Title: Acid-sensitive compounds, their preparation and uses

Applicant/Assignee: GENCELL S.A GENCELL, S.A

Application No.: 11/054612   Filing Date: 10/Feb/2005

Abstract:

Novel acid-sensitive compounds comprising a cyclic ortho-ester that is acid-sensitive, and their salts, and comprising at least one hydrophilic substituent. These compounds are useful, for example, for forming conjugates (liposomes, complexes, nanoparticles and the like) with biologically active substances and releasing them into cellular tissues or compartments whose pH is acidic, or as nonionic surfactant for stabilizing particles encapsulating a biologically active substance and then destabilizing them in acid medium, or alternatively as a vector covalently linked to a therapeutic molecule so as to release said therapeutic molecule into the cellular tissues or compartments whose pH is acidic.

Priority: US2001-972854 Applic. Date: 2001-10-10; US20000239116P Applic. Date: 2000-10-11

Inventor: BESSODES MICHEL [FR]; MASSON CHRISTOPHE [FR]; SCHERMAN DANIEL [FR]; WETZER BARBARA [FR]

Title: Detergent composition containing a cationised silicone delivery system

Applicant/Assignee: CONOPCO, INC

Application No.: 10/543473   Filing Date: 23/Jan/2004

Abstract:

A cleansing cosmetic composition comprising

i) a cationized silicon delivery system selected from one or more of a) a cationized fatty alkyl silicone copolymer

b) a cationized dimethiconol complex and c) a cationized high viscosity lower alkyl silicone fluid with or without cationized silicone gum blend

and ii) detergent active. Also disclosed is a cationized silicone delivery system comprising: a) 15-50 parts of a cationized fatty alkyl silicone copolymer

b) 5-50 parts of a cationized dimethiconol complex

and c) 1-50 parts of a cationized high viscosity lower alkyl silicone fluid with cationized silicone gum blend.

Priority: IN2003MU00108 Applic. Date: 2003-01-29; IN2003MU00109 Applic. Date: 2003-01-29; GB20030009017 Applic. Date: 2003-04-22; GB20030010786 Applic. Date: 2003-05-12; WO2004EP00662 Applic. Date: 2004-01-23

Inventor: PAUL SUDIPTO KUMAR [IN]; RAMACHANDRAN KIZHAKERA NAIRVEETIL [IN]

Title: Topical application of adapalene for the long-term treatment of acne vulgaris

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT

Application No.: 11/878736   Filing Date: 26/Jul/2007

Abstract:

Administration of adapalene in a topical medicament to a patient so as to sustain its biological response in the treatment of acne vulgaris, wherein the administration pattern of the topical medicament comprises topically applying onto the afflicted skin area a therapeutically effective amount of adapalene at least once every two days for at least 6 months.

Priority: WO2006EP01140 Applic. Date: 2006-01-23; US20050647306P Applic. Date: 2005-01-26

Inventor: GRAEBER MICHAEL [US]

Title: Absorbent articles comprising a bodily exudate modifying agent and a skin care formulation

Applicant/Assignee: KIMBERLY-CLARK WORLDWIDE, INC

Application No.: 10/915642   Filing Date: 10/Aug/2004

Abstract:

Absorbent articles having enhanced absorption of bodily exudates are disclosed. The absorbent articles comprise a bodily exudate modifying agent and a skin care formulation. The bodily exudate modifying agent is capable of reducing the viscosity of bodily exudates such as feces and menses. The skin care formulation comprises a bodily exudate modifying agent neutralizer to neutralize the possible negative effects on skin barrier function caused by the bodily exudate modifying agents coming into direct contact with the wearer's skin.

Priority:

Inventor: COHEN JASON C [US]; KOENIG DAVID W [US]; BROCK EARL DAVID [US]; BARATIAN STEPHEN A [US]; CUNNINGHAM COREY [US]; BALDWIN STEPHEN [US]

Title: Body or plant part dressing

Applicant/Assignee:

Application No.: 11/434689   Filing Date: 16/May/2006

Abstract:

A dressing having a flexible sleeve shaped to accommodate a substantially cylindrical body or plant portion, the sleeve having a lining which is substantially non-adherent to the body or plant part being bandaged and having a peripheral securement means which attaches two peripheral portions to each other without those portions being circumferentially adhered to the sleeve portion.

Priority:

Inventor: JENNINGS-SPRING BARBARA BROOKE [US]

Title: Peptide sequence found in Laminin 5 for treating skin impairments

Applicant/Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS LABORATOIRES D'ANJOU CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

Application No.: 11/572774   Filing Date: 29/Jul/2005

Abstract:

Peptide of sequence TALRIRATYGEY (SEQ ID NO: 1) present on the gamma 2 chain of Laminin 5, a pharmaceutical composition containing the peptide and to the use of the composition for treating various skin alterations. More particularly, the treatment of the alterations includes reinforcing the derma-epidermal junction and the cell-matrix and/or cell-cell adherence of epidermis and in promoting the repair of a cutaneous surface.

Priority: FR20040008383 Applic. Date: 2004-07-29; WO2005FR01999 Applic. Date: 2005-07-29

Inventor: ROUSSELLE PATRICIA [FR]

Title: Saccharide foamable compositions

Applicant/Assignee: FOAMIX LTD

Application No.: 11/430437   Filing Date: 09/May/2006

Abstract:

A foamable composition, containing a saccharide for use in the treatment of various disorders including: water, a saccharide, about 0.2% to about 5% by weight of a surface-active agent, about 0.01% to about 5% by weight of at least one polymeric agent selected from a bio-adhesive agent, a gelling agent, a film forming agent and a phase change agent, and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.

Priority: US20050679020P Applic. Date: 2005-05-09; US20060784793P Applic. Date: 2006-03-21

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; BESONOV ALEX [IL]

Title: Pressure-sensitive adhesive for the skin and tapes or sheets for the skin made by using the same

Applicant/Assignee: COSMED PHARMACEUTICAL CO., LTD

Application No.: 10/486115   Filing Date: 09/Feb/2004

Abstract:

The invention provides a pressure-sensitive adhesive for the skin excellent in pressure-sensitive adhesiveness to the human skin and repeelability therefrom, which does not cause the horny layer to be torn away in peeling and is lowly irritant to the skin

and tapes or sheets made by using the same.

The pressure-sensitive adhesive is characterized by comprising (a) 100 parts by weight of a copolymer which is prepared from an olefinic macromonomer and a vinyl monomer and whose molecular weight (in terms of polystyrene and as determined by gel permeation chromatography (GPC)) has a two-peak distribution (with the proviso that when the copolymer is to be post-cured, the distribution is one as determined before the post cure) and (b) 20 to 250 parts by weight of a softener which is compatible with the copolymer and liquid or pasty at room temperature and has a boiling point of 250 or above (with the proviso that when the content of the softener (b) exceeds 80 parts by weight, the copolymer must be post-cured).

Priority: JP20010278905 Applic. Date: 2001-08-10; WO2002JP08153 Applic. Date: 2002-08-08

Inventor: KOHARA MINORU [JP]

Title: Controlled release transdermal drug delivery

Applicant/Assignee: ROCKY MOUNTAIN BIOSYSTEMS, INC

Application No.: 10/422288   Filing Date: 24/Apr/2003

Abstract:

Provided herein is a device for controlling the release of a substance at a site of interest in a biological membrane comprising a means of monitoring a physiological state at the site of interest

and a means of releasing a variable amount of the substance to the site of interest where the amount varies in response to the status of the monitored physiological state. Also provided are methods of using the device.

Priority: US20020376112P Applic. Date: 2002-04-29

Inventor: MARCHITTO KEVIN S [US]; FLOCK STEPHEN T [US]

Title: Method, apparatus, and kit for onychomycosis treatment

Applicant/Assignee: POWER PAPER LTD

Application No.: 10/890297   Filing Date: 14/Jul/2004

Abstract:

Methods, apparatus, and kits for onychomycosis treatment are presented. In one embodiment, a kit for treatment includes an anti-fungal agent, in a composition, and an electrically powered patch. Exemplary embodiments of the patch include a first electrode, a power source having a first and second terminal, a second electrode coupled to the second terminal of the power source, and a base member supporting the first electrode, the second electrode, and the power source. Embodiments include those where the first and second electrode and power source are printed on the base member. Anti-fungal agents may be unionized while the composition includes an ionizing agent. Home use may be practiced, as embodiments include those in which the voltage or current of the power source cannot be adjusted by a user.

Exemplary methods include the selection of a nail or diseased area to which treatment is desired and administering the kit as described.

Priority: US20030486973P Applic. Date: 2003-07-14

Inventor: NITZAN ZVIKA [IL]; TAMARKIN DOV [IL]; MAVOR DANIELA [IL]; HAREL NURIT [IL]; EMANUEL NOAM [IL]

Title: Child's Fragrant Cleaning Implement

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 12/024435   Filing Date: 01/Feb/2008

Abstract:

A disposable child sized cleaning implement is provided. The disposable child sized cleaning implement is releasably carrying a personal care composition which comprises a fragrance composition.

Priority: US2004-948476 Applic. Date: 2004-09-23; US2003-737236 Applic. Date: 2003-12-16

Inventor: BENJAMIN JOYCE MARIE [US]; MASON MICHAEL WAYNE [US]; MASON JENNA [US]

Title: Disposable non-woven pad and method for entrapping pet hair and dander

Applicant/Assignee:

Application No.: 10/876310   Filing Date: 24/Jun/2004

Abstract:

A pad comprising at least one high loft non-woven layer for entrapping pet particles such as pet hair and pet dander from a pet or other items such as furniture or clothing, and a method for entrapping pet particles. The pad preferably includes a cling-enhancing substance. The pad can also include deodorizing agents, an impermeable layer, or a middle absorbent layer for absorbing moisture from or applying treatments to a pet.

Priority: US2003-745147 Applic. Date: 2003-12-23; US2002-269713 Applic. Date: 2002-10-11; US2001-033862 Applic. Date: 2001-12-20

Inventor: YANANTON PAT [US]

Title: Medical films and articles prepared from emulsion polymers

Applicant/Assignee: ROHM AND HAAS COMPANY

Application No.: 11/335721   Filing Date: 19/Jan/2006

Abstract:

Protective film forming compositions useful as medical films and other related wound care and treatment articles, including liquid bandages are prepared from emulsion polymers, including a polymer blend including at least one hard emulsion polymer component and at least one soft emulsion polymer component, having the required dynamic storage modulus and mean Tg of the hard and soft polymer blend components.

Priority: US20050648234P Applic. Date: 2005-01-28

Inventor: KARPOWICZ RICHARD [US]; NAKATANI ALAN I [US]; RICE KATHERINE SUE [US]

Title: Automated insomnia treatment system

Applicant/Assignee: CONSOLIDATED RESEARCH OF RICHMOND, INC CONSOLIDATE RESEARCH OF RICHMOND, INC

Application No.: 10/790885   Filing Date: 01/Mar/2004

Abstract:

Automated behavioral methods and systems for treating insomnia that use passive means for determining wake/sleep states.

Priority: US20030451055P Applic. Date: 2003-02-28

Inventor: KAPLAN RICHARD [US]; LOPARO KENNETH A [US]

Title: Methods and compositions for detection and diagnosis of infectious diseases

Applicant/Assignee: JAPAN BCG LABORATORY

Application No.: 11/020974   Filing Date: 22/Dec/2004

Abstract:

Methods and compositions for the detection and diagnosis of infectious diseases are provided. In particular, efficient and sensitive methods and compositions for the detection of active mycobacterial disease are provided for distinguishing between individuals having active disease, and individuals who have been immunologically exposed, such as those infected with a mycobacterium but are without active disease, or those who have been vaccinated with BCG. The methods comprise topical application of antigen compositions for transdermal delivery.

Priority: US2001-877802 Applic. Date: 2001-06-06; US1999-244701 Applic. Date: 1999-02-04; US19980073911P Applic. Date: 1998-02-06; US19980096140P Applic. Date: 1998-08-11

Inventor: NAKAMURA REIKO M [JP]

Title: SOLUBILIZING SYSTEMS FOR FLAVORS AND FRAGRANCES

Applicant/Assignee: FIRMENICH SA

Application No.: 11/689635   Filing Date: 22/Mar/2007

Abstract:

The present invention provides compositions and clear oil-in-water microemulsion containing up to 80% w/w of an oil, a surfactant system, a w/w oil/surfactant system ratio between 1 and 3, and a solubilizing-aid ingredient which is not a surfactant neither a VOC compound, the latter being present in an amount sufficient to ensure that the ratio oil/(surfactant+solubilizing-aid) is between 0.1 and 5. The present invention concerns also the articles and products associated with such compositions and microemulsions, and the methods to manufacture them.

Priority: EP20040105185 Applic. Date: 2004-10-20; WO2005IB03329 Applic. Date: 2005-10-19; US20040620557P Applic. Date: 2004-10-20

Inventor: VLAD FLORIN JOSEPH [US]; MOUNIER REMY [FR]; WONG KENNETH [CH]; DAUGERON AUDE [FR]; HERD THOMAS [US]

Title: PRODRUGS OF CC-1065 ANALOGS

Applicant/Assignee: IMMUNOGEN INC

Application No.: 12/144612   Filing Date: 23/Jun/2008

Abstract:

Prodrugs of analogs of the anti-tumor antibiotic CC-1065 having a cleavable protective group such as a piperazino carbamate, a 4-piperidino-piperidino carbamate or a phosphate, in which the protecting group confers enhanced water solubility and stability upon the prodrug, and in which the prodrug also has a moiety, such as a disulfide, that can conjugate to a cell binding reagent such as an antibody. The therapeutic use of such prodrug conjugates is also described

such prodrugs of cytotoxic agents have therapeutic use because they can deliver cytotoxic prodrugs to a specific cell population for enzymatic conversion to cytotoxic drugs in a targeted fashion.

Priority: US2007-649822 Applic. Date: 2007-01-05; US2005-217351 Applic. Date: 2005-09-02; US2003-692856 Applic. Date: 2003-10-27; US2002-116053 Applic. Date: 2002-04-05

Inventor: ZHAO ROBERT YONGXIN [US]; CHARI RAVI V J [US]

Title: Triple anti-irritant composition

Applicant/Assignee: MEDICIS PHARMACEUTICAL CORPORATION

Application No.: 10/884146   Filing Date: 02/Jul/2004

Abstract:

The present invention relates to a composition comprising two or more anti-irritants, each having at least about 7.2% oxygen content. In a separate embodiment, the composition may be defined to include a skin conditioning agent, a skin protectant agent, and an anti-irritant agent, each having an oxygen content of at least about 7.2%. The invention further comprises methods of treating and preventing skin conditions by applying the composition to the skin, and then optionally washing the skin.

