lightening agent, salt, electrolyte, alcohol, polyol, ester, ultraviolet radiation scattering and/or absorbing agent, botanical extract, peptide, protein, organic oil, gum, saccharide, oligosaccharide, polysaccharide, derivative, wax, film former, thickening agent, particulate filler, plasticizer, humectant, occlusive,; sensory enhancer, resin and optically active particle.

Priority: US2007-0903109 Applic. Date: 2007-09-20

Inventor: WAHL ROY UWE ROJAS (US); DUFFY JANET LYNN (US)

A1 Published: 2009-03-26

Title: Method for producing langerhans cells or interstitial dendritic cells or both from CD14+ monocytes

Application No.: US2007-0897617 Applic. Date: 2007-09-01

Abstract: The present invention relates to a method for preparing Langerhans cells or interstitial dendritic cells, or both, from CD14+ monocytes stemming from the peripheral circulatory blood of a living being, wherein the method comprises differentiation of CD14+ monocytes into either Langerhans cells, interstitial dendritic cells, or into both types of cells by placing the CD14+ monocytes in the presence of a cell environment comprising epithelial cells and/or mesenchymatous cells. The present invention also relates to cell or tissue models comprising such prepared Langerhans cells and/or interstitial dendritic cells, and optionally macrophages and endothelial cells, and to the uses of such cell or tissue models.

Priority: US2007-0897617 Applic. Date: 2007-09-01

Inventor: BECHETOILLE NICOLAS (FR); ANDRE VALERIE (FR); ORLY ISABELLE (FR); PERRIER ERIC (FR)

A1 Published: 2009-03-26

Title: Muteins of Placental Growth Factor Type I, Preparation Method And Application Thereof

Application No.: US2007-0967469 Applic. Date: 2007-12-31

Abstract: The present invention relates to chemically stable muteins of type 1 Placental Growth Factor (PLGF-1) bearing the substitution or elimination of a cysteine residue from the wild type protein amino acid sequence, their preparation, their therapeutic and cosmetic uses, and pharmaceutical and cosmetic compositions containing said derivatives. The invention likewise relates to the production of antibodies for said derivatives and their use in the diagnosis and treatment of tumoral and non-tumoral pathologies.

Priority: US2007-0967469 Applic. Date: 2007-12-31; IT2002-RM00277 Applic. Date: 2002-05-17; US2005-0514707 Applic. Date: 2005-01-07; WO2003-IT00296 Applic. Date: 2003-05-19

Inventor: SALVIA GIUSEPPE (IT)

A1 Published: 2009-03-26

Title: METHODS OF ENHANCING MUCOSAL HYDRATION AND MUCOSAL CLEARANCE BY TREATMENT WITH SODIUM CHANNEL BLOCKERS AND OSMOLYTES

Applicant: PARION SCIENCES INC (US)

Application No.: US2007-0852003 Applic. Date: 2007-09-07

Abstract: The present invention relates to methods and compositions for treating diseases ameliorated by increased mucociliary clearance and mucosal hydration by administering an effective amount of a sodium channel blocker as defined herein and an osmolyte to a subject to a subject in need of increased mucociliary clearance and mucosal hydration.

Priority: US2007-0852003 Applic. Date: 2007-09-07; US2006-0842963P Applic. Date: 2006-09-08; US2006-0842669P Applic. Date: 2006-09-07

Inventor: JOHNSON MICHAEL ROSS (US); BOUCHER RICHARD C (US); HIRSH ANDREW J (US)

A1 Published: 2009-03-26

Title: Substituted phenylamino-benzene derivatives useful for treating hyper-proliferative disorders and diseases associated with mitogen extracellular kinase activity

Applicant: BAYER HEALTHCARE AG

Application No.: US2008-0151855 Applic. Date: 2008-05-09

Abstract: This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.

Priority: US2008-0151855 Applic. Date: 2008-05-09; EP2008-0075314 Applic. Date: 2008-04-22; US2007-0928789P Applic. Date: 2007-05-11

Inventor: LI YINGFU (US); RUDOLPH JOACHIM (US); DUMAS JACQUES P (US); AUCLAIR DANIEL (US); LOBELL MARIO (DE); HITCHCOCK MARION (DE); HARTUNG INGO (DE); KOPPITZ MARCUS (DE); BRITTAIN DOMINIC (DE); PUEHLER FLORIAN (DE); PETERSEN KIRSTIN (DE); GUENTHER JUDITH (DE)

A1 Published: 2009-03-26

Title: N-SUBSTITUTED PIPERIDINE DERIVATIVES AS SEROTONIN RECEPTOR AGENTS

Applicant: ACADIA PHARM INC (US)

Application No.: US2008-0234582 Applic. Date: 2008-09-19

Abstract: Disclosed herein are isolated forms of the compounds of Formula (I), (II), (III), (IV) and (V), or a pharmaceutically acceptable salt, prodrug, hydrate, solvate, polymorph, or ester thereof. Also disclosed are methods of inhibiting an activity of a serotonin receptor, methods inhibiting an activation of a serotonin receptor, and methods of alleviating or treating various disease conditions and side effects.

Priority: US2008-0234582 Applic. Date: 2008-09-19; US2007-0974426P Applic. Date: 2007-09-21; US2008-0050976P Applic. Date: 2008-05-06

Inventor: ULDAM HENRIETTE KOLD (DK); THYGESEN MIKKEL BOAS (DK)

A1 Published: 2009-04-02

Title: Use of pyrimidine derivatives for cosmetic purposes

Application No.: US2006-0921656 Applic. Date: 2006-06-12

Abstract: The present invention is directed to the use of certain pyrimidine derivatives for cosmetic purposes, i.e. for the preparation of a composition for providing a cosmetic effect. It was found that said pyrimidine derivatives are particularly useful for treating wrinkles but also for thickening the epidermis, for improving hair growth and for treating grey hair. The present invention is also directed to a composition containing said pyrimidine derivatives. In particular, said composition is a cosmetic preparation.

Priority: WO2006-EP05609 Applic. Date: 2006-06-12; EP2005-0013111 Applic. Date: 2005-06-17; EP2006-0754298 Applic. Date: 2006-06-12

Inventor: TREMBLEY MARCELLA (DE); VOLLHARDT JUERGEN H (CH)

A1 Published: 2009-04-02

Title: ALGINATE-BASED NANOFIBERS AND RELATED SCAFFOLDS

Applicant: WASHINGTON UNIVERSITY OF (US)

Application No.: US2008-0239478 Applic. Date: 2008-09-26

Abstract: Alginate nanofibers, scaffolds that include alginate nanofibers, implantable devices that include alginate nanofibers, and methods for making the alginate nanofibers by electrospinning.

Priority: US2008-0239478 Applic. Date: 2008-09-26; WO2007-US65388 Applic. Date: 2007-03-28; US2006-0787099P Applic. Date: 2006-03-28

Inventor: ZHANG MIQIN (US); BHATTARAI NARAYAN (US)

A1 Published: 2009-04-02

Title: DEPILATORY PRODUCT

Application No.: US2008-0111314 Applic. Date: 2008-04-29

Abstract: The invention comprises a depilatory product based on a complexing gel. The product will remove the hair via reduction and hydrolysis as do chemical depilatories. Despite the peeling nature of the product, the hair is not removed by pulling it out like a wax depilatory. The product is to be applied as a single step from a component that allows the mixing of two separate parts during application to the skin. The final gel is plastic and pliable but non-mobile similar to silicone rubber. The gel should possess strength so that it can be removed from the skin as a single piece without breaking or ripping.

Priority: US2008-0111314 Applic. Date: 2008-04-29; US2007-0997005P Applic. Date: 2007-09-28

Inventor: OTT JR DAVID S (US)

A1 Published: 2009-04-02

Title: MULTIPLEX ASSAY METHOD FOR MIXED CELL POPULATIONS

Applicant: GOVERNMENT OF THE USA AS REPRE

Application No.: US2008-0060752 Applic. Date: 2008-04-01

Abstract: Disclosed is an in vitro assay for evaluating cellular activity, in which a culture is provided that contains one or more histologically different isolated mammalian cell-line that stably and constitutively express fluorescent proteins having a different emission spectra. The culture is assessed for cellular activity by quantifying fluorescence or detecting a pattern of fluorescence from fluorescent proteins present in the culture. In some embodiments, the cellular activity of the cell-lines is assessed by determining one or more of the growth rate, migration potential, or tubule formation potential of the cell-lines using the quantified fluorescence or pattern of fluorescence. Also disclosed are cell-lines have been stably transfected with mammalian expression plasmids that constitutively express different fluorescent proteins.; Kits for performing the disclosed assays, which include the disclosed fluorescent cell-lines, are also disclosed.

Priority: US2008-0060752 Applic. Date: 2008-04-01; US2007-0976732P Applic. Date: 2007-10-01

Inventor: ZUDAIRE ENRIQUE (US); CUTTITTA FRANK (US)

A1 Published: 2009-04-02

Title: COMPOSITIONS COMPRISING THEM AS PPAR MODULATORS

Applicant: IRM LLC (BM)

Application No.: US2007-0160307 Applic. Date: 2007-01-25

Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.

Priority: US2007-0160307 Applic. Date: 2007-01-25; US2006-0763539P Applic. Date: 2006-01-30; WO2007-US02316 Applic. Date: 2007-01-25

Inventor: EPPLE ROBERT (US); RUSSO ROSS (US); AZIMIOARA MIHAI (US)

A1 Published: 2009-04-02

Title: N-(Pyridin-4-Yl)-2-Phenylbutanamides as Androgen Receptor Modulators

Application No.: US2006-0989412 Applic. Date: 2006-07-28

Abstract: Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies,; cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Priority: US2006-0989412 Applic. Date: 2006-07-28; US2005-0704702P Applic. Date: 2005-08-02; WO2006-US29457 Applic. Date: 2006-07-28

Inventor: MEISSNER ROBERT S (US); PERKINS JAMES J (US); KIM YUNTAE (US); HANNEY BARBARA (US); MCVEAN CAROL A (US)

A1 Published: 2009-04-09

Title: Body-care and household products and compositions comprising specific sulfur-containing compounds

Application No.: US2008-0229815 Applic. Date: 2008-08-27

Abstract: Disclosed are stabilized body care products, household products, textiles and fabrics which comprise specific sulfur containing compounds. Dyed products and articles are effectively stabilized against color degradation. The products are for example skin-care products, hair-care products, dentifrices, cosmetics, laundry detergents and fabric softeners, non-detergent based fabric care products, household cleaners and textile-care products.

Priority: US2008-0229815 Applic. Date: 2008-08-27; US2007-0998162P Applic. Date: 2007-10-09

Inventor: LUPIA JOSEPH A (US); REICH OLIVER (DE)

A1 Published: 2009-04-09

Title: Skin and/or Hair Products, Containing Compounds With an Isoprenoid Structure

Applicant: BEIERSDORF AG (DE)

Application No.: US2006-0587577 Applic. Date: 2006-12-08

Abstract: A composition of matter that is suitable for use on skin or hair. The composition comprises one or more compounds of formula wherein Rx, Ry, R3 and R5 are as defined in the specification, and at least one other component or element.

Priority: DE2004-10020714 Applic. Date: 2004-04-26; WO2005-EP51528 Applic. Date: 2005-04-06

Inventor: WOLBER RAINER (DE); KRUSE INGE (DE); SCHLENZ KATHRIN (DE); SCHERNER CATHRIN (DE); TOM DIECK KAREN (DE)

A1 Published: 2009-04-09

Title: Music and Accelerometer Combination Device for Collecting, Converting, Displaying and Communicating Data

Application No.: US2007-0866520 Applic. Date: 2007-10-03

Abstract: A method for integrating and managing data is provided that includes interacting with an end user via a music and health component combination device, the device including: a health component that is operable to track data by the user and a music module operable to play music for the user. The device further includes a memory and a processor operable to convert data from the health component into one or more metrics based on data received from the memory. In other embodiments, the device can display a category of music, such as an album or a play list. The device also includes a dimming function that allows certain parameters being displayed by the device to be highlighted, emphasized, or deemphasized.

Priority: US2007-0866520 Applic. Date: 2007-10-03

Inventor: JAMES TERRY L (US); JAMES GRANT K (US)

A1 Published: 2009-04-09

Title: Fragranced Therapeutic Delivery System

Application No.: US2006-0086911 Applic. Date: 2006-12-20

Abstract: The present invention relates to multi-functional topical delivery systems for providing long-lasting delivery of fragrance as. well as skin-supporting and/or pharmaceutically active ingredients comprising (i) an oil phase; (ii) an aqueous phase; (iii) phenoxyethanol at a concentration of from about 2.0% to about 2.7% based on the total weight of the composition; (iv) an effective exfoliating amount of a hydrophobic hydroxycarboxylic acid selected from the group consisting of orthohydroxybenzoic acid, hydroxycarboxylic acids containing a C12-C24 fatty acid esterified to the alpha carbon hydroxyl group, hydroxycarboxylic acids containing a C12-C24 fatty alcohol esterified to a carboxyl group; (v) a non-ionic emulsifier having an HLB of from about 7 to about 10; (vi) a fragrance composition; and (vii) at least one skin-supporting or dermatopharmaceutically active agent.

Priority: US2006-0086911 Applic. Date: 2006-12-20; US2005-0751635P Applic. Date: 2005-12-20; WO2006-US48383 Applic. Date: 2006-12-20

Inventor: MURAD HOWARD (US)

A1 Published: 2009-04-09

Title: THIAZOLYL-DIHYDRO-INDAZOLE

Application No.: US2008-0277543 Applic. Date: 2008-11-25

Abstract: The present invention relates to new thiazolyl-dihydro-indazoles of general formula (I) wherein the groups R1, R2 and R3 have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers and the mixtures thereof, and optionally the pharmacologically acceptable acid addition salts, solvates and hydrates thereof, and processes for preparing these thiazolyl-dihydro-indazoles and the use thereof as pharmaceutical compositions.

Priority: US2008-0277543 Applic. Date: 2008-11-25; EP2006-0112297 Applic. Date: 2006-04-06; US2007-0690351 Applic. Date: 2007-03-23

Inventor: GRAUERT MATTHIAS (DE); MAIER UDO (DE); HOFFMANN MATTHIAS (DE); SCHEUERER STEFAN (DE); JOERGENSEN ANNE T (DE); PAUTSCH ALEXANDER (DE); BRANDL TRIXI (CH); HOENKE CHRISTOPH (DE); BREITFELDER STEFFEN (DE); ERB KLAUS (DE); PIEPER MICHAEL (DE); PRAGST INGO (DE)

A1 Published: 2009-04-09

Title: Methods and Compositions for the Treatment of Pruritus

Application No.: US2008-0247618 Applic. Date: 2008-10-08

Abstract: The present invention is based on the discovery that a nalmefene salt or a peripherally acting analogue of nalmefene is capable of providing long-acting activity against pruritus, when applied topically. In addition, treatment with a nalmefene salt or peripherally acting analogue of nalmefene, can provide disease-modifying effects against the chronic symptoms of atopic dermatitis, including reductions of inflammatory cell infiltrate into the skin, epidermal hyperplasia and trans-epidermal water loss. Compositions of the invention have an inhibitory effect on the itch-scratch-cycle, leading to both relief of pruritus and disease-modifying activity.

Priority: GB2007-0019613 Applic. Date: 2007-10-08; GB2008-0009319 Applic. Date: 2008-05-22

Inventor: NAZIR TAHIR (GB); BAXTER ANDREW DOUGLAS (GB); ROTHAUL ALAN (GB)

A1 Published: 2009-04-09

Title: PHARMACEUTICAL COMPOSITION COMPRISING THIACREMONONE FOR PREVENTING OR TREATING CANCER

Applicant: NAT UNIV CHUNGBUK IND ACAD (KR)

Application No.: US2008-0186534 Applic. Date: 2008-08-06

Abstract: The present invention relates to an anti-cancer composition, which comprises a sulfur-containing compound thiacremonone as an active ingredient. The active ingredient induces the death of cancer cells by apoptosis through the action of specific inhibition of the activity of NF-kappaB. The composition can be effectively used in the treatment or prevention of cancer.

Priority: KR2007-0100998 Applic. Date: 2007-10-08

Inventor: HONG JIN TAE (KR); BAN JUNG OK (KR); JEONG HEON-SANG (KR); KIM DAE JOONG (KR)

A1 Published: 2009-04-16

Title: COMPOSITION AND METHODS FOR THE TREATMENT OF SKIN DISORDERS

Application No.: US2008-0242243 Applic. Date: 2008-09-30

Abstract: Methods and pharmaceutical compositions for use in the treatment of benign or malignant proliferative pathologies are disclosed. The methods involve the topical administration of nicotinamide or a nicotinamide derivative in combination with a vitamin D compound. The combination is shown to act in synergy and is especially useful for treatment of psoriasis and other skin disorders.

Priority: US2008-0242243 Applic. Date: 2008-09-30; IL2000-0133976 Applic. Date: 2000-01-11; US2002-0192842 Applic. Date: 2002-07-11; WO2001-IL00017 Applic. Date: 2001-01-09; US2008-0914093 Applic. Date: 2008-06-10; WO2006-IL00552 Applic. Date: 2006-05-10; US2008-0914102 Applic. Date: 2008-06-10; WO2006-IL00553 Applic. Date: 2006-05-10; US2005-0679329P Applic. Date: 2005-05-10; US2005-0679556P Applic. Date: 2005-05-10

Inventor: HAREL AVIKAM (IL); BLOCH OLGA (IL)

A1 Published: 2009-04-16

Title: Method For the Production of a Keratin-Binding Effector Molecule

Applicant: BASF SE (DE)

Application No.: US2006-0094833 Applic. Date: 2006-11-15

Abstract: The invention relates to a method of producing keratin-binding effector molecules, and to intermediates and end-products of the method according to the invention and to the use of the keratin-binding effector molecules produced according to the invention in dermocosmetics. In addition, the invention relates to a method of applying dermocosmetically active ingredients to skin and/or hair and to a method of increasing the residence time of an active ingredient on skin and hair.

