- Methods of delivering materials into the skin, and compositions used therein

Methods of using absorption enhancer as a component of skin care compositions for moisturizing and protecting the skin. Antimicrobial skin care compositions for cleansing and moisturizing the skin, comprising an absorption enhancer, an antimicrobial function enhancer unbound lipid removals, humectants, emollients and extracts of botanical herbs. Methods for preparing skin care compositions comprising an absorption enhancer/micro-carrier.

- Needle-less parenteral introduction device

A needle-less device for the parenteral administration of a medicament is disclosed. The medicament has the shape of one end of a toothpick. It is placed in the bore of a barrel with the barrel having the shape of a nose cone at one end. A plunger is inserted into the other end of the bore. The plunger forces the medicament through the skin and into subcutaneous layer of the patient without the need for the penetration of the skin by a needle.

- Medicated skin patch and method for its use

A medicated skin patch for delivering a topical anesthetic to an irritated region of skin includes a bibulous pad for contacting and covering the irritated region. A topical anesthetic is imbibed in the bibulous pad. A sheet of thin material covers the pad and projects beyond the pad to form an attachment region. At least a portion of the attachment region has an adhesive coating for affixing the sheet to the skin so that the pad is held in contact with the irritated region.

- Gibberellins (including gibberellins A.sub.3 and A.sub.7) used in ulcer or wound healing

Compounds of formula (1), (Gibberellins), and their pharmaceutically acceptable derivatives to promote ulcer-healing, healing of surgical wounds or open fractures and treatment of bronchitis or thrombophlebitis in animals including humans or cultivation of skin cell lines in vitro ##STR1## wherein A is COOR, where R is hydrogen, unsubstituted or substituted C.sub.1-20 alkyl, allyl, aryl, arylalkyl, amidine, NR.sup.4 R.sup.5 or an unsaturated or saturated ring containing one or more hetero-atoms selected from the group consisting of nitrogen, oxygen and sulfur; R.sup.4 and R.sup.5 may or may not be the same, are hydrogen, or C.sub.1-20 alkyl, allyl, aryl, arylalkyl or an unsaturated or saturated ring containing one or more hetero-atoms selected from the group consisting of nitrogen and sulfur; B is hydrogen, hydroxyl, mercaptan, or halogen, or A and B together form a --CO--O-- linkage; R.sup.1 is hydrogen, hydroxyl, mercaptan, halogen, amino, azido, NR.sup.4 R.sup.5, unsubstituted or substituted C.sub.1-20 alkyl, allyl, aryl, arylalkyl, and R.sup.2 is methylene, or a divalent hetero-atom.

- Disposable thermal neck wrap

The present invention relates to disposable thermal neck wraps having one or more thermal packs comprising a unified structure having at least one continuous layer of semirigid material, which has different stiffness characteristics over a range of temperatures, and a plurality of heat cells, wherein the heat energy is applied to specific areas of the upper back, neck and shoulders. More particularly, the present invention relates to disposable thermal neck wraps having good conformity to user's upper back, neck, and shoulders which provides consistent, convenient, and comfortable heat application.

- Composition for the treatment of the nails, containing a sulphur-bearing aminoacid

Composition for the treatment of the nails, containing a sulphur-bearing aminoacid or derivative thereof. This composition is prepared by introducing a sulphur-bearing aminoacid together with sodium tetraborate into an aqueous or water-alcohol medium. The combination of these two ingredients gives a composition with which embrittled or damaged nails can be treated and at the same time cuticles can be eliminated.

- Deodorant compositions containing cyclodextrin odor controlling agents

Disclosed are aqueous and anhydrous deodorant compositions which comprise from about 0.1% to about 89.9% by weight of a cyclodextrin odor controlling agent, from about 0.1% to about 30% by weight of a solid non-polymeric gellant and from about 10% to about 90% by weight of an aqueous or anhydrous liquid carrier. Also disclosed are methods of using and making the compositions. The disclosed compositions are especially effective at preventing or eliminating malodors resulting from perspiration.

- Cosmetic, dermopharmaceutical or veterinary compositions for disinfecting human or animal skin

The use of alkane-1,2-diols for inactivating skin microorganisms by topical application includes 1,2-Octanediol used against the germs that cause acne and dandruff, as well as those that cause mastitis in dairy animals, and its activity strengthened by a synergistic interaction with gels such as glycerol poly(meth)acrylate.

- Aqueous composition comprising active ingredients for the de-pigmentation of the skin

The present invention discloses aqueous compositions comprising liposomes of phospholipids, and at least one competitive inhibitor of an enzyme for the synthesis of melanin, in combination with at least one non-competitive inhibitor of an enzyme for the synthesis of melanin. The invention also includes the use of the compositions of this invention for the de-pigmentation of skin.

- Composition based on lipid vesicles and a cross-linked poly(2-acrylamido-2-methylpropane-sulphonic acid) which is at least 90% neutralized

A cosmetic and/or dermatological composition comprising an aqueous dispersion of lipid vesicles containing at least one cross-linked poly(2-acrylamido-2-methylpropanesulphonic acid) polymer which is at least 90% neutralized, comprising, distributed in a random manner: a) from 90 to 99.9% by weight of units of formula (1): ##STR1## in which X.sup.+ denotes at least one cation wherein no more than 10 mol % of the cations X.sup.+ are protons H.sup.+ ; b) from 0.01 to 10% by weight of cross-linking units obtained from at least one monomer having at least two olefinic double bonds; wherein the percentages by weight are relative to the total weight of the polymer.

- Desquamation/epidermal renewal of the skin and/or combating skin aging

The hydroxystilbenes are well suited for promoting desquamation and/or stimulating epidermal renewal and/or combating intrinsic/extrinsic aging of the skin of a human subject in need of such treatment, by topically applying thereto, for such period of time as required to elicit the desired response, a therapeutically effective amount of at least one of said hydroxystilbenes.

- (Zinc, cadmium, magnesium) aluminate-gallate-containing organic-binder paint and film articles

An article is a liquid or solid mixture of a plurality of particles and a binder. The article may be a paint or a freestanding film. The particles have a composition A[xAl(1-x)Ga].sub.2 O.sub.4+.gamma. (.delta.In), wherein A is zinc, magnesium, and/or cadmium, the value of x is from 0 to 1, the value of .delta. is from 0 to about 0.2, and the value of .gamma. is less than about 0.2. In the liquid paint mixture, a paint vehicle is also typically present to impart the desired fluidity to the mixture. The solid paint or film made using this material is white, has very low solar absorptance, and may be made electrically conductive by doping the particles with indium or other appropriate dopant.

- Method of treating a skin disease with a corticosteroid-containing pharmaceutical composition

Methods of treating various skin diseases, and in particular, scalp psoriasis, utilizing a foamable pharmaceutical composition comprising a corticosteroid active substance, a quick-break foaming agent, a propellant and a buffering agent are disclosed. The quick-break foaming agent typically comprises an aliphatic alcohol, water, a fatty alcohol and a surface active agent.

- Stable oil-in-water emulsion, process for its manufacture and its use in the cosmetic and dermatological fields

A fine and stable emulsion of an oily phase in an aqueous phase containing ionic polymer particles, the oil globules of the emulsion having a mean size of at most 500 nm, a process for the stabilization of fluid emulsions, a process for the preparation of these emulsions and their use in the cosmetic and dermatological fields and more particularly as composition for anti-sun protection.

- Fragrance delivery systems for personal care articles

The present invention relates to personal care and personal hygiene articles containing a fragrance delivery system which comprises one or more pro-accords, preferably .beta.-ketoester pro-accords, which are capable of releasing mixtures of fragrance raw materials. The pro-accords which comprise the fragrance delivery systems are useful in delivering sustained fragrances to personal care items inter alia deodorants, anti-perspirants, suntan lotions, hair sprays, mousses, shaving creams, body lotions and creams, depilitories, facial masks, athletic rubs and creams.

- Antiproliferative, antiinfective, antiinflammatory, autologous immunization agent and method

An antiproliferative, antiinflammatory, antiinfective, immunization agent of a metal ion chelating agent such as picolinic acid or derivatives thereof, and methods of using the same. The agents chelate metals in metal containing protein complexes required for growth, replication or inflammatory response. The preparations can be administered systemically or for topical use. The preparations have antineoplastic, antiviral, antiinflammatory and antiproliferative effects and are used in the treatment of warts, psoriasis, acne, skin cancers, sunburn and other proliferative diseases and in the prevention of sexually transmitted diseases such as genital warts, herpes and AIDS. The agents also can be used to induce autologous immunological response.

- Aqueous dispersion composition of lipid vesicles based on carbamates with a cholesteryl chain

The invention relates to a composition, in particular a cosmetic or dermatological composition, having an aqueous dispersion of vesicles with a lipid membrane, characterized in that the lipid membrane contains at least one carbamate of following formula (I): ##STR1## wherein R.sub.1 and R.sub.2 are defined in the specification.

- Disposable dosimeter for sun radiation

A disposable dosimeter for sun radiation comprising a matrix with at least one active chemical compound distributed therein, capable of changing its original color to a new color due to a chemical reaction induced by exposure to UV radiation, said matrix made of a material having transparency sufficient for visual detection the change of the original compound's color to the new color, said matrix containing at least one absorbing compound capable of absorbing the UV radiation, said active chemical compound being capable of changing its color after exposure to UV radiation with an efficacy corresponding to at least 1 MED, said UV radiation being accumulated during at least 15 minutes of exposure and said active chemical compound having a resistance to change the new color neither during exposure to temperatures up to 50.degree. C., nor during exposure to visible light.

- Resorcinol derivatives

The present invention relates to the use of certain resorcinol derivatives as skin lightening agents.

- Cosmetic composition in the form of a soft paste

The present invention relates to a cosmetic or dermopharmaceutical composition in the form of a soft paste, which can be used for making up or treating the skin or lips, comprising, in a fatty phase, from 12% to 60% by weight, relative to the total weight of the composition, of at least one wax having a melting point above 55.degree. C., the said composition having a dynamic viscosity at 25.degree. C. of between 3 and 30 pascal-seconds. The present invention also relates to the process for preparing this composition.

- Talcum powder composition

This invention relates to a synergistic combination of porous material such as metal silicates, silica, metal hydroxycarbonates, metal hydroxides, al carbonates, metal aluminates with talc for use in talcum powders, deodorants, perfumery and other like cosmetic formulations and method for the manufacture of the same.

- Cleansing products with improved moisturization

The present invention relates to a substantially dry, disposable, personal cleansing product useful for both cleansing and conditioning the skin or hair. These products are used by the consumer by wetting the dry product with water. The product comprises of a water insoluble substrate, a lathering surfactant, and a conditioner component. The invention also encompasses methods for cleansing and conditioning the skin or hair using these products and to methods for manufacturing these products.

- Manufacturing method of semiconductor

A microwave is applied, in an atmosphere that prohibits formation of plasma, to an amorphous silicon film that has been formed on a glass substrate by a vapor phase method. Since the microwave is absorbed selectively by a surface layer of the amorphous silicon film due to the skin effect, the amorphous silicon film can be heated selectively and thereby modified into a crystalline silicon film without heating the glass substrate.

- Multi-functional biomedical electrodes

A multi-functional, differing electrochemical potential biomedical electrode is disclosed. Several embodiments are described based on the difference in composition of multiple conductors, the difference in composition of fields of ionically conductive media, or both on a single insulative backing of a tab/pad style electrode. A galvanic circuit can be created from electrodes of the present invention, permitting self-restoration of defibrillation recovery of monitoring electrodes and the powering of iontophoretic delivery of pharmaceuticals, among other uses.

- O/W emulsion with a high electrolyte content and its use in dermocosmetics, in particular for treating irritation and/or sensitive skin phenomena

A composition in the form of an O/W emulsion comprising at least 2% by weight, relative to the total weight of the composition, of at least one water-soluble metal salt, and from 2-4.5% by weight, relative to the total weight of the composition, of a suitable emulsifying system, excluding compositions comprising 1% by weight of a gelling agent consisting of a combination of a polyacrylamide, C.sub.13 -C.sub.14 isoparaffin and laureth-7 (CTFA).

- Dermatological/pharmaceutical compositions comprising volatile oils/phenylated silicone oils

Transfer/migration-resistant, topically applicable dermatological/pharmaceutical compositions well suited for preventatively and/or curatively therapeutically treating human skin or mucous membranes, comprise at least one volatile oil, at least one phenylated silicone oil and at least one dermatologically and/or pharmaceutically bioaffecting active agent, for example at least one anviral, antibacterial, antifungal, anti-inflammatory, neuromediator modulator, etc.

- 5,5-disubstituted-3,4-dihydroxy-2(5H)-furanones and methods of use therefor

The present invention relates to synthetic methods for the production of both optically active and racemic 5,5-disubstituted-3,4-dihydroxy-2(5H)-furanones; 5-[(4-aryl)-3-butynyl]-3,4-dihydroxy-2(5H)-furanones; 5-(2-arylthio)ethyl-3,4-dihydroxy-2(5H)-furanones; and 5-(2-aryloxy)ethyl-3,4-dihydroxy-2(5H)-furanones. This invention further relates to the use of the above mentioned compounds as anti-inflammatory agents through their action as mixed inhibitors of lipid peroxidation, 5-lipoxygenase, cyclooxygenase-1 and cyclooxygenase-2. The invention further relates to the use of such compounds in the treatment of chronic inflammatory disorders such as asthma, rheumatoid arthritis, inflammatory bowel disease, atherosclerosis, acute respiratory distress syndrome, and central nervous system disorders such as Alzheimer's and Parkinson's disease wherein reactive oxygen species and inflammatory mediators are contributing deleterious factors.

- Tocopherol esters and their cosmetic and pharmaceutical uses

The invention relates to an ester. The ester is characterized in that it presents the following chemical formula (I): ##STR1## in which: R.sub.1, R.sub.2 and R.sub.3 independently represent an atom of hydrogen, a methyl radical, A represents the following groups: ##STR2## R.sub.4 and R.sub.5 are identical or different and each represents a chain of the form: in which: B is the following group: ##STR3## C is the following group: ##STR4## and in which the indices m, n, p, and q are respective integers lying in the range 0 to 4, it being understood that the sum m+n+p+q is limited to integers in the range 0 to 4. The ester can be used for preparing cosmetic or pharmaceutical, in particular dermatological, compositions having activity against radicals, against inflammation, favoring differentiation of keratinocytes, improving skin moisturizing, improving skin grain fineness, and having anti-aging or depigmenting activity.

- Preparation of cell seeded ceramic compositions

The present invention provides a synthetic, poorly-crystalline apatitic (PCA) calcium phosphate material seeded with cells. Preferably, the cells are tissue-forming or tissue-degrading cells. The compositions provided by the present invention are useful for a variety of applications, including in vivo and in vitro tissue growth (preferably bone or cartilage), osseous augmentation, and methods of diagnosing disease states by assaying tissue-forming potential of cells isolated from a host. The invention also provides in vitro cell culture systems and cell encapsulation matrices.

- Structured water in cosmetic compositions

The invention relates to composition having enhanced biological activity, the compositions comprising at least one structured water. In particular, the compositions contain a combination of I and S waters and a biologically active agent, in which the activity of the agent is increased relative to its activity in a non-structured water composition.

- Composition useful for providing one-step surgical preparation and drape

This invention relates to an improved polyvinylidene fluoride-based composition useful for forming a flexible, tack-free, nonflammable, substantially fluid resistant barrier film with substantially improved durability and skin-adhesion properties. The composition providing a long-lasting protective barrier film capable of disinfecting the skin surface of normally present microorganisms upon initial application, and said film imparting continuous and prolonged antimicrobial properties to the skin surface through sustained release of an encapsulated antimicrobial agent. The barrier film is further capable of remaining substantially adherent to the skin surface after prolonged exposure to biological fluids. A kit and methods of use for the composition are disclosed.

- Methods and compositions for topical treatment of ectoparasites

Methods and compositions for the topical treatment of ectoparasites on animal skin utilizing a water-soluble or water-dispersible, substantially air-impermeable liquid composition.

- Transdermal therapeutic system, its use and production process

A therapeutic system for supplying active substances to the skin consists of a backing layer remote from the skin, with at least one active substance depot. The depot may consist of a fluid active substance or a fluid composition comprising an active substance delivery control matrix. There is also included an adhesive fixing device for fixing the therapeutic system on the skin. The therapeutic system is characterized in that the active substance depots (14) consist of at least one adjuvant having a supporting and distributing function by being provided with a planar textile material completely surrounded by matrix (12).

- Photoprotective/cosmetic compositions comprising benzotriazole-substituted silicon sunscreens and cinnamic/salicylic acid solubilizing agents therefor

Topically applicable cosmetic/dermatological sunscreen compositions well suited for the UV-photoprotection of human skin and/or hair against the damaging effects of UV-A and UV-B irradiation, particularly solar radiation, comprise (i) a UV-photoprotecting effective amount of at least one solubilized organolipophilic silicon compound, whether solid silane or organopolysiloxane, bearing a benzotriazole function substituent and (ii) an amount of at least one cinnamic acid sunscreen compound and/or at least one salicylic acid sunscreen compound effective to (substantially) dissolve said at least one organolipophilic silicon compound.

- Cosmetic composition in the form of a transparent foaming gel

Cosmetic compositions in the form of a transparent foaming gel comprising: (i) at least one alkyl ether carboxylic acid with a fatty chain, (ii) at least one diol with a fatty chain, and (iii) water.

- Cosmetic compositions

A cosmetic composition in the form of water-in-oil emulsion comprising: (a) a continuous oil phase, (b) a discontinuous phase, and (c) an amino acid salt of salicylic acid or an amino acid salt of a salicylic acid derivative. The composition of the invention provide regulation of the oily and/or shiny appearance of the skin.

- Monitoring of physiological analytes

Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.

- Disappearing color sunscreen compositions

Sunscreens are colored with oil-soluble dyes approved for use in skin care products (such as sunscreens, lotions, etc.). The color imparted by the dyes substantially disappears shortly after the sunscreen emulsion is applied to skin. This colored sunscreen emulsion includes a oil-soluble phase, at least one sunscreen active agent, water, and an emulsifier. The oil-soluble phase comprises from about 0.0005 to about 0.5 percent by weight of the complete emulsion of at least one oil-soluble dye. The dye imparts a color other than white to the sunscreen emulsion. The sunscreen active ingredient is provided in an amount effective to protect against the actinic radiation of the sun. Sufficient water is provided to form the colored emulsion. The emulsion additionally contains at least one emulsifier in an amount effective to provide an at least substantially stable emulsion. Other optional ingredients may also be compounded into the sunscreen formulations.

- Shaving compositions useful in altering the growth of male beard hair

The character of male beard hair growth is altered by employing a conventional shave enhancing composition containing a topically active chemical agent capable of acting upon the sites influencing beard hair growth.

- Photobluing/whitening-resistant cosmetic/dermatological compositions comprising TiO.sub.2 pigments and deformable hollow particulates

Topically applicable cosmetic/sunscreen/dermatological compositions, well suited for improved photoprotection of human skin and/or hair against the damaging effects of UV-A and UV-B irradiation and/or for the therapeutic treatment of a disease state of the skin or mucosae, essentially in the absence of photobluing/whitening, comprise at least one titanium dioxide (nano)pigment and an effective photobluing/whitening-reducing amount of deformable hollow particulates (microspheres) having a particle size ranging from 1 .mu.m to 250 .mu.m and which comprise an expanded copolymer of vinylidene chloride, acrylonitrile and a (meth)acrylate.

- Composition for cosmetic, pharmaceutical or dietetic use based on an amino sugar and/or a polyhydroxylic acid

A composition for cosmetic, pharmaceutical or dietetic use and including as the active ingredient, at least one of the substances which include acetylglucosamine and glucuronic acid in combination with the active ingredients which belong to the chemical class of the carboxylic acids, .alpha.-hydroxy acids, vitamins, amino acids, and bioflavonoids, and formulated with particular synergists, additives, and excipients for external use or for internal use.

- Synergistic antimicrobial skin washing compositions

A synergistic composition and a synergistic system for use in treating the skin and hair of people and animals comprises separate treatment compositions (solution, dispersions, emulsions, suspensions or other liquid or liquefiable materials). One treatment with a first composition that may comprise at least 0.1% by weight of antimicrobially active aliphatic phenol derivative and treatment with another composition being selected from the group consisting of: a) a solution comprising an antimicrobially active cationic species; b) a comprising antimicrobially active aliphatic phenol derivative, preferably in a different weight percentage of antimicrobially active aliphatic phenol derivative than said one composition, comprising greater than 0.3% antimicrobially active aliphatic phenol derivative; c) a solution comprising an alcohol provides a synergistic antimicrobial action. These compositions do not have to be applied in any particular order, and more than two compositions may be combined in separate or sequential applications. The single compositions of the present invention comprise, for example, a single composition comprising at least 0.1% by weight Triclosan and at least one synergistic additive selected from the group consisting of chlorhexidene gluconate, solutions with greater than 0.3% Triclosan and an alcohol. These compositions, both as single compositions or as separate compositions have been found to provide synergistic antimicrobial effects. It is surprising that even when the separate compositions are applied with significant periods of time between application of the individual compositions (e.g., 2, 3, 5 or even 8 hours between applications) a synergistic effect may be provided. This is believed to be at least in part because some of the materials may persist on the skin and later would be combined with the application of the other synergistic composition. Because of the unique ability to provide synergy in separate compositions, with gaps in time between application of the separate materials, a system of washing, cleansing, lubricating, and moisturizing compositions may be provided within a health care complex. In this manner, as an individual applies the various compositions over the course of the day, due to varying activity, not only will an individual application of antimicrobial agent occur, but a synergistic effect can be initiated.

- Stable W/O/W emulsion and its use as cosmetic and/or dermatological composition

A composition in the form of a water/oil/water triple emulsion comprising an outer aqueous phase and an oily phase constituting, with an inner aqueous phase, a W/O primary emulsion, the outer aqueous phase comprising, in combination, an emulsifying copolymer of carboxylic acid with a fatty chain, and a crosslinked poly(acrylamidomethylpropane-sulfonic acid). The emulsion remains stable, even in the presence of an acidic active agent, and is particularly appropriate as vehicle for water-sensitive and/or oxygen-sensitive active agents, in particular in a cosmetic or dermatological composition. The active agent can be, in particular, a vitamin, such as ascorbic acid or retinol, an enzyme and an .alpha.- or .beta.-hydroxy acid. The emulsion obtained can constitute, in particular, a composition for cleaning and/or treating and/or protecting the skin and/or mucous membranes and/or keratinous fibers.

- Composition for enhancing lipid production, barrier function, hydrogen peroxide neutralization, and moisturization of the skin

Increased production of skin lipids, increased barrier function, hydrogen peroxide neutralization, prevention of loss of the natural moisturizing factor from the stratum corneum and moisturization of the skin is provided by a topically applicable composition which includes one or more components selected from the group consisting of branched chain amino acids, derivatives of branched chain amino acids and mixtures thereof, which one or more components are capable of being catabolized in epidermal cells to form lipid precursors for epidermal lipid synthesis. The composition can also include one or more enzyme activators which increase the rate of catabolism of the one or more components.

- Compositions of oak bark extract related synthetic compositions and method of using same

Higher concentrations of oak bark ash extract, i.e., greater than 20% by weight, are useful for the treatment of skin cancers. Lower concentrations of oak bark extract possess additional therapeutic properties not heretofore recognized. For example, preparations containing 40-80% oak bark extract are useful in the treatment of acute cancerous skin ulcers. In addition, synthetic mixtures containing potassium ions, zinc ions, calcium ions provide many of the same advantageous properties of oak bark extract. The inclusion of rubidium ions and sulfur is also advantageous for some applications.

- Conjugate of an active agent, a polyether and possibly a native protein regarded as acceptable by the body

This invention relates to the use of a conjugate comprising an active substance and a native protein which is not recognized as foreign protein for the production of a pharmaceutical preparation for treating and/or diagnosing inflammatory, infectious and/or skin diseases.

- Stable gelled composition containing lipophilic active agents sensitive to oxygen and/or water

A stable gelled composition, containing at least one lipophilic active agent sensitive to oxygen or to water or to both, and a solvent which contains, as gelling agent, at least one polysaccharide alkyl ether formed of units containing at least two different glycoside rings, each unit containing at least one hydroxyl group substituted with a saturated hydrocarbon alkyl group.

- Method for non-invasive blood analyte measurement with improved optical interface

A method for non-invasively measuring the concentration of an analyte, particularly blood analyte in blood. The method utilizes spectrographic techniques in conjunction with an improved optical interface between a sensor probe and a skin surface or tissue surface of the body containing the blood to be analyzed. An index-matching medium is disclosed to improve the interface between the sensor probe and skin surface during spectrographic analysis. In a preferred embodiment, the blood analyte concentration in blood is quantified utilizing a partial squares analysis relative to a model incorporating analysis of plural known blood samples.

- Low pH sunscreen compositions

The present invention relates to low pH topical sunscreen compositions which utilize unneutralized, 2-phenylbenzimidazole-5-sulfonic acid as the sunscreen active. These compositions exhibit good sunscreening efficacy and are highly substantive to the skin.

- Anti-cellulite pantyhose

A garment for treating the skin, a method of making the garment and a method of using the garment to treat the skin, made of garment material, in particular hose material to be worn tightly against the skin, which has a multiplicity of durable chemical bonding sites. The durable sites which are preferably of the type to make covalent bonds, are bound to binding molecules which form chemical hooks for the garment material. Each of the chemical hooks has one or more semi-durable chemical bonding sites of the type which can chemically bond an active ingredient molecule to the binding agent but which is broken in the presence of skin conditions which are normal such as normal skin pH, normal skin moisture and normal skin heat generated both by body heat and the heat of friction of the garment rubbing against the skin. Active ingredient molecules such as molecules of theophylline or theophylline complexes are bound to the binding agent and are released to the skin when the garment is worn.

- Cleansing and conditioning article for skin or hair

The present invention relates to a substantially dry, disposable, personal cleansing article useful for both cleansing the skin or hair, and more particularly to a disposable, cleansing article having a substrate which preferably comprises of multiple layers. These articles are used by the consumer by wetting the dry article with water. The article comprises a water insoluble substrate having at least a first portion that is wet extensible and at least a second portion that is less wet extensible than said first portion and a lathering surfactant. Preferably, the articles of the present invention further comprise a conditioning component.

- Transdermal estradiol/progestogen agent patch and its production

The invention concerns a transdermal patch for the release through the skin of estradiol and a progestogen agent and a process for its production.

- Use of carboxylic acids having a sulphur function for promoting skin exfoliation or stimulating epidermal regeneration

The use of carboxylic acids having a thioether function, a sulphoxide function or a sulphone function in or for making a cosmetic or dematological composition for promoting skin exfoliation and/or stimulating epidermal regeneration, is disclosed. The use of said composition for controlling intrinsic and extrinsic skin ageing, and a non-therapeutic skin treatment method useful for skin exfoliation, are also disclosed.

- Conditioning and detergent compositions and use

The present invention relates to a conditioning and detergent cosmetic composition for keratinous substances comprising, in an aqueous medium: (A) at least one non-volatile vegetable oil, (B) at least one anionic sulphate surface-active agent, (C) at least one non-ionic alkyl glycoside surface-active agent, the (B)/(C) ratio by weight being less than or equal to 2:1. Use in simultaneously caring for and washing keratinous substances, in particular the hair.

- Preparation with an acrylic-based, adhesive copolymeric matrix for the transdermal delivery of estradiol

The invention is represented by a transdermal medicated patch for the extended release of 17.beta.-estradiol to the skin. The transdermal patch is formed by an outer covering, a matrix containing from 1% to 5% (w/w) 17.beta.-estradiol, and a protective liner which is removed before use. The matrix is formed of pressure-sensitive adhesive acrylic copolymers, in which the active ingredient is dissolved or dispersed. The acrylic copolymers are obtained by radical copolymerization of 2-ethylhexyl acrylate, methyl acrylate, acrylic acid, vinyl acetate, hydroxyethyl acrylate or a mixture thereof. Optionally quantities of less than 0.5% (w/w) of other substances may be added.

- Use of anionic gemini tensides in formulations for washing, cleaning and body care agents

The present invention relates to the use of anionic gemini tensides of the formula (I) ##STR1## in which R.sup.1 and R.sup.3 are, mutually independently, a hydrocarbon radical with 1 to 22 carbon atoms, R.sup.2 is a spacer containing 0 to 100 alkoxy groups, and X and Y, mutually independently, are functional groups and the degree of substitution Z=1 to 10, in washing, cleaning and body care agents in which the proportion of said tensides amounts to at least 0.1%.

- Local administration of type III phosphodiesterase inhibitors for the treatment of erectile dysfunction

A method is provided for treating erectile dysfunction, e.g., vasculogenic erectile dysfunction such as vasculogenic impotence. The method involves the administration of a Type III phosphodiesterase inhibitor or a pharmaceutically acceptable salt, ester, amide or derivative thereof, wherein administration is transurethral, topical or transdermal. A preferred mode of administration is transurethral. Pharmaceutical formulations and kits are provided as well.

- Use of a microdispersion of wax in a cosmetic or dermatological composition

Wrinkles and fine lines of the skin are treated and/or cutaneous and/or subcutaneous slackening of the skin is combated and/or the radiance of the skin is revived by topically treating the skin with a microdispersion of wax in a topical composition.

- N-aryl-2-hydroxyalkylamido compositions for inducing/stimulating hair growth and/or retarding hair loss and/or for treating hyperseborrhea and/or acne

Novel N-aryl-2-hydroxyalkylamido compounds having the formula (I): ##STR1## are well suited for inducing/stimulating hair growth and/or retarding hair loss and/or for therapeutically treating hyperseborrhea and/or acne.

- Photoprotective/cosmetic compositions comprising camphorsulfonic acid and bisresorcinyltriazine sunscreens

Topically applicable sunscreen/cosmetic compositions well suited for the synergistically enhanced photoprotection of human skin and/or hair against the damaging effects of UV-irradiation, particularly solar radiation, comprise synergistically UV-photoprotecting effective amounts of each of (i) benzene-1,4-di(3-methylidene-10-camphorsulfonic acid, or partially or completely neutralized form thereof, and (ii) at least one bisresorcinyltriazine compound, formulated into a topically applicable, cosmetically acceptable vehicle, diluent or carrier therefor.

- Use of oxamate derivatives as depigmenting agents

The invention relates to the use of oxamate derivatives in a composition, as agents for depigmenting and/or bleaching human skin, head hair and/or other hairs. The invention also relates to a process for depigmenting and/or bleaching the skin, head hair and/or other hairs, which includes applying a composition comprising oxamate derivatives to human skin, head hair and/or other hairs.

- Cosmetic or pharmaceutical compositions

A cosmetic or pharmaceutical composition containing a dermatologically effective amount of at least one liposome containing a compound of the formula ##STR1##

- Microstructured compositions

The present invention provides a microstructured cosmetic composition comprising: A) a cosmetically acceptable oil phase which is dispersed in; B) an aqueous phase comprising 0.05 to 3.0, preferably 0.2 to 1.0% by weight, based on the weight of the total composition, of a .beta.-1,3-glucan having a mean molecular weight within the range of from 1.times.10.sup.6 to 12.times.10.sup.6, preferably from 2.times.10.sup.6 to 10.times.10.sup.6 ; the oil phase A) in the microstructured cosmetic composition having a mean particle size within the range of from 0.05 to 1000 microns.

- Patch for beautification

The present invention provides a patch for beautification comprising a support and an adhesive mass, wherein the adhesive mass contains active components that have a skin-refreshing effect, a skin-clearing effect and/or a slenderizing effect. The active component of the patch for beautification of the present invention having at least one of a skin-refreshing effect, a skin-clearing effect and a slenderizing effect can effectively and sustainedly act on a desired site of the body.

- Light-duty liquid or gel dishwashing detergent compositions having beneficial skin conditioning, skin feel and rinsability aesthetics

Liquid and gel dishwashing detergent compositions which exhibit good cleaning performance and desirable skin feel and rinsability aesthetics are disclosed. Such compositions comprise detergent surfactants, a nonionic surfactant- and hydrotrope-containing skin feel/rinsability enhancing system and small amounts of selected skin conditioning protease enzymes. Such compositions additionally will preferably contain suds boosters and divalent metal cations.

- Foaming oil-in-water emulsion based on nonionic surfactants, a fatty phase and a crosslinked cationic or anionic polymer, and its use in topical applications

A foaming oil-in-water emulsion in the form of a cream comprising, in an aqueous medium, at least: a) from 5 to 20% of an exclusively nonionic surfactant system comprising at least one foaming nonionic surfactant; b) from 10 to 50% of an oily phase containing at least one water-insoluble oil whose solubility parameters dD, dP and dH according to Hansen's solubility space satisfy the conditions: c) and, as a gelling agent, at least one crosslinked homopolymer or copolymer formed from at least one cationic or anionic monomer containing ethylenic unsaturation and from a crosslinking agent containing polyethylenic unsaturation. This composition is useful in cosmetics, dermatology and hygiene as a base for cleansing products for the skin, the hair, the mucous membranes and the scalp.

- Transdermal preparation containing a loratidine metabolite with antihistaminic activity

A transdermal patch contains an active loratidine metabolite contained with a polyacrylate polymer matrix. The transdermal patch provides pharmaceutically useful transdermal flux rates over time.

- Transdermal therapeutic system with small application-area thickness and great flexibility, and production process

A transdermal therapeutic system for the release of active substances to a substrate is characterized by the structure of the system comprising a substrate (1) provided with a separating layer (2), a film layer (3) comprising the active substance, and a protective layer (4) provided with a nonstick finish, the separating layer (2) consisting of a material whose bond to the film layer (3) may be abolished. By means of printing methods, such systems having small application thickness and high flexibility can be manufactured, it being possible to provide a substrate that has been rendered adhesive as an alternative to the substrate/separating layer-complex. A printing method limiting the active substance-containing region to the application site reduces disposal problems.

- Preparation for the application of agents in mini-droplets

The invention relates to a preparation for the application of agents in the form of minuscule droplets of fluid, in particular provided with membrane-like structures consisting of one or several layers of amphiphilic molecules, or an amphiphilic carrier substance, in particular for transporting the agent into and through natural barriers such as skin and similar materials. The preparation contains a concentration of edge active substances which amounts to up to 99 mol-% of the agent concentration which is required for the induction of droplet solubilization. Such preparations are suitable, for example, for the non-invasive applications of antidiabetics, in particular of insulin. The invention, moreover, relates to the methods for the preparation of such formulations.

- Use of sericin as antioxidants and tyrosinase inhibitors

This invention relates to a composition useful as an antioxidant or an inhibitor for tyrosinase activity which comprises as an active ingredient a sufficient amount of sericin to exert an antioxidizing ability or an inhibiting action on tyrosinase activity and this composition is applicable as an antioxidant or a tyrosinase activity inhibitor in the field of medicines, quasi-drugs, medicines for external use, cosmetics, foods, food additives or the like.

- Stable gelled composition with a high electrolyte content

A gel composition containing an at least one cosmetic and/or dermatological active agent, at least one electrolyte, cetylhydroxyethyl cellulose and water. The composition is useful for treating the skin, scalp, hair, mucous membranes and/or nails.

- Elastomeric silicone containing an active ingredient

Elastomeric silicones, especially elastomeric silicone polyethers, are prepared by combining and reacting (A) an .tbd.Si--H containing polysiloxane, (B) a mono-alkenyl polyether, (C) an active ingredient such as a vitamin, antimicrobial agent, sunburn prevention agent, astringent, or sex hormone, (D) an .alpha.,.omega.-unsaturated hydrocarbon, (E) a platinum catalyst, and (F) an oil. The reaction of components (A)-(F) is allowed to continue, forming a crosslinked three-dimensional gelled network of the elastomeric silicone polyether containing the active ingredient and the oil. The compositions are useful in personal and health care applications, personal hygiene, and household cleaning applications.

- .beta.-D-glucan topical composition

A topical composition for healing treatment of burns and wounds and scarring therefrom has as the active ingredient cereal-derived (1-3) (1-4) .beta.-D-glucan at about 0.5-15 w/w percent. The composition may be formulated in various forms with creams and gels being preferred for application to the skin.

- Alkaline-earth metal salt for the treatment of ocular or palpebral pruritus and dysesthesia

The invention relates to the use of an alkaline-earth metal salt in or for the preparation of a cosmetic or pharmaceutical composition, especially for topical application, for treating ocular or palpebral pruritus and/or ocular or palpebral dysesthesia. The cosmetic composition can be used for applying make-up to or removing make-up from sensitive eyes.

- Rejuvenating the skin using a combination of vitamin A and alphahydroxy acids

Methods of accelerating skin rejuvenation and methods of skin care treatment are disclosed using a combination of vitamin A and alphahydroxy acids, such as the combination of vitamin A propionate and glycolic acid. The combination can be prepared in an alcohol-based carrier having concentrations ranging from approximately 0.01% to 10% vitamin A propionate, preferably 0.1% to 4%, and 0.1% to 30% glycolic acid, preferably 2% to 10% glycolic acid. In addition to alcohol, the carrier may also include propylene glycol, preservatives, thickeners and non-ionic surfactants or may be a cream or ointment-based formulation. The formulation is applied topically to the skin at a frequency which will produce a fine desquamation. The formulation may also be used to accelerate the penetration of other therapeutic agents into the skin.

- Synergistically UV-photoprotecting triazine/silicone compositions

The invention relates to novel cosmetic and/or dermatological compositions, in particular for photoprotecting the skin and/or the hair, characterized in that they comprise, in a cosmetically acceptable support in particular of oil-in-water type, (i) as first screening agent, at least one specific 1,3,5-triazine derivative, and (ii) as second screening agent, a silicon derivative containing a benzotriazole function, the said first and second screening agents being present in the said compositions in an amount which is effective for producing synergistic activity with respect to the sun protection factors imparted. Application to protecting the skin and the hair against the effects of ultraviolet radiation.

- Low residue antiperspirant gel-solid stick compositions

Disclosed are anhydrous antiperspirant gel-solid stick compositions which comprise a particulate antiperspirant active; a solid non-polymeric gellant that is substantially free of dibenzylidene alditol, n-acyl amino acid derivatives, organic polymeric gellants, and inorganic thickening agents; and an anhydrous liquid carrier having an average solubility parameter of from about 3 to about 13 (cal/cm.sup.3).sup.0.5 wherein the composition has a visible residue index of from about 11 to about 30 L-value, a product hardness of from about 500 gram-force to about 5,000 gram-force, a ratio of an elastic to viscous moduli of from about 0.1 to about 100. The refractive indices of the particulate antiperspirant active, solid non-polymeric gellant, and anhydrous liquid carrier are not matched. The solid non-polymeric gellant is preferably a crystalline material having an average particle size of less than about 1 .mu.m, and/or has an elongated particle morphology having an aspect ratio of greater than about 2. These antiperspirant gel-solid stick compositions provide improved low residue performance, antiperspirant and aesthetics.

- Honey preparations

Methods and preparations for overcoming problems associated with the local application of honey are disclosed. The preparations include active ingredients of honey and a base including components selected from the group consisting of oils, gelling agents, emulsifiers and combinations thereof. Although honey is preferably used as is, the active ingredients of honey, including vitamins, sugars, enzymes, hormones, amino acids and minerals, may be extracted from honey or other natural products or synthesized. Potential applications for the present invention include topical treatments for therapeutic, cosmetic and nutritional purposes, including hair growth, hair loss prevention and wound healing.

- Self tanning compositions containing DHA and propolis extract

The present invention relates to self-tanning compositions comprising an effective amount of DHA in combination with an effective amount of propolis extract. The compositions provide self-tanning compositions which can produce a tan with enhanced coloration. The self-tan produced using the compositions of the present invention is more natural looking. In another embodiment of the present invention, the compositions comprise DHA combined with caffeic acid phenethyl ester.

- Quinoline-indole antimicrobial agents, uses and compositions related thereto

The present invention provides methods and pharmaceutical preparations that inhibit the growth of bacterial microorganisms. Additionally, the present invention provides methods and pharmaceutical preparations that kill bacterial microorganisms.

- Preparation process of biologically active silicon compounds in a concentrated form

A process for the preparation of biologically active silicon compounds by hydrolysis of a precursor which produces a compound which prevents the formation of polymers from the silicon hydrolyzed bonds.