Priority:

Inventor: BHATIA KULJIT S [US]; PATEL BHIKU G [US]; GANS EUGENE H [US]

Title: Cosmetic devices

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 10/268556   Filing Date: 10/Oct/2002

Abstract:

The present invention relates to pre-formed devices for delivering benefit agents to the skin, hair or nails. The devices are patches or masks for cosmetic or therapeutic use and comprise a unilamellar, solid gel sheet having at least one surface at least partially coated with a discrete coating composition comprising at least one benefit agent for the skin, hair or nails. The invention also encompasses methods of producing and using such devices. The coating composition allows more efficient delivery of benefit agents to the skin than previously known devices and/or affords greater formulation flexibility.

Priority: WO2000US09694 Applic. Date: 2000-04-12

Inventor: DECKNER GEORGE ENDEL [US]; JENKINS DELYTH MYFANWY [GB]; KYTE KENNETH EUGENE [US]; LEBLANC MICHAEL JUDE [US]; PHILLIPS JENNIFER ELIZABETH [US]

Title: Transdermal delivery peptides and method of use thereof

Applicant/Assignee: NOVOMED TECHNOLOGIES, INC. (SHANGHAI) UNIVERSITY OF SCIENCE & TECHNOLOGY OF CHINA

Application No.: 11/531879   Filing Date: 14/Sep/2006

Abstract:

Transdermal delivery peptides for the treatment of skin diseases and/or facilitation or enhancement of transdermal delivery of pharmaceutically active agents are provided. Compositions comprising the transdermal delivery peptides and methods of therapeutic use, including the improvement of transdermal delivery of drugs or other pharmaceutically active agents, are also disclosed. Nucleic acids, expression vectors, and methods of their use, which encode the transdermal delivery peptides are disclosed. Methods are also provided for in vivo phage display for identifying further peptides with enhanced transdermal delivery capability.

Priority: US20050717497P Applic. Date: 2005-09-15; US20050740613P Applic. Date: 2005-11-29

Inventor: WEN LONG-PING [CN]; CHEN YONGPING [CN]; SHEN YUANYUAN [CN]; GUO XIN [CN]; WANG WEIPING [CN]; ZHANG BRIAN [US]

Title: Protein matrix materials, devices and methods of making and using thereof

Applicant/Assignee: GEL-DEL TECHNOLOGIES, INC

Application No.: 09/796170   Filing Date: 28/Feb/2001

Abstract:

The present invention relates to protein matrix materials and devices and the methods of making and using protein matrix materials and devices. More specifically the present invention relates to protein matrix materials and devices that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, encapsulated or coated stent devices, vessels, tubular grafts, vascular grafts, wound healing devices including protein matrix suture material and meshes, skin/bone/tissue grafts, biocompatible electricity conducting matrices, clear protein matrices, protein matrix adhesion prevention barriers, cell scaffolding and other biocompatible protein matrix devices.

Furthermore, the present invention relates to protein matrix materials and devices made by forming a film comprising one or more biodegradable protein materials, one or more biocompatible solvents and optionally one or more pharmacologically active agents. The film is then partially dried, rolled or otherwise shaped, and then compressed to form the desired protein matrix device.

Priority: US1998-160421 Applic. Date: 1998-09-25; US20000185420P Applic. Date: 2000-02-28; US20000222762P Applic. Date: 2000-08-03

Inventor: MASTERS DAVID B [US]

Title: Topical compositions comprising benfotiamine and pyridoxamine

Applicant/Assignee: TRACIE MARTYN INTERNATIONAL, LLC

Application No.: 11/218226   Filing Date: 31/Aug/2005

Abstract:

The present invention provides a composition comprising an effective amount of benfotiamine and an effective amount of pyridoxamine in a suitable vehicle for topical application. The present compositions are useful in improving the appearance of aged skin characterized by wrinkles, loss of elasticity, and hyperpigmentation caused by chronoaging and/or photoaging of skin, by inhibiting particularly skin damage resulting from reactive carbonyl species (RCS), glycation of skin proteins, formation of advanced glycation endproducts (AGEs) and formation of advanced lipoxidation endproducts (ALEs).

Priority: US20040605750P Applic. Date: 2004-08-31

Inventor: MORARIU MARIUS [US]

Title: Cosmetic composition comprising an essential oil extracted from Helichrysum italicum

Applicant/Assignee: L'OCCITANE, A CORPORATION OF FRANCE, Z.I. SAINT -MAURICE, F-04100 MANOSQUE-EN-PROVENCE, FRANCE L'OCCITANE

Application No.: 10/785237   Filing Date: 24/Feb/2004

Abstract:

An antiwrinkle cosmetic composition comprising a substantially purified essential oil extracted from flower tops of Helichrysum italicum and a method of treating wrinkles in skin comprising applying on the skin an effective quantity of a cosmetic composition.

Priority: FR20010011224 Applic. Date: 2001-08-29; WO2002FR02954 Applic. Date: 2002-08-28

Inventor: MILLOU YVES [FR]; FONTES KATIA [FR]; TOUREL CECILE [FR]

Title: Liquid cleanser compositions

Applicant/Assignee: KIMBERLY-CLARK WORLDWIDE, INC

Application No.: 10/829518   Filing Date: 22/Apr/2004

Abstract:

Aqueous liquid cleanser compositions are disclosed. The cleanser compositions are structured liquids capable of suspending a skin benefit agent therein to improve transfer of the skin benefit agent to the skin upon use of the wash. In one embodiment, the skin benefit agent is a lipid material, which remains on the skin after washing to provide skin barrier enhancement.

Priority:

Inventor: KRZYSIK DUANE G [US]; UTSCHIG JULIE M [US]

Title: Medicament comprising a reducing alkyl-sugar monomer for the treatment of inflammatory disorders

Applicant/Assignee: CENTRE NATIONAL DE LA RECHESRCHE SCIENTIFIQUE (CNRS) PIERRE FABRE DERMO-COSMETIQUE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

Application No.: 10/577444   Filing Date: 29/Oct/2004

Abstract:

The invention relates to a medicament comprising at least one reducing alkyl-sugar monomer having a hydroxyl function which is substituted by an alkoxy radical at C2-C40, said medicament being preferably intended to regulate inflammatory mechanisms. The reducing sugar is preferably selected from the group containing rhamnose, fucose and glucose. The invention also relates to a cosmetic treatment method involving the topical application of a composition comprising at least one reducing alkyl-sugar monomer having a hydroxyl function which is substituted by an alkoxy radical at C2-C40.

Priority: FR20030012798 Applic. Date: 2003-10-31; WO2004FR02794 Applic. Date: 2004-10-29

Inventor: HOULMONT JEAN-PHILIPPE [FR]; RICO-LATTES ISABELLE [FR]; PEREZ EMILE [FR]; BORDAT PASCAL [FR]

Title: Alcoholic pump foam

Applicant/Assignee: STOCKHAUSEN GMBH

Application No.: 11/312559   Filing Date: 21/Dec/2005

Abstract:

An alcoholic foam composition, which can be dispensed as a foam via a pump-foam system contains a) at least 52 to !<=99 wt % of an alcohol or mixture of alcohols, b) a surfactant or a surfactant mixture, c) at least one polyalkylene glycol, d) optionally, at least one foam stabilizer, e) optionally, at least one member selected from the group consisting of cosmetic auxiliaries, adjuvants, active ingredients, and mixtures thereof, and f) optionally water. The surface tension of component b) lies in the range of +-15 dyn/cm of the surface tension of component a) or corresponds to the surface tension of component a), and the sum of components a) to f) is 100 wt % relative to the total quantity of the foam composition.

Priority: DE200410062775 Applic. Date: 2004-12-21

Inventor: VEEGER MARCEL [DE]; HIMMING MARKUS [DE]

Title: Transdermal administration of (r)-3,3-diphenylpropylamin-monoesters

Applicant/Assignee: SCHWARZ PHARMA AG

Application No.: 10/533683   Filing Date: 26/Apr/2005

Abstract:

The invention relates to a device for transdermally administering a compound of formula (I), wherein A represents hydrogen or deuterium, R represents a group selected among C1-4alkyl, C3-10cycloalkyl, or phenyl, each of which can be substituted by C1-3alkoxy, fluoride, chlorine, bromine, iodine, nitro, amino, hydroxy, oxo, mercapto, or deuterium, the C atom marked by * (asterisk) being provided in the R configuration. The invention is characterized in that the compound of general formula (I) is provided in a polymer matrix and is released at a dose of 0.5 to 20 mg per day through human skin. The invention further relates to the use of said compounds of formula (I) for producing transdermal medicaments.

Priority: DE20031015878 Applic. Date: 2003-04-08; WO2004EP03574 Applic. Date: 2004-04-03

Inventor: BREITENBACH ARMIN [DE]; MEESE CLAUS [DE]; WOLFF HANS-MICHAEL [DE]; DREWS ROLAND [DE]

Title: Cleansing composition containing hydrophilic silica and oxyalkenylated compounds

Applicant/Assignee: L' OREAL L'OREAL

Application No.: 09/903785   Filing Date: 13/Jul/2001

Abstract:

A cleansing composition comprising (1) at least one foaming surfactant, (2) at least 1% by weight of at least one hydrophilic silica, relative to the total weight of the composition, and (3) at least one oxyalkylenated compound in a physiologically acceptable aqueous medium comprising at least 35% by weight of water, relative to the total weight of the composition.

Priority: FR20000009225 Applic. Date: 2000-07-13

Inventor: SEBILLOTTE-ARNAUD LAURENCE [FR]; GUILLOU VERONIQUE [FR]

Title: Dermopharmaceutically and cosmetically active oligopeptides

Applicant/Assignee: DSM IP ASSETS B.V

Application No.: 10/493856   Filing Date: 18/Oct/2004

Abstract:

Oligopeptides and derivatives thereof, peptide analogs and derivatives thereof as well as pharmaceutically acceptable salts of these compounds, which correspond to general formula (I) wherein R1 represents H, -C(O)-R7, -SO2-R7, -C(O)-OR7 or -C(O)-N(R7)2 R2 represents, independent of one another, H or -(C1-C4)-alkyl, R3 and R6 represent, independent of one another, -(CH2)q-N(R1)R8 R4 and R5 represent, independent of one another, -CH2-OR2, -CH(CH3)OR8 or -CH2-CH2-OR8 R7 represents hydrogen, optionally substituted (C1-C19)-alkyl

optionally substituted (C1-C19)-alkenyl

phenyl-(C1-C4)-alkyl whose phenyl radical is optionally substituted with amino in the para position R8 represents H, -(C1-C4)-alkyl, -C(O)-R7, -C(O)-OR7, -C(O)-N(R7)2 or -SO2-R7 X represents oxygen (-O-) or -NH-

or XR7, with X=O, also represents the esters of [alpha]-tocopherol, tocotrienol or retinol or the carboxylic acid (with R7=H) m, n, p represent, independent of one another, zero or 1 and q in R3 and R6 represent, independent of one another, an integer from 1 to 4, with the provision that the following conditions do not simultaneously occur: R4=-CH(CH3)-OH and R5=-CH(CH3)-OH and R6=-(CH2)4-NH2

dermopharmaceutically and/or cosmetically active compositions containing at least one compound of formula (I).

Priority: CH20010001986 Applic. Date: 2001-10-30; WO2002CH00587 Applic. Date: 2002-10-30

Inventor: LUDIN CHRISTIAN [CH]; HEIDL MARC [DE]; ZIEGLER HUGO [CH]

Title: Antimicrobial and anticancer lipopeptides

Applicant/Assignee: YEDA RESEARCH & DEVELOPMENT CO. LTD

Application No.: 10/560727   Filing Date: 18/Jun/2004

Abstract:

Lipophilic conjugates comprise a peptide coupled to a fatty acid. The peptide comprises at least two positively charged amino acid residues

the peptide after conjugation to the fatty acid possessing antibacterial, antifungal, and/or anticancer activity higher than prior to conjugation. The lipophilic conjugates are suitable for treatment of infections caused by pathogenic organisms such as bacteria and fungi. The lipophilic conjugates are also suitable for sanitation, as disinfectants, or for food preservation.

Priority: US20030479465P Applic. Date: 2003-06-19; WO2004IL00544 Applic. Date: 2004-06-18

Inventor: SHAI YECHIEL [IL]; AVRAHAMI DORIT [IL]

Title: Topical anti-microbial compositions

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY ARCH CHEMICALS, INC

Application No.: 11/299195   Filing Date: 08/Dec/2005

Abstract:

Disclosed are topical compositions for the treatment of microbial infections on the skin or scalp which include a polyvalent metal salt of pyrithione and include a metal ion source. Also disclosed are methods for treating microbial infections of the skin or scalp using such compositions.

Priority: US2000-599624 Applic. Date: 2000-06-22

Inventor: GAVIN DAVID FRANCIS [US]; MARCHETTA ANTHONY RAYMOND [US]; NELSON JR JOHN DANIEL [US]; POLSON GEORGE [US]; SCHWARTZ JAMES ROBERT [US]; TURLEY PATRICIA AILEEN [US]

Title: [1,2,4]-Dithiazoli(di)ne derivatives, inducers of gluthathione-S-transferase and NADPH quinone oxido-reductase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular

Applicant/Assignee: SOLVAY PHARMACEUTICALS B.V

Application No.: 11/349910   Filing Date: 09/Feb/2006

Abstract:

The present invention relates to 5-imino-5H-[1,2,4]-dithiazol-3-yl-amine and [1,2,4]-dithiazolidine-3,5-diylidene-diamine derivatives as inducers of gluthathione-S-transferase (GST) and NADPH quinone oxidoreductase (NQO), to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said [1,2,4]-dithiazoli(di)ne derivatives. The invention also relates to the use of a compound disclosed herein for the treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular. The invention relates to compounds of the general formula (I): wherein wherein the symbols have the meanings given in the specification.

Priority: US20050651661P Applic. Date: 2005-02-11

Inventor: FEENSTRA ROELOF W [NL]; KEIZER HISKIAS G [NL]; PRAS-RAVES MARIA L [NL]; VAN VLIET BERNARD J [NL]; VAN SCHARRENBURG GUSTAAF J M [NL]

Title: Light emitting interface displays for a gaming machine

Applicant/Assignee: IGT

Application No.: 10/139801   Filing Date: 03/May/2002

Abstract:

A disclosed thin light-emitting interface displays may be mounted to a surface on the gaming machine. The light-emitting elements used in the interface displays may be provided from electro-luminescent elements, organic light emitting diode (OLED) elements and combinations thereof. The thin light-emitting interface displays may be used to input and output gaming information on the gaming machine. The gaming information that is input and output via the interface display may be used to provide: 1) a game of chance played on the gaming machine, 2) player tracking services, 3) game services available on the gaming machine and 4) attract features. In one embodiment, a game input interface display is provided with a plurality of input buttons where a number and a format of the input buttons are dynamically configurable for different types of games of chance played on the gaming machine.

Priority: US20010288603P Applic. Date: 2001-05-04

Inventor: WINANS RON [US]; OLLINS RICHARD [US]

Title: Pharmaceutical composition for topical application

Applicant/Assignee: FOAMIX LTD

Application No.: 11/294318   Filing Date: 05/Dec/2005

Abstract:

A pharmaceutical or cosmetic carrier or composition for topical application characterized by rheological properties which render the carrier or composition semi-solid at rest and a liquid upon application of shear forces thereto. The composition or carrier are prepared by mixing 1-25 percent of a solidifying agent and 75-99 percent of a hydrophobic solvent, by weight, wherein at least one of them has therapeutic or cosmetic benefits, in the presence or absence of a biologically active substance.