Priority: EP2005-0111218 Applic. Date: 2005-11-24; EP2006-0116386 Applic. Date: 2006-06-30; WO2006-EP68470 Applic. Date: 2006-11-15

Inventor: BARG HEIKO (DE); LIEBMANN BURGHARD (DE); VOLKERT MARTIN (DE); PTOCK ARNE (DE); REENTS HEIKE (DE)

A1 Published: 2009-04-16

Title: AGENT FOR CORRECTING STRESS-INDUCING NEURO-MEDIATOR, NEURO-ENDOCRINE AND METABOLIC DISTURBANCES AND METHOD FOR PREVENTING AND TREATING CONCOMITANT PATHOLOGICAL CONDITIONS

Application No.: US2006-0066153 Applic. Date: 2006-08-23

Abstract: The invention relates to medicine, in particular to pharmacology, and is embodied in the form of an agent for limiting neuro-mediator, neuro-endocrine and metabolic disturbances generating the disorders of a central nervous system and functional somatic disorders. The inventive agent is based on a DSIP (delta sleep inducing peptide) or a derivative chemically related thereto and can be used for correcting and preventing functional shifts in a central nervous system and concomitant somatic disorders caused by unfavourable and extreme environmental factors and different pathological conditions of an organism or during the ageing thereof.; The inventive method for preventing and treating stress states with the aid of the inventive agent is characterised in that the inventive compositions can be administrated: intranasally in the form of intranasal drops or spray; sublingually in the form of resorbable tablets and capsules; in the form of powders, suppositories, ointments and creams; in the form of different injections (intracutaneous, hypodermic, intramuscular, and intravenous); in the form of different cosmetic agents (creams, lotions, tonics, cosmetic milk, foam, soap, etc.) and in the form of infant food components.

Priority: RU2005-0128993 Applic. Date: 2005-09-08; WO2006-RU00468 Applic. Date: 2006-08-23

Inventor: MIKHALEVA INESA IVANOVNA (RU); IVANOV VADIM TIKHONOVICH (RU); PRUDCHENKO IGOR ARKADJEVICH (RU); VOITENKOV BORIS OLEGOVICH (RU)

A1 Published: 2009-04-16

Title: Compositions and methods for the treatment of immune related diseases

Application No.: US2008-0153928 Applic. Date: 2008-05-28

Abstract: The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.

Priority: US2008-0153928 Applic. Date: 2008-05-28; US2003-0533519 Applic. Date: 2003-10-30; WO2003-US34312 Applic. Date: 2003-10-30; US2002-0423394P Applic. Date: 2002-11-01

Inventor: CLARK HILARY (US); SCHOENFELD JILL R (US); VANLOOKEREN MENNO (US); WILLIAMS P MICKEY (US); WOOD WILLIAM I (US); WU THOMAS D (US)

A1 Published: 2009-04-16

Title: Tetrahydropyridothiophenes as Antiproliferative Agents for the Treatment of Cancer

Applicant: ALTANA PHARMA AG (DE)

Application No.: US2006-0883624 Applic. Date: 2006-02-10

Abstract: Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.

Priority: EP2005-0101007 Applic. Date: 2005-02-11; EP2005-0104493 Applic. Date: 2005-05-25; EP2005-0112159 Applic. Date: 2005-12-14; WO2006-EP50859 Applic. Date: 2006-02-10

Inventor: PEKARI KLAUS (DE); SCHMIDT MATHIAS (DE); BAR THOMAS (DE); BECKERS THOMAS (NL); BARTELS BJORN (DE)

A1 Published: 2009-04-16

Title: Cosmetic composition in the form of an emulsion comprising a continuous aqueous phase and a dispersed fatty phase, and method for its preparation

Applicant: LVMH RECH (FR)

Application No.: US2008-0284861 Applic. Date: 2008-09-25

Abstract: The invention relates to a composition in the form of an emulsion comprising a continuous aqueous phase and a dispersed fatty phase, characterized in that said aqueous phase contains liposomes in the presence of a non-ionic surfactant chosen from fatty alcohol polyethylene glycol ethers and fatty alcohol polypropylene glycol ethers, and mixtures thereof, and of at least one polysaccharide in water-soluble form. It also relates to a method for preparing this composition. It also relates to a stable dispersion of liposomes that can be used for the preparation of the aqueous phase of this composition.

Priority: FR2007-0006749 Applic. Date: 2007-09-26

Inventor: ALARD VALERIE (FR); QUILES DOMINIQUE (FR); DUMAS MARC (FR); PERRIER ERIC (FR)

A1 Published: 2009-04-16

Title: TOPICAL PAIN RELIEF PRODUCT

Application No.: US2008-0249147 Applic. Date: 2008-10-10

Abstract: The present invention is directed to a topical composition comprising a counterirritant active ingredient and a sensate that provides a cooling sensation to the skin that is topically perceptible to an adult human subject for greater than about 90 minutes, e.g. greater than about 120 minutes, say greater than about 150 minutes, when applied in an effective amount over an area on the back of a hand, elbow, lower back or shoulder region. In one embodiment, the sensate can be encapsulated. The sensate can alternatively be bound to an ion exchange resin or adsorbed onto an adsorbant.

Priority: US2008-0249147 Applic. Date: 2008-10-10; US2007-0979222P Applic. Date: 2007-10-11

Inventor: ROBINSON RONNI L (US); WYNN DAVID W (US)

A1 Published: 2009-04-16

Title: TETRAHYDRO-PYRAZOLO-PYRIDINE THIOETHER MODULATORS OF CATHEPSIN S

Application No.: US2008-0031551 Applic. Date: 2008-02-14

Abstract: Tetrahydro-pyrazolo-pyridine thioether compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.

Priority: US2008-0031551 Applic. Date: 2008-02-14; US2007-0889976P Applic. Date: 2007-02-15

Inventor: AMERIKS MICHAEL K (US); ARIENTI KRISTEN L (US); EDWARDS JAMES P (US); GRICE CHERYL A (US); JONES TODD K (US); LEE-DUTRA ALICE (US); LIU JING (US); MANI NEELAKANDHA S (US); NEFF DANIELLE K (US); WICKBOLDT ALVAH T (US); WIENER JOHN J M (US)

A1 Published: 2009-04-16

Title: MULTI-FUNCTION ELECTRODE AND USES THEREOF

Application No.: US2007-0280078 Applic. Date: 2007-02-28

Abstract: The present invention is of an electrode comprising an electrode substrate base layer and a plurality of layers of insoluble pole electroactive substance disposed on the electrode substrate base layer, wherein each of the plurality of layers of insoluble pole electroactive substance is configured to facilitate a treatment of a condition. Further, the present invention is of use of the electrode in a currant generating treatment device.

Priority: US2007-0280078 Applic. Date: 2007-02-28; US2006-0776948P Applic. Date: 2006-02-28; WO2007-IL00265 Applic. Date: 2007-02-28

Inventor: NITZAN ZVI (IL); MOSHKOVICH MORDECHAY (IL); LEVY SHLOMO (IL)

A1 Published: 2009-04-23

Title: COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE THEREOF

Applicant: JERINI AG (DE)

Application No.: US2007-0162798 Applic. Date: 2007-01-31

Abstract: The present invention is related to a compound of formula (I), wherein A is a nonaromatic heterocyclic ring, Ar is either absent or phenylene; Psi is a radical of formula (II), R2 is a hydrophobic moiety; and G is a radical containing one or more moieties selected from the group consisting of NH, OH and a basic moiety. The compounds are inhibitors of integrins, especially antagonists of the fibronectin receptor alpha5beta1, useful as anti-angiogenic agents.

Priority: EP2006-0002005 Applic. Date: 2006-01-31; WO2007-EP00832 Applic. Date: 2007-01-31

Inventor: ZISCHINSKY GUNTER (DE); STRAGIES ROLAND (DE); OSTERKAMP FRANK (DE); SCHARN DIRK (DE); HUMMEL GERD (DE); KALKHOF HOLGER (DE); ZAHN GRIT (DE); VOSSMEYER DOERTE (DE); CHRISTNER-ALBRECHT CLAUDIA (DE); REINEKE ULRICH (DE)

A1 Published: 2009-04-23

Title: COMPOSITIONS COMPRISING ORGANIC AND INORGANIC PHOSPHORS FOR CONVERTING ELECTROMAGNETIC RADIATION AND METHODS FOR USING THE SAME

Application No.: US2008-0104047 Applic. Date: 2008-04-16

Abstract: There is disclosed a topical composition comprising at least one organic and/or inorganic phosphor in a physiologically acceptable medium, wherein the phosphor(s) is present in an amount effective to convert electromagnetic radiation of an initial frequency to a different frequency. In one embodiment, the phosphors convert the initial radiation frequency, such as infrared or visible light, to a higher frequency, such as ultraviolet (UV) radiation. In another embodiment, the phosphors convert the initial radiation from a higher frequency, such as UV radiation, to a lower frequency, such as infrared or visible light. Methods of treating keratinous material, such as the skin, hair, or lips, using the disclosed compositions are also disclosed.

Priority: US2008-0104047 Applic. Date: 2008-04-16; US2007-0911962P Applic. Date: 2007-04-16

Inventor: BERNSTEIN ERIC F (US); BELL HOWARD Y (US); BELOV VALERY (US)

A1 Published: 2009-04-23

Title: Topical anti-inflammatory compositions comprising O/W emulsions containing pro-penetrating glycols

Applicant: GALDERMA SA (CH)

Application No.: US2008-0232304 Applic. Date: 2008-09-15

Abstract: Topically applicable compositions in the form of oil-in-water (O/W) emulsions contain a pro-penetrating system including at least one glycol and at least one additional pro-penetrating agent, a suitable emulsifying system and at least one active agent of the family of steroidal anti-inflammatory agents, and are useful e.g., for the treatment of psoriasis.

Priority: FR2006-0002283 Applic. Date: 2006-03-15; WO2007-FR50925 Applic. Date: 2007-03-14

Inventor: SEGURA-ORSONI SANDRINE (FR); ROUMEC SOPHIE (FR)

A1 Published: 2009-04-23

Title: Topical anti-inflammatory compositions comprising O/W emulsions containing pro-penetrating glycols

Applicant: GALDERMA SA (CH)

Application No.: US2008-0232305 Applic. Date: 2008-09-15

Abstract: Topically applicable compositions in the form of oil-in-water emulsions contain a pro-penetrating system including at least one glycol and at least one additional pro-penetrating agent, a suitable gelling agent and at least one active agent of the family of steroidal anti-inflammatory agents and are useful, e.g., for the treatment of psoriasis.

Priority: FR2006-0002284 Applic. Date: 2006-03-15; WO2007-FR50927 Applic. Date: 2007-03-14

Inventor: SEGURA-ORSONI SANDRINE (FR); ROUMEC SOPHIE (FR)

A1 Published: 2009-04-23

Title: vWFA and/or ANT_IG Domain Containing Proteins

Applicant: ARES TRADING SA (CH)

Application No.: US2005-0718183 Applic. Date: 2005-10-28

Abstract: This invention relates to novel proteins (herein termed INSP141, INSP142, INSP143, and INSP144), herein identified as anthrax receptor-like proteins containing von Willebrand factor A (vWFA) and Anthrax receptor extracellular (ANT_IG) domains and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.

Priority: GB2004-0023974 Applic. Date: 2004-10-28; WO2005-GB04191 Applic. Date: 2005-10-28

Inventor: DAVIES MARK DOUGLAS (GB); MICHALOVICH DAVID (GB); YORKE MELANIE (CH); POWER CHRISTINE (FR)

A1 Published: 2009-04-23

Title: Controlled Release Hydrogels

Applicant: UNIV RUTGERS (US)

Application No.: US2005-0793566 Applic. Date: 2005-12-22

Abstract: Formulations and methods for their preparation including a hydrogel including a crosslinked matrix comprising a polymer, and a one or more liposomes containing a therapeutic agent.

Priority: US2005-0793566 Applic. Date: 2005-12-22; US2004-0638552P Applic. Date: 2004-12-22; WO2005-US46891 Applic. Date: 2005-12-22

Inventor: SINKO PATRICK J (US); STEIN STANLEY (US); LALLOO ANITA (US)

A1 Published: 2009-04-23

Title: Pharmaceutical and Dermatocosmetic Compositions Comprising Extract of Durio Zibenthinus

Application No.: US2006-0085907 Applic. Date: 2006-12-04

Abstract: The present invention relates to dermatocosmetic and pharmaceutical compositions comprising compounds obtained from Durio zibethinus and their use in increasing phase angle and reducing the signs and appearance of photoaging and biological aging.

Priority: US2006-0085907 Applic. Date: 2006-12-04; US2005-0741466P Applic. Date: 2005-12-02; WO2006-US46138 Applic. Date: 2006-12-04

Inventor: MURAD HOWARD (US)

A1 Published: 2009-04-23

Title: Molecules to Enhance Percutaneous Delivery and Methods for Discovery Therefor

Application No.: US2006-0883606 Applic. Date: 2006-01-17

Abstract: An IR spectroscopic technique provides methods for measuring the irritation potential of a formulation and to assess the ability of molecules to enhance the permeability of substances into and through skin using samples comprising stratum corneum. Molecules are screened for their performance as chemical penetration enhancers using a unique in silico procedure that may be applied iteratively in an attempt to generate molecules showing successively higher performance. Both the irritation potential and the ability of the molecule to enhance penetration are considered in the in silico approach. The invention provides specific molecules that may be used in topical or transdermal formulations to improve the delivery of actives. The structures of compounds of the invention include: Formulas (I), (II), (III), (IV), (V), (IV) and analogs thereof.

Priority: US2006-0883606 Applic. Date: 2006-01-17; US2005-0655839P Applic. Date: 2005-02-23; WO2006-US01964 Applic. Date: 2006-01-17

Inventor: MITRAGOTRI SAMIR (US); KARANDE PANKAJ (US); JAIN AMIT K (US)

A1 Published: 2009-04-30

Title: ANTIPRURITIC COSMETIC AND DERMATOLOGICAL PREPARATIONS

Applicant: BEIERSDORF AG (DE)

Application No.: US2008-0347241 Applic. Date: 2008-12-31

Abstract: A topical cosmetic or dermatological preparation which is effective for treating a pruritic condition, is present as a non-ionic O/W emulsion, and comprises water, one or more oil phases, PEG 12 cetearylether and/or PEG 40 monostearate, polidocanol, menthol, and one or more O/W emulsifiers or co-emulsifiers.

Priority: US2008-0347241 Applic. Date: 2008-12-31; DE2001-1058199 Applic. Date: 2001-11-27; US2002-0172241 Applic. Date: 2002-06-14

Inventor: ZELLE DAGMAR (DE); FILBRY ALEXANDER (DE); KROEPKE RAINER (DE)

A1 Published: 2009-04-30

Title: Photoprotective Composition and Screening Agents for Said Composition

Applicant: OREAL (FR)

Application No.: US2006-0988292 Applic. Date: 2006-07-12

Abstract: The present invention concerns a photoprotective composition comprising at least one interferential screening agent screening UVA and/or UVB.

Priority: US2006-0988292 Applic. Date: 2006-07-12; FR2005-0052211 Applic. Date: 2005-07-13; US2005-0708761P Applic. Date: 2005-08-17; WO2006-IB52361 Applic. Date: 2006-07-12

Inventor: CANDAU DIDIER (FR)

A1 Published: 2009-04-30

Title: COSMETIC COMPOSITION BASED ON A MAGNETIC OR MAGNETISABLE MATERIAL, THE PREPARATION THEREOF AND USE THEREOF FOR CLEANSING THE EPIDERMIS

Applicant: DERMOPHISIOLOGIQUE S R L (IT)

Application No.: US2008-0259724 Applic. Date: 2008-10-28

Abstract: The present invention relates to a cosmetic composition based on a magnetic or magnetisable material, the preparation thereof and use thereof for surface and deep cleansing of the epidermis. Said cosmetic composition has revealed to be particularly useful for preparing a mask for cleansing the epidermis of the face, breast, hands and body and, simultaneously, for maintaining the aesthetic appearance and functional efficiency thereof.

Priority: IT2007-MI02098 Applic. Date: 2007-10-30

Inventor: REDAELLI CAROLINA (IT)

A1 Published: 2009-04-30

Title: Loadable Polymeric Microparticles for Therapeutic Use in Alopecia and Methods of Preparing and Using the Same

Applicant: CELONOVA BIOSCIENCES INC (US)

Application No.: US2007-0928722 Applic. Date: 2007-10-30

Abstract: Particles are provided for use in restorative procedures to treat and/or retard alopecia The particles include poly[bis(trifluoroethoxy)phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in various colors or with customized coloration to match desired scalp colors. Moreover, such particles may be loaded to provide localized treatment with an active component agent directed at restoration of normal function and hair production within the hair follicle.

Priority: US2007-0928722 Applic. Date: 2007-10-30

Inventor: FRITZ OLAF (DE); FRITZ ULF (DE); WOJCIK RONALD (US); GASKINS JR RALPH E (US)

A1 Published: 2009-04-30

Title: QUATERNISED AMMONIUM CYCLODEXTRIN COMPOUNDS

Application No.: US2008-0238473 Applic. Date: 2008-09-26

Abstract: Use of a compound of formula (I): wherein the symbol represents a n-valent residue derived from a cyclodextrin compound by removing n of its hydroxyl groups; n is a number greater than 0 and represents the average number of substituents of formula per molecule of said compound; h is 0 or 1; R1 is a di-valent group selected from alkylene, hydroxy alkylene, halogeno alkylene, monocyclic aralkylene, cycloalkylene and phenylene; R2, R3 and R4 are each independently of one another a group selected from alkyl, cycloalkyl, aryl, aralkyl, and cycloheteryl; xm- is a m-fold negatively charged anion; m is an integer being equal or greater than 1; and k is n/m in the preparation of an anti-infective medicament, as preservative and penetration enhancer.