- Gel deodorant compositions having reduced skin irritation

Disclosed are gel deodorant compositions comprising (a) from about 0.001% to about 50% by weight of a deodorant active, fragrance, or combination thereof; (b) from about 0.01% to about 20% by weight of a gellant; (c) from about 5% to about 90% by weight of a polymeric alcohol having at least one free hydroxyl group and also having from about 2 to about 80 alkoxylate radicals wherein the alkoxylate radical contains from about 2 to about 6 carbon atoms; (d) from about 5% to about 89% by weight of a nonpolymeric alcohol having at least two free hydroxyl groups, and also having from about 4 to about 20 carbon atoms, wherein the weight ratio of the polymeric to nonpolymeric alcohol is from about 18:1 to about 1:5; (e) from zero percent to about 10% by weight of glycerin; and (f) from about 0.01% to about 89% by weight of water. Also disclosed is a method of controlling malodor associated with perspiration by topical application of any deodorant composition containing a select combination of triclosan and triclocarban. All of these compositions remain clear or translucent over extended periods of time, and provide little or no skin irritation in addition to improved cosmetic benefits such as dry feel, ease of application, emolliency, fragrance longevity, and no powdery residue.

- Transdermal pressure sensitive adhesive drug delivery system

A transdermal drug delivery system is provided which includes an optionally crosslinked macromer-reinforced (meth)acrylic ester base copolymer pressure sensitive adhesive wherein the macromer includes repeat hydrophilic units.

- Solid deodorant composition

The invention relates to a solid deodorant composition, which is essentially anhydrous and comprises, as a solidifying agent, a mixture of waxes containing at least one synthetic polyethylene wax having a melting point of greater than 80.degree. C., and at least one wax of natural origin having a melting point of greater than 80.degree. C., as well as at least one deodorant active principle and a process for reducing the flow of sweat, and for masking, improving or reducing the unpleasant smell resulting from the decomposition of human sweat by bacteria using said composition.

- Vinyl amide polymer delivery system for hair and skin treating compositions

A cosmetically active oil-in-water (o/w) or water-in-oil (w/o) emulsion, for topical applications comprising (a) the reaction product of a non-aqueous, heterogeneous polymerization of a liquid reaction mixture containing between about 5 and about 70%, preferably 10-40%, by weight, of N-vinylamide monomer in an oil solvent, a free radical initiator, between about 0.1 and about 2.5% by weight of a crosslinking agent and optionally a surfactant, (b) water sufficient to form said emulsion, (c) a cosmetically active hair and/or skin treating chemical or chemical composition and optionally (d) a surfactant.

- Polar solvent-in-oil emulsions and multiple emulsions

One composition is a non-aqueous polar solvent-in-oil emulsion containing a non-aqueous polar solvent phase dispersed in a silicone oil continuous phase by an emulsifier. A second composition is a non-aqueous polar solvent-in-oil-in-water multiple emulsion of the type PS.sub.1 /O/W which contains a non-aqueous polar solvent phase PS.sub.1 dispersed in a silicone oil as a first continuous phase of a primary emulsion PS.sub.1 /O by an emulsifier. The primary emulsion PS.sub.1 /O is dispersed in a second continuous aqueous phase W to form multiple emulsion PS.sub.1 /O/W. A third composition is a non-aqueous polar solvent-in-oil-in-non-aqueous polar solvent multiple emulsion of the type PS.sub.1 /O/PS.sub.2 which contains a non-aqueous polar solvent phase PS.sub.1 dispersed in a silicone oil as a first continuous phase of a primary emulsion PS.sub.1 /O by an emulsifier. The primary emulsion PS.sub.1 /O is dispersed in a second continuous non-aqueous polar solvent phase PS.sub.2 to form multiple emulsion PS.sub.1 /O/PS.sub.2.

- Use of at least one sulphonic acid for stimulating renewal and/or epidermal repair and for combatting cutaneous aging and conditions

The use of specific sulphonic acids or hydrates thereof in or for the preparation of a cosmetic or dermatological composition for achieving various effects on the skin, such as promoting desquamation of the skin, stimulating epidermal renewal, combatting intrinsic and extrinsic cutaneous aging. A process for the non-therapeutic treatment of the skin intended to achieve such effects, such as to promote the desquamation of the skin.

- Non-migrating make-up or care composition containing an organopolysiloxane and a fatty phase

A non-migrating composition containing a solid, partially crosslinked, elastomeric organopolysiloxane and a fatty phase containing at least one non-volatile oil and at least one wax, particularly for the care or make up the lips and the face. This composition is gentle to apply, spreads easily, is non-sticky and does not dry the skin or the lips.

- Solid cosmetic composition and uses thereof

A solid composition free of fillers, comprising an aqueous phase, wherein said aqueous phase comprises a hydrocolloid combination of gellane gum and at least one other hydrocolloid, wherein said gellane gum is present in an amount of at least 2% by weight, relative to the total weight of the composition, and wherein said hydrocolloid combination is present in an amount of less than 20% of the total weight of the composition, formable as tubes, pencils or bars, and useful to care for and/or treat the skin, the scalp, the hair or mucous membranes, to make up the skin and/or keratin fibers such as the eyelashes and the hair, and to style and/or shape keratin fibers, and in particular the hair.

- Composition for topical application comprising an olefin copolymer of controlled crystallization and use of such a copolymer in the manufacture of compositions for topical application

A composition for application to keratinous substances, comprising: a liquid fatty phase and an effective amount of at least one copolymer which is soluble or dispersible in the liquid fatty phase which is selected from crystalline olefin copolymers having a degree of crystallinity of at most 50%.

- Method and device for predicting physiological values

The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.

- Method for treatment of dermatological disorders

A compound effect for the treatment of dermatological disorders comprises a mono- or diester of an .alpha.,.omega.-dicarboxylic acid, wherein the alcohol moiety of the said ester comprises a keratolytically active alcohol. The compound may have the formula, ##STR1## where n is in the range of 6 to 12; m is in the range of 0 to 8; R' is selected from the group consisting of H, alkyl, aryl, alkenyl, benzyl, OH, NHR", CONHR" and COOR"; R" is selected from the group consisting of alkyl, aryl, alkenyl, and benzyl; and Y is selected from the group consisting of H, alkyl, aryl, alkenyl, benzyl and X.

- Mild, rinse-off antimicrobial cleansing compositions which provide improved immediate germ reduction during washing

The present invention relates to a rinse-off antimicrobial cleansing composition effective against Gram positive bacteria, Gram negative bacteria, fungi, yeasts. molds and viruses comprising from about 0.001% to about 5% of an antimicrobial active; from about 1% to about 80% of an anionic surfactant; from about 0.1% to about 12% of a proton donating agent; and from about 3% to about 98.899% of water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0; wherein the rinse-off antimicrobial cleansing composition has an One-wash Immediate Germ Reduction Index of greater than about 2.5. The invention also encompasses methods for reducing the number of germs from the skin using these products.

- Compositions for regulating skin appearance

The present invention relates to compositions for preventing or treating skin disorders using vitamin B3 compounds and polycyclic compounds. The present invention also relates to methods for regulating skin condition.

- Antimicrobial wipes which provide improved immediate germ reduction

The present invention relates to an antimicrobial wipe effective against Gram positive bacteria, Gram negative bacteria, fungi, yeasts, molds, and viruses comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active; from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant; from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent; and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0; wherein the antimicrobial cleansing composition an One-wash Immediate Germ Reduction Index of greater than about 1.3; and wherein the rinse-off antimicrobial cleansing composition has a Mildness Index of greater than 0.3. The present invention also relates to methods for removing germs from the skin using the antimicrobial wipes described herein.

- Carrier patch for the delivery of agents to the skin

A carrier patch for delivering agents locally to the skin or systemically via the skin. The patch comprises a pad having a lower surface area to which an adhesive is adhered, and a primary agent applied to discrete regions of the patch in a manner to minimize the deleterious effects of the adhesive on the primary agent. The invention further comprises a method for the discrete application of the agent to the patch, and a method of using the patch for the delivery of the agent to the skin.

- Transdermal compositions containing levosimendan

Transdermal administration of levosimenden or (-)-[[4-(1,4,5,6-tetahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrazono]p ropanedinitrile or a pharmaceutically acceptable salt thereof is disclosed. Transdermal preparations of levosimenden can be in the form of e.g. ointment, emulsion, lotion, solution, gel, cream, patch or transdermal delivery device including iontophoretic device.

- 2-amino-1,3-alkanediol compositions for inducing/stimulating hair growth and/or retarding hair loss

Topically applicable hair growth-/hair loss-affecting cosmetic/pharmaceutical compositions for treating mammalian subjects with hair or scalp disorders, comprise an effective amount of at least one 2-amino-1,3-alkanediol compound having the structural formula (I): ##STR1## formulated into a physiologically topically acceptable carrier medium therefor.

- Composition comprising an organopolysiloxane gel

A care composition containing, as gelling agent, at least one partially crosslinked, elastomeric solid organopolysiloxane combined with a fatty phase containing at least one polar oil and at least one cosolvent with a silicone structure comprising a chain which is pendent and/or at the end of a silicone structure, this chain being linear or branched and containing from 3 to 12 carbon atoms. This cosolvent is in particular volatile at ambient temperature, imparting coolness when applied.

- Hardenable orthopaedic support with improved configuration

An orthopaedic support assembly is formed of a double-knit type fabric material with spaced interwoven layers formed of high strength materials and an open-work matrix of filaments or threads interconnecting the layers. The fabric preferably includes high strength stiff filaments of fiberglass, carbon fibers, or aramids and thermoplastic material to facilitate heat bonding of cut edges. The fabric is impregnated with a water-hardenable material. The support material or product is packaged in a water-vapor impermeable package; and is opened and water is supplied to the fabric when it is applied to the part of the anatomy requiring support. The fabric may be included in a soft goods support including a water distribution network and straps to hold the support in place. The double-knit type material may be variable in thickness and may be three dimensional in its configuration. An orthopaedic support or splint may have an inner core material of the double-knit type fabric, an impermeable stretch bonded laminate layer on one side, and a microporous plastic layer on the other side to facilitate water activation of the core material.

- Disposable article having a responsive system including a mechanical actuator

Disposable articles such as diapers, incontinent briefs, diaper holders and/or inserts, training pants, feminine hygiene garments, tampons and the like having a responsive system. The article includes a sensor that detects an input and a mechanical actuator that is adapted to perform a responsive function upon bodily waste, a wearer, the article or a component or components thereof.

- Antiperspirant cream compositions having improved wash-off and antiperspirant efficacy

Disclosed are anhydrous antiperspirant cream compositions that have improved wash-off performance and good antiperspirant efficacy, which compositions have a penetration force value of from about 75 gram.multidot.force to about 500 gram.multidot.force, a delta stress value of from about 300 dyne/cm.sup.2 to about 8,000 dyne/cm.sup.2 as measured after extrusion of the composition through a shear force delivery means, and a static yield stress value of at least about 1,000 dyne/cm.sup.2 as measured after extrusion of the composition through a shear force delivery means. These compositions comprise from about 0.1% to about 20% by weight of a crystalline gellant, from about 10% to about 80% by weight of an anhydrous liquid carrier for the crystalline gellant wherein the anhydrous liquid carrier has a solubility parameter of from about 3 to about 13, from about 5% to about 35% by weight of a particulate antiperspirant active, and from about 0.001% to about 5% by weight of an anhydrous liquid surfactant which is selected from the group consisting of nonionic surfactant, amphoteric surfactant, and combinations thereof. Also disclosed are methods of using and making the compositions.

- .omega.-amino acid derivatives, processes of their preparation and their use

The invention relates to amino acid derivatives of general formula (I), wherein R.sup.1 is H or CH.sub.3, X is H or NR.sup.2 R.sup.3, wherein R.sup.2 is H, CH.sub.3, COH or COCH.sub.3 and R.sup.3 is H, CH.sub.3 or COO--Z wherein Z is R.sup.2 R.sup.3 NH.sup.+ CHR.sup.1 (CH.sub.2).sub.n COO(CH.sub.2).sub.m CH.sub.2 Y; Y is H, CH.sub.3 or NHR.sup.4, wherein R.sup.4 a COO--NH.sub.3.sup.+ CH.sub.2 (CH.sub.2).sub.m OOC(CH.sub.2).sub.n CH.sub.3, the meaning of group (CH.sub.2).sub.m being selected from alkyls, secondary alkyls, monocycloalkyls, bicycloalkyls and tricycloalkyls having from 4 to 15 carbon atoms and n having a value of from 3 to 14. .omega.-Amino acid derivatives of the invention are prepared by reacting a primary or secondary or monocyclic or bicyclic or tricyclic alcohol with the reaction product of an amino acid or an N-substituted amino acid with thionyl chloride, whereafter the amino group, which has been released by an amine, reacts with carbon dioxide providing a derivative of carbamic acid, or by directly reacting a primary or secondary or monocyclic or bicyclic or tricyclic alcohol with an N-substituted amino acid in the presence of a condensing agent giving the corresponding ester of the N-substituted amino acid. Thus produced compounds of formula (I) can be used as transdermal penetration enhancers. Incorporation of from 0.1 w/w percent to 5.0 w/w percent of a compound of the invention as a transdermal penetration enhancer in the vehicle of a topically applied pharmaceutical or cosmetic composition enhances transdermal penetration of pharmaceutical agents through the human or animal skin. Included further are transdermal penetration enhancers consisting of at least one compound of formula (I). ##STR1##

- Depigmenting cosmetic skin-care composition and use thereof

A cosmetic skin-care composition containing as the active principle a depigmentationally active combination of (a) an acidic mixture including (i) at least one .alpha.-hydroxylated acid or a derivative thereof, with the exception of ascorbic acid, and (ii) at least one compound selected from the group which consists of kojic acid, caffeic acid, azelaic acid, aminobutyric acid, fusaric acid, 5-hydroxy 2-hydroxymethyl-.gamma.-pyridone, and derivatives thereof, and (b) at least one active component of a plant extract from at least one plant selected from white mulberry, liquorice, skull cap, grapefruit, birch, heather, strawberry tree, bearberry, lemon, lettuce, oarweed, cucumber, ginseng, hop, sweet corn, feverfew, sage, soya, elder, spirulina, lime, ferocious aloe, yukinoshita, bloodwort, hoelen, wood rose, .alpha.-orizanol, burnet, ginkgo biloba, tanlex VB and Eclipsa alba, with the proviso that when the composition contains kojic acid and a liquorice extract, it contains at least one other plant extract component. The use of said composition for preparing a drug or in a cosmetic method is also disclosed.

- Liquid antimicrobial cleansing compositions

The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.1% to about 5% of an antimicrobial active, from about 8% to about 18% of an anionic surfactant, from about 2% to about 12% of a proton donating agent; from about 1% to about 30% of a lipophilic skin moisturizing agent; from about 0.1% to about 4% of a stabilizer; and from about 35% to about 88.8% of water. At least about 67% of the anionic surfactant comprises a mixture of Class A and Class C surfactant. The weight ratio of Class A surfactant to Class C surfactant ranges from about 5:1 to about 1:2. The composition is adjusted to a pH of from about 3.5 to about 4.5.

- Mild, rinse-off antimicrobial liquid cleansing compositions which provide improved residual benefit versus gram positive bacteria

The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.001% to about 5% of an antimicrobial active, from about 1% to about 80% of an anionic surfactant, from about 0.1% to about 12% of a proton donating agent; and from about 3% to about 98.899% of water, wherein the composition is adjusted to a pH of from about 3.0 to about 6.0, wherein the rinse-off antimicrobial cleansing composition has a Gram Positive Residual Effectiveness Index of greater than about 1.8, and wherein the rinse-off antimicrobial cleansing composition has a Mildness Index of greater than 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram positive bacteria using these products.

- Cleansing and conditioning products for skin or hair with improved deposition of conditioning ingredients

The present invention relates to a substantially dry, disposable, personal cleansing product useful for both cleansing and consistently conditioning the skin or hair. These products are used by the consumer by wetting the dry product with water. The product comprises of a water insoluble substrate, a lathering surfactant, and a conditioning component having a lipid hardness value of at least about 0.02 kg. This invention also encompasses methods for providing consistent deposition of conditioning agents to the skin or hair. The invention also encompasses methods for cleansing and conditioning the skin or hair using these products and to methods for manufacturing these products.

- Hydrophilic pressure sensitive hot-melt adhesives

A device for the release of substances from pressure sensitive hot-melt adhesives with a uniform or non-uniform distribution of said substances is characterized by the fact that the pressure sensitive hot-melt adhesive is hydrophilic and comprises at least one water-soluble, or at least water-swellable, polymer, at least one water-soluble, meltable adhesive resin, as well as substance to be released.

- Expression of an exogenous gene in a mammalian cell by use of a non-mammalian DNA virus having an altered coat protein

Disclosed are methods, nucleic acids, and cells for expressing an exogenous gene in a mammalian cell, involving introducing into the cell a non-mammalian DNA virus (e.g., a baculovirus) having an altered coat protein, the genome of which virus carries an exogenous gene, and growing the cell under conditions such that the gene is expressed. Also disclosed are methods for treating gene deficiency disorders, neurological disorders, or cancers in a mammal by (1) providing to a cell a therapeutically effective amount of a non-mammalian DNA virus having an altered coat protein, the genome of which virus carries an exogenous, therapeutic gene and (2) growing the cell under conditions such that the exogenous gene is expressed in the mammal.

- Thermal effect patch and the use thereof

The invention relates to a patch for application to the skin. The patch comprises: a reflecting layer that reflects the infrared radiation released by the human body, and between said reflecting layer and said face for application to the skin: a matrix made of a material having self-adhesive properties and comprising at least an acrylic or vinyl polymer whose adhesive properties increase with temperature over the range 20.degree. C. to 40.degree. C.; and in said matrix at least one active substance having an effect on the skin.

- Use of potentilla erecta extract in the cosmetic and pharmaceutical field

The invention relates to the use of an extract of the plant Potentilla erecta in the field of cosmetics and pharmacy, especially in dermatology. The invention more particularly relates to any application in which it is sought to reinforce the dermo-epidermal junction or to improve hair condition, by the improvement of the synthesis of collagen VII by keratinocytes and/or fibroblasts. In particular, these applications concern toning of the skin, diminishing of wrinkles or hair care. The invention also relates to a novel method of culture of cells, in particular of human fibroblasts or keratinocytes, for promoting the formation of collagen VII.

- Antimicrobial wipes which provide improved residual benefit versus gram negative bacteria

The present invention relates to an antimicrobial wipe comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active; from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant; from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent; and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0; wherein the antimicrobial cleansing composition has a Gram Negative Residual Effectiveness Index of greater than about 0.3. The invention also relates to these antibacterial wipes wherein the antimicrobial cleansing composition has a Mildness Index of greater than about 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram negative bacteria using these products.

- Cosmetic compositions containing polysaccharide/protein complexes

In an emulsion cosmetic composition for application to skin containing water and at least one surfactant, the improvement wherein the composition also contains a water soluble, protein polysaccharide complex ("PPC") having a net positive or negative charge, which is the reaction product of at least one protein and at least one anionic polysaccharide.

- Effervescent bath tablet, method of preparing it, and the use thereof

The present invention relates to a new type of solid balneological preparations for cosmetic, hygienic and therapeutic use, which has both the properties of a solid bath additive and those of liquid products, and is characterized especially by the addition of lipid components, vesicle forming lipids, tensides and, in some cases, mineral salts. Active components, adjuvants such as stabilizers, adsorbing substances, lubricants as well as smoothing and breakdown promoting agents may also be contained therein.

- Human kallikrein

The present invention provides a human tumor suppressor (HKALL) and polynucleotides which identify and encode HKAL,. The invention also provides expression vectors and host cells, agonists, antibodies, or antagonists. The invention provides methods for treating diseases associated with expression of HKALL.

- Particles, especially microparticles or nanoparticles, of crosslinked monosaccharides and oligosaccharides, processes for their preparation and cosmetic, pharmaceutical or food compositions in which they are present

Particles comprising an outer wall formed of one or more saccharide components selected from the group consisting of monosaccharides and oligosaccharides crosslinked by interfacial crosslinking in emulsion, preferably at room temperature, with a polyfunctional acylating crosslinking agent to produce ester linkages between the acylatable hydroxyl group(s) of the primary alcohol(s) of the saccharide component and the acyl groups of the polyfunctional acylating agent. These particles can be used for the manufacture of cosmetic, pharmaceutical and food compositions.

- Photostabilized sunscreen compositions comprising dibenzoylmethane compounds

Improvedly photostable, topically applicable cosmetic/dermatological sunscreen compositions well suited for enhanced photoprotection of human skin and/or hair against the damaging effects of UV-A and UV-B irradiation, particularly solar radiation, comprise (i) a photoprotecting effective amount of at least one dibenzoylmethane UV-screening compound, and (ii) an amount of at least one silane or organosiloxane substituted by a benzylidenecamphor functional group effective to photostabilize said at least one dibenzoylmethane UV-screening compound (i).

- Use of a two-phase composition for make-up removal of transfer-free make-up compositions

An applied make-up of long durability and/or a transfer-free make-up composition is removed from the skin by applying to the skin a composition consisting of an aqueous phase and an oily phase, which are distinct, to remove the make-up or transfer-free make-up.

- Elastomeric silicone terpolymer

Three-dimensional silicone elastomers having both polyether and higher alkyl functionality present in their molecules are in the form of networks of crosslinked linear siloxanes with polyether and olefin containing repeating units. Representative units are EO.sub.7 and EO.sub.12 for the polyether functionality, and C.sub.10, C.sub.12, and C.sub.18 alkyl functionality for the olefin. These gelled molecules are multipurpose type materials, and consequently they are capable of being useful in a variety of multiphased formulations in personal and health care applications.

- Composition for the cosmetic and/or pharmaceutical treatment of the upper layers of the epidermis by topical application to the skin, and corresponding preparation process

Composition comprising biodegradable nanoparticles encapsulating oils which are active and/or which contain an active ingredient having a cosmetic and/or pharmaceutical action in the upper layers of the epidermis. The nanoparticles are preferably prepared from a polymer of (C.sub.2 -C.sub.12) alkyl cyanoacrylate.

- Use of a substance P antagonist in a cosmetic composition, and the composition thus obtained

The invention concerns the use of a substance P antagonist in a cosmetic composition used to treat sensitive skin. More specifically, the invention relates to a substance P antagonist used to prevent and/or combat skin irritations, desquamation, erythemas, sensations of dysesthesia/overheating, or pruritus of the skin.

- Ceramide compounds, process of preparation and use

The present application relates to novel ceramide compounds to their process of preparation and to their use in cosmetics or in pharmaceuticals, in particular for treating and caring for the skin, hair, nails and eyelashes.

- Powdered cosmetic and/or dermatological lotion and its use

A cosmetic and/or dermatological lotion comprising an aqueous phase and a powdered phase, the powdered phase comprising at least one active powder and hollow particles based on at least one acrylic or methacrylic polymer or copolymer, the aqueous phase being present in an amount ranging from 90 to 99.99% by weight with respect to the total weight of the lotion. The inventive lotion has the advantage of being soft on application and of exhibiting a powdered phase which does not become clogged. The lotion may be used for caring for, cleaning, removing make-up from and/or coloring the skin, mucous membranes and/or scalp.

- Hydrophilic adhesive masses

A hydrophilic adhesive mass contains 0.05 to 10 wt. % of a copolymer of an aminoalkyl (meth)acrylate and an alkyl (meth)acrylate. This hydrophilic adhesive mass is excellent in adhesiveness, and especially when combined with a pharmacologically active ingredient, is suitable for use in providing hydrophilic plasters.

- Non- or minimally invasive monitoring methods using particle delivery methods

Methods for sampling an analyte present in a biological system are provided. The methods entail use of particle delivery methods to obtain a sample of an analyte of interest from the system.

- Conditioning/styling terpolymers

What is described herein are conditioning/styling terpolymers of vinylpyrrolidone (VP), dimethylaminopropyl methacrylamide (DMAPMA) and C.sub.9 -C.sub.24 alkyl dimethylaminopropyl methacrylic acid quaternized monomers (QDMAPMA), in a defined compositional range. Hair and skin care compositions which include these terpolymers exhibit advantageous low tackiness and high humidity resistance.

- Self-foaming cream

A self-foaming composition in the form of a post-foaming, pressurizable oil-in-water emulsion comprising: (A) at least 5% by weight, relative to the total weight of the composition, of a fatty phase comprising at least one cosmetic oil, (B) a gelling system comprising at least one emulsifying polymer which is selected from the group consisting of: (1) crosslinked homopolymers formed from at least one cationic or anionic monomer containing ethylenic unsaturation selected from the group consisting of ammonium (meth)acrylate; 2-acrylamido-2-methylpropanesulfonic acid as well as its salts, dialkylaminoalkyl (meth)acrylates, dialkylaminoalkyl (meth)acrylamide and its quaternary salts or acids, wherein the crosslinking agent which forms the crosslinking contains ethylenic polyunsaturation, and (2) crosslinked copolymers formed from at least one cationic or anionic monomer containing ethylenic unsaturation, from at least one nonionic comonomer and from a crosslinking agent containing ethylenic polyunsaturation; and (C) water.

- Leave-on antimicrobial compositions

The present invention relates to a leave-on antimicrobial composition comprising from about 0.001% to about 5.0%, by weight of the leave-on antimicrobial composition, of an antimicrobial active; from about 0.05% to about 10%, by weight of the leave-on antimicrobial composition, of an anionic surfactant; from about 0.1% to about 10%, by weight of the leave-on antimicrobial composition, of a proton donating agent; and from about 0% to about 99.85%, by weight of the leave-on antimicrobial composition, water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0. The invention also encompasses methods for moisturizing, reducing the number of germs on the skin, and decreasing the spread of transient Gram negative and Gram positive bacteria using the leave-on antimicrobial compositions described herein.

- Percutaneous delivery system

The invention relates to a substantially homogenous liquid composition capable of percutaneous delivery of one or more physiologically active agents, the composition including a rate modulating polymer, a volatile solvent and at least one physiologically active agent, said rate modulating polymer being selected to enable modulation of the rate of delivery of said physiologically active agent. Methods of percutaneous delivery of active agents and of prophylactic or therapeutic antimicrobial, antifungal or antiviral treatment using the compositions of the invention are also described.

- Self-tanning composition comprising carmine

The present invention relates to a composition comprising self-tanning agent and carmine, cosmetic products comprising such composition and a cosmetically acceptable carrier, and methods of using such products.

- Photoprotective/cosmetic compositions comprising camphorsulfonic acid, bisresorcinyltriazine and benzoazolyl/benzodiazolyl sunscreens

Topically applicable sunscreen/cosmetic compositions well suited for the synergistically enhanced photoprotection of human skin and/or hair against the damaging effects of UV-irradiation, particularly solar radiation, comprise synergistically UV-photoprotecting effective amounts of each of (a) benzene-1,4-bis(3-methylidene-10-camphorsulfonic acid), optionally in neutralized form thereof, (b) at least one bisresorcinyltriazine compound, and (c) at least one compound containing at least two benzoazolyl groups or at least one benzodiazolyl group, formulated into a topically applicable, cosmetically acceptable vehicle, diluent or carrier therefor.

- Photoprotective/cosmetic compositions comprising benzotriazole and benzoazolyl/benzodiazolyl sunscreens

Topically applicable sunscreen/cosmetic compositions well suited for the synergistically enhanced photoprotection of human skin and/or hair against the damaging effects of UV-irradiation, particularly solar radiation, comprise synergistically UV-photoprotecting effective amounts of each of (a) at least one benzotriazole compound, and (b) at least one compound containing at least two benzoazolyl groups and/or at least one benzodiazolyl group, formulated into a topically applicable, cosmetically acceptable vehicle, diluent or carrier therefore.

- Process for the extraction of an active principle from tournesol, active principle obtained, and composition active against aging of the skin

The object of the invention covers an extraction process for an active principle having anti-radical and anti-glycolation action to counter cutaneous aging. The invention also covers the obtained active principle, the cosmetic compositions using this active principle, and a process for countering aging.

- Liquid antimicrobial cleansing compositions which provide residual benefit versus gram negative bacteria

The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.001% to about 5% of an antimicrobial active, from about 1% to about 80% of an anionic surfactant, from about 0.1% to about 12% of a proton donating agent; from about 0.1% to about 30% of a deposition aid; and from about 3% to about 98.8% of water, wherein the composition is adjusted to a pH of from about 3.0 to about 6.0, wherein the rinse-off antimicrobial cleansing composition has a Gram Negative Residual Effectiveness Index of greater than about 0.3, and wherein the rinse-off antimicrobial cleansing composition has a Mildness Index of greater than 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram negative bacteria using these products.

- 2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same

The present invention relates to a compound of the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each a hydrogen or an acyl, a pharmaceutically acceptable acid addition salt thereof or a hydrate thereof; a pharmaceutical comprising this compound; a pharmaceutical composition comprising this compound and a pharmaceutically acceptable carrier; and 2-amino-2-(2-(4-(1-hydroxy-5-phenylpentyl)phenyl)ethyl)propane-1,3-diol or 2-amino-2-(2-(4-formylphenyl)ethyl)propane-1,3-diol, the derivatives of the two compounds whose amino group and/or hydroxy group are(is) protected or a salt thereof. The compound of the present invention shows superior immunosuppressive action with less toxicity and higher safety, and is useful as a drug for prevention or suppression of rejection of organs or bone marrow transplantation, or as a drug for prevention or treatment of various autoimmune diseases or allergic diseases.

- Use of at least an Irvingia gabonensis extract in a cosmetic and/or pharmaceutical product

The use of at least an Irvingia gabonensis extract, in particular Irvingia gabonensis seeds, as active agent(s) for preparing a cosmetic and/or pharmaceutical product for topical use on the skin and/or superficial body growth, the extract being present between 0.05% and 50.00% by weight.

- Cosmetic, dermatological and pharmaceutical use of an extract of Terminalia catappa

The invention concerns the use of an extract of the Terminalia catappa plant, as well as cosmetic, dermatological and pharmaceutical compositions containing such an extract. The invention also concerns the use of an extract of the Terminalia catappa plant with other active compounds, in a cosmetic, dermatological and/or pharmaceutical composition for external topical use for the skin or superficial body growth.

- Antipruriginous cosmetic and/or pharmaceutical compositions consisting of one or several light local anaesthetics and one or several astringent substances

The present invention relates to antipruritic cosmetic and/or pharmaceutical compositions for use on human or animal skin, comprising one or more mild local anesthetics, one or more astringents and/or, if appropriate, a substance having an antiinflammatory action.

- Leave-on antimicrobial compositions which provide improved immediate germ reduction

The present invention relates to a leave-on antimicrobial composition comprising from about 0.001% to about 5% of an antimicrobial active; from about 0.5% to about 10% of an anionic surfactant; from about 0.1% to about 10% of a proton donating agent, wherein the proton donating agent is such that the composition is essentially free of C.sub.4 -C.sub.20 alkyl fatty acid; and from about 0% to about 98.85% of water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0; wherein the leave-on antimicrobial composition has a One-wash Immediate Germ Reduction Index of greater than about 50%; and wherein the leave-on antimicrobial composition has a Mildness Index of greater than 0.3. The invention also encompasses methods for moisturizing skin, reducing germs on the skin, and providing residual effectiveness versus Gram positive bacteria using these products.

- Methods of regulating skin appearance with vitamin B3 compound

The present invention relates to topical compositions comprising a vitamin B.sub.3 compound which are useful for regulating skin condition, especially for regulating the signs of skin aging.

- Diamine alkylene diacetic or triacetic acid derivatives, preparation method, use in cosmetic and pharmaceutical compositions and compositions containing them

Novel alkylenediaminediacetic acid or alkylenediaminetriacetic derivatives of formula (I): ##STR1## or an organic or inorganic salt thereof, their process of preparation, and their use in cosmetic and pharmaceutical compositions, such as for protecting the body against oxidative stress are discussed.

- Pentafluoropropane blowing agent-containing resin blend for use in making integral skin foams

It has been found that non-chlorinated pentafluoropropane blowing agents may be used alone or in combination with water in flexible integral skin foams. For example, foams prepared from a resin blend incorporating 1,1,1,3,3-pentafluoropropane (HFA-245fa) alone or in combination with water exhibit physical characteristics such as resistance to abrasion and cracking on flex comparable to conventional chlorinated fluorocarbon blown foams. Such foams made using the resin blend of the present invention are suitable for use in many applications including, for example, shoe soles.

- Benzimidazole/benzofuryl-benzazole silicon compounds and UV-photoprotective compositions comprised thereof

Novel liposoluble and photostable N-substituted benzimidazole/benzofuryl-benzazole silicon-containing compounds are conspicuously excellent UV-absorbers and are conveniently formulated, e.g., into topically applicable sunscreen/cosmetic compositions well suited for the UV-photoprotection of human skin and/or hair.

- Cosmetic composition

An antiperspirant or deodorant cosmetic composition suitable for topical application to the human skin, comprising: i. an antiperspirant or deodorant active; ii. a moisturising cream; and optionally iii. a carrier for the antiperspirant or deodorant active.

- Cosmetic cleansing and skin care preparation containing plant and algae extracts

The invention relates to a cosmetic cleansing and skin care preparation which is particularly suitable for extremely greasy pubertal skin and exhibits very good sebostatic effectiveness. The preparation contains 0.25-5 wt. % of a combination comprising 5-40 wt. % of an alga laminaria saccharina extract; 10-60 wt. % of lilium candidum root extract; 10-50 wt. % glycyrrehetinic acid as a natural extract of glycyrrhiza glabra. The preparation also contains 99.75 to 95 wt. % cosmetic auxiliary agents and carriers, optionally mixed with additional active substances.

- Polar solvent-in-oil emulsions and multiple emulsions

One composition is a non-aqueous polar solvent-in-oil emulsion containing a non-aqueous polar solvent phase dispersed in a silicone oil continuous phase by an emulsifier. A second composition is a non-aqueous polar solvent-in-oil-in-water multiple emulsion of the type PS.sub.1 /O/W which contains a non-aqueous polar solvent phase PS.sub.1 dispersed in a silicone oil as a first continuous phase of a primary emulsion PS.sub.1 /O by an emulsifier. The primary emulsion PS.sub.1 /O is dispersed in a second continuous aqueous phase W to form multiple emulsion PS.sub.1 /O/W. A third composition is a non-aqueous polar solvent-in-oil-in-non-aqueous polar solvent multiple emulsion of the type PS.sub.1 /O/PS.sub.2 which contains a non-aqueous polar solvent phase PS.sub.1 dispersed in a silicone oil as a first continuous phase of a primary emulsion PS.sub.1 /O by an emulsifier. The primary emulsion PS.sub.1 /O is dispersed in a second continuous non-aqueous polar solvent phase PS.sub.2 to form multiple emulsion PS.sub.1 /O/PS.sub.2.

- Antiwrinkle cosmetic/pharmaceutical compositions comprising iridaceae extracts

Cosmetic/pharmaceutical compositions, well suited for the treatment of unwanted skin wrinkles, e.g., for visibly reducing human skin wrinkles, comprise an effective antiwrinkle amount of at least one extract of at least one member of the Iridaceae family that relaxes and/or loosens cutaneous and/or subcutaneous tissue, formulated into a cosmetically/pharmaceutically acceptable excipient or carrier therefor.

- Aqueous compositions comprising a lipid and a lanolin-derived surfactant, and their use

An aqueous composition comprising, in addition to water: (a) one or more surfactant materials selected from polyoxyalkylene condensate derivatives of lanolin or a lanolin derivative; and (b) a lipid component comprising one or more lipid materials, especially lanolin or a lanolin derivative, present as particles emulsified by the said one or more lanolin-derived surfactant materials and having a median particle size of less than about 5 .mu.m, especially from 0.01 to 1 .mu.m. The compositions have very good physical stability and are particularly useful as carriers for transdermal delivery of pharmaceutical actives to the human skin.

- UV protection compositions

The present invention relates to compositions suitable for providing protection against the harmful effects of ultraviolet radiation. The composing provide excellent efficiency, broad spectrum UV efficacy, and photostability. Methods of use for these compositions are also disclosed. The present compositions comprise: a) an effective amount of a UVA-absorbing dibenzoylmethane sunscreen active; b) an effective amount of a styrene derivative, having the formula ##STR1## wherein at least one of R.sub.1, R.sub.2, and R.sub.3 is an electron-withdrawing substituent, provided that R.sub.1 is other than an aryl or a methyl, that R.sub.2 and R.sub.3 are each other than a ketone, and that R.sub.2 and R.sub.3 together do not form a camphor group; wherein the remaining substituents of R.sub.1, R.sub.2, and R.sub.3 that are not electron-withdrawing substituents are selected from the group consisting of H and electron-donating substituents; and wherein R.sub.4 is selected from the group consisting of H, electron-donating substituents other than ethers, and electron-withdrawing substituents other than cyanos; and c) a suitable carrier.

- Active composition for combating the effects of the cold and cosmetic product containing this composition

Topical active composition against the effects of cold, which is constituted by 0.1% to 30% by weight of polysaccharides comprising at least glycogen and at least one mucilage extracted from conifer, by 45% to 95% by weight of vegetable proteins extracted from legumes and by 0.1% to 25% by weight of amino acids selected from the group consisting of threonine, serine, proline and alanine.

- Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering

Compositions for tissue engineering and drug delivery have been developed based on solutions of two or more polymers which form semi-interpenetrating or interpenetrating polymer networks upon exposure to active species following injection at a site in a patient in need thereof. The polymers crosslink to themselves but not to each other; semi-interpenetrating networks are formed when only one of the polymers crosslink. The resulting viscous solutions retain the biologically active molecules or cells at the site of injection until release or tissue formation, respectfully, occurs. As a result of studies conducted with polymer-cell suspensions forming interpenetrating polymer networks, it has been determined that polymer solutions can be formulated wherein the active species is provided by exposure of the polymer solution to an exogenous souce of active species, typically electromagnetic radiation, preferably light. Studies demonstrate that light will penetrate through skin, body fluids (such as synovial fluid) and membranes and polymerize the polymer solutions. The polymer solutions can be crosslinked ionically or covalently, to form a hydrogel, semi-interpenetrating polymer network or an interpenetrating polymer network.

- Hormonal agent for skin treatment

The pharmaceutical composition, especially for treating skin with seborrhea, Acne vulgaris and androgonically conditioned alopecia, contains a hormonal agent including the gestogen, dienogest, or a combination of dienogest and an estrogen, as active ingredient. Methods for treatment of this type of skin condition include topical application of the composition including the dienogest which results in an outstanding sebosuppression, a drastic reduction of androstandiol glucuronide and a moderate competitive blockage of androgen receptor sites. Galenic formulations are described which limit and/or prevent the permeation of the active ingredient through the skin. The pharmaceutical preparation including the dienogest and conventional dermatologically acceptable carrier and auxiliary substances in the described galenic formulation advantageously provides a drastic reduction in androstandiol glucuronide and moderate androgen receptor blockage without passing through the skin barrier so that systemic effects including side reactions are substantially prevented.

- Adhesive-matrix patch

The invention relates to a patch comprising a matrix made of a material having self-adhesive properties to being applied to the skin. The patch includes a permeable structure completely embedded in said matrix close to its surface so as to modify the overall adhesive power thereof.

- Device for tissue engineering bone

A device for bone tissue engineering is described which comprises a scaffold material consisting of a bioactive, osteoconductive and bone-bonding segmented thermoplastic copolyester and cultured osteogenic or osteoprogenitor cells, especially bone cells. The copolyester consists essentially of a multiplicity of recurring long-chain ester units and short-chain ester units, the long-chain ester units comprising from 35 to 80% by weight of the copolyester and being represented by the formula and the short-chain ester units being represented by the formula wherein L is a divalent group remaining after removal of terminal hydroxyl groups from a poly(oxyalkylene) glycol with an average molecular weight of between 300 and 3000; R is a divalent group remaining after removal of carboxyl groups from a dicarboxylic acid having a molecular weight of less than 300; Q is an alkylene group having 1-6 carbon atoms and/or a cyclohexylene of phenylene group; and E is an alkylene group having 2-6 carbon atoms.

- Composition in the form of an oil-in-water emulsion comprising an acrylic terpolymer and its uses, in particular its cosmetic uses

A composition in the form of an oil-in-water emulsion comprising, in a physiologically acceptable medium, an oily phase dispersed in an aqueous phase and comprising at least one acrylic terpolymer obtained from the polymerization of a carboxylic acid monomer having .alpha.,.beta.-ethylenic unsaturation, a non-surface-active monomer comprising ethylenic unsaturation other than (a), and a non-ionic urethane monomer which is the reaction product of a monohydric non-ionic amphiphilic compound with an isocyanate comprising monoethylenic unsaturation, in which the terpolymer/oily phase ratio by weight ranges from 1/50 to 1/125. The composition is particularly suited for cosmetic and/or dermatological applications.

- Method of depigmenting and/or bleaching skin and/or body hair or head hair

The use, in a topical cosmetic composition, or for the manufacture of a topical dermatological composition, intended for depigmenting and/or bleaching human skin, body hair or head hair, of at least one compound comprising a phenyloxime fragment.