Priority: US2003-392071 Applic. Date: 2003-03-19; US2000-653267 Applic. Date: 2000-08-31; US20000216162P Applic. Date: 2000-07-03; WO2001IL00025 Applic. Date: 2001-01-10; IL20000133968 Applic. Date: 2000-01-10; IL20000133969 Applic. Date: 2000-01-10; IL20000137051 Applic. Date: 2000-06-27; IL20000137052 Applic. Date: 2000-06-27; IL20020150644 Applic. Date: 2002-07-17; US2000-526509 Applic. Date: 2000-03-16

Inventor: EINI MEIR [IL]; TAMARKIN DOV [IL]

Title: High alcohol content gel-like and foaming compositions comprising an anionic phosphate fluorosurfactant

Applicant/Assignee: DEB WORLDWIDE HEALTHCARE INC

Application No.: 11/507626   Filing Date: 22/Aug/2006

Abstract:

This invention relates to a "high lower alcohol content" (>40% v/v of a C1-4 alcohol) liquid composition able to be either dispensed as a stable foam with the use of non-propellant foam dispensing devices from non-pressurized containers or as an alcohol gel composition which does not use thickener and gelling agents that leave undesirable deposits or a sticky after-feel and that has a final viscosity less than 4,000 cps. The liquid compositions comprise an alcohol, C1-4 (>40% v/v), a fluorosurfactant of at least 0.001% by weight to prepare a foamable composition or from 0-2.0% to prepare a gel-like composition of a final viscosity less than 4,000 cps, 0-10% w/w of additional minor components added to obtain the desired performance (a foamable composition or a gel-like composition with a viscosity less than 4,000 cps), and the balance being purified water.

The compositions may include emulsifier-emollients and moisturizers, secondary surfactants, foam stabilizers, fragrances, antimicrobial agents, other type of medicinal ingredients, and the like ingredients or additives or combinations thereof commonly added to alcohol gels or foams, aerosol compositions or to toiletries, cosmetics, pharmaceuticals and the like.

Priority: US2004-952474 Applic. Date: 2004-09-29; US20030506172P Applic. Date: 2003-09-29; US20040591601P Applic. Date: 2004-07-28

Inventor: KOIVISTO BRUCE MICHAEL [CA]; FERNANDEZ DE CASTRO MARIA TERESA [CA]

Title: Jasmonate derivative compounds pharmaceutical compounds and methods of use thereof

Applicant/Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD

Application No.: 12/198559   Filing Date: 26/Aug/2008

Abstract:

The present invention provides novel jasmonate derivative compounds, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for treatment of cancers, especially mammalian cancers.

Priority: US2007-581546 Applic. Date: 2007-02-23; WO2004IL01098 Applic. Date: 2004-12-01; US20030526081P Applic. Date: 2003-12-02

Inventor: FLESCHER ELIEZER [IL]; KASHMAN YOEL [IL]; REISCHER DORIT [IL]; SHIMONY SHIRI [IL]

Title: Devices and bandages for the treatment or prevention of scars and/or keloids and methods and kits therefor

Applicant/Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Application No.: 11/888978   Filing Date: 03/Aug/2007

Abstract:

Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.

Priority: US20060835654P Applic. Date: 2006-08-03

Inventor: GURTNER GEOFFREY C [US]; DAUSKARDT REINHOLD H [US]; LONGAKER MICHAEL T [US]; YOCK PAUL [US]

Title: Gel composition for skin care and protection and a method for preparation thereof

Applicant/Assignee: DEAD SEA LABORAORIES, LTD

Application No.: 09/582522   Filing Date: 17/Dec/1998

Abstract:

The present invention relates to a gel composition useful for skin care and protection comprising up to 80% w/w Dead Sea water (or similarly constituted water), solubilizers, gelling agents or viscosity modifiers and deionized water to complete up to 100%. Preferably, the composition is a clear liquid gel. The gel optionally comprises hydrophobic and/or hydrophilic active agents. In the composition of the present invention the hydrophobic active agents may be vegetable oils, free fatty acids or vitamins, or any combination thereof and the hydrophilic active agent may be humectants, [alpha]-hydroxy acids, anti irritant agents, plant extracts, moisturizing agents or hydrolyzed plant proteins or any combination thereof. The gel may further comprise antioxidants and fragrances.

Priority: IL19970122776 Applic. Date: 1997-12-28; WO1998IL00615 Applic. Date: 1998-12-17

Inventor: MAOR ZEEV [IL]; KOGAN ASSIA [IL]; MAGDASSI SHLOMO [IL]; YEHUDA SHAUL [IL]

Title: Transporter enhanced corticosteroid activity

Applicant/Assignee:

Application No.: 11/802403   Filing Date: 22/May/2007

Abstract:

Methods and compositions for enhancing the activity and/or duration of action of loteprednol etabonate and other soft anti-inflammatory steroids of the haloalkyl 17[alpha]-alkoxycarbonyloxy-11[beta]-hydroxyandrost-4-en-3-one-17[beta]-carboxylate type and the corresponding [Delta]1,4-compounds are described. The enhancing agents have the formula: wherein Z1 is carbonyl, [beta]-hydroxymethylene or methylene

R2 is H, -OH or -OCOR3 wherein R3 is C1-C5 alkyl

Y is -OH, -SH or -OCOR4 wherein R4 is C1-C5 alkyl, cyclopentylethyl or diethylaminoethyl

and the dotted line in ring A indicates that the 1,2-linkage is saturated or unsaturated.

Priority: US20060808118P Applic. Date: 2006-05-25

Inventor: BODOR NICHOLAS S [US]

Title: Repeat sequence protein polymer active agent congjugates, methods and uses

Applicant/Assignee: GENENCOR INTERNATIONAL, INC

Application No.: 11/351712   Filing Date: 10/Feb/2006

Abstract:

Biomolecular conjugates are provided which comprise the conjugation product of a repeat sequence protein polymer and at least one active agent. Additional aspects provide methods for their manufacture and various industrial and consumer applications.

Priority: US2004-845936 Applic. Date: 2004-05-14; US20030470464P Applic. Date: 2003-05-14

Inventor: COLLIER KATHERINE D [US]; CUEVAS WILLIAM A [US]; KUMAR MANOJ [US]

Title: Polyurethane foams comprising oligomeric polyols

Applicant/Assignee: CARGILL, INCORPORATED

Application No.: 11/411357   Filing Date: 25/Apr/2006

Abstract:

The invention relates to polyurethane foams comprising oligomeric polyols. In embodiments of the invention, the polyurethane foams comprise the reaction product of: (a) a polyisocyanate

and (b) an active-hydrogen containing composition comprising an oligomeric polyol having a hydroxyl number of about 45 to about 65 mg KOH/g, a number average hydroxyl functionality (Fn) of less than about 2.7, and about 40% weight or greater oligomers. The polyurethane foams of the invention may be slabstock foams or molded foams. Also disclosed are low odor polyols and polyurethane compositions.

Priority: US20050674879P Applic. Date: 2005-04-25; US20050677272P Applic. Date: 2005-05-02; US20050741123P Applic. Date: 2005-12-01; US20060786594P Applic. Date: 2006-03-27

Inventor: ABRAHAM TIMOTHY W [US]; CARTER JACK A [US]; DOUNIS DIMITRI [US]; MALSAM JEFF [US]

Title: Diphenyl Urea Derivatives

Applicant/Assignee: ARIPIDA AG ARPIDA AG

Application No.: 12/096831   Filing Date: 08/Dec/2006

Abstract:

The invention relates to novel specifically trifluoromethyl and halogen substituted 1,3-diphenyl ureas and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects like the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as anti-infectives.

Priority: WO2005EP13345 Applic. Date: 2005-12-13; WO2006EP11795 Applic. Date: 2006-12-08

Inventor: LOEWE RALF [CH]; LOCIURO SERGIO [CH]; HAWSER STEPHEN [FR]; SCHMITT LAURENT [FR]

Title: SILOXANE POLYMERS AND USES THEREOF

Applicant/Assignee: HONEYWELL INTERNATIONAL INC

Application No.: 11/830479   Filing Date: 30/Jul/2007

Abstract:

A method for preparing a siloxane polymer comprising the steps of (a) providing an aldehyde-based redox initiator

and (b) reacting said redox initiator with a siloxane having a plurality of end-capped hydride moieties to form a siloxane polymer having a plurality of terminal aldehyde moieties.

Priority: US20060835013P Applic. Date: 2006-08-02

Inventor: ASIRVATHAM EDWARD T [US]

Title: Penetrating pharmaceutical foam

Applicant/Assignee: FOAMIX LTD FOAMIX, LTD

Application No.: 10/922358   Filing Date: 20/Aug/2004

Abstract:

The invention relates to an alcohol-free cosmetic or pharmaceutical foam composition comprising water, a hydrophobic solvent, a surface-active agent, a gelling agent, an active component selected from the group of urea, hydroxy acid and a therapeutic enhancer and a propellant. The foam further comprises active agents and excipients with therapeutic properties having enhanced skin penetration.

Priority: IL20020152486 Applic. Date: 2002-10-25; WO2003IB05527 Applic. Date: 2003-10-24; US2004-911367 Applic. Date: 2004-08-04; US20030497648P Applic. Date: 2003-08-25; US20020429546P Applic. Date: 2002-11-29; US20030492385P Applic. Date: 2003-08-04

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; EINI MEIR [IL]

Title: Cosmetic composition with skin tightening effect

Applicant/Assignee: LVMH RECHERCHE

Application No.: 10/487693   Filing Date: 26/Feb/2004

Abstract:

The present invention relates to a mixture, having a skin-tightening effect, which is made up of: 10 to 80% by weight of a polysaccharide, preferably of an alginate, having a molecular weight of less than 600,000 Daltons, preferably less than 400,000 Daltons and more preferably less than 200,000 Daltons, 15 to 75% by weight of a polyhydroxylated agent selected from sugars and their derivatives, particularly sugar esters and sugar ethers, preferably sorbitol, 3 to 15% by weight of poly(vinyl alcohol) or polyvinylpyrrolidone, and 0 to 25% by weight of cellulose or of a derivative of cellulose, such as carboxymethylcellulose or hydroxymethylcellulose. The present invention also relates to cosmetic compositions which contain this mixture.

These cosmetic compositions enable a mechanical smoothing of the surface of the skin to be obtained progressively with great comfort of use and enables a good fixing of make-up products.

Priority: FR20010011123 Applic. Date: 2001-08-27; WO2002FR02941 Applic. Date: 2002-08-27

Inventor: DELAGE-GROUILLER HERVE [FR]; NOE BRIGITTE [FR]; MAHE CHRISTIAN [FR]

Title: Cosmetics

Applicant/Assignee: TECHNOBLE CO., LTD

Application No.: 10/466322   Filing Date: 29/Jul/2003

Abstract:

Cosmetics containing an active component comprising lactic acid bacteria fermented rice obtained by fermenting rice with lactic acid bacteria

a skin brightening and caring agent comprising lactic acid bacteria fermented rice obtained by fermenting rice with lactic acid bacteria

and an emulsifier comprising as the main component lactic acid bacteria fermented rice obtained by fermenting rice with lactic acid bacteria substantially in the absence of sodium chloride. Thus, cosmetics can be obtained, which are excellent in emulsion stability and biological safety, have a good feeling when using and after using and further have a total beautifying effect of cosmetic treatment including an improving effect on hair texture, and brightening and caring effects on the skin.

Priority: JP20010024766 Applic. Date: 2001-01-31; JP20010052438 Applic. Date: 2001-02-27; JP20010082855 Applic. Date: 2001-03-22; JP20010150174 Applic. Date: 2001-05-18; WO2001JP06651 Applic. Date: 2001-08-02

Inventor: SAWAKI SHIGERU [JP]; SAWAKI SHIGETOYO [JP]; MATSUKAWA KIYOJI [JP]; OSAWA YUTAKA [JP]; HIROTA AYAKO [JP]; OGURA TAKAKO [JP]

Title: Cosmetic compositions comprising a fine and porous powder

Applicant/Assignee: ARKEMA FRANCE

Application No.: 11/268967   Filing Date: 08/Nov/2005

Abstract:

The invention is a water/oil emulsion including a porous powder, the particles of the powder having the following characteristics: an apparent specific surface of 1 to 299 m2/g, measured by nitrogen absorption according to the ISO 9277 BET method

a linseed oil absorption of between 45 g/100 g of powder and 160 g/100 g of powder, measured according to ISO 787-5. The mean diameter of the particles of the powder is between 2 [mu]m and 100 [mu]m, preferably from 2 to 50 [mu]m, more advantageously still from 2 to 20 [mu]m. The powder is chosen from a powder formed of polyamides, of polyesteramides, of polyurethanes, of poly(methyl methacrylate)s, of acrylic polymers, of polyesters, of silicones, of polyethylenes and of silicas.

The invention further relates to the use of the emulsion for obtaining a make-up and/or care product for the skin which is nonshiny, nonoily, nonsticky and/or nontacky, as well as the use of the fine powder for improving the feel and/or the appearance of a cosmetic emulsion.

Priority: FR20040012690 Applic. Date: 2004-11-30

Inventor: LOYEN KARINE [FR]; KOHLER SOPHIE [FR]

Title: Polytetrafluoroethylene binding peptides and methods of use

Applicant/Assignee: E. I. DU PONT DE NEMOURS AND COMPANY

Application No.: 11/607734   Filing Date: 01/Dec/2006

Abstract:

Combinatorially generated peptides are provided that have binding affinity for Polytetrafluoroethylene (PTFE). The peptides may be used to deliver benefit agents to various PTFE surfaces.

Priority: US20050750726P Applic. Date: 2005-12-15

Inventor: CUNNINGHAM SCOTT D [US]; LOWE DAVID J [US]; O'BRIEN JOHN P [US]; WANG HONG [US]; WILKINS ANTOINETTE E [US]

Title: Beta sheet tapes ribbons in tissue engineering

Applicant/Assignee: UNIVERSITY OF LEEDS

Application No.: 10/521628   Filing Date: 08/Sep/2005

Abstract:

There is described a material comprising ribbons, fibrils or fibres characterised in that each of the ribbons, fibrils or fibres have an antiparallel arrangement of peptides in a beta-sheet-tape-like substructure.

Priority: GB20020016286 Applic. Date: 2002-07-15; WO2003GB03016 Applic. Date: 2003-07-15

Inventor: BODEN NEVILLE [GB]; AGELLI AMALIA [GB]; INGHAM EILEEN [GB]; KIRKHAM JENNIFER [GB]

Title: Foamable vehicle and pharmaceutical compositions thereof

Applicant/Assignee: FOAMIX LTD FOAMIX, LTD

Application No.: 11/430599   Filing Date: 09/May/2006

Abstract:

A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG

0% to about 48% of a secondary polar solvent

about 0.2% to about 5% by weight of a surface-active agent

about 0.01% to about 5% by weight of at least one polymeric agent

and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.