Priority: US2008-0238473 Applic. Date: 2008-09-26; EP2002-0013074 Applic. Date: 2002-06-13; EP2002-0028554 Applic. Date: 2002-12-20; US2004-0516247 Applic. Date: 2004-11-30; WO2003-EP06192 Applic. Date: 2003-06-12

Inventor: KIS GEORG LUDWIG (CH); SCHOCH CHRISTIAN (CH); SZEJTLI JOZSEF (HU)

A1 Published: 2009-04-30

Title: NOVEL TOPICAL APPLICATION AGENTS AGAINST MIMIC AND AGE-RELATED WRINKLES

Applicant: PENTAPHARM AG (CH)

Application No.: US2005-0718496 Applic. Date: 2005-11-01

Abstract: The compounds of formula (I) wherein X represents a bond or NH-CH(C-O)-(CH2)3+n-NH-R5, n represents 0, 1 or 2, R1, R4 and R5-independently from each other-represent hydrogen, possibly substituted C1-C6-alkyl, amidino or tetra-C1-C6-alkylamidinium, R2 represents hydrogen or possibly substituted C1-C6-alkyl or R1 and R2 together with the residue to which they are bound represent a 5- to 7-membered, saturated ring, R3 represents C1-C12-alkoxy, C1-C12-alkylamino, possibly substituted aryl-C1-C6-alkylamino, possibly substituted heteroaryl-C1-C6-alkylamino, possibly substituted aryl-C1-C6-alkoxy or possibly substituted heteroaryl-C1-C6-alkoxy, and R6 represents hydrogen or, when n is 1, also amino or together with R1 and the residue to which R6 and R1 are bound a 5- to 7-membered, saturated ring, as well as their physiologically acceptable salts are new.; They can be manufactured according to common methods and processed to topically applicable compositions that are appropriate for treating mimic and age-related wrinkles in human skin.

Priority: CH2004-0001809 Applic. Date: 2004-11-02; WO2005-CH00638 Applic. Date: 2005-11-01

Inventor: IMFELD DOMINIC (CH); ZIEGLER HUGO (CH); WIKSTROEM PETER (CH)

A1 Published: 2009-04-30

Title: FIBRONECTIN POLYPEPTIDES AND METHODS OF USE

Application No.: US2006-0089291 Applic. Date: 2006-10-04

Abstract: Described herein are fragments of fibronectin and variants thereof that bind growth factors. Compositions containing such a fragment of fibronectin are therefore useful in sequestering growth factors, and complexes containing both a FN fragment and a bound, active growth factor can be used to deliver growth factors to a patient (e.g., to a wound on the patient's skin).

Priority: US2006-0089291 Applic. Date: 2006-10-04; US2005-0723496P Applic. Date: 2005-10-04; WO2006-US38778 Applic. Date: 2006-10-04

Inventor: CLARK RICHARD A (US); REN XIANG-DONG (US); LIN FUBAO (US)

A1 Published: 2009-04-30

Title: COMPOSITIONS AND METHODS FOR TREATMENT OF EAR CANAL INFECTION AND INFLAMMATION

Applicant: EVERETT LAB INC

Application No.: US2007-0932191 Applic. Date: 2007-10-31

Abstract: The present invention relates to compositions and methods for treatment of ear infections and inflammation. Specifically, the method involves administering to a patient a composition containing an antibacterial, an anti-inflammatory, and an anti-septic that is substantially free of pramoxine to treat the occurrence or negative effects of otic infection and inflammation.

Priority: US2007-0932191 Applic. Date: 2007-10-31

Inventor: GIORDANO JOHN A (US)

A1 Published: 2009-04-30

Title: MEDICATION AGAINST BREAST CANCER AND RELATED DISEASES

Application No.: US2007-0300503 Applic. Date: 2007-05-11

Abstract: The present invention relates to novel uses of a steroid compound, which specifically binds to the androgen receptor (AR) but which is not metabolized by aromatase to a process for their preparation, to pharmaceutical compositions containing them, and to the use of said compounds for the prophylaxis and/or treatment of hormone-dependent or hormone receptor regulated cancers in mammals.

Priority: US2007-0300503 Applic. Date: 2007-05-11; EP2006-0009894 Applic. Date: 2006-05-12; US2006-0747124P Applic. Date: 2006-05-12; WO2007-EP04221 Applic. Date: 2007-05-11

Inventor: TEICHMANN ALEXANDER TOBIAS (DE)

A1 Published: 2009-04-30

Title: Aryl-substituted bridged or fused diamines as modulators of leukotriene A4 hydrolase

Application No.: US2008-0291018 Applic. Date: 2008-10-30

Abstract: Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A4 hydrolase (LTA4H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA4H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.

Priority: US2008-0291018 Applic. Date: 2008-10-30; US2007-0984126P Applic. Date: 2007-10-31

Inventor: BACANI GENESIS M (US); BEMBENEK SCOTT D (US); ECCLES WENDY (US); EDWARDS JAMES P (US); EPPERSON MATTHEW T (US); GOMEZ LAURENT (US); GRICE CHERYL A (US); KEARNEY AARON M (US); LANDRY-BAYLE ADRIENNE M (US); LEE-DUTRA ALICE (US); MCCLURE KELLY J (US); MIRZADEGAN TARANEH (US); SANTILLAN JR ALEJANDRO (US)

A1 Published: 2009-04-30

Title: Novel Compounds

Applicant: GLAXO WELLCOME HOUSE (GB)

Application No.: US2007-0226372 Applic. Date: 2007-04-18

Abstract: The present invention provides compounds of formula (I): pharmaceutical compositions comprising the compounds and the use of the compounds for the manufacture of a medicament, particularly for the treatment of inflammation and/or allergic conditions.

Priority: GB2006-0007840 Applic. Date: 2006-04-20; GB2006-0020382 Applic. Date: 2006-10-13; GB2007-0006515 Applic. Date: 2007-04-03; GB2007-0006516 Applic. Date: 2007-04-03; WO2007-EP53795 Applic. Date: 2007-04-18

Inventor: BIGGADIKE KEITH (GB); COOPER ANTHONY WILLIAM JAMES (GB); HOUSE DAVID (GB); MCLAY IAIN MCFARLANE (GB); WOOLLAM GRAHAME ROBERT (GB)

A1 Published: 2009-04-30

Title: METHOD AND APPARATUS FOR PROVIDING A MEDICAL DRESSING

Application No.: US2007-0931766 Applic. Date: 2007-10-31

Abstract: The invention relates to a medical dressing having an elastic material for encircling about a body member, an elastomer attached to the elastic material and adapted to directly contact a wound on the body member, and where the elastomer includes an additive for treating the wound, wherein the elastic material applies compressive force to the elastomer and wound as the elastic material encircles the body member.

Priority: US2007-0931766 Applic. Date: 2007-10-31

Inventor: DERR MICHAEL J (US)

A1 Published: 2009-05-07

Title: Cosmetic Process for the Treatment of the Skin with Sun-Protection Products and Sun-Protection Products Combination

Applicant: COTY BV (NL)

Application No.: US2005-0568092 Applic. Date: 2005-04-14

Abstract: The invention relates to a cosmetic method, whereby skin is treated with various sun products, and to a sun product combination. The inventive method is characterized by applying, prior to intensive exposure of the skin to UV radiation, a pre-sun product, then a sun product and finally repeatedly applying an after-sun product. The pre-sun product comprises a radical interceptor, the combination caffeine/complex amino acid salt, the combination photolyase/UV endonuclease and an algae extract of Corallina officinalis. The sun product comprises a UV filter combination of UVA and UVB filters having at least 3% by weight of UVA filter.; The after-sun product comprises components similar to those used for the pre-sun product, the content of the radical interceptor and the enzyme photolyase being by 50 to 90% by weight lower, the content of the enzyme UV endonuclease being by 50 to 90% by weight higher, and the algae extract being replaced by a cooling plant extract.

Priority: DE2004-10020060 Applic. Date: 2004-04-20; WO2005-EP04150 Applic. Date: 2005-04-14

Inventor: GOLZ-BERNER KARIN (MC); ZASTROW LEONHARD (MC)

A1 Published: 2009-05-07

Title: SKIN CARE PRODUCTS CONTAINING MULTIPLE ENHANCERS

Application No.: US2008-0243665 Applic. Date: 2008-10-01

Abstract: The present invention provides a skin care product comprising at least two enhancers and at least one skin care ingredient, wherein the at least two enhancers are selected from cyclodextrin, pentasodium pentetate, phytic acid, potassium citrate, sodium citrate, potassium gluconate and sodium gluconate.

Priority: US2008-0243665 Applic. Date: 2008-10-01; US2007-0976792P Applic. Date: 2007-10-01

Inventor: GROSS DENNIS F (US)

A1 Published: 2009-05-07

Title: COSMETIC COMPOSITIONS

Applicant: RECKITT & BENCKISER UK LTD (GB)

Application No.: US2006-0991676 Applic. Date: 2006-09-18

Abstract: The present invention relates to a solid cosmetic composition which includes a soap and/or a non-soap surfactant, a hair modification active and/or skin enhancing agent, and at least one silicone and/or mineral oil.

Priority: GB2005-0018934 Applic. Date: 2005-09-16; GB2006-0002109 Applic. Date: 2006-02-02; WO2006-GB03479 Applic. Date: 2006-09-18

Inventor: ELLIS PAUL (GB); HEESON TRACEY (GB); THOMAS MARK (US)

A1 Published: 2009-05-07

Title: Sulfonylpyrroles as Histone Deacetylase Inhibitors

Applicant: NYCOMED GMBH (DE)

Application No.: US2006-0887268 Applic. Date: 2006-04-07

Abstract: The invention relates to compounds of formula (I) which are effective inhibitors of histone deacetylases.

Priority: EP2005-0102750 Applic. Date: 2005-04-07; WO2006-EP03171 Applic. Date: 2006-04-07

Inventor: MAIER THOMAS (DE); BAR THOMAS (DE); BECKERS THOMAS (DE); ZIMMERMANN ASTRID (DE); DULLWEBER FRANK (DE); GEKELER VOLKER (DE)

A1 Published: 2009-05-07

Title: GRANULYSIN PEPTIDES AND METHODS OF USE THEREOF

Applicant: UNIV CALIFORNIA (US)

Application No.: US2006-0815650 Applic. Date: 2006-02-14

Abstract: Granulysin peptides are small antimicrobial agents with potent activity. A pharmaceutical composition comprising granulysin peptides as an active agent is administered therapeutically to a patient for exfoliation, e.g. for the treatment of skin lesions.

Priority: US2006-0815650 Applic. Date: 2006-02-14; US2005-0653232P Applic. Date: 2005-02-14; WO2006-US05306 Applic. Date: 2006-02-14

Inventor: KIM JENNY J (US)

A1 Published: 2009-05-07

Title: Transdermal sustained release drug delivery

Application No.: US2008-0288760 Applic. Date: 2008-10-23

Abstract: Provided herein are microprojections and microprojection arrays wherein a microprojection is coated with at least two layers. One layer comprises a biologically active agent, for example, a PTH agent and optionally other excipients. Another layer, which is generally, initially devoid of active agent comprises a polymer or a mix of polymers to provide controlled release, for example sustained release, of the biologically active agent contained in the first layer. Microprojections coated with multiple layers, some layers containing a biologically active agent and other layers containing a polymer for controlled release are also contemplated herein.

Priority: US2008-0288760 Applic. Date: 2008-10-23; US2007-0982127P Applic. Date: 2007-10-23

Inventor: AMERI MAHMOUD (US); MAA YUH-FUN (US)

A1 Published: 2009-05-07

Title: Disinfectant with Durable Activity Based on Alcohol-Soluble Quaternary Ammonium Polymers and Copolymers

Applicant: QUICK MED TECHNOLOGIES INC (US)

Application No.: US2009-0350784 Applic. Date: 2009-01-08

Abstract: An alcohol- or glycol-soluble, water-insoluble, disinfectant composition and a method of using the same for disinfecting and for providing a prolonged antimicrobial property to a variety of surfaces, including skin. The composition comprises at least one alcohol or glycol and an antimicrobial polymer that is capable of imparting an antimicrobial property to a surface without the use of a metal or a metal-containing compound. The composition is applied to a surface and allowed to evaporate leaving a coating of antimicrobial polymer. Alternatively, the composition is incorporated into or within the substrate.

Priority: US2009-0350784 Applic. Date: 2009-01-08; US2008-0064487 Applic. Date: 2008-02-22; WO2006-US32954 Applic. Date: 2006-08-22; US2008-0019798P Applic. Date: 2008-01-08; US2006-0806196P Applic. Date: 2006-06-29; US2005-0710128P Applic. Date: 2005-08-22

Inventor: TOREKI WILLIAM (US); OLDERMAN GERALD (US)

A1 Published: 2009-05-07

Title: MODIFIED SORBITAN SILOXANE COMPOSITIONS AND USE THEREOF

Applicant: KIMBERLY CLARK CO (US)

Application No.: US2007-0934567 Applic. Date: 2007-11-02

Abstract: The present disclosure generally relates to personal care compositions and wipes. More particularly, the disclosure relates to compositions and wipes for imparting a perceivable aesthetic feel to the skin of a user. To achieve the perceivable aesthetic feel, a modified sorbitan siloxane is incorporated into the compositions and wipes.

Priority: US2007-0934567 Applic. Date: 2007-11-02

Inventor: CUNNINGHAM COREY (US); WENZEL SCOTT W (US); LANGOLF BRIAN M (US); KIEFFER PHILIP E (US); DECKER CHRISTOPHER V (US)

A1 Published: 2009-05-07

Title: Conditioned Decellularized Native Tissues for Tissue Restoration

Application No.: US2009-0351757 Applic. Date: 2009-01-09

Abstract: The invention provides a composition conditioned for the remodeling, restoration, repair, or replacement of tissue within a host. The composition is conditioned by culturing cells on the matrix and/or by exposing the cultured cells or matrix to one or more stressors.

Priority: US2009-0351757 Applic. Date: 2009-01-09; US2004-0876299 Applic. Date: 2004-06-24; US2003-0482480P Applic. Date: 2003-06-25; US2004-0538385P Applic. Date: 2004-01-21

Inventor: BADYLAK STEPHEN F (US)

A1 Published: 2009-05-07

Title: Octahydropentalene compounds as chemokine receptor antagonists

Application No.: US2008-0284758 Applic. Date: 2008-09-25

Abstract: The present invention is directed to novel compounds of Formula (I) pharmaceutically acceptable salts thereof, pro-drugs thereof, biologically active metabolites thereof, isomers thereof or stereoisomers thereof wherein the variables are as defined herein. The compounds of Formula (I) are useful as chemokine receptor antagonists and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, rheumatoid arthritis, osteoarthritis, multiple sclerosis and asthma.

Priority: US2008-0284758 Applic. Date: 2008-09-25; US2007-0995148P Applic. Date: 2007-09-25

Inventor: GEORGE DAWN M (US); WANG LU (US); LI BIQIN (US); ERICSSON ANNA M (US); ANSELL GRAHAM K (US)

A1 Published: 2009-05-07

Title: MAPK/ERK KINASE INHIBITORS

Application No.: US2008-0050139 Applic. Date: 2008-03-17

Abstract: Compounds are provided for use with MEK that comprise: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Priority: US2008-0050139 Applic. Date: 2008-03-17; US2007-0895617P Applic. Date: 2007-03-19

Inventor: DONG QING (US); KANOUNL TOUFIKO (US); WALLACE MICHAEL B (US)

A1 Published: 2009-05-14

Title: ALPHAVBETA6 PEPTIDE LIGANDS AND THEIR USES

Application No.: US2006-0088998 Applic. Date: 2006-10-03

Abstract: AVbeta6 peptide ligands, functional variants thereof and their nucleic acids encoding them are disclosed with their uses in the treatment and imaging of AVbeta6 mediated diseases.

Priority: GB2005-0020068 Applic. Date: 2005-10-03; WO2006-GB03673 Applic. Date: 2006-10-03

Inventor: HOWARD MARK J (GB); DICARA DANIELLE (GB); MARSHALL JOHN F (GB)

A1 Published: 2009-05-14

Title: COMPOSITIONS FOR THE TREATMENT OF GASTROINTESTINAL INFLAMMATION

Applicant: MERITAGE PHARMA INC (US)

Application No.: US2008-0269832 Applic. Date: 2008-11-12

Abstract: Provided herein are methods for preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.

Priority: US2008-0269832 Applic. Date: 2008-11-12; US2008-0035348P Applic. Date: 2008-03-10; US2008-0054103P Applic. Date: 2008-05-16; US2008-0054105P Applic. Date: 2008-05-16; US2007-0012012P Applic. Date: 2007-12-06; US2008-0054107P Applic. Date: 2008-05-16; US2007-0015998P Applic. Date: 2007-12-21; US2008-0019818P Applic. Date: 2008-01-08; US2008-0034941P Applic. Date: 2008-03-07; US2008-0054106P Applic. Date: 2008-05-16; US2008-0090658P Applic. Date: 2008-08-21; US2007-0987720P Applic. Date: 2007-11-13; US2008-0054104P Applic. Date: 2008-05-16

Inventor: HILL MALCOLM (US)

A1 Published: 2009-05-14

Title: MONO-, DI- AND POLYOL PHOSPHATE ESTERS IN PERSONAL CARE FORMULATIONS

Applicant: RHODIA (US)

Application No.: US2009-0349401 Applic. Date: 2009-01-06

Abstract: A hydrophilized personal care formulation, which can be in the form of a hand or body soap (liquid or bar), lipstick, body wash, makeup remover, skin cleaner, hair conditioner, skin or hair moisturizer. The formulation employs an organophosphorus material or a mixture of an organophosphorus material, for example, mono-, di-, and polyol phosphate esters.

Priority: US2009-0349401 Applic. Date: 2009-01-06; US2008-0137589 Applic. Date: 2008-06-12; US2007-0943487P Applic. Date: 2007-06-12

Inventor: FUTTERER TOBIAS JOHANNES (SG); HOUGH LAWRENCE ALAN (US); REIERSON ROBERT LEE (US)

A1 Published: 2009-05-14

Title: Regulation of T Cell-Mediated Immunity by D Isomers of Inhibitors of Indoleamine-2,3-Dioxygenase

Applicant: MED COLLEGE GEORGIA RES INST (US)

Application No.: US2008-0175518 Applic. Date: 2008-07-18

Abstract: The present invention provides improved treatment methods by the administration of the non-physiologic D-isomer of an IDO inhibitor.

Priority: US2008-0175518 Applic. Date: 2008-07-18; US2004-0780150 Applic. Date: 2004-02-17; US2003-0459489P Applic. Date: 2003-04-01; US2004-0538647P Applic. Date: 2004-01-22

Inventor: MUNN DAVID (US); MELLOR ANDREW (US)

A1 Published: 2009-05-14

Title: Polypeptide-Nucleic Acid Conjugate for Immunoprophylaxis or Immunotherapy for Neoplastic or Infectious Disorders

Applicant: UNIV JOHNS HOPKINS (US)

Application No.: US2008-0184246 Applic. Date: 2008-07-31

Abstract: The present invention discloses compositions which induce cross-activation of immune mediated and direct death signaling in targeted cells by exploiting the properties of a antibody/peptide-nucleic acid conjugate. The conjugate is able to simultaneously activate multiple death signaling mechanisms. Methods of using the conjugate of the present invention as an immunotherapeutic modality for the treatment or prevention of infectious disease, neoplastic diseases or other disorders.