- Water-in-oil emulsion containing fused silica and a polysaccharide alkyl ether

A water-in-oil emulsion is provided having a liquid fatty phase and an aqueous phase, wherein the liquid fatty phase contains a fumed silica and at least one polysaccharide alkyl ether formed of units containing at least two different saccharide rings, each unit containing at least one hydroxyl group substituted with a hydrocarbon-based chain, and from 0% to 5% by weight, relative to the total weight of the emulsion, of at least one emulsifying surfactant, and the liquid fatty phase contains at least one medium which is a solvent for the polysaccharide alkyl ether, that is useful in particular in the cosmetics and/or dermatological fields.

- Self-tanning dihydroxyacetone formulations having improved stability and providing enhanced delivery

A composition is provided which is useful for self-tanning skin coloring and is characterized by improved stability, which comprises from about 0.5% to about 20.0% by weight, based on total weight of said composition, of a self-tanning skin coloring agent subject to chemical instability, which is preferably dihydroxyacetone; from about 2.0% to about 40.0% by weight of a polyethoxyglycol, which is preferably ethoxydiglycol; and from about 0.1% to about 15.0% by weight of a polyol comprising a polyhydric compound having at least three hydroxyl groups and at least three carbon atoms, which is preferably D-sorbitol. The self-tanning composition may further optionally contain from about 0.1% to about 8.0% by weight of a water soluble dihydroxyl compound having at least two, and up to eight carbon atoms, which is preferably ethylene glycol; and the self-tanning composition may still further optionally contain an acidifying agent in amount sufficient to maintain the pH of said total composition at from about 3.5 to about 4.5, which is preferably sorbic acid. Cosmetologic products and methods of tanning are also provided.

- Antiperspirant compositions

Antiperspirant compositions herein comprise an antiperspirant active, a carrier and a structurant for the carrier which comprises an effective concentration of a combination of at least one sterol and at least one sterol ester, to form a solid or a soft solid. The compositions can be anhydrous and in the form of a suspension of antiperspirant active, or can comprise aqueous emulsions. A particularly suitable sterol comprises .beta. sitosterol and a particularly preferred sterol ester comprises oryzanol. Preferably the mole ratio of sterol to sterol ester is in the range of 3:1 to 1:2.

- Topical Products as prophylactic of curative agents for bacterial skin infections

The present invention relates to topical products intended for use as prophylactic or curative agents for bacterial skin infections, containing at least one polymeric complex substantially consisting of hydrogen peroxide, a suitable polymer for the complex formation thereof, possibly another bactericidal compound and possibly a metal salt or a metal colloid.

- Structured water for enhanced moisturization

The invention relates to a cosmetic or pharmaceutical composition containing a moisturizing effective amount of S water, as well as a method for enhancing the moisturization capacity of a skin care composition containing an aqueous component comprising incorporating S water as all or part of the aqueous component

- Acidified composition for topical treatment of nail and skin conditions

This invention relates to a method for topical treatment of human nail and skin diseases, including fungal infections, bacterial infections, and psoriatic infections. In addition, this invention relates to a method of treating the general condition of human nails including their strength, rate of growth and appearance. More particularly, the invention relates to an acidified composition and methods of using said composition. Still further the invention relates to an acidified lacquer useful in treating human nails and skin.

- Use of water-soluble copolymers as active ingredients in cosmetics

A cosmetic composition comprising water-soluble copolymer, which as characteristic structural elements comprises a) vinylcarboxamide units of the general formula I ##STR1## where R.sup.1 and R.sup.2 independently of one another are H, alkyl, cycloalkyl, aryl or aralkyl, and b) units of the general formula II ##STR2## where A is a chemical bond or an alkylene group, the radicals R.sup.3 independently of one another are H, alkyl, cycloalkyl, aryl or aralkyl, or together with the nitrogen atom to which they are bonded, form an unsubstituted, mono- or polysubstituted, five- to seven-membered, heterocyclic, aromatic or nonaromatic ring, which if appropriate contains one or two further heteroatoms, selected from among O, N and S, it being possible for the heterocyclic ring to be fused to a further five- or six-membered, aromatic or nonaromatic ring, R.sup.4 is H, alkyl or aralkyl.

- High speed magnetic thrust disk

The present invention contemplates an internally reinforced high-speed magnetic thrust disk. In one embodiment the internally reinforced composite thrust disk comprises a plurality of high strength fibers coupled together by a soft magnetic alloy. Further, in one aspect the disk having internally reinforced zones for controlling bore growth and counteracting forces associated with the reaction between the stator and the rotor of the electromagnetic thrust bearing system.

- Method for on-mold coating molded articles with a coating powder as a liquid gel coat replacement

Method for on-mold surface coating fiberglass-reinforced molded articles during their manufacture with environmentally friendly and physiologically safe thermosetting unsaturated polyester on-mold coating powders which serve as replacements for liquid gel coats. The thermosetting coating powders employed are adapted to cure at low temperatures to avoid causing thermal damage to the heat sensitive plastic molds which must be reused over and over again, and to cure in the presence of atmospheric oxygen to enable over coating with liquid fill resins and fiberglass, which constitute the bulk of the finished article, without having the fill resins bleed through the powder coating film and detrimentally affect the overall quality of the surface finish.

- Transfer-free make-up or care composition containing an organopolysiloxane and a fatty phase

A transfer-free composition containing an organopolysiloxane and a fatty phase containing at least one oil which is volatile at room temperature, particularly a make-up or care composition for the lips or a make-up foundation composition both for the human face and the body. This composition is gentle to apply, spreads easily, is non-sticky and does not dry the skin or the lips.

- Liquid crystalline phase drug delivery vehicle

The composition disclosed herein comprises about 55 to about 90 weight percent of a monoglyceride component comprising a monoglyceride having an acyl chain of 12 to 22 carbons, about 5 to about 35 weight percent of an acetylated monoglyceride component comprising an acetylated monoglyceride having an acyl chain of 12 to 22 carbons, and about 2 to about 40 weight percent water. The present composition is a liquid crystalline phase composition at a temperature of about 20 to about 80.degree. C., preferably a cubic liquid crystalline gel.

- Sunscreen composition containing sol-gel microcapsules

The present invention generally relates to safe and stable sunscreen compositions comprising of at least one sunscreen active ingredient in the form of an inert sol-gel microcapsules encapsulating ultraviolet absorbing compounds in any acceptable cosmetic vehicle. The composition according to the present invention can comprise several ultraviolet absorbers that may be encapsulated in the same sol-gel microcapsule or in different capsules. The encapsulation of the ultraviolet absorbers reduces or even prevents the contact between the sunscreen compounds and the human tissue, thus reducing various adverse effects that are associated with the use of sunscreens, such as photoallergy and phototoxicity, and makes the composition safer for use. The encapsulation also reduces or even prevents cross reactivity between the sunscreen compounds and the packaging material and between the sunscreen compounds and any other component present in the composition, thus enhance the compositions stability. The hydophobicity/hydrophilicity character of the sol-gel microcapsules can be controlled by selecting suitable sol-gel precursors and suitable reaction conditions and can be chosen to be compatible with the cosmetic vehicle to be used in the sunscreen composition, thus, the present invention facilitates an easy incorporation of the composite sol-gel encapsulated sunscreen in all types of cosmetic vehicles including oil free compositions, with no necessary steps of heating or high shear forces. The sunscreen compositions of the present invention can comprise any acceptable UVA and/or UVB absorbing compounds at any desired ratio to obtain a desired accumulative ultraviolet screening spectrum.

- Cosmetic compositions comprising a film-forming polymer

A composition containing a physiologically acceptable medium of oil-in-water or water-in-oil type, thickened by an associative polyurethane. The composition has viscoelastic properties allowing it to recover its initial appearance after each use. The composition may be used as, for example, a makeup foundation.

- .alpha.-amides of L-amino acid as fragrance precursors

Disclosed are .alpha.-amides of L-amino acids that produce fragrance or attenuate or mask malodor. In particular, threonine amides, glycine amides, serine amides, and alanine amides can be used in the invention. Such .alpha.-amides of L-amino acids are useful for generating pleasant fragrances or attenuating or masking malodor upon cleavage of the .alpha.-amides of L-amino acids by bacteria in axillae. The .alpha.-amides of L-amino acids can be incorporated into skin treatment compositions and personal care products, such as deodorants, body sprays and antiperspirants, and used in methods for producing fragrance or attenuating or masking malodor.

- Cosmetic raw materials, cosmetic products, and methods of manufacturing cosmetic products

A cosmetic raw material provides uniform dispersions of silicone oils and crosslinked silicone particles in cosmetic products. The cosmetic products consist of the cosmetic raw material combined with other types of cosmetic raw materials. This provides pleasant sensations of touch with the fingers and skin, improved rubbing properties, and sensation in their use. The method of manufacturing the cosmetic products has a high efficiency. The cosmetic raw material is made from a silicone oil emulsion containing crosslinked silicone particles having an average diameter of 0.05-100 .mu.m which are contained in silicone oil drops having an average diameter of 0.1-500 .mu.m, the drops in turn being dispersed in water. The diameter of the crosslinked silicone particles is less than the diameter of the silicone oil drops.

- Methods of regulating skin appearance with vitamin B3 compound

The present invention relates to topical compositions comprising a vitamin B.sub.3 compound which are useful for regulating skin condition, especially for regulating the signs of skin aging.

- Intestinal absorption of nicotine to treat nicotine responsive conditions

A delayed and sustained release composition of an additive and/or toxic agent such as nicotine is delivered systemically in therapeutic amounts while avoiding the peak plasma levels which gives rise to addiction and/or toxic side effects. The composition is delivered for absorption predominantly from the colon.

- Antiperspirant compositions

An antiperspirant composition is a structured emulsion of a continuous phase containing water-immiscible liquid carrier plus a structurant, and a disperse phase which is a solution of antiperspirant active in water or a mixture of water and water-soluble solvent. The structurant is a fully or partially esterified saccharide. The compositions give low visible residue when applied to skin or to clothing.

- Therapeutic/cosmetic compositions comprising bradykinin antagonists for treating sensitive human skin

Topically applicable pharmaceutical/dermatological/cosmetic compositions well suited for the therapeutic treatment or care of sensitive human skin, hair, mucous membranes, nails and/or the scalp, in particular for reducing or avoiding the skin-irritant side effects of a variety of bioactive agents, for example the .alpha.-hydroxy and .beta.-hydroxy acids, comprise a therapeutically/cosmetically effective amount of at least one bradykinin antagonist.

- Dermatological patch

A dermatological patch for removing keratotic plugs from pores of the skin to improve the health and appearance of skin. The patch comprises a pad having a lower surface having a polymeric adhesive composition, which does not require premoisturization of the patch by the user to effect its operation. The patch can be of different shapes, formed of transparent, clear or colored material so as to enhance its cosmetic appearance on the skin, and contain additives to enhance the use of the patch for improving skin health.

- Cosmetic/pharmaceutical compositions comprising microorganism culture media

Cosmetic/pharmaceutical compositions, suitable for cosmetic applications and/or for treating a wide variety of mammalian disorders or disease states, comprise an effective active principle amount of a clarified and stabilized culture medium for at least one non-photosynthetic filamentous bacterium, advantageously belonging to the genera Beggiatoa, Vitreoscilla, Flexithrix or Leucothrix, formulated into a cosmetically/pharmaceutically acceptable vehicle, diluent or carrier therefor.

- Fluid composition in the form of an oil-in-water emulsion comprising an acrylic terpolymer and its uses, in particular its cosmetic uses

A fluid composition in the form of an oil-in-water emulsion comprising, in a physiologically acceptable medium, an oily phase dispersed in an aqueous phase and comprising up to 0.5% by weight of active material with respect to the total weight of the composition of at least one acrylic terpolymer obtained from a carboxylic acid comprising .alpha.,.beta.-ethylenic unsaturation, from a non-surface-active monomer comprising ethylenic unsaturation other than (a), and from a non-ionic urethane monomer which is the reaction product of a monohydric non-ionic amphiphilic compound with an isocyanate comprising monoethylenic unsaturation. The composition may be used, for example, for caring for, removing make-up from, cleansing and/or scenting the skin, hair and/or lips. The composition may also be used for impregnating fabrics intended for cleansing and/or removing make-up from the skin, lips and/or eyes.

- Solid foaming pulverulent composition to be hydrated for caring for or cleaning the skin

The invention relates to a foaming pulverulent composition for cleaning and/or caring for the skin. The composition includes a cosmetically acceptable binder and a pulverulent filler which is insoluble in the binder and which is present in an amount sufficient to structure the composition and to confer on it the appearance of a deformable solid in which the binder is trapped. The pulverulent filler includes solid particles of thermoplastic polymer and at least one surfactant in pulverulent form. The composition foams when it is hydrated.

- Fatty acid esters as bioactive compounds

Compounds of structure (I), and when for use in therapy: where R.sub.1 is an acyl group derived from a C.sub.16-30 fatty acid with two or more cis or trans double bonds and particularly an n-6 or n-3 series EFA or conjugated linoleic acid, or columbinic acid, or parinaric acid and R.sub.2 is as R.sub.1 the same or different, or any other nutrient, drug or other bioactive residue released as the active in the body and R.sub.3 is either hydrogen, fully hydrocarbon, or containing heteroatoms, preferably an alkyl group particularly a C.sub.1 -C.sub.4 alkyl group. ##STR1##

- Photoprotective/cosmetic compositions comprising bisresorcinyltriazine and benzoazolyl/benzodiazolyl

Topically applicable sunscreen/cosmetic compositions well suited for the synergistically enhanced photoprotection of human skin and/or hair against the damaging effects of UV-irradiation, particularly solar radiation, comprise synergistically UV-photoprotecting effective amounts of each of (a) at least one bisresorcinyltriazine compound, and (b) at least one compound containing two benzoazolyl groups, or at least one benzodiazolyl group, formulated into a topically applicable, cosmetically acceptable vehicle, diluent or carrier therefor.

- Cosmetic compositions

A cosmetic composition preferably an antiperspirant composition, in solid or soft-solid form has a continuous phase which contains a water-immiscible liquid carrier and also contains a structurant which is partially or fully esterified cellobiose of the formula ##STR1## wherein each Z is independently hydrogen or an acyl group of the formula ##STR2## where R denotes a hydrocarbyl group containing from 4 to 22 carbon atoms. Not more than half of the Z groups are hydrogen.

- Method of treating topical angiogenesis-related disorders

The present invention relates to a method of inhibiting angiogenesis in mammalian tissue which comprises supplying to the tissue a composition comprising an effective amount of epigallocatechin-gallate, epicatechin gallate or a combination thereof. The method is particularly useful in the treatment of angiogenesis-related skin conditions in which the catechin is applied topically, such as the treatment of various skin cancers, psoriasis, spider veins or undereye circles.

- Dissolution liquid for drug in iontophoresis

A drug held or supported by an interface comprising a porous matrix is dissolved with a drug dissolution liquid containing a humectant, and the drug is transdermally delivered by iontophoresis. The humectant includes e.g. glycerin and other polyhydric alcohols, sugar alcohols, proline and other amino acids and acidic mucopolysaccharides. The concentration of the humectant may be about 1 to 50% by weight, and the concentration of proline or other amino acid or its salt may be about 1 to 30% by weight. The drug includes (1) a physiologically active peptide or protein with a molecular weight of 100 to 30,000 or (2) a nonpeptide physiologically active compound with a molecular weight of 100 to 1,000.

- Compositions containing lipid compounds derived from sphingoid bases, their process of preparation

The invention encompasses compounds corresponding to the formula ##STR1## in which R.sub.1 denotes a C.sub.1 -C.sub.31, preferably C.sub.9 -C.sub.25, hydrocarbon-comprising radical, in particular a saturated or unsaturated, linear or branched, C.sub.1 -C.sub.31, preferably C.sub.9 -C.sub.25, alkyl radical which can be substituted by one or more optionally esterified hydroxyls; and OR.sub.2 denotes a cholesteryl radical; the said compounds being in the form of a pure enantiomer or in the form of a mixture of isomers. The invention also relates to their process of preparation and to their use, in particular for the treatment and care of the skin, hair, nails and eyelashes, in cosmetics or in dermatology.

- Use of inhibitors of the activity of retinoic acid for treating sensit ive skin and/or acute damage induced by UV radiation

The invention concerns tye use of a inhibitor of retinoic acid as sole ingredient in a pharmaceutical or cosmetic composition comprising administering effective amount of the composition to treat sensitive skin or skin damage induced by UV radiation.

- Photoprotective/cosmetic compositions comprising benzotriazole, bisresorcinyltriazine and benzoazolyl/benzodiazolyl sunscreens

Topically applicable sunscreen/cosmetic compositions well suited for the synergistically enhanced photoprotection of human skin and/or hair against the damaging effects of UV-irradiation, particularly solar ratiation, comprise synergistically UV-photoprotecting effective amounts of each of (a) at least one benzotriazole compound, (b) at least one bisresorcinyltriazine compound and (c) at least one compound containing at least two benzoazolyl groups per molecule and/or at least one compound containing, per molecule, at least one benzodiazolyl group, formulated into a topically applicable, cosmetically acceptable vehicle, diluent or carrier therefor.

- Antiperspirant product and method

An antiperspirant product for the human skin, comprising an antiperspirant active for topical application, and an effective amount of a compound which inhibits the acidification mechanism in the eccrine gland to elevate the pH of sweat.

- Cosmetic compositions

A cosmetic composition, preferably an antiperspirant stick, has a carrier liquid which is almost exclusively silicone oil, structured with lanosterol. Instability is avoided by nearly complete exclusion or complete exclusion of silicon-free organic liquids.

- Aerated composition, process for its manufacture and its use

An aerated composition comprising, in a physiologically acceptable medium, an oily phase dispersed in an aqueous phase, characterized in that it contains air or inert gas in a sufficient amount to have a relative density ranging from 0.2 to 0.8 and in that it comprises at least one amphiphilic polymer and at least one anionic surfactant. The composition exhibits a very fine texture and good cosmetic properties, while remaining very stable over time. In particular, it can constitute a cosmetic composition intended especially for treating and/or cleansing the skin, including the scalp, nails and/or hair and for making up the skin.

- Transfer-resistant cosmetic composition comprising a dispersion of polymer particles in a liquid fatty phase

A composition suitable for topical application, comprising a liquid fatty phase, at least one dye, and at least 2% by weight, relative to the total weight of the composition, of polymer particles which are dispersed and stabilized at the surface by at least one stabilizer in the liquid fatty phase. The present invention also provides a composition suitable for topical application, comprising a cosmetic, dermatological, hygiene or pharmaceutical liquid fatty phase, at least one active agent selected from the group consisting of cosmetic, dermatological, hygiene and pharmaceutical active agents, and at least 2% by weight, relative to the total weight of the composition, of polymer particles which are dispersed and stabilized at the surface by at least one stabilizer in the liquid fatty phase.

- Transfer-free cosmetic composition comprising a dispersion of non-film-forming polymer particles in a partially nonvolatile liquid fatty phase

The present invention relates to a care and/or make-up anhydrous composition, in particular a cosmetic, dermatological, hygienic or pharmaceutical composition, for the skin, which may be provided in the form of a cast product or a gel comprising at least one, in particular pulverulent, coloring matter and a dispersion of non-film-forming polymer particles which are surface-stabilized in a partially nonvolatile liquid fatty phase. Depending on the quantity of polymer and of nonvolatile oil, it is possible to obtain, on the lips or the skin, a nonfatty soft film having remarkable transfer-free properties, while imparting a very high degree of comfort. The invention also relates to the use of this dispersion in such a composition.

- Salicylic acid derivatives and their use in cosmetic or dermatological compositions

The invention relates to novel salicylic acid derivatives and to the use thereof in a cosmetic and/or dermatological composition intended for skincare, in particular to combat the signs of ageing of the skin and/or to improve the radiance of the complexion and/or to smooth out facial and/or body skin and/or to treat wrinkles and fine lines on the skin and/or to stimulate the process of epidermal renewal.

- Use of oxazolidinone derivatives as anti-penetrating agents in a cosmetic and/or dermatological composition

The use of oxazolidinone derivatives in a composition for topical application, especially a cosmetic or dermatological composition, in particular as anti-penetrating agents. These derivatives make it possible especially to prevent the penetration of active agents which are compatible with the skin, the hair and/or mucous membranes, and thus to reduce, or even eliminate altogether, the side effects of these active agents without decreasing their efficacy. Thus, the cosmetic or dermatological compositions containing such active agents make it possible to soften the skin, mucous membranes and the hair.

- Antimicrobial wipes

The present invention relates to an antimicrobial wipe comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active; from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant; from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent; and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0. The invention also encompasses methods for cleansing skin, reducing the number of germs on the skin, and providing residual effectiveness versus Gram positive and Gram negative bacteria using these products.

- Compositions for disinfection of skin and mucous membrane

A process and compositions for disinfecting the skin, hands and mucous membrane. The compositions contain an optical brightener and exhibit intense fluorescence in the visible wavelength range on exposure to UV light and thus permit simple monitoring of the treated skin or mucous membrane surfaces for ensuring complete disinfection, but without exhibiting the disadvantages associated with the use of conventional dyes, such as discoloration of the skin and articles.

- Antiperspirant compositions

Antiperspirant emulsions which exhibit excellent phase stability even in the presence of an effective concentration of antiperspirant salts in solution and which are thickened are obtainable by dispersing a hydratable polymer and particularly an amphoteric or cationic modified starch in an aqueous emulsion forming a viscous emulsion, often at an elevated temperature, subjecting the emulsion to high shear, thereby reducing the droplet size of the dispersed oil phase, bringing the emulsion to below 40.degree. C. and introducing the antiperspirant, preferably in aqueous solution. The viscous emulsion subjected to high shear mixing desirably has a Sheer Stress of 10 to 500 Pa. The resultant emulsions show good phase stability even when they contain aluminium/ zirconium antiperspirant salts that promote instability and even at elevated storage temperatures such as at 50.degree. C.

- Cosmetic composition containing a polysaccharide and an acrylic terpolymer, and use of this composition for the treatment of keratinous material

The present application relates to cosmetic compositions containing, in a cosmetically acceptable aqueous medium, at least one polysaccharide and an acrylic terpolymer, as well as to the use of these compositions for treating the skin or the hair. The acrylic terpolymer comprises: a) about 20 to 70% by weight of a carboxylic acid containing .alpha., .beta.-monoethylenic unsaturation; b) about 20 to 80% by weight of a non-surfactant monomer containing monoethylenic unsaturation, which is different from a), and c) about 0.5 to 60% by weight of a nonionic urethane monomer which is the product of reaction of a monohydric nonionic surfactant with a monoisocyanate containing monoethylenic unsaturation. The polysaccharide is preferably a guar gum.

- Carrier patch for the delivery of agents to the skin

A carrier patch for delivering agents locally to the skin or systemically via the skin. The patch comprises a pad having a lower surface area to which an adhesive is adhered, and a primary agent applied to discrete regions of the patch in a manner to minimize the deleterious effects of the adhesive on the primary agent. The invention further comprises a method for the discrete application of the agent to the patch, and a method of using the patch for the delivery of the agent to the skin.

- Crosslinked water-soluble or water-dispersible polyurethanes

The present invention relates to crosslinked, water-soluble or water-dispersible polyurethanes of A) at least one water-soluble or water-dispersible polyurethane prepolymer having terminal isocyanate groups of a) at least one compound having a molecular weight in the range from 56 to 300 which contains two active hydrogen atoms per molecule, b) at least one polymer containing two active hydrogen atoms per molecule, c) at least one compound which contains two active hydrogen atoms and at least one ionogenic or ionic group per molecule, d) at least one diisocyanate, B) at least one polymer containing groups which are reactive toward isocyanate groups, chosen from hydroxyl, and primary and secondary amino and/or carboxyl groups, or the salts thereof.

- Use of shogaols and gingerols for preparing deodorant compositions

A method is provided for suppressing body odors in a human by administering orally to the human or applying to the skin of the human, at least one compound chosen from the group consisting of shogaols and gingerols. The compound corresponds to the general formula: ##STR1## in which X represents: either --CH.dbd.CH--, in which case n is equal to 1, 2, 4, 6, or 8; --CH.sub.2 --CH(OH)--, in which case n is equal to 2, 4, 6 or 8.

- Hair and skin treatment product

A hair treating and skin care preparation for use alone or as a component in other preparations, for use in hair dyeing, bleaching, hair conditioning or skin treatments comprises a mixture of hydrogen peroxide, a silicon component selected from the group consisting of silica gel, silicic acid anhydride and mixtures thereof, and a relatively small amount of Aloe vera gel. Prior to use, at least 1.5 g of leaf material from an Aloe vera plant per liter of the hydrogen peroxide, silicon component and aloe vera mixture are placed in the mixture for at least 12 hours in order to dissolve active components from the leaf material and then the undissolved remnants are removed. The preparation can be used for treating skin conditions such as a rash or eczema. A similar preparation can also be combined with water and one or more herbs to provide a health providing remedy that is applied to the skin.

- Transdermal application system containing acetylsalicylic acid for antithrombotic therapy and cancer prophylaxis

The invention concerns a transdermal application system for antithrombotic therapy and for the prophylaxis against cancer, respectively, containing as active substance acetylsalicylic acid and/or pharmaceutically acceptable salts thereof.

- Transdermal device for administration through de-epithelialized skin

A transdermal device is described suitable for delivery of a pharmaceutical to the systemic circulation through de-epithelialized skin. In its various embodiments the device includes means to prevent the attack of any protein or polypeptide active agent included therein by proteolytic enzymes which exude from the lesion, means to prevent the ingress of bacteria and other cellular debris from the lesion and means to ensure that substantially all said active agent is directed to the de-epithelialized lesion.

- Skin cleansing composition for removing ink

A skin cleansing composition suitable for removing ink and other stains from the hands and arms of a user includes an effective amount of a low molecular weight alcohol having from one to twelve carbon atoms and an effective amount of a peroxide releasing agent, e.g., a percarbonate salt, preferably sodium percarbonate, such that together, the alcohol and percarbonate salt provide a synergistic reaction that effectively removes ink from the skin of the user. Other additives such as fillers, abrasives, and detergents may be employed to provide further cleansing action.

- Substituted 5-biphenyl-3,4-dihydroxy-2(5H)-furanones and method of use therefor

The present invention broadly relates to racemic or optically active 5-substituted 3,4-dihydroxy-2(5H)-furanone compounds and their pharmaceutically acceptable salts, useful for treating a pathology in which reactive oxygen species and inflammatory mediators are contributing deleterious factors, such as acute or chronic inflammatory disorders, for example, asthma, rheumatoid arthritis, inflammatory bowel disease, and acute respiratory distress syndrome; neurodegenerative disorders, such as Alzheimer disease, Parkinson disease, amyotrophic lateral sclerosis, traumatic brain injury and multiple sclerosis; cardiovascular diseases, such as atherosclerosis; viral diseases, such as AIDS; skin diseases, such as psoriasis, sunburn and premature aging; and eye diseases, such as glaucoma, cataract, senile macular degeneration, inflammatory eye conditions, trauma, post-traumatic eye disorders, diabetic retinopathy, and eye infections.

- Nucleic acid constructs whose activity is affected by inhibitors of cyclin-dependent kinases and uses thereof

The present application discloses nucleic acid constructs comprising nucleic acids which encode a protein which inhibits the cellular protein p27 and thereby relieves the inhibition of the proliferation of the cell which is brought about by p27, fragments and variants thereof, some of which possess a dominant interfering character.

- Mononuclear phagocytes and their use to promote axonal regeneration

Methods and compositions are disclosed for the use of allogeneic mononuclear phagocytes to promote axonal regeneration in the central nervous system of a mammal. In one embodiment, allogeneic mononuclear phagocytes are cultured together with stimulatory tissue, such as skin, dermis or at least one nerve segment, and are subsequently administered into the central nervous system of a mammal at or near a site of injury or disease. In an alternative embodiment, autologous monocytes, preferably stimulated autologous monocytes, are administered into the central nervous system of a mammal at or near a site of injury or disease. CNS administration of mononuclear phagocytes may optionally be combined with administration of an adjuvant factor (e.g. aFGF) to the CNS, anti-inflammatory therapy of the mammal, or both. Methods for screening stimulatory tissue and cells and methods and compositions for cryopreserved allogeneic mononuclear phagocytes are also disclosed.

- Cosmetic/pharmaceutical compositions comprising .beta.-adrenergic agonists/substance P antagonists

Cosmetic/pharmaceutical compositions, well suited for the treatment of a variety of mammalian disorders of, for example, the skin, hair and/or mucous membranes, a manifestation of which is an excess in the synthesis and/or in the release of substance P, e.g., for the treatment of cutaneous disorders and sensitive skin, comprise an effective substance P antagonist amount of at least one .beta.-adrenergic agonist, e.g., salbutamol, in a cosmetically/pharmaceutically acceptable medium therefor.

- Water-in-oil emulsions containing amino acid salts of salicylic acid

A cosmetic composition in the form of a water-in-oil emulsion comprising: (a) continuous oil phase; and (b) discontinuous aqueous phase; and (c) amino acid salt of salicylic acid or salicylic acid derivative. The compositions of the invention provide regulation of the oily and/or shiny appearance of the skin.

- Pharmaceutical, cosmetic composition with base of microbial culture mixed with an essential oil and an acid

The invention concerns a cosmetic or pharmaceutical composition. This composition is characterised in that it contains a microbial culture compatible in cosmetics or in pharmacy or in therapy, in particular a culture of micro-organisms selected among the acetic or lactic bacteria, freeze-dried yeast, suspensions of micro-organisms, fermented organic substances, for example fermented pollen, or an inactivated culture of bacteria of the genus bifidobacterium or of bacteria related to this genus mixed with an essential oil and an acid preferably an organic acid, such as citric acid. This composition has an activity for regenerating the skin, in particular anti-wrinkle properties, for erasing old scars, for repairing burnt tissues, for promoting skin healing, for eliminating pigmentary spots and also for promoting growth or fresh growth of superficial body growth including nails, hair or hairs.

- Topical formulations comprising skin penetration agents and the use thereof

Disclosed are topical pharmaceutical compositions comprising a pharmaceutically active agent such as a corticosteroid, a diol, cetyl alcohol, glyceryl monostearate, laurocapram, stearyl alcohol, sodium lauryl sulfate and water. Also disclosed is a method for the manufacture of the compositions and methods for treating inflammatory skin conditions with the compositions.

- Water-soluble polymers and their use in cosmetic formulations

Water-soluble polymers whose characteristic structural elements comprise units of the formulae I and/or II ##STR1## where R.sup.1 is H, alkyl, cycloalkyl, aryl or aralkyl, R.sup.2 and R.sup.3 independently are as defined for R.sup.1 or are selected from substituted alkyl, substituted cycloalkyl, substituted aryl or substituted aralkyl, the substituents being selected from OH, O-alkyl, O-aryl, SH, S-alkyl, S-aryl, NH.sub.2, NH-alkyl, NH-aryl, N(alkyl).sub.2, possibly in protinated form, N(Alkyl).sub.3.sup.+3 Z.sup.-, where Z is the radical of an inorganic or organic acid, COOH, COO-alkyl, CONH.sub.2, CONH-alkyl, CON(alkyl).sub.2, CN and SO.sub.3 H; and the indices x are each independently an integer from 1 to 20; and the acid addition salts of these polymers, (processes for whose preparation are also described), are used in cosmetic compositions.

- Additive for improving the water resistance of cosmetic or dermatological formulations

A method for imparting water resistance to or improving water resistance of a cosmetic or dermatological formulation, comprising adding an water resistance enhancing effective amount of 1,2-pentanediol to the otherwise conventional cosmetic or dermatological formulation comprising at least one cosmetic and/or dermatological active agent in a cosmetically and/or pharmaceutically acceptable carrier for topical application to the skin of humans.

- Anhydrous antiperspirant compositions containing water-reactive monomers as antiperspirant active

Disclosed are non-adhesive antiperspirant compositions comprising a water or sweat-reactive monomer as the antiperspirant active, an anhydrous carrier, and an optional polymerization inhibitor, wherein the compositions are applied topically to the underarm or other suitable area of the skin to inhibit or prevent perspiration. The applied compositions form a discontinuous polymer-containing antiperspirant active on the applied skin surface, wherein the polymer-containing active is derived from water-reactive monomers that reacts with sweat at the opening of the sweat ducts after application, to thereby polymerize and form the polymer-containing antiperspirant active over and within the affected sweat ducts. The antiperspirant compositions and corresponding methods of application provide alternative antiperspirant active materials and product formulations, and provide improved efficacy and/or application cosmetics.

- Nanoemulsion based on phosphoric acid fatty acid esters and its uses in the cosmetics, dermatological, pharmaceutical, and/or ophthalmological fields

The present invention provides a nanoemulsion, that includes: an oily phase dispersed in an aqueous phase; and at least one anionic surfactant selected from the group including phosphoric acid fatty esters and oxyethylenated derivatives thereof, and mixtures thereof; wherein the oily phase includes oil globules having a number-average size of less than 100 nm; wherein the oily phase includes at least one oil having a molecular weight of greater than 400; and wherein a weight ratio of the oily phase to the surfactant ranges from 2 to 10. The invention also provides a process for making the nanoemulsion, and methods for its use. The nanoemulsion is ideally transparent and stable on storage. It can ideally contain large amounts of oil while retaining good transparency and good cosmetic properties. The nanoemulsion is particularly useful in compositions, including topical, pharmaceutical, dermatological, cosmetic, opthalmic, and opthalmologic. The composition is also particularly useful in applications to the skin, hair, scalp, mucous membranes, and eyes.

- Transdermal delivery system

A transdermal delivery system comprising an active ingredient selected from the group consisting of peptides, proteins and mixtures thereof and a pharmaceutically acceptable oxidizing agent. The transdermal delivery system is an easy-to-use topical system that facilitates the penetration of an active ingredient, such as insulin, through the skin layers and into the blood stream. Additionally, the invention includes a method for treating diabetes and other pathologic systemic conditions comprising administering an active ingredient selected from the group consisting of peptides, proteins and mixtures thereof and a pharmaceutically acceptable oxidizing agent.

- Polyurethanes as topical skin protectants

Polyurethane compositions for the protection of skin from material that is harmful to the skin or substances that are capable of penetrating the skin, are described.

- Cooling compositions with reduced stinging

The present invention provides coolant compositions for topical application to the skin which can provide long-lasting cooling with low or reduced skin sting. The compositions comprise a mixture of specific type of acyclic carboxamide coolant with a specific type of 3-substituted-p-menthane coolant, an aqueous vehicle, and no more than about 30% C.sub.1 -C.sub.6 monohydric alcohol.

- Stable gelled aqueous composition with a high electrolyte content

Compositions suitable for cosmetic and/or dermatological use which contain at least one electrolyte and/or at least one primary alcohol, at least one associative polyurethane, at least one oxyalkylenated polymer, and water.

- Drug delivery device

A drug delivery device includes (a) a substantially moisture vapor permeable, liquid impermeable, flexible thermoplastic backing layer, (b) a moisture vapor permeable, flexible, oleophilic thermoplastic resin foam layer, (c) a pressure sensitive adhesive layer, and (d) a drug reservoir containing at least one hydrophilic drug composition and possessing a moisture vapor permeable, but hydrophilic drug composition impermeable, barrier layer applied to one surface thereof with the drug reservoir being applied to a portion of the adhesive layer such that the barrier layer lies between the hydrophilic drug composition and the adhesive layer thereby preventing any significant migration of the drug composition from the drug reservoir into the adhesive layer.

- Corn extract contraceptive

Novel compositions extracted from corn products provide contraceptive and anti-neoplastic activities. Using novel extraction procedures, compositions may be isolated from corn products. For example, a Zea mays plant product is extracted in a first solvent to produce a solvent extract, the solvent extract is dried to produce an extracted solid, the extracted solid is solubilized in a second solvent, the solubilized extract is purified in a chromatographic process, and an active fraction is collected from the chromatographic process. Compositions may be applied to animal bedding or food, and are adaptable to any suitable method of administration. The contraceptive activity of these compositions is effective for both males and females.

- Quinoline derivatives

A compound, or a solvate or a salt thereof, of formula (I), wherein, Ar is an optionally substituted aryl or a C.sub.5-7 cycloalkdienyl group, or an optionally substituted single or fused ring aromatic heterocyclic group; R, R.sub.1, R.sub.2 and R.sub.3 are as defined in the description; a process for the preparation of such a compound, a pharmaceutical composition containing such a compound or composition in medicine. ##STR1##

- Enhanced skin penetration system for improved topical delivery of drugs

The invention relates to pharmaceutical compositions for topical application comprising a safe and effective amount of a pharmaceutical active, and from about 0.1% to about 10.0% of a high molecular weight cationic polymer. These compositions provide enhanced penetration of the pharmaceutical active.

- Dry emollient compositions

The present invention are dry-feel emollient compositions comprising jojoba oil based esters that have use in personal care, cosmetic, cosmaceutical and pharmaceutical products. These compositions are essentially solid at room temperature, can be provided in various shapes and sizes (especially as particulates such as spheres), and can be produced from combinations of fatty alcohols, isopropyl esters and wax esters obtained from the oil contained in the seed of the jojoba plant. These new compositions also increase the range of applications for cosmetic compositions through an emollient that is more polar and hydrophilic than is found in jojoba oils. The compositions of the present invention may be obtained by a novel process of a base catalyzed alcoholysis reaction between jojoba oil and an alcohol, such as isopropyl alcohol. These components, whether exclusively jojoba esters or when combined with other carrier and vehicle components (including other emollients or binders) can form excellent carrier composition for use in the cosmetic, personal care and/or pharmaceutical field. Typical materials with which the compositions of the present invention may be blended include, but are not limited to, cosmetic oils and waxes, both natural and synthetic, (including hydrogenated or partially hydrogenated oils), silicone oils, mineral oils, long chain esters, vitamins, long chain fatty acids, cosmeceuticals, pigments, botanical extracts, esters and ethers, dimers, trimers, oligomers, and polymers, and the like. The proportions of the jojoba esters should be chosen to provide the dry-feel to the composition, which is highly desired. This will usually require a weight percent that ranges from 10% to 100% by weight of carrier material in the composition.

- Cosmetic or dermatological composition contacting at least one natural or recombinant spider silk or an analog

A cosmetic or dermatological composition containing, as an active substance, at least one natural or recombinant spider silk protein, or an analog of such a protein. The composition may be in the form of hair products, skincare products, make-up products or antisun products.

- Solid cosmetic composition and uses thereof

A solid composition for topical application comprising, in an aqueous phase, a gelling system comprising (i) gellan gum, (ii) at least one other hydrocolloid chosen from the group formed by xanthan gum, carboxymethylcellulose, hydroxypropylcellulose, methylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, agar-agar, carrageenans, alginates, carob gum, guar gum, gum arabic, karaya gum, gum tragacanth, ghatti gum, pectins, gelatin, caseinates and hydroxypropylguar, and (iii) at least one amphiphilic polymer comprising at least one fatty chain and at least one hydrophilic unit.

- Water containing wax-based product

The present invention relates to a wax-based composition comprising at least about 0.5-30% water in a water-in-oil emulsion, wherein water is encapsulated in a lamellar lipid vesicle capable of withstanding wax melting point temperatures. The composition is useful in delivering water soluble actives in an anhydrous base, and is particularly well-adapted for uses in lipsticks and lip-care products.

- Antiwrinkle composition comprising a combination of tightening polymers of synthetic and/or natural origin and of dendritic polyesters

The present invention relates to an antiwrinkle composition that includes, in a physiologically acceptable medium: a dispersion of a film-forming polymeric system containing at least one polymer capable of forming a film permeable to water vapor, having a Young's modulus ranging from 10.sup.8 to 10.sup.10 N/m.sup.2 and producing, after application at a concentration of 7% in water and then drying, a retraction of the isolated stratum corneum greater than 1% at a temperature of 30.degree. C. and a relative humidity of 40%, and a dendritic polyester polymer having terminal hydroxyl functional groups.

- Topical delivery systems for active agents

This invention relates to a method for enhancing the transmembrane penetration of benefit agents using a certain non-ionic lipid/surfactant-containing formulation as an enhancing agent, and the compositions used therein. Various active agents, such as anti-dandruff agents, hair growth agents, hair inhibitor agents, anti-acne agents, anti-aging agents, depilatory agents, and depigmentation agents, may be effectively delivered into the skin, hair follicles and sebaceous glands using the compositions of the present invention.