Priority: US2004-835505 Applic. Date: 2004-04-28; US20030530015P Applic. Date: 2003-12-16; US20030492385P Applic. Date: 2003-08-04; US20050679020P Applic. Date: 2005-05-09; US20060784793P Applic. Date: 2006-03-21

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; EINI MEIR [IL]; BESONOV ALEX [IL]

Title: Cationic Cassia Derivatives and Applications Therefor

Applicant/Assignee: LUBRIZOL ADVANCED MARTERIALS, INC

Application No.: 12/254437   Filing Date: 20/Oct/2008

Abstract:

This invention relates to cationically derivatized polycalactomannans obtained from cassia tora and cassia obtusifolia and to their use in personal care, household care, and institutional care compositions.

Priority: US2007-843920 Applic. Date: 2007-08-23; US2004-874296 Applic. Date: 2004-06-18; US20030479793P Applic. Date: 2003-06-19

Inventor: LEPILLEUR CAROLE A [US]

Title: Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages

Applicant/Assignee: L'OREAL

Application No.: 11/202192   Filing Date: 12/Aug/2005

Abstract:

Inhibitors of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), for example tetrazole, styrylpyrazole, phenylfuran, phenylthiophene, phenylpyrrazole, pyrazolecarboxamide, 2-thioacetamide and azo compounds, are useful for promoting or stimulating pigmentation of the skin and/or skin appendages and/or for preventing and/or for limiting depigmentation and/or whitening of the skin and/or skin appendages, notably for preventing and/or limiting canities.

Priority: FR20030050023 Applic. Date: 2003-02-12; WO2004FR00325 Applic. Date: 2004-02-12; US20030456563P Applic. Date: 2003-03-24

Inventor: MICHELET JEAN-FRANCOIS [FR]; COMMO STEPHANE [FR]

Title: Compositions having improved soft focus effect properties

Applicant/Assignee: L'OREAL

Application No.: 11/342913   Filing Date: 31/Jan/2006

Abstract:

The invention relates to a composition, especially a cosmetic composition, containing at least one silicone elastomer and at least one encapsulated pigment, wherein the refractive index of the pigment is greater than the refractive index of the encapsulating material.

Priority:

Inventor: PATEL DHAVAL [US]

Title: Implantable preparations

Applicant/Assignee: KHORIONYX

Application No.: 11/499723   Filing Date: 07/Aug/2006

Abstract:

An implantable preparation comprises a material which can be obtained from globin that has been modified, especially chemically, to be, at least partially, soluble at physiological pH. The material is biocompatible, and biodegradable in the organism. The material may be soluble at physiological pH, or insoluble at that pH. The preparation may be in the form of a solution, suspension, paste, gel, film, sponge, powder or granules, or a solid implant. The preparation can be used for the healing, protection or filling of external skin wounds, the filling of wrinkles and skin flaws, the filling of tissue, as a device for fixing prostheses or biomaterials, or as a device for preventing adhesion.

Priority: FR20050008392 Applic. Date: 2005-08-05; US20060774607P Applic. Date: 2006-02-21

Inventor: TAYOT JEAN LOUIS [FR]

Title: Solid dispersions comprising aphrons

Applicant/Assignee: DISPERSE LIMITED

Application No.: 10/586328   Filing Date: 18/Jan/2005

Abstract:

A solid composition comprising oil core aphrons dispersed in a solid surfactant.

Priority: GB20040001101 Applic. Date: 2004-01-19; WO2005GB00162 Applic. Date: 2005-01-18

Inventor: MERCURIO ANTHONY FRED [US]; WHEELER DEREK ALFRED [GB]

Title: Therapeutic article including a personal care composition and methods of making the therapeutic article

Applicant/Assignee: KIMBERLY-CLARK WORLDWIDE, INC

Application No.: 11/300601   Filing Date: 14/Dec/2005

Abstract:

A therapeutic article includes a skin contact layer having a plurality of fibers forming a plurality of point-bearing surfaces configured for wear against a user's skin

a personal care composition disposed proximate the fibers

an external layer attached to the skin contact layer

and an intermediate layer interposed between the skin contact layer and the external layer, the intermediate layer being configured to activate the personal care composition, the external layer being configured to direct the activated personal care composition through the skin contact layer to treat the user.

Priority:

Inventor: GREENE SHARON L [US]; YANG KAIYUAN [US]; YANG SHU-PING [US]; WEI NING [US]; KYUNG JAI [US]; FISH JEFFREY E [US]

Title: Self forming, thermodynamically stable liposomes and their applications

Applicant/Assignee: BIOZONE LABORATORIES, INC

Application No.: 11/588068   Filing Date: 24/Oct/2006

Abstract:

Certain diacylglycerol-polyethyleneglycol (DAG-PEG) lipids are especially useful for forming thermodynamically stable liposomes. Such liposomes are useful for a variety of purposes, including the delivery of therapeutic agents.

Priority: US2005-178001 Applic. Date: 2005-07-08; US2002-262284 Applic. Date: 2002-09-30; US2000-745292 Applic. Date: 2000-12-20

Inventor: KELLER BRIAN CHARLES [US]; LASIC DANILO [US]

Title: PROTECTING AND REGENERATING COMPOSITION

Applicant/Assignee: LVMH RECHERCHE

Application No.: 11/668912   Filing Date: 30/Jan/2007

Abstract:

The invention relates to a protecting and regenerating composition. This composition comprises an association of a first cosmetically active ingredient comprising a dried vine shoot extract, and a second cosmetically active ingredient comprising a component of the ectoine type. This composition makes it possible to affect anti-ageing cosmetic care and skin revitalization.

Priority: FR20060050400 Applic. Date: 2006-02-03

Inventor: ANDRE PATRICE [FR]; RENIMEL ISABELLE [FR]

Title: Preparation method of a hair dermal papilla cell preparation, composition and method for regenerating hair follicles, and animal having regenerated hair follicles

Applicant/Assignee: SHISEIDO COMPANY, LTD

Application No.: 10/574697   Filing Date: 05/Apr/2006

Abstract:

The present invention provides a method for preparing a hair dermal papilla cell preparation comprising preparing a cell suspension by removing epidermal tissue from skin tissue and subjecting the resulting dermal tissue fraction to collagenase treatment, and cyropreserving the cell suspension to kill the follicular epidermal cells. The present invention also provides a composition for regenerating hair follicles comprising hair dermal papilla cell and epidermal cells, wherein the ratio of the number of hair dermal papilla cell to the number of epidermal cells is from 1:10 to 10:1.

Priority: JP20030346937 Applic. Date: 2003-10-06; JP20030346939 Applic. Date: 2003-10-06; JP20040048322 Applic. Date: 2004-02-24; WO2004JP14779 Applic. Date: 2004-09-30

Inventor: KISHIMOTO JIRO [JP]; EHAMA RITSUKO [JP]; IDETA RITSURO [JP]; ARAI TAKAYUKI [JP]; YANO KIICHIRO [JP]; SOMA TSUTOMU [JP]

Title: Quinazoline derivatives and medicaments

Applicant/Assignee: NIPPON SHINYAKU CO., LTD

Application No.: 10/512954   Filing Date: 26/Oct/2004

Abstract:

An object of the present invention is to provide an antipruritic agent having a novel action mechanism. The present invention provides an antipruritic agent comprising a compound represented by the following general formula (1): wherein R1 represents a hydrogen atom or alkyl

the ring Q represents a cyclohexylene group or a phenylene group

A1 and A2 represent a single bond or an alkylene group

E represents -NHCO-

A3 represents a single bond or a divalent saturated or unsaturated aliphatic hydrocarbon group

R3 represents a non-cyclic aliphatic hydrocarbon group

and R4 and R5 are the same or different and each represents a hydrogen atom or alkyl, or a pharmaceutically acceptable salt thereof as an active ingredient.

Priority: JP20020125452 Applic. Date: 2002-04-26; JP20020272314 Applic. Date: 2002-09-18; JP20020373400 Applic. Date: 2002-12-25; WO2003JP05432 Applic. Date: 2003-04-28

Inventor: OKANO MASAHIKO [JP]; OYAMA TATSUYA [JP]

Title: FOAMABLE COMPOSITIONS CONTAINING ALCOHOL

Applicant/Assignee: THE CLOROX COMPANY

Application No.: 11/466657   Filing Date: 23/Aug/2006

Abstract:

This invention relates to compositions containing lower (C1-C4) alcohol and a polymeric fluorosurfactant formulated for being dispensed as a foam product. More particularly, the invention relates to improved compositions formulated with polymeric fluorosurfactants with pendant perfluoroalkyl side chains of a fully fluorinated chain length of C1-C7. The compositions also relate to use for personal care, such as skin sanitizing and cleansing.

Priority:

Inventor: LESTAGE DAVID [US]; SCHEUING DAVID R [US]; CUMBERLAND SCOTT L [US]; TEMPLIN GRANT [US]

Title: Reduction of hair growth

Applicant/Assignee: THE PROCTER & GAMBLE COMPANY

Application No.: 11/709616   Filing Date: 22/Feb/2007

Abstract:

A method of reducing hair growth includes topical application of a TRPM8 and/or a TRPA1 agonist, alone or in conjunction with heat.

Priority: US20060777888P Applic. Date: 2006-02-28

Inventor: BOTCHKAREVA NATALIA [US]; SHANDER DOUGLAS [US]

Title: Stabilized compositions for topical administration and methods of making same

Applicant/Assignee: DPM THERAPEUTICS CORP

Application No.: 11/259778   Filing Date: 27/Oct/2005

Abstract:

A stabilizing composition that also enhances permeation is provided for the topical or transdermal administration of an active ingredient. The composition preferably comprises collagen, elastin, sphingoside and cerebroside. Also provided are pharmaceutical or cosmetic formulations comprising an effective amount of an active agent and the stabilizing composition as well as methods of administering active agents topically or transdermally.

Priority: US2005-057481 Applic. Date: 2005-02-14

Inventor: MODI PANKAJ [CA]

Title: Liquid compositions containing solubilized benzoyl peroxide

Applicant/Assignee:

Application No.: 11/820949   Filing Date: 21/Jun/2007

Abstract:

Liquid medicaments incorporate about 1.0-3.0% active benzoyl peroxide (BP) by weight in substantially fully solubilized form, while being substantially free of acetone and other harsh, dermatologically undesirable solvents. The novel compositions are produced by (a) creating an emulsion or slurry of BP in an emollient, topically acceptable ester, and (b) dissolving the emulsion or slurry in absolute alcohol. The medicaments may be used in the treatment of BP-responsive skin conditions in mammals, e.g., acne vulgaris or rosacea. The novel medicaments may be dispensed directly to the affected skin area through the use of an applicator device comprising a fluid reservoir associated with a foam applicator tip, or via a spray dispenser, atomizer or pump spray.

Priority:

Inventor: BLACKMAN STEVEN T [US]

Title: Transdermal Pharmaceutical Composition

Applicant/Assignee: RICHTER GEDEON VEGYESZETI GYAR RT

Application No.: 10/575145   Filing Date: 06/Oct/2004

Abstract:

The invention relates to a liquid crystal gel containing polyoxyethylene-glyceryl-trioleate, propylene-glycol, isopropyl myristate and a hyaluronic acid salt or complex for use in the manufacture of transdermal pharmaceutical compositions and healing cosmetics. The invention also relates to transdermal pharmaceutical composition consists of an estrogen and a progestin component as well as a liquid crystal gel containing polyoxyethylene-glyceryl-trioleate, propylene-glycol, isopropyl myristate and a hyaluronic acid salt or complex. The invention can be applied for transdermal hormone replacement therapy and for other transdermal depending on the active principles included.

Priority: HU20030003313 Applic. Date: 2003-10-09; WO2004HU00092 Applic. Date: 2004-10-06

Inventor: EROS ISTVAN [HU]; PANNONHALMINE CSOKA ILDIKO [HU]; SOOSNE CSANYI ERZSEBET [HU]; BODIS ATTILA [HU]; LAPIS ERZSEBET [HU]; FRANCSICSNE CZINEGE ERZSEBET [HU]; KISSNE CSIKOS EMOKE [HU]; ILLES JANOS [HU]

Title: Cosmetic Treatment for Body-Modelling with Sun Protection and Modelling Kit

Applicant/Assignee: COTY PRESTIGE LANCASTER GROUP GMBH

Application No.: 11/912638   Filing Date: 04/May/2006

Abstract:

The invention relates to a method for body shaping by means of a sun-protection agent and a corresponding cosmetic product. The inventive method consists in pre-treating by means of a preliminary product containing a caffeine, algae extract, pineapple extract, radical scavenger, copper gluconate, silylpropionic acid and a melanin-stimulating amino acid-containing agent, in subsequently treating by a main product containing, apart from an UVA- and UVB-Filter, at an ratio ranging from 30:70 to 70:30, a green coffee bean oil whose radical scavenger content is 30-60% less than this of the preliminary agent and in post-treating by means of an after-product which comprises the preliminary product constituents and whose silylpropionic acid content is of 2 to 10 times the content of the preliminary product.

Priority: DE200510021805 Applic. Date: 2005-05-04; WO2006EP62039 Applic. Date: 2006-05-04

Inventor: GOLZ-BERNER KARIN [MC]; ZASTROW LEONHARD [MC]

Title: Method and composition for the treatment of scars

Applicant/Assignee:

Application No.: 10/829315   Filing Date: 21/Apr/2004

Abstract:

A method and composition for treating healed wounds including hypertrophic scars so as to prevent scarring or reduce the size and improve the appearance of scars comprises applying to the healed wound or scar a composition comprising a fluid, film-forming carrier which may contain one or more active topical ingredients, the carrier hardening to a solid, tangible, membrane juxtaposed to the skin. Novel compositions using the film-forming carrier are also useful to treat a variety of adverse skin disorders, and internal physiological conditions.

Priority: US2001-022216 Applic. Date: 2001-12-20; US1999-441138 Applic. Date: 1999-11-17

Inventor: STUDIN JOEL R [US]

Title: Radiofrequency ablation with independently controllable ground pad conductors

Applicant/Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION

Application No.: 11/214398   Filing Date: 29/Aug/2005

Abstract:

A radiofrequency ablation system provides multiple ground pads and active control of current flow through the ground pads to provide improved power sharing at the tissue near the ground pads reducing risk of patient skin burns for higher power ablation generators.