Priority: US2008-0184246 Applic. Date: 2008-07-31; US2007-0007895P Applic. Date: 2007-07-31; US2008-0022173P Applic. Date: 2008-01-18

Inventor: BEDI ATUL (US); RAVI RAJANI (US); LI SHULIN (US)

A1 Published: 2009-05-14

Title: OLIVE OIL FORMULATION FOR PAIN RELIEF

Applicant: KIMBERLY CLARK CO (US)

Application No.: US2007-0938596 Applic. Date: 2007-11-12

Abstract: The present disclosure generally relates to methods and compositions for reducing inflammation and/or pain, and more particularly, to compositions comprising an NSAID and oleocanthal and/or a related compound. The compositions are particularly suitable for topical delivery and may be used to relieve the effects of arthritis.

Priority: US2007-0938596 Applic. Date: 2007-11-12

Inventor: FELDKAMP JOSEPH R (US); SERRA LAURA (US); JOSEPH PIERRE (US); CUNNINGHAM COREY (US)

A1 Published: 2009-05-14

Title: CORTICOSTEROID COMPOSITIONS

Applicant: MERITAGE PHARMA INC (US)

Application No.: US2008-0269816 Applic. Date: 2008-11-12

Abstract: Provided herein are methods for treating, preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.

Priority: US2008-0269816 Applic. Date: 2008-11-12; US2008-0035348P Applic. Date: 2008-03-10; US2008-0054103P Applic. Date: 2008-05-16; US2008-0054105P Applic. Date: 2008-05-16; US2007-0012012P Applic. Date: 2007-12-06; US2008-0054107P Applic. Date: 2008-05-16; US2007-0015998P Applic. Date: 2007-12-21; US2008-0019818P Applic. Date: 2008-01-08; US2008-0034941P Applic. Date: 2008-03-07; US2008-0054106P Applic. Date: 2008-05-16; US2008-0090658P Applic. Date: 2008-08-21; US2007-0987720P Applic. Date: 2007-11-13; US2008-0054104P Applic. Date: 2008-05-16

Inventor: PHILLIPS ELAINE (US); HILL MALCOLM (US); LICALSI CYNTHIA (US); DESHMUKH HEMANT (US); JOHNSON KEITH (US)

A1 Published: 2009-05-14

Title: GASTROINTESTINAL DELIVERY SYSTEMS

Applicant: MERITAGE PHARMA INC (US)

Application No.: US2008-0269821 Applic. Date: 2008-11-12

Abstract: Provided herein are compositions suitable for the delivery of therapeutic agents to the gastrointestinal tract. Also provided herein are methods for treating, preventing or alleviating disorders of the gastrointestinal tract, for example, those involving the esophagus, by orally administering compositions described herein.

Priority: US2008-0269821 Applic. Date: 2008-11-12; US2008-0054105P Applic. Date: 2008-05-16; US2007-0012012P Applic. Date: 2007-12-06; US2008-0054107P Applic. Date: 2008-05-16; US2007-0015998P Applic. Date: 2007-12-21; US2008-0019818P Applic. Date: 2008-01-08; US2008-0034941P Applic. Date: 2008-03-07; US2008-0054106P Applic. Date: 2008-05-16; US2008-0090658P Applic. Date: 2008-08-21; US2007-0987720P Applic. Date: 2007-11-13; US2008-0054104P Applic. Date: 2008-05-16

Inventor: PHILLIPS ELAINE (US); HILL MALCOLM (US)

A1 Published: 2009-05-14

Title: Method and Pharmaceutical Composition for Treating Psoriasis, Squamous Cell Carcinoma and/or Parakeratosis by Inhibiting Expression of Squamous Cell Carcinoma-Related Antigen

Applicant: SHISEIDO CO LTD (JP)

Application No.: US2005-0886475 Applic. Date: 2005-09-22

Abstract: In a first aspect thereof, the present invention provides a method for treatment and/or prevention of a disease selected from the group consisting of psoriasis and squamous cell carcinoma by inhibiting the expression of squamous cell carcinoma antigen (SCCA) by cells. In another aspect thereof, the present invention provides a method for screening for substances that inhibit epidermal parakeratosis, wherein the activity of a candidate substance that inhibits cysteine protease inhibitory activity possessed by squamous cell carcinoma antigen 1 (SCCA-1) is used as an indicator.

Priority: JP2005-0080566 Applic. Date: 2005-03-18; WO2005-JP18074 Applic. Date: 2005-09-22

Inventor: HIBINO TOSHIHIKO (JP); NAKANISHI JOTARO (JP); KATAGIRI CHIKA (JP)

A1 Published: 2009-05-14

Title: ADMIXTURE OF EXTRACTS OF PLANTS OF THE GENUS ROSMARINUS AND CAROTENOIDS FOR TREATING CUTANEOUS SYMPTOMS OF AGING

Applicant: OREAL (FR); NESTEC SA (CH)

Application No.: US2008-0121914 Applic. Date: 2008-05-16

Abstract: Intimate admixtures of at least one carotenoid and at least one extract of at least one plant of the genus Rosmarinus are well suited for treating the undesirable cutaneous signs of skin aging, in particular the degradation of the skin and/or of the mucous membranes by inhibiting the activity and/or the expression of collagenases and by increasing the synthesis of collagen.

Priority: US2008-0121914 Applic. Date: 2008-05-16; FR2000-0013757 Applic. Date: 2000-10-26; US2003-0424751 Applic. Date: 2003-04-28; WO2001-FR03314 Applic. Date: 2001-10-25

Inventor: BRETON LIONEL (FR); BAUR MARKUS (DE)

A1 Published: 2009-05-14

Title: ACTIVE SUBSTANCE COMBINATIONS OF ANISE FRUIT EXTRACT AND WHITE TEA EXTRACT

Applicant: BEIERSDORF AG (DE)

Application No.: US2008-0258934 Applic. Date: 2008-10-27

Abstract: An active substance combination which comprises anise fruit extract and white tea extract and a cosmetic preparation comprising same. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.

Priority: DE2007-10052536 Applic. Date: 2007-11-01

Inventor: KROEPKE RAINER (DE); FAENGER SABINE (DE); MUMMERT CHRISTOPHER (DE); SCHULZ JENS (DE)

A1 Published: 2009-05-14

Title: Ameliorating Agent for Metabolic Syndrome

Application No.: US2007-0225561 Applic. Date: 2007-03-23

Abstract: The object is to provide a food-derived effective ingredient which can promote the reduction in accumulated fats or the like. Disclosed is a body fat reduction-promoting agent, a leptin production-promoting agent, an anorexigenic agent, a PAI-1 production-suppressing agent or an anti-thrombotic agent, each comprising an extract from a chestnut astringent skin as an active ingredient. The extract from a chestnut astringent skin, which is a natural component, can be used as an extremely safe body fat reduction-promoting agent, leptin production-promoting agent, anorexigenic agent, PAI-1 production-suppressing agent or anti-thrombotic agent. Particularly, the body fat reduction-promoting agent can reduce an accumulated visceral fat and therefore can directly prevent obesity.

Priority: JP2006-0083003 Applic. Date: 2006-03-24; WO2007-JP55987 Applic. Date: 2007-03-23

Inventor: KUWAHARA AKIKO (JP); NAKANISHI AYAKO (JP); SUDA KAZUMA (JP)

A1 Published: 2009-05-14

Title: HARD SURFACE CLEANING COMPOSITION WITH HYDROPHILIZING AGENT AND METHOD FOR CLEANING HARD SURFACES

Applicant: RHODIA (US)

Application No.: US2009-0349490 Applic. Date: 2009-01-06

Abstract: A composition for cleaning or rinsing hard surfaces in an aqueous or aqueous/alcoholic medium including at least one organophosphorus material for contributing to said surfaces antideposition and/or antiadhesion properties with regard to soiling substances capable of being deposited on the surfaces.

Priority: US2009-0349490 Applic. Date: 2009-01-06; US2008-0137738 Applic. Date: 2008-06-12; US2007-0943517P Applic. Date: 2007-06-12

Inventor: FUTTERER TOBIAS JOHANNES (SG); HOUGH LAWERENCE ALAN (US); REIERSON ROBERT LEE (US)

A1 Published: 2009-05-14

Title: Antimicrobially Active Peptides

Applicant: UNIV EBERHARD KARLS (DE)

Application No.: US2008-0043920 Applic. Date: 2008-03-06

Abstract: An antimicrobially active peptide comprises the DCD protein or a fragment of DCD, preferably derived from the C-terminal region.

Priority: US2008-0043920 Applic. Date: 2008-03-06; DE2001-1029983 Applic. Date: 2001-06-13; US2003-0735481 Applic. Date: 2003-12-12; WO2002-EP06238 Applic. Date: 2002-06-07

Inventor: GARBE CLAUS (DE); SCHITTEK BIRGIT (DE)

A1 Published: 2009-05-14

Title: Peptides Exhibiting Efficacies of Improvement in Skin Conditions or Treatment of Periodental Diseases

Application No.: US2006-0083970 Applic. Date: 2006-10-24

Abstract: The present invention relates to a composition for improving a skin condition or treating a periodontal disease, which comprises as an active ingredient a basic fibroblast growth factor-derived peptide. The peptides of this invention exhibit superior efficacies and much better stability and skin permeation than natural-occurring bFGF. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on improvement in skin conditions and treatment of periodontal diseases. In addition, the peptides of this invention can be advantageously applied to pharmaceutical compositions, cosmetics, tooth-paste and compositions for mouth cleaning and caring.

Priority: KR2005-0100391 Applic. Date: 2005-10-24; WO2006-KR04350 Applic. Date: 2006-10-24

Inventor: CHUNG YONG JI (KR); KIM YOUNG DEUG (KR); KIM CHUNG RYUL (KR)

A1 Published: 2009-05-14

Title: MAPK/ERK KINASE INHIBITORS

Applicant: TAKEDA PHARMACEUTICAL (JP)

Application No.: US2008-0267353 Applic. Date: 2008-11-07

Abstract: Compounds of the following formula are provided for use with MEK: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Priority: US2008-0267353 Applic. Date: 2008-11-07; US2007-0987279P Applic. Date: 2007-11-12

Inventor: ADAMS MARK (US); DONG QING (US); KANOUNI TOUFIKE (US); KALDOR STEPHEN W (US); SCORAH NICHOLAS (US); WALLACE MICHAEL B (US)

A1 Published: 2009-05-14

Title: SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE

Applicant: JANSSEN PHARMACEUTICA NV (BE)

Application No.: US2005-0572563 Applic. Date: 2005-07-25

Abstract: This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

Priority: US2005-0572563 Applic. Date: 2005-07-25; EP2004-0077172 Applic. Date: 2004-07-28; US2004-0592182P Applic. Date: 2004-07-29; WO2005-EP53612 Applic. Date: 2005-07-25

Inventor: VERDONCK MARC GUSTAAF CELINE (BE); ANGIBAUD PATRICK RENE (FR); ROUX BRUNO (FR); PILATTE ISABELLE NOELLE CONSTANCE (FR); TEN HOLTE PETER (BE); ARTS JANINE (BE); VAN EMELEN KRISTOF (BE)

A1 Published: 2009-05-14

Title: Cosmetic Compositions Comprising Hydroxyfatty Acids

Application No.: US2006-0990490 Applic. Date: 2006-09-14

Abstract: The present invention is concerned with novel cosmetic or pharmaceutical compositions. More particularly, the invention is concerned with novel cosmetic or pharmaceutical compositions for treating or preventing any symptoms caused by negative developments of the physiological homeostasis of healthy skin, as well as for the promotion of hair growth and protection from hair loss.

Priority: EP2005-0020779 Applic. Date: 2005-09-23; EP2005-0020905 Applic. Date: 2005-09-26; WO2006-EP08961 Applic. Date: 2006-09-14

Inventor: BEUMER RAPHAEL (DE)

A1 Published: 2009-05-14

Title: SKIN TREATMENT DEVICE

Application No.: US2008-0139093 Applic. Date: 2008-06-13

Abstract: A personal skin polishing or microdermabrasion device having a convenient form factor with a applicator attached to a contoured housing with a handle portion. The housing contains a battery, a cordless motor and a gear box to provide an appropriate rotational velocity to the output shaft that is coupled to the applicator. The applicator may be a foam material selected to cushion the skin from excessive abrasion to the particles in a personal care composition to be used with device, and to have a porosity that will enable the foam to interact with the particles and enhance the skin polishing effect.

Priority: US2008-0139093 Applic. Date: 2008-06-13; US2007-0934439P Applic. Date: 2007-06-13

Inventor: HASENOEHRL ERIK JOHN (US); FANTA KEITH DAVID (US); KEMP HELEN ROCHELLE (US); PINYAYEV ALEKSEY MIKHAILOVICH (US); MCDANIEL JOHN ANDREW (US); VERNON PAUL JOHN EDWARD (US); TANNER PAUL ROBERT (US); CORTINA LINDA EVA (US); LEPPLA NANCY LORINCZ (US); ZIMMERMAN DEAN ARTHUR (US)

A1 Published: 2009-05-21

Title: GLYCEROL ETHERS VEHICLE AND PHARMACEUTICAL COMPOSITIONS THEREOF

Applicant: FOAMIX LTD (IL)

Application No.: US2008-0275532 Applic. Date: 2008-11-21

Abstract: The present disclosure teaches unique foamable vehicles or carriers comprising at least one glycerol ether, a stabilizer, and water; pharmaceutical and cosmetic compositions with potentially enhanced skin delivery and their uses.

Priority: US2008-0275532 Applic. Date: 2008-11-21; US2007-0989738P Applic. Date: 2007-11-21

Inventor: TAMARKIN DOV (IL); BESONOV ALEX (IL)

A1 Published: 2009-05-21

Title: STABILIZED PREPARATIONS COMPRISING PHENOLIC COMPOUNDS AND BENZOPHENONES

Applicant: SYMRISE GMBH & CO KG (DE)

Application No.: US2007-0159866 Applic. Date: 2007-01-05

Abstract: The present invention relates primarily to a cosmetic and/or pharmaceutical preparation comprising of consisting of one or more phenolic compounds of the formula (I) where for formula (I) it is the case that: R1, R2, R3, R4 and R5 are independently of one another hydrogen, halogen, an OH group, methyl or a linear or branched alkyl having 2, 3, 4 or 5 C atoms, with 1, 2 or 3 different radicals from the group R1, R2, R3, R4 and R5 simultaneously representing an OH group, R6 and R7 are independently of one another hydrogen, methyl or a linear or branched alkyl having 2, 3, 4 or 5 C atoms, n is an integer from 0 to 20 and R8 is methyl or a linear or branched alkyl having 2 or 3 C atoms, a cycloalkyl having 3, 4, 5, 6 or 7 C atoms or a phenyl and one or more compounds of the formula (II) where for formula (II) it is the case that:; R9, R10, R11 and R12 independently of one another are hydrogen, methyl, an OH group or a group -O-R13 and R13 is methyl or a linear or branched alkyl having 2, 3, 4, 5, 6, 7, 8, 9 or 10 C atoms, and to uses of compounds of the formula (II) for stabilizing compounds of the formula (I), and also to methods of stabilizing compounds of the formula (I).

Priority: US2007-0159866 Applic. Date: 2007-01-05; US2006-0756205P Applic. Date: 2006-01-05; US2006-0804319P Applic. Date: 2006-06-09; WO2007-EP50123 Applic. Date: 2007-01-05

Inventor: LANGE SABINE (DE); SCHMAUS GERHARD (DE); VIELHABER GABRIELE (DE); SCHAPER KARIN (DE)

A1 Published: 2009-05-21

Title: COSMETIC RINSABLE MASK TYPE COMPOSITION FOR SKIN CARE

Applicant: LVMH RECH (FR)

Application No.: US2007-0281736 Applic. Date: 2007-04-13

Abstract: The present invention relates to a cosmetic composition of rinse-off mask type for the care of the skin, for example of the face. The invention relates to a cosmetic composition of rinse-off mask type for the care of the skin, characterized in that it comprises at least one superabsorbent polymer or copolymer of water-retaining type, in the form of particles in the substantially completely hydrated state, said particles having, in the dry or nonhydrated state, a mean particle size of between 5 and 100 mum, advantageously between 20 and 50 mum, in particular between 20 and 30 mum. The composition applied to the skin provides a very refreshing effect and can be easily rinsed off after use.

Priority: FR2006-0003421 Applic. Date: 2006-04-14; WO2007-FR51114 Applic. Date: 2007-04-13

Inventor: JONCHIERE CLAIRE (FR)

A1 Published: 2009-05-21

Title: Topical Composition for Treating Pain

Application No.: US2007-0942409 Applic. Date: 2007-11-19

Abstract: Topical compositions having as the active ingredient a hydrophilic material, such as a polyalkylene oxide homopolymer or copolymer, and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of a cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. In the preferred embodiment, the formulation is a gel. The composition may contain a penetration enhancer, most preferably one with membrane disruptive properties. In one embodiment, the compositions are incorporated onto or into disposables such as hemorrhoid wipes, gauze, sponge, bandages, and wraps; mouth guards, dental trays; needles or catheters; adult diapers; gloves, socks or wrist bands, for ease of application. The composition is applied topically to a site at or adjacent to a painful region.; The composition is reapplied as necessary. Pain relief is typically obtained within minutes and lasts for periods of variable duration ranging from minutes to several hours and even, in some cases, days. The composition is variably effective to treat visceral, somatic and neuropathic pain both acute and chronic as well as muscle pain and stiffness and joint pain and stiffness.

Priority: US2007-0942409 Applic. Date: 2007-11-19

Inventor: ORONSKY BRYAN TODD (US); ORONSKY NEIL CHARLES (US); ORONSKY ARNOLD L (US)

A1 Published: 2009-05-21

Title: Cosmetic active ingredient composed of arginine ferrulate and a microalgae extract and its uses

Application No.: US2007-0293308 Applic. Date: 2007-03-27

Abstract: The invention relates to a novel cosmetic active ingredient composed of a microalgae extract and arginine ferrulate, its uses for activating proteasome and the production of thioredoxin, a cosmetic composition containing it and the use of such a cosmetic composition for combating skin ageing.