- Antimicrobial wipes which provide improved residual benefit versus Gram positive bacteria

The present invention relates to an antimicrobial wipe comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active; from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant; from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent; and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0; wherein the antimicrobial cleansing composition has a Gram Positive Residual Effectiveness Index of greater than about 0.5; and wherein the antimicrobial cleansing composition has a Mildness Index of less than about 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram positive bacteria using these products.

- Cosmetic composition comprising particles of melamine-formaldehyde or urea-formaldehyde resin and its uses

Cosmetic composition comprising particles of melamine-formaldehyde or urea-formaldehyde resin and its uses. The present application relates to a composition comprising, in a physiologically acceptable medium, at least one oily phase and particles of melamine-formaldehyde or urea-formaldehyde resin, to the use of the said composition, especially as a cosmetic composition for caring for and/or making up the skin, in particular for softening defects of the relief of the skin, such as microrelief features, wrinkles or pores, while conferring a natural appearance on the skin, and to its use in treating greasy skin. The particles advantageously have a number-average size ranging from approximately 0.1 to 20 .mu.m. The composition of the invention can be anhydrous or can be provided in the form of a water-in-oil or oil-in-water emulsion. The invention also relates to the use of particles of melamine-formaldehyde or urea-formaldehyde resin as mattifying agent in a cosmetic composition.

- Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue

Individuals in need of treatment of ischemia-related reperfusion are treated, preferably intravenously, with a composition which includes a compound which binds to a receptor for the glucagon-like peptide-1. The invention relates to both the method and compositions for such treatment.

- Methods for regulating the condition of mammalian keratinous tissue

The present invention relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of a composition comprising: a) a safe and effective amount of farnesol; and b) a dermatologically-acceptable carrier for the farnesol. In additional embodiments, the above composition is suitable for thickening skin and preventing and/or retarding atrophy of mammalian skin, preventing and/or retarding the appearance of spider vessels and/or red blotchiness on mammalian skin, preventing and/or retarding the appearance of dark circles under the eye of a mammal, preventing and/or retarding sallowness of mammalian skin, preventing and/or retarding sagging of mammalian skin, softening and/or smoothing lips, hair and nails of a mammal, and preventing and/or relieving itch of mammalian skin.

- Production of metal lumps and apparatus therefor

Metal lumps or pebbles are produced by introducing a molten metal stream into a stream of water in a direction which is substantially the same as the direction of the water stream and at a velocity which is substantially the same or slightly less than the velocity of the water stream.

- Antiperspirant compositions

A cosmetic composition preferably an antiperspirant composition, in solid or soft-solid form has a continuous phase which contains a water-immiscible liquid carrier and also contains a structurant which is partially or fully esterified cellobiose of the formula ##STR1## wherein each Z is independently hydrogen or an acyl group of the formula ##STR2## where R denotes a hydrocarbyl group containing from 4 to 22 carbon atoms. Not more than half of the Z groups are hydrogen.

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US: 6287548

- Treatment of acne, seborrheic dermatitis and other skin diseases with salt solution containing NACL

The present invention provides a composition of matter which has been demonstrated to be a very effective treatment for acne, seborrheic dermatitis and related skin diseases when applied to and contacted with affected skin areas, while avoiding the disadvantages and complications attendant to more established treatments. The composition comprises a synthetic mixture of salts which, when dissolved in a solvent such as water, is ionically composed primarily of a mixture of sodium and magnesium cations and chloride and sulfate anions, and which is preferably free of added zinc. More specifically, the salt mixture according to the present invention comprises the following range of composition in grams/kilogram of salt mixture in the ionic state, the balance being water of hydration:

- Cosmetic or dermatological topical compositions comprising dendritic polyesters

The present invention relates to cosmetic or dermatological compositions capable of being applied to the skin, the keratinous fibers, the nails, the semimucous membranes and/or the mucous membranes, and which includes a dendritic polyester polymer having terminal hydroxyl functional groups or the combination of such a polymer with a film-forming polymer. It also relates to methods of cosmetic or dermatological treatment using these compositions as well as the use of the compositions for the preparation of dermatological or cosmetic compositions.

- Leave-on antimicrobial compositions which provide improved residual benefit versus gram positive bacteria

The present invention relates to a leave-on antimicrobial composition comprising from about 0.001% to about 5% of an antimicrobial active; from about 0.05% to about 10% of an anionic surfactant; from about 0.1% to about 10% of a proton donating agent; and from about 0% to about 99.85% of water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0; wherein the leave-on antimicrobial composition has a Gram Positive Residual Effectiveness Index of greater than about 0.5; and wherein the leave-on antimicrobial composition has a Mildness Index of greater than 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram positive bacteria using these products.

- Low-pH, acid-containing personal care compositions which exhibit reduced sting

The preset invention relates to personal care compositions comprising from about 0.5% to about 80% of a surfactant, from about 0.1% to about 12% of a polymeric acid; and from about 3% to about 98.899% of water, wherein the composition is adjusted to a pH of from about 3.0 to about 6.0.

- Treatment of oncologic tumors with an injectable formulation of a Golgi apparatus disturbing agent

Novel pharmaceutical formulations for treating a cellular proliferative disease are provided comprising: a therapeutically effective amount of a Golgi apparatus disturbing agent; a biocompatible carrier; and a solvent. In preferred formulations, the Golgi apparatus disturbing agent is brefeldin A (BFA) and the biocompatible carrier is a polymer such as chitin or chitosan. Methods of treating cellular proliferative diseases using the pharmaceutical formulations are also described.

- Sunscreen compositions

The present invention relates to compositions suitable for use as sunscreens which comprise a UVA sunscreen active and a carrier suitable for application to the skin. These compositions are substantially free of benzylidene camphor derivatives and provide excellent stability, efficiency, and UV protection efficacy in a safe, economical and aesthetically appealing manner. The compositions have a Sunscreen Efficiency Index of at least about 1.75, a UVA Efficacy Value of at least about 0.5, a UVA Photostability Index of at least about 0.85, a UVB Photostability Index of at least about 0.85, and a Transparency Value of less than about 10. Methods of using the compositions are also disclosed.

- Powder to liquid compositions

The invention relates to cosmetic or pharmaceutical powder-to-liquid compositions comprising hydrophobically coated silica particles into which are incorporated water and a water soluble polymer, the composition containing substantially no oil.

- Derivatives of arabinogalactan and compositions including the same

Derivatized Arabinogalactan can be utilized in a variety of compositions to impart functionality without imparting negative rheological affects when the amount of the derivatized Arabinogalactan is increased in the composition. This is particularly important in the personal care industry, where it is desirable to have the flexibility to adjust the amount of derivatized Arabinogalactan depending upon the results it is desired to deliver to the user without negatively impacting the overall viscosity of the personal care composition.

- Compositions containing mimosa phenolic compounds

The invention relates to topical cosmetic and pharmaceutical composition for enhancing collagen levels in skin cells, the compositions comprising an effective amount of a biologically active phenolic compound-containing extract, or active fraction thereof, obtainable from Mimosa pudica.

- Compounds of the benzylaminodiacetamide family, compositions comprising them, preparation process and uses

The present application relates to novel compounds belonging to the benzylaminodiacetamide family which have good anti-irritant and soothing properties. The invention also relates to their use in a composition comprising a physiologically acceptable medium, in particular in order to prevent and/or treat certain cutaneous disorders and more particularly in order to treat sensitive skins.

- Cosmetic composition containing an anionic polymer and an acrylic terpolymer, and use of this composition for the treatment of keratinous material

The present application relates to cosmetic compositions containing, in a cosmetically acceptable aqueous medium, at least one anionic polymer and an acrylic terpolymer, as well as to the use of these compositions for treating keratinous material. The acrylic terpolymer comprises: a) about 20 to 70% by weight of a carboxylic acid containing .alpha.,.beta.-monoethylenic unsaturation; b) about 20 to 80% by weight of a non-surfactant monomer containing monoethylenic unsaturation, which is different from a), and c) about 0.5 to 60% by weight of a nonionic urethane monomer which is the product of reaction of a monohydric nonionic surfactant with a monoisocyanate containing monoethylenic unsaturation. The invention relates in particular to leave-in hair products, such as gels, mousses, lacquers and sun compositions.

- Cosmetic and/or dermatological powder, process for its preparation and its uses

A cosmetic or dermatological powder, which comprises (i) from 5 to 60% by weight, relative to the total weight of the powder, of at least one starch modified by pregelatinization, oxidation, crosslinking, esterification or a combination thereof, (ii) from 30 to 90% by weight, relative to the total weight of the powder, of an oily phase comprising at least one oil, and (iii) at least one electrolyte, wherein the oily phase/starch weight ratio is .gtoreq.1.

- Oxindolylquinazoline derivatives as angiogenesis inhibitors

The invention relates to compounds of formula (I) ##STR1## and salts thereof as further defined herein, wherein ring Z is a 6-membered heterocyclic ring containing 1 to 3 nitrogen atoms, and the use of such compounds and salts to inhibit the effects of VEGF and FGF, and in the treatment of a number of disease states including cancer and rheumatoid arthritis.

- Photoprotective/cosmetic compositions comprising bis-hydroxyphenylbenzotriazole and benzazolyl/benzodiazolyl sunscreens

Topically applicable sunscreen/cosmetic compositions well suited for the SPF synergistically enhanced photoprotection of human skin and/or hair against the damaging effects of UV-irradiation, particularly solar radiation, comprise synergistically UV-photoprotecting effective amounts of each of (a) at least one bis-hydroxyphenylbenzotriazole sunscreen compound and (b) at least one second sunscreen compound which comprises at least two benzazolyl functional groups per molecule and/or at least one sunscreen compound which comprises at least one benzodiazolyl functional group per molecule, formulated into a topically applicable, cosmetically acceptable vehicle, diluent or carrier therefor, advantageously formulated as an oil-in-water emulsion.

- Cosmetic composition comprising an aqueous dispersion of film-forming polymer particles containing 1,2-pentanediol

The invention relates to the use in a cosmetic or dermatological composition which can be applied to the skin, keratin fibres, semi-mucous membranes and/or mucous membranes, of an aqueous dispersion of film-forming polymer particles combined with an antimicrobial protection system, in particular an antibacterial and/or antifungal system, comprising 1,2-pentanediol. The invention relates in particular to a make-up composition for the lips or the body.

- Synergistic composition comprising a compound of lipoamino acid structure and a water lily extract

Composition characterized in that it comprises, as active principle, at least one compound of formula (I): ##STR1## its topically acceptable salts, which R represents the characterizing chain of a saturated or unsaturated, linear or branched fatty acid containing from 3 to 30 carbon atoms, R.sub.1 represents the characterizing chain of an amino acid and m is between 1 and 5, and the constituents of at least one extract and/or of at least one tincture from plants of the Nympheacea family. The composition is useful in cosmetics.

- Treatment of skin damage using conjugated linoleic acid and ascorbyl fatty acid esters

A synergistic combination of conjugated linoleic acid and fatty acid esters of ascorbic acid is topically applied to treat skin damage, such as contact dermatitis, atopic dermatitis, xerosis, eczema, rosacea, seborrhea, psoriasis, thermal and radiation burns, other types of skin inflammation, and aging. Typical compositions contain from about 1% to about 25% by weight of a CLA preparation containing 9,11-octadecadienoic acid and 10,12-octadecadienoic acid, and from about 0.5% to about 15% by weight of a saturated fatty acid ester of ascorbic acid such as ascorbyl palmitate.

- Device for applying a film-forming composition

A device for forming a peel-off film in situ includes a film-forming composition, a receptacle containing the composition, an applicator including an applicator element, and a wiper member inside the receptacle. The applicator element and the wiper member are organized in such a manner that, after wiping, and on being moved in contact with the skin, the applicator element leaves a film of film-forming composition which, once dry, can be peeled off and has a density per unit mass that preferably lies in the range 1 mg/cm.sup.2 to 15 mg/cm.sup.2. The film-forming composition preferably includes at least one active substance for cosmetic and/or pharmaceutical treatment of the skin.

- Solid warming pulverulent composition to be hydrated for caring for or cleaning the skin

A warming and foaming anhydrous pulverulent composition, which is capable of being, hydrated, which comprises cosmetically acceptable powder and a binder, where the powder comprises solid particles of expanded polymers and the binder comprises an effective amount of an agent capable of giving off heat during hydration. The composition may be used, for example, for cleaning and/or caring for human skin.

- Body cleansing agent

The invention relates to lipid soluble, water insoluble cosmetic or dermatological active substances which can be included in body cleansing agents in the form of an aqueous preparation with at least 5 wt. % water soluble ionic or non-ionic surfactant content by solubilization of the active substances with a polar lipid in lipid-surfactant mixed micelles or liquid crystals or by microemulsification with a nonpolar lipid, wherein the emulsion particles have a diameter which is less than 500 nm. Said agents are also characterized by enhanced skin penetration by the active substances.

- Dietary product effective to combat oxidative stress and cell decay

The present invention relates to a dietary product comprising ubiquinone, stabilized vitamin E, phospholipids, selenuim in an organic form and L-methionin, which is effective to combat cell oxidative stress even to the extreme consequences thereof, for example cell decay, acquired and/or congenital immunodeficiency or other alterations in the immune system. The dietary product object of the present invention is also effective as a coadjutant in the treatment of apoptosis, in mutagenesis and/or carcinogenesis, in infectious diseases of viral or bacterial origin or those deriving from other external pathogens, in myelinic and skin diseases, in cardiovascular diseases and in allergies.

- Transdermally administrable medicament with ACE inhibitors

The invention relates to a transdermal system containing at least one angiotensin-converting enzyme inhibitor.

- Proton pump inhibitor in therapeutic combination with antibacterial substances

The invention relates to the use of proton pump inhibitors as combination therapeutics in the treatment of bacterial diseases which do not affect the gastrointestinal track using antibacterially active compounds.

- Use of arbutin monoesters as depigmenting agents

Arbutin monoesters are employed in a composition for topical application, as a depigmenting and/or bleaching agent for human skin, hair and/or head hair. The invention relates to a method of manufacturing a composition of at least one arbutin monoester in a physiologically acceptable medium for depigmenting and/or bleaching human skin, hair and/or head hair.

- Cosmetic composition comprising an aqueous dispersion of film-forming polymer and an aqueous suspension of organopolysiloxane

The invention relates to a composition to be applied to the skin and superficial body growths, comprising an aqueous dispersion of particles of film-forming polymer and an aqueous suspension of particles of at least partially crosslinked solid elastomeric polyorganosiloxane. The invention also relates to a process for caring for or making up keratin substances, which comprises applying the composition to the keratin substances. The composition makes it possible to obtain a film which has good staying power, is water-resistant and feels comfortable.

- Apparatus for heating to a desired temperature for improved administration of pharmaceutically active compounds

Methods and apparatus for improving administration of drugs through the use of heat and other physical means. The present invention relates to the use of heat and other physical means in conjunction with specially designed dermal drug delivery systems, conventional commercial dermal drug delivery systems, or drugs delivered into a sub-skin depot site via injection and other methods to alter, mainly increase, the drug release rate from the dermal drug delivery systems or the depot sites to accommodate certain clinical needs.

- Cosmetic and skin protective compositions

A hair and scalp formulation based on a peroxidase enzyme and synergistic yeast extract therefore. It entails a chemically-inert carrier material, a germicidal/preservative agent, and a metal chelating agent. A skin protective formulation based on peroxidase enzyme and yeast extract. It entails a polymer carrier, a fatty acid emollient, a co-emulsifier of an amino acid complex essential to a fatty acid; an emulsifying agent; a skin healing agent, and a germicidal surfactant. An aqueous formulation adapted for topical hair rinsing consisting of a peroxidase enzyme, a yeast extract adapted to enhance the activity of the enzyme and a cationic hair conditioning agent selected from water-soluble thickening resins.

- Photostabilized sunscreen compositions comprising dibenzoylmethane compounds and benzylidenecamphor-substituted silanes/organosiloxanes

Improvedly photostable, topically applicable cosmetic/dermatological sunscreen compositions well suited for enhanced photoprotection of human skin and/or hair against the damaging effects of UV-A and UV-B irradiation, particularly solar radiation, comprise (i) a photoprotecting effective amount of at least one dibenzoylmethane UV-screening compound, and (ii) an amount of at least one silane or organosiloxane substituted by a benzylidenecamphor functional group effective to photostabilize said at least one dibenzoylmethane UV-screening compound (i).

- Anti-fungal formulation active against a broad spectrum of dermatophytoses

The invention provides a novel anti-fungal formulation active against a broad spectrum of dermatophytoses, said formulation comprising at least about 1% by weight of oil extracted from Rabdosia melissoides and one or more vegetable oils, solvents and additives.

- Solid cosmetic composition free of fillers, containing low amounts of gelling agents

The present invention relates to a solid composition for topical application, which is free of fillers, containing, in an aqueous phase, less than 20% of the total weight of the composition of a hydrophillic gelling system having the combination of at least 2% by weight of kappa-carrageenan, relative to the total weight of the composition, and at least one hydrocolloid chosen from xanthan gum and cellulose derivatives which are soluble in hot water.

- Compressed lecithin preparations

The present invention relates to compositions primarily comprised of phospholipids, commercially known as lecithin, wherein the phospholipids form a solid mass--a liquid crystal phospholipid (LCP)--without the use of emulsifiers or other ingredients which are typically used as carriers for phospholipids. The invention also relates to the methods for making the phospholipid compositions. More particularly, the invention relates to a physical form of phospholipids and its use as a topical cosmetic skin bar, as a nutrient supplement or as a pharmaceutical dosage form if taken orally. Regardless of the exact shape of the new phospholipid composition, it comprises an amount of phospholipid equal to at least about 20% by weight of the total product. The new composition of the phospholipids appears as a solid which is produced by subjecting granular or powdered phospholipids to high levels of pressure which result in the formation of the solid phospholipid composition.

- End modified thermal responsive hydrogels

A pharmaceutic composition includes a pharmaceutically acceptable carrier, comprising a reverse thermally viscosifying polymer. The polymer includes a linear block copolymer, wherein at least one block comprises a poloxamer; and at least one block comprises a biocompatible polymer or oligomer, in an aqueous medium. The composition also includes an active agent which imparts a pharmaceutic or cosmetic effect. The composition viscosities in response to an environmental stimulus. The composition is suitable for administration of the pharmaceutical agent across dermal, otic, rectal, vaginal, ophthalmic, esophageal and nasal mucosal membranes.

- Extensible mask including an adhesive matrix that can be stretched at least in the wet state

The invention relates to a mask for the face or the body, which mask comprises a backing sheet coated on one of its faces with an adhesive matrix containing a permanent adhesive that adheres both to dry skin and to wet skin, at least one of the backing sheet and the adhesive matrix containing at least one active ingredient serving to exert a specific action on the skin. The adhesive matrix is stretchable at least in the wet state, in order to enable the mask to be adapted to fit the shape of the face or of the portion of the body to be treated, the backing sheet being chosen to be capable, at least in the wet state, of stretching so as to accompany the deformations in the adhesive matrix.

- Agar gel bead composition and method

Crushable gel beads 10 formed of an agar complex provide novel cosmetic, pharmaceutical, etc. delivery vehicles for topical delivery of biologically or cosmetically active agents. Preferred agar beads 10 are complexes of a continuous phase of agar gel 12 in a self-supporting solid or semi-solid form with a restraining polymer 14. Entrapped in and dispersed randomly throughout each agar bead 10 is a water-soluble, preferably polar, restraining polymer 14, preferably a quaternized cationic polymer, such as polyquaternium 24 or steardimonium hydroxyethylcellulose. Various active agents 16 may be bound to restraining polymer 14, for example ascorbic acid, lactic acid or papain. Methods of manufacture are also described.

- Anhydrous cosmetic composition containing a fatty phase and pro-liposomes

An anhydrous cosmetic makeup composition contains in addition to a fatty phase formed from oils, fatty bodies and surfactants, and optionally waxes, a vesicular lipidic phase that contains at least one ionic or nonionic amphiphilic lipid and optionally additives. The anhydrous composition also preferably contains at least one cosmetically and/or dermopharmaceutically active material. In the presence of an aqueous phase these compositions release vesicles of the vesicular lipidic phase and potentialize the activity of the cosmetically and/or dermopharmaceutically active material of the composition.

- Cosmetic and/or dermatological composition with a hydrophilic carrier and vitamin C which can be mixed immediately before use

A topical composition separately containing a hydrophilic carrier and a solid which are intended to be mixed immediately before use, the solid being powdered ascorbic acid and the carrier containing an aqueous medium and at least one hydrophilic gelling agent, the carrier being capable of withstanding the introduction of an acidic compound. In a preferred embodiment, the carrier (L) is packaged in a container (1) closed with a cap (3,6) containing ascorbic acid (P), a perforable and/or detachable separator (5) being provided between the acid and the carrier.

- Film forming composition for spraying on the skin

A composition is intended to form on the skin, by spraying from an erasol can, a film for the transdermal administration of an active agent, and the composition contains 0.01-10% by weight of lipophilic vitamins, hormones, nicotine, corticoids, retinoids, antimycosic agents, anistetics, anolgesics, or anti cancer agents for the skin, 0.5 to 25% by weight of an adhesive polysiloxane composition, 5 to 25% by weight of an absorption promoter, 25 to 95% by weight of a volatile solvent containing at least a volatile silicone, and 0.5 to 50% by weight of pressurized propellant gas, and the composition is substantially free from water.

- Cosmetic composition comprising a styrene/acrylate copolymer and a fatty phase

A composition for topical application comprising, in a cosmetically, dermatologically, hygienically or pharmaceutically acceptable support, at least one fatty phase and at least one lipophilic polymer, wherein the lipophilic polymer is a tert-butylstyrene/C.sub.1 -C.sub.10 alkyl methacrylate/C.sub.1 -C.sub.10 alkyl acrylate copolymer. The composition makes it possible to obtain a film which has very good staying power and good transfer-resistance properties. The film obtained is particularly resistant to water, to rubbing, for example with the fingers or against clothing, to perspiration and to sebum.

- Transfer-resistant make-up or care composition based on isoparaffins and functionalized synthetic waxes

A solid transfer-resistant make-up or care composition containing, in a physiologically acceptable medium: at least one volatile hydrocarbon based oil, and as a hardening agent, at least one functionalized synthetic wax having at least one hydroxyl or carboxyl functional group and having a melting point of between 75.degree. C. and 120.degree. C. and Hansen Solubility Parameters, .delta..sub.d, .delta..sub.h such that: wherein

- Cosmetic composition in the form of an emulsion comprising a dispersion of surface-stabilized polymer particles in a liquid fatty phase

A composition for topical application, comprising a liquid fatty phase and an aqueous phase, one of the phases being dispersed in the other phase, and said liquid fatty phase comprising surface-stabilized polymer particles in an amount sufficient to confer transfer-free properties to the composition.

- Use of oxamate derivatives as depigmenting agents

The invention relates to the use of oxamate derivatives in a composition, as agents for depigmenting and/or bleaching human skin, head hair and/or other hairs. The invention also relates to a process for depigmenting and/or bleaching the skin, head hair and/or other hairs, which includes applying a composition comprising oxamate derivatives to human skin, head hair and/or other hairs.

- Microprocessors for use in a device for predicting physiological values

The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.

- Use of a silicone gum to stabilize ascorbic acid, and novel compositions comprising these components

The present invention relates to the use of a silicone gum to stabilize ascorbic acid or one of its esters or salts in a topical composition and to novel compositions comprising these components and having a pH of from 4 to 7. These compositions can be used in the fields of cosmetology, dermatology and veterinary medicine.

- Water-in-oil cosmetic compositions comprising willow bark extract

Cosmetic compositions for topical application to the skin are in the form of a water-in-oil emulsion and comprise (a) continuous oil phase comprising a mixture of volatile silicone and non-volatile silicone; (b) discontinuous aqueous phase; and (c) willow bark extract.

- Composition in the form of a water-in-oil emulsion having a changing shear rate

A cosmetic or dermatological composition, comprising: an aqueous phase dispersed in an oily phase with a silicone emulsifying agent, wherein the viscosity of the composition, measured with a Rheomat 180 viscometer at a shear rate of 200 s.sup.-1 and at 25.degree. C., ranges from 3 Pa.s (30 poises) to 20 Pa.s (200 poises), the aqueous phase constituting at least 78% by weight with respect to the total weight of the composition with the water of the aqueous phase constituting at least 65% of the total weight of the composition, and the emulsifying agent consisting of the dimethicone copolyol of formula (I): wherein R.sup.1 is ##STR1##

- O/W emulsion with a high electrolyte content and its use in dermocosmetics, in particular for treating irritation and/or sensitive skin phenomena

A composition in the form of an O/W emulsion comprising at least 2% by weight, relative to the total weight of the composition, of at least one water-soluble metal salt, and from 2-4.5% by weight, relative to the total weight of the composition, of a suitable emulsifying system, excluding compositions comprising 1% by weight of a gelling agent consisting of a combination of a polyacrylamide, C.sub.13 -C.sub.14 isoparaffin and laureth-7 (CTFA).

- Retinyl carbonate derivatives, preparation process and uses

The present invention relates to novel retinol derivatives having the formula (I): ##STR1## and to processes for preparing them. The invention also relates to the use of these compounds in or for the preparation of compositions intended for treating conditions of the skin or scalp, for example in preventing or combating acne and/or chronological or actinic ageing of the skin.

- Use of an indigoid compound in a cosmetic composition, in particular a make-up composition, in order to confer on it antimicrobial properties and the property of lengthy hold over time

The invention relates to the use of at least one compound of formula: ##STR1## in which R.sub.1 and R'.sub.1 are C.sub.1 -C.sub.18 alkyl radicals which are optionally substituted by one or more halogens or hydroxyls and/or are interrupted by one or more heteroatoms, and R.sub.2 to R.sub.5 and R'.sub.2 to R'.sub.5 are hydrogen or halogen atoms, hydroxyl radicals or C.sub.1 -C.sub.6 alkyl, alkyloxy, acyl or acyloxy radicals, in a cosmetic composition, in particular a make-up composition, in order to confer on it antimicrobial properties and properties of lengthy hold over time and/or of non-migration and/or of freedom from transfer and/or of non-formation of streaks. The invention also relates to a cosmetic composition, in particular a make-up composition and especially an eyeshadow, comprising such a compound in a silicone binder.

- Composition for treating and/or ameliorating the diseases of dandruff, seborrheic dermatitis, psoriasis and eczema and symptoms thereof

A composition that is useful for treating and/or ameliorating the diseases of dandruff, seborrheic dermatitis, psoriasis, and eczema and/or the symptoms associated therewith, and is non-stinging to the eyes is disclosed. The composition contains from about 0.5 weight percent to about 16 weight percent of at least one amphoteric surfactant; from about 1 weight percent to about 10 weight percent of at least one anionic surfactant; from about 0.1 weight percent to about 10 weight percent of at least one non-ionic surfactant; and from about 0.1 percent to about 15 percent active ingredient selected from Undecylenamidopropylbetaine, Undecylenic Acid, and mixtures thereof. A method for treating and/or ameliorating the diseases of dandruff, seborrheic dermatitis, psoriasis, and eczema and/or the symptoms associated therewith including topically applying an effective amount of the composition to the area desired is also disclosed.

- Use of a substance P antagonist in a cosmetic composition, and the composition thus obtained

A substance P antagonist is used in a cosmetic composition to treat sensitive skin. More specifically, a cosmetic composition containing a substance P antagonist is used to prevent and/or combat skin irritations, desquamation, erythermas, sensations of dysesthesia/overheating, or pruritus of the skin.

- Topical, non-cytotoxic, antimicrobial hydrogel with thixotropic properties

A thixotropic, non-cytotoxic, topical hydrogel that contains a proven safe and effective, broad spectrum, antimicrobial agent based on a unique electrolytically derived sodium hypochlorite solution.

- Nanoemulsion based on oxyethylenated or non-oxyethylenated sorbitan fatty esters, and its uses in the cosmetics, dermatological and/or ophthalmological fields

The present invention relates to a nanoemulsion, the oil globules of which have an average size of less than 100 nm, comprising (1) a surfactant which is solid at a temperature of less than or equal to 45.degree. C., which surfactant is chosen from sorbitan fatty esters and oxyethylenated sorbitan fatty esters, (2) at least one oil having a molecular weight of greater than 400 and (3) at least one ionic amphiphilic lipid chosen from the group formed by the alkaline salts of dicetyl and dimyristyl phosphate, the alkaline salts of cholesterol sulphate, the alkaline salts of cholesterol phosphate, lipoamino acids, the sodium salts of phosphatidic acid, cationic amphiphilic lipids and alkylsulfonic derivatives, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The surfactant used is, for example, chosen from sorbitan monostearate, sorbitan monopalmitate and sorbitan 20 EO tristearate. The emulsion obtained is transparent and stable on storage. It can comprise large amounts of oil while retaining good transparency and while having good cosmetic properties. The invention also relates to the use of the nanoemulsion according to the invention in the cosmetics and dermatological fields, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and in the ophthalmological field, as an eye lotion for treating the eyes.

- Water-in-oil emulsion and use thereof in a cosmetic composition

The present invention relates to a water-in-oil emulsion, in particular a cosmetic emulsion, comprising (i) an alkylpolyglycoside having an HLB of less than 7, and (ii) at least one volatile oil. The alkyl chain of the alkylpolyglycoside preferably contains from 14 to 24 carbon atoms and can be in particular an unsaturated linear chain and/or a branched chain, and more particularly an oleyl or isostearyl chain. The volatile oil can be chosen in particular from branched-chain hydrocarbon-based oils and volatile silicone oils, and mixtures thereof. The emulsion obtained is stable and feels fresh when applied. It can be used in particular for caring for the skin, the nails and the hair, for removing make-up from and/or for cleansing the skin, and/or for making up the skin.

- Prolamine-plant polar lipid composition, its method of preparation and applications thereof

Prolamine-plant polar lipid compositions are provided, said compositions including a mixture of a prolamine, a plant polar lipid, at least one polyalcohol in a hydro-alcoholic solution, and an active agent, wherein the composition forms a substantially homogeneous dispersion with skin adhesive properties; wherein the dispersion forms a film and wherein the film contains a gradient of concentrations of the active agent.

- Electrosurgical system

An electrosurgical system comprises a radio frequency generator (1), an electrosurgical instrument (E1), and a fluid enclosure (42). The generator (1) has a radio frequency output for delivery of power to the electrosurgical instrument (E1) when immersed in an electrically-conductive fluid. The electrosurgical instrument (E1) has an electrode assembly (32) at the distal end thereof, the electrode assembly comprising a tissue treatment electrode (34), and a return electrode (38) axially spaced therefrom in such a manner as to define, in use, a conductive fluid path that completes an electrical circuit between the tissue treatment electrode and the return electrode. The fluid enclosure (42) is adapted to surround an operation site on the skin of a patient or an incision leading to a cavity surgically created within the patient's body. The fluid enclosure (42) includes sealing means (44) for sealing against the patient's tissue, and the fluid enclosure includes at least one port (50a, 52a) through which the electrosurgical (E1) is insertable, and through which the electrically-conductive fluid can enter and/or leave the enclosure.

- Disposable thermal body wrap

The thermal body wraps of the present invention comprise a unified laminate structure having at least one continuous layer of a flexible material having a substantially rectangular, dog bone-like shape and having a first side, a second side, a first end, a second end, a plurality of heat cells, and means for releasably attaching the thermal body wrap to a user's body. Preferably the heat cells are placed into positions fixed within or to the unified structure of the thermal body wraps, relative to each other and sufficiently close to provide controlled, sustained, and uniform heat to the body or body part of the user.

- Cosmetic and/or dermatological composition based on ascorbic acid in powder form

A cosmetic and/or dermatological composition in the form of a powder containing pulverulent ascorbic acid, starch and at least one anionic surfactant. In a preferred embodiment, the composition also contains a water-soluble polymer. The inventive powder composition has good foaming properties when it is moistened with water, and it is useful in particular for cleansing and/or treating the skin. The composition according to the invention is preferably contained in a sponge which is moistened with water and applied directly to the skin.

- Method and composition for the treatment of scars

A method and composition for treating hypertrophic scars so as to reduce the size and approve the appearance of scars comprises applying to the scar a composition comprising a film-forming carrier such as a Collodion which contains one or more active ingredients such as a topical steroid, silicone gel and vitamin E. Novel compositions using the Collodion film-forming carrier are also useful to treat a variety of adverse skin disorders.

- Composition with a continuous aqueous phase containing L-2-oxothiazolidine-4-carboxylic acid

A composition containing a continuous aqueous phase comprising L-2-oxothiazolidine-4-carboxylic acid, at least one sequestering agent and at least one neutralizing agent, the said neutralizing agent being present in an amount which is sufficient to adjust the pH of the aqueous phase of the composition to a value of between 5 and 8. The combination of the sequestering agent and the neutralizing agent stabilizes the L-2-oxothiazolidine-4-carboxylic acid, in particular with respect to thermal degradation, and thus prevents yellowing of the composition and the formation of unpleasant odors.

- Pressure sensitive adhesive compositions for transdermal drug delivery devices

A transdermal drug delivery device for the controlled transdermal delivery of an active pharmaceutical agent. The device comprises a drug delivery device comprising an active pharmaceutical agent and a means for its controlled delivery through the skin; and (B) a silicone pressure sensitive adhesive for maintaining contact between the device and the skin of a wearer. The silicone pressure sensitive adhesive comprises silicone resin copolymer and a polydiorganosiloxane and has a silanol concentration in the range of between about 8000 and about 13,000 ppm. The present invention also relates to methods for producing the above silicone pressure sensitive adhesive compositions.

- Reparatives for ultraviolet radiation skin damage

A composition of L-glutathione (reduced) and selenium and an epidermal growth factor in a topical carrier and method of using the composition to reduce and repair ultraviolet radiation-induced skin damage, both acute injury (sunburn) and chronic damage (photoaging and cutaneous malignancies).

- Transfer-resistant make-up or care composition containing a volatile linear silicone

A transfer-resistant make-up or care composition, comprising: a fatty phase, and a volatile solvent comprising a linear decamethyltetrasiloxane and at least one additional solvent which has an evaporation speed that is greater than the evaporation speed of the linear decamethyltetrasiloxane.

- Cleansing articles for skin and/or hair which also deposit skin care actives

The present invention relates to a substantially dry, disposable, personal cleansing article useful for both cleansing the skin or hair and delivering skin care actives onto the skin or hair. These articles are used by the consumer by (i) wetting the dry article with water and (ii) generating lather by subjecting the wetted article to mechanical forces, e.g., rubbing. The article comprises a water insoluble substrate, a lathering surfactant, and a skin care active component. Preferably, the articles of the present invention further comprise a deposition aid and/or a conditioning component.

- Topical aqueous gel composition

An aqueous solid topical composition comprising a matrix, i.e., an aqueous solid matrix, having the appearance of a gel and possessing the following rheological profile: an initial viscosity at rest V.sub.0 sufficient to form a solid composition, preferably ranging from 50,000 to 1,000,000 Pa.multidot.s, said viscosity V.sub.0 being stable up to a shear strain C.sub.1, a viscosity V.sub.2 after shear at a strain C.sub.2 for which the ratio V.sub.0 /V.sub.2 is greater than or equal to 1000:1, the difference C.sub.2 -C.sub.1 being less than or equal to 1000 Pa, and which may be useful as a make-up, styling, body hygiene or care composition.

- Use of a non-mammalian DNA virus to express an exogenous gene in a mammalian cell

Disclosed are methods, nucleic acids, and cells for expressing an exogenous gene in a mammalian cell, involving introducing into the cell a non-mammalian DNA virus (e.g., a baculovirus) whose genome carries an exogenous gene, and growing the cell under conditions such that the gene is expressed. Also disclosed are methods for treating gene deficiency disorders, neurological disorders, or cancers in a mammal by providing to a cell a therapeutically effective amount of a virus whose genome carries an exogenous, therapeutic gene and growing the cell under conditions such that the exogenous gene is expressed in the mammal.

- Device including a chromophoric composition to be applied to the skin, a method of fabricating such a device, and uses therefor

The invention relates to device making it possible to apply a chromophoric composition to the skin, said device including a chromophoric composition containing at least one chromophoric agent. The chromophoric composition is in the form of a layer of constant thickness bonded to one face of backing, at least prior to being applied to the skin, the chromophoric agent or agents being distributed uniformly in said composition, and the type of the composition being chosen such that light energy from laser radiation is transformed locally into heat and/or the chemical structure(s) of the chromophoric agent(s) is/are modified locally.

- Oil-in-water emulsion containing C10-C24 fatty acid derivatives for treating skin of mammals

An oil-in-water emulsion for application on a skin surface is disclosed. The emulsion comprises an oily phase and an aqueous phase. The oily phase comprises a first lipid of vegetable or animal origin. The emulsion is stabilized by containing at least one surfactant/emulsifier. The surfactant/emulsifier is substantially removed from a skin surface onto which the emulsion has been applied and from the emulsion by flushing with a liquid, thereby leaving at least a part of the oily phase on the skin. When the emulsion is diluted with tap water, which has a degree of hardness of about 18 degrees in a volume of 100 parts of water to one part of the emulsion at ambient temperature, it is separated into at least two distinct phases after standing for 24 hours at ambient temperature. The emulsion has a pH value of at least about 6 and at least about 50% w/w of the total concentration of the surfactant/emulsifier which is a fatty acid derivative. The fatty acid derivative has a fatty acid component which is a saturated or unsaturated C.sub.10 -C.sub.24 hydrocarbon carboxylic acid or mixtures thereof. The emulsion can be used in a method for cleansing or conditioning a skin surface, for treating human skin, for treating mammals against parasites belonging to the phylum Arthropoda and for protecting human skin against the sun.

- Make-up removing and/or cleansing cosmetic composition in the form of a water-in-oil emulsion

The invention relates to a make-up removing and/or cleansing cosmetic composition in the form of a water-in-oil emulsion and comprising (1) at least one silicone emulsifier, (2) at least one branched-chain hydrocarbonaceous oil and (3) at least one make-up removing oil chosen from esters of a fatty acid comprising at least 12 carbon atoms. The composition is fluid and may be used, for example, to remove make-up from the skin without any nuisance or irritation and with excellent effectiveness.

- Polymer glucan ether derivatives, their manufacturing as well as their use

A method for treatment of skin includes topical application of a composition containing a therapeutically effective amount of a 1,3-beta-glucan ether derivative. Such application effectively provides treatment and/or prophylaxis of various skin-related problems, such as neurodermatitis and psoriasis, and reduces the evidence of aging by minimizing wrinkles. In an advantageous embodiment, the glucan ether derivative is present in the composition in a range of concentration of about 0.002% to about 8% by weight. In another embodiment the glucan ether derivative is advantageously carboxymethyl glucan sodium salt.

- Self-tanning composition

By combining dihydroxyacetone as the active skin coloring agent in combination found with a blend of dispersion polymers and polyester polymers, an easily employed, self-tanning formulation is realized which produces a long lasting, naturally appearing coloring of the skin without any orange pigmentation being produced. In addition, tan colored skin produced by the present invention maintains the desired color for extended periods of time. In the present invention, the dispersion polymers stabilize the dihydroxyacetone as well as provide a thickening agent for the composition. In addition, the present invention also incorporates an oil soluble polyester polymer in combination with the other ingredients which achieves a formulation which provides a slow release of the active ingredient.

- Oil-in-water emulsions containing a 1,3,5-triazine derivative and a copolyol silicone and cosmetic applications

The present application relates to novel oil-in-water emulsions comprising i) at least one specific 1,3,5-triazine derivative and ii) at least one polyalkyl-polyethersiloxane carrying polyoxyalkylene groups grafted onto the main silicone chain; with the proviso that the said emulsions do not comprise cetylstearyltrimethylammonium chloride. Another subject-matter of the present invention is the use of such emulsions in the manufacture of cosmetic or dermatological compositions intended for the photoprotection of the skin and/or hair and/or other keratinous substances against ultraviolet radiation, in particular solar radiation.

- Treating skin wrinkles/fine lines with calcium channel inhibitors

A regime or regimen for loosening/slackening and/or relaxing cutaneous and/or subcutaneous human skin tissue, advantageously for cosmetically/therapeutically treating skin wrinkles and fine lines, comprises administering to a candidate subject in need of such treatment, a thus-effective amount of at least one inhibitor of at least one calcium channel.

- Plant polar lipid permeation enhancer in a cosmetic pad for improving skin appearance

Devices for the improvement of skin appearance are provided, said devices including a pad with a backing layer, a release layer, and a vehicle located therebetween, the vehicle containing a cosmetic formulation and a skin permeation enhancer, wherein the skin permeation enhancer includes a plant polar lipid. The invention also relates to a method of improving skin appearance using the devices of the invention.