Priority: US20040569896P Applic. Date: 2004-05-11; WO2005US16172 Applic. Date: 2005-05-09

Inventor: LEE JR FRED T [US]; WINTER III THOMAS CHARLES [US]; HAEMMERICH DIETER GEORG [AT]; SAMPSON LISA ANN [US]; GOLDBERG S NAHUM [US]

Title: COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING PEPTIDES, USES AND TREATMENT PROCESSES

Applicant/Assignee: SOCIETE D'EXTRACTION DES PRINCIPES ACTIFS S.A

Application No.: 12/134795   Filing Date: 06/Jun/2008

Abstract:

The present invention has as an aim a cosmetic and/or dermatological and/or pharmaceutical composition comprising, as an active ingredient, at least a peptide of sequence X1-Y-Phe-Thr-X2-Ala-Thr-Z-Ile-X3-Leu-X4-Phe-Leu-X5 (SEQ ID NO: 1)

wherein: X1, X2, X3, X4, X5=Arg, Lys, His

Y=Asp, Glu

Z=Asn, Gln, or one of its fragment containing from 4 to 7 amino acids, and the motif Phe-Leu. The invention also relates to a method for preventing or treating skin against the manifestations of cutaneous aging.

Priority: FR20020003306 Applic. Date: 2002-03-18; FR20080000611 Applic. Date: 2008-02-06; US2004-508245 Applic. Date: 2004-09-20; WO2003FR00817 Applic. Date: 2003-03-14

Inventor: DAL FARRA CLAUDE [FR]; DOMLOGE NOUHA [FR]; BOTTO JEAN-MARIE [FR]

Title: Organo-gel formulations for therapeutic applications

Applicant/Assignee: MEDIQUEST THERAPEUTICS, INC

Application No.: 10/960516   Filing Date: 08/Oct/2004

Abstract:

A composition suitable for the local delivery of cosmetic and/or pharmaceutical agents into the skin containing at least two biocompatible organic solvents, a polar lipid, a surfactant, water, urea and a thickener wherein the organic solvents include an ester and a dihydric and/or polyhydric alcohol is provided. Also disclosed are compositions that further contain a cosmetic and/or pharmaceutical agent, along with the preparation and use thereof.

Priority:

Inventor: DECHOW FREDERICK J [US]

Title: Compositions and methods for treating intervertebral discs with collagen-based materials

Applicant/Assignee: WARSAW ORTHOPEDIC, INC

Application No.: 11/030705   Filing Date: 06/Jan/2005

Abstract:

A method of augmenting an intervertebral disc nucleus by injecting or otherwise adding to a disc nucleus a plurality of particles of natural, collagen-rich tissue. The mean particle size of the pieces of natural, collagen-rich tissue may be between 0.25 mm and 1.0 mm. The particles may be dehydrated before implantation, and rehydrated after implantation, or they may be implanted in a "wet" state-such as a slurry or gel. Radiocontrast materials may be included to enhance imaging of the injected material. Other additives may include analgesics, antibiotics, proteoglycans, growth factors, stem cells, and/or other cells effective to promote healing and/or proper disc function.

Priority: US2002-245955 Applic. Date: 2002-09-18; US2003-704167 Applic. Date: 2003-11-07; US20020426613P Applic. Date: 2002-11-15

Inventor: TRIEU HAI H [US]; SHERMAN MICHAEL C [US]

Title: Stable composition with high electrolyte content containing an amphiphilic polymer

Applicant/Assignee: L'OREAL

Application No.: 10/181983   Filing Date: 24/Jul/2002

Abstract:

The present invention relates to a composition for topical application, comprising at least one electrolyte and at least one amphiphilic polymer including at least one ethylenically unsaturated monomer containing a sulphonic group, in free form or partially or totally neutralized form and comprising at least one hydrophobic portion. The invention also relates to the uses of the said composition, especially in cosmetics, to treat and care for human skin, the scalp, mucous membranes, the nails and keratin fibres.

Priority: FR20010000337 Applic. Date: 2001-01-11; WO2002FR00045 Applic. Date: 2002-01-08

Inventor: LORANT RALUCA [FR]; LENNON PAULA [FR]

Title: COMPOSITE STRUCTURES WITH INTEGRAL INTELLIGENT SKIN

Applicant/Assignee: GENERAL ATOMICS

Application No.: 12/419833   Filing Date: 07/Apr/2009

Abstract:

Composite structures having an integral intelligent skin are made of one or more plies of a structural base material and an intelligent or smart film by molding one or more plies and the film into an integral unitary body with the intelligent film outermost. The intelligent or smart film contains or bears a functionally active or interactive component such as antennae, electronic sensors, electric and/or electronic circuitry, and/or spectrally tailored coatings. A method of making the composite structure in a very economical manner is disclosed.

Priority: US2006-448284 Applic. Date: 2006-06-07

Inventor: MCGOVERN THOMAS R [US]; HUBBARD RONALD N [US]

Title: 3-Deoxyglucosone and skin

Applicant/Assignee: DYNAMIS THERAPEUTICS, INC

Application No.: 11/818997   Filing Date: 15/Jun/2007

Abstract:

The invention relates to a method of removing 3-deoxyglucosone and other alpha-dicarbonyl sugars from skin. The invention further relates to methods of inhibiting production and function of 3-deoxyglucosone and other alpha-dicarbonyl sugars in skin. The invention also relates to methods of treating 3-deoxyglucosone and other alpha-dicarbonyl sugars associated diseases and disorders of skin.

Priority: US2002-198706 Applic. Date: 2002-07-18; US20020392530P Applic. Date: 2002-06-27; US20020373103P Applic. Date: 2002-04-17

Inventor: TOBIA ANNETTE [US]; KAPPLER FRANCIS [US]

Title: Emollient skin conditioning cream and method

Applicant/Assignee: CRABTREE & EVELYN, LTD

Application No.: 09/964143   Filing Date: 25/Sep/2001

Abstract:

A cosmetic exfoliating composition for use in cleansing and conditioning the skin of the hand, face, heels/knees/elbows and/or body of a human being which is stable and which does not leave a greasy or tacky after-feel when said composition is applied to and rinsed from skin with water and the skin is dried.

Priority:

Inventor: MCLAUGHLIN JAMES HUGH [US]

Title: CLAY-BINDING PEPTIDES AND METHODS OF USE

Applicant/Assignee: E.I. DU PONT DE NEMOURS AND COMPANY

Application No.: 11/696380   Filing Date: 04/Apr/2007

Abstract:

Combinatorially generated peptides are provided that have binding affinity for clay. The peptides may be used to deliver benefit agents to various clay surfaces.

Priority: US20060790149P Applic. Date: 2006-04-06

Inventor: ITTEL STEVEN DALE [US]; CUNNINGHAM SCOTT D [US]; ROUVIERE PIERRE E [US]; FAHNESTOCK STEPHEN R [US]; O'BRIEN JOHN P [US]; SCHNEIDER EBERHARD [DE]; SCHURMANN GREGOR [DE]; WAGNER PETER [DE]

Title: Use of thermoplastic elastomers in a composition and compositions thereof

Applicant/Assignee: AVON PRODUCTS, INC

Application No.: 11/314634   Filing Date: 21/Dec/2005

Abstract:

Compositions and methods for the formation of physically cross-linked thermoplastic elastomeric films are disclosed. The disclosed films are long-lasting, flexible, transfer resistant, and water-proof. The film-forming compositions comprise a thermoplastic elastomer, a tackifier resin, and a volatile solvent useful for formulating cosmetics, personal care products, and pharmaceutical compositions.

Priority:

Inventor: BRAHMS JOHN C [US]; MAITRA PRITHWIRAJ [US]; ZHENG TAO [US]; BINDER DAVID A [US]

Title: Topical pharmaceutical formulations and methods of treatment

Applicant/Assignee: PHARMAKODEX LIMITED

Application No.: 10/312475   Filing Date: 23/Dec/2002

Abstract:

In certain embodiments, the present invention is directed to a pharmaceutical formulation for topical administration on a mammal, comprising a unit dose of a therapeutically effective amount of a therapeutic agent and a pharmaceutically acceptable carrier medium therefor, said formulation being solid at ambient temperature and having a softening point of not higher than 35 DEG C., such that when the formulation is placed in continuous contact with the skin of a mammalian patient, it is softened to a consistency to effect substantial application of the unit dose of said therapeutic agent onto a desired skin area of the mammalian patient within a time period of less than 10 minutes.

Priority: GB20000015617 Applic. Date: 2000-06-26; WO2001GB02823 Applic. Date: 2001-06-26

Inventor: STANIFORTH JOHN NICHOLAS [GB]; TOBYN MICHAEL JOHN [GB]

Title: PEPTIDES FOR BINDING CALCIUM CARBONATES AND METHODS OF USE

Applicant/Assignee: E. I. DU PONT DE NEMOURS AND COMPANY

Application No.: 11/828539   Filing Date: 26/Jul/2007

Abstract:

Combinatorially generated peptides are provided that have binding affinity for calcium carbonates. The peptides may be used to deliver benefit agents to various calcium carbonate surfaces.

Priority:

Inventor: CUNNINGHAM SCOTT D [US]; ITTEL STEVEN DALE [US]; O'BRIEN JOHN P [US]; ROUVIERE PIERRE E [US]

Title: Composition and method for the efficacious and safe administration of halopyruvate for the treatment of cancer

Applicant/Assignee:

Application No.: 11/706868   Filing Date: 14/Feb/2007

Abstract:

This invention provides compositions and methods for the treatment of cancer. An inhibitor cocktail buffer includes at least one sugar, a non-potassium containing buffer, and an inhibitor having the general formula: Such an inhibitor cocktail buffer allows for the efficacious and safe delivery of various compounds, including halopyruvates and derivatives thereof, to human cancer patients.

Priority: US20060773653P Applic. Date: 2006-02-16

Inventor: KO YOUNG HEE [US]

Title: Multi-lamellar liquid crystal emulsion system

Applicant/Assignee:

Application No.: 10/830568   Filing Date: 23/Apr/2004

Abstract:

Topical cosmetic and pharmaceutical oil-in-water emulsions wherein an emulsifier blend, comprising a mixture of at least two sucrose esters in combination with at least one solid fatty alcohol, forms a multi-lamellar liquid crystalline network that effectively moisturizes and protects the skin, and provides a useful vehicle for delivery of active ingredients. Sucrose esters are used in emulsions of the present invention at very low concentrations (from about 0.2 % to about 1.2 % by combined weight of sucrose esters relative to the total weight of the emulsion).

Priority:

Inventor: MERCIER MICHEL F [US]; THAU PAUL [US]; CHASE JOHN [US]

Title: Composition exhibiting enhanced formulation stability and delivery of topical active ingredients

Applicant/Assignee: SOL-GEL TECHNOLOGIES LTD

Application No.: 09/983229   Filing Date: 23/Oct/2001

Abstract:

A therapeutic, cosmetic or cosmeceutic composition for topical application, capable of stabilizing an active ingredient and delivering the active ingredient, comprising a plurality of microcapsules having a core-shell structure. The microcapsules have a diameter of approximately 0.1 to 100 micron. The core of each microcapsule includes at least one active ingredient and is encapsulated within a microcapsular shell. The shell is comprised of at least one inorganic polymer obtained by a sol-gel process, and the shell protects the active ingredient before topical application and is designed to release the active ingredient from the microcapsules following application. The composition is useful in encapsulating active ingredients, such as benzoyl peroxide, that are unstable in other formulation, or are irritating to the skin.

Priority: WO2001IL00370 Applic. Date: 2001-04-20; US20000198749P Applic. Date: 2000-04-21

Inventor: LAPIDOT NOA [IL]; MAGDASSI SHLOMO [IL]; AVNIR DAVID [IL]; ROTTMAN CLAUDIO [IL]; GANS ORIT [IL]; SERI-LEVY ALON [IL]

Title: Skin external agents and drugs

Applicant/Assignee: KANEBO COSTMETICS INC KAO CORPORATION

Application No.: 11/400651   Filing Date: 07/Apr/2006

Abstract:

The present invention provides a method for enhancing epidermal permeability barrier function of the aged skin, which includes the step of externally administering to the aged skin an amount of a fumaric acid diester derivative expressed by the following general formula (1) as an active ingredient wherein R1 represents a C1-4 alkylene group

R2 and R3 each represents a linear or branched C1-8 alkyl group

and n is an integer of 2 to 5.

Priority: JP20000093152 Applic. Date: 2000-03-30; JP20000323637 Applic. Date: 2000-10-24; JP20000341577 Applic. Date: 2000-11-09; US2002-169040 Applic. Date: 2002-06-21; WO2000JP08942 Applic. Date: 2000-12-15

Inventor: UCHIWA HIDEYO [JP]; HIROTSU SACHIYO [JP]; HARATAKE AKINORI [JP]; IKEMOTO TAKESHI [JP]; MATSUI JUNICHI [JP]; YAMAZAKI SHUNSUKE [JP]; YOSHIDA MASAKI [JP]; HAYASE MOTOI [JP]

Title: Composition and method for reducing the appearance of cellulite

Applicant/Assignee:

Application No.: 11/408383   Filing Date: 21/Apr/2006

Abstract:

A topical composition for controlling the metabolism and/or distribution of subcutaneous fat and/or moderating the appearance of cellulite, comprising, as an active ingredient, phosphatidylcholine together with a solvent operative to maintain the phosphatidylcholine in solution, and a buffer which maintains the composition in the range of pH 7.5-9.0. Typically, the composition includes less than 10% by weight water. The composition may include further active ingredients such as xanthines. Also disclosed are methods for using the composition.

Priority: US20050674861P Applic. Date: 2005-04-26

Inventor: KULESZA JOHN [US]

Title: Administration form with active substance-containing particles, for application on the skin or mucosa

Applicant/Assignee: LTS LOHMANN THERAPIE-SYSTEME AG

Application No.: 10/484895   Filing Date: 11/Jul/2002

Abstract:

Administration forms for application to the skin or mucosa, comprising a carrier matrix and at least one active substance, are characterized in that the carrier matrix has a plurality of particles having open pores or containing capillary spaces, said particles serving as active substance reservoir and containing at least one active substance.

Priority: DE20011036784 Applic. Date: 2001-07-27; WO2002EP07716 Applic. Date: 2002-07-11

Inventor: BECHER FRANK [DE]

Title: Skin care compositions and methods

Applicant/Assignee: BIOPHYSICA, INC

Application No.: 12/134762   Filing Date: 06/Jun/2008

Abstract:

Skin care compositions and methods are provided comprising a highly hydrophobic substance, an alkaryl polyfluorocarbon, particularly a substituted phenyl-polyfluoroacylamino propanamide, an alkanol and refined oils and the oil triglyceride fractions in sufficient amount to provide substantial homogeneity. When employed for hirsutism, optionally antioxidants and moisturizer are added. For use against wrinkles, additionally vitamins, antioxidants and a mixture of extracts of naturally occurring substances are present.

Priority: US2006-509485 Applic. Date: 2006-08-24; US20050713882P Applic. Date: 2005-09-01

Inventor: SOVAK MILOS [US]; SELIGSON ALLEN L [US]; PROKOP JIRI [CZ]

Title: Method of treatment of skin with external preparation composition

Applicant/Assignee: LION CORPORATION

Application No.: 12/257853   Filing Date: 24/Oct/2008

Abstract:

An external preparation composition used for preventing or treating symptoms or diseases related to dermatopathy caused by dryness, UV rays and aging such as wrinkles and sags of the skin, pigmentation of the skin, skin roughness and coarse texture and skin diseases such as psoriasis, lichen, ichthyosis, keratosis, Darier's disease, pustulosis, acne, eczema and atopic dermatitis. The external preparation composition comprises at least one of acyl glucosamine derivatives represented by the following Formula (I): wherein R1, R2, R3, R4 and R5 are defined

and X is any one of groups represented by the following Formulas (A) to (C): wherein Y, n and R6 are also defined.