Priority: FR2006-0002628 Applic. Date: 2006-03-27; WO2007-FR00527 Applic. Date: 2007-03-27

Inventor: MEKIDECHE NICOLE (FR)

A1 Published: 2007-03-29
Patent No.: US2009130188A9 Issued: 2009-05-21

Title: Acrylic pressure sensitive adhesives

Applicant: NAT STARCH CHEM INVEST

Application No.: US2005-0238277 Applic. Date: 2005-09-29

Abstract: Solution acrylic polymers suitable for dispersing drugs are particularly useful in transdermal drug delivery applications.

Priority: US2005-0238277 Applic. Date: 2005-09-29

Inventor: FOREMAN PAUL B (US); LUCIANO ALLISON (US)

A1 Published: 2009-05-21

Title: Transdermal System for the Delivery of Sufentanil and Its Analogs

Applicant: LABTEC GMBH (DE)

Application No.: US2008-0255466 Applic. Date: 2008-10-21

Abstract: Methods and systems for the transdermal delivery of sufentanil and its analogs are described, from patches having a unique pharmacodynamic profile that can be used to treat persistent pain over extended periods and acute pain episodes of limited duration.

Priority: DE2006-10019293 Applic. Date: 2006-04-21; WO2007-EP03498 Applic. Date: 2007-04-20

Inventor: BREITENBACH ARMIN (DE); KLAFFENBACH PETER (DE); LEHRKE INGO (DE); VOLLMER ULRIKE (DE)

A1 Published: 2009-05-21

Title: EXTERNAL PREPARATION FOR SKIN

Application No.: US2005-0912433 Applic. Date: 2005-09-27

Abstract: The present invention provides an external preparation for skin which contains 5-aminolevulinic acids as active components and which is excellent in skin-beautifying effects such as prevention/amelioration of skin roughness, dry skin, wrinkles, sagging and flecks of skin, and improvement of turnover of corneum; and in an ameliorating effect on skin diseases such as atopic dermatitis. An external preparation for skin which contains one or more compounds selected from the group consisting of 5-aminolevulinic acid, its salt and a derivative of them; and an iron compound; as active components, is used.

Priority: JP2005-0131171 Applic. Date: 2005-04-28; WO2005-JP17681 Applic. Date: 2005-09-27

Inventor: ITO YOSHIYASU (JP)

A1 Published: 2009-05-21

Title: SILICATE CONTAINING COMPOSITIONS AND METHODS OF TREATMENT

Applicant: OAKS PHARMACEUTICAL CORP 7

Application No.: US2008-0250624 Applic. Date: 2008-10-14

Abstract: The present invention relates to compositions comprising a silicate and methods of use thereof. In particular, the compositions of the present invention are suitable for treating inflammatory conditions, cancer, bacterial and viral infections, and infected and uninfected wounds. The compositions of the present invention can also be useful in treating spinal cord injury, tissue remodeling, and promoting bone growth and repair.

Priority: US2008-0250624 Applic. Date: 2008-10-14; US2007-0960794P Applic. Date: 2007-10-15; US2008-0071754P Applic. Date: 2008-05-15; US2008-0090833P Applic. Date: 2008-08-21

Inventor: STANLEY SR RICHARD THOMAS (US); STANLEY DAVID EDWARD (US)

A1 Published: 2009-05-21

Title: GEF-H1b: biomarkers, complexes, assays and therapeutic uses thereof

Applicant: SUGEN INC

Application No.: US2008-0232134 Applic. Date: 2008-09-11

Abstract: The present invention relates to diagnosing abnormal cell proliferation in biological samples and screening for drugs which inhibit, reduce or abolish cell growth, especially tumorigenic cell growth, by detecting a phosphovariant isoform of a guanine nucleotide exchange factor biomarker, such as the novel GEF-H1S.

Priority: US2008-0232134 Applic. Date: 2008-09-11; US2003-0611671 Applic. Date: 2003-07-02; US2002-0393600P Applic. Date: 2002-07-05; US2003-0460053P Applic. Date: 2003-04-04

Inventor: SMEAL TOD R (US); CALLOW MARINELLA G (US); JALLAL BAHIJA (US); ZOZULYA SERGEY (US); GISHIZKY MIKHAIL L (US)

A1 Published: 2009-05-21

Title: Combinations

Application No.: US2008-0290106 Applic. Date: 2008-10-27

Abstract: The present invention relates to a combination, especially a pharmaceutical composition, comprising (a) an insulin secretion enhancer or a pharmaceutically acceptable salt thereof and (b) at least one of the active ingredients selected from the group consisting of (i) HMG-Co-A reductase inhibitors or a pharmaceutically acceptable salt thereof; and (ii) ACE inhibitors or a pharmaceutically acceptable salt thereof; and, in case of a pharmaceutical composition, a pharmaceutically acceptable carrier.

Priority: US2008-0290106 Applic. Date: 2008-10-27; US2003-0362341 Applic. Date: 2003-06-18; WO2001-EP09586 Applic. Date: 2001-08-20; US2000-0643642 Applic. Date: 2000-08-22

Inventor: ALLISON MALCOLM (CH); GATLIN MARJORIE REGAN (US)

A1 Published: 2009-05-21

Title: THIAZOLYL-DIHYDRO-CHINAZOLINE

Applicant: BOEHRINGER INGELHEIM INT (DE)

Application No.: US2009-0351017 Applic. Date: 2009-01-09

Abstract: Disclosed are compounds of general formula (I), wherein the groups A, R1, R2, Ra and Rb have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers and the mixtures thereof, and optionally the pharmacologically acceptable acid addition salts, solvates and hydrates thereof, and processes for preparing these thiazolyl-dihydro-quinazolines and the use thereof as pharmaceutical compositions.

Priority: US2009-0351017 Applic. Date: 2009-01-09; EP2006-0112296 Applic. Date: 2006-04-06; US2007-0690355 Applic. Date: 2007-03-23

Inventor: BRANDL TRIXI (CH); MAIER UDO (DE); HOENKE CHRISTOPH (DE); JOERGENSEN ANNE T (DK); PAUTSCH ALEXANDER (DE); BREITFELDER STEFFEN (DE); GRAUERT MATTHIAS (DE); HOFFMANN MATTHIAS (DE); SCHEUERER STEFAN (DE); ERB KLAUS (DE); PIEPER MICHAEL (DE); PRAGST INGO (DE)

A1 Published: 2009-05-21

Title: Gelatin-containing topical composition

Applicant: AQUA BIO TECHNOLOGY ASA (NO)

Application No.: US2006-0914722 Applic. Date: 2006-05-19

Abstract: This invention provides a topical pharmaceutical or cosmetic composition comprising a pharmaceutically or cosmetically active agent and a gelling agent, characterized in that said gelling agent comprises a fish gelatin and a polysaccharide.

Priority: WO2006-GB01874 Applic. Date: 2006-05-19; GB2005-0010286 Applic. Date: 2005-05-19; GB2006-0007174 Applic. Date: 2006-04-10

Inventor: DRAGET KURT INGAR (NO); HAUG INGVILD JOHANNE (NO); SMIDSROD OLAV AASMUND (NO)

A1 Published: 2009-05-21

Title: COMPOSITION FOR PROTECTING SKIN

Application No.: US2009-0354982 Applic. Date: 2009-01-16

Abstract: Disclosed are a composition for protecting skin and uses thereof. The composition comprises sphingomyelin as an active ingredient and protects the skin by inhibiting skin aging, treating a skin wound and improving a skin barrier.

Priority: US2009-0354982 Applic. Date: 2009-01-16; KR2003-0068932 Applic. Date: 2003-10-02; KR2004-0075864 Applic. Date: 2004-09-22; US2007-0574275 Applic. Date: 2007-04-20; WO2004-KR02517 Applic. Date: 2004-10-01

Inventor: PARK CHANGSEO (KR); KIM SUNKI (KR); KIM JINWOOK (KR); KANG HYEONGJOON (KR); HAN BOKYUNG (KR); LEE YOUNGGON (KR); CHUNG SOYOUNG (KR); CHOI WANGKEUN (KR); NAM SANG JUNE (KR)

A1 Published: 2009-05-28

Title: Antihistamine/Corticosteroid preparations for the treatment of atopic dermatitis

Application No.: US2007-0945842 Applic. Date: 2007-11-27

Abstract: It has been found that the combination of an antihistamine with a corticosteroid is more effective in the treatment of atopic dermatitis than either one used separately. The synergistic effect in some cases results in the disappearance of the atopic dermatitis lesion within one to five days with little or no relapse. Compositions and the methods of utilizing these preparations are disclosed.

Priority: US2007-0945842 Applic. Date: 2007-11-27

Inventor: DUGGER HARRY A (US)

A1 Published: 2009-05-28

Title: Stilbene Like Compounds as Novel HDAC Inhibitors

Applicant: ORCHID RES LAB LTD (IN)

Application No.: US2006-0084430 Applic. Date: 2006-11-06

Abstract: The present invention relates to novel stilbene like compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel stilbene like compounds of the general formula (I). Also included is a method for treatment of cancer, psoriasis, proliferative conditions and conditions mediated by HDAC, in a mammal comprising administering an effective amount of a novel compound of formula (I) as described above.

Priority: IN2005-CH01644 Applic. Date: 2005-11-10; WO2006-IB03114 Applic. Date: 2006-11-06

Inventor: SRINIVAS AKELLA S S V (IN); BALAN URKALAN K (IN); PUNTHALIR NARAYANA S (IN); VELMURUGAN RAMA S (IN); RAJAGOPAL SRIRAM (IN); REDDY GADDAM O (IN); KACHHADIA VIRENDRA (IN)

A1 Published: 2009-05-28

Title: Use of Hydrophobin-Polypeptides and Conjugates From Hydrophobin-Polypeptides Having Active and Effect Agents and the Production Thereof and Use Thereof In the Cosmetic Industry

Applicant: BASF AG (DE)

Application No.: US2006-0922650 Applic. Date: 2006-06-23

Abstract: Cosmetic composition for the treatment of keratin-containing materials, mucosa and teeth, comprising at least one hydrophobin polypeptide sequence (i) [tables id="TABLE-US-00001" num="00001"] [table frame="none" colsep="0" rowsep="0" tabstyle="monospace"] [tgroup align="left" colsep="0" rowsep="0" cols="2"] [colspec colname="1" colwidth="217pt" align="right"/] [colspec colname="2" colwidth="0pt" align="left"/] [tbody valign="top"] [row] [entry](I)[/entry] [entry/] [/row] [/tbody] [/tgroup] [tgroup align="left" colsep="0" rowsep="0" cols="2"] [colspec colname="1" colwidth="217pt" align="left"/] [colspec colname="2" colwidth="0pt" align="left"/] [tbody valign="top"] [row] [entry]Xn-C1-X1-50-C2-X0-5-C3-Xp-C4-X1-100-C5-X1-50-C6-[/entry] [entry/] [/row] [row] [entry] [/entry] [/row] [row] [entry]X0-5-C7-X1-50-C8-Xm[/entry] [/row] [/tbody] [/tgroup] [/table] [/tables]

Priority: DE2005-10029704 Applic. Date: 2005-06-24; WO2006-EP63485 Applic. Date: 2006-06-23

Inventor: SUBKOWSKI THOMAS (DE); KAROS MARVIN (DE); LEMAIRE HANS-GEORG (DE); BARG HEIKO (DE); BOLLSCHWEILER CLAUS (DE)

A1 Published: 2009-05-28

Title: Transdermal sustained release drug delivery

Applicant: ALZA CORP (US)

Application No.: US2008-0288753 Applic. Date: 2008-10-23

Abstract: Provided herein are microprojections and microprojection arrays for delivering biologically active agents. Also provided herein are compositions suitable for coating such microprojections and microprojection arrays.

Priority: US2008-0288753 Applic. Date: 2008-10-23; US2007-0982119P Applic. Date: 2007-10-23

Inventor: AMERI MAHMOUD (US); MAA YUH-FUN (US)

A1 Published: 2009-05-28

Title: BACTERIAL EXTRACTS CULTURED IN THERMAL WATERS FOR TREATING SENSITIVE SKIN, MUCOUS MEMBRANES AND SCALPS

Applicant: OREAL (FR)

Application No.: US2008-0175129 Applic. Date: 2008-07-17

Abstract: Sensitive skin, mucous membranes and scalps are treated by administering to individuals in need of such treatment, thus effective amounts of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which includes at least one non-sulfurous mineral and/or thermal water, e.g., an extract derived from the bacterium Vitreoscilla filiformis, in particular the strain ATCC 15551, cultured in a medium enriched with water from La Roche Posay.

Priority: US2008-0175129 Applic. Date: 2008-07-17; FR2007-0056551 Applic. Date: 2007-07-17; US2007-0930000P Applic. Date: 2007-07-20

Inventor: BRETON LIONEL (FR); MAHE YANN (FR); MARTIN RICHARD (FR)

A1 Published: 2009-05-28

Title: Hydrocolloids and Process Therefor

Application No.: US2009-0350590 Applic. Date: 2009-01-08

Abstract: The present invention relates to a shampoo composition comprising a minced polygalactomannan hydrocolloid(s) in combination with a water soluble silicone compound.

Priority: US2009-0350590 Applic. Date: 2009-01-08; US2004-0014424 Applic. Date: 2004-12-16

Inventor: LEPILLEUR CAROLE A (US); FRUSCELLA JEFFREY A (US)

A1 Published: 2009-05-28

Title: MEDICAMENTS AND PROTEINS BASED ON TGF-BETA MONOMERS FOR THE TREATMENT OF WOUNDS

Application No.: US2007-0282472 Applic. Date: 2007-03-12

Abstract: There is provided the use of monomeric TGF-betas, or there fragments or derivatives, as medicaments. These medicaments preferably comprise monomeric TGF-beta3, or fragments or derivatives thereof. The medicaments provided may be used in the acceleration of wounding and/or the inhibition of scarring, in the promotion of epithelial regeneration, or in the prevention and/or treatment of fibrotic disorders.

Priority: WO2007-GB00834 Applic. Date: 2007-03-12; GB2006-0004966 Applic. Date: 2006-03-11

Inventor: FERGUSON MARK WILLIAM JAMES (GB); MELLOR PHILLIP (GB); LAVERTY HUGH GERARD (GB); OCCLESTON NICK (GB); O'KANE SHARON (GB); ATKINSON EMMA (GB)

A1 Published: 2009-05-28

Title: Compositions for External Application, Containing Adenosyl Cobalamin for Improvement of Skin Diseases

Application No.: US2006-0996574 Applic. Date: 2006-10-18

Abstract: The present invention relates to a composition for external application for improving a skin disease (e.g. psoriasis). Said composition contains adenosyl cobalamin (coenzyme B12), opt. in admixture with other cobalamins. Preferable said composition is present in the form of liposomal preparations, which are made of a phospholipid and cholesterol.

Priority: KR2005-0120648 Applic. Date: 2005-12-09; WO2006-KR04233 Applic. Date: 2006-10-18

Inventor: SHIN BYUNG CHEOL (KR); SEONG HASOO (KR); LEE AERI (KR); KONG JAE YANG (KR); CHEON HYAE GYEONG (KR); CHO YOUNG SIK (KR); JUN SUNG SOO (KR); JO YOUNG GWAN (KR)

A1 Published: 2009-05-28

Title: Skin treatment compositions and methods

Application No.: US2007-0986719 Applic. Date: 2007-11-26

Abstract: A skin treatment composition or cosmetic product comprising a) two or more active components, namely, at least one dermatological acid and at least one meroterpene and b) a dermatologically acceptable carrier.

Priority: US2007-0986719 Applic. Date: 2007-11-26

Inventor: CHAUDHURI RATAN K (US)

A1 Published: 2009-05-28

Title: COMPOSITIONS FOR THE TREATMENT OF GASTROINTESTINAL INFLAMMATION

Applicant: MERITAGE PHARMA INC (US)

Application No.: US2008-0269650 Applic. Date: 2008-11-12

Abstract: Provided herein are methods for treating, preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.

Priority: US2008-0269650 Applic. Date: 2008-11-12; US2008-0035348P Applic. Date: 2008-03-10; US2008-0054103P Applic. Date: 2008-05-16; US2008-0054105P Applic. Date: 2008-05-16; US2007-0012012P Applic. Date: 2007-12-06; US2008-0054107P Applic. Date: 2008-05-16; US2007-0015998P Applic. Date: 2007-12-21; US2008-0019818P Applic. Date: 2008-01-08; US2008-0034941P Applic. Date: 2008-03-07; US2008-0054106P Applic. Date: 2008-05-16; US2008-0090658P Applic. Date: 2008-08-21; US2007-0987720P Applic. Date: 2007-11-13; US2008-0054104P Applic. Date: 2008-05-16

Inventor: PHILLIPS ELAINE (US); HILL MALCOLM (US)

A1 Published: 2009-05-28

Title: COSMETIC AND PHARMACEUTICAL COMPOSITIONS COMPRISING ACE INHIBITORS AND/OR ANGIOTENSIN II RECEPTOR ANTAGONISTS

Applicant: ACE APS (DK)

Application No.: US2005-0573781 Applic. Date: 2005-08-18

Abstract: In one aspect, the present invention relates to use of an ACE inhibitor and/or angiotensin II receptor antagonist for the preparation of a medicament for the treatment of a dermatological disorder, particularly by topical application of said ACE inhibitor and/or angiotensin II receptor antagonist. The present invention also provides cosmetic methods for improving and/or maintaining the skin tone of an individual suffering from, or at risk of suffering from, a dermatological disorder, said method comprising contacting the skin of said individual with an ACE inhibitor and/or angiotensin II receptor antagonist.

Priority: US2005-0573781 Applic. Date: 2005-08-18; DK2004-0001247 Applic. Date: 2004-08-18; US2004-0607919P Applic. Date: 2004-09-08; WO2005-DK00530 Applic. Date: 2005-08-18

Inventor: BONNICHSEN RICHARD (SC)

A1 Published: 2009-05-28

Title: COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS

Applicant: IRM LLC (BM)

Application No.: US2006-0815096 Applic. Date: 2006-02-03

Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPARdelta.