- Lipid extract having anti-inflammatory activity

Anti-inflammatory, and particularly anti-arthritic, treatment of a human or animal patient comprises administration to the patient of an effective amount of a lipid extract of Perna canaliculus or Mytilus edulis.

- Skin treatment cream

A clear, transparent highly stable skin moisturizing and lubricating composition is provided comprising the product obtained by combining polyglyceryl methacrylate with a pharmaceutically acceptable silicone, in the presence of a suitable emulsifier under application of pressure in the range of about 13,000 to about 50,000 psi. The compositions are adapted for use as cosmetics and/or carriers for active drugs and serve in this form for treatment of skin irritations, burns, skin infections and the like. A method of preparing the compositions of the invention is disclosed. The invention also contemplates methods for lubricating and moisture replenishment of the skin, treating burns, skin infections and the like by topically applying the disclosed skin treatment compositions of the invention.

- Nitroimidazole gel composition

A viscous hydrogel composition, for use in a topical treatment of a skin condition involving dry or inflammed skin, comprising an antimicrobially active nitroimidazole drug, a water miscible alkylene glycol, a bydroxyalkyl cellulose gelling agent and water, buffered to have a physiologically acceptable pH and a method of making the same.

- Cosmetic or dermatological composition containing at least one extract of mulberry, at least one extract of skullcap and at least one salicylic acid derivative

A cosmetic or dermatological composition, comprising: in combination, at least one extract of mulberry or an active substance isolated from the extract, at least one extract of skullcap or an active substance isolated from the extract and at least one salicylic acid derivative or salt thereof.

- Self dosing skin preparation

A self dosing skin composition and method releases sun blocking agent or other active ingredient onto the skin of a user as a function of exposure to at least one environmental condition over time. The environmental condition is preferably exposure to sun light, in particular, harmful UV radiation. The composition includes a medium adapted to be spread onto the skin of a user and a reservoir defining at least one wall for containing at least one sun blocking or other agent. The reservoir is dispersed in the medium and the wall is designed and/or selected to deteriorate over time with exposure to the environmental condition or conditions, for releasing the agent into the medium and onto the skin. At least one agent is provided in the reservoir. The reservoir is preferably in the form of a multiplicity of microcapsules dispersed in the medium, each microcapsule having a wall containing the at least one agent, each wall deteriorating over time with exposure to the at least one environmental condition for opening the microcapsule to release the agent.

- Method and topical treatment composition for herpesvirus hominis

Improved topical treatment of active phase lesions resulting from recurrent viral infection by herpes simplex virus which includes the use of two primary agents, namely, an aqueous solution of benzalkonium halide, preferably benzalkonium chloride, and a dry form of the herb Echinacea purpurea, preferably in powder form. Active phase herpes lesions are wetted with the benzalkonium chloride solution and dusted with the powder form of Echinacea purpurea to create a coating on the wetted lesion surface. The coating is maintained on the lesion throughout treatment, and unexpected rapid resolution of the lesions results.

- External preparation for skin

The object of the invention is to provide a new external preparation for skin having high melanine formation inhibition and also anti-aging effect, and desired drug effect can be obtained without degradation in a pharmaceutical preparation. The external preparation for skin includes the extract of Pueraria mirifica in conbination with an active ingredient selected from the group consisting of a whitening agent, an anti-oxidant, an anti-inflammation agent, an ultraviolet-ray shielding ingredient, a cell activation agent and humectant.

- Cosmetic or dermatological composition forming, on a keratin substrate, a film in cross-linked hybrid material

The invention concerns a cosmetic or dermatological composition designed for for forming a film on a keratin substrate, in cross-linked hybrid material. Said composition is of the sol/gel type and is obtained by mixing: (a) at least an organometallic compound; (b) at least a functionalised organic polymer or said polymer precursor, or at least a functionalised silicone polymer or said polymer precursor, the precursor being different from (a); (c) a sufficient amount of water for hydrolysing the organometallic compound: and (d) optionally at least an alcohol; said film being non-reversible.

- Agent for protecting skin and hair moisture

A skin protective agent which comprises as a sole ceramide component the erythro (2S, 3R) type of a ceramide and has a remarkably excellent water-barrier ability.

- System for percutaneous delivery of opioid analgesics

Compositions and methods for the topical delivery of loperamide hydrochloride are disclosed. Novel solvent mixtures have been found to be beneficial in enhancing the penetration of loperamide hydrochloride through the skin.

- Personal care product in the form of a free-standing stick

A new personal care product in the form of a free-standing stick comprises an inner core with cosmetic ingredients and an solid outer shell adhering to the inner core, in which the outer shell is wax-free and contains at least solid proteins, liquid polyols or solutions of polyols, solid polyols, emollients and additional cosmetic auxiliary materials and active ingredients. The outer surface does not transfer pigment through brief contact with the skin and is also not sticky.

- Stable W/O/W emulsion and its use as cosmetic and/or dermatological composition

A water/oil/water triple emulsion comprising an aqueous external phase and a W/O primary emulsion comprising an oily phase and an aqueous internal phase, which comprises at least one partially or completely crosslinked organopolysiloxane elastomer comprising a polyoxyethylenated and/or polyoxypropylenated chain. The emulsion may be used, for example for cleansing and/or treating and/or protecting the skin and/or mucous membranes and/or keratinous fibers.

- Composition in the form of an O/W emulsion with a high wax content, and uses thereof in cosmetics and dermatology

A creamy composition in the form of an oil-in-water emulsion comprising an oily phase dispersed in an aqueous phase, characterized in that it contains at least one anionic emulsifier which is liquid at room temperature, and at least 5% by weight of one or more waxes relative to the total weight of the composition, and in that the oily phase is in the form of a soft paste at room temperature. The anionic emulsifier is preferably a surfactant containing a phosphate group, such as octyldecyl phosphate. The present invention also relates to the uses of the said composition in cosmetics and dermatology, in particular for caring for, treating and/or making up the skin and/or mucous membranes, and more particularly for treating wrinkles and/or fine lines of the skin and/or for treating dry skin. The invention also relates to a process for preparing this composition, characterized in that at least one step of the process is carried out using a mixer-extruder.

- Concentrated liquid accumulations comprising a microbicidally active ingredient

There are described concentrated liquid formulations (a) comprising (a.sub.1) 1 to 80% by weight of a microbicidally active ingredient, (a.sub.2) 20 to 99% by weight of a mono- or dihydric alcohol or mixtures thereof, and concentrated liquid formulations (b) comprising (b.sub.1) 5.1 to 30% by weight of microbicidally active ingredient, (b.sub.2) 0 to 80% by weight of sulfonate, (b.sub.3) 1 to 60% by weight of a C.sub.1 -C.sub.11 monocarboxylic acid or of a C.sub.3 -C.sub.12 di- or -polycarboxylic acid; (b.sub.4) 0 to 90% by weight of a mono- or dihydric alcohol or mixtures thereof, and water to 100%, it always being necessary for one of the components (b.sub.2) or (b.sub.4) to be present. The formulations according to the invention are used as microbicidally active ingredient in cosmetic products, household articles or hand disinfectants, as preservatives in household articles and cosmetic products and as disinfectant and decontamination agent for textile fibre materials or the skin and hard surfaces.

- Photochromic tanning and sunscreen lotion

A photochromic tanning and sunscreen lotion having photochromic compounds that change color upon exposure to sunlight or other sources of ultraviolet radiation (UV) to create the appearance of a tanned skin, and which also form a shield against UV radiation to thereby provide an effective sunscreen.

- Cosmetic compositions

Antiperspirant compositions herein comprise an antiperspirant active, together with a carrier and a structurant for the carrier which comprises an organic wax having a melting point of from 40 to 90.degree. C. of which at least 60% of the weight of the wax is provided by at least one aliphatic ester satisfying the formula: in which n is from 9 to 39 and m is from 0 to 35 to form a solid or a soft solid. The compositions can be anhydrous, in the form of a suspension of antiperspirant active, or can comprise aqueous emulsions. The formulations structured by the selected waxes provide lower visible deposits on topical application compared with conventional wax-structured formulations and the waxes are effective at structuring/thickening at a proportion below that in conventional wax-structured formulations. It is especially desirable to employ emulsion formulations comprising a continuous phase which comprises from 10 to 35% volatile silicone oil, and from 5 to 15% non-volatile hydrophobic oil, from 40 to 75% of ta disperse aqueous phase which contains from 1 to 35% of an antiperspirant or deodorant active, from 7 to 25% of a wax structurant, from 0.1 to 10% of an emulsifier, and preferably contains up to 5% insoluble particulate materials, % s being by weight based on the composition.

- Antiperspirant formulations

Anhydrous antiperspirant formulations in which a particulate antiperspirant active is suspended in a carrier fluid can result in significant visible deposits when applied to skin or when transferred onto clothing. Anhydrous antiperspirant suspension sticks which exhibit very low visible deposits are obtainable by employing a carrier fluid in which at least 45% and preferably at least 60% of its weight comprises an oxygen-containing emollient oil having a refractive index of at least 1.465, in conjunction with structurant comprises a wax or a non-polymeric fiber-forming gellant, excluding certain gellants or gellant combinations. Preferred emollient oils include alkyl benzoates and alkylphenylsiloxanes. The waxes can even comprise fatty alcohols.

- Cosmetic composition in anhydrous form comprising a dispersion of a surface-stabilized polymer particles

The present invention relates to a composition, in particular a cosmetic or dermatological composition, for caring for and/or making up the skin, that includes: a liquid fatty phase including polymer particles that are dispersed and surface-stabilized therein, and a dyestuff, wherein the liquid fatty phase includes a volatile liquid phase and a non-volatile liquid phase, the non-volatile phase having a solubility parameter .delta..sub.h.ltoreq.5 (J/cm.sup.3).sup.1/2 and wherein a volatile phase/non-volatile phase weight ratio ranges from 2 to 25. This composition makes it possible to obtain on the skin a flexible, comfortable, non-greasy film which can camouflage marks, dyschromia and couperose on the skin. The invention also relates to a process for camouflaging marks and other dyschromia on the skin.

- Method and compositions for treatment of fungal nail disease

Compositions for the treatment of fungal nail disease (onychomycosis), including camphor, menthol, eucalyptus and thymol are described. The ingredients are natural and very effective in treating the nail fungus.

- Use of amino phenol amide derivatives as depigmentation agents

The invention relates to the use of aminophenol amide derivatives in a composition as an agent for depigmenting and/or bleaching human skin, body hairs and/or head hair. The invention also relates to a process for depigmenting and/or bleaching the skin, body hairs and/or head hair, which consists in applying a composition comprising aminophenol amide derivatives to human skin, body hairs and/or head hair.

- Topical skin sensitizer

A topically applied aphrodisiac dispersed in a manually applied vehicle which substantially increases tissue sensation. The active ingredients are benzalkonium chloride, aloe and vitamin E in a water soluble gel which includes sorbitol, glycerin, and hydroxethylcellulose.

- Liquid dispersion polymer compositions, their preparation and their use

Liquid dispersion polymer compositions which comprise microparticles of a hydrophilic, water soluble or swellable polymer, preferably an acrylic-based polymer, dispersed in a di- or triglyceride oil such as soybean oil and an oil-in-water surfactant, are useful to prepare microparticulate thickening systems to thicken aqueous or aqueous/organic compositions, particularly for use in personal care and pharmaceutical formulations. The preparation and the use of these liquid dispersion polymer compositions is described.

- Detergent cosmetic compositions comprising an anionic hydroxyalkyl ether surfactant and a silicone, and their uses

The invention relates to novel detergent cosmetic compositions comprising, in a cosmetically acceptable medium, at least one anionic surfactant chosen from 2-hydroxyalkyl ether carboxylic acid and salts thereof and at least one silicone chosen from: (i) volatile or non-volatile, linear, branched or cyclic and crosslinked or non-crosslinked polyalkylsiloxanes, polyarylsiloxanes or polyalkylarylsiloxanes; (ii) polysiloxanes comprising, in their general structure, one or more organofunctional groups chosen from: a) substituted or unsubstituted aminated groups; b) (per)fluorinated groups; c) thiol groups; d) carboxylate groups; e) hydroxylated groups; f) alkoxylated groups; g) acyloxyalkyl groups; h) amphoteric groups; i) bisulphite groups; j) hydroxyacylamino groups; k) carboxylic acid groups; l) sulphonic groups; m) sulphate or thiosulphate groups; (iii) linear polysiloxane(A)-polyoxyalkylene(B) block copolymers of (A--B).sub.n type with n>3; (iv) grafted silicone polymers composed of a main chain not comprising silicone; and (v) grafted silicone polymers composed of a polysiloxane main chain.

- Composition and method for enhanced transdermal absorption of nonsteroidal anti-inflammatory drugs

A novel topical formulation for delivery of nonsteroidal anti-inflammatory drugs (NSAIDs) is characterized by enhanced transdermal absorption and efficacy. A two phase liquid composition has aqueous and oil phases, the oil phase having a relatively high concentration of the NSAID to enhance transdermal absorption and efficacy when incorporated into the topical anti-inflammatory formulation. The two phase liquid composition preferably contains, in addition to an NSAID, at least one melting point depressing agent. A preferred topical anti-inflammatory composition includes S(+)-ibuprofen, thymol, and ethyl alcohol or isopropyl alcohol.

- Androgenic steroid compounds and a method of making and using the same

An androgenic steroid compound of the formula: ##STR1## wherein: X Y, Z, R.sup.1, R.sup.2, R.sup.3, R.sup.5 and R.sup.6 are as defined herein.

- Aqueous agents for combating parasitic insects and acarina in human beings

The present invention relates to water-containing formulations for the dermal control of parasitic insects and mites on humans, said formulations having the following composition: a--agonists or antagonists of the nicotinic acetylcholine receptors of insects in a concentration of from 0.0001 to 7.5% by weight, based on the overall weight of the formulation; b--water in a concentration of from 20 to 50% by weight, based on the overall weight of the formulation; c--acyclic alcohols in a concentration of from 20 to 50% by weight, based on the overall weight of the formulation; d--solvents from the group consisting of cyclic carbonates and lactones in a concentration of from 2.5 up to 20.0% by weight, based on the overall weight of the formulation; e--optionally further auxiliaries from the group consisting of thickeners, spreading agents, colorants, antioxidants, propellants, preservatives, tackifiers, emulsifiers, in a concentration of from 0 up to 30% by weight, based on the overall weight of the formulation.

- Products for topical applications comprising oil bodies

The present invention provide novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.

- Synthetic peptides and their use in cosmetic or dermopharmaceutical compositions

The invention concerns the use of peptides of general formula R1-L-Tyr-L-Arg-R2 in which R1=H or a R3-C=0 with R3=a C1 to C20 alkyl chain, linear or branched, saturated or unsaturate, hydroxylated or not, or with R3=an aryl, aryl-alkyl or alkyloxy or aryloxy or arylalkyloxy group, and in which R2=OH or a O-R4 group with R4=a C1 to C20 alkyl chain, or R2=a NH2, NHX or NXX group with X=a C1 to C4 alkyl chain. The peptides have a soothing effect on the skin, including by topical application, and attenuates the effects of benign skin sores (after shave irritation, sunstroke, frostbite, chaps, depilation). They are used in acceptable cosmetic excipients and in effective in vivo concentrations.

- Active control surface modal system for aircraft buffet and gust load alleviation and flutter suppression

The present invention relates to an Active Control Surface Modal (ACSM) device that generates unsteady aerodynamic damping to alleviate aeroelastic structural instability, vibration and dynamic loads. An active control surface modal deformation is created by means of a pair of antagonistically activated actuators. Since the masses of upper and lower surface skins are lighter, the modal deformations can be activated at high frequencies that can encompass wide band spectrum of buffet, gust and flutter problem areas. An independent dosed loop active control system is used to activate the ACSM modes. Measured acceleration sensors are used as the feedback signals to compute the coefficients of the control law that is designed to suppress the dynamic environments such as buffet, gust and flutter. Then a computerized control system algorithm outputs a series of voltage signals that pass through power amplifiers to activate the actuators. Then the ACSM device generates unsteady aerodynamic damping in out-of-phase with the external (buffet/gust) or self excited air loads (flutter) to reduce or eliminate the undesirable dynamic effects on the aircraft. Some buffet analyses of a vertical tail, typical of a fighter aircraft, show 80 per cent reduction in peak stress, which amounts to an eight fold fatigue life extension of the vertical tail.

- Photoprotective cosmetic composition containing an anionic surfactant, compounds for screening out ultraviolet radiation and a cationic or zwitterionic amphiphilic compound, and use thereof

The invention relates to a cosmetic composition, in particular for photoprotecting the skin and/or the hair, in the form of a dispersion comprising two immiscible phases stabilized with at least one anionic surfactant chosen from the salts of fatty acids and of monovalent or polyvalent metals, of ammonium or of organic bases, a compound for screening out ultraviolet radiation, which can be adsorbed at the interface of the said immiscible phases, derived from benzylidenecamphor and comprising at least one partially or totally neutralized sulphonic acid function, a metal oxide nanopigment coated with hydrophobic hydrocarbon-based coating agents and a cationic or zwitterionic amphiphilic compound which leads, with the anionic surfactant, to the formation of a compound capable of lowering the water/liquid paraffin interface tension at 40.degree. C. by more than 14 mN.m.sup.-1 for an anionic surfactant concentration of 0.1 mmol/100 g, by more than 26 mN.m.sup.-1 for an anionic surfactant concentration of 0.5 mmol/100 g and by more than 33 mN.m.sup.-1 for an anionic surfactant concentration of 1 mmol/100 g.

- Antiperspirant and deodorant compositions containing a low molecular weight polyethylene gellant

The present invention embraces an anhydrous topical antiperspirant or deodorant composition comprising an antiperspirant or deodorant active, a dermatologically acceptable volatile silicone liquid carrier vehicle and a polyethylene homopolymer dissolved in the vehicle to serve as a thickening or solidifying agent, wherein the polyethylene homopolymer has a molecular weight of about 200 to about 800 daltons, preferably about 300 to about 600 daltons, most preferably about 400 to about 500 daltons. The composition should be substantially free of any other organic or natural waxes. The present invention also embraces a method of inhibiting or reducing perspiration or a method of inhibiting or reducing malodor by topically applying an effective amount of such an antiperspirant composition or deodorant composition to the skin.

- Nanoemulsion based on ethoxylated fatty ethers or on ethoxylated fatty esters and its uses in the cosmetics, dermatological and/or ophthalmological fields

The present invention provides a nanoemulsion, that includes: an oily phase dispersed in an aqueous phase; and at least one surfactant that is solid at a temperature of less than or equal to 45.degree. C. and which is selected from the group including ethoxylated fatty ethers and ethoxylated fatty esters, and mixtures thereof; wherein the oily phase includes oil globules having a number-average size of less than 100 nm; wherein the oily phase includes at least one oil having a molecular weight of greater than 400; and wherein a weight ratio of the oily phase to the surfactant ranges from 2 to 10. The invention also provides a process for making the nanoemulsion, and methods for its use. The emulsion is ideally transparent and stable on storage. It can ideally contain large amounts of oil while retaining good transparency and good cosmetic properties. The nanoemulsion is particularly useful in compositions, including topical, pharmaceutical, cosmetic, opthalmic, ophthalmologic. The composition is also particularly useful in applications to the skin, hair, scalp, mucous membranes, and eyes.

- Skin cleansing composition for removing ink

A skin cleansing composition suitable for removing ink and other stains from the hands and arms of a user includes an effective amount of a low molecular weight alcohol having from one to twelve carbon atoms and an effective amount of a peroxide releasing agent, e.g., a perborate salt, preferably sodium perborate, such that together, the alcohol and perborate salt provide a synergistic reaction that effectively removes ink from the skin of the user. Other additives such as fillers, abrasives, and detergents may be employed to provide further cleansing action.

- Photoprotective/cosmetic compositions comprising novel benz-x-azole-substituted silane/siloxane sunscreens

Photoprotective, topically applicable sunscreen/cosmetic compositions well suited for the UV-photoprotection of human skin and/or hair, comprise an effective UV-photoprotecting amount of at least one novel benz-x-azole-substituted silane or siloxane having the formula (1) or (2): ##STR1## A--SiR'.sub.1 R'.sub.2 R'.sub.3 (2) in which A is a radical having the structural formula (I): ##STR2##

- Photoprotective/cosmetic compositions comprising aminoamidine sunscreens

Topically applicable sunscreen/cosmetic compositions well suited for the photoprotection of human skin and/or hair against the damaging effects of UV-irradiation, particularly solar radiation, comprise an effective UV-photoprotecting amount of at least one characteristically novel aminoamidine compound, advantageously having the structural formula (I): ##STR1## formulated into a topically applicable, cosmetically acceptable vehicle, diluent or carrier therefor.

- Pharmaceutical composition comprising a suspension for the active ingredient

A pharmaceutical formulation may be prepared by a method comprising providing the active ingredient in solution in a pharmacologically-acceptable base and mixing the resulting solution with a pharmacologically-acceptable acid in an amount such that the formulation attains a pH in the range of from about 3.5 to about 8.5 to thereby precipitate out the active ingredients, a viscosity-enhancing agent having been incorporated in the formulation prior to or during the mixing with acid. The formulation is suitable for administration of a pharmacologically active ingredient which is sparingly soluble in water at a pH acceptable for administration, for example to the eye of the patient.

- Use of plant extracts for treatment of acne and furuncle

Novel herbal extracts provide potent efficacy in the treatment of acne and furuncle. The formulated extracts of Momordica charantia L. are from either the whole plant or parts of the plant. The extracts have been formulated into aqueous solution, pads, and/or lotion. These formulations have been provided to treat acne and furuncle 2 to 3 times a day. It has demonstrated the ability to manage various grades of acne, from mild, moderate to severe, which include comedos, papules, pustules and nodules. Significant improvement is visible within five days. There are no observed either long-term or short-term side reactions.

- Anhydrous antiperspirant and deodorant compositions containing a solid, water-soluble, skin active agent

Disclosed are anhydrous antiperspirant and deodorant compositions that comprise from about 0.1% to about 30% by weight of an antiperspirant or deodorant active; from about 0.1% to about 20% by weight of a water-soluble, skin active solid (e.g., solid, water-soluble vitamins or other nutrients) other than the antiperspirant or deodorant active; from about 0.1% to about 40% by weight of a suspending agent; and from about 10% to about 99% by weight of an anhydrous carrier liquid, wherein the composition is substantially free of nonvolatile organic liquids having a C log P value greater than about 7.0. The anhydrous compositions allow the water-soluble skin active solids to release into the sweat or other moisture on the skin more rapidly or to a greater extent, thus enhancing any skin active effect resulting from such active materials contacting the skin, especially the underarm area of skin.

- Retinyl carbonate derivatives, preparation process and uses

The present invention relates to novel retinol derivatives having the formula (I): ##STR1## and to processes for preparing them. The invention also relates to the use of these compounds in or for the preparation of compositions intended for treating conditions of the skin or scalp, for example in preventing or combating acne and/or chronological or actinic ageing of the skin.

- Disposable article having a responsive system including an electrical actuator

Disposable articles such as diapers, incontinent briefs, diaper holders and/or inserts, training pants, feminine hygiene garments, tampons and the like having a responsive system including an electrical actuator. The responsive system may respond continuously or discontinuously. A continuous responsive system of the present invention further includes a feedback control loop. A discontinuous responsive system of the present invention may include either a feedback control loop or an open loop.

- Antiperspirant compositions

Soft solid antiperspirant formulations in which a particulate antiperspirant active material is suspended in a continuous phase containing a water-immiscible liquid which is structured by specified proportions of an organic polymeric thickener and a second structurant selected from fibre-forming structurants and waxes (often other than fatty alcohols) or a mixture of both. Such soft solid formulations avoid or minimise problems inherent in production of many published formulations such as sensitivity to small changes in concentration of the structurant.

- Topical low-viscosity gel composition

A composition is provided that has a viscosity of less than about 15,000 cP and a pH of about 3.0 to 9.0 for treating a skin disorder in a human subject. The composition consists essentially of (a) a therapeutically-effective amount of at least one compound useful for treating such disorder, (b) a pharmaceutically-acceptable, lightly cross-linked polyacrylic acid polymer compatible with the compound, (c) optionally a water miscible solvent, (d) optionally a preservative, (e) optionally an oil phase component and suitable surfactant, and (f) water. The composition is useful for treating an inflammatory skin disorder, acne, or rosacea. The low viscosity composition has an advantage of being administered more accurately when combined with a container that administers the composition as drops.

- Safe transport gel for treating medical instruments

A method for treating medical instruments after a surgical procedure, which leaves blood or other body fluid on the instrument, includes applying a gel composition that inhibits the fluid from drying on the instruments. The gel composition is preferably a low viscosity gel exhibiting both sufficient flow and coating characteristics. The viscosity is preferably from about 700 to about 4,000 centipoise (cps), preferably around 3,000 cps. Applying a gel to post-surgical medical instruments contains and keeps protein containing fluids moist for extended periods of time and facilitates subsequent transportation, cleaning, and sterilization of such instruments.

- Antimicrobial cosmetic compositions

The present invention relates to cosmetic or pharmaceutical formulations for topical application which comprises an anti-inflammatory effective amount of 3-furan carboxylic acid. The formulation also optionally comprises an anti-irritant effective amount of frulic acid and an antimicrobial effective 2-furan carboxylic acid.

- Skin care compositions

Disclosed are skin care compositions that are emulsion formulations comprising an aqueous phase, an oil phase, at least one emulsifier, and an epichlorohydrin cross-linked glyceryl starch.

- Composition for the treatment of burns, sunburns, abrasions, ulcers and cutaneous irritation

A composition having analgesic, antiseptic and skin healing promoting activity, suitable for the treatment of burns, sunburns, scalds, irritation, sores and abrasions which includes, as active ingredients, chlorophyll, cod liver oil, and camphor, preferably together with a natural antiseptic agent chosen from niaouli oil, thyme oil, and mixtures thereof, in a pharmaceutically acceptable vehicle for topical application.

- Soybean protein nutraceuticals

The invention provides methods and comprisitions for delivering effective amounts of lunasin as a nutraceutical. The general formulation comprises a composition comprising an active unit dosage of a lunasin polypeptide and a pharmaceutically acceptable excipient. The formulations may be delivered or administered by oral ingestion, by topically contacting skin using well known techniques for dermal delivery, by introducing into a retained physiological fluids. The invention also provides methods for making the subject formulations by purifying lunasin polypeptides to the requisite purity, and combining said lunasin polypeptide with a pharmaceuitcally acceptible excipient in an orally active unit dosage. The lunasin source material may be soybeans, a recombinant lunasin polypeptide expression system, a synthetically produced lunasin, or extract or fraction thereof.

- Method for preparation and use of paste formed by controlled reaction of sucralfate with hydrochloric acid

Disclosed is a sucralfate composition which is employed in the treatment of lesions. The composition is formed by the reaction between sucralfate and hydrochloric acid prior to dosing under controlled conditions which limit the reaction to an incomplete stage. The present invention contemplates various methods of achieving this incomplete reaction. In one example, a volume of sucralfate is mixed with a volume of hydrochloric acid. In additional examples, the sucralfate is first wetted in water before being mixed with the hydrochloric acid. Still yet another example involves mixing a volume of sucralfate powder with a powdered excipient before being mixed with the hydrochloric acid.

- Use of carbohydrates for promoting skin desquamation

The use of carbohydrate derivatives in or for making a topical composition for promoting skin exfoliation is disclosed. The use of said composition of controlling intrinsic and extrinsic skin ageing, as well as a non-therapeutic skin treatment method for skin exfoliation, are also disclosed.

- Cosmetic skin conditioning compositions containing red yeast rice extract

Cosmetic methods and compositions for conditioning human skin by topical application to the skin of cosmetic compositions containing red yeast rice extract. Cosmetic compositions containing red yeast rice extract in combination with ascorbyl palmitate, or sodium ascorbyl phosphate, or retinol, or retinyl ester are also disclosed.

- Anhydrous composition containing a volatile fluoro compound, and uses thereof, in particular cosmetic uses

An anhydrous cosmetic composition comprising, in a fatty phase, at least one elastomeric, solid polyorganosiloxane which is at least partially cross-linked and at least one volatile fluoro oil with a density of greater than 1.

- Transdermal preparation contacting a loratidine metabolite with antihistaminic activity

A transdermal patch contains an active loratidine metabolite contained with polyacrylate polymer matrix. The transdermal patch provides pharmaceutically useful transdermal flux rates over time.

- Antiparasitic composition for the treatment and protection of pets

Composition which is useful in particular for the treatment and protection of domestic animals which are infested with parasites or are likely to be infested with them, these compositions comprising, in the form of a ready-to-use solution: a) an insecticidal active substance of formula (I), ##STR1## b) a crystallization inhibitor, c) an organic solvent having a dielectric constant of between 10 and 35, preferably of between 20 and 30, d) an organic co-solvent having a boiling point below 100.degree. C., preferably below 80.degree. C., and a dielectric constant of between 10 and 40, preferably of between 20 and 30.

- Self-tanning cosmetic compositions

Novel cosmetic compositions for artificially tanning the skin, comprising at least one self-tanning agent, in particular DHA, and at least one dendrimer.

- Method and agents for permanently styling hair, with a base consisting of N,N-disubstituted mercaptoacetamides

The present invention relates to a composition and method for permanently shaping hair, in which an N,N-disubstituted mercaptoacetamide of the formula I: ##STR1## or a salt thereof, wherein R.sub.1 and R.sub.2 are each independently selected from the group consisting of straight-chain alkyl groups having 1 to 6 carbon atoms, branched-chain alkyl groups having 1 to 6 carbon atoms, monohydroxyalkyl groups having 1 to 6 carbon atoms, polyhydroxyalkyl groups having 1 to 6 carbon atoms and carboxyalkyl groups having 1 to 6 carbon atoms, is employed as keratin reducing agent. A process for making these mercaptoacetamides is also described as well as a novel mercaptoacetamide, N-ethyl-2'-hydroxyethyl-mercaptoacetamide. The mercaptoacetamides provide gentle and uniform shaping of hair in a pH range of 4.5 to 9.5 and do not cause allergic or sensitizing reactions.

- Sea cucumber carotenoid lipid fraction products and methods of use

Methods and compositions of matter are described for treatment of inflammatory autoimmune and other diseases by administration of lipid fractions of sea cucumber tissue. Compositions of matter useful for inclusion in aquatic and human diets are also disclosed.

- UV-photoprotecting W/O emulsions comprising micronized insoluble screening agents & nonscreening oxyalkylenated silicones

Topically applicable, water-resistant cosmetic/dermatological water-in-oil (W/O) emulsions well suited for the UV-photoprotection of human skin and/or hair comprise (a) at least one aqueous phase and (b) at least one fatty phase, (c) an effective UV-photoprotecting amount of at least one micronized organic UV-screening agent insoluble therein, the mean particle size of such micronized particles ranging from 0.01 to 2 .mu.m, and (d) at least one oxyalkylenated non-UV-screening organomodified silicone.

- Anhydrous antiperspirant and deodorant compositions containing solid d-pantothenate salts

Disclosed are anhydrous antiperspirant and deodorant compositions comprising from about 0.1% to about 30% by weight of an underarm active (antiperspirant and/or deodorant active); from about 0.01% to about 10% by weight of a solid, water-soluble, d-pantothenate salt such as calcium pantothenate; from about 0.1% to about 40% by weight of a suspending agent; and from about 10% to about 99% by weight of an anhydrous carrier liquid. Also disclosed are methods of controlling perspiration wetness and/or odor through the topical application to the underarm, especially shaven underarms, of an underarm active and a solid pantothenate salt. The anhydrous compositions are mild to the skin and can help sooth or heal skin irritated or damaged underarm skin, especially when such irritation and damage is the result of occasional or routine shaving of the underarm.

- Anhydrous antiperspirant and deodorant compositions containing a solid, water-soluble, skin active agent and glycerin

Disclosed are anhydrous antiperspirant and deodorant compositions that comprise from about 0.1% to about 30% by weight of an antiperspirant or deodorant active; from about 0.1% to about 20% by weight of a water-soluble, skin active solid (e.g., solid, water-soluble vitamins or other nutrients) other than the antiperspirant or deodorant active; from about 0.1% to about 40% by weight of a suspending agent; from about 0.1% to about 2.0% by weight of glycerin; and from about 10% to about 99% by weight of an anhydrous carrier liquid other than glycerin. The anhydrous compositions have lower visible residue on the applied areas of the skin even though they also contain relatively high residue solids in the form of water-soluble skin active solids other than and in addition to the antiperspirant and deodorant active. The compositions also provide for a dry, silky feeling during or after application.

- Utilization of an extract of a plant of the Cecropia genus

The utilization of at least one extract of a plant belonging to the cecropia genus as an active agent. The extract is used alone or in conjunction with at least one other active agent for preparing a cosmetic or dermopharmaceutical product or a cosmetic or dermopharmaceutical composition for external local application on the skin, the mucous membranes and/or the epithelial or body appendage formations.

- Antimutagenic compositions for treatment and prevention of photodamage to skin

A method of improving DNA repair and reducing DNA damage and for reducing mutation frequency in skin for the purpose of reducing consequences of exposure to solar or ultraviolet radiation is disclosed. The methods comprise administering to the skin a composition containing deoxyribonucleosides in concentrations sufficient to enhance DNA repair or reduce mutation frequency in a vehicle capable of delivering effective amounts of deoxyribonucleosides to the necessary skin cells.

- Active topical skin protectants using reactive nanoparticles

A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.

- Composition comprising particles of a hydrophilic polyorganosiloxane suspended in an aqueous phase

The invention relates to a composition for cosmetic or topical application comprising particles of an at least partially crosslinked elastomeric solid polyorganosiloxane suspended in an aqueous phase, wherein the composition is substantially water-resistant. This composition is more especially a make-up composition or a care composition for the lips or a foundation composition for making up the human face or body. This composition is soft and feels fresh when applied, it spreads easily, it is non-sticky and it does not dry out the skin or the lips. It is entirely suitable for greasy skin, on account of its high matte-effect power.

- Therapeutic compositions

The invention relates to a composition comprising, from 2 to 8% squalane, from 1.5 to 8% cyclodextrin, and from 1.5 to 8% of a pharmaceutically and/or cosmetically acceptable acid selected from aliphatic mono-, di- and .alpha.-hydroxy carboxylic acids having from 2 to 10 carbon atoms, and the balance selected from other pharmaceutically and/or cosmetically acceptable compatible anti-acne active substances as well as pharmaceutically and/or cosmetically acceptable paste, ointment or cream bases and additives. The composition has therapeutic and cosmetic effect and can be used as a cosmetic as well as for the preparation of a drug for prophylactic and curative treatment of acne. A method for the preparation of the composition as well as a method for treatment of acne is also included in the invention.

- Method for inhibiting nematocyst discharge

Compositions for inhibiting nematocyst or polar capsule discharge are provided in the form of an effective amount of antihistamine, an effective amount of antihistamine and an effective amount of at least one cation, or an effective amount of at least one cation. The compositions can be in the form of ointments or can be added to the environment surrounding the nematocysts or polar capsules. Methods of inhibiting nematocyst or polar capsule discharge using the compositions of the invention are also provided.

- Methods for altering hair growth and hair pigmentation by apoptosis in the follicular papillae and compositions therefor

The present invention utilizes serine proteases and their ability to induce programmed cell death and apoptosis in the follicular papillae to affect changes in mammalian hair growth and hair pigmentation. Also described are compositions which have an agent with a portion of similar structure to a portion of the trypsin molecule, allowing said agent to induce programmed cell death and apoptosis in the same manner as trypsin.

- UV-photoprotecting emulsions comprising micronized insoluble screening agents and associative polymers

Topically applicable, water-resistant cosmetic/dermatological emulsions well suited for the UV-photoprotection of human skin and/or hair contain an effective UV-photoprotecting amount of at least one micronized organic UV-screening agent insoluble therein, the mean particle size of such micronized particles ranging from 0.01 to 2 .mu.m, and further containing at least one associative polymer which is characteristically other than a C.sub.8 -C.sub.16 alkyl polyglucoside.

- Synergistically UV-photoprotecting benzotriazole-substituted silicon/cinnamic acid compositions

Topically applicable cosmetic/dermatological compositions suited for improvedly UV-photoprotecting human skin and/or hair against the deleterious effects of ultraviolet irradiation, advantageously oil-in-water emulsions, contain SPF-synergistically enhancing amounts of (a) at least one UV-screening benzotriazole-substituted silicon compound and (b) at least one UV-screening cinnamic acid derivative, formulated into (c) a topically applicable, cosmetically/dermatologically acceptable vehicle, diluent or carrier therefor.

- Cosmetic compositions

Compositions for application to human skin have a continuous phase which contains water-immiscible oil structured by incorporation of a compound of formula ##STR1## in which Y and Y.sup.1 are each independently --CH.sub.2 or >CO Q and Q.sup.1 are each independently a hydrocarbyl group of at least 6 carbon atoms and m is from 2 to 4. The composition may be an antiperspirant containing suspended particulate antiperspirant active or containing a dispersed phase in which antiperspirant active is dissolved in water or water-immiscible solvent.

- Antiperspirant compositions

Antiperspirant formulations containing an antiperspirant active and a continuous phase comprising a water-immiscible liquid carrier, such as, amongst other materials, cyclomethicones, that is structured using an amido-containing compound of the general formula ##STR1## in which R and R.sup.1 each independently denote a branched or unbranched moiety containing 5 to 27 carbon atoms, m and n are each independently, zero or 1, Y is a cyclohexane ring bearing the amido-containing substituent groups ##STR2## in 1,2 or 1,3 positions.

- Personal care compositions containing active proteins tethered to a water insoluble substrate

The present invention relates to personal care compositions comprising a water insoluble substrate, a plurality of active proteins, and a binding means, comprising a polymeric tether, permanently attaching each of the enzymes to the substrate wherein the personal care composition comprises from about 0.01 .mu.g/cm.sup.2 to about 1000 .mu.g/cm.sup.2 of the enzyme on the substrate.

- Water-in-oil-in-polar solvent emulsions

Water-in-oil-in-non-aqueous polar solvent W/O/PS type multiple emulsion contains a water phase W dispersed in an oil O as the first continuous phase of a primary emulsions W/O by an emulsifier. Primary emulsion W/O is dispersed in a second continuous non-aqueous polar solvent phase PS to form multiple emulsion W/O/PS. The emulsifier is a silicone elastomer containing polyether groups which is a network of polymeric molecules crosslinked with an .alpha.,.omega.-unsaturated hydrocarbon.

- Prolamin-plant polar lipid combination, preparation method and applications

The invention provides a prolamine-plant polar lipid association, wherein the prolamine and plant polar lipid components are present in such proportions so that stable films can be obtained with this association, which is preferably in the form of a hydro-alcoholic gel comprising: 20-40% w/w of prolamines, preferably gliadin; 0.1-5% w/w of ceramides, preferably wheat ceramides; hydro-ethanolic solution (35 to 80.degree.) ad 100%. This association may be used for preparing films, patches, aerosols for use in the delivery of active substances such as therapeutic and cosmetic agents.

- Active topical skin protectants using combinations of reactive nanoparticles and polyoxometalates or metal salts

A topical skin protectant formulation containing a barrier cream and a active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWAs). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.

- Active topical skin protectants containing OPAA enzymes and clecs

A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.

- Cosmetic and/or dermatological composition comprising a dispersion of a polymer system, and use of this system as a tensioning agent

The present invention relates to an anti-wrinkle composition containing a dispersion of a polymer system comprising at least one polymer of natural origin, and to the use of this polymer system as a tensioning agent in a cosmetic or dermatological composition. The polymer used must characteristically have a molecular weight of greater than 670,000 daltons and the polymer system obtained must be capable of forming a steam-permeable film, it must have a Young's modulus ranging from 10.sup.8 to 9.times.10.sup.9 N/m.sup.2 and it must produce, at a concentration of 7%, a greater than 1.5% retraction of isolated stratum corneum at 30.degree. C. and at a relative humidity of 40%. The composition obtained is used in particular for the immediate treatment of wrinkles and fine lines on the skin.

- Nanoemulsion based on alkyl ether citrates and its uses in the cosmetics, dermatological, pharmacological and/or ophthalmological fields

A nanoemulsion, the oil globules of which have an average size of less than 100 nm, comprising an anionic surfactant chosen from alkyl ether citrates and at least one oil having a molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The emulsion obtained is transparent and stable on storage. It can comprise large amounts of oil while retaining good transparency and while having good cosmetic properties. It can constitute a composition for topical use, a pharmaceutical composition or an ophthalmological composition. The invention also relates to the use of the nanoemulsion according to the invention in the cosmetics and dermatological fields, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and in the ophthalmological field, as an eye lotion for treating the eyes.