Priority: US2005-522032 Applic. Date: 2005-01-21; WO2002JP07549 Applic. Date: 2002-07-25

Inventor: KAMBAYASHI HIROAKI [JP]; KONTA HIROSHI [JP]

Title: Diarylalkanes as potent inhibitors of binuclear enzymes

Applicant/Assignee: UNIGEN PHARMACEUTICALS, INC

Application No.: 12/027090   Filing Date: 06/Feb/2008

Abstract:

The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds-diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function.

The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

Priority: US2005-139200 Applic. Date: 2005-05-27; US20040575599P Applic. Date: 2004-05-28

Inventor: JIA QI [US]; ZHAO JI-FU [US]

Title: System and method for providing intelligence centers

Applicant/Assignee: ICENTERA CORPORATION

Application No.: 11/145750   Filing Date: 06/Jun/2005

Abstract:

Disclosed herein, among other things, is a system comprising a content repository, a communication portal developer, a content manager, and an analytic engine. The content repository is adapted to store electronic content in a computer-readable storage medium. The communication portal developer includes at least one wizard to create a plurality of customizable portals without coding software. Each customizable portal is accessible to one or more selected visitors through a web browser. The content manager is adapted to publish selectable electronic content to selectable portals. The content manager includes at least one wizard to populate and manage the electronic content within the content repository. The analytic engine analyzes electronic content use and visitor behavior while logged into their customizable portal.

In various embodiments, the analytics are provided in real time or near real time. Other embodiments are disclosed herein.

Priority: US20040577357P Applic. Date: 2004-06-04

Inventor: NELSON CRAIG [US]

Title: Cosmetic composition containing a photochromic colouring agent and its use for skin and/or skin appendage make-up and/or care

Applicant/Assignee: L'OREAL

Application No.: 10/168537   Filing Date: 28/Oct/2002

Abstract:

Liquid cosmetic composition in the form of an emulsion comprising at least two distinct phases and containing at least one photochromic coloring agent and at least one non-photochromic coloring matter, characterized in that the photochromic coloring agent(s) and the non-photochromic coloring matter(s) are located in separate phases of the emulsion. Application to the make-up and/or the care of the skin and/or its appendages.

Priority: FR20000014027 Applic. Date: 2000-10-31; WO2001FR03370 Applic. Date: 2001-10-30

Inventor: KOLODZIEJ RICHARD [FR]; SOISTIER NICOLAS [FR]; SIMON JEAN-CHRISTOPHE [FR]

Title: Liquid cleaning composition comprising at least one anionic surfactant and its use for cleansing human keratin materials

Applicant/Assignee: L'OREAL S.A

Application No.: 11/287300   Filing Date: 28/Nov/2005

Abstract:

The present disclosure relates to a liquid cleansing composition, comprising, in a cosmetically acceptable aqueous medium: (a) at least one anionic surfactant

(b) at least one electrolyte, (c) at least one copolymer of methacrylic acid and of a C1-C4 alkyl acrylate, present in an amount of less than 0.5% by weight of active material, relative to the total weight of the composition. The present disclosure also relates to the use of the compositions in cosmetics or dermatology, such as products for cleansing human keratin materials, for instance the skin, and to their use for improving the stability of the texture of the composition at low temperature.

Priority: FR20040052780 Applic. Date: 2004-11-26; US20040634542P Applic. Date: 2004-12-10

Inventor: BISSEY-BEUGRAS LAURE [FR]; RIBERY DELPHINE [FR]

Title: Water-in-oil emulsion foundation

Applicant/Assignee: L'OREAL S.A

Application No.: 10/603698   Filing Date: 26/Jun/2003

Abstract:

A foundation in the form of a water-in-oil emulsion comprising a fatty phase, an aqueous phase, at least one surfactant chosen from C8-C22 alkyl dimethicone copolyols, at least one other surfactant chosen from dimethicone copolyols, and hydrophobic coated pigments, where the fatty phase comprises at least 30% by weight, relative to the total weight of the emulsion, of a volatile fatty phase comprising: at least 6% by weight, relative to the total weight of the emulsion, of at least one volatile hydrocarbon oil, and at least one volatile oil chosen from silicone volatile oils and fluorinated volatile oils

wherein the foundation is stable after storing at room temperature (25 DEG C.) for at least 2 months and makes it possible to obtain a homogeneous make-up on the skin.

Priority: FR20020007937 Applic. Date: 2002-06-26; FR20020012190 Applic. Date: 2002-10-02; US20020401028P Applic. Date: 2002-08-06

Inventor: GARDEL NADIA [FR]; BARROIS VERONIQUE [FR]

Title: Organo-gel formulations for therapeutic applications

Applicant/Assignee: MEDIQUEST THERAPEUTICS, INC

Application No.: 11/246296   Filing Date: 11/Oct/2005

Abstract:

A composition suitable for the local delivery of cosmetic and/or pharmaceutical agents into the skin containing at least two biocompatible organic solvents, a polar lipid, a surfactant, water, urea and a thickener wherein the organic solvents include an ester and a dihydric and/or polyhydric alcohol is provided. Also disclosed are compositions that further contain a cosmetic and/or pharmaceutical agent, along with the preparation and use thereof.

Priority: US2005-150254 Applic. Date: 2005-06-13; US2005-066485 Applic. Date: 2005-02-28; US2004-960516 Applic. Date: 2004-10-08

Inventor: DECHOW FREDERICK J [US]

Title: Composition based on natural extracts useful in the prevention and treatment of cutaneous wrinkles

Applicant/Assignee: CETERIS HOLDING B.V. - AMSTERDAM (OLANDA) - SUCCURSALE DI LUGANO

Application No.: 10/257869   Filing Date: 12/Oct/2000

Abstract:

A composition based on natural extracts useful in the prevention and treatment of cutaneous ageing and particularly wrinkles, which comprises in combination: leucocyanadines in the form of extract of Vitis vinifera

triterpenes in the form of an extract of Centella asiatica

fish cartilage extract.

Priority: CH20000000776 Applic. Date: 2000-04-18; WO2000EP10276 Applic. Date: 2000-10-12

Inventor: BERARDESCA ENZO [IT]

Title: Film-forming cosmetic composition

Applicant/Assignee: L'OREAL S.A

Application No.: 10/478322   Filing Date: 14/Jun/2004

Abstract:

The present disclosure relates to a cosmetic composition comprising, in an aqueous medium, at least one film-forming polymer, at least one aqueous microdispersion of wax, and at least one water-soluble aromatic acid ester that is liquid at room temperature. The present disclosure also relates to the process for cosmetically treating keratinous materials, such as the skin, comprising applying said composition to keratinous materials. The composition is easy to apply on keratinous materials and forms a glossy and non-sticky film.

Priority: FR20010006657 Applic. Date: 2001-05-21; WO2002FR01705 Applic. Date: 2002-05-21

Inventor: COLLIN NATHALIE [FR]; OLIVIER SANDRINE [FR]

Title: High Sunscreen Efficiency Water-in-Oil Emulsion

Applicant/Assignee:

Application No.: 12/084908   Filing Date: 13/Nov/2006

Abstract:

The present invention relates to highly stable water-in-oil sunscreen emulsions that provide a high sunscreen efficiency ("SE") having a sun protection factor ("SPF") of X, where X is at least about 15, and having a sunscreen efficiency ("SE") of at least 2, preferably at least 3, where SE is the ratio of SPF over the total weight percentage of sunscreen actives based on the total weight of the composition. The emulsions of the present invention provide photoprotection for the period corresponding to the labeled SPF throughout the period of exposure to natural sunlight and comprises (i) at least one sunscreen active and (ii) an alkyl dimethicone copolyol emulsifier in which the water-soluble, alkyl-soluble and silicone-soluble groups of the dimethicone copolyol are in specific ratios to each other.

Preferably, the high SE water-in-oil emulsion comprises both a UV-A sunscreen and UV-B sunscreen. More preferably, the combination of sunscreen actives is photostable.

Priority: US20050737048P Applic. Date: 2005-11-14; WO2006US44110 Applic. Date: 2006-11-13

Inventor: LOTT DENNIS [US]; LEWELLEN KELLY [US]; WIENER GLENN [US]

Title: Strain Of Turkey Tail Mushroom, Extract From The Same, And Use Of The Same

Applicant/Assignee: NIKKEN SOHONSHA CORPORATION

Application No.: 11/996961   Filing Date: 28/Jul/2006

Abstract:

The present invention provides a new strain of turkey tail mushroom (Trametes versicolor (L.: Fr.) Pilat) having excellent biological activities (Accession number: FERM BP-10633). The strain is excellent in platelet aggregation inhibitory effect, chemokine gene expression inhibitory effect, antimutagenic effect, antitumor effect, antihypertensive effect, and immunomodulatory effect. The effect of the strain is enhanced synergistically by combining with microalgae and other basidiomycetes. The turkey tail mushroom of the present invention has high safety, and a possibility that a side effect is caused because of long-term continuous use is very low. Thus, it is useful for food/drink, cosmetics, pharmaceuticals or the like, the objective of which is the prevention and improvement in inflammation, allergy, tumor, and other diseases. The turkey tail mushroom strain of the present invention has very high hyphal growth property and very high physiological functions compared with conventional strains

therefore, it can be used stably.

Priority: JP20050218554 Applic. Date: 2005-07-28; WO2006JP314978 Applic. Date: 2006-07-28

Inventor: EGUCHI FUMIO [JP]; SUMI RYO [JP]; MORI NOBUO [JP]

Title: Dipeptidyl peptidase inhibitors

Applicant/Assignee: SYRRX, INC TAKEDA PHARMACEUTICAL COMPANY LIMITED

Application No.: 10/934326   Filing Date: 02/Sep/2004

Abstract:

Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.

Priority: US20030501458P Applic. Date: 2003-09-08

Inventor: CAO SHELDON X [US]; FENG JUN [US]; GWALTNEY STEPHEN L [US]; KALDOR STEPHEN W [US]; STAFFORD JEFFREY A [US]; WALLACE MICHAEL B [US]; XIAO XIAO-YI [US]; ZHANG ZHIYUAN [US]

Title: SILANE ESTERS AND AMIDES OF 2-OXOTHIAZOLIDINE-4-CARBOXYLIC ACID, AND COSMETIC USES THEREOF

Applicant/Assignee: L'OREAL

Application No.: 11/577600   Filing Date: 27/Sep/2005

Abstract:

The present invention relates to novel compounds of formula (1) and also to cosmetic compositions containing them and to the cosmetic uses thereof, in particular for protecting the skin against UV-induced oxidative stress.

Priority: FR20040052399 Applic. Date: 2004-10-21; US20040632541P Applic. Date: 2004-12-03; WO2005EP12032 Applic. Date: 2005-09-27

Inventor: LUCET-LEVANNIER KARINE [FR]

Title: Cosmetic and/or dermatological use of a composition comprising at least one oxidation-sensitive hydrophilic active principle stabilized by at least one maleic anhydride copolymer

Applicant/Assignee: L'OREAL

Application No.: 10/424907   Filing Date: 29/Apr/2003

Abstract:

A method for depigmenting and/or lightening the skin and/or hair, including body hair, including applying a composition including at least one oxidation-sensitive hydrophilic active principle chosen from ascorbic acid and its derivatives and at least one maleic anhydride copolymer, comprising one or more maleic anhydride comonomers and one or more comonomers chosen from vinyl acetate, vinyl alcohol, vinylpyrrolidone, olefins comprising from 2 to 20 carbon atoms, and styrene, in a physiologically acceptable medium comprising an aqueous phase, to the skin and/or hair.

Priority: FR20020007638 Applic. Date: 2002-06-20; US20020394255P Applic. Date: 2002-07-09

Inventor: BIATRY BRUNO [FR]

Title: pH-sensitive mucoadhesive film-forming gels and wax-film composites suitable for topical and mucosal delivery of molecules

Applicant/Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION

Application No.: 09/748133   Filing Date: 27/Dec/2000

Abstract:

The present invention relates to pH-sensitive mucoadhesive film-forming gels and wax-film composites suitable for topical and mucosal delivery of molecules of interest, namely active pharmaceuticals. The gels comprise a pharmaceutically acceptable pH-sensitive polymer that responds to a lowering of pH by precipitating into films when in contact with the skin or mucosal surface. The films also comprise an adhesive polymer that allows the film to remain in contact with the tissue for an extended period of time. The wax-film composites comprise a bi-layer film having both the said pH-sensitive mucoadhesive layer to promote strong adherence to the skin and mucosal surfaces as well as a specially bonded wax layer intended to extend the adherence of the film to tissues for a prolonged period of time.

The invention also relates to the use of said pH-sensitive film-forming gels and wax-film composites to deliver molecules of interest, such as small molecules, peptides, proteins, and nucleic acids either locally to act at the site of administration or for the absorption of said molecules of interest across biological membranes into the systemic circulation.

Priority:

Inventor: MUMPER RUSSELL [US]; JAY MICHAEL [US]

Title: Antigenic HIV gp41 chimeric polypeptides comprising the MVP5180/91 epitope SKGKLIS

Applicant/Assignee: DADE BEHRING MARBURG GMBH SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBH

Application No.: 11/084858   Filing Date: 21/Mar/2005

Abstract:

Immunologically active peptides which are derived from a novel immunodeficiency virus which has the designation MVP5180/91 are described. A diagnostic composition containing such a peptide and methods of detecting an antibody against a retrovirus that causes immune deficiency using such diagnostic composition are also described. A kit containing the immunologically active peptides is also described. An immunogen and method of immunizing a mammal against HIV infection using the immunologically active peptides is described. DNA encoding the peptides and methods of detecting nucleic acids encoding HIV viruses are also described.

Priority: DE19944405810 Applic. Date: 1994-02-23; US2001-000321 Applic. Date: 2001-12-04; US1998-131551 Applic. Date: 1998-08-10; US1995-394021 Applic. Date: 1995-02-23

Inventor: BRUST STEFAN [DE]; KNAPP STEFAN [DE]; GERKEN MANFRED [DE]; GUERTLER LUTZ G [DE]

Title: Antimicrobial Peptides Derived From Cap18

Applicant/Assignee: OCTOPLUS TECHNOLOGIES B.V ACADEMISCH ZIEKENHUIS LEIDEN

Application No.: 11/658415   Filing Date: 26/Jul/2005

Abstract:

The invention provides methods to exert antimicrobial effects in prophylactic or therapeutic treatment of bacterial or fungal infections employing polypeptides that have affinity to microbial and fungal toxins.