Priority: US2006-0815096 Applic. Date: 2006-02-03; US2005-0649962P Applic. Date: 2005-02-03; WO2006-US03924 Applic. Date: 2006-02-03

Inventor: COW CHRISTOPHER (US); EPPLE ROBERT (US); WANG XING (US); XIE YONGPING (US); SEIDEL HANS MARTIN (US)

A1 Published: 2009-05-28

Title: SPIRO IMIDOZOLE DERIVATIVES AS PPAR MODULATORS

Applicant: IRM LLC (BM)

Application No.: US2007-0160302 Applic. Date: 2007-01-25

Abstract: The invention provides compounds (Ia), (Ib) and (Ic), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.

Priority: US2007-0160302 Applic. Date: 2007-01-25; US2006-0763557P Applic. Date: 2006-01-30; WO2007-US02315 Applic. Date: 2007-01-25

Inventor: EPPLE ROBERT (US); RUSSO ROSS (US); AZIMIOARA MIHAI (US); COW CHRISTOPHER (US); MOLTENI VALENTINA (US); LI XIAOLIN (US); CHIANELLI DONATELLA (US)

A1 Published: 2009-05-28

Title: Formulations of Indanylamines and the Use Thereof as Local Anesthetics and as Medication for Chronic Pain

Applicant: BRIDGE PHARMA INC (US)

Application No.: US2006-0991771 Applic. Date: 2006-09-22

Abstract: Dermal and mucosal formulations of 2-[2-(N-phenyl-N-2-indanyl)aminoethyl]piperidine, characterized by rapid dermal and mucosal absorption and long duration of therapeutic activity are provided. Also provided are solutions of 2-[2-(N-phenyl-N-2-indanyl)aminoethyl]piperidine for injection, characterized by short onset time and long duration of activity. Formulations containing both 2-[2-(N-phenyl-N-2-indanyl)aminoethyl]piperidine and capsaicin are also provided.

Priority: US2006-0991771 Applic. Date: 2006-09-22; US2005-0719904P Applic. Date: 2005-09-23; US2006-0839783P Applic. Date: 2006-08-24; WO2006-US37070 Applic. Date: 2006-09-22

Inventor: ABERG A K GUNNAR (US); JOHNSON KEITH (US)

A1 Published: 2009-05-28

Title: METHOD FOR IMAGING AND TREATING ORGANS AND TISSUES

Applicant: ONCOFLUOR INC (US)

Application No.: US2008-0212582 Applic. Date: 2008-09-17

Abstract: The present invention provides methods and compositions for detecting and treating malignant tissue, organs or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus or by a route providing access to the tissue or organ, with a composition comprising an antibody/fragment that is tagged with a fluorophore and a therapeutic isotope molecule, which specifically binds to the targeted organ, tissue or cell.

Priority: US2008-0212582 Applic. Date: 2008-09-17; US2007-0973630P Applic. Date: 2007-09-19

Inventor: LUIKEN GEORGE A (US)

A1 Published: 2009-06-04

Title: COSMETIC COMPOSITION COMPRISING ASCORBIC ACID 2-GLUCOSIDE AND ERGOTHIONEINE

Applicant: LVMH RECH

Application No.: US2008-0275151 Applic. Date: 2008-11-20

Abstract: This invention relates to a cosmetic composition allowing the effects of skin aging to be reduced or delayed, comprising as the cosmetically active ingredients ascorbic acid 2-glucoside and ergothioneine. The invention also relates to the use of these cosmetically active ingredients in a cosmetic composition as agents to stimulate DNA repair enzymes, particularly enzymes to repair oxidised DNA bases in dermal and epidermal cells. Finally, the invention relates to a cosmetic treatment process involving this use.

Priority: FR2007-0059469 Applic. Date: 2007-11-30

Inventor: KURFURST ROBIN (FR); BONNET-DUQUENNOY MATHILDE (FR)

A1 Published: 2009-06-04

Title: 5-SUBSTITUTED ISOINDOLINE COMPOUNDS

Application No.: US2008-0130445 Applic. Date: 2008-05-30

Abstract: This invention relates to 5-substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.

Priority: US2008-0130445 Applic. Date: 2008-05-30; US2007-0897339 Applic. Date: 2007-08-31; US2007-0925513P Applic. Date: 2007-04-20; US2007-0937782P Applic. Date: 2007-06-28

Inventor: MULLER GEORGE W (US); CHEN ROGER SHEN-CHU (US); RUCHELMAN ALEXANDER L (US)

A1 Published: 2009-06-04

Title: Novel Gene Disruptions, Compositions and Methods Relating Thereto

Applicant: GENENTECH INC (US); LEXICON PHARMACEUTICALS INC (US)

Application No.: US2007-0814606 Applic. Date: 2007-05-21

Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO844, PRO1131 or PRO5992 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

Priority: US2007-0814606 Applic. Date: 2007-05-21; US2006-0820717P Applic. Date: 2006-07-28; WO2007-US69347 Applic. Date: 2007-05-21

Inventor: DE SAUVAGE FREDERIC (US); FILVAROFF ELLEN (US); JUNUTULA JAGATH REDDY (US); PAYNE BOBBY JOE (US); SHI ZHENG-ZHENG (US); SPARKS MARY JEAN (US); VOGEL PETER (US)

A1 Published: 2009-06-04

Title: Therapeutic composition for use in the prevention and treatment of bone metastases

Application No.: US2006-0921421 Applic. Date: 2006-05-31

Abstract: The invention is relates to drugs on the basis of antibodies against non-cellular bone matrix proteins, especially BSP, for use in the prevention and treatment of bone metastases. According to the invention, the antibodies are induced in the patient by recombinantly expressing antigenic determinants of bone matrix proteins in Listeria and anchoring them on the surfaces thereof. The antigenic determinants are selected according to whether they are characteristic of antigens that are expressed by the tumor cells themselves.

Priority: WO2006-EP05191 Applic. Date: 2006-05-31; DE2005-10024836 Applic. Date: 2005-05-31; DE2006-10004612 Applic. Date: 2006-02-01

Inventor: JOCHEM RALF (DE); ARMBRUSTER FRANZ PAUL (DE); BRAUN VEIT (DE); VON EICHEL-STREIBER CHRISTOPH (DE)

A1 Published: 2009-06-04

Title: Cosmetic Composition with Anti-Free Radical Activity

Applicant: LVMH RECH (FR)

Application No.: US2007-0883779 Applic. Date: 2007-06-11

Abstract: A cosmetic composition has an association of at least three of the following substances with anti-free radical activity, selected from: A cosmetic composition has an association of at least three of the following substances with anti-free radical activity, selected from: 1) ebselen; or idebenone; or an association of the two; and 2) at least one substance with anti-free radical activity, or at least two substances with anti-free radical activity for obtaining said association of at least three substances with anti-free radical activity, said substance(s) being selected from: a) a substance of chemical formula (I) below: in which:; R=a linear or branched, saturated or unsaturated C1-C16 hydrocarbon chain; and R1, R2 and R3 are identical or different and are a hydrogen atom or a methyl or methoxy radical, and its esters; b) an extract of Edelweiss; c) an extract of Emblica; and d) N-acetylcysteine. The anti-free radical activity is greatly improved.

Priority: FR2006-0052099 Applic. Date: 2006-06-12; WO2007-FR51405 Applic. Date: 2007-06-11

Inventor: ANDRE PATRICE (FR); RENIMEL ISABELLE (FR); GODENIR CELINE (FR); HOCQUAUX MICHEL (FR)

A1 Published: 2009-06-04

Title: Composition and its Therapeutic Use

Applicant: VERITRON LTD

Application No.: US2009-0367099 Applic. Date: 2009-02-06

Abstract: A composition having a variety of therapeutic and cosmetic uses comprises: (i) a vitamin; (ii) a metal salt that provides metal ions in vivo; and (iii) insulin or a growth hormone. Such a composition is useful for treating, for example, genetic disorders, skin diseases, cancer and viral infections.

Priority: US2009-0367099 Applic. Date: 2009-02-06; GB2002-0012405 Applic. Date: 2002-05-29; US2006-0534914 Applic. Date: 2006-09-25; US2003-0447770 Applic. Date: 2003-05-29; US2002-0407373P Applic. Date: 2002-08-30

Inventor: HAMID AL-SARI MISHAL (US); YOUNIS RAFEDA M A (AE); AL SARI KARAM M H (AE); AL SARI SAAD M H (AE); AL SARI AHMAD M H (AE)

A1 Published: 2009-06-04

Title: SALTS OF NATEGLINIDE

Application No.: US2009-0366936 Applic. Date: 2009-02-06

Abstract: The present invention relates to salts of organic acid, in particular salt of nateglinide, combined preparations comprising one or more salts of nateglinide and, optionally, one or more additional ingredients and the use thereof in pharmaceutical compositions for preventing or treating diabetes, cardiovascular disease, or conditions associated therewith.

Priority: US2009-0366936 Applic. Date: 2009-02-06; US2004-0507255 Applic. Date: 2004-09-28; WO2003-EP02447 Applic. Date: 2003-03-10; US2002-0363178P Applic. Date: 2002-03-11

Inventor: SUTTON PAUL ALLEN (US); VIVILECCHIA RICHARD V (US); PARKER DAVID JOHN (US); DE LA CRUZ MARILYN (US)

A1 Published: 2009-06-04

Title: Regulation of Mammalian Keratinous Tissue Using Skin and/or Hair Care Actives

Application No.: US2008-0271100 Applic. Date: 2008-11-14

Abstract: Personal care compositions containing an active selected from the group consisting of Boswellia serratta tree resins and gums, xymenynic acid, glycyrrhizinic acid in extract form, their salts, their derivatives, their precursors, and/or combinations thereof are provided. Methods for regulating the condition of mammalian keratinous tissue by topically applying the personal care compositions are also provided.

Priority: US2008-0271100 Applic. Date: 2008-11-14; US2007-0990940P Applic. Date: 2007-11-29

Inventor: MILLIKIN CHERI LYNN (US); BISSETT DONALD LYNN (US); GOODMAN LAURA JACKSON (US)

A1 Published: 2009-06-04

Title: Methods and Compositions for Enhancing the Viability Of Microneedle Pores

Applicant: ALLTRANZ INC (US)

Application No.: US2008-0325919 Applic. Date: 2008-12-01

Abstract: Described herein is a method of transdermally administering one or more pharmaceutically active agents to a mammal. The method comprises administering one or more active pharmaceutical agents to the skin of the subject, in conjunction with microneedles and one or more COX inhibitors, whereby the COX inhibitors facilitate the absorption of the active pharmaceutical agents by prolonging the pore opening created by the application of the microneedle.

Priority: US2008-0325919 Applic. Date: 2008-12-01; US2007-0990972P Applic. Date: 2007-11-29

Inventor: STINCHCOMB AUDRA LYNN (US); BANKS STAN LEE (US)

A1 Published: 2009-06-11

Title: SYNERGISTIC ACTIVE PREPARATIONS COMPRISING DIPHENYLMETHANE DERIVATIVES AND FURTHER SKIN AND/OR HAIR LIGHTENING AND/OR SENILE KERATOSIS REDUCING COMPOUNDS

Applicant: SYMRISE GMBH & CO KG (DE)

Application No.: US2007-0159951 Applic. Date: 2007-01-05

Abstract: The present invention relates to specific synergistic active skin- and/or hair-lightening and/or senile keratosis-reducing (cosmetic or pharmaceutical) preparations comprising a mixture comprising or consisting of a) a tyrosinase-inhibiting amount of one or more compounds of the formula 1: wherein: R1 is hydrogen, methyl, straight-chain or branched alkyl having 2-4 C atoms, OH or halogen, R2 is hydrogen, methyl or straight-chain or branched alkyl having 2-5 C atoms, R3 is methyl or straight-chain or branched alkyl having 2-5 C atoms, and R4 and R5 are, independently of one another hydrogen, methyl, straight-chain or branched alkyl having 2-5 C atoms, OH or halogen and b) a skin- and/or hair lightening and/or senile keratosis-reducing amount of one or more compounds selected from the group consisting of (i) chelating agents, (ii) phenolic derivatives,; plant extracts with an amount of phenolic derivatives and (iii) organic acid derivatives as well as uses thereof.

Priority: US2007-0159951 Applic. Date: 2007-01-05; US2006-0756205P Applic. Date: 2006-01-05; US2006-0804319P Applic. Date: 2006-06-09; WO2007-EP50124 Applic. Date: 2007-01-05

Inventor: SCHMAUS GERHARD (DE); LANGE SABINE (DE); VIELHABER GABRIELE (DE); SCHAPER KARIN (DE); PILLAI RAVIKUMAR (US)

A1 Published: 2009-06-11

Title: BIOMEDICAL FOAM ARTICLES

Applicant: BAYER INNOVATION GMBH (DE)

Application No.: US2008-0244236 Applic. Date: 2008-10-02

Abstract: The present invention relates to biomedical foam articles for the wound sector which are formed by spraying a polymeric dispersion onto a wound. The polymeric dispersion being sprayed onto a wound surface forms a three-dimensional body which conforms to the spatial shape of the wound and which, as well as covering the wound surface, ensures a complete and accurately fitted packing of the wound in the depth dimension as well as the other dimensions. The biomedical foam articles of the present invention are particularly useful for treating chronic wounds.

Priority: DE2007-10048080 Applic. Date: 2007-10-05

Inventor: FUGMANN BURKHARD (DE); DIETZE MELITA (DE); MAGER MICHAEL (DE); RISCHE THORSTEN (DE); HECKES MICHAEL (DE); RUDHARDT DANIEL (DE); GERTZMANN ROLF (DE); SCHONBERGER JAN (DE); DORR SEBASTIAN (DE)

A1 Published: 2009-06-11

Title: PROCESS FOR THE PREPARATION OF AROMATIZED CHEWING FOAMS FOR COSMETIC PRODUCTS

Applicant: BAYER MATERIALSCIENCE AG (DE)

Application No.: US2008-0253559 Applic. Date: 2008-10-17

Abstract: The invention relates to a process for the preparation of novel aromatized chewing foams for the oral care sector based on polyurethane-polyureas and aromatizing compositions

Priority: US2008-0253559 Applic. Date: 2008-10-17; US2007-0999611P Applic. Date: 2007-10-19

Inventor: HOFACKER STEFFEN (DE); NIESTEN MEIKE (DE); RISCHE THORSTEN (DE); DORR SEBASTIAN (DE); KRAMER THORSTEN (DE); SCHWANNECKE DIRK (US); ROHE GABRIELE (DE); HEPPERLE JENS (DE); KEMPKES HARTWIG (DE); LETMATHE CLAUDIA (DE)

A1 Published: 2009-06-11

Title: Compositions and methods for crystallizing antibodies

Application No.: US2008-0228038 Applic. Date: 2008-08-08

Abstract: The present invention relates to a batch crystallization method for crystallizing anti-human TNFalpha (hTNFalpha) antibody and antibody fragments which allows the production of said antibody on an industrial scale; a method of controlling the size of antibody crystals, for example, crystals of anti-hTNFalpha antibody fragments, compositions containing said crystals as well as methods of use of said crystals and compositions.

Priority: US2008-0228038 Applic. Date: 2008-08-08; US2007-0963964P Applic. Date: 2007-08-08

Inventor: FRAUNHOFER WOLFGANG (US); BORHANI DAVID W (US); WINTER GERHARD (DE); GOTTSCHALK STEFAN (DE)

A1 Published: 2009-06-11

Title: Cosmetic composition containing an extract from lotus and method of cosmetic care using said composition

Applicant: LVMH RECH (FR)

Application No.: US2008-0316144 Applic. Date: 2008-12-10

Abstract: The invention relates to a cosmetic composition containing at least one extract from at least one part of the Sacred Lotus plant (Nelumbo nucifera) in a cosmetically acceptable vehicle compatible with topical application on the skin, wherein said composition contains an aqueous extract of Sacred Lotus root and it additionally contains at least one active agent selected from the group comprising active agents with energizing or revitalizing activity, preferably diguanosine polyphosphate or an extract containing it, in particular an extract from Artemia salina; active agents stimulating the secretion of beta-endorphins, preferably an N-acetyl-Tyr-Arg-hexadecyl ester dipeptide; anti-radical agents such as tocopherol, in particular alpha-tocopherol in the form of a salt or a base, or one of its esters, for example tocopherol acetate, and plant extracts containing them as well as flavonoids and anthocyanins and plant extracts containing them, in particular extracts of Sacred Lotus flower and anti-inflammatory agents, in particular those having a phospholipase A2 inhibitory action, such as the ascorbyl tocopheryl phosphates, in particular potassium ascorbyl tocopheryl phosphate. It also relates to a method of cosmetic care quite particularly intended for the care of sensitive or reactive skin.

Priority: FR2007-0008590 Applic. Date: 2007-12-10; FR2008-0058318 Applic. Date: 2008-12-05

Inventor: ARCHAMBAULT JEAN-CHRISTOPHE (FR); FRANCHI JOCELYNE (FR); KORICHI RODOLPHE (FR)

A1 Published: 2009-06-11

Title: CHEMICAL COMPOSITION DERIVED FROM P-HYDROXYPHENYL PROPIONIC ACID FOR THE TREATMENT OF PSORIASIS

Applicant: APOTEKNOS PARA LA PIEL S L (ES)

Application No.: US2008-0332324 Applic. Date: 2008-12-10

Abstract: The present invention is a chemical composition including: Use of the compound with the chemical formula can be applied in pharmaceutical compositions for the treatment of psoriasis.

Priority: EP2007-0380346 Applic. Date: 2007-12-11

Inventor: PIVEL RANIERI JUAN PABLO (ES); FERRER CUESTA JUAN MANUEL (ES); MARTINEZ GALAN FERNANDO (ES); IRACHE JUAN MANUEL (ES); NOVELLA ROBISCO JOSE LUIS (ES); PEREZ RUEDA JUAN JOSE (ES); MARIA MARTIN MA PAZ (ES); ALVAREZ-BUILLA GOMEZ JULIO (ES); BERMEJO JAIME (ES); VIDAL VANACLOCHA FERNANDO (ES)

A1 Published: 2009-06-11

Title: WRINKLE REDUCTION AGENT, LIPOLYSIS ACCELERATOR, COMPOSITION FOR EXTERNAL USE ON SKIN, AND FOOD OR BEVERAGE COMPOSITION

Applicant: KAO CORP

Application No.: US2008-0335326 Applic. Date: 2008-12-15

Abstract: An antiwrinkle agent, lipolysis promoter, external composition for skin, and food and beverage composition having for an active ingredient thereof a compound represented by general formula (1): (wherein R represents a hydrogen atom or an acyl group having 2 to 20 carbon atoms) or an extract obtained from guinea ginger and/or an acylation treatment product of said extract.