- Antimicrobial wipes which provide improved residual benefit versus gram negative bacteria

The present invention relates to an antimicrobial wipe comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active; from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant; from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent; and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0; wherein the antimicrobial cleansing composition has a Gram Negative Residual Effectiveness Index of greater than about 0.3. The invention also relates to these antibacterial wipes wherein the antimicrobial cleansing composition has a Mildness Index of greater than about 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram negative bacteria using these products.

- Methods of delivering a physiologically active polypeptide to a mammal

A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy.

- Pharmaceutical formulations of resveratrol and methods of use thereof

A method is provided for preventing or treating skin conditions, disorders or diseases, such as may be associated with or caused by inflammation, sun damage or natural aging. The method involves administration, preferably topical administration, of an active agent selected from the group consisting of resveratrol, pharmacologically acceptable salts, esters, amides, prodrugs and analogs thereof, and combinations of any of the foregoing. Pharmaceutical formulations for use in conjunction with the aforementioned method are provided as well.

- Active topical skin protectants containing polyoxometalates and/or coinage metal complexes

A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.

- Emulsifier-free UV-photoprotecting emulsions comprising micronized insoluble screening agents

Topically applicable, water-resistant but emulsifier-free cosmetic/dermatological emulsions well suited for the UV-photoprotection of human skin and/or hair contain (a) at least one aqueous phase and (b) at least one fatty phase, (c) an effective UV-photoprotecting amount of at least one micronized organic UV-screening agent insoluble therein, the mean particle size of such micronized particles ranging from 0.01 to 2 .mu.m and (d) optionally, at least one crosslinked polymer of at least one ethylenically unsaturated monomer.

- Cosmetic and/or dermatological powder, process for its preparation and its uses

A cosmetic and/or dermatological powder comprising from 5 to 70% of modified starch and from 30 to 95% of oily phase comprising at least one oil. The present invention also relates to a process for manufacturing a cosmetic and/or dermatological powder comprising at least one modified starch and an oily phase, by (1) preparing an oil-in-water dispersion by mixing an oily phase comprising at least one oil in an aqueous phase comprising at least one modified starch, the oily phase/starch weight ratio ranging from 3:7 to 19:1, and (2) dehydrating the dispersion in order to obtain the powder. The powder may be used just as it is and is useful in particular to care for, cleanse, remove make-up from, make up and/or treat the skin, mucous membranes and/or the scalp.

- Modified protease having 5 to 13 covalently coupled polymeric molecules for skin care

Modified enzymes are prepared for use in skin care products by covalently coupling to the enzymes from 4 to 70 polymeric molecules with or without a linker such as a triazine ring. Molecular weight of the polymeric molecules may be from 1 to 35 kDa and of the enzymes from 15 to 100 kDa. The number and weight of polymeric molecules coupled is balanced with the weight and/or surface area of the enzymes. Enzymes include proteases such as subtilisins, lipases and oxidoreductases such as laccases and superoxide dismutase, and polymeric molecules include polysaccharides such as dextran or pullulan and polyalkylene oxides such as polyethylene glycol. The polymeric molecules may be coupled to the enzymes at the N-terminal amino group and/or lysine residues, and preferably at a position more than 5 .ANG. from the active site of the enzymes. A preferred modified enzyme is a protease having from 5 to 13 coupled polymeric molecules. Skin care products containing the modified enzymes have improved stability and reduced allergenicity as compared to the products containing the unmodified enzymes.

- Use of peroxidized lipids as agents intended to prevent and/or to treat the irritant effects of an active principle

A composition for topical application to the skin, contains an active principle with irritant character in a cosmetically or pharmaceutically acceptable vehicle, in which the vehicle contains more than 5% by weight of peroxidized vegetable oil having a peroxidation level of between 5 and 600 milliequivalents per kg. The presence of the peroxidized oil reduces the irritant character of the principle, particularly capsaicin and retinoic acid.

- COSMETIC AND/OR DERMATOLOGICAL COMPOSITION CONSISTING OF AN EMULSION OF THE OIL-IN-WATER TYPE FORMED FROM LIPID VESICLES DISPERSED IN AN AQUEOUS PHASE CONTAINING AT LEAST ONE HYDROPHILIC ACIDIC ACTIVE AGENT

A composition for topical use, comprising an oil-in-water emulsion formed from lipid vesicles consisting of oily globules, each having a lamellar liquid crystal coating obtained from at least one surfactant, dispersed in an aqueous phase containing at least one hydrophilic acidic active agent but which does not contain a gelling agent.

- Arylalkanoylpyridazines

Arylalkanoylpyridazine derivatives of the formula I ##STR1## and their physiologically acceptable salts and solvates, in which R.sup.1, R.sup.2, Q and B have the meanings indicated in Claim 1, show an inhibition of phosphodiesterase IV and can be employed for the treatment of asthma, chronic bronchitis, atopic dermatitis, psoriasis and other skin diseases, inflammatory diseases, autoimmune disorders, such as, for example, rheumatoid arthritis, multiple sclerosis, Crohn's disease, diabetes mellitus or ulcerative colitis, osteoporosis, transplant rejection reactions, cachexia, tumor growth or tumor metastases, sepsis, memory disorders, atherosclerosis and AIDS.

- Skin whiteners containing hydroxytetronic acid

Skin whitening compositions contain .alpha.-hydroxytetronic acid or a .alpha.-hydroxy tetronic derivative, and, in some cases, hydroquinone, an .alpha.-hydroxy acid such as glycolic acid, and a fatty acid ester of ascorbic acid such as ascorbyl palmitate.

- Active topical skin protectants using hybrid organic polysilsesquioxane materials

A topical skin protectant formulation containing a barrier cream and an active hybrid organic-inorganic polysilsesquioxane material for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.

- Irradiation enhanced permeation and delivery

The present invention provides a method of delivering substances for permeation through the skin of a subject, by energizing the stratum corneum in conjunction with various delivery means including gels and patches. Permeability enhancement or reduced electrical impedance of the skin, increases the variety of substances capable of permeation, and increases the permeation rate and the effectiveness of the permeation, including permeation enhanced by iontophoresis. The method allows for the use of improved delivery means that were previously unavailable.

- Hypoallergenic make-up or care composition comprising a crosslinked organopolysiloxane comprising an oxyalkylene group, and its uses

A hypoallergenic composition for making up or caring for keratinous substances which comprises an aqueous phase dispersed in a liquid fatty phase by means of particles of crosslinked elastomeric solid organopolysiloxane comprising at least one oxyalkylene group and in particular an oxyethylene group, the said composition additionally being devoid of cosurfactant. The invention also relates to the use of these particles of elastomeric solid organopolysiloxane in a hypoallergenic and fresh cosmetic composition or for the manufacture of a hypoallergenic and fresh care, treatment or make-up composition, comprising an aqueous phase dispersed in a liquid fatty phase.

- Cosmetic skin treatment method and cleansing treatment patch

A cosmetic skin treatment method includes providing a patch configured to be used in both a cleansing mode and a treatment mode. The patch includes a polymeric matrix and a reinforcing member. The polymeric matrix includes at least one cosmetically active compound and at least one water-absorbent compound. The patch is configured to adhere to dry skin and also to adhere to skin when at least one of the patch and skin are moistened. The method also includes selecting at least one of the cleansing mode and the treatment mode. When the cleansing mode is selected, the method further includes applying the patch to an areas of dry skin so that the polymeric matrix adheres to the skin for a time sufficient to allow at least one impurity in the area of skin to become attached to the polymeric matrix. Thereafter, the patch is removed from the area of the skin while said at least one impurity is attached to the polymeric matrix. When the treatment mode is selected, the method further includes moistening at least one of the patch and an area of the skin. Then, the patch is applied to the area of skin so that the patch adheres to the area of skin. After applying the patch, the cosmetically active compound is allowed to contact the area of skin. A cleansing and treatment patch is also disclosed.

- Nanoemulsion based on mixed esters of a fatty acid or of a fatty alcohol, of a carboxylic acid and of a glycerol and its uses in the cosmetics, dermatological and/or ophthalmological fields

A nanoemulsion, the oil globules of which have a number-average size of less than 100 nm, comprising a surfactant chosen from mixed esters of a fatty acid or of a fatty alcohol, of a carboxylic acid and of glycerol and at least one oil having a molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The nanoemulsion may be used in, for example, the cosmetics and dermatological fields, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and in the ophthalmological field, as an eye lotion for treating the eyes.

- Active topical skin protectants using polyoxometallates

A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.

- Cosmetic and dermatological preparations with flavonoids

The invention relates to cosmetic and dermatological formulations having a) a content of a compound or several compounds from the group consisting of flavonoids, or having b) a content of an active compound combination comprising a compound or several compounds chosen from the group consisting of flavonoids in combination with a compound or several compounds chosen from the group consisting of cinnamic acid derivatives and c) if appropriate an additional content of a compound or several compounds from the group consisting of antioxidants.

- Aminophenol derivatives and their use in cosmetics

Use of at least one aminophenol derivative of formula (I) below: ##STR1## in which: R represents a hydrogen atom or a radical --COR.sub.2, wherein R.sub.2 represents a saturated or unsaturated, linear, cyclic or branched, optionally hydroxylated, C.sub.1 to C.sub.30 hydrocarbon or alkoxy radical; R.sub.1 is a radical of formula (a), (b) or (c) below: (a) --CO--NR.sub.3 R.sub.4 (b) --CO--O--R.sub.5 (c) --SO.sub.2 --R.sub.5 wherein R.sub.3 represents a hydrogen atom or a linear or branched, saturated or unsaturated, optionally hydroxylated, C.sub.1 to C.sub.6 hydrocarbon radical, R.sub.4 represents a hydrogen atom or a saturated or unsaturated, linear, cyclic or branched, optionally hydroxylated, C.sub.1 to C.sub.30 hydrocarbon radical, and R.sub.5 represents a saturated or unsaturated, linear, cyclic or branched, optionally hydroxylated, C.sub.1 to C.sub.30 hydrocarbon radical, in a depigmenting and/or bleaching cosmetic composition for human skin, body hairs or head hair; compositions comprising the derivatives of formula (I) and a process for depigmenting and/or bleaching the skin, body hairs and/or head hairs.

- Polysaccharide sponges for cell culture and transplantation

A polysaccharide sponge characterized by having: (i) an average pore size in the range between about 10 .mu.m to about 300 .mu.m; (ii) an average distance between the pores being the wall thickness of the pores in the range between about 5 .mu.m to about 270 .mu.m; and (iii) an E-modulus of elasticity being a measure of the rigidity of the sponge in the range of about 50 kPa to about 500 kPa.

- Cosmetic compositions

A cosmetic composition is a structured emulsion of a continuous phase containing water-immiscible liquid carrier plus a structurant, and a disperse phase which is a solution of antiperspirant active in a more polar, probably aqueous, solvent. The structurant is a material which forms a network of fibers in the continuous phase, thereby gelling it. The structurant has an enthalpy of gelation in the carrier liquid or a test liquid with a magnitude of at least 30 kJ/mole. This minimum enthalpy of gelation facilitates processing at conveniently accessible temperatures and promotes stability.

- Water-in-oil emulsion, composition comprising such an emulsion, and use thereof

The present invention relates to a stable water-in-oil emulsion for cosmetic, pharmaceutical or hygiene use, comprising an aqueous phase and a fatty phase comprising a silicone oil, characterized in that it comprises an emulsifying system comprising at least one .alpha.,.omega.-substituted oxyalkylenated silicone of formula (I): ##STR1## in which: R=--(CH.sub.2).sub.p O--(C.sub.2 H.sub.4 O).sub.x (C.sub.3 H.sub.6 O).sub.y R.sup.1 where: R.sup.1 represents H, CH.sub.3 or CH.sub.2 CH.sub.3, p is an integer ranging from 1 to 5, x ranges from 1 to 100 and y ranges from 1 to 50, it being possible for the units (C.sub.2 H.sub.4 O) and (C.sub.3 H.sub.6 O) to be distributed randomly or in blocks, the R.sup.2 radicals represent a C.sub.1 -C.sub.3 alkyl radical or a phenyl radical, 5.ltoreq.m.ltoreq.300, and a co-surfactant chosen from the family of glycol mono- and/or diesters and glyceryl mono-, di- and/or triesters, and mixtures thereof. The invention also relates to a composition comprising the above emulsion, and to its applications in the cosmetics, pharmaceutical, dermatological or hygiene fields.

- Cosmetic preparation of active substances with high protection factor against free radicals

The disclosed cosmetic preparation of active substances protects the skin in a particularly effective way against free radical aggression, both alone and in combination with other active substances. The preparation consists of a Quebraco blanco bark extract containing at least 90 wt. % proanthocyanidin oligomers, a silkworm extract containing the peptide cecropin, amino acids and a vitamin mixture, a non-ionic, cationic or anionic hydrogel, phospholipids and water, and may also contain further active substances such as vitamin derivatives and plant extracts of acerola, sea weed, citrus, bitter orange, cherry, papaya, tea, coffee beans, Mimosa tenuiflora and angelica. The preparations have protection factors against free radicals of up to 10000, and the cosmetic compositions containing these preparations have protection factors of between 40 and 200, depending on their proportion of the preparations.

- Substantive water-soluble bis-quaternary salts of cinnamidoalkylamines

Substantive UV-absorbing water-soluble quaternary salts of cinnamidoalkylamine of formula I. Hair, skin and fabric care compositions containing the compounds of formula I; ##STR1## wherein R.sub.1 represents up to four substituents, same or different, selected from H, halo, --OH, --NH.sub.2, --NO.sub.2, --OCH.sub.3, --N(CH.sub.3).sub.2, alkyl groups containing up to 6 carbon atoms, alkoxy groups containing up to 6 carbon atoms, alkylamino or N,N-dialkylamino groups containing up to 6 carbon atoms; R.sub.2 is selected from hydrogen, alkyl group containing up to 6 carbon atoms; R.sub.3 and R.sub.4 are independently selected from benzyl, alkyl group containing up to 6 carbon atoms; n is an integer from 1 to 6; m is an integer from 1 to 10; X.sup.- is a counter anion of quaternary centres selected from halides including chloride, bromide, iodide and methane sulphonate and its derivatives such as trifluoro methane sulphonate, benzene sulphonates including its p-bromo, nitro and methyl derivative.

- Aqueous cosmetic preparations in stick form

A cosmetic composition containing: (a) an alkyl and/or alkenyl oligoglycoside corresponding to formula (I): wherein R.sup.1 is an alkyl and/or alkenyl radical having from 4 to 22 carbon atoms, G is a sugar radical having 5 or 6 carbon atoms, and p is a number from 1 to 10; (b) an oily compound; (c) a nonionic emulsifier; and (d) an active ingredient selected from the group consisting of an anti-perspirant compound, a deodorant compound, an antibacterial active compound, and mixtures thereof, and wherein the composition is free of soap and natural wax.

- Bioadhesive nanoparticulate compositions having cationic surface stabilizers

Bioadhesive nanoparticulate compositions, comprising active agent particles and one or more cationic surface stabilizers, are described. The cationic surface stabilizers prevent aggregation of the nanoparticles and increase bioadhesion of the nanoparticles to biological substrates, such as an insect, teeth, bone, nails, chitin, feathers, scales, mucous, skin, hair, plant tissue, etc. The particles may consist of pharmacologically active compounds (e.g., drug compounds for human or veterinary use), agricultural chemicals (pesticides, herbicides, fertilizers, and the like), cosmetic agents, consumer products (coloring agents, flavors, or fragrances), or other materials which function by interacting with biological substrates. In addition, the invention relates to methods of preparing and using such bioadhesive nanoparticulate compositions.

- Use of taurolidine to treat tumors

The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.

- Foam, an interior material made of the foam, a molded article destined for an interior vehicular material, and production methods thereof

The object is to obtain a foam, an interior material, and a molded article destined for an interior automotive or other vehicular material which can inhibit the formation of crystals in the fogging test. The present invention is a foam, an interior material and a molded article destined for an interior vehicular material, comprising a fogging inhibitor, to keep the amount of the precipitate detected by the fogging test at 0.8 mg or less. The foam and the interior material obtained according to the present invention can be suitably used as a dash board in front of the driver's seat, an interior material at the door and as an interior material of the ceiling in an automobile.

- Antigenic protein originating in malassezia

A substantially pure, isolated, antigenic protein from fungi of the genus Malassezia, characterized in that said antigenic protein has a binding ability to IgE antibodies from patients with allergoses; an antigenic fragment derived from the antigenic protein; and an antibody against the antigenic protein or fragments thereof. According to the present invention, there can be provided an isolated and purified antigenic protein having high purity from Malassezia, antigenic fragments thereof, and a specific antibody against those antigenic protein or fragments thereof. In addition, there can be provided a diagnostic agent, a therapeutic agent, or a prophylactic drug for Malassezia allergoses, wherein the agent includes, as an active ingredient, the antigenic protein or fragments thereof.

- Emollient compositions with polyethylene beads

An emollient composition comprising at least 5-30% by weight polyethylene, 0-60% by weight petrolatum, and 0-50% octyl palmitate. These emollient compositions may be used as emollient carriers for various materials, such as fragrances and pigments or dyes, to be externally applied to the skin. These emollient compositions may be formed into particulate shapes, such as spheres, for subsequent use in cosmetic products.

- Use of hyperbranched polymers and dendrimers comprising a particular group as film-forming agent, film-forming compositions comprising same and use particularly in cosmetics and pharmaceutics

The invention concerns the use of hyperbranched polymers and dendrimers, comprising at least one group of formula (I) in which: Y represents the oxygen atom or a NH group: and A represents a C.sub.1 -C.sub.12 alkane di-yl group, linear, branched or cyclic, saturated or unsaturated; said group being optionally interrupted by one or several heteroatoms and/or substituted by a function selected among: amino (--NH.sub.2): acylamino (--NH--CO--R) in which R represents a C.sub.1 -C.sub.10 alkyl group, linear, branched or cyclic, saturated or unsaturated; carboxylic acid (--COOH), ester (--COOR) in which R represents a C.sub.1 -C.sub.10 alkyl group, linear, branched or cyclic, saturated or unsaturated, as film-forming agent. The invention also concerns a film-forming composition comprising said compound and its use particularly in cosmetics or pharmaceutics.

- Dry emollient composition composing mono-unsaturated jojoba esters

Disclosed are dry-feel emollient compositions comprising fatty alcohols, alkyl esters and jojoba wax esters obtained by a novel process of a base catalyzed alcoholysis reaction between jojoba oil and an alcohol, such as isopropyl alcohol. The composition is essentially solid at room temperature, can be provided in various shapes and sizes (especially as particulates such as spheres). These new compositions increase the range of applications for cosmetic compositions by providing an emollient that is more polar and hydrophilic than is found in naturally occurring jojoba oils (jojoba wax esters). These compositions have use in personal care, cosmetic, cosemceutical and pharmaceutical products. Typical materials these compositions may be blended include, but are not limited to, cosmetic oils and waxes, both natural and synthetic, hydrogenated or partially hydrogenated oils, silicone oils, mineral oils, long chain esters, vitamins, long chain fatty acids, alcohols, cosmeceuticals, pigments, botanical extracts, esters and ethers, dimers, trimers, oligomers, polymers, and the like. These compositions may be combined with active ingredients to be delivered by the compositions.

- Film coated microbeads containing active compounds and method of making the same

Disclosed is a composition for use in dermal application. The composition includes microbeads or chemically stable particles having an internal structure of pores. A chemical compound having a pharmaceutical or cosmetic activity is retained in the internal structure of the porous particles. Each of the particles is coated with at least one of a silicone and a polysiloxane-based compound. Also disclosed is a method of making a composition. A plurality of particles containing a chemical compound in its internal structure is prepared. A coating mixture including at least one of a silicone and a polysiloxane-based compound with a solvent is also prepared. The particles are mixed with the coating mixture, which coats over the particles. The coated particles are subject to drying to evaporate the solvent from the coating mixture.

- Decorative components having an elastomeric outer surface and methods of making such components

The aromatic polyurethane elastomers of the present invention are particularly suited for methods of making objects in a mold cavity. The objects generally include an elastomeric layer formed from an aromatic polyurethane and a foam layer which is subsequently applied to the elastomer. The aromatic elastomer of the present invention lends itself to being precoated with an in-mold coating or being painted after demolding the resulting part.

- Piperazine derivative

A piperazine compound represented by formula (1): ##STR1## wherein X is --CH.sub.2 --, --C(O)-- or --CH(CH.sub.3)--; R.sup.1 is a hydrogen atom or alkyl group; and R.sup.2 is a hydrogen atom, alkyl group, hydroxyalkyl group, arylalkyl group, heteroarylalkyl group, carboxyalkyl group, carboxamidoalkyl group, aminoalkyl group or guanidinoalkyl group; an acid-addition salt thereof, or a hydrate thereof. The compound has excellent inhibitory effects on both cell adhesion and cell infiltration and is useful for prevention or treatment of diseases such as allergy, asthma, rheumatism, arteriosclerosis and inflammation.

- Benzophenones as inhibitors of IL-1.beta. and TNF-.alpha.

Heteroaryl aminobenzophenones of general formula I inhibit interleukin-1.beta. and TNF-.alpha. and may therefore be useful in the therapy of inflammatory diseases and conditions.

- Amphiphilic polyamine compounds

In accordance with the present invention, there are provided amphiphilic polyamine compounds and derivatives thereof having the property of promoting transfection of polynucleotides and polypeptides into cells, and formulations comprising said compounds.

- Method for retarding and preventing sunburn by UV light

Astaxanthin is a potent antioxidant, over 500 times more powerful than Vitamin E and 10 times stronger than other carotenoids such as zeaxanthin, lutein, canthaxanthin and beta-carotene. Astaxanthin has also been shown to enhance and modulate the immune system. Disclosed is a method and treatment for retarding and preventing sunburns. The method comprises administering a source of astaxanthin in a therapeutically effective amount to prevent and retard sunburns.

- Composition

A composition comprising a cream or lotion base said base further comprising a. An active agent or mixture thereof which brings about skin lightening, and b. An active agent or mixture thereof which prevents skin from further darkening when exposed to ultraviolet light.

- Emollient for cuticle treatment and delivery system therefore

A product for treating and conditioning cuticles using a semi-solid emollient and a complimentary delivery system is disclosed. The emollient could be any semi-solid emollient suitable for cuticle treatment, the emollient preferably including naturally derived botanicals that impart a "dry" feel, and a soothing and softening effect on the cuticle area. Isopropyl jojoba (IPJ) and hydrogenated isopropyl jojoba (HIPJ) esters, hydrogenated jojoba alcohol, jojoba esters, hydrogenated jojoba oil, ethyl macadamiate and other esters, waxes and oils may be used in the emollient to contribute to the "dry" feel and serve as carriers for active materials used to treat cuticles. The semi-solid emollient is retained in a container, preferably in stick form, and is extendable from and preferably retractable into the container, which can be carried by an individual. The container is designed to enable a user to apply the emollient to a cuticle area without touching the emollient with his/her fingertips, thereby preventing application or migration of the emollient to unselected areas.

- Use of a hybrid polymeric material for coating keratinous materials

The invention relates to the use, for coating keratin substances, of a crosslinked hybrid polymer material which can be obtained from an aqueous solution containing: (a) at least one water-soluble polymer containing at least functional groups capable of forming hydrogen bonds, and (b) at least one organic or inorganic salt, of ammonium or of a monovalent or polyvalent metal cation; and by physical crosslinking of the said polymer resulting from hydrogen interactions between the functional groups of the said polymer and the water molecules in the hydration sphere of the said hydrated cation, for the preparation of cosmetic or dermatological compositions. The invention relates more particularly to the use of the said coating agent for make-up products, in particular foundations, lipsticks, mascaras, eyeliners and care bases for the nails; for hair formulations, in particular styling products and/or products for holding the hair, or alternatively for skincare products.

- Transdermal or topical plaster system with a polyacrylate matrix with improved physical properties

A transdermal or topical plaster system with a backing layer, with an active ingredient-containing and self-adhesive matrix based on crosslinkable polyacrylate as base polymer and with a removable protecting film is characterized by an at least two-layer matrix with a degree of crosslinking of the layer facing the skin which is appropriate for adequate adhesion to the skin thereof and is lower than the degree of crosslinking of the layer or layers on top thereof.

- Antimicrobial cleansing compositions containing 2-pyrrolidone-5-carboxylic acid

Disclosed are antimicrobial cleansing compositions that have a pH of from about 2.0 to about 5.5 and comprise an antimicrobial agent, an amphoteric sulfactant, and 2-pyrrolidone-5 carboxylic acid as a proton donating agent. Also disclosed are corresponding articles of manufacture and methods of cleansing the skin using the described compositions. The compositions are mild to the skin and provide improved antimicrobial benefits to the skin.

- Compositions and methods for treating superficial fungal infections

Compositions comprising 4,4'-methylenebis(tetrahydro-1,2,4-thiadiazine) 1,1,1',1',-tetraoxide and their use in treating dermatologic disorders are disclosed.

- Agent for preventing and treating skin diseases

The present invention relates to an agent for preventing and treating skin diseases comprising as an active ingredient an ascorbic acid derivative which is a compound represented by the following formula (1) or a salt thereof and which per se exhibits no anti-oxidation activity but is capable of transforming in vivo into a compound having an anti-oxidation activity; ##STR1## wherein R.sup.1 represents a group capable of bonding to the carbon at the 2-position of the ascorbic acid skeleton through an ether or ester bond and transformable in vivo into a hydroxyl group, and R.sup.2 to R.sup.4 may be the same or different and each represents a hydroxyl group or a group derived therefrom.

- Active topical skin protectants using polymer coated metal alloys

A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWAs). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.

- W/O emulsion composition comprising such an mulsion and cosmetic pharmaceutical or hygiene use thereof

The present invention relates to a stable water-in-oil emulsion for cosmetic, pharmaceutical or hygiene use, comprising an aqueous phase and a fatty phase comprising a silicone oil, characterized in that it comprises at least one .alpha.,.omega.-substituted oxyalkylenated silicone, the emulsion having a viscosity ranging from 100 cps to 200 poises, at 25.degree. C. and at a shear rate of 200 s.sup.-1. The invention also relates to the compositions comprising such an emulsion, and to its applications in the cosmetics field.

- Transdermal systems for release of 5-HT3 receptor antagonists and their use in anti-emetic treatment

This invention refers to a transdermal system for release of 5-HT.sub.3 receptor antagonists which is characterized in that it contains a composition of a 5-HT.sub.3 receptor antagonist as an active agent, tea tree oil, a water-miscible solvent and water.

- Photomatrix device

A device for the physiotherapeutic irradiation of spatially extensive pathologies by light with the help of a matrix of the sources of optical radiation such as lasers or light diodes placed on the surface of a substrate whose shape is adequate to the shape of the zone of pathology is disclosed. In addition, the device contains stops and a holder to fix the substrate against the bioobject. Additional modules are provided to adjust the temperature, pressure, gas composition over the pathological area. As a source of radiation, chemical reactions accompanied by the luminescence of the products of reaction are suggested. The power supply unit can be autonomous with remote feeding through pulse magnetic field. A supplementary hood optically transparent is provided to localize the pathology as well as the strips that scatter the radiation to get a more uniform bioobject's exposure. Application: light-therapy to treat various extensive pathologies on the bioobject's surface including dermatology, cosmetology; the treatment of traumas, bruises, oedemas, varicose veins, blood therapy, treatment of infectious processes.

- Sunscreen compositions containing a dibenzoylmethane derivative

The present invention relates to a method of photostabilizing a composition comprising (a) one or more dibenzoylmethane derivative UV-A absorbing agent(s); (b) one or more benzophenone derivative(s); and (c) a diester or polyester of a naphthalene dicarboxylic acid and a method of protecting mammalian skin or hair from UV radiation comprising topically applying to the skin or hair such a composition.

- Cosmetics with hydrofluoroether (HFE)

A cosmetic containing at least 1% by weight of hydrofluoroether having a viscosity of less than 5 mPa.multidot.s at 25.degree. C., which is represented by the general formula (1): wherein n is a number of 1 to 12, m is a number of 0 to 25, l is a number of 0 to 11, m+l=2n+1, x is a number of 1 to 12, y is a number of 0 to 25, z is a number of 0 to 11, and y+z=2x+1, provided that m and y are not be simultaneously zero, and l and z are not be simultaneously zero, gives no environment disruption, is highly safe for the skin and improves the feeling in use.

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US: 6444647

- Skin care compositions containing combination of skin care actives

The present invention relates to skin care compositions containing combinations of skin care actives and to methods of using such compositions to regulate the condition of skin. The compositions contain a safe and effective amount of a vitamin B3 compound; a safe and effective amount of a skin care active selected from farnesol, phytantriol, and mixtures thereof; and a dermatologically acceptable carrier.

- Use in cosmetics of a rigid gel, and cosmetic or dermatological compositions used

The present invention relates to the use in cosmetics of rigid gels containing at least 20% by weight of one or more water-soluble or hydrophilic gelling agent(s) which may be obtained from the said water-soluble or hydrophilic gelling agent in the presence of water by mixing, blending, compression and extrusion in a twin-screw extruder. These gels constitute novel pharmaceutical forms for cosmetic or dermatological use. These gels are generally in the form of sticks, pencils or cakes. They may be aqueous with a matrix consisting of an aqueous gelled network. They may be in anhydrous form with a matrix consisting of a dehydrated gelled network. They may constitute many products in solid form applied to making up, to care of and/or to treatment of the skin, the scalp, the hair or the mucous membranes, or alternatively applied to the hygiene of the body, the skin, the scalp, the hair or the mucous membranes.

- Zwitterionic-fatty acid compounds having anti-inflammatory properties

A composition and method for treating both superficial and subdermal inflammation is taught by treating an inflamed skin area, muscle, or bone joint, with a therapeutically effective amount of a skin-compatible ester of a zwitterionic aminosulphonic acid (ZASA-Ester) of the formula. A pharmacologic composition is also provided which comprises at least one amphoteric (Zwitterionic-ester) with a pharmacologically-acceptable topical carrier or base. Other adjunctive pharmaceutical agents may be included to facilitate other than topical administration. Also useful are analogs of HEPES/EPES, like Piperazine-N'(2-ethanesulfonic acid; N-Methylpiperazine -N.sup.1 (2-ethanesulfonic acid) and the piperidine analog of the piperazine ester.

- Combination of erythrulose and a reducing sugar with self-tanning properties

The invention relates to an active ingredient combination containing erythrulose and a further reducing sugar with self-tanning properties, for example, dihydroxyacetone, which combination is used for artificially tanning the skin. Compared with compounds containing, for example, only dihydroxyacetone, said active ingredient combination and cosmetic compounds based thereon result in an even and longer-lasting colouring of the skin and prevent skin dehydration and uneven flaking.

- Method and makeup kit containing goniochromatic and monochromatic pigments

The present invention relates to a new makeup kit comprising a first, goniochromatic pigment composition which is intended to form a base layer and a second, conventional pigment composition having one of the colors of the first pigment, the second composition being intended to form a surface layer comprising decorative motifs. Depending on the viewing angle, therefore, it is possible to see the said motifs appear or disappear. This kit is intended in particular for making up the nails, lips, cheeks or eyelids, or else the body. The invention also relates to a method of making up the human face, lips or body.

- Mild, rinse-off antimicrobial liquid cleansing compositions

The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.1% to about 5.0%, by weight of the cleansing composition, of an antimicrobial active; from about 9% to about 14%, by weight of the cleansing composition, of an anionic surfactant, wherein at least about 67% of the anionic surfactant is selected from the group consisting of Class A surfactants, Class C surfactants, and mixtures thereof, wherein the ratio of Class A surfactant to Class C is from about 4:1 to about 1.5:1, and wherein the total anionic surfactant comprises less than about 50% of the ammonium counter cation salt; from about 4% to about 8%, by weight of the cleansing composition, of a proton donating agent having a Biological Activity Index, Z, of greater than about 0.75 and wherein the proton donating agent is such that the composition is essentially free of C.sub.4 -C.sub.20 alkyl fatty acid; a mildness enhancing agent selected from the group consisting of from about 20% to about 70%, by weight of the anionic surfactant, of a mildness enhancing cosurfactant; form about 0.1% to about 1.0%, by weight of the cleansing composition, of a mildness enhancing polymer; and mixtures thereof; and from about 35% to about 93.9%, by weight of the cleansing composition, of water; wherein the composition is adjusted to a pH of greater than about 3.5 and less than about 4.5. The invention also encompasses methods for cleansing, removing germs and decreasing the spread of transient Gram negative and Gram positive bacteria using the rinse-off antimicrobial cleansing compositions described herein.

- Chitosan formulation with azelaic acid and other actives for the treatment of acne

A composition for treating acneiform eruption containing: (a) a chitosan having a molecular weight ranging from about 500,000 to about 5,000,000 g/mole and a degree of deacylation greater than 80%; (b) an acid-form active ingredient for treating acne; and (c) water.

- Cosmetic compositions

A cosmetic composition contains a water-immiscible carrier liquid and a structurant therefor which is effective to gel the composition upon cooling from a temperature at which the structurant is a mobile solution in the carrier liquid. The carrier liquid may serve as a continuous phase in which a solid or liquid disperse phase is suspended. The structurant is a fully or partially esterified saccharide which contains no more than eight monosaccharide residues and has an enthalpy of gelation in the carrier liquid with a magnitude of at least 45 kJ/mole. This minimum enthalpy of gelation facilitates processing at conveniently accessible temperatures and promotes stability.

- Cosmetic compositions

The sensory attributes and/or visibility of deposits of wax-structured antiperspirant or deodorant sticks in the form of emulsions can vary significantly depending on the formulation employed. A particularly beneficial balance of attributes is obtained in emulsion sticks by employing a composition comprising a continuous phase which comprises from 10 to 35% volatile silicone oil, and from 5 to 15% non-volatile hydrophobic oil, from 40 to 75% of ta disperse aqueous phase which contains from 1 to 35% of an antiperspirant or deodorant active, from 7 to 25% of a wax structurant, from 0.1 to 10% of an emulsifier, and preferably contains up to 5% insoluble particulate materials, %s being by weight based on the composition.

- Cosmetic composition and a method for the prevention and/or reduction of the photoaging processes of the skin

A novel cosmetic composition comprising a known hydroximic acid derivative as the active ingredient, and conventional carriers of the cosmetic composition are disclosed. The cosmetic composition of the invention is suitable for the prevention and/or reduction of the photoaging processes of the skin exposed to UV radiation.

- Water hardenable compositions for splints and braces

An orthopaedic support (50) or product is formed of a doubleknit type fabric material with spaced interwoven layers formed of high strength materials, and an open-work matrix of filaments or threads interconnecting the layers. The fabric may be impregnated with water hardened urethane. Hydroxy propyl methyl-cellulose (HPMC) will also be applied to the doubleknit type material or other casting fabric in sufficient amount to reduce the stickiness of the water hardened urethane. The HPMC may be mixed in with the water surfaces of the doubleknit type material. The orthopaedic support (50) or product is packaged in a water-vapor impermeable package; and is opened. Water is supplied to the fabric when it is applied to the part of the anatomy requiring support. The fabric may be included in a soft goods' support including a water distribution network, and straps (74) to hold the support in place.

- Method of treating hair or skin

A cosmetic consists of a cosmetic raw material in the form of an emulsion of silicone or organic oil containing crosslinked particles mixed with other cosmetic raw materials. Its touch on fingers and skin is good, spreading and feel during use are good, and it can also prevent unruly hair, stray hair, and tangling of hair, so hair can easily be arranged. It imparts a fresh, dry feeling without any stickiness. The cosmetic raw material consists of the silicone or organic oil emulsion containing crosslinked particles with a mean particle diameter of 0.05 to 100 .mu.m. Crosslinking is obtained by an hydrosilylation of liquid crosslinkable compositions consisting of (A) organic compounds with at least two aliphatic unsaturated bonds per molecule, (B) silicon containing organic compounds with at least two hydrogen atoms bonded to silicon atoms in each molecule, and (C) hydrosilylation reaction catalysts. The resulting crosslinked particles are contained in the droplets of the silicone oil or the organic oil which have mean particle sizes of 0.1 to 500 .mu.m, and which droplets are in turn dispersed in water.

- Skin-protective composition

The present invention relates to a protective composition for skin, which protects against bacterial, viral and fungal infections. The compositions comprise a C.sub.8 -C.sub.20 fatty acid, one or more parabens or a combination of these. The compositions of the invention are particularly effective in controlling infections by Methicillin Resistant Staphylococcus aureus (MRSA) as well as other organisms. The invention includes protective hand creams such as barrier hand creams, as well as body lotions, liquid soaps, shampoos, soap bars and creams generally, which are all protective.

- Nanoemulsion based on alkoxylated alkenyl succinates or alkoxylated alkenyl succinates of glucose and its uses in the cosmetics, dermatological, opthalmological and/or pharmaceutical fields

A nanoemulsion, the oil globules of which have an average size of less than 100 nm, comprising a surfactant chosen from the alkoxylated alkenyl succinates, the alkoxylated alkenyl succinates of glucose and the alkoxylated alkenyl succinates of methylglucose, and at least one oil having a molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The emulsion obtained is transparent and stable on storage. It can comprise large amounts of oil while retaining good transparency and while having good cosmetic properties. It can constitute a composition for topical use, a pharmaceutical composition or an ophthalmological composition.

- Biodegradable polymer composition

A flowable composition containing a biocompatible, biodegradable, branched thermoplastic polymer is used to form solid matrices such as implants and controlled-release, drug-compositions in a body. The flowable composition with or without bioactive agent can be administered by syringe and needle to form in situ a solid matrix. Alternatively, the flowable composition can be used to form ex vivo solid biodegradable matrices such as articles, implants and devices. The articles implants and the like can then used as solid fasteners, prosthetic devices, and controlled drug compositions.

- Anesthetizing plastics, drug delivery plastics, and related medical products, systems and methods

Anesthetizing plastic or other drug delivery polymer system including a hydrophobic polymer and a drug that has an aromatic ring.

- Fluorescent whitening agents

The present invention provides new compounds having the formula: ##STR1## in which X is O or, preferably, NH; M is hydrogen, an alkali metal atom, ammonium or a cation formed from an amine; each R.sub.1, independently, is an aminoacid residue from which a hydrogen atom on the amino group has been removed; n is 1 or 2; and each R.sub.2, independently, is hydrogen, C.sub.1 -C.sub.3 alkyl, halogen, cyano, COOR in which R is hydrogen or C.sub.1 -C.sub.3 alkyl, CONH--R in which R has its previous significance, SO.sub.2 NH--R in which R has its previous significance, NH--COR in which R has its previous significance, SO.sub.3 M in which M has its previous significance or, when n is 1, R.sub.2 can also be CO--R.sub.3 in which R.sub.3 is C.sub.1 -C.sub.3 alkyl or phenyl; provided that those compounds are excluded in which a) X is NH, n is 1 and R.sub.2 is SO.sub.3 M in which M has its previous significance; or b) X is NH, n is 2 and one R.sub.2 is SO.sub.3 M in which M has its previous significance, and the other R.sub.2 is hydrogen, methyl or halogen; or c) X is NH, n is 1, R.sub.1 is glycine and R.sub.2 is H or CO.sub.2 H; or d) X is NH, n is 2, each R.sub.2 is SO.sub.3 M in which M has its previous significance and the SO.sub.3 M groups are in 2,5-positions in the phenyl ring and R.sub.1 is D,L-alanine, L-valine, L-leucine, L-isoleucine, L-threonine, L-aspartic acid, L-glutamic acid, L-phenylalanine, L-proline, (),L- or glycine. Most of the new class of 4,4'-diaminostilbene-2,2'-disulfonic acid compounds are useful as fluorescent whitening agents, especially for paper.

- Nanoemulsion based on ethylene oxide and propylene oxide block copolymers and its uses in the cosmetics, dermatological and/or ophthalmological fields

A nanoemulsion comprising an oily phase dispersed in an aqueous phase and having oil globules with a number-average size of less than 100 mm, which dispersion is facilitated by a surfactant comprised of polyethylene oxide and polypropylene oxide blocks, the oily phase comprising at least one oil having a molecular weight of greater than 400 and wherein the ratio by weight of the amount of oily phase to the amount of surfactant ranges from 2 to 10.

- Inhibition of crystallization in transdermal devices

A steroid is used as an additive in manufacture of a transdermal drug delivery device, to act as a crystallization inhibitor inhibiting crystallization, during storage of the device, of an active drug in the form of a hormone which has a pharmaceutical or physiological effect in use of the device. The crystallization-inhibiting steroid is present in the device in an amount insufficient to provide significant pharmaceutical or physiological effect in use of the device.