Priority: EP20040077175 Applic. Date: 2004-07-28; WO2005NL00545 Applic. Date: 2005-07-26

Inventor: GROTE JOHANNES JAKOBUS [NL]; DRIJFHOUT JAN WOUTER [NL]; HIEMSTRA PIETER SICCO [NL]; VONK MARCEL JAN [NL]; NELL MAARTJE JOHANNA [NL]; BLOEMBERG GUIDO VINCENT [NL]

Title: Intravenous delivery of polynucleotides to cells in mammalian limb

Applicant/Assignee: ROCHE MADISON INC

Application No.: 10/855175   Filing Date: 27/May/2004

Abstract:

An intravenous delivery method is described that enables delivery of polynucleotides to extravascular cells of a mammalian limb. The method involves the injection of polynucleotides into a distal vein of a limb that is transiently occluded. Polynucleotide delivery is facilitated by rapid injection in sufficient volume to enable extravasation of the solution into surrounding tissue.

Priority: US20030473654P Applic. Date: 2003-05-28; US20030500211P Applic. Date: 2003-09-04

Inventor: HAGSTROM JAMES E [US]; HEGGE JULIA [US]; HERWEIJER HANS [US]; WOLFF JON A [US]

Title: Anti-Inflammatory Compounds

Applicant/Assignee: NEW ZEALAND INSTITUTE FOR CROP & FOOD RESEARCH LIMITED NATIONAL INSTITUTE OF WATER AND ATMOSPHERIC RESEARCH LIMITED MALAGHAN INSTITUTE OF MEDICAL RESEARCH

Application No.: 11/663157   Filing Date: 16/Sep/2005

Abstract:

Compounds of formula (I) or formula (II) have anti-inflammatory activity and comprise a new class of NSAIDs. The compounds are useful for treating inflammatory diseases or disorders. The invention also provides pharmaceutical compositions containing these compounds, as well as methods of treating inflammatory diseases or disorders using compounds of formula (III) or formula (IV).

Priority: NZ20040535383 Applic. Date: 2004-09-17; WO2005NZ00246 Applic. Date: 2005-09-16

Inventor: DENNY WILLIAM ALEXANDER [NZ]; COPP BRENT RAYMOND [NZ]; PEARCE ALLISON NORRIE [NZ]; BERRIDGE MICHAEL VIVIAN [NZ]; HARPER JACQUIE LUCILLE [NZ]; PERRY NIGEL BRIAN [NZ]; LARSEN LESLEY [NZ]; GODFREY COLETTE AMIRAH [AU]

Title: MEDICINAL ACIDIC CANNABINOIDS

Applicant/Assignee: NEDERLANDSE ORGANISATIE VOOR TOEGEPASTNATUURWETENSCHAPPELIJK ONDERZOEK TNO NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO

Application No.: 11/461818   Filing Date: 02/Aug/2006

Abstract:

The invention relates to an acidic cannabinoid for medical use and to a cannabis extract comprising an acidic cannabinoid. The extract may comprise one or more compounds selected from the group consisting of cannabidiolic acid (CBD-A), cannabidiol (CBD), cannabigerolic acid (CBGA), cannabigerol (CBG), cannabinolic acid (CBN-A) and cannabinol. The invention further relates to a method for preparing a preparation comprising extracting an acidic cannabinoid from cannabis.

Priority: EP20040075300 Applic. Date: 2004-02-02; WO2005NL00075 Applic. Date: 2005-02-02

Inventor: KORTHOUT HENRICUS ADRIAAN A J [NL]; VERHOECKX KITTY CATHARINA M [NL]; WITKAMP RENTJE FREDERIK [NL]; DOORNBOS ROBERT PAUL [NL]; WANG MEI [NL]

Title: Crosslinked oil droplet-based cosmetic or pharmaceutical emulsions

Applicant/Assignee: BEIERSDORF AG

Application No.: 10/953587   Filing Date: 28/Sep/2004

Abstract:

The invention is a crosslinked water-in-oil emulsion that is useful in cosmetic and pharmaceutical applications. The emulsion includes a water phase, oil phase, water-in-oil emulsifier, and one or more crosslinkers. The crosslinkers that are useful in the invention include molecules having at least one hydrophilic region and at least one hydrophobic region. The invention also includes a process for preparing the crosslinked emulsion.

Priority: DE20021013956 Applic. Date: 2002-03-28; WO2003EP03167 Applic. Date: 2003-03-27

Inventor: SCHREIBER JOERG [DE]; DIEC KHIET HIEN [DE]

Title: SOLUBLE PATCH

Applicant/Assignee: L'OREAL

Application No.: 12/169779   Filing Date: 09/Jul/2008

Abstract:

An article, preferably a patch, containing: a support in the form of at least one sheet containing fibres that are water-soluble at a temperature of 0-30 DEG C., and a composition carried by the support, containing at least one water-soluble gelling agent which swells in less than 30 seconds in water at a temperature of 20 DEG C. to 30 DEG C.

Priority: FR20050053752 Applic. Date: 2005-12-07; US2006-567336 Applic. Date: 2006-12-06; US20050752051P Applic. Date: 2005-12-21

Inventor: AUBRUN-SONNEVILLE ODILE [FR]

Title: Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using [alpha]1-adrenoceptor agonists

Applicant/Assignee: VICEPT THERAPEUTICS, INC

Application No.: 10/763807   Filing Date: 22/Jan/2004

Abstract:

The present invention is directed to the treatment of skin erythema as exhibited in rosacea and other conditions characterized by increased erythema (redness) of the skin. These conditions exhibit dilation of blood vessels due to a cutaneous vascular hyper-reactivity. In particular, the present invention is directed to a novel composition and method for the treatment of skin erythema using [alpha]1-adrenergic receptor ([alpha]1-adrenoceptor) agonists incorporated into cosmetic, pharmacological or dermatological compositions for topical application to the skin.

Priority:

Inventor: SHANLER STUART D [US]; ONDO ANDREW [US]

Title: Cosmetic compositions

Applicant/Assignee: MOLECULAR RESEARCH CENTER, INC

Application No.: 10/925851   Filing Date: 25/Aug/2004

Abstract:

A composition and method for improving skin appearance by reducing skin redness and symptoms associated with skin inflammation, irritation and skin aging by topically treating skin is disclosed. In this composition and method, an active material having the formula given below is applied to the patient at the site of said condition: wherein R1 is selected from -OH and C1-C3 alkyl OH

and R2, R3, R4, R5 and R6 are independently selected from -H, -OH, C1-C6 alkyl, and C3-C6 cycloalkyl. The active material should contain no more than five -OH groups. Preferred active materials include 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, 1,2,3-cyclohexanetriol, 1,3,5-cyclohexanetriol, and mixtures of those materials. A method of maintaining healthy hair and reducing hair loss using these actives is also disclosed.

Priority:

Inventor: CHOMCZYNSKI PIOTR [US]

Title: Method of Obtaining a Firming Active Principle, Active Principle Thus Obtained and Uses Thereof

Applicant/Assignee: SOCIETE INDUSTRIELLE LIMOUSINE D'APPLICATION BIOLOGIQUE SILAB

Application No.: 11/661808   Filing Date: 25/Aug/2005

Abstract:

The invention relates to a method of obtaining a firming active principle resulting from the solubilization of Cucurbita pepo seed meal treated by means of enzymatic hydrolysis. The invention also relates to the active principle thus obtained and to the uses thereof in cosmetics.

Priority: FR20040051951 Applic. Date: 2004-09-01; WO2005FR50685 Applic. Date: 2005-08-25

Inventor: PAUFIQUE JEAN [FR]

Title: 5,6-Diphenyl-1,2,4-Triazinic Dimeric Derivatives and the Use Thereof in the Form of Sun-Protective Agents

Applicant/Assignee: PIERRE FABRE DERMO-COSMETIQUE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) UNIVERSITE CLAUDE BERNARD LYON 1

Application No.: 11/579538   Filing Date: 04/May/2005

Abstract:

The invention relates to 5,6-diphenyl-1,2,4-triazinic compounds of general formula (I), wherein identical or different R1, R2, R3 and R4 represent a hydrogen, fluoride, chloride or bromine atom, C1 to C12 linear or branched alkyl, C1 A C18 linear or branched hydroxy, alkoxy poly(ethoxy)-alkoxy with a C1 to C4 alkyl fragment and an ethoxy number ranging from 1 to 4, amino or mono or di-alkylamino with a C1 to C4 alkyl fragment group, X is ortho-, meta- or paraphenylene, 4,4'-biphenylene, 2,4- or 2,6- or 3,4- or 3,5-pyridinylene, 2,2'-bipyridinylene, meta- or paraphenylenediamino, ethylenediamine, 2,2'-piperazinylene, diacyl of formula -(R4CO)2-, wherein r represents a phenyl radical, a 3 to 10 carbon, phenanthrene or anthracene atoms alkyl chain except 1,4-bis(5,6-diphenyl-1,2,4-triazin-3-yl)benzene of 2,4-bis(5,6-diphenyl-1,2,4-triazin-3-yl)pyridine and of 2,6-bis(5,6-diphenyl-1,2,

4-triazin-3-yl)pyridine, to cosmetic compositions containing said compounds and to the use thereof in the form of sun filters or light-protective agents.

Priority: FR20040004811 Applic. Date: 2004-05-05; WO2005FR01132 Applic. Date: 2005-05-04

Inventor: PICOUL WILLY [FR]; CIUFOLINI MARCO [CA]; BORDAT PASCAL [FR]; TARROUX ROGER [FR]

Title: Oleaginous pharmaceutical and cosmetic foam

Applicant/Assignee: FOAMIX LTD

Application No.: 10/835505   Filing Date: 28/Apr/2004

Abstract:

The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent selected from a hydrophobic solvent, a silicone oil, an emollient, a co-solvent, and mixtures thereof, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition

at least one gelling agent at a concentration of about 0.1% to about 5% by weight of the total composition

a therapeutically effective amount of at least one active agent

and at least one liquefied or compressed gas propellant, at a concentration of about 3% to about 25% by weight of the total composition.

Priority: US20030530015P Applic. Date: 2003-12-16; US20030492385P Applic. Date: 2003-08-04

Inventor: TAMARKIN DOV [IL]; FRIEDMAN DORON [IL]; EINI MEIR [IL]; BESONOV ALEX [IL]

Title: MODIFIED SORBITAN SILOXANE COMPOSITIONS AND USE THEREOF

Applicant/Assignee: KIMBERLY-CLARK WORLDWIDE, INC

Application No.: 11/934567   Filing Date: 02/Nov/2007

Abstract:

The present disclosure generally relates to personal care compositions and wipes. More particularly, the disclosure relates to compositions and wipes for imparting a perceivable aesthetic feel to the skin of a user. To achieve the perceivable aesthetic feel, a modified sorbitan siloxane is incorporated into the compositions and wipes.

Priority:

Inventor: CUNNINGHAM COREY [US]; WENZEL SCOTT W [US]; LANGOLF BRIAN M [US]; KIEFFER PHILIP E [US]; DECKER CHRISTOPHER V [US]

Title: Ampholytic anionic copolymers

Applicant/Assignee: BASF AKTIENGESELLSCHAFT BASF SE

Application No.: 10/582227   Filing Date: 08/Dec/2004

Abstract:

Ampholytic copolymers which contain a molar excess of anionogenic and/or anionic groups, polyelectrolyte complexes which contain such an ampholytic copolymer, cosmetic and pharmaceutical compositions which contain at least one such copolymer or polyelectrolyte complex and the use of these copolymers and polyelectrolyte complexes are described.

Priority: DE20031057487 Applic. Date: 2003-12-09; WO2004EP13983 Applic. Date: 2004-12-08

Inventor: NGUYEN-KIM SON [DE]; MATHAUER KLEMENS [DE]; WOOD CLAUDIA [DE]; SCHUH GERD [DE]; PATWARDHAN DARSHAN [DE]

Title: Anhydrous cosmetic compositions comprising at least one polymeric gelling agent, at least one non-volatile oil, and poly(methyl methacrylate) particles

Applicant/Assignee: L'OREAL S.A

Application No.: 11/099556   Filing Date: 06/Apr/2005

Abstract:

The present disclosure relates to anhydrous compositions for making up or caring for the skin, for example foundations, comprising at least one liquid organic phase comprising at least one non-volatile oil, at least one amorphous gelling polymer formed by polymerization of an olefin, and poly(methyl methacrylate) particles, wherein the amount of the at least one non-volatile oil present in the composition is greater than the amount of poly(methyl methacrylate) particles present in the composition. The compositions may exhibit a smooth and melting creamy texture, spread easily over the skin, and make it possible to obtain a homogeneous make-up that has a powdery and matt finish and that confers a pleasant softness on the skin. The make-up may also exhibit good properties of hold.

Priority: FR20040050695 Applic. Date: 2004-04-06; US20040569629P Applic. Date: 2004-05-11

Inventor: MARTIN GUENAELLE [FR]; THEMENS AGNES [FR]

Title: Foamable pharmaceutical compositions and methods for treating a disorder

Applicant/Assignee: STIEFEL LABORATORIES, INC

Application No.: 11/595864   Filing Date: 13/Nov/2006

Abstract:

Novel compositions of matter comprising a foamable delivery system are provided. Novel methods for treating a disease, disorder, or condition using the novel compositions are further provided. Novel methods for making and delivering a foamable pharmaceutical composition are also provided. While the novel compositions and foamable drug delivery system may be utilized for administration of a wide variety of drugs to epithelial tissues, to treat a wide variety of diseases, disorders, or conditions, the inventive compositions and foamable drug delivery systems are particularly useful for the dermatological administration of corticosteroids and antifungal agents.

Priority: US2003-445487 Applic. Date: 2003-05-28

Inventor: POPP KARL F [US]; YUHAS EDWARD R [US]

Title: GLUTAMINE-CONTAINING COMPOSITIONS AND A METHOD FOR INCREASING BLOOD FLOW USING SAME

Applicant/Assignee: AJINOMOTO CO., INC

Application No.: 12/414037   Filing Date: 30/Mar/2009

Abstract:

The present invention provides a glutamine-containing composition which functions to increase blood flow. Glutamine is present in the composition in an amount of 25 mg/kg body weight to 150 mg/kg body weight. By administering the composition to a subject in need thereof, the blood flow in the capillary vessels can be efficiently increased, while inhibiting any side effects such as low blood pressure. The present invention also provides food or feed containing the composition for increasing blood flow.

Priority: JP20060266544 Applic. Date: 2006-09-29; WO2007JP68988 Applic. Date: 2007-09-28

Inventor: OHTA FUMIO [JP]; TAKAGI TOMO [JP]; SATO HIROYUKI [JP]

Title: ENCAPSULATED ACTIVE MATERIAL CONTAINING NANOSCALED MATERIAL

Applicant/Assignee: INTERNATIONAL FLAVORS & FRAGRANCES INC

Application No.: 11/611501   Filing Date: 15/Dec/2006

Abstract:

The present invention is directed to novel capsules containing active material and nanoscaled material and to methods for making capsules with enhanced performance and stability. The capsules are well suited for use in personal care applications, laundry products and perfume and fragrance products.