Priority: JP2004-0250178 Applic. Date: 2004-08-30; US2008-0335326 Applic. Date: 2008-12-15; JP2005-0004506 Applic. Date: 2005-01-11; JP2004-0321698 Applic. Date: 2004-11-05; WO2005-JP15635 Applic. Date: 2005-08-29; US2007-0661401 Applic. Date: 2007-02-28; JP2005-0176165 Applic. Date: 2005-06-16; JP2005-0144765 Applic. Date: 2005-05-17

Inventor: SUGITA JUN (JP); IKEMOTO TAKESHI (JP); AKAZAWA YUMIKO (JP); KOBAYASHI YURIE (JP); MITANI MITSUMASA (JP); HARATAKE AKINORI (US); KOMIYA AYA (JP)

A1 Published: 2009-06-18

Title: ENHANCED PHOTOSTABILITY OF AVOBENZONE IN THE PRESENCE OF ZINC OXIDE USING PHOSPHATE-BASED EMULSIFIERS

Applicant: SCHERING PLOUGH HEALTHCARE

Application No.: US2007-0958907 Applic. Date: 2007-12-18

Abstract: The photostability of avobenzone in a sunscreen composition in the presence of zinc oxide is stabilized against photodegradation using phosphate-based emulsifiers.

Priority: US2007-0958907 Applic. Date: 2007-12-18

Inventor: MEYER THOMAS A (US); BEASLEY DONATHAN G (US)

A1 Published: 2009-06-18

Title: AGGREGATES WITH INCREASED DEFORMABILITY, COMPRISING AT LEAST THREE AMPHIPATS, FOR IMPROVED TRANSPORT THROUGH SEMI-PERMEABLE BARRIERS AND FOR THE NON-INVASIVE DRUG APPLICATION IN VIVO, ESPECIALLY THROUGH THE SKIN

Applicant: IDEA AG (DE)

Application No.: US2009-0356381 Applic. Date: 2009-01-20

Abstract: The invention describes combinations of at least three amphipatic substances forming aggregate suspensions in a polar liquid. Judicious choice of system components, which differ at least 2-times to 10-times in solubility, ensures said aggregates to have extended, unusually adaptable surfaces. This is probably due to simultaneous action on said aggregates of at least two more soluble substances amongst said three system components, at least one of which is an active ingredient and preferably a drug; the third component alternatively, can take the role of a drug. The patent further deals with the use of said combinations in pharmaceutical preparations capable of transporting drugs into the body of warm blood creatures.; This is made possible by the drug loading capability of said aggregates with the highly flexible and deformable coating, which renders the resulting drug carriers highly adaptable. The patent finally reveals suitable methods and favourable conditions for carrier manufacturing and application.

Priority: US2009-0356381 Applic. Date: 2009-01-20; US2003-0357618 Applic. Date: 2003-02-04; US2002-0417847P Applic. Date: 2002-10-11

Inventor: CEVC GREGOR (DE); VIERL ULRICH (DE)

A1 Published: 2009-06-18

Title: COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF AUTOIMMUNE CONDITIONS

Application No.: US2008-0044435 Applic. Date: 2008-03-07

Abstract: The methods include selectively reducing or expanding T cells according to the antigenic specificity of the T cells. Therefore, the present invention can be used to reduce or eliminate pathogenic T cells that recognize autoantigens, such as beta cell specific T cells. As such, the present invention can be used to prevent, treat or ameliorate autoimmune diseases such as IDDM. Furthermore, the present invention can be used to expand desirable T cells, such as anti-pathogenic T cells to prevent, treat and/or ameliorate autoimmune diseases.

Priority: US2008-0044435 Applic. Date: 2008-03-07; US2007-0893530P Applic. Date: 2007-03-07

Inventor: SANTAMARIA PEDRO (CA); MOORE ANNA (US)

A1 Published: 2009-06-18

Title: COSMETIC OR DEMOPHARMACEUTICAL COMPOSITION COMPRISING ENKEPHALIN-DERIVED PEPTIDES TO REDUCE AND/OR ELIMINATE FACIAL WRINKLES

Applicant: LIPOTEC SA (ES)

Application No.: US2006-0910719 Applic. Date: 2006-03-29

Abstract: The invention relates to a cosmetic or dermopharmaceutical composition comprising enkephalin-derived peptides for reducing and/or eliminating facial wrinkles. Said cosmetic or dermopharmaceutical composition for application in the skin, preferably in the skin of the face, to reduce and/or eliminate facial wrinkles, preferably facial expression wrinkles and comprises a cosmetically or dermopharmaceutically effective amount of a peptide of general formula (I). The invention also relates to the use of the peptide of general formula (I) in the preparation of a cosmetic or dermopharmaceutical composition reducing and/or eliminating facial wrinkles.

Priority: ES2005-0000824 Applic. Date: 2005-04-08; WO2006-ES00151 Applic. Date: 2006-03-29

Inventor: FERRER MONTIEL ANTONIO (ES); CEBRIAN PUCHE JUAN (ES); PUIG MONTIEL ARTURO (ES)

A1 Published: 2009-06-18

Title: Cosmetic Composition for Stimulating the Synthesis of Proteins of the Basement Membrane

Applicant: DSM IP ASSETS BV (NL)

Application No.: US2006-0226191 Applic. Date: 2006-04-28

Abstract: Cosmetic composition which can be applied topically, comprising at least one compound of the general formula (I) in which R1 is H, C1-C20-alkyl, cycloalkyl or aryl-C1-C4-alkyl, n is 1-4, X is -O-, -NH- or -NR2- and R2H or C1-C20-alkyl; and at least one compound corresponding to the above formula (I) but in which XR1 with X having the possible meaning of -NH- is the residue of an alpha-amino acid; use of these compounds and of the composition for stimulating the synthesis of the proteins of the basement membrane; and also both those compounds of the formula (I) in which X is -NR2- and both R1 and R2 are different from H, and the compounds corresponding to formula (I) but in which XR1 with X having the possible meaning of -NH- is the residue of an alpha-amino acid, as such.

Priority: WO2006-EP03998 Applic. Date: 2006-04-28

Inventor: ZIEGLER HUGO (CH); IMFELD DOMINIK (CH); STOCKLI MARTIN (CH); HEIDL MARC (DE)

A1 Published: 2009-06-18

Title: OSTEOINDUCTIVE MATERIALS

Applicant: BIOPH BIOTECH ENTW PHARM GMBH (DE)

Application No.: US2008-0336895 Applic. Date: 2008-12-17

Abstract: The present invention concerns improved osteoinductive materials comprising matrix materials and morphogenetic roteins, wherein depending on the subject matter the proteins may be dimeric or monomeric proteins. The osteoinductive materials according to the present invention have improved properties. The invention further concerns methods for producing the respective improved osteoinductive materials.

Priority: US2008-0336895 Applic. Date: 2008-12-17; EP2003-0007141 Applic. Date: 2003-03-28; US2005-0550958 Applic. Date: 2005-09-28; WO2004-EP03238 Applic. Date: 2004-03-26

Inventor: POHL JENS (DE); BECHTOLD ROLF (DE); KRUSE MICHAEL (DE)

A1 Published: 2009-06-18

Title: PRODUCTION OF HUMAN DEFENSINS IN PLANT CELLS

Application No.: US2006-0096860 Applic. Date: 2006-12-14

Abstract: The present invention relates, generally, to the production of human defensins from plant cells. Heterologous DNA comprising genes encoding one or more desired human defensins are introduced into plant cells. The one or more human defensins can be recombinantly-produced in the plant cells, purified from the plant cells, and used as an anti-infective agent, a wound treatment agent, a skin care agent, or an agent in the treatment of various intestinal diseases, including irritable bowel disease (IBD), ulcerative colitis, and Crohn's disease. The recombinantly-produced alpha-defensins can be provided as oral and topical formulations.

Priority: US2006-0096860 Applic. Date: 2006-12-14; US2005-0750375P Applic. Date: 2005-12-15; WO2006-US47606 Applic. Date: 2006-12-14

Inventor: HUANG NING (US); ZHANG DESHUI (US)

A1 Published: 2009-06-18

Title: Cell permeable conjugates of peptides for inhibition of protein kinases

Applicant: CUREGENICS LTD

Application No.: US2008-0229398 Applic. Date: 2008-08-22

Abstract: The present invention provides inhibitors of protein kinases comprising a molecule having at least a first moiety competent for penetration of the molecule into cells, and a second moiety for having a protein kinase inhibiting effect within the cells. The first moiety is joined to the second moiety through a linker or a spacer. The complex molecules are preferably peptide conjugates having improved cell-permeability, serum stability and kinase selectivity compared to known protein kinase inhibitors. Pharmaceutical compositions that include these protein kinase inhibitors, and methods of using such compositions for treatment of cancers and other diseases associated with protein kinase activity are also disclosed.

Priority: US2008-0229398 Applic. Date: 2008-08-22; IL2003-0156429 Applic. Date: 2003-06-12; US2005-0295793 Applic. Date: 2005-12-06; WO2004-IL00505 Applic. Date: 2004-06-13

Inventor: LIVNAH NARIT (IL); LEVITZKI ALEXANDER (IL); SENDEROVITZ HANOCH (IL); YECHEZKEL TAMAR (IL); SALITRA YOSEF (IL); LITMAN PNINIT (IL); OHNE OSNAT (IL)

A1 Published: 2009-06-18

Title: Substituted Phosphate Esters of Nucleoside Phosphonates

Application No.: US2006-0887501 Applic. Date: 2006-03-30

Abstract: Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections and/or cell proliferation. The compounds provided herein are obtained by attaching the phosphonate nucleoside of interest to alkyloxyalkyl-phosphate or alkyl-phosphate in a phosphate-phosphono anhydride linkage to provide a modified nucleoside phosphonate drug.

Priority: US2006-0887501 Applic. Date: 2006-03-30; US2005-0667739P Applic. Date: 2005-04-01; WO2006-US12121 Applic. Date: 2006-03-30

Inventor: HOSTETLER KARL Y (US); BEADLE JAMES R (US); RUIZ JACQUELINE C (US)

A1 Published: 2009-06-18

Title: KINASE INHIBITORS

Applicant: TAKEDA SAN DIEGO INC (US)

Application No.: US2008-0103625 Applic. Date: 2008-04-15

Abstract: Compounds are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Priority: US2008-0103625 Applic. Date: 2008-04-15; US2007-0912625P Applic. Date: 2007-04-18

Inventor: BROWN JASON W (US); DONG QING (US); PARASELLI BHEEMA R (US); STAFFORD JEFFREY A (US); GONG XIANCHANG (US); LIU YAN (US); SCORAH NICHOLAS (US); WALLACE MICHAEL B (US)

A1 Published: 2009-06-18

Title: Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine H4 receptor

Application No.: US2008-0316835 Applic. Date: 2008-12-16

Abstract: Bicyclic heteroaryl-substituted imidazole compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.

Priority: US2008-0316835 Applic. Date: 2008-12-16; US2007-0014572P Applic. Date: 2007-12-18

Inventor: KINDRACHUK DAVID E (US); VENABLE JENNIFER D (US)

A1 Published: 2009-06-18

Title: Cellular phosphorylation potential enhancing compositions preparation and use thereof

Application No.: US2008-0222237 Applic. Date: 2008-08-04

Abstract: A pharmaceutical composition comprising as an active phosphorylation potential enhancing substance a pharmaceutically-acceptable salt of an alpha-keto carboxylic acid thereof alone or in combination with nicatinamide and creatine and, its use and products containing the same.

Priority: US2008-0222237 Applic. Date: 2008-08-04; US2008-0082697 Applic. Date: 2008-04-11; US2003-0643080 Applic. Date: 2003-08-19; US2001-0828589 Applic. Date: 2001-04-09; US2000-0550047 Applic. Date: 2000-04-14; US1997-0999767 Applic. Date: 1997-10-27; US1996-0643284 Applic. Date: 1996-05-08; US1996-0646572 Applic. Date: 1996-05-08; US1994-0239635 Applic. Date: 1994-05-09

Inventor: BUNQER ROLF (US)

A1 Published: 2009-06-18

Title: Transdermal treatment device and method

Application No.: US2008-0231798 Applic. Date: 2008-09-05

Abstract: A treatment device for treating a medical condition comprises a composition selected for its ability to treat the medical condition, the composition being formulated for transdermal delivery. A portable container is provided which comprises a body for accommodating the composition in a sealed arrangement, a frangible seal on the container which can be ruptured to enable discharge of the composition from the body, and an application component on the container for facilitating transdermal delivery of the composition.

Priority: US2008-0231798 Applic. Date: 2008-09-05; US2007-0967766P Applic. Date: 2007-09-06

Inventor: PETRIE AREZOU (US); PETRIE LOUIS (US); ROY XAVIER (US)

A1 Published: 2009-06-25

Title: Microemulsion and Shaving Apparatus Comprising a Microemulsion

Application No.: US2006-0083470 Applic. Date: 2006-10-16

Abstract: A microemulsion comprising an oil phase, an aqueous phase, a surfactant, and a hair modification active. The microemulsion is suitable for being impregnated therein or deposited thereon a substrate.

Priority: GB2005-0020931 Applic. Date: 2005-10-14; WO2006-GB03814 Applic. Date: 2006-10-16

Inventor: ACHER DAVID (GB); ELLIS PAUL (GB); HEESON TRACEY (GB)

A1 Published: 2009-06-25

Title: COMPOSITIONS AND METHODS FOR TREATING SKIN CONDITIONS IN MAMMALS

Application No.: US2007-0961333 Applic. Date: 2007-12-20

Abstract: A topical composition for treating skin diseases is provided. The composition comprises calendula, tea tree oil, eucalyptus oil, grape seed oil, and Aloe vera. In some embodiment, the composition may also include beeswax, vegetable oil, vitamin E, rosemary oil, or shea butter or combinations thereof to further enhance its beneficial effects. In some embodiments, the composition may also include herbs. Kits and methods for treatment of skin diseases are also disclosed.

Priority: US2007-0961333 Applic. Date: 2007-12-20

Inventor: DILEVA ROSE MARIE (US)

A1 Published: 2009-06-25

Title: FORMULATIONS OF LOW OIL CONTENT COMPRISING DIPHENYLMETHANE DERIVATIVES

Applicant: SYMRISE GMBH & CO KG (DE)

Application No.: US2007-0159886 Applic. Date: 2007-01-05

Abstract: The present invention relates to specific (cosmetic) formulations for improving the bioavailability and activity of skin- or hair-lightening or senile keratosis-reducing diphenylmethane derivatives (tyrosinase inhibitors) of the following formula 1:

Priority: US2007-0159886 Applic. Date: 2007-01-05; US2006-0756205P Applic. Date: 2006-01-05; WO2007-EP50125 Applic. Date: 2007-01-05

Inventor: VIELHABER GABRIELE (DE); SCHMAUS GERHARD (DE); LANGE SABINE (DE); SCHAPER KARIN (DE)

A1 Published: 2009-06-25

Title: MELATONIN AND IMMUNOSTIMULATING SUBSTANCE-BASED COMPOSITIONS

Applicant: MAVI SUD S R L (IT)

Application No.: US2007-0281523 Applic. Date: 2007-03-02

Abstract: The present invention relates to synergistic associations of melatonin and other active substances and cosmetic compositions suitable for treating all those manifestations causing or accompanying the aging of skin, hair and other tissues. In particular, the invention is based on the use of melatonin associated with immunoactive and antioxidant substances significantly potentiating its antiaging activity, remarkably reducing free radical formation and thereby improving the aspect of both skin and hair.

Priority: IT2006-RM00108 Applic. Date: 2006-03-03; WO2007-EP52026 Applic. Date: 2007-03-02

Inventor: MORGANTI PIERFRANCESCO (IT)

A1 Published: 2009-06-25

Title: Modified self-assembling peptides

Applicant: MASSACHUSETTS INST TECHNOLOGY

Application No.: US2007-0904278 Applic. Date: 2007-09-26

Abstract: The present invention provides a self-assembling peptide comprising: (a) a first amino acid domain that mediates self-assembly, wherein the domain comprises alternating hydrophobic and hydrophilic amino acids that are complementary and structurally compatible and self-assemble into a macroscopic structure when present in unmodified form; and (b) a second amino acid domain that does not mediate self-assembly in isolated form, wherein the second amino acid domain comprises at least one minimal biologically active sequence. Such self-assembling peptides are described herein as "modified self-assembling peptides." The present invention also provides pharmaceutical compositions, kits and matrices comprising a modified self-assembling peptide, and methods of using and making such compositions, kits and matrices.

Priority: US2007-0904278 Applic. Date: 2007-09-26; US2006-0847303P Applic. Date: 2006-09-26

Inventor: HORII AKIHIRO (JP); ZHANG SHUGUANG (US); WANG XIUMEI (CN); GELAIN FABRIZIO (IT)

A1 Published: 2009-06-25

Title: METHODS AND COMPOSITIONS FOR ANTAGONIZING ANTI-APOPTOTIC Bcl-2-FAMILY PROTEINS

Applicant: BURNHAM INST MEDICAL RESEARCH (US)

Application No.: US2008-0325315 Applic. Date: 2008-12-01

Abstract: The cytotoxic natural product gambogic acid (GA) competes for BH3 peptide binding sites on several anti-apoptotic members of the Bcl-2 family of proteins and neutralizes the ability of these proteins to suppress release of apoptogenic proteins from isolated mitochondria. Structure-function analysis of GA using analogs suggested a general correlation between BH3 competition and cytoxicity activity. Compositions and methods are provided for using GA and its derivatives for treating cancer and for discovering other compounds that are useful for treating cancer through their interaction with Bcl-2-family proteins.