- Method for facilitating absorption of pharmaceutically active compounds

Methods and apparatus for improving administration of drugs through the use of heat and other physical means. The present invention relates to the use of heat and other physical means in conjunction with specially designed dermal drug delivery systems, conventional commercial dermal drug delivery systems, or drugs delivered into a sub-skin depot site via injection and other methods to alter, mainly increase, the drug release rate from the dermal drug delivery systems or the depot sites to accommodate certain clinical needs.

- Composition in the form of an oil-in-water emulsion and its uses in particular its cosmetic uses

The present invention relates to an oil-in-water emulsion composition, including: an oily phase dispersed in an aqueous phase; wherein the oily phase includes at least one crosslinked solid organopolysiloxane elastomer having at least one oxyalkylene group; and wherein the aqueous phase includes at least one polymer which is soluble or swellable in water. The present invention also relates to a cosmetic composition containing the above-noted composition, and methods of using. The present invention makes it possible to prepare oil-in-water emulsions which are stable even though they may not contain a conventionally used surfactant, this stability persisting even when the level of oily phase is high. Furthermore, the present invention provides compositions that are advantageously fresh and comfortable during application to the skin, which effects are otherwise not obtained with conventional compositions.

- Gel compositions

There is provided a clear antiperspirant/deodorant gel composition. The composition is a water-in-oil emulsion having a viscosity about 7,000 cps to about 25,000 cps and a clarity from about 30 NTU or less. The composition further has an antiperspirant active, water, silicone gelling agent, and one or more silicone oils.

- Method of preparing particularly skin-compatible cosmetic or dermatological cleansing preparations

The use of one or more cosurfactants (surfactant B) in a mixture with one or more surfactants different from surfactant B (surfactant A) for reducing the binding of surfactant A to the surface of the skin.

- Polyanhydrides with biologically active degradation products

Polyanhydrides which degrade into biologically active salicylates and alpha-hydroxy acids and methods of using these polyanhydrides to deliver the salicylates and alpha-hydroxy acids to a host are provided.

- Acidic compositions or dermatological composition containing a crosslinked poly (2-acrylamido-2-methylpropanesulfonic acid) neutralized to at least 90%

The invention relates to a cosmetic or dermatological composition containing an acidic aqueous medium and at least one crosslinked poly(2-acrylamido-2-methylpropanesulfonic acid) polymer neutralized to at least 90%. The composition contains, distributed randomly: (a) from 90 to 99.9% by weight of units of formula (1); and ##STR1## in which X.sup.+ denotes a cation or a mixture of cations, it being possible for at most 10 mol % of the cations X.sup.+ to be protons H.sup.+ ; (b) from 0.01 to 10% by weight of crosslinking units originating from at least one monomer having at least two olefinic double bonds; the proportions by weight being defined with respect to the total weight of the polymer. The invention also relates to the use of this composition in the cosmetic treatment of keratinous substances, in particular of the skin, hair and mucous membranes, and in particular to a non-therapeutic process for depigmentation of the skin.

- Stabilized compositions containing oxygen-labile active agents

The present invention relates to a composition (e.g., a cosmetic composition) comprising, (a) an oxygen labile active agent, (b) erythorbic acid or a cosmetically acceptable salt or ester thereof, (c) optionally, a tocopherol derivative, (d) optionally, a pantothenic acid derivative, and (e) optionally, an extract of green tea, provided that said composition comprises a compound selected from both (c) and (d), both (c) and (e), or both (d) and (e).

- Jasmonate pharmaceutical composition for treatment of cancer

A pharmaceutical composition useful for the treatment of cancer in mamnmals, comprising as the active ingredient a therapeutically effective amount of a jasmonate of the formula: ##STR1## wherein: n is 0,1, or 2; R.sub.1 is OH, alkoxy, O-glucosyl, or imino; R.sub.2 is OH, O, alkoxy or O-glucosyl; R.sub.3, R.sub.4 and R.sub.5 are H, OH, alkoxy or O-glucosyl; and/or wherein R.sup.1 and R.sub.2, or R.sup.1 and R.sub.4 together form a lactone; and further wherein the bonds between C.sub.3 :C.sub.7, C.sub.4 :C.sub.5, and C.sub.9 :C.sub.10 may be double or single bonds; or a derivative of said formula; the derivative having at least one of the following: a lower acyl side chain at C.sub.3 (free acid, ester or conjugate); a keto or hydroxy (free hydroxy or ester) moiety at the C.sub.6 carbon; or an n-pentenyl or n-pentyl side chain at C.sub.7. These jasmonates are useful in treating a wide variety of malignancies.

- Cosmetic treatment method for fighting against skin ageing effects

The present invention relates to a method of cosmetic treatment for combating the effects of skin ageing and to novel cosmetic compositions which are particularly suitable for carrying it out. According to the invention, at least one agent for promoting the adhesion of the keratinocytes of the epidermal baseal layer to the dermo-epidermal junction, especially to the collagen IV of said junction, such as, in particular, a divalent metal salt or complex, preferably magnesium aspartate or magnesium chloride, is used, optionally in association with a stimulant of collagen IV synthesis and/or a stimulant of collagen VII synthesis. The application is for the preparation of cosmetic compositions with anti-wrinkle activity.

- Iridaceae extract and compositions containing it

The subject of the present invention, in its most general aspect, is an extract of cells of at least one plant of the Iridaceae family, the said plant being obtained by in vitro culture. The subject of the invention is also compositions containing an extract of cells of at least one plant of the Iridaceae family, the use of the said extracts as antagonist of CGRP and/or of substance P and a process of cosmetic treatment involving one of the said compositions.

- Active topical skin protectants

A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWAs). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.

- Active topical skin protectants containing S-330

A topical skin protectant formulation containing a barrier cream and a reactive moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barrier property and a reactive moiety that serves to neutralize chemical warfare agents into less toxic agents.

- Anhydrous cosmetic compositions

An anhydrous skin treatment composition is provided which includes a crosslinked siloxane elastomer gel of specific yield point, a skin conditioning agent and a volatile siloxane. Inclusions of the select elastomers provide improved uniform distribution of the pigments.

- Alkoxylated fatty alcohol dicarboxylic acid esters

Fatty alkoxylated esters consisting of diesters of aliphatic or aromatic dicarboxylic acids, formed by reacting the acid with a stoichiometric excess of one or more polyalkoxylated fatty alcohols. Non-aqueous compositions for topical application are also disclosed including one or more active ingredients, and an emollient agent of the fatty alkoxylated esters of the present invention.

- Electrokinetic delivery of medicaments

An electrokinetic delivery or diagnostic device for personal use and self-administration of a medicament to a treatment site is provided. The device includes a housing containing a power supply, a first active electrode and a ground tactile electrode. An applicator includes a pad for containing medicament for overlying the first electrode of the device. The medicament may be applied by the user to the pad, contained within the pad or contained in rupturable capsules within the pad, together with a hydrogel if necessary for imparting electrical conductivity whereby, upon application of the applicator to the treatment site, the medicament is electrokinetically transported into the treatment site. In another form, the applicator is self-contained, having a power supply, a first electrode overlying a pad and a ground electrode from the opposite side from the pad whereby the individual presses the pad against the treatment site to complete the electrical circuit and electrokinetically drive the medicament into the treatment site.

- Elegant hydrogenated castor oil ointments

A topical ointment pharmaceutical composition that uses a lipophilic base, a pharmaceutical active and, dispersed in the base, from about 1% to about 50% by weight of the total composition of hydrogenated non-melted castor oil in powder form. The result of using hydrogenated non-melted castor oil in powder form is a surprising pharmaceutical elegance perceived to be smoother in texture and more spreadable than an ointment made by melting the hydrogenated castor oil.

- Use of alkylmonoglucosides as molecular vectors

The invention concerns the use as molecular vector in pharnaceutical, cosmetic and food products of alkylmonoglucosides of general formula (I) in which R.sub.1 is a linear or branched C.sub.2 -C.sub.18 alkyl radical.

- Composition having bactericidal action, cosmetics containing said composition and ultraviolet ray screening agent

A composition having a bactericidal action is provided which has no toxicity to the human body, and particularly a composition having a bactericidal action is provided which exhibit an excellent therapeutic effect for skin diseases such as atopic dermatitis, acne or the like. A composition, in which an extract from a silk gland and/or a liquid silk is an active ingredient, has a bactericidal action to make renewal of a skin cell, exhibiting an excellent therapeutic effect for skin diseases.

- Antimicrobial wipes which provide improved residual benefit versus gram positive bacteria

The present invention relates to an antimicrobial wipe comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active; from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant; from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent; and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0; wherein the antimicrobial cleansing composition has a Gram Positive Residual Effectiveness Index of greater than about 0.5; and wherein the antimicrobial cleansing composition has a Mildness Index of less than about 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram positive bacteria using these products.

- Encapsulation of active ingredients

A process for preparing free-flowing and, during handling, dust-free microparticles. The particles are at least 90% by weight, have a diameter of 100-400 .mu.m, and contain one or more active ingredients in a glassy matrix. Generally, the process of the invention comprises the steps of (1) preparing an aqueous solution of the matrix materials, (2) mixing the flavor into the aqueous solution with stirring to form an emulsion or suspension, (3) spraying the emulsion in a spray drying tower under a supply of hot air to quickly create a semi-solid skin allowing outtake of moisture (water), and (4) subsequently subjecting the resulting particles to continued drying at lower temperatures in a fluid bed.

- Natural source composition for the control of post-harvest pathologies and methods of application

The composition contains a fundamental active ingredient consisting of the association of thymol, eugenol and cinnamaldehyde, a secondary active ingredient consisting of the association of cuminaldehyde, geraniol, vanillin, borneol, menthol, anethole, terpineol, limonene and different glycosides contained in the essences of mustard and jasmine, a surface-active selected among the different families accepted as emulsifying food additives and an oligosaccharide selected among the mono-oligosaccharides, fructo-oligosaccharides, phyco-oligosaccharides proceeding from algae extracts or vegetable tissue. The composition that has just been described is applied to fruit and vegetables in a diluted bath or in solid form incorporated into the waxes that are usually used in post-harvest treatments.

- Non-or minimally invasive monitoring methods using particle delivery methods

Methods for sampling an analyte present in a biological system are provided. The methods entail use of particle delivery methods to obtain a sample of an analyte of interest from the system.

- Pyridine-thiols for treatment of a follicular dermatosis

This invention provides compositions and methods for treatment of skin and mucous membranes suffering from a follicular dermatosis. The compositions include one or more pyridine-thiols and tautomers with attached metallic moieties. Administration of the compounds to aging skin and mucous membranes in topical formulations, either as the only active ingredient or in combination with other known active ingredients to treat a follicular dermatosis. Additional compositions for treating follicular dermatosis contain one or more sulfides and oxides of these same metallic ions, either alone or in combination with other molecules. Topical formulations containing both a pyridine-thiol and tautomers with attached metallic moiety and a metallic sulfide and/or metallic oxide effectively treat skin and mucous membranes suffering from a follicular dermatosis.

- Anhydrous antiperspirant and deodorant compositions containing solid, encapsulated, d-pantothenate salts

Disclosed are anhydrous antiperspirant and deodorant compositions comprising from about 0.1% to about 30% by weight of an underarm active (antiperspirant and/or deodorant active); from about 0.01% to about 10% by weight of a solid, encapsulated, water-soluble, d-pantothenate salt such as calcium pantothenate; from about 0.1% to about 40% by weight of a suspending agent; and from about 10% to about 99% by weight of an anhydrous carrier liquid. Also disclosed are methods of controlling perspiration wetness and/or odor through the topical application to the underarm, especially shaven underarms, of an underarm active and a solid pantothenate salt. The anhydrous compositions are mild to the skin and can help sooth or heal skin irritated or damaged underarm skin, especially when such irritation and damage is the result of occasional or routine shaving of the underarmn.

- Topical composition comprising a cyclic imidocarbonate-based cosmetic bonding agent

The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a cyclic imidocarbonate bonding agent having the structure ##STR1## wherein X represents a cosmetic benefit agent that may or may not be attached to a chemical linker and R represents NH or O; and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various products that include the claimed compositions.

- Isozyme of autoclavable superoxide dismutase (SOD), a process for the identification and extraction of the SOD in cosmetic, food and pharmaceutical compositions

The invention relates to a novel purified isozyme of an autoclavable superoxide dismutase extracted from the plant Potentilla atrosanguinea Lodd. Var. orgyrophylla, said isozyme having the following characteristics, O.sub.2.sup.- scavenging activity remains same before and after autoclaving; scavenges O.sub.2.sup.- from sub-zero temperature of -20.degree. C. to high temperature of +80.degree. C.; O.sub.2.sup.- scavenging activity at 25.degree. C. for 30 days without adding any stabilizing agent such as polyols or sugars; O.sub.2.sup.- scavenging activity in the presence of saline (0.9% sodium chloride) to 61.8% of the control (without 0.9% sodium chloride), stable at 4.degree. C. for at least 8 months; contamination free and infection free from any living micro- and/or macro-organism after autoclaving; possesses temperature optima at 0.degree. C.; possesses a molecular weight of 33 kD under non-denaturating conditions; possesses a molecular weight of 36 kD under denaturating conditions; has clear peaks in UV range at 268 and 275 nm; has an enzyme turnover number of 19.53.times.10.sup.4 % per nmol per min at 0.degree. C.; and requires Cu/Zn as a co-factor, method for the preparation of the purified isozyme of autoclavable superoxide dismutase and formulations containing the said autoclavable superoxide dismutase.

- Swab deliverable actives

A swab product is provided which includes a swab defined by an elongate stem and a fibrous absorbent covering such as cotton on at least one end of the stem. The fibrous absorbent covering is held together by a film-forming polymer. A treatment agent is provided which includes an active agent in a carrier. Particularly preferred is a highly viscous hydrophobic treatment composition such as petrolatum serving as a carrier for actives such as bacitracin ointment.

- Skin care compositions

Disclosed are skin care compositions that are emulsion formulations comprising an aqueous phase, an oil phase, at least one emulsifier, and an epichlorohydrin cross-linked glyceryl starch.

- Use of 17-.alpha.-estradiol for the treatment of aged or sundamaged skin and/or skin atrophy

The present invention relates to a method for treatment of mammalian skin conditions where stimulated connective tissue synthesis is beneficial, comprising treating skin in need of such treatment with a safe and effective amount of 17-.alpha.-estradiol.

- Oil-in-water emulsions containing high wax content and a softpaste oily phase

A composition in the form of an oil-in-water (o/w) emulsion containing an oily phase dispersed in an aqueous phase, which contains a mixture of nonionic emulsifiers, the mixture being liquid at ambient temperature and having an HLB ranging from about 6 to 13, and in that the oily phase comprises at least about 5% by weight of one or more waxes based on the total weight of the composition, at least one of the waxes having a starting melting temperature of greater than or equal to about 50.degree. C.

- Antimicrobial wipes which provide improved immediate germ reduction

The present invention relates to an antimicrobial wipe effective against Gram positive bacteria, Gram negative bacteria, fungi, yeasts, molds, and viruses comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active; from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant; from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent; and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0; wherein the antimicrobial cleansing composition an One-wash Immediate Germ Reduction Index of greater than about 1.3; and wherein the rinse-off antimicrobial cleansing composition has a Mildness Index of greater than 0.3. The present invention also relates to methods for removing germs from the skin using the antimicrobial wipes described herein.

- Topical composition comprising a functional aromatic derivative cosmetic bonding agent

The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a functional aromatic derivative bonding agent having a structure selected from the group consisting of ##STR1## wherein X is one or more cosmetic benefit agents that may or may not be attached to a chemical linker; Y, Z, and W are selected from the group consisting of H, NO.sub.2, CN, CF.sub.3, SO.sub.2 R, COR, and X; V is selected from the group consisting of F, I, Br, Cl, NO.sub.2, SOPh, N.sub.3, Oar, OSO.sub.2 R, OR, SR, and NH.sub.2 ; V" and Y" are selected from the group consisting of C, N, and combinations thereof; Z" and W" are selected from the group consisting of F, I, Br, Cl, H, SR, X, or combinations thereof; wherein R is an alkyl or phenyl; and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various products that include the claimed compositions.

- Semisolid therapeutic delivery system and combination semisolid, multiparticulate, therapeutic delivery system

A semisolid therapeutic delivery system and combination semisolid, multiparticulate therapeutic delivery system for therapeutic applications is provided which includes a biocompatible semisolid delivery system and a biocompatible combination semisolid, multiparticulate delivery system for injection, deposition, or implantation within the body to facilitate local or systemic therapeutic effects through the actions of incorporated medicaments or actions inherit to the system.

- Skin cleansing agent

The present invention relates to an agent for cleansing the skin, containing a liquid natural and/or synthetic water-based latex emulsion excluding styrene-butadiene latices, exclusively at least one organic solvent which has a lower volatility than ethanol and a boiling point >78.32.degree. C., and water.

- Controlled delivery system for hair care products

The present invention is a controlled delivery system that can be incorporated in hair care products such as shampoos, conditioners, hair styling products, and other hair care products to effectively deliver a broad range of active agents and sensory markers, such as fragrances or cooling agents onto the hair. The system also prolongs the release rate of the active agents or sensory markers over an extended period of time, or provides heat triggered release of the active agents and yields a high impact fragrance "burst" upon blow drying the hair or other types of heat treatment. The controlled delivery system of the present invention is a nano-particle, having an average particle diameter of from about 0.01 microns to about 10 microns. The nano-particle comprises hydrophobic polymers and co-polymers, cationic charge boosters in conjunction with cationic surface-active conditioning agents that assist in adhering the particles onto hair. The invention further relates to a controlled delivery system where the release rate of the active ingredients is synchronized with that of a sensory marker to convey to the consumer the product performance.

- Composition and process for making up keratin substances

A cosmetic make-up composition comprising, in a cosmetically acceptable medium, a dyestuff comprising glass particles coated with at least one metallic coat. The invention also relates to a cosmetic process for making up keratin substances. The make-up obtained can have a sparkling and wear-resistant metallic appearance.

- Topical composition comprising a diazonium salt-based cosmetic bonding agent

The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a diazonium salt bonding agent having the structure ##STR1## wherein X represents a cosmetic benefit agent that may or may not be attached to a chemical linker; and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various products that include the claimed compositions.

- Topical composition comprising a 1,2-heteroatom constituted diene cosmetic bonding agent

The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a 1,2-heteroatom constituted diene bonding agent having the structure: ##STR1## wherein X represents a cosmetic benefit agent that may or may not be attached to a chemical linker, Y represents N, CH, or CW wherein W is an alkyl and R represents O, S, or Se; and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various products that include the claimed compositions.

- Use of at least one lipid extract obtained from the fruit seed of the mirabelle tree

The aim of the invention is to use at least one lipid extract obtained from the fruit seeds of the mirabelle tree as an agent for preparing a cosmetic product for locally active (topical) use for skin and hair, lips, mucous membranes and/or appendages of the skin.

- Controlled release compositions and method

A controlled release composition comprising an adsorbent polymer, an active agent, and a release retardant is disclosed. The composition has an improved ability to release the active agent over an extended time period.

- Skin care compositions containing combination of skin care actives

The present invention relates to skin care compositions containing combinations of skin care actives and to methods of using such compositions to regulate the condition of skin. The compositions contain a safe and effective amount of amount of a peptide active selected from the group consisting of pentapeptides, derivatives of pentapeptides, and mixtures thereof; a safe and effective amount of at least one additional skin care active; and a dermatologically acceptable carrier.

- Topical formulation of alkyl-, phenyl-pyridone

A pharmaceutically acceptable topical formulation for the treatment and/or prevention of skin ailments, more particularly of fibriotic nature such as fibriotic lesional tissues, contiguous warts, contact dermatitis, and keloids, and to assist the healing of burns after surgery, comprising as active ingredient a substituted pyridone of the formula: n-(R.sup.1)-R.sup.2 -2-(1H)pyridone or a pharmaceutically acceptable salt or ester thereof, where R.sup.1 is selected from methyl, ethyl, propyl, carboxyl and a carboxymethyl or carboxyethyl ester group, R.sup.2 is selected from phenyl, methylphenyl, ethylphenyl, propylphenyl, and a carboxyphenyl or carboxyethylphenyl ester group, and n is 3, 4 or 5, together with an excipient, characterized in that the excipient comprises, one or more plasticisers, one or more antioxidants, one or more gel-forming agents and sufficient pH adjusting agent to bring the pH of the formulation to a value from 4 to 8. The preferred active ingredient is 5-methyl-1-phenyl-2-(1H)pyridone (Pirfenidone).

- Glycosaminoglycan and drug compositions containing the same

There is provided a glycosaminoglycan having a backbone structure comprising a repetitive disaccharide bearing a uronic acid residue and a glucosamine residue, and having sulfate groups, wherein substantially no sulfate group bound to the hydroxyl group at the 6-position of the glucosamine residue in the backbone structure is detected as determined by a chemical disaccharide analysis method in which the glycosaminoglycan is decomposed with nitrous acid, reacted with para-nitrophenylhydrazine and analyzed by high performance liquid chromatography, and the molar % of a uronic acid residue having a sulfate group at the 2-position is not less than 45% relative to total uronic acid residues, which is calculated from a disaccharide composition obtained by an enzymatic disaccharide analysis method in which the glycosaminoglycan is digested with glycosaminoglycan-degrading enzymes and analyzed by high performance liquid chromatography. The glycosaminoglycan can be used as an active ingredient of pharmaceuticals.

- Swab deliverable actives

A swab product is provided which includes a swab defined by an elongate stem and a fibrous absorbent covering such as cotton on at least one end of the stem. The fibrous absorbent covering is held together by a film-forming polymer. A treatment composition is dispersed onto the fibrous absorbent covering. Particularly preferred is a highly viscous hydrophobic treatment composition consisting of at least about 80% of petrolatum, which may serve to deliver actives such as bacitracin ointment or by itself serve as an occlusive therapeutic covering of skin to prevent infection.

- Use of mixtures of micropigments for preventing tanning and for lightening skin and hair

The invention describes the use of micronized organic UV filters for preventing tanning and for lightening human skin and hair, and their use in cosmetic and pharmaceutical formulations. The micronized UV filters used according to the invention cover a broad UV spectrum and therefore have excellent sunscreen properties.

- Uses of D-xylose, the esters thereof and oligosaccharides containing xylose for improving the functionality of epidermal cells

A method for stimulating the synthesis and/or secretion of proteoglycans and/or glycosaminoglycans by keratinocytes of a human in need thereof, by applying to an external body area of the human a composition containing an effective amount of D-xylose, an ester thereof or an oligosaccharide containing D-xylose, in a combination with a cosmetically or pharmaceutically acceptable excipient.

- Topical composition comprising a functionalized acid anhydride-based cosmetic bonding agent

The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a functionalized acid anhydride-based bonding agent having the structure ##STR1## wherein X represents a cosmetic benefit agent that may or may not be attached to a chemical linker; and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various products that include the claimed compositions.

- Scytonemin and methods of using thereof

Disclosed are compounds having a scytoneman skeleton, such as scytonemin, and methods of using thereof. Methods of using a compound having a scytoneman skeleton to inhibit, modulate, attenuate, or prevent cell-cycle progression, cell proliferation, kinase activity, or induce apoptosis are disclosed. Also disclosed are methods of treating, preventing, or inhibiting diseases and disorders associated with cell cycle progression, cell proliferation, kinase activity, tissue hyperplasia or angiogenesis, such as cancer or an inflammatory disease.

- Membrane delivery system

The present invention relates to a delivery system for topical application to the skin comprising a freeze-dried, partially cross-linked polymeric gel membrane which can be reversibly returned to a dissolvable gel form upon the application of a wetting agent. The membrane can be used to deliver biologically active agents to the skin.

- Process for limiting the penetration into the skin and/or the keratinous fibres of an active cosmetic and/or pharmaceutical agent

A process, composition, and kit for limiting the penetration into the skin and/or the keratinous fibers of at least one cosmetically and/or pharmaceutically active agent present in a base cosmetic and/or pharmaceutical composition for topical application and in particular for reducing the rate of penetration into the skin and/or the keratinous fibers of the active agent(s). The process includes the joint use, with the base composition, of an effective amount of a dispersion of vesicles in a medium, the vesicles comprising at least one ceramide of formula (I): ##STR1## wherein R.sub.1 is chosen from saturated and unsaturated, linear and branched C.sub.1 -C.sub.32 alkyl groups optionally substituted by at least one hydroxyl group, wherein said at least one hydroxyl group is optionally esterified by a group chosen from C.sub.1 -C.sub.35 acyls; and R.sub.2 is chosen from saturated and unsaturated, linear and branched C.sub.1 -C.sub.50 alkyl groups optionally substituted by at least one hydroxyl groups, and wherein said at least one hydroxyl group is optionally esterified by a group chosen from C.sub.1 -C.sub.30 acyls.

- Silk protein treatment composition and treated substrate for transfer to skin

The present invention relates to a topical delivery system effective in depositing a thin, tenacious and substantially continuous coating of a silk protein on skin by an aqueous emulsion mediated dissolution of protein from a substrate with subsequent transfer and deposition onto the skin. Coatings of silk protein on skin resist removal, thereby providing a protective barrier against chemically- and biochemically-induced skin damage. The treatment composition also provides a vehicle for administering an effective dose of an active agent to the skin surface.

- Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules

Polymeric micelles for encapsulation of hydrophobic molecules are provided. Methods and formulations for delivering hydrophobic molecules to a host via these micelles are also provided. Methods of stabilizing liposomes or lipid based formulations by addition of polymeric micelles are also provided.

- Multifunctional particulate additive for personal care and cosmetic compositions, and the process of making the same

Cosmetic and personal care compositions can be manufactured using the multifunctional-additive compositions of the present invention. Such an additive preferably contains one or more particulate-based thickeners, such as a smectite clay, colloidal silica, laponite, and/or alumina, and most preferably one. or more smectite clays. According to one important embodiment of the present invention, the thickener particles are co-dispersed with particles of one or more particulate UVR-filters such as titanium dioxide, zinc oxide, or SUNSPHERE (available from International Specialty Chemicals, ISP), and most preferably with the natural particulate sunscreens such as the metal oxides. Another important component of the multifunctional-additive compositions is a dispersant or surface-modifier for the foregoing particulate materials, selected from the family of polyphenolic, natural polymers such as lignosulfonates, lignins, humates, tannates, and derivatives thereof. In addition, these compositions optionally include one or more of the following components: electrolytes, defoamers, humectants, emollients for cosmetics, preservatives, whiteners, and the like.

- Delivery of a sacrificial substrate to inhibit protease permeation into skin

The present invention relates to a topical delivery system effective in depositing a thin, tenacious and substantially continuous coating of a sacrificial substrate on skin by an aqueous emulsion mediated dissolution of protein from a sheet material with subsequent transfer and deposition onto the skin. Coatings of sacrificial substrate on skin resist removal, thereby providing a protective barrier against chemically- and biochemically-induced skin damage. The treatment composition also provides a vehicle for administering an effective dose of an active agent to the skin surface.

- Compositions which contain at least one cationic polymer and at least one active molecule contained in at least one micro or nonopartculate vector, and their use for treating living or inert surfaces

The present invention relates to compositions which contain at least one cationic polymer and at least one active molecule contained in at least one micro or nanoparticulate vector, and their use for treating living or inert surfaces.

- Use of colostrinin, constituent peptides thereof, and analogs thereof, as oxidative stress regulators

The present invention provides methods that utilize compositions containing colostrinin, an constituent peptide thereof, an active analog thereof, and combinations thereof, as an oxidative stress regulator.

- Subcutaneous muscle treatment using electronic stimulation and topical compositions

Aging and sagging subcutaneous muscles are treated by first applying a composition containing at least one acetylcholine precursor and/or at least one compound exhibiting catecholamine activity to the overlying skin area, and then electronically stimulating the overlying skin area using electrical pulses in amounts sufficient to cause the subcutaneous muscles to contract. Preferred compositions contain from about 1% to about 10%, more narrowly from about 0.25% to about 5% by weight of an alkanolamine such as dimethylaminoethanol, the calcium salt of 2-aminoethanol phosphate or mixtures thereof and about from about 1% to about 10%, more narrowly from about 1% to 5% by weight of a compound exhibiting catecholamine activity such as tyrosine. Preferred electronic muscle stimulating devices deliver electrical pulses via electrodes in the fingertips of a compact device that fits on the hand.

- Antiperspirant or deodorant compositions

Deodorant and antiperspirant compositions comprising an aluminium or aluminium-zirconium active can suffer from perceived irritancy when applied topically, which is generally manifested as an itch sensation. This irritancy can be ameliorated or overcome by incorporating within the composition a cannabanoid receptor (CBR) activating agent, and especially an amount selected in the range of from 0.25 to 10 wt %.

- Make-up composition containing a blend of waxes

A composition which can be molded in the form of a stick or hot-poured, comprising at least one wax having a melting point of greater than 95.degree. C. and a penetration of from 1 to 7.5 mm, and at least one organically modified beeswax having a penetration of greater than 7.5 mm, wherein the waxes are present in a combined amount sufficient to provide stability and a creamy texture to a molded stick or to a product resulting from hot-pouring, and a process for caring for and/or making-up the eyes, lips, or skin using this composition.

- Water-in-oil emulsion containing fibers and the use thereof as a cosmetic composition

A composition in the form of a water-in-oil emulsion containing fibers, at least one silicone surfactant and-at least one wax. The composition obtained has very good stability and can in particular constitute a cosmetic composition. The invention also relates to the use of the said composition, in particular for caring for, treating, making up or cleansing the skin the lips, the eyelashes and/or the hair.

- Tertiary amide-terminated polyamides in structured personal care compositions

A structured, solid composition that contains at least one colorant, a liquid oil phase, and a gellant, wherein the gellant is a tertiary amide-terminated polyamide resin (ATPA) of the formula (1): ##STR1## wherein, n designates a number of repeating units such that terminal amide groups constitute from 10% to 50% of the total amide groups; R.sup.1 at each occurrence is independently selected from a C.sub.1-22 hydrocarbon group; R.sup.2 at each occurrence is independently selected from a C.sub.2-42 hydrocarbon group; R.sup.3 at each occurrence is independently selected from an organic group containing at least two carbon atoms in addition to hydrogen atoms, and optionally containing one or more oxygen and nitrogen atoms; and R.sup.3a at each occurrence is independently selected from hydrogen, C.sub.1-10 alkyl and a direct bond to R.sup.3 or another R.sup.3a such that the N atom to which R.sup.3 and R.sup.3a are both bonded is part of a heterocyclic structure defined in part by R.sup.3a --N--R.sup.3, the composition being in the form of a solid; the liquid oil phase and the ATPA resin forming a physiologically acceptable medium. The composition may be formulated into a cosmetic or other personal care product, for instance, a black mascara, eye liner, foundation, lipstick, blush, deodorant or make-up remover, body make-up, eye shadow or rouge, or concealer.

- Antimicrobial containing solventless hot melt adhesive composition

An adhesive composition having dispersed therein a broad spectrum antimicrobial agent for use in medical applications, such as an adhesive for surgical drapes, wound dressings and tapes. The adhesive is composed of acrylic polymers, tackifiers and a preferred antimicrobial agent, diiodomethyl-p-tolylsulfone. The adhesive composition is essentially solventless and capable of application in a hot melt process while maintaining stability at elevated temperatures in the range of 275.degree. F. to 350.degree. F., which not only allows hot melt application, but allows for ethylene oxide sterilization under heat stress.

- Matrix protein compositions for wound healing

Active enamel substances may be used for the preparation of a pharmaceutical or cosmetic composition for healing of a wound, improving healing of a wound, soft tissue regeneration or repair, or for preventing or treating infection or inflammation.

- Pharmaceutical composition and method for treating hypogonadism

A pharmaceutical composition useful for treating hypogonadism is disclosed. The composition comprises an androgenic or anabolic steroid, a C1-C4 alcohol, a penetration enhancer such as isopropyl myristate, and water. Also disclosed is a method for treating hypogonadism utilizing the composition.

- Topical product with visual indicator

A product for application to the skin includes a container and a composition within the container including a cosmetic or therapeutic active ingredient. Sometime after first use, the application surface of the composition changes from a first visual appearance to a second visual appearance due to a change in the composition.

- Cosmetic or dermatological composition in the form of a dispersion of an oily phase and an aqueous phase, stabilized with cubic gel particles

W/O or O/W stable dispersions are formed by mixing an oily phase and an aqueous phase when the dispersion is stabilized with cubic gel particles formed by the combination of two amphiphilic compounds, one of the amphiphilic compounds being capable of forming a lamellar phase in the presence of water, and the other being capable of forming an inverse hexagonal phase in the presence of water.

- Process for the extraction of an active principle from teguments of apple, active principle obtained, and composition for counteracting the consequences of oxidative stress of the skin

The present invention is a process for the extraction of an active principle for action against the consequences of oxidative stress, permitting countering cutaneous aging, characterized in that it comprises the following steps: reduction to fine powder of dried apple tegument, solubilization of this powder with at least 8% by volume of powder in an aqueous solution, conjoint enzymatic hydrolysis of the sugars and proteins, heating permitting total inactivation of the enzymes, and sterilizing filtration to retain the microorganisms, yeasts and molds as well as the total mesophilic flora. The invention also covers the associated compositions and a process for countering accelerated aging of the skin.

- Complex skin, slush molding thermoplastic elastomer composition for use in the skin, and an article including the skin

A multilayer skin comprising an outer layer prepared by slush molding powder of a thermoplastic elastomer composition having a polypropylene resin, a hydrogenated styrene-butadiene random copolymer rubber, a process oil, an elastomer with high oil absorption capability, and a release agent. An inner layer is bonded to the outer layer, is prepared by slush molding, and is a blend of an elastomer with high oil absorption capability, an olefinic polymer with active hydrogen, and a catalyst which promotes isocyanate reaction. There is also a multilayer skin with a different composition as well as an article made with a multilayer skin having the compositions. There is further a thermoplastic elastomer composition for a layer of a multilayer skin.

- Inhibitors of cellular niacinamide mononucleotide formation and their use in cancer therapy

New biologically active compounds are described which inhibit the cellular formation of niacinamide mononucleotide, and essential intermediate of the NAD(P) biosynthesis in the cell. These compounds can represent the active ingredient of a pharmaceutical composition for the treatment of cancers, leukaemias or for immunosuppression. Furthermore, screening methods are described as a tool for detecting the above active compounds, and for examination of a given cell type for its dependency on niacinamide as a precursor for NAD synthesis.

- Elastin peptide analogs and methods of using same

The present invention is directed to a composition which is used to enhance the elasticity and/or appearance of tissue. Specifically, the present invention is directed to a composition formulated from peptides having low molecular weights and which substantially correspond to sequences found in elastin More preferably, the present invention corresponds to the general formula R.sub.1 -Leucine-Glycine-Alanine-Glycine-Glycine-Alanine-Glycine-R.sub.2.

- Morpholine derivatives, method for the production thereof and pharmaceutical preparations containing said derivatives

N-(phenylacetyl)morpholine derivatives useful as NK1 receptor antagonists, a process for the preparation thereof, and pharmaceutical compositions containing them as active principle.

- Use of a RAR-.gamma.-specific agonist ligand for increasing the rate of apoptosis

Methods of cosmetically or therapeutically treating diseases or disorders in cell populations whose pathology is linked to an inadequate rate of apoptosis by administering a therapeutically effective amount of 6-3-(1-adamantyl)-4-hydroxyphenyl)-2-naphthanoic acid.

- Solubilization of 1,3,5-triazine derivatives with N-acyl amino acid esters

A composition comprising at least one 1,3,5-triazine derivative and at least one N-acyl amino acid ester and its use in or for the manufacture of compositions, especially cosmetic and dermatological compositions for protecting the skin and/or the lips and/or integuments against ultraviolet radiation, in particular solar radiation. In addition, a cosmetic treatment process comprising the application of the cosmetic composition, and the use of the at least one N-acyl amino acid ester, in anti-sun compositions containing a 1,3,5-triazine derivative to improve the sun protection factor of the composition.

- Cosmetic products for the reduction of sweat acidity

A cosmetic method of reducing the acidity of sweat excreted from human eccrine glands, said method comprising the topical application of a V-ATPase inhibitor to the skin in the vicinity of the eccrine glands. Said method may result in a range of benefits, including enhanced appreciation of topically-applied perfume and enhanced efficacy of topically-applied antiperspirant salt. Cosmetic products and compositions comprising a V-ATPase inhibitor and selected other components are also claimed.

- Composition in the form of water-in-oil emulsion and its cosmetic uses

The first embodiment of the present invention provides a composition, which includes: an aqueous phase dispersed in an oily phase; wherein the oily phase includes at least one particle of a crosslinked solid organopolysiloxane elastomer having at least one oxyalkylene group, and wherein the aqueous phase includes at least one crosslinked and at least partially neutralized poly(2-acrylamido-2-methylpropanesulphonic acid) polymer. Other embodiments of the present invention provide methods of using the above-identified composition, compositions containing same, and a method of preparing water-in-oil emulsions.

- System for polymerizing collagen and collagen composites in situ for a tissue compatible wound sealant, delivery vehicle, binding agent and/or chemically modifiable matrix

This invention relates to materials and methods for crosslinking, in situ, proteins, including collagen, with peroxidase, including horseradish peroxidase, to from biocompatible semi-solid gels useful in a number of biological and food product applications.

- Anti viral composition

Disclosed is a pharmaceutical composition., especially for treating herpes and condyloma, comprising an extraction product of broad beans, as an active ingredient.

- Cosmetic or dermatological preparations of the oil-in-water type

Low-viscosity cosmetic or dermatological preparations of the oil-in-water type, which comprise an oil phase, in which hydrophobic and/or amphiphilic solids are incorporated, and a water phase, where the difference in density between the oil phase and the water phase (determinable using a computerized digital density meter of the type DMA 45 from chempro/PA at 25.degree. C.) is not greater than 0.01 g.multidot.cm.sup.-3, and method of stabilizing O/W formulations.

- Pyrimidine 3-oxide compounds for inducing/stimulating hair growth and/or retarding hair loss

Hair growth-/hair loss-affecting cosmetic/therapeutic compositions contain an effective amount of at least one 2-amino-4-alkylaminopyrimidine 3-oxide having the structural formula (I): ##STR1## in which R.sub.1 is an alkyl radical having from 5 to 20 carbon atoms, and Z is either a hydrogen atom or a radical --OR.sub.2, wherein R.sub.2 is an alkyl radical having from 1 to 12 carbon atoms, or an acyl derivative or acid addition salt thereof.

- Use of plant extracts with an anti-radical-type action

The use of plant extracts, especially plant extracts with an anti-radical-type action, and a cosmetic or dermo-pharmaceutical composition containing extracts of this type. The use of at least one plant extract whose botanical genus belongs to the group formed by the following: Clidemia, Inga, Sabicea, Astrocaryum, Siparuna, Eperua, Byrsonima, Priva, Coutoubea and Goupia genera; as an active substance which has especially anti-radical-type activities, for preparing a cosmetic or dermopharmaceutical product for local, external use for the skin, the mucous membranes and/or the epithel or appendage structures.

- Fast cure film forming formulation

A formulation for depositing a film on a substrate comprising 5 to79.9 wt. % of an alkylene trialkoxy terminated polysiloxane; 0.01 to 5 wt. % of a catalyst; 20 to 94.99 to wt % of a volatile diluent, and, optionally, 0.01 to 5 wt. % of an alkoxysilane and 0.1 to 25 wt % of a filler. The formulations are especially valuable for forming films to be used in personal care or healthcare applications.

- Methods for delivering agents using alternating current

A variety of methods for transporting different agents such as pharmaceutical agents, nutrients and genetic materials across a tissue are provided. The methods utilize an AC signal to maintain a substantially constant electrical state in a region of the tissue through which transport occurs, thereby allowing agent to be transported across the tissue in a controlled and predictable manner. Certain methods include an optional AC or DC prepulse signal to initially achieve the target electrical state. An optional DC offset signal can also be included to assist in promoting transfer of the agent. The methods have utility in a variety of different clinical settings and applications.

- Combinations of sunscreens

Combinations of sunscreens comprising at least one specific anti uv-B filter with triazinoaniline structure and at least one specific anti UV-A filter selected from filters with benzoxazol substituted triazinoaniline structure and a long chain alkyl ester of a benzoxazolyl-aminophenyl-cyanoacrylic acid. Cosmetic and dermatological compositions containing them, optionally in combination with vitamins and/or other anti UV-A and anti UV-B filters.