Priority:

Inventor: LEI YABIN [US]; POPPLEWELL LEWIS MICHAEL [US]; JOYCE CAROL [US]

Title: ADMINISTRATION OF 6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTOIC ACID FOR THE TREATMENT OF DERMATOLOGICAL DISORDERS

Applicant/Assignee: GALDERMA RESEARCH & DEVELOPMENT

Application No.: 12/437008   Filing Date: 07/May/2009

Abstract:

Dermatological disorders having an inflammatory or proliferative component are treated with pharmaceutical compositions containing on the order of 0.3% by weight of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthanoic acid (adapalene) or salt thereof, formulated into pharmaceutically acceptable media therefor, advantageously topically applicable gels, creams or lotions.

Priority: FR20020003070 Applic. Date: 2002-03-12; US2004-937612 Applic. Date: 2004-09-10; WO2003EP03246 Applic. Date: 2003-03-12; US20020370223P Applic. Date: 2002-04-08

Inventor: GRAEBER MICHAEL [US]; CZERNIELEWSKI JANUSZ [FR]

Title: Method of microencapsulation

Applicant/Assignee: TAGRA BIOTECHNOLOGIES LTD

Application No.: 11/208007   Filing Date: 22/Aug/2005

Abstract:

The present invention provides methods for microencapsulation of active ingredients for topical application, whereby double-layer and triple-layer microcapsules are obtained. The microcapsules protect the active ingredients, maintain their original activity throughout processing, formulation and storage, and enable controlled release of the active ingredient only upon application onto the skin.

Priority: GB19990027202 Applic. Date: 1999-11-17; US2002-130529 Applic. Date: 2002-09-30; WO2000IL00759 Applic. Date: 2000-11-16

Inventor: KVITNITSKY EMMA [IL]; SHAPIRO YURY [IL]; PRIVALOV OLGA [IL]; OLEINIK IRENA [IL]; POLISHER IGOR [IL]

Title: Coumermycin/novobiocin-regulated gene expression system

Applicant/Assignee: ZHAO,HUI-FEN,SHEN, SHI-HSIANG NATIONAL RESEARCH COUNCIL OF CANADA

Application No.: 10/559411   Filing Date: 09/Jun/2004

Abstract:

A chimeric transactivator comprises a transcription activation domain, a repressor protein DNA binding domain and the bacterial DNA gyrase B subunit. A target gene is operatively linked to operator DNA sequences recognized by the repressor binding domain. The addition of the antibiotic coumermycin results in a coumermycin-switched dimerization of the transactivator, which then binds to operator DNA sequences and activates transcription of the target gene. The addition of novobiocin switches off expression of the target gene by abolishing coumermycin-induced dimerization of the transactivator.

Priority: US20030477055P Applic. Date: 2003-06-10; WO2004CA00854 Applic. Date: 2004-06-09

Inventor: ZHAO HUI-FEN [CA]; SHEN SHI-HSIANG [CA]

Title: Compounds, formulations, and methods for ameliorating telangiectasias

Applicant/Assignee: SANSROSA PHARMACEUTICAL DEVELOPMENTS, INC GALDERMA LABORATORIES INC

Application No.: 11/449079   Filing Date: 08/Jun/2006

Abstract:

Methods, compounds, and topical formulations for treatment of telangiectasias are disclosed. The methods comprise topically applying a composition comprising an [alpha]-adrenergic receptor agonist to telangiectatic skin. Amelioration of telangiectasia symptoms begins within minutes after topical application of a disclosed composition. A single application can significantly lessen telangiectasia discoloration for at least about 2 hours.

Priority: US2004-853585 Applic. Date: 2004-05-25; US20030473611P Applic. Date: 2003-05-27

Inventor: DEJOVIN JACK A [US]; DEJOVIN ISABELLE JEAN [US]; POWALA CHRISTOPHER [US]

Title: Dosage control electrode for iontophoresis device

Applicant/Assignee: TRAVANTI PHARMA INC

Application No.: 10/545761   Filing Date: 15/Aug/2005

Abstract:

An electrode assembly for use in an iontophoresis device for the transcutaneous administration of an active therapeutic species has a base layer of including a linking conductive base material which is consumed (oxidizes or reduces) preferentially to water, a first upper layer of sacrificial material coated on a first portion of the base layer wherein the sacrificial material is consumed preferentially to the linking conductive base material of the base layer. A second upper layer of non-conducting material is coated on a second portion of the base layer, the second upper layer being spaced from the first upper layer, connected by a narrow exposed linking area of the base layer material remaining exposed therebetween. During operation of an associated iontophoresis device, the sacrificial material will be sequentially consumed

the first upper layer will be fully consumed followed by the linking conductive base material of the exposed linking area of the base layer which severs the base layer thereby breaking circuit continuity disabling activity in the device. A visual indicator may be provided allowing a wearer to monitor the state of reaction of the linking area.

Priority: US2003-371532 Applic. Date: 2003-02-21; WO2003US31373 Applic. Date: 2003-10-02

Inventor: ANDERSON CARTER R [US]; MORRIS RUSSELL L [US]

Title: SOLUBILIZING SYSTEMS FOR FLAVORS AND FRAGRANCES

Applicant/Assignee: FIRMENICH SA

Application No.: 12/643269   Filing Date: 21/Dec/2009

Abstract:

The present invention provides compositions and clear oil-in-water microemulsion containing up to 80% w/w of an oil, a surfactant system, a w/w oil/surfactant system ratio between 1 and 3, and a solubilizing-aid ingredient which is not a surfactant neither a VOC compound, the latter being present in an amount sufficient to ensure that the ratio oil/(surfactant+solubilizing aid) is comprised between 0.1 and 5. The present invention concerns also the articles and products associated the compositions and microemulsions, and the methods to manufacture them.

Priority: EP20040105185 Applic. Date: 2004-10-20; US2007-689635 Applic. Date: 2007-03-22; WO2005IB03329 Applic. Date: 2005-10-19; US2005-245704 Applic. Date: 2005-10-06; WO2004IB01473 Applic. Date: 2004-04-19; US2003-421216 Applic. Date: 2003-04-21; US20040620557P Applic. Date: 2004-10-20

Inventor: VLAD FLORIN JOSEPH [US]; MOUNIER REMY [FR]; WONG KENNETH [CH]; DAUGERON JOUAULT AUDE [FR]; HERD THOMAS [US]

Title: WET WIPES DISPENSING SYSTEM

Applicant/Assignee: KIMBERLY-CLARK WORLDWIDE, INC

Application No.: 12/267007   Filing Date: 07/Nov/2008

Abstract:

The present disclosure relates to wet wipe dispensing systems for dispensing wet wipes capable of changing temperature upon use. In one embodiment, the dispensing system includes a wet wipe container and a lotion container that is held in assembly with the wet wipe container that contains a lotion that is kept separate from the wet wipes until the wet wipe is dispensed from the wet wipe container. The lotion includes a microencapsulated delivery vehicle that contains a temperature change agent that is capable of generating a temperature change upon contact with an aqueous solution. Once the wet wipe is dispensed from the system, an applicating device can apply the lotion to the wet wipe to facilitate contact between the temperature change agent in the microencapsulated delivery vehicle and the aqueous solution of the wet wipe.

Priority: US2006-420993 Applic. Date: 2006-05-30

Inventor: AMUNDSON JOHN DAVID [US]; ABUTO FRANK P [US]; CLARE TIMOTHY P [US]; FOLEY EDWARD JOHN [US]; WINDER ERIC MICHAEL [US]; SCHMIDT PAUL R [US]; JOSEPH WAEL R [US]; MCDONALD DUANE LYLE [US]

Title: Broad spectrum preservation blends

Applicant/Assignee: ARCH CHEMICALS, INC

Application No.: 11/224397   Filing Date: 12/Sep/2005

Abstract:

A composition having effective broad spectrum preservation activity comprising a mixture of caprylyl glycol or one or more analogs thereof, or mixtures thereof with a preservative selected from the group consisting of: (1) chloroxylenol and 2-phenoxyethanol, (2) chloroxylenol and chlorphenesin, (3) chlorphenesin and 2-phenoxyethanol, and (4) chloroxylenol, chlorphenesin and 2-phenoxyethanol.

Priority: US20040610772P Applic. Date: 2004-09-16

Inventor: CICCOGNANI DIANA T [US]; DINICOLA KEVIN N [US]; HINDEN STEPHEN D [US]; ROBERTS KATHERINE P [US]

Title: MN Gene and Protein

Applicant/Assignee: INSTITUTE OF VIROLOGY OF THE SLOVAK ACADEMY OF SCIENCES

Application No.: 11/932997   Filing Date: 31/Oct/2007

Abstract:

Identified herein is the location of the MN protein binding site, and MN proteins/polypeptides that compete for attachment to vertebrate cells with immobilized MN protein. Such MN proteins/polypeptides prevent cell-cell adhesion and the formation of intercellular contacts. The MN protein binding site is a therapeutic target that can be blocked by organic or inorganic molecules, preferably organic molecules, more preferably proteins/polypeptides that specifically bind to that site. Therapeutic methods for inhibiting the growth of preneoplastic/neoplastic vertebrate cells that abnormally express MN protein are disclosed. Vectors are provided that encode the variable domains of MN-specific antibodies and a flexible linker polypeptide separating those domains.

Further vectors are disclosed that encode a cytotoxic protein/polypeptide operatively linked to the MN gene promoter or a MN gene promoter fragment comprising the HIF-1 consensus binding sequence, and which vectors preferably further encode a cytokine. The MN gene promoter is characterized, and the binding site for a repressor of MN transcription is disclosed. Further, the hypoxia inducibility of the MN gene and the uses of such inducibility are disclosed.

Priority: US2006-356568 Applic. Date: 2006-02-17; US2002-319003 Applic. Date: 2002-12-13; US20010341036P Applic. Date: 2001-12-13

Inventor: HARRIS ADRIAN L [GB]; RATCLIFFE PETER J [GB]

Title: Copolymers based on tert-butyl(meth) acrylate and use thereof

Applicant/Assignee: BASF AKTIENGESELLSCHAFT BASF SE

Application No.: 10/581884   Filing Date: 08/Dec/2004

Abstract:

Copolymers which contain tert-butyl (meth)acrylate, at least one [alpha],[beta]-ethylenically unsaturated amido-containing compound and acrylic acid incorporated in the form of polymerized units, cosmetic and pharmaceutical compositions which contain at least one such copolymer and the use of these copolymers are described.

Priority: DE20031057486 Applic. Date: 2003-12-09; WO2004EP13984 Applic. Date: 2004-12-08

Inventor: NGUYEN-KIM SON [DE]; WOOD CLAUDIA [DE]

Title: Water-in-oil emulsion foundation

Applicant/Assignee: L'OREAL S.A

Application No.: 10/426630   Filing Date: 01/May/2003

Abstract:

A foundation composition in the form of a water-in-oil emulsion comprising a fatty phase

an aqueous phase

at least one silicone surfacant chosen from C8-C22 alkyl dimethicone copolyols

and at least 5% by weight, relative to the total weight of the composition, of hydrophobic coated pigments

provided that the composition is free of polyglyceryl-4 isostearate or comprises polyglyceryl-4 isostearate in a quantity such that the weight ratio of the C8-C22 alkyl dimethicone copolyol to the polyglyceryl-4 isostearate is greater than or equal to 2:1, wherein the foundation composition can exhibit good stability at room temperature and can be easy to apply to the skin.

Priority: FR20020005512 Applic. Date: 2002-05-02; US20020393115P Applic. Date: 2002-07-03

Inventor: SIMONNET JEAN-THIERRY [FR]; VERLOO AURORE [FR]; OZEE EMMANUELLE [FR]

Title: Medicament for the treatment of viral skin and tumour diseases

Applicant/Assignee: MEDIGENE AG

Application No.: 10/495889   Filing Date: 24/Sep/2004

Abstract:

The invention relates to a medicament containing a compound of general formula (1), where R1=independently, a straight or branched, saturated, singly- or multiply-unsaturated, optionally substituted C11-C21 alkyl, alkylene or alkynyl group, preferably a C11-C15 alkyl, alkylene or alkynyl group, particularly a C11-C13 alkyl, alkylene or alkynyl group, most preferably a C13 alkyl group, R2=independently, a straight or branched C1-C8 alkyl, alkylene or alkynyl group, preferably a C1-C6 alkyl, alkylene or alkynyl group, in particular a C2-C4 alkyl, alkylene or alkynyl group, most preferably a C3 alkyl group, a -[CH2-(CH2)m-O]nH group with n=1 to 10, preferably n=1 to 5, m=1 to 5, preferably m=1 to 3, a -CH2-[CH-(OH)]p[CH2-(R3)]- group, where R3=independent H or OH, p=1 to 7, preferably p=1 to 4, a pentose group or a hexose group, as therapeutically active agent,

alone or in combination with one or several further pharmaceutical agents as a combination preparation for the treatment of viral skin diseases and/or tumor diseases, in particular caused by human papilloma virus (HPV) and/or herpes viruses and a topically acting medicament formulation and the use thereof.

Priority: DE20011056794 Applic. Date: 2001-11-19; WO2002EP12919 Applic. Date: 2002-11-18; US20010331705P Applic. Date: 2001-11-19

Inventor: CHANG YUNIK [US]; LATHROP ROBERT [US]; BOEHM ERWIN [DE]; GANDER-MEISTERERNST IRENE [DE]; GREGER REGINA [DE]; HOLLDACK JOHANNA [DK]; MOEBIUS ULRICH [DE]

Title: N-acetyl aldosamines and related N-acetyl compounds, and their topical use

Applicant/Assignee:

Application No.: 11/590897   Filing Date: 01/Nov/2006

Abstract:

Compositions comprising N-acetyl-aldosamines, N-acetylamino acids, and related N-acetyl compounds are useful to alleviate or improve various cosmetic conditions and dermatological disorders, including changes or damage to skin, nail and hair associated with intrinsic aging and/or extrinsic aging, as well as changes or damage caused by extrinsic factors. N-acetyl-aldosamines, N-acetylamino acids, and related N-acetyl composition may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

Priority: US2000-560901 Applic. Date: 2000-04-28; US1999-227213 Applic. Date: 1999-01-08

Inventor: YU RUEY J [US]; VAN SCOTT EUGENE J [US]

Title: Crosslinked, water-soluble or water-dispersible polyurethanes

Applicant/Assignee: BASF SE

Application No.: 11/165555   Filing Date: 24/Jun/2005

Abstract:

The present invention relates to crosslinked, water-soluble or water-dispersible polyurethanes of A) at least one water-soluble or water-dispersible polyurethane prepolymer having terminal isocyanate groups of a) at least one compound having a molecular weight in the range from 56 to 300 which contains two active hydrogen atoms per molecule, b) at least one polymer containing two active hydrogen atoms per molecule, c) at least one compound which contains two active hydrogen atoms and at least one ionogenic or ionic group per molecule, d) at least one diisocyanate, B) at least one polymer containing groups which are reactive toward isocyanate groups, chosen from hydroxyl, and primary and secondary amino and/or carboxyl groups, or the salts thereof.

Priority: DE19981021732 Applic. Date: 1998-05-14; US1999-303426 Applic. Date: 1999-05-03