Priority: US2008-0325315 Applic. Date: 2008-12-01; US2007-0005303P Applic. Date: 2007-12-03

Inventor: REED JOHN C (US); ZHAI DAYONG (US)

A1 Published: 2009-06-25

Title: SILICONE CONTAINING POLYMERIC MATERIALS

Applicant: ADVANCED MEDICAL OPTICS INC (US)

Application No.: US2007-0963351 Applic. Date: 2007-12-21

Abstract: A polymeric material with a variable modulus of elasticity is described herein. The polymeric material described herein is useful for forming implantable medical devices (e.g. ophthalmic lenses, breast implants, and body augmentation devices). In addition, medical devices formed from the polymer material can be used to controllably release a therapeutic agent. Also, the polymeric material may be used to prepare topical compositions or other applications or devices where control of a mechanical property such as material modulus is important.

Priority: US2007-0963351 Applic. Date: 2007-12-21

Inventor: HU CAN B (US); MAI THUY B (US)

A1 Published: 2009-07-02

Title: Method of de-wrinkling garments and device for facilitating same

Application No.: US2008-0317717 Applic. Date: 2008-12-22

Abstract: A device and process for conveniently removing wrinkles from dried clothes. The inventive device includes an outer shell enclosing a core of water absorbent material. The device may be spherical, cubic, or be in other regular or irregular geometric shapes, having a finish that would not damage or affect the tumbling of clothes in the dryer. The foam material in the shell is saturated with water prior to tossing into the clothes dryer with the clothes to be de-wrinkled. Moisture from the foam material in the shell is introduced into the dryer chamber from the dryer heat, which relaxes wrinkles on clothing.

Priority: US2008-0317717 Applic. Date: 2008-12-22; US2007-0008760P Applic. Date: 2007-12-21

Inventor: NEKOVAR JACQUELYN (US)

A1 Published: 2009-07-02

Title: METHODS AND COMPOSITIONS FOR TREATING IMMUNE DISORDERS

Applicant: CANCER REC TECH LTD (GB)

Application No.: US2006-0088752 Applic. Date: 2006-10-12

Abstract: The present invention provides oligonucleotides, compositions comprising them and methods that use the oligonucleotides and compositions for stimulating cells expressing the TLR7 and/or TLR8 receptor. The oligonucleotides comprise for stimulating TLR7 comprise uracil-rich regions. The oligonucleotides for stimulating TLR8 comprise guanine-rich regions. The present methods and compositions are useful, inter alia, for treating or preventing conditions such as infectious disease and cancer.

Priority: US2006-0088752 Applic. Date: 2006-10-12; US2005-0726305P Applic. Date: 2005-10-12; US2005-0751917P Applic. Date: 2005-12-20; WO2006-EP67334 Applic. Date: 2006-10-12

Inventor: DIEBOLD SANDRA (GB); REIS E SOUSA CAETANO (GB); PATUREL CARINE (FR)

A1 Published: 2009-07-02

Title: BIOMEDICAL FOAM ARTICLES

Applicant: BAYER BUSINESS SERVICES GMBH (DE)

Application No.: US2007-0296380 Applic. Date: 2007-04-05

Abstract: The present invention relates to biomedical foam articles for the wound sector which are formed by spraying a polymeric dispersion onto a wound. The polymeric dispersion being sprayed onto a wound surface forms a three-dimensional body which conforms to the spatial shape of the wound and which, as well as covering the wound surface, ensures a complete and accurately fitted packing of the wound in the depth dimension as well as the other dimensions. The biomedical foam articles of the present invention are particularly useful for treating chronic wounds.

Priority: DE2006-10016636 Applic. Date: 2006-04-08; WO2007-EP03077 Applic. Date: 2007-04-05

Inventor: DIETZE MELITA (DE); FUGMANN BURKHARD (DE); MAGER MICHAEL (DE); RISCHE THORSTEN (DE); HECKES MICHAEL (DE); RUDHARDT DANIEL (DE); GERTZMANN ROLF (DE)

A1 Published: 2009-07-02

Title: Essential Oil Diffusion

Application No.: US2008-0345556 Applic. Date: 2008-12-29

Abstract: A method for treating and/or alleviating at least one symptom associated with impaired airway clearance of mucous, impaired oxygen intake, and/or infection in a patient suffering from a respiratory ailment and/or restrictive lung disease includes administering to the patient an effective amount of an essential oil composition including at least one essential oil selected from Lavandula latifolia (spike lavender), Thymus mastichina (Spanish marjoram); Abies balsamea (balsam fir); and Menthaxpiperita (peppermint). The symptoms associated with impaired airway clearance, impaired oxygen intake, and/or infection can be alleviated via passive or active inhalation of the essential oil composition.

Priority: US2008-0345556 Applic. Date: 2008-12-29; US2007-0017508P Applic. Date: 2007-12-28

Inventor: HEDAYAT KAMYAR MALEK (US)

A1 Published: 2009-07-02

Title: Peptides Having Activities of Insulin Like Growth Factor-1 and their Uses

Applicant: CAREGEN CO LTD (KR)

Application No.: US2007-0224788 Applic. Date: 2007-03-06

Abstract: The present invention relates to a peptide having the activity of insulin like growth factor-1 (IGF-1) and derived from IGF-1, a composition for improving skin conditions or treating a periodontal disease comprising the peptide. The IGF-1 mimicking peptides of this invention have identical functions or actions to natural-occurring IGF-1 and much better stability and skin permeation than natural-occurring IGF-1. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on the treatment, prevention and improvement of diseases or conditions demanding IGF-1 activities. In addition, the peptides of this invention can be advantageously applied to pharmaceutical compositions, quasi-drugs and cosmetics.

Priority: KR2006-0021099 Applic. Date: 2006-03-06; WO2007-KR01086 Applic. Date: 2007-03-06

Inventor: CHUNG YONG JI (KR); KIM YOUNG DEUG (KR); KIM EUN MI (KR)

A1 Published: 2009-07-02

Title: PERSONAL CARE COMPOSITIONS

Applicant: DU PONT (US)

Application No.: US2009-0400309 Applic. Date: 2009-03-09

Abstract: This invention relates to personal care compositions containing polytrimethylene ether glycol in a variety of physical forms including solutions, gels, oil-in-water emulsions, water-in-oil emulsions, suspensions and solids. In a particularly preferred embodiment, the polytrimethylene ether glycol is derived predominantly from monomers obtained from renewable resources, making the personal care products of this embodiment of the present invention more environmentally friendly in terms of their manufacture, use and disposal.

Priority: US2009-0400309 Applic. Date: 2009-03-09; US2007-0801872 Applic. Date: 2007-05-11; US2006-0801166P Applic. Date: 2006-05-17

Inventor: SUNKARA HARI BABU (US)

A1 Published: 2009-07-02

Title: Compounds, Pharmaceutical Compositions and Therapeutic Methods of Preventing and Treating Diseases and Disorders Associated With Amyloid Fibril Formation

Applicant: YISSUM RES DEV CO (IL)

Application No.: US2005-0585695 Applic. Date: 2005-01-09

Abstract: Compounds, pharmaceutical compositions and methods for prevention and/or reversal of amyloid fibril formation and treating amyloid-related disorders are provided. Also provided a method of limiting and/or reducing inflammation.

Priority: WO2005-IL00028 Applic. Date: 2005-01-09; US2004-0535203P Applic. Date: 2004-01-09

Inventor: SOREQ HERMONA (IL); DIAMANT SOPHIE (IL)

A1 Published: 2009-07-02

Title: HSC SELF-RENEWAL

Application No.: US2008-0268320 Applic. Date: 2008-11-10

Abstract: The invention is related to methods for culturing stem cells, more particularly hematopoietic stem cells (HSC). The invention relates to methods for HSC expansion and the use of RASSF8 to increase the retention and/or expansion of KLS cells in vitro. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other things, for treatment of disorders or diseases (e.g. leukemia). The invention also relates to the development of small molecules that may increase HSC self renewal in vitro and in vivo.

Priority: US2008-0268320 Applic. Date: 2008-11-10; US2006-0452081 Applic. Date: 2006-06-13; US2005-0690089P Applic. Date: 2005-06-13

Inventor: VERFAILLIE CATHERINE (BE); SCHOEMANS HELENE (BE); SNOECKX RIKKERT (BE)

A1 Published: 2009-07-02

Title: Compositions Containing Proteins for the Transfer/Recycling of Structurally Modified Lipids, and the Applications Thereof

Applicant: MERZ PHARMA GMBH & CO KGAA

Application No.: US2006-0085095 Applic. Date: 2006-10-24

Abstract: The invention relates to compositions containing recycling/transfer proteins for structurally/functionally modified lipids, a lipid depot of structurally non-modified lipids, and non-transferable active ingredients. Such compositions can be used for the engineering of biomembranes, e.g. by external topical application, especially to the skin/mucous membranes. Structurally or functionally, especially oxidatively modified, lipids are removed from the structures containing the same, such as lipid aggregates of the skin, are externally regenerated in a depot, and preferably introduced back into the structures. The invention also relates to the recycling of modified lipids of biomembranes. The inventive compositions are self-regulative and can be especially applied in a cosmetic, cosmetic balneological or dermatological/pharmaceutical manner.

Priority: DE2005-10056538 Applic. Date: 2005-11-28; WO2006-EP10223 Applic. Date: 2006-10-24

Inventor: BEUTLER ROLF D (DE); SCHMIDT KARLHEINZ (DE)

A1 Published: 2009-07-02

Title: Pharmaceutical Compositions Comprising Cyclosporin

Applicant: PARI PHARMA GMBH (DE)

Application No.: US2006-0086141 Applic. Date: 2006-11-29

Abstract: The invention relates to liquid pharmaceutical compositions containing: a) a therapeutically effective dose of a cyclosporin; b) an aqueous carrier liquid; c) a first solubilizing substance selected among the group of phospholipids; and d) a second solubilizing substance selected among the group of non-ionic surfactants. Preferably, the cyclosporin is liposome solubilized. The inventive composition is suitable for oral, parenteral, nasal, mucosal, topical, and particularly pulmonary application in the form of an aerosol.

Priority: DE2005-10058252 Applic. Date: 2005-12-06; DE2006-10051512 Applic. Date: 2006-10-31; WO2006-EP11459 Applic. Date: 2006-11-29

Inventor: KELLER MANFRED (DE); AKKAR ASLIHAN (DE)

A1 Published: 2009-07-02

Title: TOPICALLY APPLICABLE COMPOSITION FOR USE AS A SKIN BLEACHING AGENT

Applicant: DSM IP ASSETS BV (NL)

Application No.: US2006-0089654 Applic. Date: 2006-10-09

Abstract: Topical composition for use especially as a skin lightener, characterized in that it contains an effective amount of at least one compound of general formula (I) or a mixture of such compounds and/or an acid addition salt thereof: in which X is NH or a direct bond and n is 2, 3 or 4, preferably 2 or 3, and its use for lightening skin colour, for depigmenting liver spots and for evening out non-uniformities in skin colouration. The invention further relates to dermatologically effective compositions containing at least one disulfide of general formula (I) and at least one additional skin care ingredient.

Priority: CH2005-0001656 Applic. Date: 2005-10-12; WO2006-CH00555 Applic. Date: 2006-10-09

Inventor: ZIEGLER HUGO (CH); WIKSTROEM PETER (CH); STOCKLI MARTIN (CH)

A1 Published: 2009-07-02

Title: PQS AND ITS CONJUGATES AS ADJUVANTS AND THEIR USES IN PHARMACEUTICAL COMPOSITIONS

Applicant: HELMHOLTZ ZENTRUM FUR INFEKTIO (DE)

Application No.: US2006-0092518 Applic. Date: 2006-11-08

Abstract: The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new compounds useful as adjuvants and/or immunomodulators for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumours, allergies as well as for the control of fertility in human or animal populations. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants. In addition, the invention relates to its uses as active ingredients in pharmaceutical compositions.

Priority: EP2005-0024266 Applic. Date: 2005-11-08; WO2006-EP10699 Applic. Date: 2006-11-08

Inventor: EBENSEN THOMAS (DE); MORR MICHAEL (DE); GUZMAN CARLOS A (DE)

A1 Published: 2009-07-02

Title: Use of ginsenosides and extracts containing them

Application No.: US2008-0291782 Applic. Date: 2008-11-13

Abstract: The present invention relates to the use of ginsenosides and a plant extract containing ginsenosides in a cosmetic or pharmaceutical composition or in a food supplement for the protection of the skin against deleterious effects of stress or irradiation e.g. sunlight or UV irradiation.

Priority: EP2006-0290814 Applic. Date: 2006-05-17

Inventor: SENE GERARD (FR); LOISEAU ALAIN (FR); MEYBECK ALAIN (FR); YANG CHONG REN (CN)

A1 Published: 2009-07-02

Title: Personal Care Compositions

Application No.: US2008-0274865 Applic. Date: 2008-11-20

Abstract: Personal care compositions comprising an active component, use of such compositions, and methods of marketing such compositions. The personal care compositions can be applied topically, ingested orally, injected, or used as part of a regimen.

Priority: US2008-0274865 Applic. Date: 2008-11-20; US2007-0991005P Applic. Date: 2007-11-29

Inventor: OSBORNE ROSEMARIE (US)

A1 Published: 2009-07-02

Title: NOVEL USE OF 1, 2, 3, 4, 6-PENTA-O-GALLOYL-BETA-D-GLUCOSE

Application No.: US2007-0161164 Applic. Date: 2007-01-16

Abstract: The present invention relates to novel use of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose. More particularly, the present invention relates to a pharmaceutical composition and cosmetic composition for preventing and treating skin disease, comprising 1,2,3,4,6-penta-O-galloyl-beta-D-glucose represented by formula 1 as an active ingredient. Also, the invention relates to a method for preventing and treating skin disease using 1,2,3,4,6-penta-O-galloyl-beta-D-glucose, and to the use of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose.

Priority: KR2006-0004403 Applic. Date: 2006-01-16; WO2007-KR00266 Applic. Date: 2007-01-16

Inventor: SHIN DONG-HEON (KR)

A1 Published: 2009-07-02

Title: Acid Mimic Compounds for the Inhibition of Isoprenyl-S-Cysteinyl Methyltransferase

Application No.: US2008-0326746 Applic. Date: 2008-12-02

Abstract: Among other things, the present invention provides novel compounds capable of effectively inhibiting inflammatory responses that are mediated by G-proteins or GPCRs in neutrophils, macrophages and platelets. In particular, compounds of the present invention act as inhibitors of edema, inhibitors of erythema and inhibitors of MPO (myeloperoxidase), pharmaceutical compositions containing the same compounds and the use thereof for the treatment of diseases that may benefit from edema, erythema and MPO inhibition, such as inflammation (acute or chronic), asthma, autoimmune diseases, and chronic obstructive pulmonary disease (COPD) (e.g., emphysema, chronic bronchitis and small airways disease, etc.), inflammatory responses of the immune system, skin diseases (e.g., reducing acute skin irritation for patients suffering from rosacea, atopic dermatitis, seborrheic dermatitis, psoriasis),; irritable bowel syndrome (e.g., Chron's disease and ulcerative colitis, etc.), and central nervous system disorders (e.g., Parkinson's disease).

Priority: US2008-0326746 Applic. Date: 2008-12-02; US2007-0005129P Applic. Date: 2007-12-03; US2007-0005866P Applic. Date: 2007-12-07; US2007-0007234P Applic. Date: 2007-12-10

Inventor: LEE SEUNG-YUB (US); PEREZ EDUARDO (US); RAPOLE KESHAVA (US); SARNGADHARAN GOPAL (US); STOCK GREGORY B (US); STOCK JEFFRY B (US); STOCK MAXWELL (US); VORONKOV MICHAEL (US); WOLANIN PETER (US)

A1 Published: 2009-07-09

Title: Merchandising Systems, Methods of Merchandising, and Point-Of-Sale Devices Comprising Micro-Optics Technology

Applicant: NANOVENTIONS HOLDINGS LLC (US)

Application No.: US2008-0969625 Applic. Date: 2008-01-04

Abstract: A merchandising system, including: a consumer product. The merchandising system includes at least one of the consumer product, packaging for the consumer product, and advertisement material pertaining to the consumer product. At least one element of the merchandising system includes indicia and/or an image that relates, or is analogous to, an attribute and/or targeted benefit of the consumer product. At least one element of the merchandising system further includes a micro-optic structure capable of controlling the scatter of light impinging thereon so that the micro-optic structure reflects and/or transmits light in a field of view over which at least a portion of the indicia and/or image appears brighter relative to that outside the field of view.

Priority: US2008-0969625 Applic. Date: 2008-01-04

Inventor: STEENBLIK RICHARD A (US); HURT MARK J (US); JORDAN GREGORY R (US); MARTIN BRIAN S (US); SUSONG JENNIFER (US)

A1 Published: 2009-07-09

Title: Merchandising Systems, Methods of Merchandising, and Point-Of-Sale Devices Comprising Micro-Optics Technology

Applicant: NANOVENTIONS HOLDINGS LLC (US)

Application No.: US2008-0969614 Applic. Date: 2008-01-04

Abstract: A merchandising system, including: a consumer product. The merchandising system includes at least one of the consumer product, packaging for the consumer product, and advertisement material pertaining to the consumer product. At least one element of the merchandising system includes indicia and/or an image that relates, or is analogous to, an attribute and/or targeted benefit of the consumer product. At least one element of the merchandising system further includes a micro-optic structure capable of controlling the scatter of light impinging thereon so that the micro-optic structure reflects and/or transmits light in a field of view over which at least a portion of the indicia and/or image appears brighter relative to that outside the field of view.

Priority: US2008-0969614 Applic. Date: 2008-01-04

Inventor: STEENBLIK RICHARD A (US); HURT MARK J (US); JORDAN GREGORY R (US); MARTIN BRIAN S (US); SUSONG JENNIFER (US)

A1 Published: 2009-07-09
Patent No.: US7631766B2 Issued: 2009-12-15

Title: COSMETIC MASK PACKAGE

Application No.: US2008-0107942 Applic. Date: 2008-04-23

Abstract: A cosmetic mask package has an outer pouch, a liquid storing device and a carrier. The outer pouch has an interior surface defining an inner space. The liquid storing device is mounted in the inner space inside the outer pouch and has an inner pouch filled with liquid and a pointed instrument selectively piercing the inner pouch to release the liquid. The carrier is dry to prevent microorganism growth and is mounted in the inner space inside the outer pouch and outside the inner pouch. When the inner pouch is pierced, the carrier is moistened for use. Additional preservatives are not required so the masks are hypoallergenic and hygienic.

Priority: TW2008-0200405U Applic. Date: 2008-01-08

Inventor: WANG CHU-HUI (TW)