- Composition for topical application comprising at least one iminophenol compound

The invention relates to a composition for topical application to the skin and/or its superficial growths comprising, in a cosmetically and/or dermatologically acceptable medium, at least one compound comprising an iminophenol fragment and to the use of the said compound in a composition as agent for depigmenting and/or lightening the human skin, the body hairs and/or the hair. It also relates to a process for depigmenting and/or lightening the skin, the body hairs and/or the hair which consists in applying the abovementioned composition to the human skin, the body hairs and/or the hair.

- Hydroxydecenoic acid compounds for promoting desquamation/epidermal renewal of the skin and/or combating skin aging

10-Hydroxy-2-decenoic acid and derivatives thereof are well suited for promoting desquamation and/or stimulating epidermal renewal and/or combating intrinsic/extrinsic aging of the skin of a candidate individual in need of such treatment, by administering thereto, for such period of time as required to elicit the desired response, an effective amount of at least one of said 10-hydroxy-2-decenoic acid or derivative thereof.

- Bioabsorbable, biocompatible polymers for tissue engineering

Bioabsorbable biocompatible polymers which provide a good match between their properties and those of certain tissue structures are provided. The bioabsorbable biocompatible polymers can be prepared with tensile strengths, elongation to breaks, and/or tensile modulus (Young's modulus) values of the tissues of the cardiovascular, gastrointestinal, kidney and genitourinary, musculoskeletal, and nervous systems, as well as those of the oral, dental, periodontal, and skin tissues. Methods for processing the bioabsorbable biocompatible polymers into tissue engineering devices are also provided.

- Polybifunctional reagent having a polymeric backbone and latent reactive moieties and bioactive groups

A polybifunctional reagent is provided having a polymeric backbone, one or more pendent latent reactive (preferably photoreactive) moieties, and two or more pendent bioactive groups. The reagent can be activated to form a bulk material or can be brought into contact with the surface of a previously formed biomaterial and activated to form a coating. The pendent bioactive groups function by promoting the attachment of specific molecules or cells to the bulk material or coated surface. Bioactive groups can include proteins, peptides, carbohydrates, nucleic acids and other molecules that are capable of binding noncovalently to specific and complimentary portions of molecules or cells.

- Sunscreen emulsion composition and method of use

There is provided a sunscreen emulsion composition. The composition has an inner discontinuous phase and an outer continuous phase. The inner discontinuous phase and/or outer continuous phase has a sunscreen active therein. The inner discontinuous phase is generally dispersed in the outer continuous phase and is in the form of discrete droplets having a multimodal droplet size distribution. There is also provided a method of protecting skin from overexposure to the sun in which the above composition is applied topically to the skin. There is also provided a method of enhancing the performance of a sunscreen emulsion by forming the inner discontinuous phase as a multiplicity of droplets having a multimodal droplet size distribution. There is also provided a method of preparing an emulsifier-free sunscreen composition.

- Antiperspirant suspensions containing finely divided aluminium and zirconium, having better effectiveness and a process for their manufacture

An antiperspirant suspension which is finely divided, which is contained in a non-aqueous phase, and which has improved efficacy for perspiration reduction when used on human skin, includes at least one basic aluminum-zirconium-halogenohydrate complex as active ingredient in which at least 60% of the zirconium content can be directly titrated after dissolving in 0.1 n HCl with EDTA at a pH of 0.8, wherein the active ingredient optionally contains an amino acid. A process for the synthesis of the antiperspirant suspension includes mixing an aluminum salt which is effective as an antiperspirant with a zirconium salt which is effective as an antiperspirant, optionally in the presence of an amino acid, in a non-aqueous oil phase in the absence of water to provide a mixture; and grinding the mixture.

- Topical gel delivery system

A composition is provided that has a viscosity of less than about 15,000 cP and a pH of about 3.0 to 9.0 for treating a skin disorder in a human subject. The composition is a lotion that consists essentially of (a) a therapeutically-effective amount of at least one compound useful for treating such disorder, (b) a pharmaceutically-acceptable, lightly cross-linked polyacrylic acid polymer compatible with the compound, (c) a pharmaceutically acceptable base to adjust pH, (d) up to about 25% ww of at least one water miscible solvent, (e) optionally a preservative, (f) water, and (g) an oil phase component and suitable surfactant. The composition is useful for treating an inflammatory skin disorder, acne, or rosacea.

- Method of electroporation-enhanced delivery of active agents

Methods are provided for introducing a biologically active agent into cells of a subject by injecting the agent with a needle-free injector and applying a pulsed electric field to the region of tissue to cause electrotransport of the agent into cells of the tissue. Preferably the agent is either ionized to some degree or contained in an ionized medium for electrotransport. The needle-free injector can serve as an electrode by which the pulsed electric field is applied to the region of tissue. The active agents delivered into cells by this method include small molecules, polynucleotides, polypeptides, and the like. Polynucleotides introduced into cells using this method can be used to accomplish gene therapy or to modulate expression of an endogenous gene.

- Inorganic/organic complexes for reducing skin irritation

.beta.-Diketone/hydroxylated or carbonated activated cation inorganic/organic complexes are well suited for reducing skin irritation, notably that elicited by exposure to irritant active agents/species or to the external environment.

- Matrix metalloproteinase inhibitors

A compound of the general formula I ##STR1## wherein Y is O or S; n is 1, 2, 3 or 4; X represents hydroxamic acid, carboxylic acid, phosphonic acid, acetylthiomethyl group or a mercaptomethyl group; R1 is ##STR2## wherein E, when present represents, a bond or optionally substituted methylene or ethylene; s and t are independently 0, 1, 2 or 3; A and A' independently represent a bond, or a saturated or unsaturated, optionally substituted cyclic or heterocyclic hydrocarbon di- or triradical; Z represents a bond, O, S, C(O), C(O)NR7, NR7C(O) or NR7, wherein R7 is hydrogen, hydroxy, branched or straight, saturated or unsaturated, optionally substituted hydrocarbon radical; R5 represents a bond, alkane or alkene diradical, one or more ether diradicals (R--O--R') or amine diradicals (R--N--R'), wherein R and R' independently represent alkane or alkene diradicals with a C-content from 0 to 3; R6 represents hydrogen, hydroxy, halogen, cyano, nitro, branched or straight, saturated or unsaturated, optionally substituted hydrocarbon radical, unsaturated optionally substituted cyclic or heterocyclic hydrocarbon radical, NR8R9, C(O)NR8R9, C(O)R8, CO(O)R8, S(O).sub.2 R9, wherein each R8 and R9 independently represent hydrogen, halogen, a branched or straight, saturated or unsaturated, optionally substituted hydrocarbon radical; R2 represents hydrogen, (C.sub.1-8)alkyl, (C.sub.2-6)alkenyl, (C.sub.3-8)cycloalkyl, aryl(C.sub.0-6)alkyl or heteroaryl(C.sub.0-6)alkyl; provided that if A, A', Z and R5 are all bonds, and s and t are both 0 (zero), then R6 is different from hydrogen; or a salt, hydrate or solvate thereof. The compounds are valuable for human and veterinary therapy.

- Urethane(meth)acrylates containing siloxane groups and able to undergo free-radical polymerization

The present invention relates to free-radically polymerizable, siloxane-containing urethane (meth)acrylates which comprise, in incorporated form, a) at least one compound which contains at least one active hydrogen atom and at least one free-radically polymerizable .alpha.,.beta.-ethylenically unsaturated double bond per molecule, b) at least one diisocyanate, c) at least one compound which contains two active hydrogen atoms per molecules, d) at least one compound which contains at least one active hydrogen atom and at least one siloxane group per molecule, to water-soluble or water-dispersible polymers which comprise these urethane (meth)acrylates in copolymerized form, to the use of these polymers, and to cosmetic compositions which comprise these polymers.

- N-acetyl aldosamines and related N-acetyl compounds, and their topical use

Compositions comprising N-acetyl-aldosamines, N-acetylamino acids, and related N-acetyl compounds are useful to alleviate or improve various cosmetic conditions and dermatological disorders, including changes or damage to skin, nail and hair associated with intrinsic aging and/or extrinsic aging, as well as changes or damage caused by extrinsic factors. N-acetyl-aldosamines, N-acetylamino acids, and related N-acetyl composition may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

- Cyclodextrins preferentially substituted on their primary face by acid or amine functions

Non-hydroxyalkylated cyclodextrins are disclosed wherein at least one primary alcohol function (CH.sub.2 OH) is substituted, the --OH portion being replaced by a substituent with formula --O--CO--R or --NR.sub.1 R.sub.2, where: R, R.sub.1 and R.sub.2 independently represent a linear or cyclic, saturated or unsaturated, hydroxylated or non-hydroxylated alkyl group containing 1 to 30 carbon atoms, preferably 1 to 22 carbon atoms, more preferably a fatty chain containing 2 to 22 carbon atoms. These cyclodextrins are used as vectors for at least one active ingredient, in particular to encourage tissue penetration, in a cosmetic application, or for the production of pharmaceutical compositions, in particular dermopharmaceuticals.

- Cosmetic compositions

The invention relates to cosmetic compositions comprising a combination of non-emulsifying and emulsifying crosslinked siloxane elastomers.

- Therapeutic compositions and methods of use thereof

A therapeutic composition and a method of using the composition are provided. The composition includes an osmotic agent and an active agent. The osmotic agent improves the delivery of the active agent to the targeted tissue site.

- Physiologically active extract obtained from indigo plant polygonum tinctorium

A physiologically active extract comprising an ethyl acetate-soluble ingredient of an indigo plant, which is obtainable by soaking a raw indigo plant in an organic solvent used for extraction. The ethyl acetate-soluble ingredient includes tryptanthrin, 3,5,4'-trihydroxy-6,7-methylenedioxy-flavone, kaempferol, 3,5,7,4'-tetrahydroxy-6-methoxy-flavone, gallic acid, caffeic acid, indirubin, pheophorbide a, and methylpheophorbide a.

- Ozone generating apparatus and corona generating apparatus

One of the electrodes is covered an insulated material outer skin and is formed with a long wire shape, a band shape or a plate shape. Another of the electrodes is formed with a bare wire by suiting the various shapes and is formed along another insulated core wire and is arranged closely contact with a parallel shape, a right angle shape, a spiral shape, a net shape or a zigzag shape. Accordingly it is possible to lower the voltage. The both electrodes are separated electrically and mechanically using an insulated material and in an ozone generation portion the both electrodes are separated completely.

- Solid cosmetic composition and uses thereof

A solid composition for topical application comprising, in an aqueous phase, a gelling system comprising (i) gellan gum, (ii) at least one other hydrocolloid chosen from the group formed by xanthan gum, carboxymethylcellulose, hydroxypropylcellulose, methylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, agar-agar, carrageenans, alginates, carob gum, guar gum, gum arabic, karaya gum, gum tragacanth, ghatti gum, pectins, gelatin, caseinates and hydroxypropylguar, and (iii) at least one amphiphilic polymer comprising at least one fatty chain and at least one hydrophilic unit.

- Biodegradable polymer composition

A flowable composition containing a biocompatible, biodegradable, branched thermoplastic polymer is used to form solid matrices such as implants and controlled-release, drug-compositions in a body. The flowable composition with or without bioactive agent can be administered by syringe and needle to form in situ a solid matrix. Alternatively, the flowable composition can be used to form ex vivo solid biodegradable matrices such as articles, implants and devices. The articles implants and the like can then used as solid fasteners, prosthetic devices, and controlled drug compositions.

- Treatment regime for skin

A method for a skin treatment regime and a respective product is provided which cosmetically improves human skin. The product includes a first composition containing at least one active and functioning to impart a first benefit to the skin. A second composition is provided which includes a second different active and imparts a second benefit to the skin. The first and second compositions are stored in respective separate containers, which nevertheless are joined together for reminding a consumer to use the compositions in tandem and to facilitate in one sale all necessary elements of a suggested regime. Packaging suitable for this purposes can be a series of stackable jars releasably lockable together through a threaded screw arrangement one above the other.

- Topical compositions with a reversible photochromic ingredient

There are provided topical compositions having reversible visible change in color in response to change in light. The compositions comprise color changing capability provided by photochromic material and a vehicle acceptable for topical application to the skin or hair.

- Process for the extraction of an active principle from yeast for the treatment of wrinkles and cosmetic compositions thereof

A process for extracting an active principle from yeast whereby the active principle is used to retard the degradation of the dermo-epidermal junction to improve the surface condition of the skin. The process includes forming a mixture of solubilized ground yeast in a basic medium, hydrolyzing the proteins of the mixture in a basic medium, agitating the mixture for 8 to 52 hours, filtering the mixture to separate the soluble and insoluble phases, washing with water so as to purify the active ingredient, concentrating and filtering to increase an active oligosaccharide fraction, and sterile filtering the active fraction. The active fraction is characterized by a quantity of dry material between 10 and 200 g/l, a quantity of total sugar between 10 and 100 g/l, a weight ratio of sugar/protein, and a pH between 4 and 10.

- Anti-irritant compositions containing a cyclic nucleotide

The present invention relates to cosmetic or pharmaceutical topical compositions containing at least one cyclic nucleotide having its 2' hydroxyl group replaced by a hydrogen atom for inhibiting phosphodiesterase activity. The phosphodiesterase inhibitor is in combination with a magnesium buffer and a cosmetically or pharmaceutically acceptable carrier. The invention also includes methods for treating or preventing inflammation or irritation such as is common in the skin disease, atopic dermatitis, which is known to be related to the uncontrolled activity of phosphodiesterase.

- Estradiol-containing patch for transdermal application of hormones

An active substance-containing patch for controlled release of estradiol or its pharmaceutically acceptable derivatives, alone or in combination with gestagens, to the human or animal skin, consisting of a backing layer, an active substance-containing reservoir connected thereto which is suitable for combined active substance release and which has been produced using pressure-sensitive adhesives, and a detachable protective layer, is characterized in that the pressure-sensitive adhesive contains wool wax or components thereof and zinc oxide.

- Composition with azelaic acid

The invention relates to a pharmaceutical composition having the following constituents: azelaic acid, polyacrylic acid, triacylglyceride, propylene glycol, polysorbate, soya lecithin, water and salts. The composition is a hydrogel which is suited for the treatment of rosacea, presbyderma, melasma or skin irritations.

- Process for increasing the persistence of at least one cosmetic effect and/or care effect of a cosmetic composition, cosmetic composition and use thereof

The present invention relates to a process for increasing the persistence of at least one cosmetic and/or care effect of a cosmetic composition comprising an oily phase. This process comprises the incorporation into this oily phase of at least one linear or cyclic polyorganosiloxane which comprises at least two organosiloxy units and at least two side and/or end groups which are each capable of forming at least one hydrogen bond with one or more partner groups. The process may be applied, for example, to lipsticks, mascaras or eyeliners to increase the persistence of their coloring effect and/or gloss, to foundations, powders, blushers and eyeshadow to increase the persistence of the matt effect, and to care products such as moisturizing products, deodorants or antiperspirants to increase the persistence of their active care agents. The invention also relates to a cosmetic composition, the persistence of at least one cosmetic and/or care effect of which is increased, and which is intended to be used on the skin, the lips and superficial body growths.

- Oxa acids and related compounds for treating skin conditions

The present invention is directed to the use of compounds of Formula (I), as active principals for treating skin conditions and compositions containing these compounds ##STR1## wherein R.sub.4 is (CR.sub.5 R.sub.6 -CR.sub.7 R.sub.8 1-X.sub.1).sub.n -CR.sub.9 R.sub.10 R.sub.11 ; n is an integer from 1 to 18; R.sub.1, R.sub.2, R.sub.3, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11, are independently, herein defined and X, X.sub.1, Y and Z are independently, 0, NH or S.

- Skin lightening compositions

This invention relates to compositions, compounds, and methods for lightening skin, using active compounds having the general structure: ##STR1## wherein each X is halo; m is 1 to 4; each R' and R" is independently selected from hydrogen, halo, C.sub.1 -C.sub.10 alkyl, substituted C.sub.1 -C.sub.10 alkyl, substituted or unsubstituted phenyl, substituted or unsubstituted naphthyl, OR, OCOR, OCRROR, COR, CR(OR)OR, CONRR, COOR, CRROR, CN, SR, and NRR; each R is selected from hydrogen, C.sub.1 -C.sub.10 alkyl, substituted C.sub.1 -C.sub.10 alkyl, substituted or unsubstituted phenyl, and substituted or unsubstituted naphthyl; n is 1 to 5; Z is O; in an amount effective to lighten skin; and a pharmaceutically-acceptable carrier therefor.

- Pharmaceutical dosage form for transdermal administration

The present invention relates to a process for administering an active principle to a patient transdermally, which comprises the formation of a film on the patient's skin, by applying to the skin a liquid solution which consists essentially of: a) a lipophilic active principle, b) from 2.5 to 25% by weight of a silicone-based adhesive polymer composition, c) from 0 to 25% by weight of an absorption promoter, and d) from 25 to 95% by weight of volatile solvents comprising volatile silicones.

- Method of reducing or preventing malodour

A method of reducing or preventing body malodour by topically applying to human skin perfume components capable of inhibiting the producation of odoriferous steroids by microorganisms on the skin. The perfume components are capable of inhibiting bacterial 4-ene reductase and/or 5.alpha.-reductase.

- Nanoemulsion based on glycerol fatty esters, and its uses in the cosmetics, dermatological and/or ophthalmological fields

The present invention provides a nanoemulsion, that includes: an oily phase dispersed in an aqueous phase; and at least one glycerol fatty ester surfactant which is solid at a temperature of less than or equal to 45.degree. C.; wherein the oily phase includes oil globules having a number-average size of less than 100 nm; wherein the oily phase includes at least one oil having a molecular weight of greater than 400; and wherein a weight ratio of the oily phase to the surfactant ranges from 2 to 10. The invention also provides a process for making the nanoemulsion and methods for its use. Ideally, the emulsion is transparent and stable on storage. It can ideally contain large amounts of oil while retaining good transparency and good cosmetic properties. The nanoemulsion is particularly useful in the cosmetics and dermatological fields, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and, in the ophthalmological field, as an eye lotion for treating the eyes.

- Aminobenzophenones as inhibitors of IL 1.beta. and TNF-.alpha.

A compound of the general formula I ##STR1## wherein R.sub.1 represents a substituent selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amino, (C.sub.1 -C.sub.3)alkyl, (C.sub.2 -C.sub.3)olefinic group, (C.sub.1 -C.sub.3)alkoxy, (C.sub.1 -C.sub.3)alkylthio, (C.sub.1 -C.sub.6)alkylamino, (C.sub.1 -C.sub.3)alkoxycarbonyl, cyano, --CONH.sub.2, phenyl, and nitro; R.sub.2 represents one or more, same or different substituents selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, amino, (C.sub.1 -C.sub.3)alkyl, (C.sub.2 -C.sub.3)olefinic group, (C.sub.1 -C.sub.3)alkoxy, (C.sub.1 -C.sub.3)alkylthio, (C.sub.1 -C.sub.6)alkylamino, (C.sub.1 -C.sub.3)alkoxycarbonyl, cyano, --CONH.sub.2, phenyl, and nitro; R.sub.3 represents one or more, same or different substituents selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, cyano, carboxy, carbamoyl, (C.sub.1 -C.sub.10)alkyl, (C.sub.2 -C.sub.10)olefinic group, (C.sub.3 -C.sub.8)monocyclic hydrocarbon group, (C.sub.1 -C.sub.10)alkoxy, (C.sub.1 -C.sub.10)alkylthio, (C.sub.1 -C.sub.10)alkoxycarbonyl, and phenyl; R.sub.4 represents hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.6)olefinic group, or (C.sub.3 -C.sub.6)monocyclic hydrocarbon group; R.sub.5 represents one or more, same or different substituents selected from the group consisting of hydrogen and R.sub.1 ; X represents oxygen, sulphur, or N--OH; and salts thereof with pharmaceutically acceptable acids, hydrates and solvates, may be used in the prophylaxis or treatment of inflammatory diseases.

- Cell seeding of ceramic compositions

The present invention provides a synthetic, poorly-crystalline apatitic (PCA) calcium phosphate material seeded with cells. Preferably, the cells are tissue-forming or tissue-degrading cells. The compositions provided by the present invention are useful for a variety of applications, including in vivo and in vitro tissue growth (preferably bone or cartilage), osseous augmentation, and methods of diagnosing disease states by assaying tissue-forming potential of cells isolated from a host. The invention also provides in vitro cell culture systems and cell encapsulation matrices.

- Skin care composition

There are provided compositions which include a retinoid and preferably retinol; a dermatologically active acid; and a volatile base, such as ammonium hydroxide. Another embodiment of the invention includes compositions comprising a retinoid and preferably retinol; a dermatologically active acid; a volatile base; and a second neutralizing agent. There are also provided compositions which include a retinoid, a neutralized ammonium salt of a dermatologically active acid, and optionally a neutralized salt, other than ammonium salt, of an acid. Further provided are methods for reducing fine lines, wrinkles, skin roughness, and pore size and for increasing the clarity of a skin surface, cellular turnover, skin radiance, skin smoothness, skin permeation or collagen synthesis in a mammal in need thereof. Compositions as described above are administered topically to the skin of the animal.

- Composition containing an unstable active agent in an oxidizing medium and uses thereof, especially cosmetic uses

The invention relates to a composition containing, in a physiologically acceptable medium, an unstable active agent in an oxidizing medium and an oil phase comprising cross-linked elastomer solid organopolysiloxane particles consisting of at least one oxyalkylene group and oxyethylene in particular. The unstable active agent in an oxidizing medium is stabilized in the inventive composition. The invention also relates to the use of cross-linked elastomer solid organopolysiloxane particles having an oxyalkylene group for the stabilization of an unstable active agent in an oxidizing medium. The unstable active agent can be vitamin C, vitamin A and/or carotenoids. The composition can be anhydrous or take the form of an emulsion. It is particularly suitable for use in cosmetics. It is soft and fresh when applied, spreads easily, is not sticky and does not make the skin or lips dry.

- 10-hydroxy-2-decenoic acid compounds for promoting desquamation/epidermal renewal of the skin and/or combating skin aging

10-Hydroxy-2-decenoic acid compounds, particularly the 10-hydroxydec-2-enoates, are well suited for promoting desquamation of human skin and/or stimulating epidermal renewal and thus combating intrinsic and/or extrinsic cutaneous aging.

- Integrated apparatus for controlled heat aided dermal drug delivery

An integrated apparatus for controlled heat aided dermal drug delivery is disclosed. The apparatus has a temperature control component and a drug delivery component. The temperature control component may and dermal drug delivery component are an integrated unit. The apparatus also comprises means to prevent exchange of substance(s) among the heat generating component, the drug delivery component and the outside environment. The apparatus is designed to be easy to use.

- Make-up or care composition containing a crosslinked polyorganosiloxane containing an oxyalkylenated group

The present invention provides a dermatologic or cosmetic composition, including a liquid fatty phase, and, as surfactant and thickener for the liquid fatty phase, particles of a crosslinked elastomeric solid polyorganosiloxane containing at least one oxyalkylenated group. Another embodiment of the invention relates to methods of using particles of a crosslinked elastomeric solid polyorganosiloxane containing at least one oxyethylenated group. The present invention is especially suitable for a care or make-up composition for human skin and lips, and overcomes the various drawbacks in known compositions. In particular, the present invention provides a composition for human skin and lips that results in a film that does not transfer; that has better cosmetic properties, freshness and matte-effect properties; and that is desirably longer-lasting than conventional "transfer-resistant" products, in particular the properties of slipperiness, of not feeling taut and of not drying out the lips, of having good staying power over time, particularly with respect to the color (no color change over time) and of not migrating, in particular into the folds of the skin. The invention applies not only to make-up products for human lips and skin, but also to care and/or treatment products for human lips and skin. The composition of the invention can also be applied to the scalp.

- Skin care compositions

The present invention relates to topical compositions for effecting an immediate improvement in the appearance and feel of skin, in addition to providing chronic improvements in skin appearance. The compositions comprise from 0.5% to 25% of a first particulate material having a refractive index of from 1.3 to 1.7, the particulate material being dispersed in the composition and having a median particle size of from 2 to 30 um, and an active effective for chronically regulating skin condition selected from Vitamin B3 compounds, retinoids, and mixtures thereof. Preferred emobodiments are oil in water emulsions further comprising a second particulate material having a larger particle size than the first.

- Cosmetic product containing enzymes

The invention relates to a cosmetic product that contains enzymes and has an intensive skin action, especially a regenerative effect The inventive cosmetic product contains 0.01 to 5 wt. % of a concentrate of the coconut milk of Cocos nucifera, containing peroxidase, lipase and protease; 0.1 to 10 wt. % of a plant milkwater, the plants being selected from the following group: banana, dandelion, convolvus, poppy, soya and mixtures thereof; and 0.01 to 5 wt. % of a glycerol extract of a mixture consisting of honey, rice hulls, rice hull oil and/or rice germ oil; with the remainder consisting of cosmetic auxiliary agents, active agents and carrier substances.

- Pharmaceutical cyclosporin formulation with improved biopharmaceutical properties, improved physical quality and greater stability, and method for producing said formulation

The invention relates to solid, particulate lipid-based excipients which are loaded with cyclosporine. Said excipients have improved biopharmaceutical properties for cyclosporines in vivo, are of a better quality (in terms of fineness, homogeneity of the particles, inclusion of the medicament) and are more physically stable in the particulate formulation (no aggregation or gel formation). The invention also relates to a therapeutic treatment with cyclosporine formulations which produce an average blood level concentration in the steady state range of 300 ng/ml to over 1000 ng/ml, preferably over 800 ng/ml, especially up to 900 ng/ml, preferably 400 ng/ml to 800 ng/ml in the absence of high initial blood level concentrations essentially over 1500 ng/ml, especially over 1200 ng/ml. This blood level concentration is preferably maintained for an extended period of at least 5 hours, preferably at least 7 hours.

- Pharmaceutical compounds

A compound which is a heteroaromatic[a]phenazine carboxamide derivative of formula (I) ##STR1## wherein X is a five- or six-membered heteroaromatic ring which contains one or two nitrogen atoms and which is unsubstituted or substituted by C.sub.1 -C.sub.6 alkyl, hydroxyl or C.sub.1 -C.sub.6 alkoxy; Q is C.sub.1 -C.sub.6 alkylene which is unsubstituted or substituted by C.sub.1 -C.sub.6 alkyl which is unsubstituted or substituted by a hydroxy group; and R.sub.1 and R.sub.2 which are the same or different are each C.sub.1 -C.sub.6 alkyl; or a pharmaceutically acceptable salt thereof. These compounds are inhibitors of topoisomerase I and II and can be used to treat tumours, including tumours which express MDR.

- Fractionation process

The invention refers to a process for fractionating a vegetable oil giving one or more solid fractions suitable for confectionary applications as well as a liquid fraction rich in unsaponifiable biologically active components. The liquid fractions of shea butter and rapeseed oil having a high content of phytosterols and tocoferols, respectively, are useful for cosmetical and pharmaceutical preparations.

- Use of background electrolytes to minimize flux variability during iontophoresis

A device and method are provided that minimize the changes in flux encountered during iontophoresis and reduce inter-subject variability. For drug delivery, the active agent to be delivered is administered in conjunction with at least one background ion having a hindrance factor that changes at a faster rate than the hindrance factor of the active agent when an electrical current is applied. For analyte extraction, the extraction reservoir contains at least one background ion having a hindrance factor that changes at a faster rate than the hindrance factor of the background ions of the analyte in the tissue when an electrical current is applied.

- Topical compositions and methods of application

There are topical emulsion compositions having a cosmetic drug or medicinal active, a novel compound of the present invention, and a vehicle. The novel compound is represented by a formula selected from the group consisting of L--A--H and A--L--H, wherein L is a lipophilic moiety, A is an aromatic moiety, and H is a hydrophilic moiety. Also provided are methods of emulsifying a composition; improving the photostability of a composition; and enhancing the effectiveness of a sunscreen composition.

- Therapeutical system for transdermal delivery of levonorgestrel

A stable therapeutical transdermal system for the transcutaneous delivery of levonorgestrel, alone or together with other sex steroid hormones, over a long time period is disclosed. A method of producing the transdermal system that avoids the use of solvents and avoids degradation of the steroid hormones also is disclosed.

- Method and composition for the topical treatment of diabetic neuropathy

A method and composition for the treatment of diabetic neuropathy is disclosed. The composition comprises a cold compounded mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant formulated in a pharmaceutically acceptable carrier. It has been found that this combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In view of the consensus in the art that effective combinations of various active agents have not been demonstrated to be effective for the treatment of diabetic neuropathy, the present invention provides a surprising and unexpected effect. In addition, the topical compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment, In a second aspect, a method for the topical administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is topically administered to the areas of the body that have been adversely affected by the diabetic neuropathy on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms and at least some recover of the damaged nerve tissues.

- Aminobenzophenones as inhibitors of IL-1 .beta. and TNF-.alpha.

The present invention relates to compounds of formula (I) wherein R.sub.1 and R.sub.2 independently represent one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amino (C.sub.1 -C.sub.3)alkyl, (C.sub.2 -C.sub.3)olefinic group, (C.sub.1 -C.sub.3)alkoxy, (C.sub.1 -C.sub.3)alkylthio, (C.sub.1 -C.sub.6)alkylamino, (C.sub.1 -C.sub.3)alkoxycarbonyl, cyano, carbamoyl, phenyl, or nitro; R.sub.2 further being represented by hydrogen; R.sub.3 represents hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, amino, (C.sub.1 -C.sub.3)alkyl, (C.sub.2 -C.sub.3)olefinic group, (C.sub.1 -C.sub.3)alkoxy, (C.sub.1 -C.sub.3)alkylthio, (C.sub.1 -C.sub.6)alkylamino, (C.sub.1 -C.sub.3)alkoxycarbonyl, phenyl, cyano, carboxy or carbomoyl; R.sub.4 represents hydrogen, (C.sub.1 -C.sub.3)alkyl, or allyl; X represents oxygen or sulpher; with the proviso that formula (I) does not comprise the compound 2,2,2-trifluoro-N-[2-[3-chloro-4-(2-methylbenzoyl)-phenylamino]-phenyl]ace tamide wherein R.sub.1 is a 2-methyl, R.sub.2 is 2-chloro, R.sub.3 and R.sub.4 is hydrogen, and X is oxygen; and a salt thereof with a pharmaceutically acceptable acid, a hydrate or a solvate thereof. The compounds are valuable in the human and veterinary therapy. ##STR1##

- Composition in the form of a water-in-oil emulsion having an evolutive shear rate

The present provides a composition that includes, in a physiologically acceptable medium: an aqueous phase dispersed in an oily phase with a silicone emulsifier; wherein the aqueous phase represents at least 80% by weight relative to the total weight of the composition; wherein the silicone emulsifier is an alkyldimethicone copolyol comprising an HLB of less than 8; and wherein a weight ratio of the oily phase to the silicone emulsifier is greater than or equal to 5. The present invention also provides a cosmetic, which includes the above-mentioned composition and methods of using the above-mentioned composition for treating, protecting, caring for, or removing make-up from the skin, lips or hair, cleansing the skin, lips or hair, and making up the skin or lips, treating, protecting, and caring for the scalp, and treating greasy skin. The composition can be used in particular in cosmetics and/or dermatology.

- Comixture of dextran sulfate/escin for treating skin redness/edema and/or sensitive skin

Comixtures of escin and dextran sulfate are effective for treating skin redness/edema and/or sensitive skin, particularly redness and/or edema around the eyes and most particularly bags and/or dark rings around the eyes.

- Nanoemulsions comprising at least one amphiphilic lipid, at least one oil, and at least one polyethylene glycol (PEG) ester, and uses thereof

Oil-in-water nanoemulsions comprising oil globules with an average size of less than 150 nm and comprising at least one oil, at least one amphiphilc lipid, and at least one polyethylene glycol (PEG) derivative chosen from PEG esters and PEG ethers chosen from compounds of formula (I): in which: R.sub.1 is chosen from linear and branched, saturated and unsaturated alkyl groups comprising from 8 to 30 carbon atoms and linear and branched, saturated and unsaturated acyl groups comprising from 8 to 30 carbon atoms, R.sub.2 is chosen from a hydrogen atom, linear and branched, saturated and unsaturated alkyl groups comprising from 1 to 30 carbon atoms, and linear and branched, saturated and unsaturated acyl groups comprising from 1 to 30 carbon atoms, and n is a number ranging from 80 to 350. Processes comprising such oil-in-water nanoemulsions.

- Transdermal therapeutic system (TTS) for administering sexual steroid hormones

A transdermal therapeutic system for transcutaneous administration of sexual steroid hormones over long time periods, and a solvent-free method for the production thereof, is disclosed. The steroid hormones are subjected to as little thermal exposure as possible, thereby avoiding decomposition of the steroid hormones.

- Hair-growing agent

The present invention provides a hair-growing agent comprising, as an active ingredient, a phosphatidic acid represented by formula (I): ##STR1## (wherein R.sup.1 represents straight-chain alkyl having an odd number of carbon atoms, straight-chain alkenyl having an odd number of carbon atoms, or straight-chain alkynyl having an odd number of carbon atoms).

- Hair-growing agent

The present invention provides a hair-growing agent comprising, as an active ingredient, a phosphatidic acid represented by formula (I): ##STR1## (wherein R.sup.1 represents alkyl, alkenyl, alkanoyl or alkenoyl; and when R.sup.1 represents alkyl or alkenyl, R.sup.2 represents alkyl, alkenyl, alkanoyl or alkenoyl, and when R.sup.1 represents alkanoyl or alkenoyl, R.sup.2 represents alkyl or alkenyl).

- Fluorescence detection assembly for determination of significant vegetation parameters

A basic assembly configuration for determination of relevant vegetation parameters includes a high repetitive pulsed excitation laser (1) for the stimulation of chlorophyll fluorescence, a fluorescence detector (3) including an imaging and separation optic (4, 5), a trigger and delay electronic (6) to adjust the laser and appropriate detector timing and a detector electronic (7), consisting of a signal recording and processing module. The assembly can be used for determination of relevant vegetation parameters for agricultural, horticultural and greenhouse application.

- Skin composition

Improved skin compositions which are capable of reducing oil and grease secretion from the skin comprising a combination of niacinamide and a C.sub.11 -C.sub.30 alkyl or alkenyl ester of salicylic acid formulated in a specific carrier such as a vanishing cream base are disclosed.

- Makeup or care composition comprising a hydrophilic organopolysiloxane

A transfer-resistant, mattifying composition comprising, as a thickener, particles of an at least partially crosslinked elastomeric solid organopolysiloxane in suspension in an aqueous phase. The composition is more particularly a composition for caring for or making up the lips, or a foundation composition for making up both the human face and the human body. The composition is soft and fresh on application, spreads easily, is nonsticky, and does not dry out the skin or lips. It is perfectly suited to greasy skin because of its high mattifying power.

- Cosmetic compositions, in particular for cleansing the skin

A transparent aqueous composition comprising, in a physiologically acceptable medium, (i) at least one acylisethionate, and (ii) at least one protein hydrolysate containing a hydrophobic group, in an amount which is sufficient to dissolve the acylisethionate in the composition.

- Topical composition comprising a three membered cyclic compound-based cosmetic bonding agent

The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a three membered functional cyclic bonding agent having the structure ##STR1## wherein X represents a cosmetic benefit agent that may or may not be attached to a chemical linker and Y represents O, NH, S, or Se; and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various products that include the claimed compositions.

- Effervescent bath tablet, method of preparing it, and the use thereof

The present invention relates to a new type of solid balneological preparations for cosmetic, hygienic and therapeutic use, which has both the properties of a solid bath additive and those of liquid products, and is characterized especially by the addition of lipid components, vesicle forming lipids, tensides and, in some cases, mineral salts. Active components, adjuvants such as stabilizers, adsorbing substances, lubricants as well as smoothing and breakdown promoting agents may also be contained therein.

- Aminobenzophenones as inhibitors of IL-1.beta. and TNF-.alpha.

The present invention relates to a compound of general formula (I) wherein R.sub.1, R.sub.2, and R.sub.3 represents one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amino, (C.sub.1 -C.sub.3)alkyl, (C.sub.2 -C.sub.3)olefinic group, (C.sub.1 -C.sub.3)alkoxy, (C.sub.1 -C.sub.3)akylthio, (C.sub.1 -C.sub.6)alkylamino, (C.sub.1 -C.sub.3)alkoxycarbonyl, cyano, --CONH.sub.2, phenyl, or nitro; further R.sub.2 can be hydrogen, and R.sub.3 can be carboxy and carbamoyl; R.sub.4 represents hydrogen, (C.sub.1 -C.sub.3)alkyl, or allyl; X represents oxygen or sulphur; Q represents --(CO)--, --(CS)--, or a bond; Y represents (C.sub.5 -C.sub.15)alkyl; (C.sub.2 -C.sub.15)olefinic group; (C.sub.3 -C.sub.10)monocyclic hydrocarbon group; or phenyl; any of which may be optionally substituted by one or more, same or different substituents selected from the group consisting of the formula R.sub.5 defined below; (C.sub.1 -C.sub.4)alkyl substituted by one or more substituents selected for the group R.sub.5 ; or a group of the formula --(Z--O).sub.n --Z, wherein Z is a (C.sub.1 -C.sub.3)alkyl, n is an integer >1; and no continuous linear sequence of atoms in the group Y exceeds 15; R.sub.5 represents halogen, hydroxy, mercapto, trifluoromethyl, amino, (C.sub.1 -C.sub.3)alkoxy, (C.sub.1 -C.sub.3)alkylthio, (C.sub.1 -C.sub.6)alkylamino, (C.sub.1 -C.sub.3)alkoxycarbonyl, cyano, azido, nitro, --COOH, --CONH.sub.2, --CONHR', or COONR'R' wherein R' represents (C.sub.1 -C.sub.3)alkyl; or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof. The compounds are valuable in the human and veterinary therapy. ##STR1##

- Combination of acid protease enzymes and acidic buffers and uses thereof

Novel compositions comprising one or more of an acid protease and an acidic buffer, the acidic buffer comprising an acid and a pharmaceutically or cosmetically 5 acceptable carrier, vehicle or excipient, useful for treating or preventing abnormal biological conditions, diseases or disorders, and/or for improving the texture or appearance of the skin, and/or for enhancing epidermal exfoliation and/or for enhancing epidermal cell renewal and to methods for the use of the compositions. The acid protease comprises one or more proteolytic enzymes that exhibit proteolytic activity at pH values below that of the surface of the skin, i.e., approximately pH 5.5. The acidic buffer comprises inorganic and/or organic acids or mixtures thereof with a pharmaceutically or cosmetically acceptable carrier, vehicle or excipient. The buffer is capable of reducing the pH of the surface of the skin to less than pH 5.5 and is susceptible to neutralization by normal epidermal processes.

- Multiphase stick preparation

An improved stick preparation is provided which is made up of at least two separate phases and at least one phase contains spherical polymer particles which can contain a pigment. The particles provide smoothness to the preparation and can be used to provide an interesting visual appearance to the stick.

- Low-molecular heparin modification and remedy for skin ulcer

The invention is direct to modified heparins, especially low-molecular weight modified heparins that are adapted for used in preparing an agent for treating a skin ulcer. The low-molecular weight modified heparins have been substantially deprived of the anticoagulant activity, yet they retain the ability to bind to cell growth factors, cytokines and cell adhesion molecules.

- Sustained-release nalmefene preparations and method

A nalmefene transdermal delivery system useful for the treatment of human patients suffering from opioid addiction.

- Composition containing a precursor capable of being hydrolysed by glucocerebrosidase

The invention concerns a composition capable of being hydrolyzed by a cutaneous enzyme, glucocerebrosidase. The active precursor is advantageously a gluco-conjugate derived from phenol whereof the two .alpha. carbons are free. The invention also concerns the use of such compositions against light-induced skin ageing or for making a medicine for treating certain skin diseases. The invention further concerns novel glucosylated compounds.

- Anhydrous cosmetic makeup composition containing a fatty phase

An anhydrous cosmetic makeup composition contains in addition to a fatty phase formed from oils, fatty bodies and surfactants, and optionally waxes, a vesicular lipidic phase that contains at least one ionic or nonionic amphiphilic lipid and optionally additives. The anhydrous composition also preferably contains at least one cosmetically and/or dermopharmaceutically active material. In the presence of an aqueous phase these compositions release vesicles of the vesicular lipidic phase and potentialize the activity of the cosmetically and/or dermopharmaceutically active material of the composition.

- Cosmetic or dermopharmaceutical composition in the form of beads and methods for preparing same

The invention concerns an anhydrous solid composition comprising at least a hydrophobic wax, an oil and talcum, having preferably the form of beads with size ranging from 1 to 10000 microns. The beads can contain a cosmetic or pharmaceutical active principle, pigments or an agri-food constituent. The invention also concerns the method for preparing said beads.